                               SEQUENCE LISTING

<110> ALLOGENE THERAPEUTICS, INC.
 
<120> RITUXIMAB-RESISTANT CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

<130> AT-028/03WO

<140>
<141>

<150> 63/005,041
<151> 2020-04-03

<150> 62/839,455
<151> 2019-04-26

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 2019
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 1
atgctgacca gcctgctgtg ctggatggcc ctgtgcctgc tgggcgccga ccacgccgat       60

gcctgcccct acagcaaccc cagcctgtgc agcggaggcg gcggcagcga gctgcccacc      120

cagggcacct tctccaacgt gtccaccaac gtgagcccag ccaagcccac caccaccgcc      180

tgtccttatt ccaatccttc cctgtgtagc ggagggggag gcagcccagc ccccagacct      240

cccaccccag cccccaccat cgccagccag cctctgagcc tgagacccga ggcctgccgc      300

ccagccgccg gcggcgccgt gcacaccaga ggcctggatt tcgcctgcga tatctacatc      360

tgggccccac tggccggcac ctgtggcgtg ctgctgctga gcctggtgat caccctgtac      420

tgcaaccacc gcaaccgcag gcgcgtgtgc aagtgcccca ggcccgtggt gagagccgag      480

ggcagaggca gcctgctgac ctgcggcgac gtggaggaga acccaggccc catggagacc      540

gacaccctgc tgctgtgggt gctgctgctg tgggtgccag gcagcaccgg cgaggtgcag      600

ctgcagcaga gcggacccga gctgatcaag ccaggcgcca gcgtgaagat gagctgcaag      660

gccagcggct acaccttcac cagctacgtg atgcactggg tgaagcagaa gccaggccag      720

ggcctggagt ggatcggcta catcaacccc tacaacgacg gcaccaagta caacgagaag      780

ttcaagggca aggccaccct gaccagcgac aagagcagca gcaccgccta catggagctg      840

agcagcctga ccagcgagga cagcgccgtg tactactgcg ccagaggcac ctactactac      900

ggcagccggg tgttcgacta ctggggccag ggcaccaccc tgaccgtgag ctctggcgga      960

ggcggctctg gcggaggcgg ctctggcgga ggcggcagcg acatcgtgat gacccaggct     1020

gcccccagca tccccgtgac cccaggcgag agcgtgagca tcagctgccg gagcagcaag     1080

agcctgctga acagcaacgg caacacctac ctgtactggt tcctgcagcg gccaggccag     1140

agcccccagc tgctgatcta ccggatgagc aacctggcca gcggcgtgcc cgaccggttc     1200

agcggcagcg gcagcggcac cgccttcacc ctgcggatca gccgggtgga ggccgaggac     1260

gtgggcgtgt actactgcat gcagcacctg gagtacccct tcaccttcgg agccggcacc     1320

aagctggagc tgaagcggtc ggatcccacc accaccccag ccccacggcc acctacccct     1380

gccccaacca tcgccagcca gcccctgagc ctgcggcctg aagcctgcag gcctgccgcc     1440

ggaggagccg tgcacacaag gggcctggac ttcgcctgcg acatctatat ctgggccccc     1500

ctggccggga catgcggggt gctgctgctg tccctggtga ttacactgta ttgcaaacgg     1560

ggccggaaga agctgctgta catcttcaag cagcccttca tgcggcccgt gcagaccacc     1620

caggaggagg acggctgcag ctgccggttc cccgaggaag aggaaggcgg ctgcgagctg     1680

cgggtgaagt tcagccggag cgccgacgcc ccagcctacc agcagggcca gaaccagctg     1740

tacaacgagc tgaacctggg acggcgggag gagtacgacg tgctggacaa gcggcgggga     1800

cgggaccccg agatgggcgg caagcctcgc cggaagaatc cccaggaggg cctgtacaac     1860

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg     1920

cgccggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc     1980

tacgacgccc tgcacatgca ggccctgcca ccccggtga                            2019


<210> 2
<211> 1488
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 2
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gaggtgcagc tgcagcagag cggacccgag ctgatcaagc caggcgccag cgtgaagatg      120

agctgcaagg ccagcggcta caccttcacc agctacgtga tgcactgggt gaagcagaag      180

ccaggccagg gcctggagtg gatcggctac atcaacccct acaacgacgg caccaagtac      240

aacgagaagt tcaagggcaa ggccaccctg accagcgaca agagcagcag caccgcctac      300

atggagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc cagaggcacc      360

tactactacg gcagccgggt gttcgactac tggggccagg gcaccaccct gaccgtgagc      420

tctggcggag gcggctctgg cggaggcggc tctggcggag gcggcagcga catcgtgatg      480

acccaggctg cccccagcat ccccgtgacc ccaggcgaga gcgtgagcat cagctgccgg      540

agcagcaaga gcctgctgaa cagcaacggc aacacctacc tgtactggtt cctgcagcgg      600

ccaggccaga gcccccagct gctgatctac cggatgagca acctggccag cggcgtgccc      660

gaccggttca gcggcagcgg cagcggcacc gccttcaccc tgcggatcag ccgggtggag      720

gccgaggacg tgggcgtgta ctactgcatg cagcacctgg agtacccctt caccttcgga      780

gccggcacca agctggagct gaagcggtcg gatcccacca ccaccccagc cccacggcca      840

cctacccctg ccccaaccat cgccagccag cccctgagcc tgcggcctga agcctgcagg      900

cctgccgccg gaggagccgt gcacacaagg ggcctggact tcgcctgcga catctatatc      960

tgggcccccc tggccgggac atgcggggtg ctgctgctgt ccctggtgat tacactgtat     1020

tgcaaacggg gccggaagaa gctgctgtac atcttcaagc agcccttcat gcggcccgtg     1080

cagaccaccc aggaggagga cggctgcagc tgccggttcc ccgaggaaga ggaaggcggc     1140

tgcgagctgc gggtgaagtt cagccggagc gccgacgccc cagcctacca gcagggccag     1200

aaccagctgt acaacgagct gaacctggga cggcgggagg agtacgacgt gctggacaag     1260

cggcggggac gggaccccga gatgggcggc aagcctcgcc ggaagaatcc ccaggagggc     1320

ctgtacaacg agctgcagaa ggacaagatg gccgaggcct acagcgagat cggcatgaag     1380

ggcgagcggc gccggggcaa gggccacgac ggcctgtacc agggcctgag caccgccacc     1440

aaggacacct acgacgccct gcacatgcag gccctgccac cccggtga                  1488


<210> 3
<211> 1488
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 3
atggagacag ataccctgct gctgtgggtg ctgctgctgt gggtgcctgg ctccacagga       60

gaggtgcagc tgcagcagtc tggaccagag ctgatcaagc ctggagcatc cgtgaagatg      120

tcttgcaagg ccagcggcta tacattcacc agctacgtga tgcactgggt gaagcagaag      180

cctggccagg gcctggagtg gatcggctat atcaatccat acaacgacgg caccaagtat      240

aatgagaagt ttaagggcaa ggccacactg acctctgata agagctcctc tacagcctac      300

atggagctga gctccctgac ctctgaggac agcgccgtgt actattgcgc cagaggcaca      360

tactattacg gcagcagggt gttcgattac tggggccagg gcaccacact gaccgtgtct      420

agcggaggag gaggctccgg aggaggaggc tctggcggcg gcggcagcga catcgtgatg      480

acacaggcag caccaagcat cccagtgacc cctggcgaga gcgtgtccat ctcttgtcgg      540

tcctctaagt ccctgctgaa ctctaatggc aacacctatc tgtactggtt tctgcagcgg      600

cccggacagt ccccacagct gctgatctat aggatgagca acctggcatc cggagtgcct      660

gatcgcttca gcggctccgg ctctggaaca gcctttaccc tgaggatctc tcgggtggag      720

gcagaggacg tgggcgtgta ttactgcatg cagcacctgg agtacccctt cacatttggc      780

gcaggaacca agctggagct gaagcggagc gaccccacca caacccctgc accacggccc      840

cctacaccag cacctaccat cgcatctcag ccactgagcc tgcggcccga ggcctgtagg      900

cctgcagcag gaggagcagt gcacaccagg ggcctggact tcgcctgcga tatctatatc      960

tgggcaccac tggcaggaac atgtggcgtg ctgctgctga gcctggtcat caccctgtat     1020

tgcaagagag gcaggaagaa gctgctgtac atcttcaagc agccttttat gcggccagtg     1080

cagacaaccc aggaggagga tggctgctcc tgtagattcc cagaggagga ggagggagga     1140

tgtgagctgc gcgtgaagtt tagccggtcc gccgacgcac cagcatatca gcagggccag     1200

aatcagctgt acaatgagct gaacctgggc cggagagagg agtacgacgt gctggataag     1260

aggaggggaa gggaccccga gatgggaggc aagccacgga gaaagaatcc ccaggagggc     1320

ctgtataacg agctgcagaa ggataagatg gccgaggcct acagcgagat cggcatgaag     1380

ggagagaggc gccggggcaa gggacacgac ggcctgtatc agggcctgtc cacagccacc     1440

aaggacacct acgatgccct gcacatgcag gccctgccac caaggtga                  1488


<210> 4
<211> 1875
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 4
atgggaacaa gcctgctgtg ctggatggct ctgtgcctgc tgggggccga ccacgctgac       60

gcctccgggg gggggggctc tcctgcccct aggcccccta cacctgcacc aaccatcgca      120

tcccagccac tgtctctgcg ccctgaggcc tgccggccag cagcaggagg agcagtgcac      180

acccgcggcc tggacttcgc ctgcgatatc tatatctggg caccactggc aggcacatgt      240

ggcgtgctgc tgctgagcct ggtcatcacc ctgtactgca atcacaggaa ccggagaagg      300

gtgtgcaagt gtccccggcc tgtggtgaga gcagagggaa ggggcagcct gctgacatgt      360

ggcgacgtgg aggagaatcc aggccctatg gagacagata ccctgctgct gtgggtgctg      420

ctgctgtggg tgcccggcag caccggagag gtgcagctgc agcagtccgg accagagctg      480

atcaagcctg gagccagcgt gaagatgtcc tgtaaggcct ctggctatac attcaccagc      540

tacgtgatgc actgggtgaa gcagaagcct ggccagggcc tggagtggat cggctatatc      600

aatccataca acgacggcac aaagtataac gagaagttta agggcaaggc cacactgacc      660

tccgataaga gctcctctac agcctacatg gagctgagct ccctgacctc tgaggacagc      720

gccgtgtact attgcgccag aggcacatac tattacggct ctagggtgtt cgattactgg      780

ggccagggca ccacactgac cgtgtctagc ggaggaggag gcagcggagg aggaggctcc      840

ggcggcggcg gctctgacat cgtgatgaca caggcagcac catccatccc agtgacccct      900

ggcgagagcg tgtccatctc ttgtcggtcc tctaagagcc tgctgaactc caatggcaac      960

acctatctgt actggtttct gcagcggccc ggacagagcc cacagctgct gatctatagg     1020

atgtctaatc tggcaagcgg cgtgcccgat cgcttcagcg gctccggctc tggcacagcc     1080

tttaccctga ggatctcccg cgtggaggca gaggacgtgg gcgtgtatta ctgcatgcag     1140

cacctggagt accccttcac atttggcgca ggcaccaagc tggagctgaa gcggagcgac     1200

cccaccacaa cccctgcacc acggccaccc acaccagcac ctactattgc atcccagcca     1260

ctgagcctgc ggcccgaggc ctgtaggcct gccgccggcg gcgcagtgca cacccggggc     1320

ctggactttg cctgcgatat ctacatctgg gcacctctgg ccggcacatg cggcgtgctg     1380

ttactgagcc tggtcatcac cctgtattgc aagcggggca gaaagaagct gctgtacatc     1440

ttcaagcagc cttttatgcg gccagtgcag acaacccagg aggaggatgg ctgctcctgt     1500

agattcccag aggaggagga gggaggatgt gagctgcgcg tgaagtttag ccggtccgcc     1560

gacgcaccag catatcagca gggccagaac cagctgtaca atgagctgaa cctgggccgg     1620

agagaggagt atgacgtgct ggataagaga cggggccggg accccgagat gggaggcaag     1680

ccacgccgga agaatcccca ggagggcctg tataacgagc tgcagaagga taagatggcc     1740

gaggcctaca gcgagatcgg catgaaggga gagagaaggc gcggcaaggg acacgacggc     1800

ctgtaccagg gcctgagcac agcaacaaaa gacacctacg acgcactgca catgcaggct     1860

ctgccccctc ggtaa                                                      1875


<210> 5
<211> 1941
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 5
atgggaacct ctctgctgtg ctggatggct ctgtgcctgc tgggggccga tcacgctgac       60

gcaagtggcg ggggggggtc cgaactgccc acacagggca ccttctccaa cgtgagcacc      120

aacgtgagct ccggcggagg aggcagccct gcaccaaggc cccctacacc agcacctacc      180

atcgcatctc agccactgag cctgcgcccc gaggcctgcc ggcctgcagc aggcggcgcc      240

gtgcacaccc gcggcctgga ctttgcctgc gatatctata tctgggcacc tctggcaggc      300

acatgtggcg tgctgctgct gagcctggtc atcaccctgt actgcaatca caggaaccgg      360

agaagggtgt gcaagtgtcc acggcccgtg gtgagagcag agggaagggg ctccctgctg      420

acatgtggcg acgtggagga gaatcctggc ccaatggaga cagataccct gctgctgtgg      480

gtgctgctgc tgtgggtgcc cggctccacc ggagaggtgc agctgcagca gtctggacca      540

gagctgatca agccaggagc atccgtgaag atgtcttgta aggccagcgg ctatacattc      600

accagctacg tgatgcactg ggtgaagcag aagccaggac agggcctgga gtggatcggc      660

tatatcaatc cttacaacga cggcaccaag tataacgaga agtttaaggg caaggccaca      720

ctgacctctg ataagtctag ctccacagcc tacatggagc tgtctagcct gaccagcgag      780

gactccgccg tgtactattg cgccagaggc acatactatt acggcagcag ggtgttcgat      840

tactggggcc agggcaccac actgaccgtg tcctctggag gaggaggctc cggaggagga      900

ggctctggcg gcggcggcag cgacatcgtg atgacacagg cagcaccttc catcccagtg      960

accccaggcg agtctgtgag catctcctgt cggagctcca agtccctgct gaactctaat     1020

ggcaacacct atctgtactg gtttctgcag cggcccggac agtccccaca gctgctgatc     1080

tataggatga gcaatctggc ctccggcgtg ccagatcgct tctctggcag cggctccggc     1140

acagccttta ccctgaggat ctctcgcgtg gaggcagagg acgtgggcgt gtattactgc     1200

atgcagcacc tggagtaccc attcacattt ggcgcaggca ccaagctgga gctgaagcgg     1260

agcgacccca ccacaacccc agcacctcgg ccacccacac cagcacccac catcgcatct     1320

cagcctctga gcctgcggcc cgaggcctgt aggcccgcag caggaggagc agtgcacacc     1380

cggggcctgg acttcgcctg cgatatctac atctgggcac cactggccgg cacatgcggc     1440

gtgctgttac tgagcctggt catcaccctg tattgcaagc ggggcagaaa gaagctgctg     1500

tacatcttca agcagccctt tatgcggcct gtgcagacaa cccaggagga ggatggctgc     1560

tcctgtagat tccctgagga ggaggaggga ggatgtgagc tgcgcgtgaa gttttctcgg     1620

agcgccgacg caccagcata tcagcaggga cagaaccagc tgtacaatga gctgaacctg     1680

ggccggagag aggagtatga cgtgctggat aagagacggg gccgggaccc cgagatggga     1740

ggcaagcctc gccggaagaa tccacaggag ggcctgtata acgagctgca gaaggataag     1800

atggccgagg cctacagcga gatcggcatg aagggagaga gaaggcgcgg caagggacac     1860

gacggcctgt accagggcct gagcacagca acaaaagaca cctacgacgc actgcacatg     1920

caggctctgc caccaagatg a                                               1941


<210> 6
<211> 2019
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 6
atggggacct cactgctgtg ctggatggct ctgtgcctgc tgggggccga ccacgctgac       60

gcctgctctg gggggggggg gggctcatgc tccggaggag gaggctctga gctgccaacc      120

cagggcacat tctccaacgt gagcaccaac gtgtctcctg ccaagccaac cacaaccgca      180

tgcagcggcg gaggaggagg cagctgttcc ggcggcggcg gcagccctgc cccaaggccc      240

cctaccccag cacctacaat cgcatctcag cctctgagcc tgcgcccaga ggcctgtcgg      300

cccgcagcag gaggagcagt gcacacccgc ggcctggact ttgcctgcga tatctatatc      360

tgggcaccac tggcaggcac ctgtggcgtg ctgctgctga gcctggtcat caccctgtac      420

tgcaatcaca ggaaccggag aagggtgtgc aagtgtccac ggcccgtggt gagagcagag      480

ggaaggggct ctctgctgac ctgtggcgac gtggaggaga atcctggccc tatggagaca      540

gatacactgc tgctgtgggt gctgctgctg tgggtgcccg gcagcacagg agaggtgcag      600

ctgcagcagt ccggacctga gctgatcaag ccaggcgcct ccgtgaagat gtcttgcaag      660

gccagcggct ataccttcac aagctacgtg atgcactggg tgaagcagaa gccaggccag      720

ggcctggagt ggatcggcta tatcaatccc tacaacgacg gcaccaagta taacgagaag      780

tttaagggca aggccaccct gacaagcgat aagagctcct ctaccgccta catggagctg      840

agctccctga caagcgagga ctccgccgtg tactattgcg ccagaggcac ctactattac      900

ggctccaggg tgttcgatta ctggggccag ggcacaaccc tgacagtgtc tagcggagga      960

ggaggcagcg gaggaggagg ctccggcggc ggcggctctg acatcgtgat gacccaggca     1020

gcaccatcca tccctgtgac accaggcgag tctgtgagca tctcctgtcg gtcctctaag     1080

tccctgctga actctaatgg caacacctat ctgtactggt ttctgcagcg gcccggacag     1140

tctcctcagc tgctgatcta taggatgagc aatctggcct ccggcgtgcc tgatcgcttc     1200

tctggcagcg gctccggcac cgcctttaca ctgaggatca gccgcgtgga ggcagaggac     1260

gtgggcgtgt attactgcat gcagcacctg gagtaccctt tcacctttgg cgccggcaca     1320

aagctggagc tgaagcggag cgaccccaca accacaccag cacctcggcc acccacccca     1380

gcaccaacaa tcgcatctca gccactgagc ctgcggcccg aggcctgtag gccagccgcc     1440

ggcggcgcag tgcacacccg gggcctggac ttcgcctgcg atatctacat ctgggcccct     1500

ctggccggca cctgcggcgt gctgttactg agcctggtca tcaccctgta ttgcaagcgg     1560

ggcagaaaga agctgctgta catcttcaag cagcccttca tgcggcccgt gcagaccaca     1620

caggaggagg atggctgctc ctgtagattc ccagaggagg aggagggagg atgtgagctg     1680

cgcgtgaagt tttctcggag cgccgacgca cctgcatatc agcagggaca gaaccagctg     1740

tacaatgagc tgaacctggg ccggagagag gagtatgacg tgctggataa gagacggggc     1800

cgggaccccg agatgggagg caagccccgc cggaagaatc ctcaggaggg cctgtataac     1860

gagctgcaga aggataagat ggccgaggcc tacagcgaga tcggcatgaa gggagagaga     1920

aggcgcggca agggccacga cggcctgtac cagggcctgt ccacagcaac aaaggatact     1980

tatgacgctc tgcacatgca ggctctgccc cctcggtga                            2019


<210> 7
<211> 2061
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 7
atgggaacca gcctgctgtg ctggatggca ctgtgcctgc tgggagcaga ccacgccgat       60

gccgaactgc ctactcaggg gacattctct aatgtgagca ccaacgtgag ctctggagga      120

ggaggctccg agctgccaac ccagggcaca ttctctaatg tgagcacaaa cgtgtctccc      180

gccaagccta ccacaaccgc cgaactgcct acccagggca cattttccaa cgtgtctacc      240

aacgtgtcta gcggaggagg aggctccccc gcacctaggc cccctacccc agcaccaaca      300

atcgcaagcc agcctctgtc cctgcgccca gaggcatgca ggccagcagc aggaggagca      360

gtgcacaccc gcggcctgga ctttgcctgc gatatctata tctgggcacc actggcagga      420

acctgtggcg tgctgctgct gtctctggtc atcaccctgt actgcaatca cagaaaccgg      480

agaagggtgt gcaagtgtcc tcggccagtg gtgagagcag agggaagggg cagcctgctg      540

acctgtggcg acgtggagga gaatcccggc cctatggaga cagatacact gctgctgtgg      600

gtgctgctgc tgtgggtgcc aggctctaca ggagaggtgc agctgcagca gagcggacct      660

gagctgatca agccaggcgc ctctgtgaag atgagctgca aggcctccgg ctataccttc      720

acaagctacg tgatgcactg ggtgaagcag aagccaggcc agggcctgga gtggatcggc      780

tatatcaatc cctacaacga cggcaccaag tataacgaga agtttaaggg caaggccacc      840

ctgacatccg ataagagctc ctctaccgcc tacatggagc tgagctccct gacatccgag      900

gactctgccg tgtactattg cgccagaggc acctactatt acggctctag ggtgttcgat      960

tactggggcc agggcacaac cctgacagtg tctagcggag gaggaggctc tggaggagga     1020

ggcagcggcg gcggaggctc cgacatcgtg atgacccagg cagcaccatc catcccagtg     1080

acacctggcg agagcgtgtc catctcttgt aggtcctcta agtctctgct gaacagcaat     1140

ggcaacacct atctgtactg gtttctgcag cggcccggac agagccctca gctgctgatc     1200

tataggatgt ccaatctggc ctctggagtg cctgatcgct tcagcggctc cggctctgga     1260

accgccttta cactgaggat ctcccgcgtg gaggcagagg acgtgggcgt gtattactgc     1320

atgcagcacc tggagtaccc tttcaccttt ggcgccggca caaagctgga gctgaagcgg     1380

agcgacccca caaccacacc agcaccccgg ccaccaaccc ctgcccctac aatcgcaagc     1440

cagccactgt ccctgcggcc cgaggcctgt agacctgccg ccggcggcgc cgtccatacc     1500

cgcggcctgg atttcgcctg cgatatctac atttgggccc ctctggccgg cacttgcggc     1560

gtgctgctgc tgagcctggt catcaccctg tattgcaagc ggggcagaaa gaagctgctg     1620

tacatcttca agcagccctt catgcggccc gtgcagacca cacaggagga ggatggctgc     1680

tcctgtagat tcccagagga ggaggaggga ggatgtgagc tgcgcgtgaa gtttagccgg     1740

tccgccgacg cacctgcata tcagcagggc cagaaccagc tgtacaatga gctgaacctg     1800

ggccggagag aggagtacga cgtgctggat aagagaaggg gacgggaccc cgagatggga     1860

ggcaagcccc gccggaagaa tcctcaggag ggcctgtata acgagctgca gaaggataag     1920

atggccgagg cctacagcga gatcggcatg aagggagaga gaaggcgcgg caagggacac     1980

gacggcctgt atcagggcct gtccaccgcc acaaaggaca cctacgatgc cctgcacatg     2040

caggccctgc ctccaagatg a                                               2061


<210> 8
<211> 672
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 8
Met Leu Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Arg Ala Glu 
145                 150                 155                 160 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                165                 170                 175     


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
            180                 185                 190         


Pro Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
        195                 200                 205             


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
225                 230                 235                 240 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
                245                 250                 255     


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
            260                 265                 270         


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
        275                 280                 285             


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
    290                 295                 300                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
                325                 330                 335     


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
            340                 345                 350         


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
        355                 360                 365             


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
    370                 375                 380                 


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
385                 390                 395                 400 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
                405                 410                 415     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
            420                 425                 430         


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
        435                 440                 445             


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    450                 455                 460                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
465                 470                 475                 480 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                485                 490                 495     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            500                 505                 510         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        515                 520                 525             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    530                 535                 540                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
545                 550                 555                 560 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                565                 570                 575     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            580                 585                 590         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        595                 600                 605             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    610                 615                 620                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
625                 630                 635                 640 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                645                 650                 655     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670         


<210> 9
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 9
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu 
        195                 200                 205             


Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro 
                245                 250                 255     


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210> 10
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 10
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu 
        195                 200                 205             


Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro 
                245                 250                 255     


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210> 11
<211> 624
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 11
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
            20                  25                  30          


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        35                  40                  45              


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    50                  55                  60                  


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
65                  70                  75                  80  


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
                85                  90                  95      


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Arg Ala Glu 
            100                 105                 110         


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        115                 120                 125             


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
    130                 135                 140                 


Pro Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
        195                 200                 205             


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
                245                 250                 255     


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
        275                 280                 285             


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
    290                 295                 300                 


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
305                 310                 315                 320 


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
                325                 330                 335     


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
        355                 360                 365             


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
    370                 375                 380                 


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
385                 390                 395                 400 


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210> 12
<211> 646
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 12
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Ser Gly Gly Gly Gly Ser Glu Leu Pro Thr Gln 
            20                  25                  30          


Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    50                  55                  60                  


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
65                  70                  75                  80  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                85                  90                  95      


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            100                 105                 110         


Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
        115                 120                 125             


Pro Val Val Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
    130                 135                 140                 


Val Glu Glu Asn Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp 
145                 150                 155                 160 


Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Gln 
                165                 170                 175     


Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser 
            180                 185                 190         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val 
        195                 200                 205             


Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro 
    210                 215                 220                 


Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
225                 230                 235                 240 


Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser 
                245                 250                 255     


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr 
            260                 265                 270         


Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
        275                 280                 285             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val 
305                 310                 315                 320 


Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
                325                 330                 335     


Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro 
            340                 345                 350         


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser 
        355                 360                 365             


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
    370                 375                 380                 


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
385                 390                 395                 400 


Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu 
                405                 410                 415     


Glu Leu Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            420                 425                 430         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        435                 440                 445             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    450                 455                 460                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
465                 470                 475                 480 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                485                 490                 495     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            500                 505                 510         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        515                 520                 525             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    530                 535                 540                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
545                 550                 555                 560 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                565                 570                 575     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            580                 585                 590         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        595                 600                 605             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    610                 615                 620                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
625                 630                 635                 640 


Gln Ala Leu Pro Pro Arg 
                645     


<210> 13
<211> 672
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 13
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Ser Gly Gly Gly Gly Gly Ser Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Gly Ser Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Arg Ala Glu 
145                 150                 155                 160 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                165                 170                 175     


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
            180                 185                 190         


Pro Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
        195                 200                 205             


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
225                 230                 235                 240 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
                245                 250                 255     


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
            260                 265                 270         


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
        275                 280                 285             


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
    290                 295                 300                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
                325                 330                 335     


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
            340                 345                 350         


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
        355                 360                 365             


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
    370                 375                 380                 


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
385                 390                 395                 400 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
                405                 410                 415     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
            420                 425                 430         


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
        435                 440                 445             


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    450                 455                 460                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
465                 470                 475                 480 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                485                 490                 495     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            500                 505                 510         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        515                 520                 525             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    530                 535                 540                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
545                 550                 555                 560 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                565                 570                 575     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            580                 585                 590         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        595                 600                 605             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    610                 615                 620                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
625                 630                 635                 640 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                645                 650                 655     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670         


<210> 14
<211> 686
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="chimeric antigen receptor"

<400> 14
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val 
            20                  25                  30          


Ser Thr Asn Val Ser Ser Gly Gly Gly Gly Ser Glu Leu Pro Thr Gln 
        35                  40                  45              


Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Pro Ala Lys Pro Thr 
    50                  55                  60                  


Thr Thr Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr 
65                  70                  75                  80  


Asn Val Ser Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr 
                85                  90                  95      


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            100                 105                 110         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        115                 120                 125             


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
    130                 135                 140                 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
145                 150                 155                 160 


Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Arg Ala Glu Gly Arg 
                165                 170                 175     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            180                 185                 190         


Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly 
        195                 200                 205             


Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys 
    210                 215                 220                 


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
225                 230                 235                 240 


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
                245                 250                 255     


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
            260                 265                 270         


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
        275                 280                 285             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
    290                 295                 300                 


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp 
305                 310                 315                 320 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
            340                 345                 350         


Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
        355                 360                 365             


Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr 
    370                 375                 380                 


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
385                 390                 395                 400 


Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
                405                 410                 415     


Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
            420                 425                 430         


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe 
        435                 440                 445             


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Thr 
    450                 455                 460                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
465                 470                 475                 480 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                485                 490                 495     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            500                 505                 510         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        515                 520                 525             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    530                 535                 540                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
545                 550                 555                 560 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                565                 570                 575     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            580                 585                 590         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        595                 600                 605             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    610                 615                 620                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
625                 630                 635                 640 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                645                 650                 655     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            660                 665                 670         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 685     


<210> 15
<211> 1189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="artificial promoter"

<400> 15
gcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag       60

ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg      120

gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata      180

agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacaggta      240

agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc ttgcgtgcct      300

tgaattactt ccacgcccct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtga                 1189


<210> 16
<211> 237
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="promoter"

<400> 16
gcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag       60

ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg      120

gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata      180

agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacag         237


<210> 17
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="immunoglobulin gamma 1 heavy chain"

<400> 17
Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210> 18
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="immunoglobulin kappa light chain"

<400> 18
Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210> 19
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="rituximab binding sequence"

<400> 19
Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Pro 
            20                  25                  30          


Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    50                  55                  60                  


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
65                  70                  75                  80  


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                85                  90                  95      


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            100                 105                 110         


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
        115                 120                 125             


Cys Lys Cys Pro Arg Pro Val Val 
    130                 135     


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="signal peptide"

<400> 20
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala 
            20      


<210> 21
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
145                 150                 155         


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
1               5                   


<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Cys Gln Phe Asp Leu Ser Thr Arg Arg Leu Lys Cys 
1               5                   10          


<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Cys Gln Tyr Asn Leu Ser Ser Arg Ala Leu Lys Cys 
1               5                   10          


<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Cys Val Trp Gln Arg Trp Gln Lys Ser Tyr Val Cys 
1               5                   10          


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Cys Met Trp Asp Arg Phe Ser Arg Trp Tyr Lys Cys 
1               5                   10          


<210> 28
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp 
1               5                   10                  15      


Lys Leu Ala Ala Phe Pro Glu Asp Arg 
            20                  25  


<210> 29
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
1               5                   10                  15      


Ile Lys Glu 
            


<210> 30
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Gly Gln Asn Asp Thr Ser Gln Thr Ser Ser Pro Ser 
1               5                   10          


<210> 32
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      


<210> 33
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 34
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 35
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210> 36
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr 
65      


<210> 37
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 38
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 39
<211> 943
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="intron"

<400> 39
gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg       60

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt      120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg      180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc      240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac      300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc      360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag      420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc      480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc      540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag      600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa      660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc      720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg      780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg      840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct      900

caagcctcag acagtggttc aaagtttttt tcttccattt cag                        943


<210> 40
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="mutated rituximab binding sequences"

<400> 40
Cys Ser Gly Gly Gly Gly Gly Ser Cys Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Pro 
            20                  25                  30          


Ala Lys Pro Thr Thr Thr Ala Cys Ser Gly Gly Gly Gly Gly Ser Cys 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    50                  55                  60                  


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
65                  70                  75                  80  


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                85                  90                  95      


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            100                 105                 110         


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
        115                 120                 125             


Cys Lys Cys Pro Arg Pro Val Val 
    130                 135     


<210> 41
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(25) 
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 41
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


