                               SEQUENCE LISTING

<110> REGENXBIO INC.
 
<120> FULLY-HUMAN POST-TRANSLATIONALLY MODIFIED ANTIBODY THERAPEUTICS

<130> 38013.0001P1

<140>
<141>

<150> 62/967,472
<151> 2020-01-29

<150> 62/838,165
<151> 2019-04-24

<160> 454   

<170> PatentIn version 3.5

<210> 1
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (217)..(237)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (220)..(220)
<223> /replace="Leu"

<220>
<221> SITE
<222> (221)..(237)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (227)..(237)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(237)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235         


<210> 2
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser 
            20                  25                  30          


Asp Gly Asn Ala Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 3
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace="Val"

<220>
<221> SITE
<222> (220)..(240)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Leu"

<220>
<221> SITE
<222> (224)..(240)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (230)..(240)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(240)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Ser Asn Leu Ala Tyr Ser Ile Asp Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
225                 230                 235                 240 


<210> 4
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Val Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Thr 
                85                  90                  95      


Arg His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 5
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (234)..(254)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (237)..(237)
<223> /replace="Leu"

<220>
<221> SITE
<222> (238)..(254)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (244)..(254)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(254)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ile Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Gly Ile Ala Leu Ala Gly Pro Ala Ser Arg Gly 
            100                 105                 110         


Tyr Gln Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 


<210> 6
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Arg Leu Gly Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 7
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (218)..(237)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Ser"

<220>
<221> SITE
<222> (227)..(237)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(237)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 7
Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Glu Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Ser Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Asn Trp Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235         


<210> 8
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Arg Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Phe Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His His Ser Trp 
                85                  90                  95      


Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 9
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (61)..(61)
<223> /replace="Thr"

<220>
<221> SITE
<222> (221)..(240)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Ser"

<220>
<221> SITE
<222> (230)..(240)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(240)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 9
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ala Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


<210> 10
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 11
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (229)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (232)..(232)
<223> /replace="Leu"

<220>
<221> SITE
<222> (233)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (239)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(249)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 11
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Ser Asn Glu Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Gly Ala Ser Val Thr Thr Ser Asn Ala Glu Asn Phe His 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Ala Gly Ala Pro Ser Val Phe Leu 
                245                 


<210> 12
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Arg Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Thr Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Asn Gly His His 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Cys Ser 
    210             


<210> 13
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (226)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (231)..(231)
<223> /replace="Ser"

<220>
<221> SITE
<222> (235)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(245)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 13
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Pro Thr Thr Gly Gly Ala Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Tyr Gly Arg His Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Thr Val 
                165                 170                 175     


Ser Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210> 14
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                165                 170                 175     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            180                 185                 190         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        195                 200                 205             


Glu Cys 
    210 


<210> 15
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (221)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Leu"

<220>
<221> SITE
<222> (225)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (231)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(241)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210> 16
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 17
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (229)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (232)..(232)
<223> /replace="Leu"

<220>
<221> SITE
<222> (233)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (239)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(249)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Lys Arg Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Asn Arg Asp Thr Ser Ala Ser Thr Ile Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Asp His Ala Gly Ser Gly Ser Tyr Leu Ser Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 


<210> 18
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 19
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (227)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (230)..(230)
<223> /replace="Leu"

<220>
<221> SITE
<222> (231)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (237)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(247)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 19
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser His Leu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Ala Asn His Gly Lys Tyr Tyr Tyr Gly Met Asp Lys Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210> 20
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ala Pro Leu Pro Lys 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ala Asp Lys His Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Val Trp Asp His Gly Val Trp Tyr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        115                 120                 125             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                165                 170                 175     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            180                 185                 190         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        195                 200                 205             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 220     


<210> 21
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (231)..(251)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (234)..(234)
<223> /replace="Leu"

<220>
<221> SITE
<222> (235)..(251)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (241)..(251)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(251)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Val Trp Val 
        35                  40                  45              


Ser Arg Thr Asn Thr Asp Gly Arg Asn Thr Ala Tyr Ala Asp Tyr Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Arg Arg Asn Val Ala Asp Gln Ile Thr His Asn Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                245                 250     


<210> 22
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ala Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Arg Gly Lys Ala Pro Lys Leu Leu Ile Phe 
        35                  40                  45              


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 23
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (228)..(248)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (231)..(231)
<223> /replace="Leu"

<220>
<221> SITE
<222> (232)..(248)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (238)..(248)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(248)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 23
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Arg Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Thr Gly Thr Thr Phe Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Pro Asp Arg Val Ser Val Thr Arg Asp Thr Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  


Met Glu Leu His Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ile Ser Glu His Gly Ser Gly Ser Tyr Ser Pro Tyr Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu 
                245             


<210> 24
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Met Ala Ala Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Gly 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Arg Asp Val Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Ser Ser Gly Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210> 25
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (216)..(236)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (219)..(219)
<223> /replace="Leu"

<220>
<221> SITE
<222> (220)..(236)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (226)..(236)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(236)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Thr Leu 
225                 230                 235     


<210> 26
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 27
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (228)..(238)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (234)..(238)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Glu Ser Asp Ala Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Leu Ala Tyr Phe Asp Tyr Gly Leu Ala Ile Gln Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235             


<210> 28
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Lys Arg Val Thr Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Leu Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Tyr Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 29
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (222)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Ser"

<220>
<221> SITE
<222> (231)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(241)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gly Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Glu Gly Thr Gly Lys Thr Val Tyr Ile Gln Lys Phe 
    50                  55                  60                  


Ala Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Asp Tyr Val Ser Gly Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210> 30
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Gly Tyr His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 31
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (227)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (230)..(230)
<223> /replace="Leu"

<220>
<221> SITE
<222> (231)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (237)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(247)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Asn 
            20                  25                  30          


Asp Val Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Met Thr Thr Asp Val Val Thr Glu Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Ser Arg Phe Thr Val Ser Arg Asp Ser Ala Lys Asn Ser Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Ser Val Gly Ser Pro Leu Met Ser Phe Asp Leu Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210> 32
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Tyr Asn Asn 
            20                  25                  30          


Asn Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gly Gly Tyr Lys Ser Tyr 
                85                  90                  95      


Ser Asn Asp Gly Asn Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 33
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (222)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Leu"

<220>
<221> SITE
<222> (232)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(242)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 33
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Tyr Arg Ser Glu Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Ser Glu Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210> 34
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp His Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Thr Phe Glu Gly Asp Tyr 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210> 35
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (232)..(252)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Leu"

<220>
<221> SITE
<222> (236)..(252)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (242)..(252)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(252)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 35
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Thr Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Val Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Val Pro Gly Gly Asp Pro Gly Leu Glu His 
            100                 105                 110         


Ala Phe Ala Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250         


<210> 36
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Gly Thr Tyr Tyr Val 
            20                  25                  30          


Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Phe Ala Ser Trp Ser Asp Ser 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210> 37
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (224)..(234)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (230)..(234)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 37
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Glu Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Val Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 


<210> 38
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 39
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (221)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Leu"

<220>
<221> SITE
<222> (225)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (231)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(241)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 39
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Gly Pro Phe Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210> 40
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ser Ile Pro Asn Tyr Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser Ser Leu Asn Ala 
                85                  90                  95      


Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 41
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (223)..(243)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Leu"

<220>
<221> SITE
<222> (227)..(243)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (233)..(243)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(243)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 41
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Ser Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Trp Arg Arg Phe Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu 
            


<210> 42
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 43
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (226)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Leu"

<220>
<221> SITE
<222> (230)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (236)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(246)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 43
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Tyr His Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile His Pro Asn Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Glu Ser Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Glu Arg Asp Ser Thr Glu Val Leu Pro Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu 
                245     


<210> 44
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Asn Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 45
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (226)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Leu"

<220>
<221> SITE
<222> (230)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (236)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(246)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu 
                245     


<210> 46
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 47
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (225)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> SITE
<222> (229)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (235)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(245)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 47
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210> 48
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 49
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (234)..(254)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (237)..(237)
<223> /replace="Leu"

<220>
<221> SITE
<222> (238)..(254)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (244)..(254)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(254)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 49
Ser Lys Leu Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
1               5                   10                  15      


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe 
            20                  25                  30          


Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 


<210> 50
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Ala Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
1               5                   10                  15      


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
            20                  25                  30          


Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
                85                  90                  95      


Trp Pro Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 51
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (225)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> SITE
<222> (229)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (235)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(245)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 51
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Tyr Ser Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Ser Gly Pro Tyr Tyr Tyr Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210> 52
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Ser Val Gly Asp Ser 
            20                  25                  30          


Ile Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Leu Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Tyr Ala Gly Thr 
                85                  90                  95      


Asp Thr Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210> 53
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (225)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> SITE
<222> (229)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (235)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(245)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 53
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ile Ser Arg 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Gly Ile Tyr His Ser Gly Asn Thr Tyr Asp Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Val Pro Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210> 54
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ala Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Arg Gly Lys Ala Pro Lys Leu Leu Ile Phe 
        35                  40                  45              


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 55
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (222)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Leu"

<220>
<221> SITE
<222> (226)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (232)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(242)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Tyr Gly Gln Tyr Phe Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210> 56
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 57
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (221)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Leu"

<220>
<221> SITE
<222> (225)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (231)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(241)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 57
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Gly Pro Phe Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210> 58
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 58
Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ser Ile Pro Asn Tyr Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser Ser Leu Asn Ala 
                85                  90                  95      


Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 59
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (225)..(235)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (231)..(235)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 59
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly His Ser Ile Ser His Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Glu Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Phe Ile Ser Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Glu Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235 


<210> 60
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Gln Ala Ser Thr Asp Ile Ser Ser His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Gly Ser His Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gly Gln Gly Asn Arg Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Glu Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 61
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (221)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Leu"

<220>
<221> SITE
<222> (225)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (231)..(241)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(241)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210> 62
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 63
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (226)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Leu"

<220>
<221> SITE
<222> (230)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (236)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(246)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Phe Ile Thr Thr Val Arg Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu 
                245     


<210> 64
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Thr Phe 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Asp Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile His Glu Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 65
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (222)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Leu"

<220>
<221> SITE
<222> (226)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (232)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(242)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Phe Ile Thr Asn Asn 
            20                  25                  30          


Tyr Trp Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Phe Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Gly Ser Ser Gly Tyr Phe Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210> 66
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asp Leu 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 67
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (229)..(239)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (235)..(239)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 67
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
    210                 215                 220                 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 


<210> 68
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 68
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 69
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (227)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (230)..(230)
<223> /replace="Leu"

<220>
<221> SITE
<222> (231)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (237)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(247)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 69
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Ser Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Arg Arg Ile Gly Val Pro Arg Arg Asp Glu Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210> 70
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 71
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (649)..(711)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (658)..(660)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (661)..(711)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (679)..(711)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(711)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 71
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc aggtacagca tgagctgggt gaggcaggcc      120

cccggcaagg gcctggagct ggtggcccag atcaacagcg tgggcaacag cacctactac      180

cccgacaccg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc cagcggcgac      300

tactggggcc agggcaccct ggtgaccgtg agcagcgcca gcaccaaggg ccccagcgtg      360

ttccccctgg cccccagcag caagagcacc agcggcggca ccgccgccct gggctgcctg      420

gtgaaggact acttccccga gcccgtgacc gtgagctgga acagcggcgc cctgaccagc      480

ggcgtgcaca ccttccccgc cgtgctgcag agcagcggcc tgtacagcct gagcagcgtg      540

gtgaccgtgc ccagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaggtgga caagaaggtg gagcccaaga gctgcgacaa gacccacacc      660

tgccccccct gccccgcccc cgagctgctg ggcggcccca gcgtgttcct g               711


<210> 72
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 72
gacgtggtga tgacccagag ccccctgagc ctgcccgtga ccctgggcca gcccgccagc       60

atcagctgca ggagcagcca gagcctgatc tacagcgacg gcaacgccta cctgcactgg      120

ttcctgcaga agcccggcca gagccccagg ctgctgatct acaaggtgag caacaggttc      180

agcggcgtgc ccgacaggtt cagcggcagc ggcagcggca ccgacttcac cctgaagatc      240

agcagggtgg aggccgagga cgtgggcgtg tactactgca gccagagcac ccacgtgccc      300

tggaccttcg gccagggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagggg cgagtgc         657


<210> 73
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (70)..(72)
<223> /replace="gtg"

<220>
<221> misc_feature
<222> (658)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (667)..(669)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (670)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (688)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(720)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 73
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc gacaacggca tggcctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcttc atcagcaacc tggcctacag catcgactac      180

gccgacaccg tgaccggcag gttcaccatc agcagggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgt gagcggcacc      300

tggttcgcct actggggcca gggcaccctg gtgaccgtga gcagcgccag caccaagggc      360

cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac cgccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgagctggaa cagcggcgcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgcgacaag      660

acccacacct gccccccctg ccccgccccc gagctggccg gcgcccccag cgtgttcctg      720


<210> 74
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 74
gacatcgtga tgacccagag ccccctgagc ctgcccgtga cccccggcga gcccgccagc       60

atcagctgca gggtgagcca gagcctgctg cacagcaacg gctacaccta cctgcactgg      120

tacctgcaga agcccggcca gagcccccag ctgctgatct acaaggtgag caacaggttc      180

agcggcgtgc ccgacaggtt cagcggcagc ggcagcggca ccgacttcac cctgaagatc      240

agcagggtgg aggccgagga cgtgggcgtg tactactgca gccagaccag gcacgtgccc      300

tacaccttcg gcggcggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagggg cgagtgc         657


<210> 75
<211> 762
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (700)..(762)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (709)..(711)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (712)..(762)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (730)..(762)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(762)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 75
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aagtactaca tgagctgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcatc atcaacccca tcggcggcag caccagctac      180

gcccagaagt tccagggcag ggtgaccatg accagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cagggacccc      300

agcggcatcg ccctggccgg ccccgccagc aggggctacc agggcatgga cgtgtggggc      360

cagggcacca ccgtgaccgt gagcagcgcc agcaccaagg gccccagcgt gttccccctg      420

gcccccagca gcaagagcac cagcggcggc accgccgccc tgggctgcct ggtgaaggac      480

tacttccccg agcccgtgac cgtgagctgg aacagcggcg ccctgaccag cggcgtgcac      540

accttccccg ccgtgctgca gagcagcggc ctgtacagcc tgagcagcgt ggtgaccgtg      600

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      660

accaaggtgg acaagagggt ggagcccaag agctgcgaca agacccacac ctgccccccc      720

tgccccgccc ccgagctgct gggcggcccc agcgtgttcc tg                         762


<210> 76
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 76
gagatcgtga tgacccagag ccccgccacc ctgagcgtga gccccggcga gagggccacc       60

ctgagctgca gggccagcca gagcgtgagc agcaacctgg cctggtacca gcagaagccc      120

ggccaggccc ccaggctgct gatctacggc gccagcacca gggccaccgg catccccgcc      180

aggttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag cctgcagagc      240

gaggacttcg ccgtgtacta ctgccagcag gccaggctgg gcccctggac cttcggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 77
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (652)..(711)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (667)..(668)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (679)..(711)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(711)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 77
gaggtgaagg tggtggagag cggcggcggc ctggtgcagc ccggcggcag catgaagctg       60

agctgcgtgg tgagcggctt caccttcagc aactactggg tgaactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggcccag atcaggctga agagcgacaa ctacgccacc      180

cactacgagg agagcgtgaa gggcaggttc accatcagca gggacgacag caagagcagc      240

gtgtacctgc agatgaacaa cctgagggcc gaggacagcg gcatctacta ctgcaccaac      300

tgggaggact actggggcca gggcaccacc gtgaccgtga gcagcgccag caccaagggc      360

cccagcgtgt tccccctggc cccctgcagc aggagcacca gcgagagcac cgccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgagctggaa cagcggcgcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

agcagcgtgg tgaccgtgcc cagcagcagc ctgggcacca agacctacac ctgcaacgtg      600

gaccacaagc ccagcaacac caaggtggac aagagggtgg agagcaagta cggccccccc      660

tgccccccct gccccgcccc cgagttcctg ggcggcccca gcgtgttcct g               711


<210> 78
<211> 654
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 78
gacatcgtgc tgacccagag ccccgacagc ctggccgtga gcctgggcga gagggccacc       60

atcagctgca gggccagcca gagcgtgagc accagcaggt acagctacat ccactggtac      120

cagcagaagc ccggccagtt ccccaagctg ctgatcaagt acgccagcaa cctggagagc      180

ggcgtgccca gcaggttcag cggcagcggc agcggcaccg acttcaccct gaacatccac      240

cccctggagc ccgaggactt cgccacctac tactgccacc acagctggga gatccccctg      300

accttcggcc agggcaccaa gctggagatc aagaggaccg tggccgcccc cagcgtgttc      360

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg      420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaacagcc aggagagcgt gaccgagcag gacagcaagg acagcaccta cagcctgagc      540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      600

acccaccagg gcctgagcag ccccgtgacc aagagcttca acaggggcga gtgc            654


<210> 79
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (181)..(183)
<223> /replace="acc"

<220>
<221> misc_feature
<222> (661)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (676)..(677)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (688)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(720)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 79
gaggtgcagc tgcaggagag cggccccggc ctggtgaagc ccagcgagac cctgagcctg       60

acctgcaccg tgagcggctt cagcctgacc agcaacgaca tcgcctggat caggcagccc      120

cccggcaagg gcctggagtg gatgggcacc atctggaccg acggcagcac caactacaac      180

gccgccgtgc agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgaccgc cgccgacacc gccgtgtact actgcgccag gcacaggctg      300

tactacggcg ccttcgacta ctggggccag ggcaccatgg tgaccgtgag cagcgccagc      360

accaagggcc ccagcgtgtt ccccctggcc ccctgcagca ggagcaccag cgagagcacc      420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      480

agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      540

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccaa gacctacacc      600

tgcaacgtgg accacaagcc cagcaacacc aaggtggaca agagggtgga gagcaagtac      660

ggccccccct gccccccctg ccccgccccc gagttcctgg gcggccccag cgtgttcctg      720


<210> 80
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 80
gacatcgtga tgacccagac ccccctgagc ctgagcgtga cccccggcca gcccgccagc       60

atcagctgca ggagcagcca gagcctggag tacagcgacg gctacaccta cctggagtgg      120

tacctgcaga agcccggcca gagcccccag ctgctgatct acgaggtgag caacaggttc      180

agcggcgtgc ccgacaggtt cagcggcagc ggcagcggca ccgacttcac cctgaagatc      240

agcagggtgg aggccgagga cgtgggcgtg tactactgct tccaggccac ccacaacccc      300

tacaccttcg gccagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagggg cgagtgc         657


<210> 81
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (685)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (694)..(696)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (697)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (715)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(747)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 81
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgagggtg       60

agctgcgccg ccagcggctt caccttcagc agctacgaca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccgtg atctggttcg acggcagcaa cgagttctac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgttc      240

cagatgaaca gcctgagggc cgaggacacc gccgtgtact actgcgccag ggacctgggc      300

gccagcgtga ccaccagcaa cgccgagaac ttccaccact ggggccaggg caccctggtg      360

accgtgagca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtga gctggaacag cggcgccctg accagcggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

aaggtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc cgcccccgag      720

ctggccggcg cccccagcgt gttcctg                                          747


<210> 82
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 82
agctacgagc tgacccagcc ccccagcgtg agcgtgagcc ccggccagac cgccaggatc       60

acctgcagcg gcgacgccct gcccaagagg tacgtgtact ggtaccagca gaagagcggc      120

caggcccccg tgctggtgat ctacgaggac agcaagaggc ccagcggcat ccccgagacc      180

ttcagcggca gcagcagcgg caccatggcc accctgacca tcagcggcgc ccaggtggag      240

gacgaggccg actactactg ctacagcacc gacagcaacg gccaccactg ggtgttcggc      300

ggcggcacca agctgaccgt gctgggccag cccaaggccg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctaccccg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggagctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaagac cgtggccccc acctgcagc                             639


<210> 83
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (676)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (691)..(692)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (703)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(735)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 83
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcta cagcttcagc gactactaca tgcactgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggccag atcaacccca ccaccggcgg cgccagctac      180

aaccagaagt tcaagggcaa ggccaccatc accgtggaca agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggtactac      300

tacggcaggc acttcgacgt gtggggccag ggcaccaccg tgaccgtgag cagcgccagc      360

accaagggcc ccagcgtgtt ccccctggcc ccctgcagca ggagcaccag cgagagcacc      420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      480

agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg tgaccgtgag cagcgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

accaagacct acacctgcaa cgtggaccac aagcccagca acaccaaggt ggacaagagg      660

gtggagagca agtacggccc cccctgcccc ccctgccccg cccccgagtt cctgggcggc      720

cccagcgtgt tcctg                                                       735


<210> 84
<211> 630
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 84
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gagggccacc       60

atcaactgca aggccagcca gagcgtggac tacgacggcg acagctacat gaactggtac      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacg ccgccagcaa cctggagagc      180

ggcgtgcccg acaggttcag cggcagcggc agcggcaccg acttcaccct gaccatcagc      240

agcctgcagg ccgaggacgt ggccgtgtac tactgccagc agagcaacga ggacccctac      300

accttcggcc agggcaccaa gctggagatc aagttcatct tcccccccag cgacgagcag      360

ctgaagagcg gcaccgccag cgtggtgtgc ctgctgaaca acttctaccc cagggaggcc      420

aaggtgcagt ggaaggtgga caacgccctg cagagcggca acagccagga gagcgtgacc      480

gagcaggaca gcaaggacag cacctacagc ctgagcagca ccctgaccct gagcaaggcc      540

gactacgaga agcacaaggt gtacgcctgc gaggtgaccc accagggcct gagcagcccc      600

gtgaccaaga gcttcaacag gggcgagtgc                                       630


<210> 85
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (661)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (670)..(672)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (673)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (691)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(723)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 85
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc aactacggca tgagctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccagc atcagcagcg gcggcggcag cacctactac      180

cccgacaacg tgaagggcag gttcaccatc agcagggacg acgccaagaa cagcctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caggggcggc      300

gccggcatcg actactgggg ccagggcacc ctggtgaccg tgagcagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg caccgccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgagctg gaacagcggc      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaggg tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgccccgcc cccgagctgc tgggcggccc cagcgtgttc      720

ctg                                                                    723


<210> 86
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 86
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcatcca gaccctgctg tacagcagca accagaagaa ctacctggcc      120

tggttccagc agaagcccgg caaggccccc aagctgctga tctactgggc cagcatcagg      180

aagagcggcg tgcccagcag gttcagcggc agcggcagcg gcaccgactt caccctgacc      240

atcagcagcc tgcagcccga ggacctggcc acctactact gccagcagta ctacagctac      300

cccctgacct tcggcggcgg caccaagctg gagatcaaga ggaccgtggc cgcccccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc cagggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggacag cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      600

gaggtgaccc accagggcct gagcagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210> 87
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (685)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (694)..(696)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (697)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (715)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(747)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 87
gaggtgcagc tggtggagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacgcca tgcactgggt gaggcaggcc      120

cccggccaga ggctggagtg gatgggctgg atcaacgccg gcaacggcaa gaggaagtac      180

agccagaagt tccaggacag ggtgaccatc aacagggaca ccagcgccag caccatctac      240

atggagctga gcagcctggg cagcgaggac accgccgtgt actactgcgc cagggaggag      300

gaccacgccg gcagcggcag ctacctgagc atggacgtgt ggggccaggg caccctggtg      360

accgtgagca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtga gctggaacag cggcgccctg accagcggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agggtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc cgcccccgag      720

ctgctgggcg gccccagcgt gttcctg                                          747


<210> 88
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 88
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcatcca gaccctgctg tacagcagca accagaagaa ctacctggcc      120

tggttccagc agaagcccgg caaggccccc aagctgctga tctactgggc cagcatcagg      180

aagagcggcg tgcccagcag gttcagcggc agcggcagcg gcaccgactt caccctgacc      240

atcagcagcc tgcagcccga ggacctggcc acctactact gccagcagta ctacagctac      300

cccctgacct tcggcggcgg caccaagctg gagatcaaga ggaccgtggc cgcccccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc cagggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggacag cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      600

gaggtgaccc accagggcct gagcagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210> 89
<211> 741
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (679)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (688)..(690)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (691)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (709)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(741)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 89
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcagc atcagccacc tgggcggcag cacctactac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc cggcggcgcc      300

aaccacggca agtactacta cggcatggac aagtggggcc agggcaccac cgtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagggtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc cgagttcgag      720

ggcggcccca gcgtgttcct g                                                741


<210> 90
<211> 663
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 90
caggccgtgc tgacccagcc cgccagcctg agcgccagcc ccggcgccag cgccagcctg       60

acctgcaccc tgaggagcgg cgcccccctg cccaagtaca ggatctactg gtaccagcag      120

aagcccggca gcccccccca gtacctgctg aggtacaaga gcgacgccga caagcaccag      180

ggcagcggcg tgcccagcag gttcagcggc agcaaggacg ccagcgccaa cgccggcatc      240

ctgctgatca gcggcctgca gagcgaggac gaggccgact actactgcat ggtgtgggac      300

cacggcgtgt ggtacttcgg cggcggcacc aagctgaccg tgctgggcca gcccaaggcc      360

gcccccagcg tgaccctgtt cccccccagc agcgaggagc tgcaggccaa caaggccacc      420

ctggtgtgcc tgatcagcga cttctacccc ggcgccgtga ccgtggcctg gaaggccgac      480

agcagccccg tgaaggccgg cgtggagacc accaccccca gcaagcagag caacaacaag      540

tacgccgcca gcagctacct gagcctgacc cccgagcagt ggaagagcca caggagctac      600

agctgccagg tgacccacga gggcagcacc gtggagaaga ccgtggcccc caccgagtgc      660

agc                                                                    663


<210> 91
<211> 753
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (691)..(753)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (700)..(702)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (703)..(753)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (721)..(753)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(753)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 91
gaggtgcagc tggtggagag cggcggcgac ctggtgaggc ccggcggcag cctgaggctg       60

agctgcgtgg ccagcggctt caccttcagc aactactgga tgcactgggt gaggcaggcc      120

cccggccaga ggcccgtgtg ggtgagcagg accaacaccg acggcaggaa caccgcctac      180

gccgactacg ccaagggcag gttcaccatc agcagggaca acgccaagag caccctgtac      240

ctgcagctga acagcctgag ggccgaggac accgccgtgt acttctgcgc caggctgagg      300

aggaacgtgg ccgaccagat cacccacaac tactacatgg acgtgtgggg caagggcacc      360

ctggtgaccg tgagcagcgc cagcaccaag ggccccagcg tgttccccct ggcccccagc      420

agcaagagca ccagcggcgg caccgccgcc ctgggctgcc tggtgaagga ctacttcccc      480

gagcccgtga ccgtgagctg gaacagcggc gccctgacca gcggcgtgca caccttcccc      540

gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgaccgt gcccagcagc      600

agcctgggca cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggagcccaa gagctgcgac aagacccaca cctgcccccc ctgccccgcc      720

cccgaggccg ccggcggccc cagcgtgttc ctg                                   753


<210> 92
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 92
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

gcctgcaggg ccagccagag cgtgggcacc tacctgaact ggtaccagca gaagaggggc      120

aaggccccca agctgctgat cttcgccgcc agcagcctgc agagcggcgt gcccagcagg      180

ttcagcggca gcggcagcgg caccgacttc accctgacca tcagcagcct gcagcccgag      240

gacttcgcca cctactactg ccagcagagc tacagcagcc cccccacctt cggccagggc      300

accaaggtgg agatcaagag gaccgtggcc gcccccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

agggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg      600

agcagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210> 93
<211> 744
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (682)..(744)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (691)..(693)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (694)..(744)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (712)..(744)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(744)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 93
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaccctg       60

agctgcaagg ccagcggcta caccttcacc gcctactaca tccactgggt gaggcaggcc      120

agggagcagg gcctggagtg gatgggcgtg atcaacccca gcaccggcac caccttctac      180

gcccagaact tccccgacag ggtgagcgtg accagggaca ccagcaccag caccgtgttc      240

atggagctgc acaacctgaa gagcgaggac accgccgtgt actactgcgc cagggccatc      300

agcgagcacg gcagcggcag ctacagcccc tactactggg gccagggcac cctggtgacc      360

gtgagcagcg ccagcaccaa gggccccagc gtgttccccc tggcccccag cagcaagagc      420

accagcggcg gcaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggagccca agagctgcga caagacccac acctgccccc cctgccccgc ccccgaggcc      720

gccggcggcc ccagcgtgtt cctg                                             744


<210> 94
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 94
agctacgagc tgacccagcc ccccagcgtg agcgtgagcc tgggccagat ggccgccatc       60

acctgcagcg gcgaggccct gcccaagaag tacggctact ggtaccagca gaagcccggc      120

caggtgcccg tgctgctgat ctacagggac gtggagaggc ccagcggcgt gcccgacagg      180

ttcagcggca gcagcagcgg caccatggtg accctgacca tcagcggcgt gcaggccgag      240

gacgaggccg actactactg cctgagcgcc gacagcagcg gcacctgggt gttcggcggc      300

ggcaccaagc tgaccgtgct g                                                321


<210> 95
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (646)..(708)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (655)..(657)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (658)..(708)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (676)..(708)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(708)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 95
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg tgagcggcat cgacctgagc ggctactaca tgaactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcgtg atcggcatca acggcgccac ctactacgcc      180

agctgggcca agggcaggtt caccatcagc agggacaaca gcaagaccac cgtgtacctg      240

cagatgaaca gcctgagggc cgaggacacc gccgtgtact tctgcgccag gggcgacatc      300

tggggccagg gcaccctggt gaccgtgagc agcgccagca ccaagggccc cagcgtgttc      360

cccctggccc ccagcagcaa gagcaccagc ggcggcaccg ccgccctggg ctgcctggtg      420

aaggactact tccccgagcc cgtgaccgtg agctggaaca gcggcgccct gaccagcggc      480

gtgcacacct tccccgccgt gctgcagagc agcggcctgt acagcctgag cagcgtggtg      540

accgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacgc cagggtggag cccaagagct gcgacaagac ccacacctgc      660

cccccctgcc ccgcccccga gctgctgggc ggccccagcg tgaccctg                   708


<210> 96
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 96
caggtgctga cccagagccc cagcagcctg agcgccagcg tgggcgacag ggtgaccatc       60

aactgccagg ccagccagag cgtgtaccac aacacctacc tggcctggta ccagcagaag      120

cccggcaagg tgcccaagca gctgatctac gacgccagca ccctggccag cggcgtgccc      180

agcaggttca gcggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctgcag      240

cccgaggacg tggccaccta ctactgcctg ggcagctacg actgcaccaa cggcgactgc      300

ttcgtgttcg gcggcggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagggg cgagtgc         657


<210> 97
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (682)..(714)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (700)..(714)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 97
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc aactactgga tcagctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccgag atcaggagcg agagcgacgc cagcgccacc      180

cactacgccg aggccgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcctggcc      300

tacttcgact acggcctggc catccagaac tactggggcc agggcaccct ggtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg ccccctgcag caggagcacc      420

agcgagagca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcaa cttcggcacc      600

cagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga caagaccgtg      660

gagaggaagt gctgcgtgga gtgccccccc tgccccgccc cccccgtggc cggc            714


<210> 98
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 98
gagatcgtgc tgacccagag ccccgccacc ctgagcctga gccccggcga gagggccacc       60

ctgagctgca aggccagcaa gagggtgacc acctacgtga gctggtacca gcagaagccc      120

ggccaggccc ccaggctgct gatctacggc gccagcaaca ggtacctggg catccccgcc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtgtacta ctgcagccag agctacaact acccctacac cttcggccag      300

ggcaccaagc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 99
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (664)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (679)..(680)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (691)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(723)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 99
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcggc aactactgga tgcagtgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcgcc atctacgagg gcaccggcaa gaccgtgtac      180

atccagaagt tcgccgacag ggtgaccatc accgccgaca agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggctgagc      300

gactacgtga gcggcttcgg ctactggggc cagggcacca ccgtgaccgt gagcagcgcc      360

agcaccaagg gccccagcgt gttccccctg gccccctgca gcaggagcac cagcgagagc      420

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg      480

aacagcggcg ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac caagacctac      600

acctgcaacg tggaccacaa gcccagcaac accaaggtgg acaagagggt ggagagcaag      660

tacggccccc cctgcccccc ctgccccgcc cccgaggccg ccggcggccc cagcgtgttc      720

ctg                                                                    723


<210> 100
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 100
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcaa ggacatcagc aagtacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcggct accacagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcgacgccc tgccccccac cttcggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 101
<211> 741
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (679)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (688)..(690)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (691)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (709)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(741)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 101
gaggtgcagc tggtggagag cggcggcggc ctggtgaagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt cagcttcagc aacaacgacg tgatgtgctg ggtgaggcag      120

gcccccggca agggcctgga gtggatcggc tgcatcatga ccaccgacgt ggtgaccgag      180

tacgccaact gggccaagag caggttcacc gtgagcaggg acagcgccaa gaacagcgtg      240

tacctgcaga tgaacagcct gagggccgag gacaccgccg tgtacttctg cgccagggac      300

agcgtgggca gccccctgat gagcttcgac ctgtggggcc ccggcaccct ggtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc cgagctgctg      720

ggcggcccca gcgtgttcct g                                                741


<210> 102
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 102
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcaactgcc aggccagcca gagcatctac aacaacaacg agctgagctg gtaccagcag      120

aagcccggca agccccccaa gctgctgatc tacagggcca gcaccctggc cagcggcgtg      180

cccagcaggt tcagcggcag cggcagcggc accgacttca ccctgaccat cagcagcctg      240

cagcccgagg acgtggccac ctactactgc ggcggctaca agagctacag caacgacggc      300

aacggcttcg gcggcggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagggg cgagtgc         657


<210> 103
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (664)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (673)..(675)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (676)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (694)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(726)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 103
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgagag cctgaagatc       60

agctgcaagg gcagcggcta cagcttcacc agctactgga tcggctgggt gaggcagatg      120

cccggcaagg gcctggagtg gatgggctgg atcgacccct acaggagcga gatcaggtac      180

agccccagct tccagggcca ggtgaccatc agcgccgaca agagcatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggccagcgac accgccatgt actactgcgc cagggtgagc      300

agcgagccct tcgacagctg gggccagggc accctggtga ccgtgagcag cgccagcacc      360

aagggcccca gcgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcaccgcc      420

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaacagc      480

ggcgccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtgac cgtgcccagc agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga gggtggagcc caagagctgc      660

gacaagaccc acacctgccc cccctgcccc gcccccgagc tgctgggcgg ccccagcgtg      720

ttcctg                                                                 726


<210> 104
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 104
agctacgtgc tgacccagcc ccccagcgtg agcgtggccc ccggcaagac cgccaggatc       60

acctgcagcg gcgacaagct gggcgaccac tacgcctact ggtaccagca gaagcccggc      120

caggcccccg tgctggtgat ctacgacgac agcaagaggc ccagcggcat ccccgagagg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcagggt ggaggccggc      240

gacgaggccg actactactg cgccacctgg accttcgagg gcgactacgt gttcggcggc      300

ggcaccaagc tgaccgtgct gggccagccc aaggccgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggagctgca ggccaacaag gccaccctgg tgtgcctgat cagcgacttc      420

taccccggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg agctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaagaccgt ggcccccacc gagtgcagc                             639


<210> 105
<211> 756
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (694)..(756)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (703)..(705)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (706)..(756)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (724)..(756)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(756)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 105
caggtgcagc tgcagcagag cggccccggc ctggtgaagc ccagccagac cctgagcctg       60

acctgcgcca tcagcggcga cagcgtgagc agcaacaccg ccgcctggaa ctggatcagg      120

cagagcccca gcaggggcct ggagtggctg ggcgtgatct actacaggag caagtggtac      180

aacgactacg ccgtgagcgt gaagagcagg atcaccatca accccgacac cagcaagaac      240

cagttcagcc tgcagctgaa cagcgtgacc cccgaggaca ccgccgtgta ctactgcgcc      300

aggagcgtgc ccggcggcga ccccggcctg gagcacgcct tcgcctactg gggcaggggc      360

accctggtga ccgtgagcag cgccagcacc aagggcccca gcgtgttccc cctggccccc      420

agcagcaaga gcaccagcgg cggcaccgcc gccctgggct gcctggtgaa ggactacttc      480

cccgagcccg tgaccgtgag ctggaacagc ggcgccctga ccagcggcgt gcacaccttc      540

cccgccgtgc tgcagagcag cggcctgtac agcctgagca gcgtggtgac cgtgcccagc      600

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga gggtggagcc caagagctgc gacaagaccc acacctgccc cccctgcccc      720

gcccccgagc tgctgggcgg ccccagcgtg ttcctg                                756


<210> 106
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 106
agctacgtgc tgacccagcc ccccagcgtg agcgtggccc ccggcaagac cgccaggatc       60

acctgcagcg gcgacaacct gggcacctac tacgtggagt ggtaccagca gaagcccggc      120

caggcccccg tgctggtgat ctacgacgac agcgacaggc ccagcggcat ccccgagagg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcagggt ggaggccggc      240

gacgaggccg actactactg cgccagcttc gccagctgga gcgacagcgt gttcggcggc      300

ggcaccaagc tgaccgtgct gggccagccc aaggccgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggagctgca ggccaacaag gccaccctgg tgtgcctgat cagcgacttc      420

taccccggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg agctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaagaccgt ggcccccacc gagtgcagc                             639


<210> 107
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (610)..(642)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (628)..(642)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 107
acctgcaccg tgagcggcgg cagcatcagc agcggcgagt actactggaa ctggatcagg       60

cagcaccccg gcaagggcct ggagtggatc ggctacatct actacagcgg cagcacctac      120

tacaacccca gcctgaagag cagggtgacc atcagcgtgg acaccagcaa gaaccagttc      180

agcctgaagc tgagcagcgt gaccgccgcc gacaccgccg tgtactactg cgccagggag      240

agcgtggccg gcttcgacta ctggggccag ggcaccctgg tgaccgtgag cagcgccagc      300

accaagggcc ccagcgtgtt ccccctggcc ccctgcagca ggagcaccag cgagagcacc      360

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      420

agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      480

tacagcctga gcagcgtggt gaccgtgccc agcagcaact tcggcaccca gacctacacc      540

tgcaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga gaggaagtgc      600

tgcgtggagt gccccccctg ccccgccccc cccgtggccg gc                         642


<210> 108
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 108
gagatcgtgc tgacccagag ccccggcacc ctgagcctga gccccggcga gagggccacc       60

ctgagctgca gggccagcca gagcgtgagc agcagctacc tggcctggta ccagcagaag      120

cccggccagg cccccaggct gctgatctac ggcaccagca gcagggccac cggcatcccc      180

gacaggttca gcggcagcgg cagcggcacc gacttcaccc tgaccatcag caggctggag      240

cccgaggact tcgccgtgta ctactgccag cagtacggca gcagccccat caccttcggc      300

cagggcacca ggctggagat caagaggacc gtggccgccc ccagcgtgtt catcttcccc      360

cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctgct gaacaacttc      420

taccccaggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggagagcg tgaccgagca ggacagcaag gacagcacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      600

ggcctgagca gccccgtgac caagagcttc aacaggggcg agtgc                      645


<210> 109
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (661)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (670)..(672)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (673)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (691)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(723)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 109
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcagc agctacgcca tcagctgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcggc atcggcccct tcttcggcac cgccaactac      180

gcccagaagt tccagggcag ggtgaccatc accgccgacg agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cagggacacc      300

ccctacttcg actactgggg ccagggcacc ctggtgaccg tgagcagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg caccgccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgagctg gaacagcggc      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaggg tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgccccgcc cccgaggccg ccggcggccc cagcgtgttc      720

ctg                                                                    723


<210> 110
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 110
agctacgagc tgacccagcc cctgagcgtg agcgtggccc tgggccagac cgccaggatc       60

acctgcagcg gcgacagcat ccccaactac tacgtgtact ggtaccagca gaagcccggc      120

caggcccccg tgctggtgat ctacgacgac agcaacaggc ccagcggcat ccccgagagg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcagggc ccaggccggc      240

gacgaggccg actactactg ccagagcttc gacagcagcc tgaacgccga ggtgttcggc      300

ggcggcacca agctgaccgt gctgggccag cccaaggccg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctaccccg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggagctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaagac cgtggccccc accgagtgca gc                         642


<210> 111
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (667)..(729)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (676)..(678)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (679)..(729)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (697)..(729)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(729)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 111
gaggtgaagc tggaggagag cggcggcggc ctggtgcagc ccggcggcag catgaagctg       60

agctgcgccg ccagcggctt caccttcagc gacgcctgga tggactgggt gaggcagagc      120

cccgagaagg gcctggagtg ggtggccgag atcaggagca aggccagcaa ccacgccacc      180

tactacgccg agagcgtgaa gggcaggttc accatcagca gggacgacag caagagcagc      240

gtgtacctgc agatgaacag cctgagggcc gaggacaccg gcatctacta ctgcaccagg      300

tggaggaggt tcttcgacag ctggggccag ggcaccaccc tgaccgtgag cagcgccagc      360

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcacc      420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      480

agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      540

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      660

tgcgacaaga cccacacctg ccccccctgc cccgcccccg agctgctggg cggccccagc      720

gtgttcctg                                                              729


<210> 112
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 112
cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc       60

atgacctgca gggccagcag cagcgtgagc tacatgcact ggtaccagca gaagcccggc      120

agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgagg      180

ttcagcggca gcggcagcgg caccagctac agcctgacca tcagcagggt ggaggccgag      240

gacgccgcca cctactactg ccagcagtgg agcagcaacc ccctgacctt cggcgccggc      300

accaagctgg agctgaagag gaccgtggcc gcccccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

agggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg      600

agcagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210> 113
<211> 738
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (676)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (685)..(687)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (688)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (706)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(738)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 113
caggtgcagc tggtgcagag cggcgccgag ctgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaaga gcagcggcta ccacttcacc agctactgga tgcactgggt gaagcaggcc      120

cccggccagg gcctggagtg gatcggcgtg atccacccca acagcggcag catcaactac      180

aacgagaagt tcgagagcag ggtgaccatc accgtggaca agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cggcgagagg      300

gacagcaccg aggtgctgcc catggactac tggggccagg gcaccaccgt gaccgtgagc      360

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagggtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc      720

ggccccagcg tgttcctg                                                    738


<210> 114
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 114
gacgtgcaga tcacccagag ccccagcagc ctgagcgcca gcctgggcga gagggccacc       60

atcaactgca gggccagcaa gagcatcaac aagtacctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacagc ggcagcaccc tgcagagcgg catccccgcc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccatgtacta ctgccagcag cacaacgagt accccctgac cttcggccag      300

ggcaccaagc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 115
<211> 738
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (676)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (685)..(687)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (688)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (706)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(738)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 115
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcggctt caccttcgac gactacgcca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcgcc atcacctgga acagcggcca catcgactac      180

gccgacagcg tggagggcag gttcaccatc agcagggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caaggtgagc      300

tacctgagca ccgccagcag cctggactac tggggccagg gcaccctggt gaccgtgagc      360

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc      720

ggccccagcg tgttcctg                                                    738


<210> 116
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 116
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcatcagg aactacctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gccagcaccc tgcagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacgtgg ccacctacta ctgccagagg tacaacaggg ccccctacac cttcggccag      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 117
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (673)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (682)..(684)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (685)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (703)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(735)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 117
gaggtgaagc tggaggagag cggcggcggc ctggtgcagc ccggcggcag catgaagctg       60

agctgcgtgg ccagcggctt catcttcagc aaccactgga tgaactgggt gaggcagagc      120

cccgagaagg gcctggagtg ggtggccgag atcaggagca agagcatcaa cagcgccacc      180

cactacgccg agagcgtgaa gggcaggttc accatcagca gggacgacag caagagcgcc      240

gtgtacctgc agatgaccga cctgaggacc gaggacaccg gcgtgtacta ctgcagcagg      300

aactactacg gcagcaccta cgactactgg ggccagggca ccaccctgac cgtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgcg acaagaccca cacctgcccc ccctgccccg cccccgagct gctgggcggc      720

cccagcgtgt tcctg                                                       735


<210> 118
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 118
gacatcctgc tgacccagag ccccgccatc ctgagcgtga gccccggcga gagggtgagc       60

ttcagctgca gggccagcca gttcgtgggc agcagcatcc actggtacca gcagaggacc      120

aacggcagcc ccaggctgct gatcaagtac gccagcgaga gcatgagcgg catccccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga gcatcaacac cgtggagagc      240

gaggacatcg ccgactacta ctgccagcag agccacagct ggcccttcac cttcggcagc      300

ggcaccaacc tggaggtgaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 119
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (658)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (667)..(669)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (670)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (688)..(720)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(720)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 119
agcaagctgc aggtgcagct ggtggagagc ggcggcggcg tggtgcagcc cggcaggagc       60

ctgaggctga gctgcgccgc cagcggcttc atcttcagca gctacgccat gcactgggtg      120

aggcaggccc ccggcaacgg cctggagtgg gtggccttca tgagctacga cggcagcaac      180

aagaagtacg ccgacagcgt gaagggcagg ttcaccatca gcagggacaa cagcaagaac      240

accctgtacc tgcagatgaa cagcctgagg gccgaggaca ccgccgtgta ctactgcgcc      300

agggacaggg gcatcgccgc cggcggcaac tactactact acggcatgga cgtgtggggc      360

cagggcacca ccgtgaccgt gagcagcgcc agcaccaagg gccccagcgt gttccccctg      420

gcccccagca gcaagagcac cagcggcggc accgccgccc tgggctgcct ggtgaaggac      480

tacttccccg agcccgtgac cgtgagctgg aacagcggcg ccctgaccag cggcgtgcac      540

accttccccg ccgtgctgca gagcagcggc ctgtacagcc tgagcagcgt ggtgaccgtg      600

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaag      660

acccacacct gccccccctg ccccgccccc gagctgctgg gcggccccag cgtgttcctg      720


<210> 120
<211> 654
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 120
gccggcagcg agatcgtgct gacccagagc cccgccaccc tgagcctgag ccccggcgag       60

agggccaccc tgagctgcag ggccagccag agcgtgtaca gctacctggc ctggtaccag      120

cagaagcccg gccaggcccc caggctgctg atctacgacg ccagcaacag ggccaccggc      180

atccccgcca ggttcagcgg cagcggcagc ggcaccgact tcaccctgac catcagcagc      240

ctggagcccg aggacttcgc cgtgtactac tgccagcaga ggagcaactg gccccccttc      300

accttcggcc ccggcaccaa ggtggacatc aagaggaccg tggccgcccc cagcgtgttc      360

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg      420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaacagcc aggagagcgt gaccgagcag gacagcaagg acagcaccta cagcctgagc      540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      600

acccaccagg gcctgagcag ccccgtgacc aagagcttca acaggggcga gtgc            654


<210> 121
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (673)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (682)..(684)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (685)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (703)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(735)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 121
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc agccacggca tcagctgggt gaggcaggcc      120

cccggccagg gcctggactg gatgggctgg atcagcccct acagcggcaa caccaactac      180

gcccagaagc tgcagggcag ggtgaccatg accaccgaca ccagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cagggtgggc      300

agcggcccct actactacat ggacgtgtgg ggccagggca ccctggtgac cgtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgcg acaagaccca cacctgcccc ccctgccccg cccccgaggc cgccggcggc      720

cccagcgtgt tcctg                                                       735


<210> 122
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 122
cagagcgccc tgacccagcc caggagcgtg agcggcagcc ccggccagag cgtgaccatc       60

agctgcaccg gcaccagcag cagcgtgggc gacagcatct acgtgagctg gtaccagcag      120

caccccggca aggcccccaa gctgatgctg tacgacgtga ccaagaggcc cagcggcgtg      180

cccgacaggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctg      240

caggccgagg acgaggccga ctactactgc tacagctacg ccggcaccga caccctgttc      300

ggcggcggca ccaaggtgac cgtgctgggc cagcccaagg ccgcccccag cgtgaccctg      360

ttccccccca gcagcgagga gctgcaggcc aacaaggcca ccctggtgtg cctgatcagc      420

gacttctacc ccggcgccgt gaccgtggcc tggaaggccg acagcagccc cgtgaaggcc      480

ggcgtggaga ccaccacccc cagcaagcag agcaacaaca agtacgccgc cagcagctac      540

ctgagcctga cccccgagca gtggaagagc cacaggagct acagctgcca ggtgacccac      600

gagggcagca ccgtggagaa gaccgtggcc cccaccgagt gcagc                      645


<210> 123
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (673)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (682)..(684)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (685)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (703)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(735)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 123
caggtgcagc tgcaggagag cggccccggc ctggtgaagc ccagcgagac cctgagcctg       60

acctgcagcg tgagcggcgg cagcatcatc agcaggagca gctactgggg ctggatcagg      120

cagccccccg gcaagggcct ggagtggatc ggcggcatct accacagcgg caacacctac      180

gacaacccca gcctgaagag caggctgacc atgagcgtgg acaccagcaa gaaccagttc      240

agcctgaacc tgaggagcgt gaccgccgcc gacaccgccg tgtactactg cgccaggatc      300

gtgcccggcg gcgacgcctt cgacatctgg ggccagggca ccatggtgac cgtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagag ggtggagccc      660

aagagctgcg acaagaccca cacctgcccc ccctgccccg cccccgagct gctgggcggc      720

cccagcgtgt tcctg                                                       735


<210> 124
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 124
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

gcctgcaggg ccagccagag cgtgggcacc tacctgaact ggtaccagca gaagaggggc      120

aaggccccca agctgctgat cttcgccgcc agcagcctgc agagcggcgt gcccagcagg      180

ttcagcggca gcggcagcgg caccgacttc accctgacca tcagcagcct gcagcccgag      240

gacttcgcca cctactactg ccagcagagc tacagcagcc cccccacctt cggccagggc      300

accaaggtgg agatcaagag gaccgtggcc gcccccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

agggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg      600

agcagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210> 125
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (664)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (673)..(675)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (676)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (694)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(726)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 125
gaggtgcagc tggtggagag cggcggcggc ctgatccagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc aactacgcca tgagctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcagc atcagcagcg gcggcagcac ctactacccc      180

gacagcgtga agggcaggtt caccatcagc agggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagggc cgaggacacc gccgtgtact actgcgccag gtactactac      300

ggccagtact tcgacttctg gggccagggc accctggtga ccgtgagcag cgccagcacc      360

aagggcccca gcgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcaccgcc      420

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaacagc      480

ggcgccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtgac cgtgcccagc agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga gggtggagcc caagagctgc      660

gacaagaccc acacctgccc cccctgcccc gcccccgagc tgctgggcgg ccccagcgtg      720

ttcctg                                                                 726


<210> 126
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 126
gacatcgtga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca aggccagcca ggacgtgagc accaccgtgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacagc gccagctaca ggagcaccgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccgtgtacta ctgccagcag cactacagca cccccctgac cttcggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 127
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (661)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (669)..(672)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (673)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (691)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(723)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 127
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcagc agctacgcca tcagctgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcggc atcggcccct tcttcggcac cgccaactac      180

gcccagaagt tccagggcag ggtgaccatc accgccgacg agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc cagggacacc      300

ccctacttcg actactgggg ccagggcacc ctggtgaccg tgagcagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg caccgccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgagctg gaacagcggc      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaggg tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgccccgcc cccgaggccg ccggcggccc cagcgtgttc      720

ctg                                                                    723


<210> 128
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 128
agctacgagc tgacccagcc cctgagcgtg agcgtggccc tgggccagac cgccaggatc       60

acctgcagcg gcgacagcat ccccaactac tacgtgtact ggtaccagca gaagcccggc      120

caggcccccg tgctggtgat ctacgacgac agcaacaggc ccagcggcat ccccgagagg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcagggc ccaggccggc      240

gacgaggccg actactactg ccagagcttc gacagcagcc tgaacgccga ggtgttcggc      300

ggcggcacca agctgaccgt gctgggccag cccaaggccg cccccagcgt gaccctgttc      360

ccccccagca gcgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      420

ttctaccccg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggagctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaagac cgtggccccc accgagtgca gc                         642


<210> 129
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (673)..(705)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (691)..(705)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 129
caggtgcagc tgcaggagag cggccccggc ctggtgaagc ccagcgagac cctgagcctg       60

acctgcgccg tgagcggcca cagcatcagc cacgaccacg cctggagctg ggtgaggcag      120

ccccccggcg agggcctgga gtggatcggc ttcatcagct acagcggcat caccaactac      180

aaccccagcc tgcagggcag ggtgaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caggagcctg      300

gccaggacca ccgccatgga ctactggggc gagggcaccc tggtgaccgt gagcagcgcc      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg      480

aacagcggcg ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca acttcggcac ccagacctac      600

acctgcaacg tggaccacaa gcccagcaac accaaggtgg acaagaccgt ggagaggaag      660

agctgcgtgg agtgcccccc ctgccccgcc ccccccgtgg ccggc                      705


<210> 130
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 130
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagcgtgacc       60

atcacctgcc aggccagcac cgacatcagc agccacctga actggtacca gcagaagccc      120

ggcaaggccc ccgagctgct gatctactac ggcagccacc tgctgagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccttca ccatcagcag cctggaggcc      240

gaggacgccg ccacctacta ctgcggccag ggcaacaggc tgccctacac cttcggccag      300

ggcaccaagg tggagatcga gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 131
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (661)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (670)..(672)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (673)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (691)..(723)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(723)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 131
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcaggtt caccttcgac gactacgcca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcggc atcagctgga acagcggcag gatcggctac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acgccgagaa cagcctgttc      240

ctgcagatga acggcctgag ggccgaggac accgccctgt actactgcgc caagggcagg      300

gacagcttcg acatctgggg ccagggcacc atggtgaccg tgagcagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg caccgccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgagctg gaacagcggc      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgccccgcc cccgagctgc tgggcggccc cagcgtgttc      720

ctg                                                                    723


<210> 132
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 132
gacatccaga tgacccagag ccccagcagc gtgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcatcagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacggc gccagcagcc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccagctacta ctgccagcag gccaacagct tcccctacac cttcggccag      300

ggcaccaagc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 133
<211> 738
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (676)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (685)..(687)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (688)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (706)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(738)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 133
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc agcagctgga tgaactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcagg atctaccccg gcgacggcga caccaactac      180

aacgtgaagt tcaagggcag gttcaccatc agcagggacg acagcaagaa cagcctgtac      240

ctgcagatga acagcctgaa gaccgaggac accgccgtgt actactgcgc caggagcggc      300

ttcatcacca ccgtgaggga cttcgactac tggggccagg gcaccctggt gaccgtgagc      360

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagggtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc      720

ggccccagcg tgttcctg                                                    738


<210> 134
<211> 654
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 134
gagatcgtgc tgacccagag ccccgacttc cagagcgtga cccccaagga gaaggtgacc       60

atcacctgca gggccagcga gagcgtggac accttcggca tcagcttcat gaactggttc      120

cagcagaagc ccgaccagag ccccaagctg ctgatccacg aggccagcaa ccagggcagc      180

ggcgtgccca gcaggttcag cggcagcggc agcggcaccg acttcaccct gaccatcaac      240

agcctggagg ccgaggacgc cgccacctac tactgccagc agagcaagga ggtgcccttc      300

accttcggcg gcggcaccaa ggtggagatc aagaggaccg tggccgcccc cagcgtgttc      360

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg      420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaacagcc aggagagcgt gaccgagcag gacagcaagg acagcaccta cagcctgagc      540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      600

acccaccagg gcctgagcag ccccgtgacc aagagcttca acaggggcga gtgc            654


<210> 135
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (664)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (673)..(675)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (676)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (694)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(726)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 135
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt cttcatcacc aacaactact ggggctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggctac atcagctaca gcggcagcac cagctacaac      180

cccagcctga agagcaggtt caccatcagc agggacacca gcaagaacac cttctacctg      240

cagatgaaca gcctgagggc cgaggacacc gccgtgtact actgcgccag gaccggcagc      300

agcggctact tcgacttctg gggccagggc accctggtga ccgtgagcag cgccagcacc      360

aagggcccca gcgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcaccgcc      420

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaacagc      480

ggcgccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtgac cgtgcccagc agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc      660

gacaagaccc acacctgccc cccctgcccc gcccccgagc tgctgggcgg ccccagcgtg      720

ttcctg                                                                 726


<210> 136
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 136
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcga gagcgtggac gacctgctgc actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatcaagtac gccagccaga gcatcagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacagcc tgcccaacac cttcggccag      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 137
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (685)..(717)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (703)..(717)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 137
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc gactacaaca tgcactgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcgag atcaacccca acagcggcgg cgccggctac      180

aaccagaagt tcaagggcag ggtgaccatg accaccgaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag gagcgacgac accgccgtgt actactgcgc caggctgggc      300

tacgacgaca tctacgacga ctggtacttc gacgtgtggg gccagggcac caccgtgacc      360

gtgagcagcg ccagcaccaa gggccccagc gtgttccccc tggccccctg cagcaggagc      420

accagcgaga gcaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag caacttcggc      600

acccagacct acacctgcaa cgtggaccac aagcccagca acaccaaggt ggacaagacc      660

gtggagagga agtgctgcgt ggagtgcccc ccctgccccg ccccccccgt ggccggc         717


<210> 138
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 138
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca ggacatcagc aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcaggc tgctgagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcgacaccc tgccctacac cttcggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210> 139
<211> 741
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (679)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (688)..(690)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (691)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (709)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(741)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 139
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc cactacatca tgatgtgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcggc atctacagca gcggcggcat caccgtgtac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc ctacaggagg      300

atcggcgtgc ccaggaggga cgagttcgac atctggggcc agggcaccat ggtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagggtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc cgagctgctg      720

ggcggcccca gcgtgttcct g                                                741


<210> 140
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 140
gacatccaga tgacccagag ccccagcacc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gagcatcagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacaag gccagcaccc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag cctgcagccc      240

gacgacttcg ccacctacta ctgccagcag tacaacacct actggacctt cggccagggc      300

accaaggtgg agatcaagag gaccgtggcc gcccccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

agggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg      600

agcagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210> 141
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 141
atgtaccgga tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaatagc       60

gaagtccagc tgctggaatc tggcggcgga cttgttcaac ctggcggctc tctgagactg      120

agctgtgccg cttccggctt caccttcagc cactatatca tgatgtgggt ccgacaggcc      180

cctggcaaag gccttgaatg ggtgtccggc atctatagca gcggcggcat cacagtgtac      240

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      300

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcgc ctatagaaga      360

atcggcgtgc ccagacggga cgagttcgat atttggggcc agggcaccat ggtcaccgtg      420

tctagcgcct ctacaaaggg ccctagcgtg ttccctctgg ctcctagcag caagagcaca      480

agcggaggaa cagccgctct gggctgtctg gtcaaggact actttcccga gcctgtgacc      540

gtgtcctgga atagcggagc actgacaagc ggcgtgcaca cctttccagc tgtgctgcaa      600

agcagcggcc tgtactctct gagcagcgtg gtcacagtgc caagctctag cctgggcacc      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgcgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctc      780

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgcgt ggtggtggat gtgtcccacg aggatcccga agtgaagttc      900

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc     1080

atcagcaagg ccaagggcca gcctagggaa ccccaggttt acacactgcc tccaagccgg     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctcg tgaagggctt ctacccttcc     1200

gatatcgccg tggaatggga gagcaatggc cagccagaga acaactacaa gacaacccct     1260

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagtcc     1320

agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagtctgag cctgtctcca ggcctgcgga agagaagggc tcctgtgaag     1440

cagaccctga acttcgacct gctgaaactg gccggcgacg tggaaagcaa ccccggacct     1500

atgtatagaa tgcagctcct cctgctgatc gcactgagcc tggctctcgt gaccaacagc     1560

gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc     1620

atcacctgta gagccagcca gtccatctcc tcttggctgg cctggtatca gcaaaagcct     1680

ggcaaggccc ctaagctgct gatctacaag gcctccacac tggaaagcgg ggtgccctcc     1740

agattttctg gcagcggatc tggcaccgag ttcaccctga ccatcagtag cctgcagcct     1800

gacgacttcg ccacctacta ctgccagcag tacaatacct actggacctt cggccaggga     1860

acaaaggtgg aaatcaagcg gactgtggcc gctccaagcg tgttcatctt tccacctagc     1920

gacgagcagc tgaagtccgg cacagcctct gttgtgtgcc tgctgaacaa cttctacccc     1980

agagaagcca aggtgcagtg gaaagtggac aatgccctgc agagcggcaa ctcccaagag     2040

agcgtgacag agcaggactc caaggattcc acctacagcc tgtctagcac cctgacactg     2100

agcaaggccg actacgagaa gcacaaagtg tatgcctgcg aagtgaccca ccagggcctt     2160

agctctccag tgaccaagag cttcaaccgg ggcgagtgtt gataa                     2205


<210> 142

<400> 142
000


<210> 143
<211> 738
<212> PRT
<213> Adeno-associated virus 8

<400> 143
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 144
<211> 736
<212> PRT
<213> Adeno-associated virus 9

<400> 144
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 145
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 145
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 146
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 146
Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 147
<211> 26
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      VEGF-A signal peptide"

<400> 147
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala 
            20                  25      


<210> 148
<211> 29
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Fibulin-1 signal peptide"

<400> 148
Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210> 149
<211> 19
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Vitronectin signal peptide"

<400> 149
Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 150
<211> 18
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Complement Factor H signal peptide"

<400> 150
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala 
        


<210> 151
<211> 19
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Opticin signal peptide"

<400> 151
Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr 
            


<210> 152
<211> 18
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Albumin signal peptide"

<400> 152
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 153
<211> 18
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Chymotrypsinogen signal peptide"

<400> 153
Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210> 154
<211> 20
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Interleukin-2 signal peptide"

<400> 154
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 155
<211> 15
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Trypsinogen-2 signal peptide"

<400> 155
Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210> 156
<211> 17
<212> PRT
<213> Homo sapiens

<400> 156
Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210> 157
<211> 22
<212> PRT
<213> Homo sapiens

<400> 157
Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly 
            20          


<210> 158
<211> 19
<212> PRT
<213> Homo sapiens

<400> 158
Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210> 159
<211> 22
<212> PRT
<213> Homo sapiens

<400> 159
Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly 
            20          


<210> 160
<211> 18
<212> PRT
<213> Homo sapiens

<400> 160
Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly 
        


<210> 161
<211> 27
<212> PRT
<213> Homo sapiens

<400> 161
Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala 
            20                  25          


<210> 162
<211> 22
<212> PRT
<213> Homo sapiens

<400> 162
Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala 
            20          


<210> 163
<211> 19
<212> PRT
<213> Homo sapiens

<400> 163
Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys 
            


<210> 164
<211> 23
<212> PRT
<213> Homo sapiens

<400> 164
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala 
            20              


<210> 165
<211> 20
<212> PRT
<213> Homo sapiens

<400> 165
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala 
            20  


<210> 166
<211> 23
<212> PRT
<213> Homo sapiens

<400> 166
Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala 
            20              


<210> 167
<211> 31
<212> PRT
<213> Homo sapiens

<400> 167
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg 
            20                  25                  30      


<210> 168
<211> 15
<212> PRT
<213> Homo sapiens

<400> 168
Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala 
1               5                   10                  15  


<210> 169
<211> 17
<212> PRT
<213> Homo sapiens

<400> 169
Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala 
    


<210> 170
<211> 17
<212> PRT
<213> Homo sapiens

<400> 170
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala 
    


<210> 171
<211> 16
<212> PRT
<213> Homo sapiens

<400> 171
Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala 
1               5                   10                  15      


<210> 172
<211> 20
<212> PRT
<213> Homo sapiens

<400> 172
Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala 
            20  


<210> 173
<211> 18
<212> PRT
<213> Homo sapiens

<400> 173
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 174
<211> 24
<212> PRT
<213> Homo sapiens

<400> 174
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210> 175
<211> 18
<212> PRT
<213> Homo sapiens

<400> 175
Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala 
        


<210> 176
<211> 18
<212> PRT
<213> Homo sapiens

<400> 176
Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly 
        


<210> 177
<211> 27
<212> PRT
<213> Homo sapiens

<400> 177
Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala 
            20                  25          


<210> 178
<211> 28
<212> PRT
<213> Homo sapiens

<400> 178
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210> 179
<211> 20
<212> PRT
<213> Homo sapiens

<400> 179
Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser 
            20  


<210> 180
<211> 18
<212> PRT
<213> Homo sapiens

<400> 180
Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly 
        


<210> 181
<211> 18
<212> PRT
<213> Homo sapiens

<400> 181
Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly 
        


<210> 182
<211> 19
<212> PRT
<213> Homo sapiens

<400> 182
Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr 
            


<210> 183
<211> 30
<212> PRT
<213> Homo sapiens

<400> 183
Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser 
            20                  25                  30  


<210> 184
<211> 26
<212> PRT
<213> Homo sapiens

<400> 184
Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala 
            20                  25      


<210> 185
<211> 18
<212> PRT
<213> Homo sapiens

<400> 185
Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser 
        


<210> 186
<211> 23
<212> PRT
<213> Homo sapiens

<400> 186
Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala 
            20              


<210> 187
<211> 18
<212> PRT
<213> Homo sapiens

<400> 187
Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr 
        


<210> 188
<211> 20
<212> PRT
<213> Homo sapiens

<400> 188
Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser 
            20  


<210> 189
<211> 19
<212> PRT
<213> Homo sapiens

<400> 189
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly 
            


<210> 190
<211> 24
<212> PRT
<213> Homo sapiens

<400> 190
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser 
            20                  


<210> 191
<211> 29
<212> PRT
<213> Homo sapiens

<400> 191
Met Ile Ser Arg Met Glu Lys Met Thr Met Met Met Lys Ile Leu Ile 
1               5                   10                  15      


Met Phe Ala Leu Gly Met Asn Tyr Trp Ser Cys Ser Gly 
            20                  25                  


<210> 192
<211> 32
<212> PRT
<213> Homo sapiens

<400> 192
Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


<210> 193
<211> 19
<212> PRT
<213> Homo sapiens

<400> 193
Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210> 194
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 194
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210> 195
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 195
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210> 196
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 196
Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210> 197
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 197
Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210> 198
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 198
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210> 199
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 199
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210> 200
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 200
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210> 201
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 201
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210> 202
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 202
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210> 203
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 203
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210> 204
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 204
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210> 205
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 205
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210> 206
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 206
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210> 207
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 207
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210> 208
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 208
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210> 209
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 209
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210> 210
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 210
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210> 211
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 211
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210> 212
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 212
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210> 213
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 213
Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210> 214
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 214
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210> 215
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 215
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210> 216
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 216
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210> 217
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 217
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
1               5                   10              


<210> 218
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 218
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210> 219
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 219
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210> 220
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 220
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210> 221
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 221
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210> 222
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 222
Arg Lys Arg Arg 
1               


<210> 223
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 223
Arg Arg Arg Arg 
1               


<210> 224
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 224
Arg Arg Lys Arg 
1               


<210> 225
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 225
Arg Lys Lys Arg 
1               


<210> 226

<400> 226
000


<210> 227
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(3) 
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 227
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 228
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(3) 
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 228
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 229
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(3) 
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 229
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 230
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(3) 
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 230
Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
1               5                   10                  15      


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25          


<210> 231
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 231
Arg Lys Arg Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
1               5                   10                  15      


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25              


<210> 232
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 232
Cys Pro Pro Cys Pro Ala 
1               5       


<210> 233
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 233
Cys Pro Pro Cys Pro 
1               5   


<210> 234

<400> 234
000


<210> 235

<400> 235
000


<210> 236
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 236
Glu Asp Thr Ala Val Tyr Tyr 
1               5           


<210> 237
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 237
Tyr Cys Ala Ser Gly Asp Tyr Trp 
1               5               


<210> 238
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 238
Glu Asp Val Gly Val Tyr Tyr 
1               5           


<210> 239
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 239
Glu Asp Phe Ala Val Tyr Tyr 
1               5           


<210> 240
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 240
Glu Asp Ser Gly Ile Tyr Tyr 
1               5           


<210> 241
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 241
Asn Trp Glu Asp Tyr Trp 
1               5       


<210> 242
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 242
Glu Asp Phe Ala Thr Tyr Tyr 
1               5           


<210> 243
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 243
Asp Thr Ala Val Tyr Tyr 
1               5       


<210> 244
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 244
Tyr Tyr Gly Ala Phe Asp 
1               5       


<210> 245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 245
Glu Asp Glu Ala Asp Tyr Tyr 
1               5           


<210> 246
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 246
Tyr Tyr Tyr Gly Arg His Phe Asp 
1               5               


<210> 247
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 247
Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10      


<210> 248
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 248
Glu Asp Val Ala Val Tyr Tyr 
1               5           


<210> 249
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 249
Glu Asp Leu Ala Thr Tyr Tyr 
1               5           


<210> 250
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 250
Glu Asp Thr Ala Val Tyr 
1               5       


<210> 251
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 251
Asp Asp Phe Ala Thr Tyr Tyr 
1               5           


<210> 252
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 252
Asp Leu Ser Gly Tyr Tyr 
1               5       


<210> 253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 253
Glu Asp Val Ala Thr Tyr Tyr 
1               5           


<210> 254
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 254
Asp Thr Ala Met Tyr Tyr 
1               5       


<210> 255
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 255
Asp Glu Ala Asp Tyr Tyr 
1               5       


<210> 256
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 256
Thr Phe Glu Gly Asp Tyr Val Phe 
1               5               


<210> 257
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 257
Asp Asn Leu Gly Thr Tyr Tyr Val Glu 
1               5                   


<210> 258

<400> 258

000      


<210> 259
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 259
Asp Ser Ile Pro Asn Tyr 
1               5       


<210> 260
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 260
Tyr Cys Gln Ser Phe Asp 
1               5       


<210> 261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 261
Glu Asp Thr Gly Ile Tyr Tyr 
1               5           


<210> 262
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 262
Glu Asp Ala Ala Thr Tyr Tyr 
1               5           


<210> 263
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 263
Tyr Asn Glu Lys Phe Glu 
1               5       


<210> 264
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 264
Glu Asp Phe Ala Met Tyr Tyr 
1               5           


<210> 265
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 265
Phe Thr Phe Asp Asp Tyr Ala 
1               5           


<210> 266
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 266
Glu Asp Thr Gly Val Tyr Tyr 
1               5           


<210> 267
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 267
Glu Asp Ile Ala Asp Tyr Tyr 
1               5           


<210> 268
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 268
Tyr Tyr Tyr Gly Met Asp 
1               5       


<210> 269
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 269
Glu Leu Leu Ile Tyr Tyr 
1               5       


<210> 270
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 270
Glu Asp Thr Ala Leu Tyr Tyr 
1               5           


<210> 271
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 271
Glu Asp Phe Ala Ser Tyr Tyr 
1               5           


<210> 272
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 272
Asp Leu Leu His Trp Tyr 
1               5       


<210> 273
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 273
Asp Asp Thr Ala Val Tyr Tyr
1               5       


<210> 274
<211> 736
<212> PRT
<213> Adeno-associated virus 1

<400> 274
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 275
<211> 735
<212> PRT
<213> Adeno-associated virus 2

<400> 275
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 276
<211> 736
<212> PRT
<213> Adeno-associated virus 3

<400> 276
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 277
<211> 734
<212> PRT
<213> Adeno-associated virus 4

<400> 277
Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210> 278
<211> 724
<212> PRT
<213> Adeno-associated virus 5

<400> 278
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210> 279
<211> 736
<212> PRT
<213> Adeno-associated virus 6

<400> 279
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 280
<211> 737
<212> PRT
<213> Adeno-associated virus 7

<400> 280
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 281
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 281
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Gly Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Ser Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 282
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 282
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 283
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 283
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 284
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 284
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210> 285
<211> 229
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 285
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 286
<211> 2193
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 286
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      180

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      240

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      360

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagagcacc      480

agtggtggaa cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggggc tctgacttct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcaca      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcagaaaga gaagaggctc tggagaaggc     1440

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     1500

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     1560

acacagagcc cctccacact gtctgcatct gtgggagaca gagtgaccat cacctgtaga     1620

gccagccagt ctatctctag ctggctggcc tggtatcagc aaaagcctgg caaggcccct     1680

aagctgctga tctacaaggc cagcacactt gagtcagggg tgccctccag attttctggc     1740

tctggatctg gcacagagtt caccctgacc atcagctccc tgcagccaga tgactttgcc     1800

acctactact gccagcagta caatacctac tggacctttg gccagggaac aaaggtggaa     1860

atcaagagaa cagtggctgc cccatctgtg ttcatcttcc caccatctga tgaacagctg     1920

aagtctggca ctgcctctgt tgtgtgcctg ctgaacaact tttaccccag agaagccaag     1980

gtgcagtgga aagtggataa tgccctgcag tctggcaata gccaagaatc tgtgacagag     2040

caggactcca aggattccac ctacagcctg agcagcaccc tgacactgag caaggctgac     2100

tatgagaagc acaaagtgta tgcctgtgaa gtgacacacc agggactgag cagcccagtg     2160

accaagagct tcaacagggg agagtgctga taa                                  2193


<210> 287
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 287
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      180

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      240

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      360

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagagcacc      480

agtggtggaa cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggggc tctgacctct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcaca      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcagaaaga gaagaggatc aggggcccca     1440

gtgaagcaga ccctgaactt tgatctgctg aagctggctg gggatgttga gagcaaccct     1500

ggacctatgt ataggatgca actgctcctc ctgattgctc tgagcctggc tcttgtgacc     1560

aactctgaca tccagatgac acagagcccc tccacactgt ctgcatctgt gggagacaga     1620

gtgaccatca cctgtagagc cagccagtct atctcttcct ggctggcctg gtatcagcaa     1680

aagcctggca aggcccctaa gctgctgatc tacaaggcca gcacacttga gtcaggggtg     1740

ccctccagat tttctggctc tggatctggc acagagttca ccctgaccat cagctccctg     1800

cagccagatg actttgccac ctactactgc cagcagtaca atacctactg gacctttggc     1860

cagggaacaa aggtggaaat caagagaaca gtggctgccc catctgtgtt catcttccca     1920

ccatctgatg aacagctgaa gtctggcact gcctctgttg tgtgcctgct gaacaacttt     1980

taccctagag aagccaaggt gcagtggaaa gtggataatg ccctgcagtc tggcaatagc     2040

caagaatctg tgacagagca ggactccaag gattccacct acagcctgag cagcaccctg     2100

acactgagca aggctgacta tgagaagcac aaagtgtatg cctgtgaagt gacacaccag     2160

ggactgagca gcccagtgac caagagcttc aacaggggag agtgctgata a              2211


<210> 288
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 288
Leu Gly Glu Thr Thr Arg Pro 
1               5           


<210> 289
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 289
Leu Ala Leu Gly Glu Thr Thr Arg Pro 
1               5                   


<210> 290
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 290
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 291
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 291
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 292
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 292
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210> 293
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 293
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 294
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 294
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 295
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 295
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 296
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 296
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 297
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 297
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 298
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 298
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210> 299
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 299
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 300
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 300
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                85                  90                  95      


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            100                 105                 110         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        115                 120                 125             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    130                 135                 140                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
145                 150                 155                 160 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                165                 170                 175     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            180                 185                 190         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        195                 200                 205             


Gly Lys 
    210 


<210> 301
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 301
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 302
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 302
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 303
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 303
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 304
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 304
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 305
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 305
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 306
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 306
Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 307
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 307
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 308
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 308
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 309
<211> 208
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 309
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            20                  25                  30          


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                85                  90                  95      


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            100                 105                 110         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        115                 120                 125             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    130                 135                 140                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
145                 150                 155                 160 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                165                 170                 175     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            180                 185                 190         


Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        195                 200                 205             


<210> 310
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 310
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 311
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 311
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 312
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 312
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 


<210> 313
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 313
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                85                  90                  95      


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            100                 105                 110         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        115                 120                 125             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    130                 135                 140                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
145                 150                 155                 160 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                165                 170                 175     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            180                 185                 190         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        195                 200                 205             


Gly Lys 
    210 


<210> 314
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 314
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 


<210> 315
<211> 969
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 315
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagt                                                              969


<210> 316
<211> 1050
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 316
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt                                      1050


<210> 317
<211> 1089
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 317
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagt                                                             1089


<210> 318
<211> 1430
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 318
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagcc cttaagctag caggttaatt tttaaaaagc      360

agtcaaaagt ccaagtggcc cttggcagca tttactctct ctgtttgctc tggttaataa      420

tctcaggagc acaaacattc cagatccagg ttaattttta aaaagcagtc aaaagtccaa      480

gtggcccttg gcagcattta ctctctctgt ttgctctggt taataatctc aggagcacaa      540

acattccaga tccggcgcgc cagggctgga agctaccttt gacatcattt cctctgcgaa      600

tgcatgtata atttctacag aacctattag aaaggatcac ccagcctctg cttttgtaca      660

actttccctt aaaaaactgc caattccact gctgtttggc ccaatagtga gaactttttc      720

ctgctgcctc ttggtgcttt tgcctatggc ccctattctg cctgctgaag acactcttgc      780

cagcatggac ttaaacccct ccagctctga caatcctctt tctcttttgt tttacatgaa      840

gggtctggca gccaaagcaa tcactcaaag ttcaaacctt atcatttttt gctttgttcc      900

tcttggcctt ggttttgtac atcagctttg aaaataccat cccagggtta atgctggggt      960

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag     1020

atgttgcttt ctgagaggat cttgctacca gtggaacagc cactaaggat tctgcagtga     1080

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1140

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1200

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1260

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1320

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1380

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1430


<210> 319
<211> 1318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 319
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagta aaacaggtaa gtccgctgtt tgtgtgctgc ctctgaagtc cacactgaac     1140

aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac     1200

acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggc     1260

ctctactaac catgttcatg ttttcttttt ttttctacag gtcctgggtg acgaacag       1318


<210> 320
<211> 1579
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 320
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagt                                                  1579


<210> 321
<211> 1080
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 321
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtctaga ggccgtccgc      360

cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg tggggagtta      420

tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa aaataactcc      480

cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac ggttcctcac      540

ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg gccgggcggt      600

gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag ctacccggag      660

gagcgggagg cgccaagcgt gagtatcgat cttgctacca gtggaacagc cactaaggat      720

tctgcagtga gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg      780

ccaccccctc caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct      840

ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg      900

ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg      960

accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat     1020

acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt     1080


<210> 322
<211> 568
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 322
gaatggtgga cacccaaata tggcgacggt tcctcacccg tcgccatatt tgggtgtccg       60

ccctcggccg gggccgcatt cctgggggcc gggcggtgct cccgcccgcc tcgataaaag      120

gctccggggc cggcggcggc ccacgagcta cccggaggag cgggaggcgc caagcgatct      180

tgctaccagt ggaacagcca ctaaggattc tgcagtgaga gcagagggcc agctaagtgg      240

tactctccca gagactgtct gactcacgcc accccctcca ccttggacac aggacgctgt      300

ggtttctgag ccaggtacag tgactccttt cggtaagtgc agtggaagct gtacactgcc      360

caggcaaagc gtccgggcag cgtaggcggg cgactcagat cccagccagt ggacttagcc      420

cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc agcctccccc      480

gttgcccctc tggatccact gcttaaatac ggacgaggac agggccctgt ctcctcagct      540

tcaggcacca ccactgacct gggacagt                                         568


<210> 323
<211> 895
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 323
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagaa tggtggacac ccaaatatgg cgacggttcc      360

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg      420

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc      480

ggaggagcgg gaggcgccaa gcgatcttgc taccagtgga acagccacta aggattctgc      540

agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac tcacgccacc      600

ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacagtga ctcctttcgg      660

taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt aggcgggcga      720

ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg gggtgacctt      780

ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct taaatacgga      840

cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg acagt           895


<210> 324
<211> 1291
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 324
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccctg catgcgaaga      480

tcttcgaaca aggctgtggg ggactgaggg caggctgtaa caggcttggg ggccagggct      540

tatacgtgcc tgggactccc aaagtattac tgttccatgt tcccggcgaa gggccagctg      600

tcccccgcca gctagactca gcacttagtt taggaaccag tgagcaagtc agcccttggg      660

gcagcccata caaggccatg gggctgggca agctgcacgc ctgggtccgg ggtgggcacg      720

gtgcccgggc aacgagctga aagctcatct gctctcaggg gcccctccct ggggacagcc      780

cctcctggct agtcacaccc tgtaggctcc tctatataac ccaggggcac aggggctgcc      840

ctcattctac caccacctcc acagcacaga cagacactca ggagccagcc agcgtcgaga      900

tcttgctacc agtggaacag ccactaagga ttctgcagtg agagcagagg gccagctaag      960

tggtactctc ccagagactg tctgactcac gccaccccct ccaccttgga cacaggacgc     1020

tgtggtttct gagccaggta cagtgactcc tttcggtaag tgcagtggaa gctgtacact     1080

gcccaggcaa agcgtccggg cagcgtaggc gggcgactca gatcccagcc agtggactta     1140

gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc agcagcctcc     1200

cccgttgccc ctctggatcc actgcttaaa tacggacgag gacagggccc tgtctcctca     1260

gcttcaggca ccaccactga cctgggacag t                                    1291


<210> 325
<211> 1147
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 325
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccctgcatg cgaagatctt cgaacaaggc tgtgggggac      360

tgagggcagg ctgtaacagg cttgggggcc agggcttata cgtgcctggg actcccaaag      420

tattactgtt ccatgttccc ggcgaagggc cagctgtccc ccgccagcta gactcagcac      480

ttagtttagg aaccagtgag caagtcagcc cttggggcag cccatacaag gccatggggc      540

tgggcaagct gcacgcctgg gtccggggtg ggcacggtgc ccgggcaacg agctgaaagc      600

tcatctgctc tcaggggccc ctccctgggg acagcccctc ctggctagtc acaccctgta      660

ggctcctcta tataacccag gggcacaggg gctgccctca ttctaccacc acctccacag      720

cacagacaga cactcaggag ccagccagcg tcgagatctt gctaccagtg gaacagccac      780

taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg      840

actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacagt      900

gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc      960

gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac     1020

tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg     1080

cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg     1140

ggacagt                                                               1147


<210> 326
<211> 1490
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 326
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gcccttcaga ttaaaaataa ctgaggtaag ggcctgggta      360

ggggaggtgg tgtgagacgc tcctgtctct cctctatctg cccatcggcc ctttggggag      420

gaggaatgtg cccaaggact aaaaaaaggc catggagcca gaggggcgag ggcaacagac      480

ctttcatggg caaaccttgg ggccctgctg aagctttggc ccactacggg tttaggctgc      540

ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt aacccagaca      600

tgtggctgcc cccccccccc ccaacacctg ctgcctctaa aaataaccct gtccctggtg      660

gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg gactgagggc aggctgtaac      720

aggcttgggg gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt      780

cccggcgaag ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt      840

gagcaagtca gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc      900

tgggtccggg gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg      960

cccctccctg gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc     1020

caggggcaca ggggctgccc tcattctacc accacctcca cagcacagac agacactcag     1080

gagccagcca gcgtcgagat cttgctacca gtggaacagc cactaaggat tctgcagtga     1140

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1200

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1260

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1320

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1380

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1440

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1490


<210> 327
<211> 969
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 327
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagt                                                              969


<210> 328
<211> 2074
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 328
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gcacacatac acgaacacac atacatatac atacattcac      360

atatatgcac acacatacac atatacacgc atacacgtac acacaaatgc acactcacac      420

atgcacacac atacataata tacacactct cacacatgca catacacaca tacatacaca      480

tacatgtgca tgcacacaca caaatacaca tgcatacatc cacattcaca cagatgcaga      540

cacaaatgca cacacacaca cacacacaca cacacacaca cacacacaca cgcacactgc      600

caccctgaac tagtggtggc taaatgaaca ataagtctcc atcaccagct tggggggagg      660

taggtggtag tgtaggtgcc cccattgtgt gatcatgttc attgtatgag tttgtctgtg      720

ttcattcatc atagtgacag tccccatgtg ggtagcagag agtacgtgtg catgcatcat      780

ctccgtgttt gctcatgagt gtgtatgtca gtgtgttcca gtctttctgt gtgagtgtcg      840

tccccaatcc cccatccccc cccccagatc tctaattagt ggtttggggt ttgttccttt      900

tccctcctgt tcctttcctc agcagcgcgg cagcagcggc ggcagcctcg gtggtagcag      960

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcaacagaa gctgccgcgc     1020

cgctgagtag cagcaaggac tccgagtcaa gagtaggatt gtaggattgg atctgagtgg     1080

gaacaagagt gagctggcct gagagaggag cagatgcctc ccagcgccct caggccaccc     1140

attgccagta atcttcaagc cagacctctt gagaggagac gggacagcca accctagcct     1200

acccaggtac agacactggg cagttctggg ggactgccca cagatgccta ttggattcct     1260

ggggtatgta ggactcccgg gtctaccagc ccttttcacc tttccccata gcacccccaa     1320

ggaagctctg acaacttgcc catattcctg tttcccaccc gtcccctggg cacccccttt     1380

tcttctctcc ctcccagatc ccttctttgg ggagctcagc aaatggagca ggaaatttgg     1440

accctctgcc tccctctctc gccttcctca ttggatccgg agtcttctcc gctgggaaag     1500

ctgtaattag agggtggatc cctacagaca gagagcagcc cccccacccc caccccccag     1560

tcccttctaa ctttagatct cttctctccc attctcccat tctccctccc tctcccttct     1620

ccctctccca ctggctcctc ggttctctcc atctgcctga ctccttggga cccggtcccc     1680

agatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct     1740

aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga     1800

cgctgtggtt tctgagccag gtacagtgac tcctttcggt aagtgcagtg gaagctgtac     1860

actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac     1920

ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc     1980

tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc     2040

tcagcttcag gcaccaccac tgacctggga cagt                                 2074


<210> 329
<211> 1360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 329
cacacataca cgaacacaca tacatataca tacattcaca tatatgcaca cacatacaca       60

tatacacgca tacacgtaca cacaaatgca cactcacaca tgcacacaca tacataatat      120

acacactctc acacatgcac atacacacat acatacacat acatgtgcat gcacacacac      180

aaatacacat gcatacatcc acattcacac agatgcagac acaaatgcac acacacacac      240

acacacacac acacacacac acacacacac gcacactgcc accctgaact agtggtggct      300

aaatgaacaa taagtctcca tcaccagctt ggggggaggt aggtggtagt gtaggtgccc      360

ccattgtgtg atcatgttca ttgtatgagt ttgtctgtgt tcattcatca tagtgacagt      420

ccccatgtgg gtagcagaga gtacgtgtgc atgcatcatc tccgtgtttg ctcatgagtg      480

tgtatgtcag tgtgttccag tctttctgtg tgagtgtcgt ccccaatccc ccatcccccc      540

ccccagatct ctaattagtg gtttggggtt tgttcctttt ccctcctgtt cctttcctca      600

gcagcgcggc agcagcggcg gcagcctcgg tggtagcagc agcagcagca gcagcagcag      660

cagcagcagc agcagcagca gcaacagaag ctgccgcgcc gctgagtagc agcaaggact      720

ccgagtcaag agtaggattg taggattgga tctgagtggg aacaagagtg agctggcctg      780

agagaggagc agatgcctcc cagcgccctc aggccaccca ttgccagtaa tcttcaagcc      840

agacctcttg agaggagacg ggacagccaa ccctagccta cccaggtaca gacactgggc      900

agttctgggg gactgcccac agatgcctat tggattcctg gggtatgtag gactcccggg      960

tctaccagcc cttttcacct ttccccatag cacccccaag gaagctctga caacttgccc     1020

atattcctgt ttcccacccg tcccctgggc accccctttt cttctctccc tcccagatcc     1080

cttctttggg gagctcagca aatggagcag gaaatttgga ccctctgcct ccctctctcg     1140

ccttcctcat tggatccgga gtcttctccg ctgggaaagc tgtaattaga gggtggatcc     1200

ctacagacag agagcagccc ccccaccccc accccccagt cccttctaac tttagatctc     1260

ttctctccca ttctcccatt ctccctccct ctcccttctc cctctcccac tggctcctcg     1320

gttctctcca tctgcctgac tccttgggac ccggtcccca                           1360


<210> 330
<211> 756
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 330
cgcggcagca gcggcggcag cctcggtggt agcagcagca gcagcagcag cagcagcagc       60

agcagcagca gcagcagcaa cagaagctgc cgcgccgctg agtagcagca aggactccga      120

gtcaagagta ggattgtagg attggatctg agtgggaaca agagtgagct ggcctgagag      180

aggagcagat gcctcccagc gccctcaggc cacccattgc cagtaatctt caagccagac      240

ctcttgagag gagacgggac agccaaccct agcctaccca ggtacagaca ctgggcagtt      300

ctgggggact gcccacagat gcctattgga ttcctggggt atgtaggact cccgggtcta      360

ccagcccttt tcacctttcc ccatagcacc cccaaggaag ctctgacaac ttgcccatat      420

tcctgtttcc cacccgtccc ctgggcaccc ccttttcttc tctccctccc agatcccttc      480

tttggggagc tcagcaaatg gagcaggaaa tttggaccct ctgcctccct ctctcgcctt      540

cctcattgga tccggagtct tctccgctgg gaaagctgta attagagggt ggatccctac      600

agacagagag cagccccccc acccccaccc cccagtccct tctaacttta gatctcttct      660

ctcccattct cccattctcc ctccctctcc cttctccctc tcccactggc tcctcggttc      720

tctccatctg cctgactcct tgggacccgg tcccca                                756


<210> 331
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (224)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Leu"

<220>
<221> SITE
<222> (228)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (234)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(244)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 331
Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Leu Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210> 332
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 332
Gln Ile Val Leu Ile Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 333
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (225)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Leu"

<220>
<221> SITE
<222> (229)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (235)..(245)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(245)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 333
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Tyr Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Gly Ser Asp Glu Thr Ala Tyr Ala Thr Ser Ala Ile 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asp Ser Ser Asp Trp Asp Ala Lys Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210> 334
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 334
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Glu 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Arg Asn 
                85                  90                  95      


Ile Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210> 335
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (224)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Leu"

<220>
<221> SITE
<222> (228)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (234)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(244)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 335
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210> 336
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 336
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ile Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 337
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (223)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Ser"

<220>
<221> SITE
<222> (232)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(242)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 337
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Met Arg Asn Lys Asn Tyr Gln Tyr Gly Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Leu Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Ser Tyr Tyr Gly Phe Thr Ser Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210> 338
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 338
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Ile Ser 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 339
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (227)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (230)..(230)
<223> /replace="Leu"

<220>
<221> SITE
<222> (231)..(247)
<223> /note="This region may be absent in its entirety"

<220> 
<221> SITE
<222> (237)..(247)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(247)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 339
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Arg 
            20                  25                  30          


Tyr Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Asp Tyr Asp Gly Asp Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Trp Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Pro Asp Val Val Thr Gly Phe His Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210> 340
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 340
Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Ala Asn Asn Asp Ile Gly Thr Tyr 
            20                  25                  30          


Ala Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Lys Val Thr Thr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Asn Phe 
                85                  90                  95      


Asn Asn Ala Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210> 341
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (224)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Leu"

<220>
<221> SITE
<222> (228)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (234)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(244)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 341
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210> 342
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 342
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 343
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (670)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (679)..(681)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (682)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (700)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(732)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 343
gaagtgcagc tggtggaaag cggcggcaaa ctgctgaaac cgggcggcag cctgaaactg       60

agctgcgcgg cgagcggctt tacctttagc agctttgcga tgagctggtt tcgccagagc      120

ccggaaaaac gcctggaatg ggtggcggaa attagcagcg gcggcagcta tacctattat      180

ccggataccg tgaccggccg ctttaccatt agccgcgata acgcgaaaaa caccctgtat      240

ctggaaatga gcagcctgcg cagcgaagat accgcgatgt attattgcgc gcgcggcctg      300

tggggctatt atgcgctgga ttattggggc cagggcacca gcgtgaccgt gagcagcgcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210> 344
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 344
cagattgtgc tgattcagag cccggcgatt atgagcgcga gcccgggcga aaaagtgacc       60

atgacctgca gcgcgagcag cagcgtgagc tatatgtatt ggtatcagca gaaaccgggc      120

agcagcccgc gcctgctgat ttatgatacc agcaacctgg cgagcggcgt gccggtgcgc      180

tttagcggca gcggcagcgg caccagctat agcctgacca ttagccgcat ggaagcggaa      240

gatgcggcga cctattattg ccagcagtgg agcggctatc cgtatacctt tggcggcggc      300

accaaactgg aaattaaacg caccgtggcg gcgccgagcg tgtttatttt tccgccgagc      360

gatgaacagc tgaaaagcgg caccgcgagc gtggtgtgcc tgctgaacaa cttttatccg      420

cgcgaagcga aagtgcagtg gaaagtggat aacgcgctgc agagcggcaa cagccaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccctg      540

agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcagggcctg      600

agcagcccgg tgaccaaaag ctttaaccgc ggcgaatgc                             639


<210> 345
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (673)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (682)..(684)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (685)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (703)..(735)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(735)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 345
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tagcctgagc aactattatg tgacctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgggcatt atttatggca gcgatgaaac cgcgtatgcg      180

accagcgcga ttggccgctt taccattagc cgcgataaca gcaaaaacac cctgtatctg      240

cagatgaaca gcctgcgcgc ggaagatacc gcggtgtatt attgcgcgcg cgatgatagc      300

agcgattggg atgcgaaatt taacctgtgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca aaggcccgag cgtgtttccg ctggcgccga gcagcaaaag caccagcggc      420

ggcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      540

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg cacccagacc      600

tatatttgca acgtgaacca taaaccgagc aacaccaaag tggataaacg cgtggaaccg      660

aaaagctgcg ataagaccca cacctgcccc ccctgccccg cccccgagct gctgggcggc      720

cccagcgtgt tcctg                                                       735


<210> 346
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (670)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (679)..(681)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (682)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (700)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(732)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 346
gcgattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc aggcgagcca gagcattaac aacgaactga gctggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatcgc gcgagcaccc tggcgagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gatgattttg cgacctatta ttgccagcag ggctatagcc tgcgcaacat tgataacgcg      300

tttggcggcg gcaccaaagt ggaaattaaa cgcaccgtgg cggcgccgag cgtgtttatt      360

tttccgccga gcgatgaaca gctgaaaagc ggcaccgcga gcgtggtgtg cctgctgaac      420

aacttttatc cgcgcgaagc gaaagtgcag tggaaagtgg ataacgcgct gcagagcggc      480

aacagccagg aaagcgtgac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc ggattatgaa aaacataaag tgtatgcgtg cgaagtgacc      600

catcagggcc tgagcagccc ggtgaccaaa agctttaacc gcggcgaatg cgaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210> 347
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (670)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (679)..(681)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (682)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (700)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(732)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 347
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc ccgtttgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgaaa attagcccgg gcggcagctg gacctattat      180

agcgataccg tgaccggccg ctttaccatt agccgcgata acgcgaaaaa cagcctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagctg      300

tggggctatt atgcgctgga tatttggggc cagggcacca ccgtgaccgt gagcagcgcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210> 348
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 348
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgca gcgcgagcat tagcgtgagc tatatgtatt ggtatcagca gaaaccgggc      120

caggcgccgc gcctgctgat ttatgatatg agcaacctgg cgagcggcat tccggcgcgc      180

tttagcggca gcggcagcgg caccgatttt accctgacca ttagcagcct ggaaccggaa      240

gattttgcgg tgtattattg catgcagtgg agcggctatc cgtatacctt tggcggcggc      300

accaaagtgg aaattaaacg caccgtggcg gcgccgagcg tgtttatttt tccgccgagc      360

gatgaacagc tgaaaagcgg caccgcgagc gtggtgtgcc tgctgaacaa cttttatccg      420

cgcgaagcga aagtgcagtg gaaagtggat aacgcgctgc agagcggcaa cagccaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccctg      540

agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcagggcctg      600

agcagcccgg tgaccaaaag ctttaaccgc ggcgaatgc                             639


<210> 349
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (667)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (682)..(683)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (694)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(726)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 349
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt taactttaac gattatttta tgaactgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgcag atgcgcaaca aaaactatca gtatggcacc      180

tattatgcgg aaagcctgga aggccgcttt accattagcc gcgatgatag caaaaacagc      240

ctgtatctgc agatgaacag cctgaaaacc gaagataccg cggtgtatta ttgcgcgcgc      300

gaaagctatt atggctttac cagctattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca aaggcccgag cgtgtttccg ctggcgccgt gcagccgcag caccagcgaa      420

agcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      540

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg caccaaaacc      600

tatacctgca acgtggatca taaaccgagc aacaccaaag tggataaacg cgtggagagc      660

aagtacggcc ccccctgccc cccctgcccc gcccccgagt tcctgggcgg ccccagcgtg      720

ttcctg                                                                 726


<210> 350
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 350
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc aggcgagcca ggatattggc attagcctga gctggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttataac gcgaacaacc tggcggatgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgcctgcag cataacagcg cgccgtatac ctttggccag      300

ggcaccaaac tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210> 351
<211> 741
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (679)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (688)..(690)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (691)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (709)..(741)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(741)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 351
gaagtgcagc tgcaggaaag cggcccgggc ctggtgaaac cgagccagac cctgagcctg       60

acctgcaccg tgagcggcgg cagcattacc agccgctatt atgcgtggag ctggattcgc      120

cagccgccgg gcaaaggcct ggaatggatt ggcgtgattg attatgatgg cgatacctat      180

tatagcccga gcctgaaaag ccgcgtgagc attagctggg ataccagcaa aaaccagttt      240

agcctgaaac tgagcagcgt gaccccggcg gataccgcgg tgtattattg cgcgcgcgat      300

ccggatgtgg tgaccggctt tcattatgat tattggggcc agggcaccat ggtgaccgtg      360

agcagcgcga gcaccaaagg cccgagcgtg tttccgctgg cgccgagcag caaaagcacc      420

agcggcggca ccgcggcgct gggctgcctg gtgaaagatt attttccgga accggtgacc      480

gtgagctgga acagcggcgc gctgaccagc ggcgtgcata cctttccggc ggtgctgcag      540

agcagcggcc tgtatagcct gagcagcgtg gtgaccgtgc cgagcagcag cctgggcacc      600

cagacctata tttgcaacgt gaaccataaa ccgagcaaca ccaaagtgga taaaaaagtg      660

gaaccgaaaa gctgcgataa gacccacacc tgccccccct gccccgcccc cgagctgctg      720

ggcggcccca gcgtgttcct g                                                741


<210> 352
<211> 648
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 352
cagagcgcgc tgacccagcc gccgagcgtg agcggcaccc cgggccagag cgtgaccatt       60

agctgcgcgg gcgcgaacaa cgatattggc acctatgcgt atgtgagctg gtatcagcag      120

ctgccgggca ccgcgccgaa actgatgatt tataaagtga ccacccgcgc gagcggcatt      180

ccggatcgct ttagcggcag caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caggcggaag atgaagcgga ttattattgc gcgagctatc gcaactttaa caacgcggtg      300

tttggcaccg gcaccaaact gaccgtgctg ggccagccga aagcggcgcc gagcgtgacc      360

ctgtttccgc cgagcagcga agaactgcag gcgaacaaag cgaccctggt gtgcctgatt      420

agcgattttt atccgggcgc ggtgaccgtg gcgtggaaag cggatagcag cccggtgaaa      480

gcgggcgtgg aaaccaccac cccgagcaaa cagagcaaca acaaatatgc ggcgagcagc      540

tatctgagcc tgaccccgga acagtggaaa agccatcgca gctatagctg ccaggtgacc      600

catgaaggca gcaccgtgga aaaaaccgtg gcgccgaccg aatgcagc                   648


<210> 353
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (670)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (679)..(681)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (682)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (700)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(732)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 353
caggtgcagc tgcaggaaag cggcccgggc ctggtgcgcc cgagccagac cctgagcctg       60

acctgcaccg tgagcggcta tagcattacc agcgatcatg cgtggagctg ggtgcgccag      120

ccgccgggcc gcggcctgga atggattggc tatattagct atagcggcat taccacctat      180

aacccgagcc tgaaaagccg cgtgaccatg ctgcgcgata ccagcaaaaa ccagtttagc      240

ctgcgcctga gcagcgtgac cgcggcggat accgcggtgt attattgcgc gcgcagcctg      300

gcgcgcacca ccgcgatgga ttattggggc cagggcagcc tggtgaccgt gagcagcgcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210> 354
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 354
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcca ggatattagc agctatctga actggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttattat accagccgcc tgcatagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccttta ccattagcag cctgcagccg      240

gaagatattg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggccag      300

ggcaccaaag tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210> 355
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 355
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 356
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 356
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 357
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 357
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 358
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 358
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210> 359
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 359
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 


<210> 360
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (229)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (233)..(249)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (239)..(249)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 360
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Gly Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Arg Ser Tyr Tyr Thr Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 


<210> 361
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 361
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Ala Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 362
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (228)..(238)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (234)..(238)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 362
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Ile Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly His Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235             


<210> 363
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 363
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 364
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (226)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Leu"

<220>
<221> SITE
<222> (230)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (236)..(246)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(246)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 364
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Ala Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ser Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Arg Glu Gly Ile Arg Tyr Tyr Gly Leu Leu Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu 
                245     


<210> 365
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 365
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Thr Ser Glu Asp Ile Ile Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 366
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (219)..(238)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Ser"

<220>
<221> SITE
<222> (228)..(238)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(238)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 366
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Trp Ser Asn Gly Asp Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Tyr Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235             


<210> 367
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 367
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 368
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (225)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (230)..(230)
<223> /replace="Ser"

<220>
<221> SITE
<222> (234)..(244)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(244)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 368
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210> 369
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 369
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 370
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (227)..(237)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (233)..(237)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 370
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ile Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Pro Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Asp Asp Gly Pro Tyr Thr Leu Glu Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235         


<210> 371
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 371
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Phe 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Gln Thr Glu Ala Gln Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Asp Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 372
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (222)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Leu"

<220>
<221> SITE
<222> (226)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (232)..(242)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (1)..(242)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 372
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210> 373
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 373
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg 
    210                 215 


<210> 374
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (228)..(238)
<223> /note="This region may be absent in its entirety"

<220>
<221> SITE
<222> (234)..(238)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 374
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Gln Trp Glu Leu Val His Glu Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235             


<210> 375
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 375
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Leu Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Trp Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Gly Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 376
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (685)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (694)..(696)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (697)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (715)..(747)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(747)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 376
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcagcg cgagcggctt tacctttagc agctttggca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgtat attagcagcg gcagcagcac catttattat      180

ggcgataccg tgaaaggccg ctttaccatt agccgcgata acgcgaaaaa cagcctgttt      240

ctgcagatga gcagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgaaggc      300

ggctattatt atggccgcag ctattatacc atggattatt ggggccaggg caccaccgtg      360

accgtgagca gcgcgagcac caaaggcccg agcgtgtttc cgctggcgcc gagcagcaaa      420

agcaccagcg gcggcaccgc ggcgctgggc tgcctggtga aagattattt tccggaaccg      480

gtgaccgtga gctggaacag cggcgcgctg accagcggcg tgcatacctt tccggcggtg      540

ctgcagagca gcggcctgta tagcctgagc agcgtggtga ccgtgccgag cagcagcctg      600

ggcacccaga cctatatttg caacgtgaac cataaaccga gcaacaccaa agtggataaa      660

cgcgtggaac cgaaaagctg cgataagacc cacacctgcc ccccctgccc cgcccccgag      720

ctggccggcg cccccagcgt gttcctg                                          747


<210> 377
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 377
gatgtggtga tgacccagag cccgctgagc ctgccggtga ccccgggcgc gccggcgagc       60

attagctgcc gcagcagcca gagcattgtg catagcaacg gcaacaccta tctggaatgg      120

tatctgcaga aaccgggcca gagcccgaaa ctgctgattt ataaagtgag caaccgcttt      180

agcggcgtgc cggatcgctt tagcggcagc ggcagcggca ccgattttac cctgcgcatt      240

agccgcgtgg aagcggaaga tgtgggcatt tattattgct ttcagggcag ccatgtgccg      300

ccgacctttg gcccgggcac caaactggaa attaaacgca ccgtggcggc gccgagcgtg      360

tttatttttc cgccgagcga tgaacagctg aaaagcggca ccgcgagcgt ggtgtgcctg      420

ctgaacaact tttatccgcg cgaagcgaaa gtgcagtgga aagtggataa cgcgctgcag      480

agcggcaaca gccaggaaag cgtgaccgaa caggatagca aagatagcac ctatagcctg      540

agcagcaccc tgaccctgag caaagcggat tatgaaaaac ataaagtgta tgcgtgcgaa      600

gtgacccatc agggcctgag cagcccggtg accaaaagct ttaaccgcgg cgaatgc         657


<210> 378
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (682)..(714)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (700)..(714)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 378
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcca tatttttagc aactattgga ttcagtgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggcgaa attctgccgg gcagcggcca taccgaatat      180

accgaaaact ttaaagatcg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgctatttt      300

tttggcagca gcccgaactg gtattttgat gtgtggggcc agggcaccct ggtgaccgtg      360

agcagcgcga gcaccaaagg cccgagcgtg tttccgctgg cgccgtgcag ccgcagcacc      420

agcgaaagca ccgcggcgct gggctgcctg gtgaaagatt attttccgga accggtgacc      480

gtgagctgga acagcggcgc gctgaccagc ggcgtgcata cctttccggc ggtgctgcag      540

agcagcggcc tgtatagcct gagcagcgtg gtgaccgtgc cgagcagcaa ctttggcacc      600

cagacctata cctgcaacgt ggatcataaa ccgagcaaca ccaaagtgga taaaaccgtg      660

gaacgcaaat gctgcgtgga atgccccccc tgccccgccc cccccgtggc cggc            714


<210> 379
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 379
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcg gcgcgagcga aaacatttat ggcgcgctga actggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatggc gcgaccaacc tggcggatgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagaac gtgctgaaca ccccgctgac ctttggccag      300

ggcaccaaag tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210> 380
<211> 738
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (676)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (685)..(687)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (688)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (706)..(738)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(738)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 380
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc agctatgtga ttcattgggt gcgccagcgc      120

ccgggccagg gcctggcgtg gatgggctat attaacccgt ataacgatgg caccaaatat      180

aacgaacgct ttaaaggcaa agtgaccatt accagcgatc gcagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt atctgtgcgg ccgcgaaggc      300

attcgctatt atggcctgct gggcgattat tggggccagg gcaccctggt gaccgtgagc      360

agcgcgagca ccaaaggccc gagcgtgttt ccgctggcgc cgagcagcaa aagcaccagc      420

ggcggcaccg cggcgctggg ctgcctggtg aaagattatt ttccggaacc ggtgaccgtg      480

agctggaaca gcggcgcgct gaccagcggc gtgcatacct ttccggcggt gctgcagagc      540

agcggcctgt atagcctgag cagcgtggtg accgtgccga gcagcagcct gggcacccag      600

acctatattt gcaacgtgaa ccataaaccg agcaacacca aagtggataa aaaagtggaa      660

ccgaaaagct gcgataagac ccacacctgc cccccctgcc ccgcccccga gctggccggc      720

gcccccagcg tgttcctg                                                    738


<210> 381
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 381
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcg gcaccagcga agatattatt aactatctga actggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatcat accagccgcc tgcagagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcag ggctataccc tgccgtatac ctttggccag      300

ggcaccaaag tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210> 382
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (667)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (682)..(683)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (694)..(726)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(726)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 382
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg tgagcggcct gagcctgacc agcaacagcg tgaactggat tcgccaggcg      120

ccgggcaaag gcctggaatg ggtgggcctg atttggagca acggcgatac cgattataac      180

agcgcgatta aaagccgctt taccattagc cgcgatacca gcaaaagcac cgtgtatctg      240

cagatgaaca gcctgcgcgc ggaagatacc gcggtgtatt attgcgcgcg cgaatattat      300

ggctattttg attattgggg ccagggcacc ctggtgaccg tgagcagcgc gagcaccaaa      360

ggcccgagcg tgtttccgct ggcgccgtgc agccgcagca ccagcgaaag caccgcggcg      420

ctgggctgcc tggtgaaaga ttattttccg gaaccggtga ccgtgagctg gaacagcggc      480

gcgctgacca gcggcgtgca tacctttccg gcggtgctgc agagcagcgg cctgtatagc      540

ctgagcagcg tggtgaccgt gccgagcagc agcctgggca ccaaaaccta tacctgcaac      600

gtggatcata aaccgagcaa caccaaagtg gataaacgcg tggaaagcaa atatgagagc      660

aagtacggcc ccccctgccc cccctgcccc gcccccgagt tcctgggcgg ccccagcgtg      720

ttcctg                                                                 726


<210> 383
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 383
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc tggcgagcga aggcattagc agctatctgg cgtggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatggc gcgaacagcc tgcagaccgg cgtgccgagc      180

cgctttagcg gcagcggcag cgcgaccgat tataccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcag agctataaat ttccgaacac ctttggccag      300

ggcaccaaag tggaagtgaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210> 384
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (673)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (688)..(689)
<223> /replace="ag"

<220>
<221> misc_feature
<222> (700)..(732)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(732)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 384
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc aactatggcc tgagctgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggctgg attagcgcga acaacggcga taccaactat      180

ggccaggaat ttcagggccg cgtgaccatg accaccgata ccagcaccag caccgcgtat      240

atggaactgc gcagcctgcg cagcgatgat accgcggtgt attattgcgc gcgcgatagc      300

agcagcagct gggcgcgctg gttttttgat ctgtggggcc gcggcaccct ggtgaccgtg      360

agcagcgcga gcaccaaagg cccgagcgtg tttccgctgg cgccgtgcag ccgcagcacc      420

agcgaaagca ccgcggcgct gggctgcctg gtgaaagatt attttccgga accggtgacc      480

gtgagctgga acagcggcgc gctgaccagc ggcgtgcata cctttccggc ggtgctgcag      540

agcagcggcc tgtatagcct gagcagcgtg gtgaccgtgc cgagcagcag cctgggcacc      600

aaaacctata cctgcaacgt ggatcataaa ccgagcaaca ccaaagtgga taaacgcgtg      660

gagagcaagt acggcccccc ctgccccccc tgccccgccc ccgagttcct gggcggcccc      720

agcgtgttcc tg                                                          732


<210> 385
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 385
agctatgtgc tgacccagcc gccgagcgtg agcgtggcgc cgggcaaaac cgcgcgcatt       60

acctgcggcg gcaacattat tggcagcaaa ctggtgcatt ggtatcagca gaaaccgggc      120

caggcgccgg tgctggtgat ttatgatgat ggcgatcgcc cgagcggcat tccggaacgc      180

tttagcggca gcaacagcgg caacaccgcg accctgacca ttagccgcgt ggaagcgggc      240

gatgaagcgg attattattg ccaggtgtgg gataccggca gcgatccggt ggtgtttggc      300

ggcggcacca aactgaccgt gctgggccag ccgaaagcgg cgccgagcgt gaccctgttt      360

ccgccgagca gcgaagaact gcaggcgaac aaagcgaccc tggtgtgcct gattagcgat      420

ttttatccgg gcgcggtgac cgtggcgtgg aaagcggata gcagcccggt gaaagcgggc      480

gtggaaacca ccaccccgag caaacagagc aacaacaaat atgcggcgag cagctatctg      540

agcctgaccc cggaacagtg gaaaagccat cgcagctata gctgccaggt gacccatgaa      600

ggcagcaccg tggaaaaaac cgtggcgccg accgaatgca gc                         642


<210> 386
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (679)..(711)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (697)..(711)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 386
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc ggctatatta tgaactgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggcctg attaacccgt ataacggcgg caccgattat      180

aacccgcagt ttcaggatcg cgtgaccatt accgcggata aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgatggc      300

tatgatgatg gcccgtatac cctggaaacc tggggccagg gcaccctggt gaccgtgagc      360

agcgcgagca ccaaaggccc gagcgtgttt ccgctggcgc cgagcagcaa aagcaccagc      420

ggcggcaccg cggcgctggg ctgcctggtg aaagattatt ttccggaacc ggtgaccgtg      480

agctggaaca gcggcgcgct gaccagcggc gtgcatacct ttccggcggt gctgcagagc      540

agcggcctgt atagcctgag cagcgtggtg accgtgccga gcagcaactt tggcacccag      600

acctatacct gcaacgtgga tcataaaccg agcaacacca aagtggataa aaccgtggaa      660

cgcaaaagct gcgtggaatg ccccccctgc cccgcccccc ccgtggccgg c               711


<210> 387
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 387
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc aggcgagcga agatatttat agctttgtgg cgtggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttataac gcgcagaccg aagcgcaggg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcat cattatgata gcccgctgac ctttggcggc      300

ggcaccaaag tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210> 388
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (646)..(708)
<223> /note="This region may be absent in its entirety"

<220>
<221> variation
<222> (655)..(657)
<223> /replace="ctg"

<220>
<221> misc_feature
<222> (658)..(708)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (676)..(708)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (1)..(708)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 388
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg tgagcggcta tagcattacc agcggctata gctggaactg gattcgccag      120

gcgccgggca aaggcctgga atgggtggcg agcattacct atgatggcag caccaactat      180

gcggatagcg tgaaaggccg ctttaccatt agccgcgatg atagcaaaaa caccttttat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcggcagc      300

cattattttg gccattggca ttttgcggtg tggggccagg gcaccctggt gaccgtgagc      360

agcggcccga gcgtgtttcc gctggcgccg agcagcaaaa gcaccagcgg cggcaccgcg      420

gcgctgggct gcctggtgaa agattatttt ccggaaccgg tgaccgtgag ctggaacagc      480

ggcgcgctga ccagcggcgt gcataccttt ccggcggtgc tgcagagcag cggcctgtat      540

agcctgagca gcgtggtgac cgtgccgagc agcagcctgg gcacccagac ctatatttgc      600

aacgtgaacc ataaaccgag caacaccaaa gtggataaaa aagcgaagac ccacacctgc      660

cccccctgcc ccgcccccga gctggccggc gcccccagcg tgttcctg                   708


<210> 389
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 389
gatattcagc tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcca gagcgtggat tatgatggcg atagctatat gaactggtat      120

cagcagaaac cgggcaaagc gccgaaactg ctgatttatg cggcgagcta tctggaaagc      180

ggcgtgccga gccgctttag cggcagcggc agcggcaccg attttaccct gaccattagc      240

agcctgcagc cggaagattt tgcgacctat tattgccagc agagccatga agatccgtat      300

acctttggcc agggcaccaa agtggaaatt aaacgcaccg tggcggcgcc gagcgtgttt      360

atttttccgc cgagcgatga acagctgaaa agcggcaccg cgagcgtggt gtgcctgctg      420

aacaactttt atccgcgcga agcgaaagtg cagtggaaag tggataacgc gctgcagagc      480

ggcaacagcc aggaaagcgt gaccgaacag gatagcaaag atagcaccta tagcctgagc      540

agcaccctga ccctgagcaa agcggattat gaaaaacata aagtgtatgc gtgcgaagtg      600

acccatcagg gcctgagcag cccggtgacc aaaagcttta accgc                      645


<210> 390
<211> 693
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (661)..(693)
<223> /note="This region may be absent in its entirety"

<220>
<221> misc_feature
<222> (679)..(693)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 390
cagatgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttcgc acctatggca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa caaacattat      180

gcggatagcg tgaaaggccg ctttaccatt acccgcgata acagcaaaaa caccctgaac      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgcgccg      300

cagtgggaac tggtgcatga agcgtttgat atttggggcc agggcaccat ggtgaccgtg      360

agcagcgcga gcaccaaagg cccgagcgtg tttccgctgg cgccgtgcag ccgcagcacc      420

agcgaaagca ccgcggcgct gggctgcctg gtgaaagatt attttccgga accggtgacc      480

gtgagctgga acagcggcgc gctgaccagc ggcgtgcata cctttccggc ggtgctgcag      540

agcagcggcc tgtatagcct gagcagcgtg gtgaccgtgc cgagcagcaa ctttggcacc      600

cagacctata cctgcaacgt ggatcataaa ccgagcaaca ccaaagtgga taaaaccgtg      660

tgccccccct gccccgcccc ccccgtggcc ggc                                   693


<210> 391
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 391
agctatgtgc tgacccagcc gccgagcgtg agcgtggcgc cgggccagac cgcgcgcatt       60

acctgcggcg gcaacaacct gggcagcaaa agcgtgcatt ggtatcagca gaaaccgggc      120

caggcgccgg tgctggtggt gtatgatgat agcgatcgcc cgagctggat tccggaacgc      180

tttagcggca gcaacagcgg caacaccgcg accctgacca ttagccgcgg cgaagcgggc      240

gatgaagcgg attattattg ccaggtgtgg gatagcagca gcgatcatgt ggtgtttggc      300

ggcggcacca aactgaccgt gctgggccag ccgaaagcgg cgccgagcgt gaccctgttt      360

ccgccgagca gcgaagaact gcaggcgaac aaagcgaccc tggtgtgcct gattagcgat      420

ttttatccgg gcgcggtgac cgtggcgtgg aaagcggata gcagcccggt gaaagcgggc      480

gtggaaacca ccaccccgag caaacagagc aacaacaaat atgcggcgag cagctatctg      540

agcctgaccc cggaacagtg gaaaagccat cgcagctata gctgccaggt gacccatgaa      600

ggcagcaccg tggaaaaaac cgtggcgccg accgaatgca gc                         642


<210> 392
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 392
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 393
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 393
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210> 394
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 394
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 395
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 395
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210> 396
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 396
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210> 397
<211> 203
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 397
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        195                 200             


<210> 398
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 398
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210> 399
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 399
Glu Lys His Lys Val Tyr 
1               5       


<210> 400
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 400
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly 
            


<210> 401

<400> 401

000     


Ala Gly Gly 
            


<210> 402

<400> 402

000       


<210> 403
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 403
Glu Asp Ile Ala Thr Tyr Tyr 
1               5           


<210> 404

<400> 404

000


<210> 405


<400> 405

000


<210> 406

<400> 406

000
    


<210> 407


<400> 407

000 
            


<210> 408

<400> 408

000
        


<210> 409
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 409
Glu Asp Val Gly Ile Val Tyr Tyr
1               5   


<210> 410


<400> 410

000

<210> 411
<211> 1725
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 411
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaag                     1725


<210> 412
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 412
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210> 413
<211> 865
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 413
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tcccctgcat gcgaagatct tcgaacaagg ctgtggggga ctgagggcag      480

gctgtaacag gcttgggggc cagggcttat acgtgcctgg gactcccaaa gtattactgt      540

tccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca cttagtttag      600

gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg ctgggcaagc      660

tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag ctcatctgct      720

ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct      780

atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca gcacagacag      840

acactcagga gccagccagc gtcga                                            865


<210> 414
<211> 251
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 414
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210> 415
<211> 212
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 415
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210> 416
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 416
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210> 417
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 417
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc ccagggctca       60

ctgtgggtct ctctgttcac ag                                                82


<210> 418
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 418
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210> 419
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 419
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210> 420
<211> 143
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 420
gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caa                                              143


<210> 421
<211> 110
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 421
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                 110


<210> 422
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 422
atgtatagga tgcaactgct cctcctgatt gctctgagcc tggctcttgt gaccaactct       60


<210> 423
<211> 460
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 423
gggctggaag ctacctttga catcatttcc tctgcgaatg catgtataat ttctacagaa       60

cctattagaa aggatcaccc agcctctgct tttgtacaac tttcccttaa aaaactgcca      120

attccactgc tgtttggccc aatagtgaga actttttcct gctgcctctt ggtgcttttg      180

cctatggccc ctattctgcc tgctgaagac actcttgcca gcatggactt aaacccctcc      240

agctctgaca atcctctttc tcttttgttt tacatgaagg gtctggcagc caaagcaatc      300

actcaaagtt caaaccttat cattttttgc tttgttcctc ttggccttgg ttttgtacat      360

cagctttgaa aataccatcc cagggttaat gctggggtta atttataact aagagtgctc      420

tagttttgca atacaggaca tgctataaaa atggaaagat                            460


<210> 424
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 424
agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg ggatgttgaa       60

gagaatcctg ggcct                                                        75


<210> 425
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 425
agaaagagaa ga                                                           12


<210> 426
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 426
agaaagagaa gaggctctgg a                                                 21


<210> 427
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 427
ggctctgga                                                                9


<210> 428
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 428
gaaggcagag gctccctgct gacatgtggg gatgttgaag agaatcctgg gcct             54


<210> 429
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (5)..(7)
<223> /note="This region may be absent in its entirety"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 429
Arg Lys Arg Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210> 430
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 430
Cys Pro Pro Cys Ala 
1               5   


<210> 431
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 431
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly 
            


<210> 432
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 432
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly 
            


<210> 433
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 433
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210> 434
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 434
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210> 435
<211> 4196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 435
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgcta     1740

gcgggcactt tgcactggaa cttacaacac ccgagcaagg acgcgactct ccaccatgta     1800

ccggatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca atagcgaagt     1860

ccagctgctg gaatctggcg gcggacttgt tcaacctggc ggctctctga gactgagctg     1920

tgccgcttcc ggcttcacct tcagccacta tatcatgatg tgggtccgac aggcccctgg     1980

caaaggcctt gaatgggtgt ccggcatcta tagcagcggc ggcatcacag tgtacgccga     2040

ctctgtgaag ggcagattca ccatcagccg ggacaacagc aagaacaccc tgtacctgca     2100

gatgaacagc ctgagagccg aggacaccgc cgtgtactac tgcgcctata gaagaatcgg     2160

cgtgcccaga cgggacgagt tcgatatttg gggccagggc accatggtca ccgtgtctag     2220

cgcctctaca aagggcccta gcgtgttccc tctggctcct agcagcaaga gcacaagcgg     2280

aggaacagcc gctctgggct gtctggtcaa ggactacttt cccgagcctg tgaccgtgtc     2340

ctggaatagc ggagcactga caagcggcgt gcacaccttt ccagctgtgc tgcaaagcag     2400

cggcctgtac tctctgagca gcgtggtcac agtgccaagc tctagcctgg gcacccagac     2460

ctacatctgc aatgtgaacc acaagcctag caacaccaag gtggacaaga gagtggaacc     2520

caagagctgc gacaagaccc acacctgtcc tccatgtcct gctccagaac tgctcggcgg     2580

accttccgtg ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc     2640

tgaagtgacc tgcgtggtgg tggatgtgtc ccacgaggat cccgaagtga agttcaattg     2700

gtacgtggac ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa     2760

cagcacctac agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa     2820

agagtacaag tgcaaggtgt ccaacaaggc cctgcctgct cctatcgaga aaaccatcag     2880

caaggccaag ggccagccta gggaacccca ggtttacaca ctgcctccaa gccgggaaga     2940

gatgaccaag aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat     3000

cgccgtggaa tgggagagca atggccagcc agagaacaac tacaagacaa cccctcctgt     3060

gctggacagc gacggctcat tcttcctgta cagcaagctg acagtggaca agtccagatg     3120

gcagcagggc aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac     3180

ccagaagagt ctgagcctgt ctccaggcct gcggaagaga agggctcctg tgaagcagac     3240

cctgaacttc gacctgctga aactggccgg cgacgtggaa agcaaccccg gacctatgta     3300

tagaatgcag ctcctcctgc tgatcgcact gagcctggct ctcgtgacca acagcgacat     3360

ccagatgaca cagagcccca gcacactgtc tgccagcgtg ggagacagag tgaccatcac     3420

ctgtagagcc agccagtcca tctcctcttg gctggcctgg tatcagcaaa agcctggcaa     3480

ggcccctaag ctgctgatct acaaggcctc cacactggaa agcggggtgc cctccagatt     3540

ttctggcagc ggatctggca ccgagttcac cctgaccatc agtagcctgc agcctgacga     3600

cttcgccacc tactactgcc agcagtacaa tacctactgg accttcggcc agggaacaaa     3660

ggtggaaatc aagcggactg tggccgctcc aagcgtgttc atctttccac ctagcgacga     3720

gcagctgaag tccggcacag cctctgttgt gtgcctgctg aacaacttct accccagaga     3780

agccaaggtg cagtggaaag tggacaatgc cctgcagagc ggcaactccc aagagagcgt     3840

gacagagcag gactccaagg attccaccta cagcctgtct agcaccctga cactgagcaa     3900

ggccgactac gagaagcaca aagtgtatgc ctgcgaagtg acccaccagg gccttagctc     3960

tccagtgacc aagagcttca accggggcga gtgttgataa agcggccgcg gtacctctag     4020

agtcgacccg ggcggcctcg aggacggggt gaactacgcc tgaggatccg atctttttcc     4080

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     4140

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcg         4196


<210> 436
<211> 4106
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 436
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccgccacca     1740

tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc accaattctg     1800

aggtccagct gcttgagagt ggtggtggac tggttcagcc tggtggcagc ctgagactgt     1860

cttgtgctgc ctctggcttc accttcagcc actatatcat gatgtgggtc agacaggccc     1920

ctggcaaagg cctggaatgg gtgtcaggca tctacagcag tggtggcatc acagtgtatg     1980

ctgactctgt gaagggcaga ttcaccatca gcagagacaa cagcaagaac accctgtacc     2040

tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc tatagaagaa     2100

ttggggtgcc cagaagggat gagtttgaca tctggggcca gggcaccatg gttacagtgt     2160

cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc aagagcacca     2220

gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag cctgtgactg     2280

tgtcctggaa ctctggggct ctgacctctg gggtgcacac ctttccagct gtgctgcagt     2340

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc ctgggcacac     2400

agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagagagtgg     2460

aacccaagag ctgtgacaag acccacacct gtcctccatg tcctgctcca gaactgcttg     2520

gaggcccttc tgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa     2580

cccctgaagt gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca     2640

attggtatgt ggatggggtt gaagtgcaca atgccaagac caagcctaga gaggaacagt     2700

acaacagcac ctacagagtg gtttctgtgc tgacagtgct gcaccaggac tggctgaatg     2760

gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gagaaaacca     2820

tctccaaggc caagggccag ccaagagaac cccaggttta caccctgcca cctagcagag     2880

aagagatgac caagaaccag gtgtccctga cctgcctggt taagggcttc tacccctctg     2940

acattgctgt ggaatgggag agcaatggcc agcctgaaaa caactacaag acaacccctc     3000

ctgtgctgga ctctgatggc tcattcttcc tgtacagcaa gctgactgtg gacaagtcca     3060

gatggcagca gggaaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact     3120

acacccagaa aagtctgtct ctgtcccctg gcagaaagag aagaggatca ggggccccag     3180

tgaagcagac cctgaacttt gatctgctga agctggctgg ggatgttgag agcaaccctg     3240

gacctatgta taggatgcaa ctgctcctcc tgattgctct gagcctggct cttgtgacca     3300

actctgacat ccagatgaca cagagcccct ccacactgtc tgcatctgtg ggagacagag     3360

tgaccatcac ctgtagagcc agccagtcta tctcttcctg gctggcctgg tatcagcaaa     3420

agcctggcaa ggcccctaag ctgctgatct acaaggccag cacacttgag tcaggggtgc     3480

cctccagatt ttctggctct ggatctggca cagagttcac cctgaccatc agctccctgc     3540

agccagatga ctttgccacc tactactgcc agcagtacaa tacctactgg acctttggcc     3600

agggaacaaa ggtggaaatc aagagaacag tggctgcccc atctgtgttc atcttcccac     3660

catctgatga acagctgaag tctggcactg cctctgttgt gtgcctgctg aacaactttt     3720

accctagaga agccaaggtg cagtggaaag tggataatgc cctgcagtct ggcaatagcc     3780

aagaatctgt gacagagcag gactccaagg attccaccta cagcctgagc agcaccctga     3840

cactgagcaa ggctgactat gagaagcaca aagtgtatgc ctgtgaagtg acacaccagg     3900

gactgagcag cccagtgacc aagagcttca acaggggaga gtgctgataa ctcgaggacg     3960

gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat ggggacatca     4020

tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag     4080

tgtgttggaa ttttttgtgt ctctca                                          4106


<210> 437
<211> 4092
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 437
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccgccacca     1740

tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc accaattctg     1800

aggtccagct gcttgagagt ggtggtggac tggttcagcc tggtggcagc ctgagactgt     1860

cttgtgctgc ctctggcttc accttcagcc actatatcat gatgtgggtc agacaggccc     1920

ctggcaaagg cctggaatgg gtgtcaggca tctacagcag tggtggcatc acagtgtatg     1980

ctgactctgt gaagggcaga ttcaccatca gcagagacaa cagcaagaac accctgtacc     2040

tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc tatagaagaa     2100

ttggggtgcc cagaagggat gagtttgaca tctggggcca gggcaccatg gttacagtgt     2160

cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc aagagcacca     2220

gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag cctgtgactg     2280

tgtcctggaa ctctggggct ctgacttctg gggtgcacac ctttccagct gtgctgcagt     2340

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc ctgggcacac     2400

agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagagagtgg     2460

aacccaagag ctgtgacaag acccacacct gtcctccatg tcctgctcca gaactgcttg     2520

gaggcccttc tgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa     2580

cccctgaagt gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca     2640

attggtatgt ggatggggtt gaagtgcaca atgccaagac caagcctaga gaggaacagt     2700

acaacagcac ctacagagtg gtttctgtgc tgacagtgct gcaccaggac tggctgaatg     2760

gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gagaaaacca     2820

tctccaaggc caagggccag ccaagagaac cccaggttta caccctgcca cctagcagag     2880

aagagatgac caagaaccag gtgtccctga cctgcctggt taagggcttc tacccctctg     2940

acattgctgt ggaatgggag agcaatggcc agcctgaaaa caactacaag acaacccctc     3000

ctgtgctgga ctctgatggc tcattcttcc tgtacagcaa gctgactgtg gacaagtcca     3060

gatggcagca gggaaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact     3120

acacccagaa aagtctgtct ctgtcccctg gcagaaagag aagaggctct ggagaaggca     3180

gaggctccct gctgacatgt ggggatgttg aagagaatcc tgggcctatg tataggatgc     3240

aactgctcct cctgattgct ctgagcctgg ctcttgtgac caactctgac atccagatga     3300

cacagagccc ctccacactg tctgcatctg tgggagacag agtgaccatc acctgtagag     3360

ccagccagtc tatctctagc tggctggcct ggtatcagca aaagcctggc aaggccccta     3420

agctgctgat ctacaaggcc agcacacttg agtcaggggt gccctccaga ttttctggct     3480

ctggatctgg cacagagttc accctgacca tcagctccct gcagccagat gactttgcca     3540

cctactactg ccagcagtac aatacctact ggacctttgg ccagggaaca aaggtggaaa     3600

tcaagagaac agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga     3660

agtctggcac tgcctctgtt gtgtgcctgc tgaacaactt ttaccccaga gaagccaagg     3720

tgcagtggaa agtggataat gccctgcagt ctggcaatag ccaagaatct gtgacagagc     3780

aggactccaa ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact     3840

atgagaagca caaagtgtat gcctgtgaag tgacacacca gggactgagc agcccagtga     3900

ccaagagctt caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag     3960

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4020

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4080

gtctctcact cg                                                         4092


<210> 438
<211> 3397
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 438
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagagacag ctttattgcg gtagtttatc      720

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca      780

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag      840

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      900

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt      960

acagctctta aggctagagt acttaatacg actcactata ggctagcctc gagaattcac     1020

gcgtgccgcc accatgtaca gaatgcagct gctgctgctc attgccctgt ctctggccct     1080

ggtcaccaat tctgaggtcc agctgcttga gagtggtggt ggactggttc agcctggtgg     1140

cagcctgaga ctgtcttgtg ctgcctctgg cttcaccttc agccactata tcatgatgtg     1200

ggtcagacag gcccctggca aaggcctgga atgggtgtca ggcatctaca gcagtggtgg     1260

catcacagtg tatgctgact ctgtgaaggg cagattcacc atcagcagag acaacagcaa     1320

gaacaccctg tacctgcaga tgaactccct gagagctgag gacacagcag tgtactactg     1380

tgcctataga agaattgggg tgcccagaag ggatgagttt gacatctggg gccagggcac     1440

catggttaca gtgtcctctg ccagcacaaa gggcccctct gtttttccac tggctcccag     1500

cagcaagagc accagtggtg gaacagctgc cctgggctgt ctggtcaagg attacttccc     1560

tgagcctgtg actgtgtcct ggaactctgg ggctctgact tctggggtgc acacctttcc     1620

agctgtgctg cagtcctctg gcctgtactc tctgtcctct gtggtcacag tgcctagctc     1680

tagcctgggc acacagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt     1740

ggacaagaga gtggaaccca agagctgtga caagacccac acctgtcctc catgtcctgc     1800

tccagaactg cttggaggcc cttctgtgtt cctgtttcct ccaaagccta aggacaccct     1860

gatgatcagc agaacccctg aagtgacctg tgtggtggtt gatgtgtccc atgaggaccc     1920

agaagtgaag ttcaattggt atgtggatgg ggttgaagtg cacaatgcca agaccaagcc     1980

tagagaggaa cagtacaaca gcacctacag agtggtttct gtgctgacag tgctgcacca     2040

ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc     2100

tattgagaaa accatctcca aggccaaggg ccagccaaga gaaccccagg tttacaccct     2160

gccacctagc agagaagaga tgaccaagaa ccaggtgtcc ctgacctgcc tggttaaggg     2220

cttctacccc tctgacattg ctgtggaatg ggagagcaat ggccagcctg aaaacaacta     2280

caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtaca gcaagctgac     2340

tgtggacaag tccagatggc agcagggaaa tgtgttcagc tgctctgtga tgcatgaggc     2400

cctgcacaac cactacaccc agaaaagtct gtctctgtcc cctggcagaa agagaagagg     2460

ctctggagaa ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc     2520

tatgtatagg atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc     2580

tgacatccag atgacacaga gcccctccac actgtctgca tctgtgggag acagagtgac     2640

catcacctgt agagccagcc agtctatctc tagctggctg gcctggtatc agcaaaagcc     2700

tggcaaggcc cctaagctgc tgatctacaa ggccagcaca cttgagtcag gggtgccctc     2760

cagattttct ggctctggat ctggcacaga gttcaccctg accatcagct ccctgcagcc     2820

agatgacttt gccacctact actgccagca gtacaatacc tactggacct ttggccaggg     2880

aacaaaggtg gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc     2940

tgatgaacag ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttttaccc     3000

cagagaagcc aaggtgcagt ggaaagtgga taatgccctg cagtctggca atagccaaga     3060

atctgtgaca gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact     3120

gagcaaggct gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact     3180

gagcagccca gtgaccaaga gcttcaacag gggagagtgc tgataagtcg acccgggcgg     3240

cctcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     3300

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3360

cattgcaata gtgtgttgga attttttgtg tctctca                              3397


<210> 439
<211> 3227
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 439
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggcttg      780

tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac      840

tttgcctttc tctccacagg ttcgaattcg ccgccaccat gtacagaatg cagctgctgc      900

tgctcattgc cctgtctctg gccctggtca ccaattctga ggtccagctg cttgagagtg      960

gtggtggact ggttcagcct ggtggcagcc tgagactgtc ttgtgctgcc tctggcttca     1020

ccttcagcca ctatatcatg atgtgggtca gacaggcccc tggcaaaggc ctggaatggg     1080

tgtcaggcat ctacagcagt ggtggcatca cagtgtatgc tgactctgtg aagggcagat     1140

tcaccatcag cagagacaac agcaagaaca ccctgtacct gcagatgaac tccctgagag     1200

ctgaggacac agcagtgtac tactgtgcct atagaagaat tggggtgccc agaagggatg     1260

agtttgacat ctggggccag ggcaccatgg ttacagtgtc ctctgccagc acaaagggcc     1320

cctctgtttt tccactggct cccagcagca agagcaccag tggtggaaca gctgccctgg     1380

gctgtctggt caaggattac ttccctgagc ctgtgactgt gtcctggaac tctggggctc     1440

tgacttctgg ggtgcacacc tttccagctg tgctgcagtc ctctggcctg tactctctgt     1500

cctctgtggt cacagtgcct agctctagcc tgggcacaca gacctacatc tgcaatgtga     1560

accacaagcc tagcaacacc aaggtggaca agagagtgga acccaagagc tgtgacaaga     1620

cccacacctg tcctccatgt cctgctccag aactgcttgg aggcccttct gtgttcctgt     1680

ttcctccaaa gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg     1740

tggttgatgt gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggggttg     1800

aagtgcacaa tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg     1860

tttctgtgct gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg     1920

tgtccaacaa ggccctgcct gctcctattg agaaaaccat ctccaaggcc aagggccagc     1980

caagagaacc ccaggtttac accctgccac ctagcagaga agagatgacc aagaaccagg     2040

tgtccctgac ctgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga     2100

gcaatggcca gcctgaaaac aactacaaga caacccctcc tgtgctggac tctgatggct     2160

cattcttcct gtacagcaag ctgactgtgg acaagtccag atggcagcag ggaaatgtgt     2220

tcagctgctc tgtgatgcat gaggccctgc acaaccacta cacccagaaa agtctgtctc     2280

tgtcccctgg cagaaagaga agaggctctg gagaaggcag aggctccctg ctgacatgtg     2340

gggatgttga agagaatcct gggcctatgt ataggatgca actgctcctc ctgattgctc     2400

tgagcctggc tcttgtgacc aactctgaca tccagatgac acagagcccc tccacactgt     2460

ctgcatctgt gggagacaga gtgaccatca cctgtagagc cagccagtct atctctagct     2520

ggctggcctg gtatcagcaa aagcctggca aggcccctaa gctgctgatc tacaaggcca     2580

gcacacttga gtcaggggtg ccctccagat tttctggctc tggatctggc acagagttca     2640

ccctgaccat cagctccctg cagccagatg actttgccac ctactactgc cagcagtaca     2700

atacctactg gacctttggc cagggaacaa aggtggaaat caagagaaca gtggctgccc     2760

catctgtgtt catcttccca ccatctgatg aacagctgaa gtctggcact gcctctgttg     2820

tgtgcctgct gaacaacttt taccccagag aagccaaggt gcagtggaaa gtggataatg     2880

ccctgcagtc tggcaatagc caagaatctg tgacagagca ggactccaag gattccacct     2940

acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac aaagtgtatg     3000

cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc aacaggggag     3060

agtgctgata actcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg     3120

ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga     3180

aatttatttt cattgcaata gtgtgttgga attttttgtg tctctca                   3227


<210> 440
<211> 3472
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 440
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     1020

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1080

atccactttg cctttctctc cacaggttga attcgccgcc accatgtaca gaatgcagct     1140

gctgctgctc attgccctgt ctctggccct ggtcaccaat tctgaggtcc agctgcttga     1200

gagtggtggt ggactggttc agcctggtgg cagcctgaga ctgtcttgtg ctgcctctgg     1260

cttcaccttc agccactata tcatgatgtg ggtcagacag gcccctggca aaggcctgga     1320

atgggtgtca ggcatctaca gcagtggtgg catcacagtg tatgctgact ctgtgaaggg     1380

cagattcacc atcagcagag acaacagcaa gaacaccctg tacctgcaga tgaactccct     1440

gagagctgag gacacagcag tgtactactg tgcctataga agaattgggg tgcccagaag     1500

ggatgagttt gacatctggg gccagggcac catggttaca gtgtcctctg ccagcacaaa     1560

gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg gaacagctgc     1620

cctgggctgt ctggtcaagg attacttccc tgagcctgtg actgtgtcct ggaactctgg     1680

ggctctgact tctggggtgc acacctttcc agctgtgctg cagtcctctg gcctgtactc     1740

tctgtcctct gtggtcacag tgcctagctc tagcctgggc acacagacct acatctgcaa     1800

tgtgaaccac aagcctagca acaccaaggt ggacaagaga gtggaaccca agagctgtga     1860

caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc cttctgtgtt     1920

cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg     1980

tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg     2040

ggttgaagtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag     2100

agtggtttct gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg     2160

caaggtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca aggccaaggg     2220

ccagccaaga gaaccccagg tttacaccct gccacctagc agagaagaga tgaccaagaa     2280

ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg     2340

ggagagcaat ggccagcctg aaaacaacta caagacaacc cctcctgtgc tggactctga     2400

tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc agcagggaaa     2460

tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaaaagtct     2520

gtctctgtcc cctggcagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac     2580

atgtggggat gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat     2640

tgctctgagc ctggctcttg tgaccaactc tgacatccag atgacacaga gcccctccac     2700

actgtctgca tctgtgggag acagagtgac catcacctgt agagccagcc agtctatctc     2760

tagctggctg gcctggtatc agcaaaagcc tggcaaggcc cctaagctgc tgatctacaa     2820

ggccagcaca cttgagtcag gggtgccctc cagattttct ggctctggat ctggcacaga     2880

gttcaccctg accatcagct ccctgcagcc agatgacttt gccacctact actgccagca     2940

gtacaatacc tactggacct ttggccaggg aacaaaggtg gaaatcaaga gaacagtggc     3000

tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagtctg gcactgcctc     3060

tgttgtgtgc ctgctgaaca acttttaccc cagagaagcc aaggtgcagt ggaaagtgga     3120

taatgccctg cagtctggca atagccaaga atctgtgaca gagcaggact ccaaggattc     3180

cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga agcacaaagt     3240

gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga gcttcaacag     3300

gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg atctttttcc     3360

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     3420

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct ca             3472


<210> 441
<211> 3553
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 441
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt caggtaagta tcaaggttac aagacaggtt     1080

taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag     1140

gcacctattg gtcttactga catccacttt gcctttctct ccacaggttg aattcgccgc     1200

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1260

ttctgaggtc cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag     1320

actgtcttgt gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca     1380

ggcccctggc aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt     1440

gtatgctgac tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct     1500

gtacctgcag atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag     1560

aagaattggg gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac     1620

agtgtcctct gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag     1680

caccagtggt ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt     1740

gactgtgtcc tggaactctg gggctctgac ttctggggtg cacacctttc cagctgtgct     1800

gcagtcctct ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg     1860

cacacagacc tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagag     1920

agtggaaccc aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact     1980

gcttggaggc ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag     2040

cagaacccct gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa     2100

gttcaattgg tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga     2160

acagtacaac agcacctaca gagtggtttc tgtgctgaca gtgctgcacc aggactggct     2220

gaatggcaaa gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa     2280

aaccatctcc aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag     2340

cagagaagag atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc     2400

ctctgacatt gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac     2460

ccctcctgtg ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa     2520

gtccagatgg cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa     2580

ccactacacc cagaaaagtc tgtctctgtc ccctggcaga aagagaagag gctctggaga     2640

aggcagaggc tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag     2700

gatgcaactg ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgacatcca     2760

gatgacacag agcccctcca cactgtctgc atctgtggga gacagagtga ccatcacctg     2820

tagagccagc cagtctatct ctagctggct ggcctggtat cagcaaaagc ctggcaaggc     2880

ccctaagctg ctgatctaca aggccagcac acttgagtca ggggtgccct ccagattttc     2940

tggctctgga tctggcacag agttcaccct gaccatcagc tccctgcagc cagatgactt     3000

tgccacctac tactgccagc agtacaatac ctactggacc tttggccagg gaacaaaggt     3060

ggaaatcaag agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgaaca     3120

gctgaagtct ggcactgcct ctgttgtgtg cctgctgaac aacttttacc ccagagaagc     3180

caaggtgcag tggaaagtgg ataatgccct gcagtctggc aatagccaag aatctgtgac     3240

agagcaggac tccaaggatt ccacctacag cctgagcagc accctgacac tgagcaaggc     3300

tgactatgag aagcacaaag tgtatgcctg tgaagtgaca caccagggac tgagcagccc     3360

agtgaccaag agcttcaaca ggggagagtg ctgataactc gaggacgggg tgaactacgc     3420

ctgaggatcc gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     3480

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     3540

tttgtgtctc tca                                                        3553


<210> 442
<211> 3592
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 442
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     1140

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1200

atccactttg cctttctctc cacaggttga attcgccgcc accatgtaca gaatgcagct     1260

gctgctgctc attgccctgt ctctggccct ggtcaccaat tctgaggtcc agctgcttga     1320

gagtggtggt ggactggttc agcctggtgg cagcctgaga ctgtcttgtg ctgcctctgg     1380

cttcaccttc agccactata tcatgatgtg ggtcagacag gcccctggca aaggcctgga     1440

atgggtgtca ggcatctaca gcagtggtgg catcacagtg tatgctgact ctgtgaaggg     1500

cagattcacc atcagcagag acaacagcaa gaacaccctg tacctgcaga tgaactccct     1560

gagagctgag gacacagcag tgtactactg tgcctataga agaattgggg tgcccagaag     1620

ggatgagttt gacatctggg gccagggcac catggttaca gtgtcctctg ccagcacaaa     1680

gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg gaacagctgc     1740

cctgggctgt ctggtcaagg attacttccc tgagcctgtg actgtgtcct ggaactctgg     1800

ggctctgact tctggggtgc acacctttcc agctgtgctg cagtcctctg gcctgtactc     1860

tctgtcctct gtggtcacag tgcctagctc tagcctgggc acacagacct acatctgcaa     1920

tgtgaaccac aagcctagca acaccaaggt ggacaagaga gtggaaccca agagctgtga     1980

caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc cttctgtgtt     2040

cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg     2100

tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg     2160

ggttgaagtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag     2220

agtggtttct gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg     2280

caaggtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca aggccaaggg     2340

ccagccaaga gaaccccagg tttacaccct gccacctagc agagaagaga tgaccaagaa     2400

ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg     2460

ggagagcaat ggccagcctg aaaacaacta caagacaacc cctcctgtgc tggactctga     2520

tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc agcagggaaa     2580

tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaaaagtct     2640

gtctctgtcc cctggcagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac     2700

atgtggggat gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat     2760

tgctctgagc ctggctcttg tgaccaactc tgacatccag atgacacaga gcccctccac     2820

actgtctgca tctgtgggag acagagtgac catcacctgt agagccagcc agtctatctc     2880

tagctggctg gcctggtatc agcaaaagcc tggcaaggcc cctaagctgc tgatctacaa     2940

ggccagcaca cttgagtcag gggtgccctc cagattttct ggctctggat ctggcacaga     3000

gttcaccctg accatcagct ccctgcagcc agatgacttt gccacctact actgccagca     3060

gtacaatacc tactggacct ttggccaggg aacaaaggtg gaaatcaaga gaacagtggc     3120

tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagtctg gcactgcctc     3180

tgttgtgtgc ctgctgaaca acttttaccc cagagaagcc aaggtgcagt ggaaagtgga     3240

taatgccctg cagtctggca atagccaaga atctgtgaca gagcaggact ccaaggattc     3300

cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga agcacaaagt     3360

gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga gcttcaacag     3420

gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg atctttttcc     3480

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     3540

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct ca             3592


<210> 443
<211> 4083
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 443
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca     1620

atagaaactg ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg     1680

tcttactgac atccactttg cctttctctc cacaggttcg aattcgccgc caccatgtac     1740

agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa ttctgaggtc     1800

cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag actgtcttgt     1860

gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca ggcccctggc     1920

aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt gtatgctgac     1980

tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct gtacctgcag     2040

atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag aagaattggg     2100

gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac agtgtcctct     2160

gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt     2220

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gactgtgtcc     2280

tggaactctg gggctctgac ttctggggtg cacacctttc cagctgtgct gcagtcctct     2340

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacacagacc     2400

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagag agtggaaccc     2460

aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact gcttggaggc     2520

ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct     2580

gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa gttcaattgg     2640

tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga acagtacaac     2700

agcacctaca gagtggtttc tgtgctgaca gtgctgcacc aggactggct gaatggcaaa     2760

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa aaccatctcc     2820

aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag cagagaagag     2880

atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc ctctgacatt     2940

gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac ccctcctgtg     3000

ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa gtccagatgg     3060

cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa ccactacacc     3120

cagaaaagtc tgtctctgtc ccctggcaga aagagaagag gctctggaga aggcagaggc     3180

tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag gatgcaactg     3240

ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgacatcca gatgacacag     3300

agcccctcca cactgtctgc atctgtggga gacagagtga ccatcacctg tagagccagc     3360

cagtctatct ctagctggct ggcctggtat cagcaaaagc ctggcaaggc ccctaagctg     3420

ctgatctaca aggccagcac acttgagtca ggggtgccct ccagattttc tggctctgga     3480

tctggcacag agttcaccct gaccatcagc tccctgcagc cagatgactt tgccacctac     3540

tactgccagc agtacaatac ctactggacc tttggccagg gaacaaaggt ggaaatcaag     3600

agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgaaca gctgaagtct     3660

ggcactgcct ctgttgtgtg cctgctgaac aacttttacc ccagagaagc caaggtgcag     3720

tggaaagtgg ataatgccct gcagtctggc aatagccaag aatctgtgac agagcaggac     3780

tccaaggatt ccacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag     3840

aagcacaaag tgtatgcctg tgaagtgaca caccagggac tgagcagccc agtgaccaag     3900

agcttcaaca ggggagagtg ctgataactc gaggacgggg tgaactacgc ctgaggatcc     3960

gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact     4020

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc     4080

tca                                                                   4083


<210> 444
<211> 1353
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 444
gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg       60

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      180

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      240

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      300

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      360

tctgccagca caaagggccc ctctgttttt ccactggctc ccagcagcaa gagcaccagt      420

ggtggaacag ctgccctggg ctgtctggtc aaggattact tccctgagcc tgtgacagtg      480

tcttggaact caggggctct gacctctggg gtgcacacat ttccagctgt gctgcagtcc      540

tctggcctgt actctctgtc ctctgtggtc acagtgccta gctctagcct gggcacccag      600

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gtgacaagac ccacacctgt cctccatgtc ctgctccaga actgcttgga      720

ggcccttctg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      780

cctgaagtga cctgtgtggt ggttgatgtg tcccatgagg acccagaagt gaagttcaat      840

tggtatgtgg atggggttga agtgcacaat gctaagacca agcctagaga ggaacagtac      900

aacagcacct acagagtggt gtctgtgctg acagtgctgc atcaggactg gctgaatggc      960

aaagagtaca agtgcaaagt gtccaacaag gccctgcctg ctcctattga gaaaaccatc     1020

tccaaggcca agggccagcc aagagaaccc caggtttaca cactgccacc tagcagagat     1080

gagctgacca agaaccaggt gtccctgacc tgcctggtta agggcttcta cccctctgac     1140

attgctgtgg aatgggagag caatggccag cctgagaaca actacaagac aacccctcct     1200

gtgctggact ctgatggctc attcttcctg tacagcaagc tgactgtgga caagtccaga     1260

tggcagcagg ggaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac     1320

acccagaaaa gtctgagtct gagccctggc aag                                  1353


<210> 445
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 445
gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg       60

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      180

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      240

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      300

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      360

tct                                                                    363


<210> 446
<211> 294
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 446
gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt       60

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gacagtgtct      120

tggaactcag gggctctgac ctctggggtg cacacatttc cagctgtgct gcagtcctct      180

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacccagacc      240

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtg            294


<210> 447
<211> 651
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 447
gctccagaac tgcttggagg cccttctgtg ttcctgtttc ctccaaagcc taaggacacc       60

ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg ttgatgtgtc ccatgaggac      120

ccagaagtga agttcaattg gtatgtggat ggggttgaag tgcacaatgc taagaccaag      180

cctagagagg aacagtacaa cagcacctac agagtggtgt ctgtgctgac agtgctgcat      240

caggactggc tgaatggcaa agagtacaag tgcaaagtgt ccaacaaggc cctgcctgct      300

cctattgaga aaaccatctc caaggccaag ggccagccaa gagaacccca ggtttacaca      360

ctgccaccta gcagagatga gctgaccaag aaccaggtgt ccctgacctg cctggttaag      420

ggcttctacc cctctgacat tgctgtggaa tgggagagca atggccagcc tgagaacaac      480

tacaagacaa cccctcctgt gctggactct gatggctcat tcttcctgta cagcaagctg      540

actgtggaca agtccagatg gcagcagggg aatgtgttca gctgctctgt gatgcatgag      600

gccctgcaca accactacac ccagaaaagt ctgagtctga gccctggcaa g               651


<210> 448
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 448
gacatccaga tgacacagag ccctagcagc ctgtctgctt ctgtgggaga cagagtgacc       60

atcacatgca gagccagcca gggaatcaga aactacctgg cctggtatca gcaaaagcct      120

ggcaaggccc ctaagctgct gatctatgca gccagcacac tgcagtcagg ggtgccaagc      180

agattttcag gctctggctc tggcacagac ttcaccctga ccatttctag cctgcagcct      240

gaggatgtgg ccacctacta ctgccagaga tacaacagag ccccatacac ctttggacag      300

ggcacaaagg tggaaatcaa gagaacagtg gctgccccat ctgtgttcat cttcccacca      360

tctgatgaac agctgaagtc tggcactgcc tctgttgtgt gcctgctgaa caacttctac      420

cctagagaag ccaaggtgca gtggaaggtt gacaatgccc tgcagtctgg caatagccaa      480

gaatctgtga cagagcagga ctccaaggat tccacctaca gcctgagcag caccctgaca      540

ctgagcaagg ctgactatga gaagcacaaa gtgtatgcct gtgaagtgac acaccaggga      600

ctgagcagcc cagtgaccaa gagcttcaac aggggagagt gc                         642


<210> 449
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 449
gacatccaga tgacacagag ccctagcagc ctgtctgctt ctgtgggaga cagagtgacc       60

atcacatgca gagccagcca gggaatcaga aactacctgg cctggtatca gcaaaagcct      120

ggcaaggccc ctaagctgct gatctatgca gccagcacac tgcagtcagg ggtgccaagc      180

agattttcag gctctggctc tggcacagac ttcaccctga ccatttctag cctgcagcct      240

gaggatgtgg ccacctacta ctgccagaga tacaacagag ccccatacac ctttggacag      300

ggcacaaagg tggaaatcaa g                                                321


<210> 450
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 450
agaacagttg cagcaccctc agttttcatc ttccccccct cagatgaaca gctgaagtct       60

ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ccagagaagc caaggtgcag      120

tggaaggttg acaatgccct gcagtcaggc aacagccaag aatctgtgac tgaacaggat      180

tccaaggata gcacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag      240

aagcacaaag tgtatgcctg tgaagtgacc caccagggac tgagcagccc agtgaccaag      300

agcttcaaca ggggagagtg ctga                                             324


<210> 451
<211> 4092
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 451
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccaccatgt     1740

acagaatgca gctgctgctg ctcattgccc tgtctctggc cctggtcacc aattctgaag     1800

tgcagctggt ggaaagtggt ggtggactgg tgcagcctgg cagaagcctg agactgtctt     1860

gtgctgcctc tggcttcacc tttgatgact atgccatgca ctgggtcaga caggcccctg     1920

gcaaaggact ggaatgggtg tcagccatca cctggaactc tggccacatt gactatgctg     1980

actctgtgga aggcagattc accatcagca gagacaatgc caagaacagc ctgtacctgc     2040

agatgaactc cctgagagct gaggacacag cagtgtacta ctgtgccaag gtgtcctacc     2100

tgagcacagc cagcagcctg gattattggg gccagggcac actggttaca gtgtcctctg     2160

ccagcacaaa gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg     2220

gaacagctgc cctgggctgt ctggtcaagg attacttccc tgagcctgtg acagtgtctt     2280

ggaactcagg ggctctgacc tctggggtgc acacatttcc agctgtgctg cagtcctctg     2340

gcctgtactc tctgtcctct gtggtcacag tgcctagctc tagcctgggc acccagacct     2400

acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag gtggaaccca     2460

agagctgtga caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc     2520

cttctgtgtt cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg     2580

aagtgacctg tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt     2640

atgtggatgg ggttgaagtg cacaatgcta agaccaagcc tagagaggaa cagtacaaca     2700

gcacctacag agtggtgtct gtgctgacag tgctgcatca ggactggctg aatggcaaag     2760

agtacaagtg caaagtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca     2820

aggccaaggg ccagccaaga gaaccccagg tttacacact gccacctagc agagatgagc     2880

tgaccaagaa ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg     2940

ctgtggaatg ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc     3000

tggactctga tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc     3060

agcaggggaa tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc     3120

agaaaagtct gagtctgagc cctggcaaga gaaagagaag aggctctgga gaaggcagag     3180

gctccctgct gacatgtggg gatgttgaag agaatcctgg gcctatgtat aggatgcaac     3240

tgctcctcct gattgctctg agcctggctc ttgtgaccaa ctctgacatc cagatgacac     3300

agagccctag cagcctgtct gcttctgtgg gagacagagt gaccatcaca tgcagagcca     3360

gccagggaat cagaaactac ctggcctggt atcagcaaaa gcctggcaag gcccctaagc     3420

tgctgatcta tgcagccagc acactgcagt caggggtgcc aagcagattt tcaggctctg     3480

gctctggcac agacttcacc ctgaccattt ctagcctgca gcctgaggat gtggccacct     3540

actactgcca gagatacaac agagccccat acacctttgg acagggcaca aaggtggaaa     3600

tcaagagaac agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga     3660

agtctggcac tgcctctgtt gtgtgcctgc tgaacaactt ctaccctaga gaagccaagg     3720

tgcagtggaa ggttgacaat gccctgcagt ctggcaatag ccaagaatct gtgacagagc     3780

aggactccaa ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact     3840

atgagaagca caaagtgtat gcctgtgaag tgacacacca gggactgagc agcccagtga     3900

ccaagagctt caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag     3960

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4020

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4080

gtctctcact cg                                                         4092


<210> 452
<211> 2193
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 452
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg      120

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      240

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      360

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      420

tctgccagca caaagggccc ctctgttttt ccactggctc ccagcagcaa gagcaccagt      480

ggtggaacag ctgccctggg ctgtctggtc aaggattact tccctgagcc tgtgacagtg      540

tcttggaact caggggctct gacctctggg gtgcacacat ttccagctgt gctgcagtcc      600

tctggcctgt actctctgtc ctctgtggtc acagtgccta gctctagcct gggcacccag      660

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      720

cccaagagct gtgacaagac ccacacctgt cctccatgtc ctgctccaga actgcttgga      780

ggcccttctg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      840

cctgaagtga cctgtgtggt ggttgatgtg tcccatgagg acccagaagt gaagttcaat      900

tggtatgtgg atggggttga agtgcacaat gctaagacca agcctagaga ggaacagtac      960

aacagcacct acagagtggt gtctgtgctg acagtgctgc atcaggactg gctgaatggc     1020

aaagagtaca agtgcaaagt gtccaacaag gccctgcctg ctcctattga gaaaaccatc     1080

tccaaggcca agggccagcc aagagaaccc caggtttaca cactgccacc tagcagagat     1140

gagctgacca agaaccaggt gtccctgacc tgcctggtta agggcttcta cccctctgac     1200

attgctgtgg aatgggagag caatggccag cctgagaaca actacaagac aacccctcct     1260

gtgctggact ctgatggctc attcttcctg tacagcaagc tgactgtgga caagtccaga     1320

tggcagcagg ggaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac     1380

acccagaaaa gtctgagtct gagccctggc aagagaaaga gaagaggctc tggagaaggc     1440

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     1500

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     1560

acacagagcc ctagcagcct gtctgcttct gtgggagaca gagtgaccat cacatgcaga     1620

gccagccagg gaatcagaaa ctacctggcc tggtatcagc aaaagcctgg caaggcccct     1680

aagctgctga tctatgcagc cagcacactg cagtcagggg tgccaagcag attttcaggc     1740

tctggctctg gcacagactt caccctgacc atttctagcc tgcagcctga ggatgtggcc     1800

acctactact gccagagata caacagagcc ccatacacct ttggacaggg cacaaaggtg     1860

gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag     1920

ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc     1980

aaggtgcagt ggaaggttga caatgccctg cagtctggca atagccaaga atctgtgaca     2040

gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct     2100

gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact gagcagccca     2160

gtgaccaaga gcttcaacag gggagagtgc tga                                  2193


<210> 453
<211> 3423
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 453
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccaccatgt     1740

acagaatgca gctgctgctg ctcattgccc tgtctctggc cctggtcacc aattctgaag     1800

tgcagctggt ggaaagtggt ggtggactgg tgcagcctgg cagaagcctg agactgtctt     1860

gtgctgcctc tggcttcacc tttgatgact atgccatgca ctgggtcaga caggcccctg     1920

gcaaaggact ggaatgggtg tcagccatca cctggaactc tggccacatt gactatgctg     1980

actctgtgga aggcagattc accatcagca gagacaatgc caagaacagc ctgtacctgc     2040

agatgaactc cctgagagct gaggacacag cagtgtacta ctgtgccaag gtgtcctacc     2100

tgagcacagc cagcagcctg gattattggg gccagggcac actggttaca gtgtcctctg     2160

ccagcacaaa gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg     2220

gaacagctgc cctgggctgt ctggtcaagg attacttccc tgagcctgtg acagtgtctt     2280

ggaactcagg ggctctgacc tctggggtgc acacatttcc agctgtgctg cagtcctctg     2340

gcctgtactc tctgtcctct gtggtcacag tgcctagctc tagcctgggc acccagacct     2400

acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag gtggaaccca     2460

agagctgtga caagacccac agaaagagaa gaggctctgg agaaggcaga ggctccctgc     2520

tgacatgtgg ggatgttgaa gagaatcctg ggcctatgta taggatgcaa ctgctcctcc     2580

tgattgctct gagcctggct cttgtgacca actctgacat ccagatgaca cagagcccta     2640

gcagcctgtc tgcttctgtg ggagacagag tgaccatcac atgcagagcc agccagggca     2700

tcagaaacta cctggcctgg tatcagcaga agccaggcaa ggcccctaag ctgctgatct     2760

atgcagccag cacactgcag agtggggtgc caagcagatt ttcaggctct ggctctggca     2820

cagacttcac cctgaccatt tctagcctgc agcctgagga tgtggccacc tactactgcc     2880

agagatacaa cagagcccca tacacctttg gacagggcac aaaggtggaa atcaagagaa     2940

cagttgcagc accctcagtt ttcatcttcc ccccctcaga tgaacagctg aagtctggca     3000

ctgcctctgt tgtgtgcctg ctgaacaact tctaccccag agaagccaag gtgcagtgga     3060

aggttgacaa tgccctgcag tcaggcaaca gccaagaatc tgtgactgaa caggattcca     3120

aggatagcac ctacagcctg agcagcaccc tgacactgag caaggctgac tatgagaagc     3180

acaaagtgta tgcctgtgaa gtgacccacc agggactgag cagcccagtg accaagagct     3240

tcaacagggg agagtgctga taactcgagg acggggtgaa ctacgcctga ggatccgatc     3300

tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg     3360

gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac     3420

tcg                                                                   3423


<210> 454
<211> 1524
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 454
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg      120

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      240

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      360

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      420

tctgccagca caaagggccc ctctgttttt ccactggctc ccagcagcaa gagcaccagt      480

ggtggaacag ctgccctggg ctgtctggtc aaggattact tccctgagcc tgtgacagtg      540

tcttggaact caggggctct gacctctggg gtgcacacat ttccagctgt gctgcagtcc      600

tctggcctgt actctctgtc ctctgtggtc acagtgccta gctctagcct gggcacccag      660

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      720

cccaagagct gtgacaagac ccacagaaag agaagaggct ctggagaagg cagaggctcc      780

ctgctgacat gtggggatgt tgaagagaat cctgggccta tgtataggat gcaactgctc      840

ctcctgattg ctctgagcct ggctcttgtg accaactctg acatccagat gacacagagc      900

cctagcagcc tgtctgcttc tgtgggagac agagtgacca tcacatgcag agccagccag      960

ggcatcagaa actacctggc ctggtatcag cagaagccag gcaaggcccc taagctgctg     1020

atctatgcag ccagcacact gcagagtggg gtgccaagca gattttcagg ctctggctct     1080

ggcacagact tcaccctgac catttctagc ctgcagcctg aggatgtggc cacctactac     1140

tgccagagat acaacagagc cccatacacc tttggacagg gcacaaaggt ggaaatcaag     1200

agaacagttg cagcaccctc agttttcatc ttccccccct cagatgaaca gctgaagtct     1260

ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ccagagaagc caaggtgcag     1320

tggaaggttg acaatgccct gcagtcaggc aacagccaag aatctgtgac tgaacaggat     1380

tccaaggata gcacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag     1440

aagcacaaag tgtatgcctg tgaagtgacc caccagggac tgagcagccc agtgaccaag     1500

agcttcaaca ggggagagtg ctga                                            1524


