                         SEQUENCE LISTING

<110>  bluebird bio, Inc.
       Seattle Children's Hospital d/b/a Seattle Children's 
       Research Institute
       Gay, Joel
       Khan, Iram F.
       Mann, Jasdeep
       Rawlings, David J.
       Wang, Yupeng
 
<120>  WISKOTT-ALDRICH SYNDROME GENE HOMING ENDONUCLEASE VARIANTS, 
       COMPOSITIONS, AND METHODS OF USE

<130>  BLBD-117/01WO 315698-3166

<150>  US 62/837,996
<151>  2019-04-24

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi

<400>  1

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Cys Val Met Glu Asn Lys Glu His Leu Lys Ile Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Ile Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  2
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi

<400>  2

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  3
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(3)
<223>  Any amino acid or absent

<400>  3

Xaa Xaa Xaa Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  4
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Any amino acid or absent

<400>  4

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  5
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Any amino acid or absent

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  6
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  6

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Arg Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Leu Glu Lys Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  7
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  7

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Arg Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Gln Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Ser Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Asn Leu Ile Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Leu Glu Lys Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  8
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  8

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Arg Val Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Ser Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Gln Glu Lys Asn Lys Ser Gly Ser Arg Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  9
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  9

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Phe Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Val Asn Ile Arg Tyr Glu Thr Gly Leu Val Phe Gly Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Asn Leu Asn Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Arg Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Gln Glu Lys Asn Lys Ser Glu Ser Ser Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  10
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  10

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Arg Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Gly Ile Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn His Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Leu Glu Lys Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Arg Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  11
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  11

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Arg Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Phe Leu Asn Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Leu Glu Lys Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Glu Lys Ile Ile Pro Val Phe Arg Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  12
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - reprogrammed I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Xaa is any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Xaa is any amino acid or absent

<400>  12

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg 
            20                  25                  30          


Asn Arg Arg Ile Ala Arg Tyr Glu Thr Gly Leu Glu Phe Lys Ile Ser 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr 
            180                 185                 190         


His Val Thr Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Leu Glu Lys Ile Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asn Lys Ile Ile Pro Val Phe Arg Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  13
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  13

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  14
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  14

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Gln Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Ser Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Asn Leu Ile Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  15
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  15

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Val Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Ser Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Gln Glu Lys 
            820                 825                 830         


Asn Lys Ser Gly Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  16
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  16

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Phe Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Val 
625                 630                 635                 640 


Asn Ile Arg Tyr Glu Thr Gly Leu Val Phe Gly Ile Thr Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Asn Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Arg Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Gln Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Ser Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  17
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  17

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Ile Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn His Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Arg 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  18
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  18

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Phe Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Glu Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  19
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL polypeptide construct

<400>  19

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Gly Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Ile Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asn Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905     


<210>  20
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  20

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  21
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  21

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Gln Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Ser Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Asn Leu Ile Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  22
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  22

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Val Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Ser Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Gln Glu Lys 
            820                 825                 830         


Asn Lys Ser Gly Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  23
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  23

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Phe Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Val 
625                 630                 635                 640 


Asn Ile Arg Tyr Glu Thr Gly Leu Val Phe Gly Ile Thr Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Asn Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Arg Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Gln Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Ser Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  24
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  24

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Ile Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn His Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Arg 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  25
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  25

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Ser Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Tyr Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Phe Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Asn Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Glu Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  26
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - MegaTAL-TREX2 polypeptide fusion construct

<400>  26

Met Gly Ser Cys Arg Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        275                 280                 285             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
305                 310                 315                 320 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            340                 345                 350         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ser 
    530                 535                 540                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
545                 550                 555                 560 


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
                565                 570                 575     


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
            580                 585                 590         


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser 
        595                 600                 605             


Arg Val Gly Gly Ser Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala 
    610                 615                 620                 


Asp Ala Glu Gly Thr Phe Leu Leu Arg Ile Arg Asn Arg Asn Arg Arg 
625                 630                 635                 640 


Ile Ala Arg Tyr Glu Thr Gly Leu Glu Phe Lys Ile Ser Leu His Asn 
                645                 650                 655     


Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly 
            660                 665                 670         


Lys Ile Asn Asn Ser Gly Asp Arg Tyr Val Thr Leu Arg Val Thr Arg 
        675                 680                 685             


Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu 
    690                 695                 700                 


Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln Ala Phe Ser 
705                 710                 715                 720 


Leu Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu 
                725                 730                 735     


Val Arg Ile Arg Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys 
            740                 745                 750         


Lys Ala Phe Pro Glu Asn Ile Gly Lys Glu Arg Pro Leu Ile Asn Lys 
        755                 760                 765             


Asn Ile Pro Asn Leu Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly 
    770                 775                 780                 


His Phe Gly Val Ile Leu Asn Lys Arg Lys Thr Gly Thr His Val Thr 
785                 790                 795                 800 


Val Arg Leu Val Phe Gly Ile Ser Gln His Ile Arg Asp Lys Asn Leu 
                805                 810                 815     


Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile Leu Glu Lys 
            820                 825                 830         


Ile Lys Ser Glu Ser Arg Trp Leu Asp Phe Arg Val Thr Lys Phe Ser 
        835                 840                 845             


Asp Ile Asn Asn Lys Ile Ile Pro Val Phe Arg Glu Asn Thr Leu Ile 
    850                 855                 860                 


Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu 
865                 870                 875                 880 


Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys 
                885                 890                 895     


Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly 
            900                 905                 910         


Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala 
        915                 920                 925             


Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe 
    930                 935                 940                 


Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly 
945                 950                 955                 960 


Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys 
                965                 970                 975     


Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser 
            980                 985                 990         


Ser Glu Ser Leu Met His Cys Gly  Lys Ala Gly Phe Asn  Gly Ala Val 
        995                 1000                 1005             


Val Arg  Thr Leu Gln Gly Phe  Leu Ser Arg Gln Glu  Gly Pro Ile 
    1010                 1015                 1020             


Cys Leu  Val Ala His Asn Gly  Phe Asp Tyr Asp Phe  Pro Leu Leu 
    1025                 1030                 1035             


Cys Thr  Glu Leu Gln Arg Leu  Gly Ala His Leu Pro  Gln Asp Thr 
    1040                 1045                 1050             


Val Cys  Leu Asp Thr Leu Pro  Ala Leu Arg Gly Leu  Asp Arg Ala 
    1055                 1060                 1065             


His Ser  His Gly Thr Arg Ala  Gln Gly Arg Lys Ser  Tyr Ser Leu 
    1070                 1075                 1080             


Ala Ser  Leu Phe His Arg Tyr  Phe Gln Ala Glu Pro  Ser Ala Ala 
    1085                 1090                 1095             


His Ser  Ala Glu Gly Asp Val  His Thr Leu Leu Leu  Ile Phe Leu 
    1100                 1105                 1110             


His Arg  Ala Pro Glu Leu Leu  Ala Trp Ala Asp Glu  Gln Ala Arg 
    1115                 1120                 1125             


Ser Trp  Ala His Ile Glu Pro  Met Tyr Val Pro Pro  Asp Gly Pro 
    1130                 1135                 1140             


Ser Leu  Glu Ala 
    1145         


<210>  27
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  27
tccccaccgt ttcttcctct tc                                                22


<210>  28
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  28
ctcctgcccc cg                                                           12


<210>  29
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  29

Cys Thr Cys Cys Thr Gly Cys Cys Cys Cys Cys Gly Cys Cys Cys Cys 
1               5                   10                  15      


Gly Thr Cys Cys Cys Cys Ala Cys Cys Gly Thr Thr Thr Cys Thr Thr 
            20                  25                  30          


Cys Cys Thr Cys Thr Thr Cys 
        35                  


<210>  30
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  30
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggaacuuuc uugcuacgua uccguaaccg uaacagacgu     1920

aucgccaggu acgagacuag ucuggaauuc aagaucaguc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucaauaacag uggcgaccgu     2040

uaugucacuc ugagagucac gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaugu uguuuaaaca ggcauucagc     2160

cucauggaga acaaagaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuggc     2280

aaagagcgcc cccuuaucaa uaagaacauu ccgaaucuca aauggcuggc uggauucaca     2340

ucuggugacg gccauuucgg cgugauucua aacaagcgua aaacagguac ucauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca agaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccua gagaaaaaca agucugagag uagauggcuc     2520

gauuucaggg uaacaaaauu cagcgauauu aacgacaaga ucauuccggu auuccgggaa     2580

aauacucuga uuggggucaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaagaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  31
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  31
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggaacuuuc uugcuacgua uccguaaccg uaacagacgu     1920

aucgccaggu acgagacuag ucuggaauuc aagaucaguc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucaauaacag uggcgaccgc     2040

uaugucacuc ugagagucac gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaugu uguuuaaaca ggcauucagc     2160

cucauggaga acaaagaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuggc     2280

aaagagcgcc cccuuaucaa uaagaacauu ccgaaucuca aauggcuggc uggauucaca     2340

ucuggugacg gccauuucgg cgugauucua aacaagcgua aaacagguac acauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca agaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccua gagaaaaaca agucugagag uagauggcuc     2520

gauuucaggg uaacaaaauu cagcgauauu aacgaaaaga ucauuccggu auuccgggaa     2580

aauacucuga uuggggucaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaagaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  32
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  32
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggaacuuuc uugcuacgua uccguaaccg uaacagacgu     1920

gucgccaggu acgagacuag ucuggaauuc aagaucaguc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucuauaacag uggcgaccgc     2040

uaugucacuc ugagagucuc gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaagu uguuuaaaca ggcguucagc     2160

gucauggaga acaaagaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuggc     2280

aaagagcgcc cccuuaucaa uaagaacauu ccgaaucuca aauggcuggc uggauucaca     2340

uccggugacg gccauuucgg cgugauucua aacaagcgua aaacagguac acauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca agaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccaa gagaaaaaca agucugggag cagauggcuc     2520

gauuucaggg uaacaaaauu cagcgauauu aacgacaaga ucauuccggu guuccaggaa     2580

aauacucuga uuggcguaaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaagaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  33
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  33
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggauuuuuc uugcuacgua uccguaacag aaacagagug     1920

aacaucagau acgagacugg ucugguauuc gggaucacuc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucuauaacag uggcgaccgu     2040

uaugucacuc ugagagucac gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaugu uguuuaaaca ggcauucagc     2160

cucauggaga acaaagaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuggc     2280

aaagagcgcc cccuuaucaa uaagaacauu ccgaaucuca aauggcuggc uggauucaca     2340

ucuggugacg gccauuucgg cgugaaucua aacaagcgua aaacagguac ucauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca ggaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccaa gagaaaaaca agucugagag uaguuggcuc     2520

gauuucaggg uaacaaaauu cagcgauauc aacgacaaga ucauuccggu auuccgggaa     2580

aauacucuga uuggggucaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaagaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  34
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  34
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggaacuuuc uugcuacgua uccguaaccg uaacagacgu     1920

aucgccaggu acgagacuag ucuggaauuc aagaucaguc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucaauaacag uggcgaccgu     2040

uaugucacuc ugagagucac gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaugu uguuuaaaca ggcauucagc     2160

cucauggaga acaaagaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuggc     2280

auagagcgcc cccuuaucaa uaagaacauu ccgaaucaca aauggcuggc uggauucaca     2340

ucuggugacg gccauuucgg cgugauucua aacaagcgua aaacagguac ucauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca agaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccua gagaaaaaca agucugagag uagauggcuc     2520

gauuucaggg uaacaaaauu cagcgauauu aacgacaaga ucauuccggu auuccgggaa     2580

aauacucuga uuggggucaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaggaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  35
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  35
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggaacuuuc uugcuacgua uccguaaccg uaacagacgu     1920

aucgccaggu acgagacuag ucuggaauuc aagaucaguc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucuauaacag uggcgaccgu     2040

uaugucacuc ugagagucac gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaugu uguuuaaaca ggcauucagc     2160

cucauggaga acaaggaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuagc     2280

aaagagcgcc cccuuaucaa uaagaacauu ccgaaucuca aauggcuggc uggauucaca     2340

ucuggugacg gccauuucgg cguguuucua aacaagcgua aaacagguac acauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca agaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccua gagaaaaaca agucugagag uagauggcuc     2520

gauuucaggg uaacaaaauu cagcgauauu aacgaaaaga ucauuccggu auuccgggaa     2580

aauacucuga uuggggucaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaagaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  36
<211>  2718
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - megaTAL polynucleotide construct

<400>  36
augggauccu gcaggccacc uaagaagaaa cgcaaagucg uggaucuacg cacgcucggc       60

uacagucagc agcagcaaga gaagaucaaa ccgaaggugc guucgacagu ggcgcagcac      120

cacgaggcac uggugggcca uggguuuaca cacgcgcaca ucguugcgcu cagccaacac      180

ccggcagcgu uagggaccgu cgcugucacg uaucagcaca uaaucacggc guugccagag      240

gcgacacacg aagacaucgu uggcgucggc aaacaguggu ccggcgcacg cgcccuggag      300

gccuugcuca cggaugcggg ggaguugaga gguccgccgu uacaguugga cacaggccaa      360

cuugugaaga uugcaaaacg uggcggcgug accgcaaugg aggcagugca ugcaucgcgc      420

aaugcacuga cgggugcccc ccugaaccug accccggacc aagugguggc uaucgccagc      480

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag      540

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacggugg cggcaagcaa      600

gcgcucgaaa cggugcagcg gcuguugccg gugcugugcc aggaccaugg ccugacuccg      660

gaccaagugg uggcuaucgc cagccacgau ggcggcaagc aagcgcucga aacggugcag      720

cggcuguugc cggugcugug ccaggaccau ggccugacuc cggaccaagu gguggcuauc      780

gccagccacg auggcggcaa gcaagcgcuc gaaacggugc agcggcuguu gccggugcug      840

ugccaggacc auggccugac cccggaccaa gugguggcua ucgccagcaa cgguggcggc      900

aagcaagcgc ucgaaacggu gcagcggcug uugccggugc ugugccagga ccauggccug      960

accccggacc aagugguggc uaucgccagc aacaauggcg gcaagcaagc gcucgaaacg     1020

gugcagcggc uguugccggu gcugugccag gaccauggcc ugaccccgga ccaaguggug     1080

gcuaucgcca gccacgaugg cggcaagcaa gcgcucgaaa cggugcagcg gcuguugccg     1140

gugcugugcc aggaccaugg ccugaccccg gaccaagugg uggcuaucgc cagccacgau     1200

ggcggcaagc aagcgcucga aacggugcag cggcuguugc cggugcugug ccaggaccau     1260

ggccugaccc cggaccaagu gguggcuauc gccagccacg auggcggcaa gcaagcgcug     1320

gaaacggugc agcggcuguu gccggugcug ugccaggacc auggccugac cccggaccaa     1380

gugguggcua ucgccagcca cgauggcggc aagcaagcgc ucgaaacggu gcagcggcug     1440

uugccggugc ugugccagga ccauggccug accccggacc aagugguggc uaucgccagc     1500

cacgauggcg gcaagcaagc gcucgaaacg gugcagcggc uguugccggu gcugugccag     1560

gaccauggcc ugaccccgga ccaaguggug gcuaucgcca gcaacaaugg cggcaagcaa     1620

gcgcucgaaa gcauuguggc ccagcugagc cggccugauc cggcguuggc cgcguugacc     1680

aacgaccacc ucgucgccuu ggccugccuc ggcggacguc cugccaugga ugcagugaaa     1740

aagggauugc cgcacgcgcc ggaauugauc agaagaguca aucgccguau uggcgaacgc     1800

acgucccauc gcguugcgau aucuagagug ggaggaagcu ccaucaaccc auggauucug     1860

acugguuucg cugaugccga aggaacuuuc uugcuacgua uccguaaccg uaacagacgu     1920

aucgccaggu acgagacugg ucuggaauuc aagaucaguc ugcacaacaa ggacaaaucg     1980

auucuggaga auauccaguc gacuuggaag gucggcaaga ucaauaacag uggcgaccgu     2040

uaugucacuc ugagagucac gcguuucgaa gauuugaaag ugauuaucga ccacuucgag     2100

aaauauccgc ugauuaccca gaaauugggc gauuacaugu uguuuaaaca ggcauucagc     2160

cucauggaga acaaagaaca ucuuaaggag aaugggauua aggagcucgu acgaaucaga     2220

gcuaagauga auuggggucu caaugacgaa uugaaaaaag cauuuccaga gaacauuggc     2280

aaagagcgcc cccuuaucaa uaagaacauu ccgaaucuca aauggcuggc uggauucaca     2340

ucuggugacg gccauuucgg cgugauucua aacaagcgua aaacagguac ucauguaacu     2400

gugaggcugg uuuucggcau cucacagcac aucagagaca agaaccugau gaauucauug     2460

auaacauacc uaggcugugg uuauauccua gagaaaauca agucugagag uagauggcuc     2520

gauuucaggg uaacaaaauu cagcgauauu aacaacaaga ucauuccggu auuccgggaa     2580

aauacucuga uuggggucaa acucgaggac uuugaagauu ggugcaaggu ugccaaauug     2640

aucgaagaga agaaacaccu gaccgaaucc gguuuggaug agauuaagaa aaucaagcug     2700

aacaugaaca aaggucgu                                                   2718


<210>  37
<211>  711
<212>  RNA
<213>  Mus musculus

<400>  37
augucugagc caccucgggc ugagaccuuu guauuccugg accuagaagc cacugggcuc       60

ccaaacaugg acccugagau ugcagagaua ucccuuuuug cuguucaccg cucuucccug      120

gagaacccag aacgggauga uucugguucc uuggugcugc cccguguucu ggacaagcuc      180

acacugugca ugugcccgga gcgccccuuu acugccaagg ccagugagau uacugguuug      240

agcagcgaaa gccugaugca cugcgggaag gcugguuuca auggcgcugu gguaaggaca      300

cugcagggcu uccuaagccg ccaggagggc cccaucugcc uuguggccca caauggcuuc      360

gauuaugacu ucccacugcu gugcacggag cuacaacguc ugggugccca ucugccccaa      420

gacacugucu gccuggacac acugccugca uugcggggcc uggaccgugc ucacagccac      480

ggcaccaggg cucaaggccg caaaagcuac agccuggcca gucucuucca ccgcuacuuc      540

caggcugaac ccagugcugc ccauucagca gaaggugaug ugcacacccu gcuucugauc      600

uuccugcauc gugcuccuga gcugcucgcc ugggcagaug agcaggcccg cagcugggcu      660

cauauugagc ccauguacgu gccaccugau gguccaagcc ucgaagccug a               711


<210>  38
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  38

Met Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu 
1               5                   10                  15      


Ala Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu 
            20                  25                  30          


Phe Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser 
        35                  40                  45              


Gly Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met 
    50                  55                  60                  


Cys Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu 
65                  70                  75                  80  


Ser Ser Glu Ser Leu Met His Cys Gly Lys Ala Gly Phe Asn Gly Ala 
                85                  90                  95      


Val Val Arg Thr Leu Gln Gly Phe Leu Ser Arg Gln Glu Gly Pro Ile 
            100                 105                 110         


Cys Leu Val Ala His Asn Gly Phe Asp Tyr Asp Phe Pro Leu Leu Cys 
        115                 120                 125             


Thr Glu Leu Gln Arg Leu Gly Ala His Leu Pro Gln Asp Thr Val Cys 
    130                 135                 140                 


Leu Asp Thr Leu Pro Ala Leu Arg Gly Leu Asp Arg Ala His Ser His 
145                 150                 155                 160 


Gly Thr Arg Ala Gln Gly Arg Lys Ser Tyr Ser Leu Ala Ser Leu Phe 
                165                 170                 175     


His Arg Tyr Phe Gln Ala Glu Pro Ser Ala Ala His Ser Ala Glu Gly 
            180                 185                 190         


Asp Val His Thr Leu Leu Leu Ile Phe Leu His Arg Ala Pro Glu Leu 
        195                 200                 205             


Leu Ala Trp Ala Asp Glu Gln Ala Arg Ser Trp Ala His Ile Glu Pro 
    210                 215                 220                 


Met Tyr Val Pro Pro Asp Gly Pro Ser Leu Glu Ala 
225                 230                 235     


<210>  39
<211>  7206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - exemplary AAV donor repair template polynucleotide

<400>  39
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtgtgg      180

atcacagggg ctcgctctgt aattaaaagg aaaagggttt ttgttgtgtt gttgttgttg      240

ctgtttttga gacaagggtc ttgctctgtc atcatccagg ctggagtgca gtggtgcagt      300

ctcagctcac tgcaacctcc gcctcctggg ttcaagcgat tctcctgcct cagcctcctg      360

agcagctagg actacaggtg tgtgccacca tgcctggcta atttttgtat tttttagtgg      420

aaatggggtt ttgccatgtt gcccaggctc gtcttgaact cctgacctca agtgatccac      480

tcgtctcggc ctcccaaagt gctgggatta caggtgtgag ctattgtccc cagccaaaag      540

gaaaagtttt actgtagtaa cccttccgga ctagggacct cgggcctcag cctcaggcta      600

cctaggtgct ttagaaagga ggccacccag gcccatgact actccttgcc acagggagcc      660

ctgcacacag atgtgctaag ctctcgctgc cagccagagg gaggagggtc tgagccagtc      720

agaaggagat gggccccaga gagtaagaaa gggggaggag gacccaagct gatccaaaag      780

gtgggtctaa gcagtcaagt ggaggagggt tccaatctga tggcggaggg cccaagctca      840

gcctaacgag gaggccaggc ccaccaaggg gcccctggag gacttgtttc ccttgtccct      900

tgtggttttt tgcatttcct gttcccttgc tgctcattgc ggaagttcct cttcttaccc      960

tgcacccaga gcctcgccag agaagacaag ggcagaaagc accatgagtg ggggcccaat     1020

gggaggaagg cccgggggcc gaggagcacc agcggttcag cagaacatac cctccaccct     1080

cctccaggac cacgagaacc agcgactctt tgagatgctt ggacgaaaat gcttggtgag     1140

ctggggatct cctgcccccg ccccgtcccc accgttgaac agagaaacag gagaatatgg     1200

gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa gaacagttgg     1260

aacagcagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg     1320

gccaagaaca gatggtcccc agatgcggtc ccgccctcag cagtttctag agaaccatca     1380

gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg aactaaccaa     1440

tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat ataagcagag     1500

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacttccata     1560

gaaggatctc gaggccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc     1620

catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg     1680

cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct     1740

gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg     1800

ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt     1860

ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa     1920

gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga     1980

cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat     2040

ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga     2100

cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt     2160

gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga     2220

gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat     2280

ggacgagctg tacaagtaaa ctagtgtcga ctgctttatt tgtgaaattt gtgatgctat     2340

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     2400

ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaatcttcc tcttcctctc     2460

ctccttctct ctcttcccct cctcccgctc ctcctttccc tctccatcat ctcctctcct     2520

agaatttccc gtcataatcc acccttccca ggaagatctc aatgtctact tgccttccct     2580

ctggctgcag ctcttccttt gggcccatga ctgtcatgag gcaggaagga ccaggtctgg     2640

ctccaagacc ttgtggctac ccctgaccag actccactga cccctgcttt cctctcccag     2700

acgctggcca ctgcagttgt tcagctgtac ctggcgctgc cccctggagc tgagcactgg     2760

accaaggagc attgtggggc tgtgtgcttc gtgaaggata acccccagaa gtcctacttc     2820

atccgccttt acggccttca ggtgaccccc ccacccccga ctggacttgc aagccagttc     2880

tcaacccgca aacccagatc tgtgtccata tgtgtccata gcttcaagac ctcagacctg     2940

atcagtgaat ccctgagccc cagaaccaaa gactcatcca gatggcaaac tctgacttgc     3000

ctttctaagt ctgcaatgac tggccccagt ctccgtatca agatctctaa agcccccagt     3060

attagtctgc tgcctaagcc taatcttttc cacaaattcc aataaatgag cactgtattt     3120

gtacctgaac ctcaaatcta ttctaaactc aacattttgc atcccaggaa tctctcatca     3180

aaactcctga accccagatg tttgccaagc tcctaagtca taaatctgtt caacaaaccc     3240

caaagttgaa tattccattg atccttgaac tccaaatctg tccttctaaa tccacagcac     3300

agaccccaga gttcccatat taaaattcct gaacactcaa ataccgaggt agttcttaag     3360

caaaaagtct tttccacaat cccctgacct gaactttcta ggtttaagcc ccaaattcat     3420

ccttttaaac ccataaagat ggactctaga gtagataagt agcatggcgg gttaatcatt     3480

aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     3540

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     3600

agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca     3660

acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg     3720

ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta     3780

ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac     3840

tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta     3900

aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt     3960

tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg     4020

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct     4080

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat     4140

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt     4200

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg     4260

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac     4320

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta     4380

aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca     4440

atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg     4500

gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc     4560

agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct     4620

ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct     4680

ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa     4740

tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag     4800

tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat     4860

tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct     4920

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     4980

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc     5040

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     5100

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa     5160

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac     5220

gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat     5280

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg     5340

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc     5400

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga     5460

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga     5520

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg     5580

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc     5640

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac     5700

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact     5760

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca     5820

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg     5880

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact     5940

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg     6000

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg     6060

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat     6120

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc     6180

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat     6240

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt     6300

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     6360

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     6420

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     6480

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt     6540

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     6600

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     6660

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     6720

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     6780

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     6840

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     6900

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     6960

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     7020

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     7080

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     7140

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     7200

ttaatg                                                                7206


<210>  40
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Gly Gly Pro Met Gly Gly Arg Pro Gly Gly Arg Gly Ala Pro 
1               5                   10                  15      


Ala Val Gln Gln Asn Ile Pro Ser Thr Leu Leu Gln Asp His Glu Asn 
            20                  25                  30          


Gln Arg Leu Phe Glu Met Leu Gly Arg Lys Cys Leu Thr Leu Ala Thr 
        35                  40                  45              


Ala Val Val Gln Leu Tyr Leu Ala Leu Pro Pro Gly Ala Glu His Trp 
    50                  55                  60                  


Thr Lys Glu His Cys Gly Ala Val Cys Phe Val Lys Asp Asn Pro Gln 
65                  70                  75                  80  


Lys Ser Tyr Phe Ile Arg Leu Tyr Gly Leu Gln Ala Gly Arg Leu Leu 
                85                  90                  95      


Trp Glu Gln Glu Leu Tyr Ser Gln Leu Val Tyr Ser Thr Pro Thr Pro 
            100                 105                 110         


Phe Phe His Thr Phe Ala Gly Asp Asp Cys Gln Ala Gly Leu Asn Phe 
        115                 120                 125             


Ala Asp Glu Asp Glu Ala Gln Ala Phe Arg Ala Leu Val Gln Glu Lys 
    130                 135                 140                 


Ile Gln Lys Arg Asn Gln Arg Gln Ser Gly Asp Arg Arg Gln Leu Pro 
145                 150                 155                 160 


Pro Pro Pro Thr Pro Ala Asn Glu Glu Arg Arg Gly Gly Leu Pro Pro 
                165                 170                 175     


Leu Pro Leu His Pro Gly Gly Asp Gln Gly Gly Pro Pro Val Gly Pro 
            180                 185                 190         


Leu Ser Leu Gly Leu Ala Thr Val Asp Ile Gln Asn Pro Asp Ile Thr 
        195                 200                 205             


Ser Ser Arg Tyr Arg Gly Leu Pro Ala Pro Gly Pro Ser Pro Ala Asp 
    210                 215                 220                 


Lys Lys Arg Ser Gly Lys Lys Lys Ile Ser Lys Ala Asp Ile Gly Ala 
225                 230                 235                 240 


Pro Ser Gly Phe Lys His Val Ser His Val Gly Trp Asp Pro Gln Asn 
                245                 250                 255     


Gly Phe Asp Val Asn Asn Leu Asp Pro Asp Leu Arg Ser Leu Phe Ser 
            260                 265                 270         


Arg Ala Gly Ile Ser Glu Ala Gln Leu Thr Asp Ala Glu Thr Ser Lys 
        275                 280                 285             


Leu Ile Tyr Asp Phe Ile Glu Asp Gln Gly Gly Leu Glu Ala Val Arg 
    290                 295                 300                 


Gln Glu Met Arg Arg Gln Glu Pro Leu Pro Pro Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Arg Gly Gly Asn Gln Leu Pro Arg Pro Pro Ile Val Gly Gly Asn Lys 
                325                 330                 335     


Gly Arg Ser Gly Pro Leu Pro Pro Val Pro Leu Gly Ile Ala Pro Pro 
            340                 345                 350         


Pro Pro Thr Pro Arg Gly Pro Pro Pro Pro Gly Arg Gly Gly Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Ala Thr Gly Arg Ser Gly Pro Leu Pro Pro Pro 
    370                 375                 380                 


Pro Pro Gly Ala Gly Gly Pro Pro Met Pro Pro Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Ser Ser Gly Asn Gly Pro Ala Pro Pro Pro Leu Pro 
                405                 410                 415     


Pro Ala Leu Val Pro Ala Gly Gly Leu Ala Pro Gly Gly Gly Arg Gly 
            420                 425                 430         


Ala Leu Leu Asp Gln Ile Arg Gln Gly Ile Gln Leu Asn Lys Thr Pro 
        435                 440                 445             


Gly Ala Pro Glu Ser Ser Ala Leu Gln Pro Pro Pro Gln Ser Ser Glu 
    450                 455                 460                 


Gly Leu Val Gly Ala Leu Met His Val Met Gln Lys Arg Ser Arg Ala 
465                 470                 475                 480 


Ile His Ser Ser Asp Glu Gly Glu Asp Gln Ala Gly Asp Glu Asp Glu 
                485                 490                 495     


Asp Asp Glu Trp Asp Asp 
            500         


<210>  41
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  41
tctcctagaa tttcccgtca taatccaccc ttcccaggaa gatctcaatg tcta             54


<210>  42
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  42
ggtatgttct gctgaaccgc tgg                                               23


<210>  43
<211>  4616
<212>  DNA
<213>  Artificial Sequene

<220>
<223>  Made in lab - exemplary AAV donor repair template polynucleotide

<400>  43
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtatgg      180

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg      240

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca      300

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg      360

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc      420

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca      480

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga      540

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc      600

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca      660

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc      720

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc      780

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc      840

tggagttcgt gtgatctaga gtagataagt agcatggcgg gttaatcatt aactacaagg      900

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg      960

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     1020

cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc     1080

agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg ttctggatat     1140

taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta ttactaatca     1200

aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac tcggtggcct     1260

cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta aaatcccttt     1320

aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt tatacgtgct     1380

cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     1440

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     1500

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     1560

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg     1620

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     1680

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     1740

tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc     1800

tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca atttaaatat     1860

ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg gtacatatga     1920

ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc agactctcag     1980

gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct ccggcatgaa     2040

tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct ccggcctttc     2100

tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa tatatgaggg     2160

ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag tattacaggg     2220

tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat tgcttaattt     2280

tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct gatgcggtat     2340

tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc     2400

tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc     2460

tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc     2520

tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg     2580

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc     2640

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     2700

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     2760

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     2820

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     2880

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     2940

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     3000

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     3060

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     3120

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     3180

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     3240

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     3300

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     3360

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     3420

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     3480

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     3540

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     3600

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     3660

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     3720

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     3780

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     3840

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     3900

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     3960

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     4020

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     4080

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     4140

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     4200

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     4260

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     4320

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     4380

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     4440

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     4500

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     4560

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatg         4616


<210>  44
<211>  9107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - exemplary reporter vector with WAS megaTAL 
       polynucleotide

<400>  44
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacctgaa agcgaaaggg aaaccagagc tctctcgacg caggactcgg      480

cttgctgaag cgcgcacggc aagaggcgag gggcggcgac tggtgagtac gccaaaaatt      540

ttgactagcg gaggctagaa ggagagagat gggtgcgaga gcgtcagtat taagcggggg      600

agaattagat cgcgatggga aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa      660

ttaaaacata tagtatgggc aagcagggag ctagaacgat tcgcagttaa tcctggcctg      720

ttagaaacat cagaaggctg tagacaaata ctgggacagc tacaaccatc ccttcagaca      780

ggatcagaag aacttagatc attatataat acagtagcaa ccctctattg tgtgcatcaa      840

aggatagaga taaaagacac caaggaagct ttagacaaga tagaggaaga gcaaaacaaa      900

agtaagacca ccgcacagca agcggccgct gatcttcaga cctggaggag gagatatgag      960

ggacaattgg agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt     1020

agcacccacc aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg     1080

agctttgttc cttgggttct tgggagcagc aggaagcact atgggcgcag cctcaatgac     1140

gctgacggta caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct     1200

gagggctatt gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct     1260

ccaggcaaga atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg     1320

gggttgctct ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa     1380

taaatctctg gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa     1440

caattacaca agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa     1500

tgaacaagaa ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac     1560

aaattggctg tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag     1620

aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc     1680

gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa tagaagaaga     1740

aggtggagag agagacagag acagatccat tcgattagtg aacggatctc gacggtatcg     1800

gttaactttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa gaatagtaga     1860

cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa aaattcaaaa     1920

ttttatcgat tacgcgtcac gtgctagctg cagtaacgcc attttgcaag gcatggaaaa     1980

ataccaaacc aagaatagag aagttcagat caagggcggg tacatgaaaa tagctaacgt     2040

tgggccaaac aggatatctg cggtgagcag tttcggcccc ggcccggggc caagaacaga     2100

tggtcaccgc agtttcggcc ccggcccgag gccaagaaca gatggtcccc agatatggcc     2160

caaccctcag cagtttctta agacccatca gatgtttcca ggctccccca aggacctgaa     2220

atgaccctgc gccttatttg aattaaccaa tcagcctgct tctcgcttct gttcgcgcgc     2280

ttctgcttcc cgagctctat aaaagagctc acaacccctc actcggcgcg ccagtcctcc     2340

gacagactga gtcgcccgga tcgatcctcg agcgccacca tggtgagcaa gggcgaggag     2400

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     2460

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     2520

atctgcacca ccggcaacct gcatctcctg cccccgcccc gtccccaccg tttcttcctc     2580

ttcggtatgt tctgctgaac cgctggtctc ctagaatttc ccgtcataat ccacccttcc     2640

caggaagatc tcaatgtcta cctagtgtga accctgacct acggcgtgca gtgcttcagc     2700

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac     2760

gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg     2820

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag     2880

gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc     2940

atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag     3000

gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc     3060

gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac     3120

gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc     3180

atggacgagc tgtacaagta aggccggcca gccacggctt cccccctgag gtggccgctc     3240

aggacgatgg caccctgccc atgagctgcg cccaggagag cggcatggac aggcaccccg     3300

ccgcttgcgc cagcgctagg atcaacgtgg gtgagggcag aggaagtctt ctaacatgcg     3360

gtgacgtgga ggagaatccg ggccctgtga gcaagggcga ggaggataac tccgccatca     3420

tcaaggagtt cctgcgcttc aaggtgcaca tggagggctc cgtgaacggc cacgagttcg     3480

agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc aagctgaagg     3540

tgaccaaggg tggccccctg cccttcgcct gggacatcct gtcccctcag ttcatgtacg     3600

gctccaaggc ctacgtgaag caccccgccg acatccccga ctacttgaag ctgtccttcc     3660

ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga     3720

cccaggactc ctctctgcag gacggcgagt tcatctacaa ggtgaagctg cgcggcacca     3780

acttcccctc cgacggcccc gtaatgcaga agaagaccat gggctgggag gcctcctccg     3840

agcggatgta ccccgaggac ggcgccctga agggcgagat caagcagagg ctgaagctga     3900

aggacggcgg ccactacgac gctgaggtca agaccaccta caaggccaag aagcccgtgc     3960

agctgcccgg cgcctacaac gtcaacatca agttggacat cacctcccac aacgaggact     4020

acaccatcgt ggaacagtac gaacgcgccg agggccgcca ctccaccggc ggcatggacg     4080

agctgtacaa gtgaatgcat aggctccggt gcccgtcagt gggcagagcg cacatcgccc     4140

acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg     4200

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     4260

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     4320

gccagaacac aggatcctcg agccaccatg accgagtaca agcccacggt gcgcctcgcc     4380

acccgcgacg acgtcccccg ggccgtacgc accctcgccg ccgcgttcgc cgactacccc     4440

gccacgcgcc acaccgtcga cccggaccgc cacatcgagc gggtcaccga gctgcaagaa     4500

ctcttcctca cgcgcgtcgg gctcgacatc ggcaaggtgt gggtcgcgga cgacggcgcc     4560

gcggtggcgg tctggaccac gccggagagc gtcgaagcgg gggcggtgtt cgccgagatc     4620

ggcccgcgca tggccgagtt gagcggttcc cggctggccg cgcagcaaca gatggaaggc     4680

ctcctggcgc cgcaccggcc caaggagccc gcgtggttcc tggccaccgt cggcgtctcg     4740

cccgaccacc agggcaaggg tctgggcagc gccgtcgtgc tccccggagt ggaggcggcc     4800

gagcgcgccg gggtgcccgc cttcctggag acctccgcgc cccgcaacct ccccttctac     4860

gagcggctcg gcttcaccgt caccgccgac gtcgaggtgc ccgaaggacc gcgcacctgg     4920

tgcatgaccc gcaagcccgg tgcctgaatc tagtgtcgac aatcaacctc tggattacaa     4980

aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata     5040

cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc     5100

cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg     5160

tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac     5220

ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat     5280

cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt     5340

ggtgttgtcg gggaagctga cgtcctttcc atggctgctc gcctgtgttg ccacctggat     5400

tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc     5460

ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag     5520

tcggatctcc ctttgggccg cctccccgcc tggaattcga gctcggtacc tttaagacca     5580

atgacttaca aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa     5640

gggctaattc actcccaacg aagacaagat ctgctttttg cttgtactgg gtctctctgg     5700

ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct     5760

caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt     5820

aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tagtagttca     5880

tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga gagtgagagg     5940

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     6000

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct     6060

tatcatgtct ggctctagct atcccgcccc taactccgcc cagttccgcc cattctccgc     6120

cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc     6180

tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcgtc gagacgtacc     6240

caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg     6300

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     6360

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     6420

gaatggcgaa tggcgcgacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     6480

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     6540

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     6600

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     6660

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     6720

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     6780

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     6840

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa tttcccaggt     6900

ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca     6960

aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg     7020

aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc     7080

cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg     7140

ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt     7200

cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta     7260

ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat     7320

gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga     7380

gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca     7440

acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact     7500

cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc     7560

acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact     7620

ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt     7680

ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt     7740

gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt     7800

atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata     7860

ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag     7920

attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat     7980

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     8040

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     8100

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     8160

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg     8220

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     8280

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     8340

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     8400

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     8460

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     8520

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     8580

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     8640

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     8700

cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag     8760

tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa     8820

gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc     8880

agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg     8940

agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg     9000

tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc     9060

aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgca                   9107


<210>  45
<211>  7013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - exemplary AAV donor repair template polynucleotide

<400>  45
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtaggc      180

tcgtcttgaa ctcctgacct caagtgatcc actcgtctcg gcctcccaaa gtgctgggat      240

tacaggtgtg agctattgtc cccagccaaa aggaaaagtt ttactgtagt aacccttccg      300

gactagggac ctcgggcctc agcctcaggc tacctaggtg ctttagaaag gaggccaccc      360

aggcccatga ctactccttg ccacagggag ccctgcacac agatgtgcta agctctcgct      420

gccagccaga gggaggaggg tctgagccag tcagaaggag atgggcccca gagagtaaga      480

aagggggagg aggacccaag ctgatccaaa aggtgggtct aagcagtcaa gtggaggagg      540

gttccaatct gatggcggag ggcccaagct cagcctaacg aggaggccag gcccaccaag      600

gggcccctgg aggacttgtt tcccttgtcc cttgtggttt tttgcatttc ctgttccctt      660

gctgctcatt gcggaagttc ctcttcttac cctgcaccca gagcctcgcc agagaagaca      720

agggcagaaa gcaccatgag tgggggccca atgggaggaa gacccggcgg ccgaggagcg      780

ccagcagtgc aacaaaacat tccgtcaacc ctgctgcagg accacgaaaa ccagaggctg      840

tttgaaatgt tgggacggaa gtgtctcact ctcgccacag ccgtcgtcca gctttatctt      900

gcgcttcctc ccggtgctga gcattggact aaagagcatt gcggcgcggt ctgttttgtc      960

aaggataatc cccaaaaatc atatttcatt aggttgtacg gactccaagc tggacgcctt     1020

ctgtgggaac aagaactcta tagccagctc gtatatagca caccgacccc tttcttccat     1080

actttcgcgg gagacgactg tcaggcgggc ttgaactttg cggacgagga tgaagctcag     1140

gctttccgag cattggttca agaaaaaatc cagaaaagaa atcagcgaca gtccggagat     1200

cgccggcagc tgccgccgcc acctacaccg gccaatgagg aacggagggg aggccttccg     1260

ccacttccat tgcatccagg cggcgatcag ggtgggccac cagtagggcc cttgagtttg     1320

ggtctcgcta ctgtggatat acagaacccg gacataacat ctagccgcta ccgcggactg     1380

ccggctccag gtccgtcccc cgctgataaa aagcgctccg gcaaaaagaa gatatctaaa     1440

gcagatatcg gtgcgccctc cggtttcaag catgtctccc atgtaggatg ggacccgcaa     1500

aatggattcg acgttaataa cctcgatccg gacctgagga gtctcttctc tcgcgcgggt     1560

atcagcgagg cacagcttac tgatgccgaa acaagtaagt tgatatacga ctttatcgag     1620

gatcaaggag ggctggaagc ggtcaggcaa gaaatgcggc gacaagaacc tttgcccccg     1680

cccccgcccc cgtccagagg cgggaaccag cttccacgcc cacctatcgt tggagggaat     1740

aaaggcaggt ctgggccact ccctccggta ccgttgggga tcgctccacc gcctcctacg     1800

cctaggggac ccccgcctcc tggtcggggg ggaccgcccc ctccgccgcc tccagccact     1860

ggtcgaagtg gacccctccc gcctcctcca cccggcgccg ggggcccacc gatgccacct     1920

cctcctccgc ccccaccgcc tcccccttct tccggcaacg gtcccgcacc tccgcccctc     1980

cctccggcat tggtccccgc ggggggcctc gcgcctggtg gtggccgggg tgcacttctg     2040

gatcaaatcc gacagggcat acagttgaat aagacgcccg gcgcccctga aagctcagct     2100

ctgcaaccgc cgcctcagtc ctctgaaggg ttggtaggcg cgctcatgca tgtaatgcag     2160

aagcgcagtc gcgctatcca ctcatcagat gaaggtgaag accaggccgg tgacgaggac     2220

gaagacgatg aatgggacga ttgactgaac tgaactagtg tcgacgataa tcaacctctg     2280

gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta     2340

tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt     2400

ttctcctcct tgtataaatc ctggttagtt cttgccacgg cggaactcat cgccgcctgc     2460

cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt gggtcgactg     2520

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     2580

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     2640

ggttttttaa atcttcctct tcctctcctc cttctctctc ttcccctcct cccgctcctc     2700

ctttccctct ccatcatctc ctctcctaga atttcccgtc ataatccacc cttcccagga     2760

agatctcaat gtctacttgc cttccctctg gctgcagctc ttcctttggg cccatgactg     2820

tcatgaggca ggaaggacca ggtctggctc caagaccttg tggctacccc tgaccagact     2880

ccactgaccc ctgctttcct ctcccagacg ctggccactg cagttgttca gctgtacctg     2940

gcgctgcccc ctggagctga gcactggacc aaggagcatt gtggggctgt gtgcttcgtg     3000

aaggataacc cccagaagtc ctacttcatc cgcctttacg gccttcaggt gaccccccca     3060

cccccgactg gacttgcaag ccagttctca acccgcaaac ccagatctgt gtccatatgt     3120

gtccatagct tcaagacctc agacctgatc agtgaatccc tgagccccag aaccaaagac     3180

tcatccagat ggcaaactct gacttgcctt tctaagtctg caatgactgg ccccagtctc     3240

cgtatcaaga ttctagagta gataagtagc atggcgggtt aatcattaac tacaaggaac     3300

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3360

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3420

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     3480

ctgaatggcg aatggcgatt ccgttgcaat ggctggcggt aatattgttc tggatattac     3540

cagcaaggcc gatagtttga gttcttctac tcaggcaagt gatgttatta ctaatcaaag     3600

aagtattgcg acaacggtta atttgcgtga tggacagact cttttactcg gtggcctcac     3660

tgattataaa aacacttctc aggattctgg cgtaccgttc ctgtctaaaa tccctttaat     3720

cggcctcctg tttagctccc gctctgattc taacgaggaa agcacgttat acgtgctcgt     3780

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     3840

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     3900

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     3960

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     4020

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     4080

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     4140

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     4200

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt taaatatttg     4260

cttatacaat cttcctgttt ttggggcttt tctgattatc aaccggggta catatgattg     4320

acatgctagt tttacgatta ccgttcatcg attctcttgt ttgctccaga ctctcaggca     4380

atgacctgat agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt     4440

atcagctaga acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca     4500

cccgtttgaa tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc     4560

taaaaatttt tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca     4620

taatgttttt ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc     4680

taattctttg ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt     4740

ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc     4800

tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga     4860

cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc     4920

atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata     4980

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     5040

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     5100

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     5160

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     5220

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     5280

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     5340

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     5400

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     5460

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     5520

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     5580

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     5640

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     5700

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     5760

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     5820

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     5880

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     5940

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     6000

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     6060

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     6120

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     6180

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     6240

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     6300

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     6360

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     6420

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     6480

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     6540

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     6600

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     6660

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     6720

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     6780

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     6840

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     6900

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     6960

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atg            7013


<210>  46
<211>  6992
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - exemplary AAV donor repair template polynucleotide

<400>  46
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtaggc      180

tcgtcttgaa ctcctgacct caagtgatcc actcgtctcg gcctcccaaa gtgctgggat      240

tacaggtgtg agctattgtc cccagccaaa aggaaaagtt ttactgtagt aacccttccg      300

gactagggac ctcgggcctc agcctcaggc tacctaggtg ctttagaaag gaggccaccc      360

aggcccatga ctactccttg ccacagggag ccctgcacac agatgtgcta agctctcgct      420

gccagccaga gggaggaggg tctgagccag tcagaaggag atgggcccca gagagtaaga      480

aagggggagg aggacccaag ctgatccaaa aggtgggtct aagcagtcaa gtggaggagg      540

gttccaatct gatggcggag ggcccaagct cagcctaacg aggaggccag gcccaccaag      600

gggcccctgg aggacttgtt tcccttgtcc cttgtggttt tttgcatttc ctgttccctt      660

gctgctcatt gcggaagttc ctcttcttac cctgcaccca gagcctcgcc agagaagaca      720

agggcagaaa gcaccatgag tgggggccca atgggaggaa ggcccggggg ccgaggagca      780

ccagcggttc agcagaacat accctccacc ctcctccagg accacgagaa ccagcgactc      840

tttgagatgc ttggacgaaa atgcttgacg ctggccactg cagttgttca gctgtacctg      900

gcgctgcccc ctggagctga gcactggacc aaggagcatt gtggggctgt gtgcttcgtg      960

aaggataacc cccagaagtc ctacttcatc cgcctttacg gccttcaggc tggtcggctg     1020

ctctgggaac aggagctgta ctcacagctt gtctactcca cccccacccc cttcttccac     1080

accttcgctg gagatgactg ccaagcgggg ctgaactttg cagacgagga cgaggcccag     1140

gccttccggg ccctcgtgca ggagaagata caaaaaagga atcagaggca aagtggagac     1200

agacgccagc tacccccacc accaacacca gccaatgaag agagaagagg agggctccca     1260

cccctgcccc tgcatccagg tggagaccaa ggaggccctc cagtgggtcc gctctccctg     1320

gggctggcga cagtggacat ccagaaccct gacatcacga gttcacgata ccgtgggctc     1380

ccagcacctg gacctagccc agctgataag aaacgctcag ggaagaagaa gatcagcaaa     1440

gctgatattg gtgcacccag tggattcaag catgtcagcc acgtggggtg ggacccccag     1500

aatggatttg acgtgaacaa cctcgaccca gatctgcgga gtctgttctc cagggcagga     1560

atcagcgagg cccagctcac cgacgccgag acctctaaac ttatctacga cttcattgag     1620

gaccagggtg ggctggaggc tgtgcggcag gagatgaggc gccaggagcc acttccgccg     1680

cccccaccgc catctcgagg agggaaccag ctcccccggc cccctattgt ggggggtaac     1740

aagggtcgtt ctggtccact gccccctgta cctttgggga ttgccccacc cccaccaaca     1800

ccccggggac ccccaccccc aggccgaggg ggccctccac caccaccccc tccagctact     1860

ggacgttctg gaccactgcc ccctccaccc cctggagctg gtgggccacc catgccacca     1920

ccaccgccac caccgccacc gccgcccagc tccgggaatg gaccagcccc tcccccactc     1980

cctcctgctc tggtgcctgc cgggggcctg gcccctggtg ggggtcgggg agcgcttttg     2040

gatcaaatcc ggcagggaat tcagctgaac aagacccctg gggccccaga gagctcagcg     2100

ctgcagccac cacctcagag ctcagaggga ctggtggggg ccctgatgca cgtgatgcag     2160

aagagaagca gagccatcca ctcctccgac gaaggggagg accaggctgg cgatgaagat     2220

gaagatgatg aatgggatga ctgagataat caacctctgg attacaaaat ttgtgaaaga     2280

ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg     2340

cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc     2400

tggttagttc ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg     2460

gctcggctgt tgggcactga caattccgtg ggtcgactgc tttatttgtg aaatttgtga     2520

tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg     2580

cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa tcttcctctt     2640

cctctcctcc ttctctctct tcccctcctc ccgctcctcc tttccctctc catcatctcc     2700

tctcctagaa tttcccgtca taatccaccc ttcccaggaa gatctcaatg tctacttgcc     2760

ttccctctgg ctgcagctct tcctttgggc ccatgactgt catgaggcag gaaggaccag     2820

gtctggctcc aagaccttgt ggctacccct gaccagactc cactgacccc tgctttcctc     2880

tcccagacgc tggccactgc agttgttcag ctgtacctgg cgctgccccc tggagctgag     2940

cactggacca aggagcattg tggggctgtg tgcttcgtga aggataaccc ccagaagtcc     3000

tacttcatcc gcctttacgg ccttcaggtg acccccccac ccccgactgg acttgcaagc     3060

cagttctcaa cccgcaaacc cagatctgtg tccatatgtg tccatagctt caagacctca     3120

gacctgatca gtgaatccct gagccccaga accaaagact catccagatg gcaaactctg     3180

acttgccttt ctaagtctgc aatgactggc cccagtctcc gtatcaagat tctagagtag     3240

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca     3300

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     3360

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg ccagctggcg taatagcgaa     3420

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgattc     3480

cgttgcaatg gctggcggta atattgttct ggatattacc agcaaggccg atagtttgag     3540

ttcttctact caggcaagtg atgttattac taatcaaaga agtattgcga caacggttaa     3600

tttgcgtgat ggacagactc ttttactcgg tggcctcact gattataaaa acacttctca     3660

ggattctggc gtaccgttcc tgtctaaaat ccctttaatc ggcctcctgt ttagctcccg     3720

ctctgattct aacgaggaaa gcacgttata cgtgctcgtc aaagcaacca tagtacgcgc     3780

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     3840

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     3900

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     3960

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     4020

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     4080

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     4140

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     4200

attttaacaa aatattaacg tttacaattt aaatatttgc ttatacaatc ttcctgtttt     4260

tggggctttt ctgattatca accggggtac atatgattga catgctagtt ttacgattac     4320

cgttcatcga ttctcttgtt tgctccagac tctcaggcaa tgacctgata gcctttgtag     4380

agacctctca aaaatagcta ccctctccgg catgaattta tcagctagaa cggttgaata     4440

tcatattgat ggtgatttga ctgtctccgg cctttctcac ccgtttgaat ctttacctac     4500

acattactca ggcattgcat ttaaaatata tgagggttct aaaaattttt atccttgcgt     4560

tgaaataaag gcttctcccg caaaagtatt acagggtcat aatgtttttg gtacaaccga     4620

tttagcttta tgctctgagg ctttattgct taattttgct aattctttgc cttgcctgta     4680

tgatttattg gatgttggaa tcgcctgatg cggtattttc tccttacgca tctgtgcggt     4740

atttcacacc gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     4800

cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca     4860

tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg     4920

tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat     4980

gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga     5040

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     5100

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt     5160

gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg     5220

ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg     5280

gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg     5340

agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag     5400

caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca     5460

gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg     5520

agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc     5580

gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg     5640

aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg     5700

ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac     5760

tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg     5820

tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg     5880

gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact     5940

atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa     6000

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     6060

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     6120

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     6180

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     6240

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     6300

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     6360

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     6420

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     6480

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     6540

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     6600

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     6660

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     6720

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     6780

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     6840

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     6900

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg     6960

cctctccccg cgcgttggcc gattcattaa tg                                   6992


<210>  47
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  47
tctcctgccc ccgccccgtc cccaccgttt cttcctcttc                             40


<210>  48
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  48

Gly Gly Gly 
1           


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  49

Asp Gly Gly Gly Ser 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  50

Thr Gly Glu Lys Pro 
1               5   


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  51

Gly Gly Arg Arg 
1               


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  52

Gly Gly Gly Gly Ser 
1               5   


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  53

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  54

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  55

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  56

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  57

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  58

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  59

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  60

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  61

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  62
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  62

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  63
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  63

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  64

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  65

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  66

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  67

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  68
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  68

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  69

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  70

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  71
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  71

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  72
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  72

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  73

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  74

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  75
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  75

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  76

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  77

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  78

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  79
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  79

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  80
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  80

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  81
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  81

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  82
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  82

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  83
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  83

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  84
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  84
gccrccatgg                                                              10


