                         SEQUENCE LISTING

<110>  University of California - Berkeley
       Schaffer, David V.
       Barnes, Christopher
       Ojala, David S
 
<120>  Cells for Enhanced Production of Adeno-Associated Virus

<130>  BERK-408WO

<150>  US 62/839,375
<151>  2019-04-26

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Glu Val Gly His Asn Leu Glu Ser Pro Glu Thr Pro Gly 
1               5                   10                  15      


Gly Gly Gly Trp Thr Arg Val Glu Phe Pro Pro Pro Ala Pro Lys Gly 
            20                  25                  30          


Ala Ala Thr Val Trp Cys Leu Asn Arg Leu Gly Ser Arg Lys Leu Ser 
        35                  40                  45              


Leu Ile Trp Ile Thr Phe Asn Thr Gly Trp Asn Met Lys Ser Arg Leu 
    50                  55                  60                  


Ile Ile Leu Ile Gln Gln Val Ser Cys His His 
65                  70                  75  


<210>  2
<211>  58
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2
gaguuauggg gucaucuauc cuucccuugg aaaaugaucu gagaugacac uguagcuc         58


<210>  3
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Met Gly Leu Phe Arg Val Cys Leu Val Val Val Thr Ala Ile 
1               5                   10                  15      


Ile Asn His Pro Leu Leu Phe Pro Arg Glu Asn Ala Thr Val Pro Glu 
            20                  25                  30          


Asn Glu Glu Glu Ile Ile Arg Lys Met Gln Ala His Gln Glu Lys Leu 
        35                  40                  45              


Gln Leu Glu Gln Leu Arg Leu Glu Glu Glu Val Ala Arg Leu Ala Ala 
    50                  55                  60                  


Glu Lys Glu Ala Leu Glu Gln Val Ala Glu Glu Gly Arg Gln Gln Asn 
65                  70                  75                  80  


Glu Thr Arg Val Thr Trp Asp Leu Trp Ser Thr Leu Cys Met Ile Leu 
                85                  90                  95      


Phe Leu Met Ile Glu Val Trp Arg Gln Asp His Gln Glu Gly Pro Ser 
            100                 105                 110         


Pro Glu Cys Leu Gly Gly Glu Glu Asp Glu Leu Pro Gly Leu Gly Gly 
        115                 120                 125             


Ala Pro Leu Gln Gly Leu Thr Leu Pro Asn Lys Ala Thr Leu Gly His 
    130                 135                 140                 


Phe Tyr Glu Arg Cys Ile Arg Gly Ala Thr Ala Asp Ala Ala Arg Thr 
145                 150                 155                 160 


Arg Glu Phe Leu Glu Gly Phe Val Asp Asp Leu Leu Glu Ala Leu Arg 
                165                 170                 175     


Ser Leu Cys Asn Arg Asp Thr Asp Met Glu Val Glu Asp Phe Ile Gly 
            180                 185                 190         


Val Asp Ser Met Tyr Glu Asn Trp Gln Val Asp Arg Pro Leu Leu Cys 
        195                 200                 205             


His Leu Phe Val Pro Phe Thr Pro Pro Glu Pro Tyr Arg Phe His Pro 
    210                 215                 220                 


Glu Leu Trp Cys Ser Gly Arg Ser Val Pro Leu Asp Arg Gln Gly Tyr 
225                 230                 235                 240 


Gly Gln Ile Lys Val Val Arg Ala Asp Gly Asp Thr Leu Ser Cys Ile 
                245                 250                 255     


Cys Gly Lys Thr Lys Leu Gly Glu Asp Met Leu Cys Leu Leu His Gly 
            260                 265                 270         


Arg Asn Ser Met Ala Pro Pro Cys Gly Asp Met Glu Asn Leu Leu Cys 
        275                 280                 285             


Ala Thr Asp Ser Leu Tyr Leu Asp Thr Met Gln Val Met Lys Trp Phe 
    290                 295                 300                 


Gln Thr Ala Leu Thr Arg Ala Trp Lys Gly Ile Ala His Lys Tyr Glu 
305                 310                 315                 320 


Phe Asp Leu Ala Phe Gly Gln Leu Asp Ser Pro Gly Ser Leu Lys Ile 
                325                 330                 335     


Lys Phe Arg Ser Gly Lys Phe Met Pro Phe Asn Leu Ile Pro Val Ile 
            340                 345                 350         


Gln Cys Asp Asp Ser Asp Leu Tyr Phe Val Ser His Leu Pro Arg Glu 
        355                 360                 365             


Pro Ser Glu Gly Thr Pro Ala Ser Ser Thr Asp Trp Leu Leu Ser Phe 
    370                 375                 380                 


Ala Val Tyr Glu Arg His Phe Leu Arg Thr Thr Leu Lys Ala Leu Pro 
385                 390                 395                 400 


Glu Gly Ala Cys His Leu Ser Cys Leu Gln Ile Ala Ser Phe Leu Leu 
                405                 410                 415     


Ser Lys Gln Ser Arg Leu Thr Gly Pro Ser Gly Leu Ser Ser Tyr His 
            420                 425                 430         


Leu Lys Thr Ala Leu Leu His Leu Leu Leu Leu Arg Gln Ala Ala Asp 
        435                 440                 445             


Trp Lys Ala Gly Gln Leu Asp Ala Arg Leu His Glu Leu Leu Cys Phe 
    450                 455                 460                 


Leu Glu Lys Ser Leu Leu Gln Lys Lys Leu His His Phe Phe Ile Gly 
465                 470                 475                 480 


Asn Arg Lys Val Pro Glu Ala Met Gly Leu Pro Glu Ala Val Leu Arg 
                485                 490                 495     


Ala Glu Pro Leu Asn Leu Phe Arg Pro Phe Val Leu Gln Arg Ser Leu 
            500                 505                 510         


Tyr Arg Lys Thr Leu Asp Ser Phe Tyr Glu Met Leu Lys Asn Ala Pro 
        515                 520                 525             


Ala Leu Ile Ser Glu Tyr Ser Leu His Val Pro Ser Asp Gln Pro Thr 
    530                 535                 540                 


Pro Lys Ser 
545         


<210>  4
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Cys Pro Lys Ser Ala Val Thr Met Arg Asn Glu Glu Leu Leu 
1               5                   10                  15      


Leu Ser Asn Gly Thr Ala Asn Lys Met Asn Gly Ala Leu Asp His Ser 
            20                  25                  30          


Asp Gln Pro Asp Pro Asp Ala Ile Lys Met Phe Val Gly Gln Ile Pro 
        35                  40                  45              


Arg Ser Trp Ser Glu Lys Glu Leu Lys Glu Leu Phe Glu Pro Tyr Gly 
    50                  55                  60                  


Ala Val Tyr Gln Ile Asn Val Leu Arg Asp Arg Ser Gln Asn Pro Pro 
65                  70                  75                  80  


Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg Lys Ala Ala 
                85                  90                  95      


Leu Glu Ala Gln Asn Ala Leu His Asn Ile Lys Thr Leu Pro Gly Met 
            100                 105                 110         


His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys Ser Asn Ala 
        115                 120                 125             


Val Glu Asp Arg Lys Leu Phe Ile Gly Met Val Ser Lys Lys Cys Asn 
    130                 135                 140                 


Glu Asn Asp Ile Arg Val Met Phe Ser Pro Phe Gly Gln Ile Glu Glu 
145                 150                 155                 160 


Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly Cys Ala Phe 
                165                 170                 175     


Val Thr Phe Ser Thr Arg Ala Met Ala Gln Asn Ala Ile Lys Ala Met 
            180                 185                 190         


His Gln Ser Gln Thr Met Glu Gly Cys Ser Ser Pro Ile Val Val Lys 
        195                 200                 205             


Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Arg Arg Leu Gln Gln Gln 
    210                 215                 220                 


Leu Ala Gln Gln Met Gln Gln Leu Asn Thr Ala Thr Trp Gly Asn Leu 
225                 230                 235                 240 


Thr Gly Leu Gly Gly Leu Thr Pro Gln Tyr Leu Ala Leu Leu Gln Gln 
                245                 250                 255     


Ala Thr Ser Ser Ser Asn Leu Gly Ala Phe Ser Gly Ile Gln Gln Met 
            260                 265                 270         


Ala Gly Met Asn Ala Leu Gln Leu Gln Asn Leu Ala Thr Leu Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Gln Thr Ser Ala Thr Ser Thr Asn Ala Asn Pro 
    290                 295                 300                 


Leu Ser Thr Thr Ser Ser Ala Leu Gly Ala Leu Thr Ser Pro Val Ala 
305                 310                 315                 320 


Ala Ser Thr Pro Asn Ser Thr Ala Gly Ala Ala Met Asn Ser Leu Thr 
                325                 330                 335     


Ser Leu Gly Thr Leu Gln Gly Leu Ala Gly Ala Thr Val Gly Leu Asn 
            340                 345                 350         


Asn Ile Asn Ala Leu Ala Gly Met Ala Ala Leu Asn Gly Gly Leu Gly 
        355                 360                 365             


Ala Thr Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr 
    370                 375                 380                 


Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr 
385                 390                 395                 400 


Leu Tyr Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln 
                405                 410                 415     


Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln 
            420                 425                 430         


Glu Phe Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn 
        435                 440                 445             


Val Ile Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys 
    450                 455                 460                 


Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala 
465                 470                 475                 480 


Ile Gln Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val 
                485                 490                 495     


Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
            500                 505             


<210>  5
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Ser Ser Ser Glu Ser Asp His Phe Arg Cys Arg Asp Arg 
1               5                   10                  15      


Leu Ser Pro Trp Ala Ala Arg Ser Thr His Arg Gly Thr Arg Ser Leu 
            20                  25                  30          


Pro Thr Val Glu Val Thr Glu Lys Val Asn Thr Ile Thr Ser Thr Leu 
        35                  40                  45              


Gln Asp Thr Ser Arg Asn Leu Arg Gln Val Asp Gln Met Leu Gly Arg 
    50                  55                  60                  


Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile Glu His Leu Lys 
65                  70                  75                  80  


Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser Gln Arg Leu Leu 
                85                  90                  95      


Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser Leu Ser Ala Ser 
            100                 105                 110         


Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His Phe Pro Pro Thr 
        115                 120                 125             


Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile Lys Arg Met Arg 
    130                 135                 140                 


Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp Asp Met Thr Gln 
145                 150                 155                 160 


Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser Ser Glu Gln Ile 
                165                 170                 175     


Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg Arg Ser Arg Ser 
            180                 185                 190         


Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr Glu Lys Leu Asn 
        195                 200                 205             


Glu Ala Gln Lys Gln Glu Val Val Ser Asp Arg Val Glu Arg Arg Leu 
    210                 215                 220                 


Gln Glu Leu Glu Arg Glu Met Arg Thr Glu Arg Glu Leu Val Glu Arg 
225                 230                 235                 240 


Arg Gln Asp Gln Leu Gly Leu Met Ser Leu Gln Leu Gln Glu Ala Leu 
                245                 250                 255     


Lys Lys Gln Glu Ala Lys Ala Asp Glu His Glu Gly Ala Ile Lys Asn 
            260                 265                 270         


Lys Leu Arg Gln Thr Glu Thr Glu Lys Asn Gln Leu Glu Gln Glu Leu 
        275                 280                 285             


Glu Leu Ser Arg Arg Leu Leu Asn Gln Ser Glu Gly Ser Arg Glu Thr 
    290                 295                 300                 


Leu Leu His Gln Val Glu Glu Leu Arg Thr Gln Leu Thr Lys Ala Glu 
305                 310                 315                 320 


Gly Asp Arg Lys Gly Leu Gln His Gln Val Ser Gln Ile Ser Lys Gln 
                325                 330                 335     


Gln Ser Asn Tyr Gln Asp Glu Gln Gly Glu Asp Trp Arg Phe Arg Arg 
            340                 345                 350         


Gly Val Glu Arg Glu Lys Gln Asp Leu Glu Lys Gln Met Ser Asp Leu 
        355                 360                 365             


Arg Val Gln Leu Asn Phe Ser Ala Met Ala Ser Glu Leu Glu Glu Val 
    370                 375                 380                 


Lys Arg Cys Met Glu Arg Lys Asp Lys Glu Lys Ala His Leu Ala Ser 
385                 390                 395                 400 


Gln Val Glu Asn Leu Thr Arg Glu Leu Glu Asn Gly Glu Lys Gln Gln 
                405                 410                 415     


Leu Gln Met Leu Asp Arg Leu Lys Glu Ile Gln Asn His Phe Asp Thr 
            420                 425                 430         


Cys Glu Ala Glu Arg Lys His Ala Asp Leu Gln Ile Ser Glu Leu Thr 
        435                 440                 445             


Arg His Ala Glu Asp Ala Thr Lys Gln Ala Glu Arg Tyr Leu Ser Glu 
    450                 455                 460                 


Leu Gln Gln Ser Glu Ala Leu Lys Glu Glu Ala Glu Lys Arg Arg Glu 
465                 470                 475                 480 


Asp Leu Lys Leu Lys Ala Gln Glu Ser Ile Arg Gln Trp Lys Leu Lys 
                485                 490                 495     


His Lys Lys Leu Glu Arg Ala Leu Glu Lys Gln Ser Glu Thr Val Asp 
            500                 505                 510         


Glu Leu Thr Gly Lys Asn Asn Gln Ile Leu Lys Glu Lys Asp Glu Leu 
        515                 520                 525             


Lys Thr Gln Leu Tyr Ala Ala Leu Gln Gln Ile Glu Asn Leu Arg Lys 
    530                 535                 540                 


Glu Leu Asn Asp Val Leu Thr Lys Arg Ala Leu Gln Glu Glu Glu Leu 
545                 550                 555                 560 


His Ser Lys Glu Glu Lys Leu Arg Asp Ile Lys Ser His Gln Ala Asp 
                565                 570                 575     


Leu Glu Leu Glu Val Lys Asn Ser Leu Asp Thr Ile His Arg Leu Glu 
            580                 585                 590         


Ser Glu Leu Lys Lys Gln Ser Lys Ile Gln Ser Gln Met Lys Val Glu 
        595                 600                 605             


Lys Ala His Leu Glu Glu Glu Ile Ala Glu Leu Lys Lys Ser Gln Ala 
    610                 615                 620                 


Gln Asp Lys Ala Lys Leu Leu Glu Met Gln Glu Ser Ile Lys Asp Leu 
625                 630                 635                 640 


Ser Ala Ile Arg Ala Asp Leu Ala Asn Lys Leu Ala Glu Glu Glu Arg 
                645                 650                 655     


Ala Lys Lys Ala Val Leu Lys Asp Leu Ser Asp Leu Thr Ala Gln Ala 
            660                 665                 670         


Lys Ser Arg Asp Glu Glu Thr Ala Thr Ile Ile Thr Gln Leu Lys Leu 
        675                 680                 685             


Glu Arg Asp Val His Gln Arg Glu Leu Lys Asp Leu Thr Ser Ser Leu 
    690                 695                 700                 


Gln Ser Val Lys Thr Lys His Glu Gln Asn Ile Gln Glu Leu Met Lys 
705                 710                 715                 720 


His Phe Lys Lys Glu Lys Ser Glu Ala Glu Asn His Ile Arg Thr Leu 
                725                 730                 735     


Lys Ala Glu Ser Leu Glu Glu Lys Asn Met Ala Lys Ile His Arg Gly 
            740                 745                 750         


Gln Leu Glu Lys Leu Lys Ser Gln Cys Asp Arg Leu Thr Glu Glu Leu 
        755                 760                 765             


Thr Gln Asn Glu Asn Glu Asn Lys Lys Leu Lys Leu Lys Tyr Gln Cys 
    770                 775                 780                 


Leu Lys Asp Gln Leu Glu Glu Arg Glu Lys His Ile Ser Ile Glu Glu 
785                 790                 795                 800 


Glu His Leu Arg Arg Met Glu Glu Ala Arg Leu Gln Leu Lys Asp Gln 
                805                 810                 815     


Leu Leu Cys Leu Glu Thr Glu Gln Glu Ser Ile Leu Gly Val Ile Gly 
            820                 825                 830         


Lys Glu Ile Asp Ala Ala Cys Lys Thr Phe Ser Lys Asp Ser Val Glu 
        835                 840                 845             


Lys Leu Lys Val Phe Ser Ser Gly Pro Asp Ile His Tyr Asp Pro His 
    850                 855                 860                 


Arg Trp Leu Ala Glu Ser Lys Thr Lys Leu Gln Trp Leu Cys Glu Glu 
865                 870                 875                 880 


Leu Lys Glu Arg Glu Asn Arg Glu Lys Asn Leu Arg His Gln Leu Met 
                885                 890                 895     


Leu Cys Arg Gln Gln Leu Arg Asn Leu Thr Glu Asn Lys Glu Ser Glu 
            900                 905                 910         


Leu Gln Cys Leu Phe Gln Gln Ile Glu Arg Gln Glu Gln Leu Leu Asp 
        915                 920                 925             


Glu Ile His Arg Glu Lys Arg Asp Leu Leu Glu Glu Thr Gln Arg Lys 
    930                 935                 940                 


Asp Glu Glu Met Gly Ser Leu Gln Asp Arg Val Ile Ala Leu Glu Thr 
945                 950                 955                 960 


Ser Thr Gln Val Ala Leu Asp His Leu Glu Ser Val Pro Glu Lys Leu 
                965                 970                 975     


Ser Leu Leu Glu Asp Phe Lys Asp Phe Arg Asp Ser Cys Ser Ser Ser 
            980                 985                 990         


Glu Arg Thr Asp Gly Arg Tyr Ser  Lys Tyr Arg Val Arg  Arg Asn Ser 
        995                 1000                 1005             


Leu Gln  His His Gln Asp Asp  Thr Lys Tyr Arg Thr  Lys Ser Phe 
    1010                 1015                 1020             


Lys Gly  Asp Arg Thr Phe Leu  Glu Gly Ser His Thr  Arg Gly Leu 
    1025                 1030                 1035             


Asp His  Ser Ser Ser Trp Gln  Asp His Ser Arg Phe  Leu Ser Ser 
    1040                 1045                 1050             


Pro Arg  Phe Ser Tyr Val Asn  Ser Phe Thr Lys Arg  Thr Val Ala 
    1055                 1060                 1065             


Pro Asp  Ser Ala Ser Asn Lys  Glu Asp Ala Thr Met  Asn Gly Thr 
    1070                 1075                 1080             


Ser Ser  Gln Pro Lys Lys Glu  Glu Tyr Gly Ser 
    1085                 1090                 


<210>  6
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Ser Ile Arg Arg Gly Arg Gly Ala Trp Thr Arg Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Glu Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Val Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Met Thr Val Lys Thr Ile Arg Phe Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ala Leu Leu Ser Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Phe Phe Phe Leu Asp Ile Gln Ala Asn Asp Glu Leu Ser Glu Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Gly Lys Ser Leu Asp Arg Glu Glu Thr Ala Glu Val 
        195                 200                 205             


Asn Leu Leu Leu Val Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Lys Val Leu Asp Val Asn Asp Asn Glu Pro 
225                 230                 235                 240 


Thr Phe Ala Gln Ser Val Tyr Lys Val Lys Leu Leu Glu Asn Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Pro Asn Ser Glu Ile Val Tyr Ser Leu Gly Ser Asp Val Ser Ser Thr 
        275                 280                 285             


Ile Gln Thr Lys Phe Thr Ile Asp Pro Ile Ser Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Tyr Glu Glu Ala Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Thr Ala Thr Asp Lys Gly Thr Pro Ser Met Ser Gly His Cys Lys Ile 
                325                 330                 335     


Ser Leu Lys Leu Val Asp Ile Asn Asp Asn Thr Pro Glu Val Ser Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Ser Glu Asn Ala Ser Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Thr Asn Gly His 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Thr Ser Val Ser Ile Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Thr Ala Ala Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Gly Thr Gly Ser Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Trp Val Gly Ala Ala Gly 
        675                 680                 685             


Ser Glu Ala Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Val Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Arg Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Asp Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Gln Gly Pro Asp Ser Ala Glu 
    770                 775                 780                 


Glu Lys Gln Leu Ser Glu Ser Glu Tyr Val Gly Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  7
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                565                 570                 575     


Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
            580                 585                 590         


Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
        595                 600                 605             


Asp Arg Cys Ser Asp Leu 
    610                 


<210>  8
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Glu Gly Gly Gly Gly Val Arg Ser Leu Val Pro Gly Gly Pro 
1               5                   10                  15      


Val Leu Leu Val Leu Cys Gly Leu Leu Glu Ala Ser Gly Gly Gly Arg 
            20                  25                  30          


Ala Leu Pro Gln Leu Ser Asp Asp Ile Pro Phe Arg Val Asn Trp Pro 
        35                  40                  45              


Gly Thr Glu Phe Ser Leu Pro Thr Thr Gly Val Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Asn Tyr Val Ile Met Thr Thr Ala His Lys Glu Lys Tyr Lys Cys Ile 
65                  70                  75                  80  


Leu Pro Leu Val Thr Ser Gly Asp Glu Glu Glu Glu Lys Asp Tyr Lys 
                85                  90                  95      


Gly Pro Asn Pro Arg Glu Leu Leu Glu Pro Leu Phe Lys Gln Ser Ser 
            100                 105                 110         


Cys Ser Tyr Arg Ile Glu Ser Tyr Trp Thr Tyr Glu Val Cys His Gly 
        115                 120                 125             


Lys His Ile Arg Gln Tyr His Glu Glu Lys Glu Thr Gly Gln Lys Ile 
    130                 135                 140                 


Asn Ile His Glu Tyr Tyr Leu Gly Asn Met Leu Ala Lys Asn Leu Leu 
145                 150                 155                 160 


Phe Glu Lys Glu Arg Glu Ala Glu Glu Lys Glu Lys Ser Asn Glu Ile 
                165                 170                 175     


Pro Thr Lys Asn Ile Glu Gly Gln Met Thr Pro Tyr Tyr Pro Val Gly 
            180                 185                 190         


Met Gly Asn Gly Thr Pro Cys Ser Leu Lys Gln Asn Arg Pro Arg Ser 
        195                 200                 205             


Ser Thr Val Met Tyr Ile Cys His Pro Glu Ser Lys His Glu Ile Leu 
    210                 215                 220                 


Ser Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val Val Ile Leu Thr 
225                 230                 235                 240 


Pro Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg Ala Ser Pro Val 
                245                 250                 255     


Asn Asp Ile Phe Cys Gln Ser Leu Pro Gly Ser Pro Phe Lys Pro Leu 
            260                 265                 270         


Thr Leu Arg Gln Leu Glu Gln Gln Glu Glu Ile Leu Arg Val Pro Phe 
        275                 280                 285             


Arg Arg Asn Lys Glu Glu Asp Leu Gln Ser Thr Lys Glu Glu Arg Phe 
    290                 295                 300                 


Pro Ala Ile His Lys Ser Ile Ala Ile Gly Ser Gln Pro Val Leu Thr 
305                 310                 315                 320 


Val Gly Thr Thr His Ile Ser Lys Leu Thr Asp Asp Gln Leu Ile Lys 
                325                 330                 335     


Glu Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp 
            340                 345                 350         


Lys Tyr Glu Phe Cys Tyr Gly Lys His Val His Gln Tyr His Glu Asp 
        355                 360                 365             


Lys Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr Trp Asn Gln Glu 
    370                 375                 380                 


Glu His Ile Glu Trp Ala Lys Lys Asn Thr Ala Arg Ala Tyr His Leu 
385                 390                 395                 400 


Gln Asp Asp Gly Thr Gln Thr Val Arg Met Val Ser His Phe Tyr Gly 
                405                 410                 415     


Asn Gly Asp Ile Cys Asp Ile Thr Asp Lys Pro Arg Gln Val Thr Val 
            420                 425                 430         


Lys Leu Lys Cys Lys Glu Ser Asp Ser Pro His Ala Val Thr Val Tyr 
        435                 440                 445             


Met Leu Glu Pro His Ser Cys Gln Tyr Ile Leu Gly Val Glu Ser Pro 
    450                 455                 460                 


Val Ile Cys Lys Ile Leu Asp Thr Ala Asp Glu Asn Gly Leu Leu Ser 
465                 470                 475                 480 


Leu Pro Asn 
            


<210>  9
<211>  960
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Ser Ala Arg Ala Lys Thr Pro Arg Lys Pro Thr Val Lys Lys 
1               5                   10                  15      


Gly Ser Gln Thr Asn Leu Lys Asp Pro Val Gly Val Tyr Cys Arg Val 
            20                  25                  30          


Arg Pro Leu Gly Phe Pro Asp Gln Glu Cys Cys Ile Glu Val Ile Asn 
        35                  40                  45              


Asn Thr Thr Val Gln Leu His Thr Pro Glu Gly Tyr Arg Leu Asn Arg 
    50                  55                  60                  


Asn Gly Asp Tyr Lys Glu Thr Gln Tyr Ser Phe Lys Gln Val Phe Gly 
65                  70                  75                  80  


Thr His Thr Thr Gln Lys Glu Leu Phe Asp Val Val Ala Asn Pro Leu 
                85                  90                  95      


Val Asn Asp Leu Ile His Gly Lys Asn Gly Leu Leu Phe Thr Tyr Gly 
            100                 105                 110         


Val Thr Gly Ser Gly Lys Thr His Thr Met Thr Gly Ser Pro Gly Glu 
        115                 120                 125             


Gly Gly Leu Leu Pro Arg Cys Leu Asp Met Ile Phe Asn Ser Ile Gly 
    130                 135                 140                 


Ser Phe Gln Ala Lys Arg Tyr Val Phe Lys Ser Asn Asp Arg Asn Ser 
145                 150                 155                 160 


Met Asp Ile Gln Cys Glu Val Asp Ala Leu Leu Glu Arg Gln Lys Arg 
                165                 170                 175     


Glu Ala Met Pro Asn Pro Lys Thr Ser Ser Ser Lys Arg Gln Val Asp 
            180                 185                 190         


Pro Glu Phe Ala Asp Met Ile Thr Val Gln Glu Phe Cys Lys Ala Glu 
        195                 200                 205             


Glu Val Asp Glu Asp Ser Val Tyr Gly Val Phe Val Ser Tyr Ile Glu 
    210                 215                 220                 


Ile Tyr Asn Asn Tyr Ile Tyr Asp Leu Leu Glu Glu Val Pro Phe Asp 
225                 230                 235                 240 


Pro Ile Lys Pro Lys Pro Pro Gln Ser Lys Leu Leu Arg Glu Asp Lys 
                245                 250                 255     


Asn His Asn Met Tyr Val Ala Gly Cys Thr Glu Val Glu Val Lys Ser 
            260                 265                 270         


Thr Glu Glu Ala Phe Glu Val Phe Trp Arg Gly Gln Lys Lys Arg Arg 
        275                 280                 285             


Ile Ala Asn Thr His Leu Asn Arg Glu Ser Ser Arg Ser His Ser Val 
    290                 295                 300                 


Phe Asn Ile Lys Leu Val Gln Ala Pro Leu Asp Ala Asp Gly Asp Asn 
305                 310                 315                 320 


Val Leu Gln Glu Lys Glu Gln Ile Thr Ile Ser Gln Leu Ser Leu Val 
                325                 330                 335     


Asp Leu Ala Gly Ser Glu Arg Thr Asn Arg Thr Arg Ala Glu Gly Asn 
            340                 345                 350         


Arg Leu Arg Glu Ala Gly Asn Ile Asn Gln Ser Leu Met Thr Leu Arg 
        355                 360                 365             


Thr Cys Met Asp Val Leu Arg Glu Asn Gln Met Tyr Gly Thr Asn Lys 
    370                 375                 380                 


Met Val Pro Tyr Arg Asp Ser Lys Leu Thr His Leu Phe Lys Asn Tyr 
385                 390                 395                 400 


Phe Asp Gly Glu Gly Lys Val Arg Met Ile Val Cys Val Asn Pro Lys 
                405                 410                 415     


Ala Glu Asp Tyr Glu Glu Asn Leu Gln Val Met Arg Phe Ala Glu Val 
            420                 425                 430         


Thr Gln Glu Val Glu Val Ala Arg Pro Val Asp Lys Ala Ile Cys Gly 
        435                 440                 445             


Leu Thr Pro Gly Arg Arg Tyr Arg Asn Gln Pro Arg Gly Pro Val Gly 
    450                 455                 460                 


Asn Glu Pro Leu Val Thr Asp Val Val Leu Gln Ser Phe Pro Pro Leu 
465                 470                 475                 480 


Pro Ser Cys Glu Ile Leu Asp Ile Asn Asp Glu Gln Thr Leu Pro Arg 
                485                 490                 495     


Leu Ile Glu Ala Leu Glu Lys Arg His Asn Leu Arg Gln Met Met Ile 
            500                 505                 510         


Asp Glu Phe Asn Lys Gln Ser Asn Ala Phe Lys Ala Leu Leu Gln Glu 
        515                 520                 525             


Phe Asp Asn Ala Val Leu Ser Lys Glu Asn His Met Gln Gly Lys Leu 
    530                 535                 540                 


Asn Glu Lys Glu Lys Met Ile Ser Gly Gln Lys Leu Glu Ile Glu Arg 
545                 550                 555                 560 


Leu Glu Lys Lys Asn Lys Thr Leu Glu Tyr Lys Ile Glu Ile Leu Glu 
                565                 570                 575     


Lys Thr Thr Thr Ile Tyr Glu Glu Asp Lys Arg Asn Leu Gln Gln Glu 
            580                 585                 590         


Leu Glu Thr Gln Asn Gln Lys Leu Gln Arg Gln Phe Ser Asp Lys Arg 
        595                 600                 605             


Arg Leu Glu Ala Arg Leu Gln Gly Met Val Thr Glu Thr Thr Met Lys 
    610                 615                 620                 


Trp Glu Lys Glu Cys Glu Arg Arg Val Ala Ala Lys Gln Leu Glu Met 
625                 630                 635                 640 


Gln Asn Lys Leu Trp Val Lys Asp Glu Lys Leu Lys Gln Leu Lys Ala 
                645                 650                 655     


Ile Val Thr Glu Pro Lys Thr Glu Lys Pro Glu Arg Pro Ser Arg Glu 
            660                 665                 670         


Arg Asp Arg Glu Lys Val Thr Gln Arg Ser Val Ser Pro Ser Pro Val 
        675                 680                 685             


Pro Leu Ser Ser Asn Tyr Ile Ala Gln Ile Ser Asn Gly Gln Gln Leu 
    690                 695                 700                 


Met Ser Gln Pro Gln Leu His Arg Arg Ser Asn Ser Cys Ser Ser Ile 
705                 710                 715                 720 


Ser Val Ala Ser Cys Ile Ser Glu Trp Glu Gln Lys Ile Pro Thr Tyr 
                725                 730                 735     


Asn Thr Pro Leu Lys Val Thr Ser Ile Ala Arg Arg Arg Gln Gln Glu 
            740                 745                 750         


Pro Gly Gln Ser Lys Thr Cys Ile Val Ser Asp Arg Arg Arg Gly Met 
        755                 760                 765             


Tyr Trp Thr Glu Gly Arg Glu Val Val Pro Thr Phe Arg Asn Glu Ile 
    770                 775                 780                 


Glu Ile Glu Glu Asp His Cys Gly Arg Leu Leu Phe Gln Pro Asp Gln 
785                 790                 795                 800 


Asn Ala Pro Pro Ile Arg Leu Arg His Arg Arg Ser Arg Ser Ala Gly 
                805                 810                 815     


Asp Arg Trp Val Asp His Lys Pro Ala Ser Asn Met Gln Thr Glu Thr 
            820                 825                 830         


Val Met Gln Pro His Val Pro His Ala Ile Thr Val Ser Val Ala Asn 
        835                 840                 845             


Glu Lys Ala Leu Ala Lys Cys Glu Lys Tyr Met Leu Thr His Gln Glu 
    850                 855                 860                 


Leu Ala Ser Asp Gly Glu Ile Glu Thr Lys Leu Ile Lys Gly Asp Ile 
865                 870                 875                 880 


Tyr Lys Thr Arg Gly Gly Gly Gln Ser Val Gln Phe Thr Asp Ile Glu 
                885                 890                 895     


Thr Leu Lys Gln Glu Ser Pro Asn Gly Ser Arg Lys Arg Arg Ser Ser 
            900                 905                 910         


Thr Val Ala Pro Ala Gln Pro Asp Gly Ala Glu Ser Glu Trp Thr Asp 
        915                 920                 925             


Val Glu Thr Arg Cys Ser Val Ala Val Glu Met Arg Ala Gly Ser Gln 
    930                 935                 940                 


Leu Gly Pro Gly Tyr Gln His His Ala Gln Pro Lys Arg Lys Lys Pro 
945                 950                 955                 960 


<210>  10
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Glu Ile Arg Lys Asp Thr Leu Lys Ala Ile Leu Leu Glu Leu 
1               5                   10                  15      


Glu Cys His Phe Thr Trp Asn Leu Leu Lys Glu Asp Ile Asp Leu Phe 
            20                  25                  30          


Glu Val Glu Asp Thr Ile Gly Gln Gln Leu Glu Phe Leu Thr Thr Lys 
        35                  40                  45              


Ser Arg Leu Ala Leu Tyr Asn Leu Leu Ala Tyr Val Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Lys Asp Ala Leu Glu Cys Leu Glu Gln Ala Glu Glu Ile 
65                  70                  75                  80  


Ile Gln Gln Glu His Ser Asp Lys Glu Glu Val Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Asp Gln Leu Glu Glu 
            100                 105                 110         


Ala Gln Lys Tyr Thr Gly Lys Ile Gly Asn Val Cys Lys Lys Leu Ser 
        115                 120                 125             


Ser Pro Ser Asn Tyr Lys Leu Glu Cys Pro Glu Thr Asp Cys Glu Lys 
    130                 135                 140                 


Gly Trp Ala Leu Leu Lys Phe Gly Gly Lys Tyr Tyr Gln Lys Ala Lys 
145                 150                 155                 160 


Ala Ala Phe Glu Lys Ala Leu Glu Val Glu Pro Asp Asn Pro Glu Phe 
                165                 170                 175     


Asn Ile Gly Tyr Ala Ile Thr Val Tyr Arg Leu Asp Asp Ser Asp Arg 
            180                 185                 190         


Glu Gly Ser Val Lys Ser Phe Ser Leu Gly Pro Leu Arg Lys Ala Val 
        195                 200                 205             


Thr Leu Asn Pro Asp Asn Ser Tyr Ile Lys Val Phe Leu Ala Leu Lys 
    210                 215                 220                 


Leu Gln Asp Val His Ala Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu 
225                 230                 235                 240 


Ile Leu Asp Gln Ile Ser Ser Gln Pro Tyr Val Leu Arg Tyr Ala Ala 
                245                 250                 255     


Lys Phe Tyr Arg Arg Lys Asn Ser Trp Asn Lys Ala Leu Glu Leu Leu 
            260                 265                 270         


Lys Lys Ala Leu Glu Val Thr Pro Thr Ser Ser Phe Leu His His Gln 
        275                 280                 285             


Met Gly Leu Cys Tyr Arg Ala Gln Met Ile Gln Ile Lys Lys Ala Thr 
    290                 295                 300                 


His Asn Arg Pro Lys Gly Lys Asp Lys Leu Lys Val Asp Glu Leu Ile 
305                 310                 315                 320 


Ser Ser Ala Ile Phe His Phe Lys Ala Ala Met Glu Arg Asp Ser Met 
                325                 330                 335     


Phe Ala Phe Ala Tyr Thr Asp Leu Ala Asn Met Tyr Ala Glu Gly Gly 
            340                 345                 350         


Gln Tyr Ser Asn Ala Glu Asp Ile Phe Arg Lys Ala Leu Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Asp Asp His Lys His Gln Ile His Tyr His Tyr Gly Arg 
    370                 375                 380                 


Phe Gln Glu Phe His Arg Lys Ser Glu Asn Thr Ala Ile His His Tyr 
385                 390                 395                 400 


Leu Glu Ala Leu Lys Val Lys Asp Arg Ser Pro Leu Arg Thr Lys Leu 
                405                 410                 415     


Thr Ser Ala Leu Lys Lys Leu Ser Thr Lys Arg Leu Cys His Asn Ala 
            420                 425                 430         


Leu Asp Val Gln Ser Leu Ser Ala Leu Gly Phe Val Tyr Lys Leu Glu 
        435                 440                 445             


Gly Glu Lys Arg Gln Ala Ala Glu Tyr Tyr Glu Lys Ala Gln Lys Ile 
    450                 455                 460                 


Asp Pro Glu Asn Ala Glu Phe Leu Thr Ala Leu Cys Glu Leu Arg Leu 
465                 470                 475                 480 


Ser Ile 
        


<210>  11
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Thr Lys Thr Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Thr Asn Asp Thr Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Thr Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Thr Asn Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln 
385                 390                 395                 400 


His Phe Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu 
                405                 410                 415     


Glu Ile Thr Glu Lys Arg His Gly Thr Leu Val Trp Asp Thr Glu Val 
            420                 425                 430         


Lys Pro Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe 
        435                 440                 445             


Ser Gly Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg 
    450                 455                 460                 


Met Gly Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val 
465                 470                 475                 480 


Leu Thr Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Thr Arg Gln 
                485                 490                 495     


Ser Lys Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu 
            500                 505                 510         


Ala Leu Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu 
        515                 520                 525             


Val Ser Tyr Leu Arg Gln Gln Asn Leu 
    530                 535         


<210>  12
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Gln Pro Thr Arg Pro Ser Val Thr Cys Asp Gln Gly Ser Ser 
1               5                   10                  15      


Thr Ile Gly Gly Thr Ala Ala Gln Ala Thr Thr Ser Ser Ser Ala Thr 
            20                  25                  30          


Ser Gly Ser Asn Tyr Gln Arg Asp Arg Leu Gly Arg Arg Pro Glu Ile 
        35                  40                  45              


Gly Val Gly Gly Gln Pro Gln Ile Cys Phe Pro Arg Pro Arg Ser Ala 
    50                  55                  60                  


Gln Gln Pro Val Leu Phe Ser Leu Met Asn Ser Ser Glu Ala Ala Met 
65                  70                  75                  80  


Lys Lys Thr Leu Pro Lys Ser His Leu Ser Arg Val Ile Ile His Asp 
                85                  90                  95      


Asn Arg Ile Thr Gln Arg Ile Tyr Glu Met Glu Val Ser Ala Leu Glu 
            100                 105                 110         


Lys Thr Lys Lys Lys Ile Ser His Tyr Tyr Glu His Leu Lys Lys Lys 
        115                 120                 125             


Phe Met Thr Glu Gln Leu Arg Lys Leu Gly Arg Trp Arg Glu Glu Ser 
    130                 135                 140                 


Val Asn Ser Asn Arg Tyr Leu Thr Phe Gly Ile Pro Pro Pro Val 
145                 150                 155                 


