                               SEQUENCE LISTING

<110> ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
 
<120> GENE KNOCK-OUTS TO IMPROVE T CELL FUNCTION

<130> 243734.000128

<140> PCT/US2020/029533
<141> 2020-04-23

<150> 62/912,231
<151> 2019-10-08

<150> 62/838,060
<151> 2019-04-24

<160> 42    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
aaggcagtgg tttcttacga                                                   20


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ggagtggaaa cgcttcatcg                                                   20


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
agagatcaaa cagctcaccg                                                   20


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
aggactcatc tgatgatgtg                                                   20


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
aagaagttac atcttaacac                                                   20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cactctatga ggatagtcat                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
tgatgcgccg gtaatcggag                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tggtgcgcga cagtcgccaa                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gtaccaatga gtgcaaagcg                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
atgacactta cggtactcgt                                                   20


<210> 11
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
tcgtcggcag cgtcagatgt gtataagaga cagttgtgga aaggacgaaa caccg            55


<210> 12
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gtctcgtggg ctcggagatg tgtataagag acagccactt tttcaagttg ataacgg          57


<210> 13
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
gacaaggaga tgcaggtatt gg                                                22


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
tcccgtagag atccacaaaa gt                                                22


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
acagcaaggc gaaaaaggat g                                                 21


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
tggtggacca ctcggatga                                                    19


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
tccgacagtg gttgatcgac                                                   20


<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
cctcacgatt gtagtcctgc tt                                                22


<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tgctgcccac tgtaacgtg                                                    19


<210> 20
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ggtaggtgaa ggatagccac at                                                22


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ccactctcga ccctacatgg                                                   20


<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
ggcccccaaa gtgacattta tt                                                22


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
cgccaccagt tcgccatgga                                                   20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tacagcccgg ggagcatcgt                                                   20


<210> 25
<211> 125
<212> PRT
<213> Homo sapiens

<400> 25
Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ala Asp Thr Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Thr Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Thr Ser Val Leu Asn Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ala Ser Thr Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Val Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210> 26
<211> 125
<212> PRT
<213> Mus musculus

<400> 26
Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Lys Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ala Asp Thr Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Thr Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Thr Ser Val Leu Ser Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ser Gly Thr Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Ile Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210> 27
<211> 913
<212> DNA
<213> Homo sapiens

<400> 27
aaagcgagcg acatgtccct ttggggagca gtccctctgc accccagagt gaggaggacg       60

caggggtcag aggtggctac agggcaggca gaggaggcac ctgtaggggg tggtgggctg      120

gtggcccagg agaagtcagg aagggagccc agctggtgac aagagagccc agaggtgcct      180

ggggctgagt gtgagagccc ggaagatttc agccatgcct cacagctccg acagcagtga      240

ctccagcttc agccgctctc ctccccctgg caaacaggac tcatctgatg atgtgagaag      300

agttcagagg agggagaaaa atcgtattgc cgcccagaag agccgacaga ggcagacaca      360

gaaggccgac accctgcacc tggagagcga agacctggag aaacagaacg cggctctacg      420

caaggagatc aagcagctca cagaggaact gaagtacttc acgtcggtgc tgaacagcca      480

cgagcccctg tgctcggtgc tggccgccag cacgccctcg ccccccgagg tggtgtacag      540

cgcccacgca ttccaccaac ctcatgtcag ctccccgcgc ttccagccct gagcttccga      600

tgcggggaga gcagagcctc gggaggggca cacagactgt ggcagagctg cgcccatccc      660

gcagaggccc ctgtccacct ggagacccgg agacagaggc ctggacaagg agtgaacacg      720

ggaactgtca cgactggaag ggcgtgaggc ctcccagcag tgccgcagcg tttcgagggg      780

cgtgtgctgg accccaccac tgtgggttgc aggcccaatg cagaagagta ttaagaaaga      840

tgctcaagtc ccatggcaca gagcaaggcg ggcagggaac ggttattttt ctaaataaat      900

gctttaaaag aaa                                                         913


<210> 28
<211> 904
<212> DNA
<213> Mus musculus

<400> 28
gcagtccctc tgcacccgag agagaggagg acgcaggggt ctgtcagagg ttgctgttgg       60

gcaagcaggg gaggtacctg tggaaggtgg tgtgctggtg gccccctagc agtcaagaag      120

gggagccagc tagtgagaag atcgcccaga ggcatctggg acggtgtggg agagcccgga      180

agattagaac catgcctcac agctccgaca gcagtgactc cagcttcagc cgctctcctc      240

cccctggcaa acaggactca tctgatgatg tgaggaaagt tcagaggaga gagaagaatc      300

gcatcgctgc ccagaagagc cgacagagac agacacagaa agccgacacc cttcacctgg      360

agagtgagga cctggagaaa cagaacgcag ctctccgcaa agagatcaaa cagctcaccg      420

aggagctcaa gtacttcaca tcagtgctga gcagccacga gcccctgtgc tccgtgctgg      480

ccagtggcac cccctcgccc cccgaggtgg tatacagtgc ccatgccttc caccagcctc      540

acatcagctc gccacgcttc cagccctgac cttctggaca agaagggcga tgctactccc      600

gtgatccctt ggaggggcat gtaaactgag gccgggctgc cctcatacct ctacccagag      660

gcccagtggc agaggcctgg acaagtattg aacacaagaa ctgtagtggt cagagggact      720

taaggcctcc cagggaagta tagtcaatgt actggactct cccagggaag tcgagccaat      780

gtactggacc caaaaaatga caagtcaacc ctggactgtc atgaatgatg cccaaaatac      840

acagcacaga gggaggaggg cagggggtgg atagttttct aaataaatat tttctaaaaa      900

acca                                                                   904


<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, or g

<400> 29
ttcacaccat cacgacgcgt ngg                                               23


<210> 30
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, or g

<400> 30
tgggggcagc ttggccgctc ngg                                               23


<210> 31
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, or g

<400> 31
tatgccccct gatgacccac ngg                                               23


<210> 32
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, or g

<400> 32
aaggaggtct tctcctgccg ngg                                               23


<210> 33
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, or g

<400> 33
gtgatgggca cgtcgggccg ngg                                               23


<210> 34
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, or g

<400> 34
cagctccctc tagtcccgcg ngg                                               23


<210> 35
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, u, or g

<400> 35
gcuuguggau guugcggaag ngg                                               23


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
ttcacaccat cacgacgcgt                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
tgggggcagc ttggccgctc                                                   20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
tatgccccct gatgacccac                                                   20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
aaggaggtct tctcctgccg                                                   20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
gtgatgggca cgtcgggccg                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
cagctccctc tagtcccgcg                                                   20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
ggtagagggt tactacccgg                                                   20


