                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF

<130>  6923-297-228

<140>
<141>

<150>  US 62/838,251
<151>  2019-04-24

<160>  204

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH

<400>  1

Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Lys Gln Arg Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL

<400>  2

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Cys Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HCDR1 (IMGT)

<400>  3

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HCDR2 (IMGT)

<400>  4

Ile His Pro Gly Ser Thr Asn Thr 
1               5               


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HCDR3 (IMGT)

<400>  5

Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LCDR1 (IMGT)

<400>  6

Gln Asn Val Val Thr Asn 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LCDR2 (IMGT)

<400>  7

Ser Ala Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LCDR3 (IMGT)

<400>  8

Gln Gln Tyr His Ser Tyr Pro Phe Thr 
1               5                   


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR1 (IMGT)

<400>  9

Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR2 (IMGT)

<400>  10

Leu Asn Trp Val Lys Gln Arg Pro Arg Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gln 
    


<210>  11
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR3 (IMGT)

<400>  11

Tyr Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR4 (IMGT)

<400>  12

Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
1               5                   10      


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR1 (IMGT)

<400>  13

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
            20                  25      


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR2 (IMGT)

<400>  14

Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR3 (IMGT)

<400>  15

Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Glu Tyr Cys Cys 
        35      


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR4 (IMGT)

<400>  16

Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
1               5                   10  


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH

<400>  17

Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Asp Phe Asp Ser Glu Val Phe Pro Ile 
            20                  25                  30          


Val Tyr Met Arg Trp Ile Arg Gln Lys Pro Gly His Gly Phe Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Leu Pro Ser Phe Gly Arg Thr Ile Tyr Gly Glu Lys 
    50                  55                  60                  


Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr Val Ser Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp His Gly Asn Trp Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL

<400>  18

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asn Arg Phe Thr Gly 
    50                  55                  60                  


Ile Ile Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 HCDR1 (IMGT)

<400>  19

Asp Ser Glu Val Phe Pro Ile Val Tyr 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 HCDR2 (IMGT)

<400>  20

Ile Leu Pro Ser Phe Gly Arg Thr 
1               5               


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 HCDR3 (IMGT)

<400>  21

Ala Arg Gly Asp His Gly Asn Trp Leu Ala Tyr 
1               5                   10      


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 LCDR1 (IMGT)

<400>  22

Gln Asp Val Ser Thr Ala 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 LCDR2 (IMGT)

<400>  23

Trp Ala Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 LCDR3 (IMGT)

<400>  24

Gln Gln His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR1 (IMGT)

<400>  25

Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Asp Phe 
            20                  25  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR2 (IMGT)

<400>  26

Met Arg Trp Ile Arg Gln Lys Pro Gly His Gly Phe Glu Trp Ile Gly 
1               5                   10                  15      


Asp 
    


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR3 (IMGT)

<400>  27

Ile Tyr Gly Glu Lys Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr 
1               5                   10                  15      


Val Ser Asn Thr Ala Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Ile Tyr Tyr Cys 
        35              


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR4 (IMGT)

<400>  28

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  29
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR1 (IMGT)

<400>  29

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR2 (IMGT)

<400>  30

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  31
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR3 (IMGT)

<400>  31

Thr Arg His Thr Gly Val Pro Asn Arg Phe Thr Gly Ile Ile Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            20                  25                  30          


Leu Tyr Tyr Cys 
        35      


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR4 (IMGT)

<400>  32

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  33
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Cys 
        35                  40                  45              


Gly Glu Ile Phe Pro Gly Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Asp Tyr Tyr Gly Ser Ser Tyr Gly Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL

<400>  34

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Glu Lys Pro Gly Arg Thr Asn Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Ile Leu Ser Phe Gly Asn Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 HCDR1 (IMGT)

<400>  35

Gly Tyr Lys Phe Thr Ser Tyr Trp 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 HCDR2 (IMGT)

<400>  36

Ile Phe Pro Gly Ser Gly Ser Ile 
1               5               


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 HCDR3 (IMGT)

<400>  37

Ala Arg Gly Glu Asp Tyr Tyr Gly Ser Ser Tyr Gly Ala Met Asp Tyr 
1               5                   10                  15      


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 LCDR1 (IMGT)

<400>  38

Lys Ser Ile Ser Lys Tyr 
1               5       


<210>  39
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 LCDR2 (IMGT)

<400>  39

Ser Gly Ser 
1           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 LCDR3 (IMGT)

<400>  40

Gln Gln His Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR1 (IMGT)

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr 
            20                  25  


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR2 (IMGT)

<400>  42

Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Cys Gly 
1               5                   10                  15      


Glu 
    


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR3 (IMGT)

<400>  43

Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asn Thr Ala Tyr Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR4 (IMGT)

<400>  44

Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
1               5                   10      


<210>  45
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR1 (IMGT)

<400>  45

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser 
            20                  25      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR2 (IMGT)

<400>  46

Val Ala Trp Tyr Gln Glu Lys Pro Gly Arg Thr Asn Lys Val Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  47
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR3 (IMGT)

<400>  47

Ile Leu Ser Phe Gly Asn Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Met Tyr Tyr Cys 
        35      


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR4 (IMGT)

<400>  48

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  49
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH

<400>  49

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Ser Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Glu Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL

<400>  50

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile His Thr 
            20                  25                  30          


Asn Gly Asp Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Ala Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 HCDR1 (IMGT)

<400>  51

Gly Phe Thr Phe Thr Asp Tyr Pro 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 HCDR2 (IMGT)

<400>  52

Ile Asn Thr Glu Thr Glu Glu Pro 
1               5               


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 HCDR3 (IMGT)

<400>  53

Ala Arg Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
1               5                   10                  15      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 LCDR1 (IMGT)

<400>  54

Gln Ser Leu Ile His Thr Asn Gly Asp Thr Phe 
1               5                   10      


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 LCDR2 (IMGT)

<400>  55

Lys Val Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 LCDR3 (IMGT)

<400>  56

Ser Gln Ser Ala Leu Phe Pro Tyr Thr 
1               5                   


<210>  57
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR1 (IMGT)

<400>  57

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR2 (IMGT)

<400>  58

Met His Trp Val Lys Gln Ala Pro Gly Lys Ser Leu Lys Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  59
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR3 (IMGT)

<400>  59

Thr Tyr Ser Asp Asp Phe Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Thr Thr Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Phe Cys 
        35              


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR4 (IMGT)

<400>  60

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  61
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR1 (IMGT)

<400>  61

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR2 (IMGT)

<400>  62

Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  63
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR3 (IMGT)

<400>  63

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Ile Tyr Phe Cys 
        35      


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR4 (IMGT)

<400>  64

Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
1               5                   10  


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH

<400>  65

Asp Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Thr Gly Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Thr Arg Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Ile Val Ser Ala 
        115                 120     


<210>  66
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL

<400>  66

Gln Val Val Leu Thr Gln Ser Pro Ala Leu Ile Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Asn Val Asn Tyr Met 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Lys Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Gln Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 HCDR1 (IMGT)

<400>  67

Gly Phe Thr Phe Ser Ala Tyr Ser 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 HCDR2 (IMGT)

<400>  68

Ile Asn Thr Gly Gly Ser Phe Thr 
1               5               


<210>  69
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 HCDR3 (IMGT)

<400>  69

Thr Arg Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr 
1               5                   10                  


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 LCDR1 (IMGT)

<400>  70

Ser Asn Val Asn Tyr 
1               5   


<210>  71
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 LCDR2 (IMGT)

<400>  71

Leu Thr Ser 
1           


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 LCDR3 (IMGT)

<400>  72

Gln Gln Trp Ser Ser Asp Pro Gln Thr 
1               5                   


<210>  73
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR1 (IMGT)

<400>  73

Asp Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR2 (IMGT)

<400>  74

Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  75
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR3 (IMGT)

<400>  75

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Phe Cys 
        35              


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR4 (IMGT)

<400>  76

Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ala 
1               5                   10      


<210>  77
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR1 (IMGT)

<400>  77

Gln Val Val Leu Thr Gln Ser Pro Ala Leu Ile Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR2 (IMGT)

<400>  78

Met Ser Trp Tyr Gln Gln Arg Pro Arg Ser Ser Pro Lys Pro Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  79
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR3 (IMGT)

<400>  79

Lys Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR4 (IMGT)

<400>  80

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  81
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F2 VH

<400>  81
caggttcacc tgcagcagtc tggacctgag gtggcgaggc ccggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcact gactactatc ttaactgggt gaagcagagg      120

cctagacagg gccttgagtg gattggacag attcatcctg gaagtactaa tacttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcagtct atttctgtgc aagatcgctt      300

ggtgatggtt actacgtcta tgctatggac tactggggtc agggaaccgc agtcaccgtc      360

tcctca                                                                 366


<210>  82
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F2 VL

<400>  82
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggtt actaatgtag tctggtatca acagaaacca      120

ggtcagtctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtactg ctgtcagcaa tatcacagct atccattcac gttcggctcg      300

gggacaaagt tggaagtaaa a                                                321


<210>  83
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F4 VH

<400>  83
caggttcacc tacaacagtc tggttctgaa ctgaggagtc ctgggtcttc agtaaagctt       60

tcatgcaagg attttgattc agaagtcttc cctattgttt atatgagatg gattaggcag      120

aagcctggcc atggatttga atggattgga gacatactcc caagttttgg tagaacaatc      180

tatggagaga agtttgagga caaagccaca ctagatgcag acacagtgtc caacacagcc      240

tacttggagc tcaacagtct gacatctgag gactctgcta tctactactg tgcaaggggg      300

gaccatggta actggcttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  84
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F4 VL

<400>  84
gacattgtga tgacccagtc tcacaaattc atgtccacat cagttggaga cagggtcacc       60

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acaaaaacca      120

ggccaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctaat      180

cgcttcacag gcattatatc tgggacagat tacactctca ctatcagcag tgtgcaggct      240

gaagacctgg cactttatta ctgtcagcaa cattatagcg ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  85
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G1 VH

<400>  85
caggttcagc tgcagcagtc tggagctgaa ttgatgaagc ctggggcctc agtgaagatt       60

tcctgcaagg ctactgggta caaattcact agttattgga tagggtgggt aaagcagagg      120

ccgggacatg gccttgagtg gtgtggagag atttttcctg gaagtggcag tattaactat      180

aatgagaaat ttaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

ttgcaactga ccagcctgac atctgaggac tctgccgtct attactgtgc aagaggggag      300

gattattacg gtagtagtta cggtgctatg gactactggg gtcaaggaac ctcactcacc      360

gtctcctca                                                              369


<210>  86
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G1 VL

<400>  86
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcatcagc aaatatgtag cctggtatca agagaaacct      120

gggagaacta acaaggttct tatatattct ggatcaatct tgtcatttgg aaatccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag cataatgaat acccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  87
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B2 VH

<400>  87
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggttt taccttcaca gactatccaa tgcactgggt gaagcaggct      120

ccaggaaaga gtttaaagtg gatgggttgg ataaacactg agactgaaga gccaacatat      180

tcagatgact tcaagggacg gtttgccttg tctttggaaa cctctgccag cacaacctat      240

ttgcagatca acaatctcaa aaatgaggac acggctacat atttctgtgc tagatcaggt      300

tattactatg gtagtaccta cgcctggttt ggttactggg gccaagggac tctggtcact      360

gtctctgca                                                              369


<210>  88
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B2 VL

<400>  88
gatgttgtga tgacccaaat tccactctcc ctgcctgtca gtctcggaga tcaggcctcc       60

atctcttgca gatctagtca gagccttata cacactaatg gagacacctt tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cactggcggt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tatttctgct ctcaaagtgc actttttccg      300

tacacgttcg gaggggggac caacctggaa ataaaa                                336


<210>  89
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4F11 VH

<400>  89
gacgtgaaac tggtggaatc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gcctattcca tgtcttgggt tcgccagact      120

ccggagagga ggctggagtg ggtcgcaacc attaatactg gtggtagttt cacctactat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt atttctgtac aagagtttcc      300

gactacggta atagcgccta ctttccttac tggggccaag ggactctggt cattgtctct      360

gca                                                                    363


<210>  90
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4F11 VL

<400>  90
caagttgttc tcacccagtc tccagcactc atatctgcgt ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aaatgtaaat tacatgtcct ggtaccagca gaggccaaga      120

tcctccccca aaccctggat ttatctcaca tccaaactgg cttctggagt ccctcctcgt      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ccagcagtgg agcagtgacc cccagacgtt cggagggggg      300

accaaggtgg aaataaaa                                                    318


<210>  91
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' consensus anchor primer


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  where n is c, u or a

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  where n is c, u or a

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  where n is c, u or a

<400>  91
ggccacgcgt cgactagtac gggnngggnn gggnng                                 36


<210>  92
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Constant region specific reverse primer IgG2a

<400>  92
ccttgaccag gcatcctaga gtc                                               23


<210>  93
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Constant region specific reverse primer IgG2b

<400>  93
ggaggtgtgc acactgctgg acag                                              24


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR1 (Chothia)

<400>  94

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR2 (Chothia)

<400>  95

His Pro Gly Ser Thr Asn 
1               5       


<210>  96
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR3 (Chothia)

<400>  96

Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR1 (Chothia)

<400>  97

Lys Ala Ser Gln Asn Val Val Thr Asn Val Val 
1               5                   10      


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR2 (Chothia)

<400>  98

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR3 (Chothia)

<400>  99

Gln Gln Tyr His Ser Tyr Pro Phe Thr 
1               5                   


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR1 (ABM)

<400>  100

Gly Tyr Thr Phe Thr Asp Tyr Tyr Leu Asn 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR2 (ABM)

<400>  101

Gln Ile His Pro Gly Ser Thr Asn Thr Tyr 
1               5                   10  


<210>  102
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR3 (ABM)

<400>  102

Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR1 (ABM)

<400>  103

Lys Ala Ser Gln Asn Val Val Thr Asn Val Val 
1               5                   10      


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR2 (ABM)

<400>  104

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR3 (ABM)

<400>  105

Gln Gln Tyr His Ser Tyr Pro Phe Thr 
1               5                   


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR1 (Kabat)

<400>  106

Asp Tyr Tyr Leu Asn 
1               5   


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR2 (Kabat)

<400>  107

Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VHCDR3 (Kabat)

<400>  108

Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR1 (Kabat)

<400>  109

Lys Ala Ser Gln Asn Val Val Thr Asn Val Val 
1               5                   10      


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR2 (Kabat)

<400>  110

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF2 VLCDR3 (Kabat)

<400>  111

Gln Gln Tyr His Ser Tyr Pro Phe Thr 
1               5                   


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR1 (Chothia)

<400>  112

Asp Ser Glu Val Phe Pro Ile Val 
1               5               


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR2 (Chothia)

<400>  113

Leu Pro Ser Phe Gly Arg 
1               5       


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR3 (Chothia)

<400>  114

Gly Asp His Gly Asn Trp Leu Ala Tyr 
1               5                   


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR1 (Chothia)

<400>  115

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR2 (Chothia)

<400>  116

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR3 (Chothia)

<400>  117

Gln Gln His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR1 (ABM)

<400>  118

Asp Ser Glu Val Phe Pro Ile Val Tyr Met Arg 
1               5                   10      


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR2 (ABM)

<400>  119

Asp Ile Leu Pro Ser Phe Gly Arg Thr 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR3 (ABM)

<400>  120

Gly Asp His Gly Asn Trp Leu Ala Tyr 
1               5                   


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR1 (ABM)

<400>  121

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR2 (ABM)

<400>  122

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR3 (ABM)

<400>  123

Gln Gln His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  124
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR1 (Kabat)

<400>  124

Pro Ile Val Tyr Met Arg 
1               5       


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR2 (Kabat)

<400>  125

Asp Ile Leu Pro Ser Phe Gly Arg Thr Ile Tyr Gly Glu Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VHCDR3 (Kabat)

<400>  126

Gly Asp His Gly Asn Trp Leu Ala Tyr 
1               5                   


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR1 (Kabat)

<400>  127

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR2 (Kabat)

<400>  128

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF4 VLCDR3 (Kabat)

<400>  129

Gln Gln His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR1 (Chothia)

<400>  130

Gly Phe Thr Phe Thr Asp Tyr 
1               5           


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR2 (Chothia)

<400>  131

Asn Thr Glu Thr Glu Glu 
1               5       


<210>  132
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR3 (Chothia)

<400>  132

Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
1               5                   10                  


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR1 (Chothia)

<400>  133

Arg Ser Ser Gln Ser Leu Ile His Thr Asn Gly Asp Thr Phe Leu His 
1               5                   10                  15      


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR2 (Chothia)

<400>  134

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR3 (Chothia)

<400>  135

Ser Gln Ser Ala Leu Phe Pro Tyr Thr 
1               5                   


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR1 (ABM)

<400>  136

Gly Phe Thr Phe Thr Asp Tyr Pro Met His 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR2 (ABM)

<400>  137

Trp Ile Asn Thr Glu Thr Glu Glu Pro Thr 
1               5                   10  


<210>  138
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR3 (ABM)

<400>  138

Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
1               5                   10                  


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR1 (ABM)

<400>  139

Arg Ser Ser Gln Ser Leu Ile His Thr Asn Gly Asp Thr Phe Leu His 
1               5                   10                  15      


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR2 (Kabat)

<400>  140

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR3 (ABM)

<400>  141

Ser Gln Ser Ala Leu Phe Pro Tyr Thr 
1               5                   


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR1 (Kabat)

<400>  142

Asp Tyr Pro Met His 
1               5   


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR2 (Kabat)

<400>  143

Trp Ile Asn Thr Glu Thr Glu Glu Pro Thr Tyr Ser Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VHCDR3 (Kabat)

<400>  144

Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
1               5                   10                  


<210>  145
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR1 (Kabat)

<400>  145

Arg Ser Ser Gln Ser Leu Ile His Thr Asn Gly Asp Thr Phe Leu His 
1               5                   10                  15      


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR2 (Kabat)

<400>  146

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VLCDR3 (Kabat)

<400>  147

Ser Gln Ser Ala Leu Phe Pro Tyr Thr 
1               5                   


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR1 (Chothia)

<400>  148

Gly Phe Thr Phe Ser Ala Tyr 
1               5           


<210>  149
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR2 (Chothia)

<400>  149

Asn Thr Gly Gly Ser Phe 
1               5       


<210>  150
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR3 (Chothia)

<400>  150

Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr 
1               5                   10          


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR1 (Chothia)

<400>  151

Ser Ala Ser Ser Asn Val Asn Tyr Met Ser 
1               5                   10  


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR2 (Chothia)

<400>  152

Leu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR3 (Chothia)

<400>  153

Gln Gln Trp Ser Ser Asp Pro Gln Thr 
1               5                   


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR1 (ABM)

<400>  154

Gly Phe Thr Phe Ser Ala Tyr Ser Met Ser 
1               5                   10  


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR2 (ABM)

<400>  155

Thr Ile Asn Thr Gly Gly Ser Phe Thr Tyr 
1               5                   10  


<210>  156
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR3 (ABM)

<400>  156

Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr 
1               5                   10          


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR2 (ABM)

<400>  157

Ser Ala Ser Ser Asn Val Asn Tyr Met Ser 
1               5                   10  


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR2 (ABM)

<400>  158

Leu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR3 (ABM)

<400>  159

Gln Gln Trp Ser Ser Asp Pro Gln Thr 
1               5                   


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR1 (Kabat)

<400>  160

Ser Ala Tyr Ser Met Ser 
1               5       


<210>  161
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR2 (Kabat)

<400>  161

Thr Ile Asn Thr Gly Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VHCDR3 (Kabat)

<400>  162

Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr 
1               5                   10          


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR1 (Kabat)

<400>  163

Ser Ala Ser Ser Asn Val Asn Tyr Met Ser 
1               5                   10  


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR2 (Kabat)

<400>  164

Leu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VLCDR3 (Kabat)

<400>  165

Gln Gln Trp Ser Ser Asp Pro Gln Thr 
1               5                   


<210>  166
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-46

<400>  166

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  167
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-2

<400>  167

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  168
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH1

<400>  168

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  169
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH2

<400>  169

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  170
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH3

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Gln Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ala Ser 
        115                 120         


<210>  171
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH4

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  172
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH5

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  173
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH6

<400>  173

Gln Val His Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Arg Pro Arg Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210>  174
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH7

<400>  174

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210>  175
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH8

<400>  175

Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210>  176
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-8

<400>  176

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Cys Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro 
                85                  90                  95  


<210>  177
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL1

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  178
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL2

<400>  178

Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  179
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL3

<400>  179

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  180
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL4

<400>  180

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Ser Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  181
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL5

<400>  181

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Cys Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  182
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL6

<400>  182

Asp Ile Gln Leu Thr Gln Ser Pro Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Glu Tyr Ser Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210>  183
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL7

<400>  183

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210>  184
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL8

<400>  184

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210>  185
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC0

<400>  185

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Lys Gln Arg Pro Arg Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  186
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC1

<400>  186

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  187
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC2

<400>  187

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  188
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC3

<400>  188

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Gln Gln Ala Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Gly 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ala Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  189
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC4

<400>  189

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  190
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC5

<400>  190

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  191
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC6

<400>  191

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val His Leu Gln Glu Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Arg Pro Arg Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  192
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC7

<400>  192

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  193
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HC8

<400>  193

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  194
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC0

<400>  194

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Pro Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Cys Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  195
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC1

<400>  195

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  196
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC2

<400>  196

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  197
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC3

<400>  197

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Val Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  198
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC4

<400>  198

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Leu Ala Thr Tyr Ser Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  199
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC5

<400>  199

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser 
            20                  25                  30          


Ala Ser Thr Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Cys Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  200
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC6

<400>  200

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Lys Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Glu Tyr Ser Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  201
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC7

<400>  201

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Pro Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Leu Ala Glu Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  202
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LC8

<400>  202

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Val Thr Asn Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Leu Ala Glu Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  203
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 Heavy Chain Signal Peptide

<400>  203

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  204
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 Light Chain Signal Peptide

<400>  204

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  

