                         SEQUENCE LISTING

<110>  Children's Medical Center Corporation
 
<120>  PAPD5 INHIBITORS AND METHODS OF USE THEREOF

<130>  37314-0083WO1

<140>  PCT/US2020/029593
<141>  2020-04-23

<150>  US 62/838,221
<151>  2019-04-24

<150>  US 62/952,775
<151>  2019-12-23

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  631
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  1

Met Tyr Arg Ser Gly Glu Arg Leu Leu Gly Ser His Ala Leu Pro Ala 
1               5                   10                  15      


Glu Gln Arg Asp Phe Leu Pro Leu Glu Thr Thr Asn Asn Asn Asn Asn 
            20                  25                  30          


His His Gln Pro Gly Ala Trp Ala Arg Arg Ala Gly Ser Ser Ala Ser 
        35                  40                  45              


Ser Pro Pro Ser Ala Ser Ser Ser Pro His Pro Ser Ala Ala Val Pro 
    50                  55                  60                  


Ala Ala Asp Pro Ala Asp Ser Ala Ser Gly Ser Ser Asn Lys Arg Lys 
65                  70                  75                  80  


Arg Asp Asn Lys Ala Ser Thr Tyr Gly Leu Asn Tyr Ser Leu Leu Gln 
                85                  90                  95      


Pro Ser Gly Gly Arg Ala Ala Gly Gly Gly Arg Ala Asp Gly Gly Gly 
            100                 105                 110         


Val Val Tyr Ser Gly Thr Pro Trp Lys Arg Arg Asn Tyr Asn Gln Gly 
        115                 120                 125             


Val Val Gly Leu His Glu Glu Ile Ser Asp Phe Tyr Glu Tyr Met Ser 
    130                 135                 140                 


Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val Val Asn Arg Ile 
145                 150                 155                 160 


Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp Val Gln Ile Phe 
                165                 170                 175     


Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp Ile Asp Leu 
            180                 185                 190         


Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr Leu Glu Glu 
        195                 200                 205             


Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val Lys Val Leu 
    210                 215                 220                 


Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser Phe Thr Glu 
225                 230                 235                 240 


Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val Arg Ala Ala 
                245                 250                 255     


Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu Pro Tyr Leu 
            260                 265                 270         


Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu Asn Glu Val 
        275                 280                 285             


Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met Ala Val Ser 
    290                 295                 300                 


Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro Asn Thr Asn 
305                 310                 315                 320 


Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly Arg His Phe 
                325                 330                 335     


Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly Ser Tyr Val 
            340                 345                 350         


Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr Arg Pro Ser 
        355                 360                 365             


Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp Val Gly Arg 
    370                 375                 380                 


Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp Tyr Ala Tyr 
385                 390                 395                 400 


Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr Tyr Pro Asn 
                405                 410                 415     


Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val Thr Asp Glu 
            420                 425                 430         


Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly Leu Lys Asn 
        435                 440                 445             


Arg Pro Glu Pro Ser Cys Asn Gly Asn Gly Val Thr Leu Ile Val Asp 
    450                 455                 460                 


Thr Gln Gln Leu Asp Lys Cys Asn Asn Asn Leu Ser Glu Glu Asn Glu 
465                 470                 475                 480 


Ala Leu Gly Lys Cys Arg Ser Lys Thr Ser Glu Ser Leu Ser Lys His 
                485                 490                 495     


Ser Ser Asn Ser Ser Ser Gly Pro Val Ser Ser Ser Ser Ala Thr Gln 
            500                 505                 510         


Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro Cys Lys Thr Pro 
        515                 520                 525             


Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg Val Gly Ser Gln 
    530                 535                 540                 


Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys Met Gln Ser Thr 
545                 550                 555                 560 


Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser Gln His Gly Ser 
                565                 570                 575     


Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln Gly Thr Thr Gln 
            580                 585                 590         


Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His Gln Gly Lys Ser 
        595                 600                 605             


Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His Lys Arg Asp Ala 
    610                 615                 620                 


Pro Leu Ser Asp Leu Cys Arg 
625                 630     


<210>  2
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  2
ccucuuguug cugcugcccg                                                   20


<210>  3
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  3
cggagcgaua caugccggcc                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  4
ccucuuguug cugcugcccg                                                   20


