                         SEQUENCE LISTING

<110>  LaThangue, Nicholas
 
<120>  Cancer Therapy by Modifying Neoantigen Expression

<130>  P47909WO

<140>  PCT/GB20/nnnnnn
<141>  2020-04-24

<150>  GB1905780.1
<151>  2019-04-25

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Met Ala Val Gly Gly Ala Gly Gly Ser Arg Val Ser Ser 
1               5                   10                  15      


Gly Arg Asp Leu Asn Cys Val Pro Glu Ile Ala Asp Thr Leu Gly Ala 
            20                  25                  30          


Val Ala Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro 
        35                  40                  45              


Arg Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly 
    50                  55                  60                  


Pro Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr 
65                  70                  75                  80  


Leu Ile Val Gly Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val 
                85                  90                  95      


Glu Lys Ile Arg Arg Asn Ser Glu Ala Ala Met Leu Gln Glu Leu Asn 
            100                 105                 110         


Phe Gly Ala Tyr Leu Gly Leu Pro Ala Phe Leu Leu Pro Leu Asn Gln 
        115                 120                 125             


Glu Asp Asn Thr Asn Leu Ala Arg Val Leu Thr Asn His Ile His Thr 
    130                 135                 140                 


Gly His His Ser Ser Met Phe Trp Met Arg Val Pro Leu Val Ala Pro 
145                 150                 155                 160 


Glu Asp Leu Arg Asp Asp Ile Ile Glu Asn Ala Pro Thr Thr His Thr 
                165                 170                 175     


Glu Glu Tyr Ser Gly Glu Glu Lys Thr Trp Met Trp Trp His Asn Phe 
            180                 185                 190         


Arg Thr Leu Cys Asp Tyr Ser Lys Arg Ile Ala Val Ala Leu Glu Ile 
        195                 200                 205             


Gly Ala Asp Leu Pro Ser Asn His Val Ile Asp Arg Trp Leu Gly Glu 
    210                 215                 220                 


Pro Ile Lys Ala Ala Ile Leu Pro Thr Ser Ile Phe Leu Thr Asn Lys 
225                 230                 235                 240 


Lys Gly Phe Pro Val Leu Ser Lys Met His Gln Arg Leu Ile Phe Arg 
                245                 250                 255     


Leu Leu Lys Leu Glu Val Gln Phe Ile Ile Thr Gly Thr Asn His His 
            260                 265                 270         


Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr Leu Glu Tyr Leu Ser 
        275                 280                 285             


Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu Phe Ala Lys Gly Tyr 
    290                 295                 300                 


Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu Met Asp Asn Leu Glu 
305                 310                 315                 320 


Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro Ile Lys Tyr Ser Gln 
                325                 330                 335     


Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp Arg Val Pro Glu Glu 
            340                 345                 350         


Glu Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg 
        355                 360                 365             


Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala Lys Gln Ala Asp Arg 
    370                 375                 380                 


Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro Asn Ala Val Val Thr 
385                 390                 395                 400 


Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser Gln Val Thr Val Val 
                405                 410                 415     


Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu Lys Ala Asp Ile Ile 
            420                 425                 430         


Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn Glu Leu Ser Pro Glu 
        435                 440                 445             


Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp Asp Gly Val Ser Ile 
    450                 455                 460                 


Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile Ser Ser Ser Lys Leu 
465                 470                 475                 480 


Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys Asp Arg Asp Pro Glu Ala 
                485                 490                 495     


Gln Phe Glu Met Pro Tyr Val Val Arg Leu His Asn Phe His Gln Leu 
            500                 505                 510         


Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser His Pro Asn Arg Asp Pro 
        515                 520                 525             


Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu Phe Pro Val Glu Val 
    530                 535                 540                 


Asn Thr Val Leu His Gly Phe Ala Gly Tyr Phe Glu Thr Val Leu Tyr 
545                 550                 555                 560 


Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr His Ser Pro Gly Met 
                565                 570                 575     


Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys Gln Pro Ile Thr Val 
            580                 585                 590         


Arg Glu Gly Gln Thr Ile Cys Val Arg Phe Trp Arg Cys Ser Asn Ser 
        595                 600                 605             


Lys Lys Val Trp Tyr Glu Trp Ala Val Thr Ala Pro Val Cys Ser Ala 
    610                 615                 620                 


Ile His Asn Pro Thr Gly Arg Ser Tyr Thr Ile Gly Leu 
625                 630                 635         


<210>  2
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  2
ccgcuauugc accuuggaa                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  3
caacagagau ccuaugauu                                                    19


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<400>  4

Arg Gly Arg Gly Arg 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  METHYLATION

<400>  5

Cys Glu Ser Ser Gly Pro Ala Arg Gly Arg Gly Arg His Pro Gly Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Gly Arg Gly Arg 
1               5   


<210>  7
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  7
cuccucgcag aucgucaucu u                                                 21


<210>  8
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Leu Ala Gly Ala Pro Ala Gly Gly Pro Cys Ala Pro Ala Leu 
1               5                   10                  15      


Glu Ala Leu Leu Gly Ala Gly Ala Leu Arg Leu Leu Asp Ser Ser Gln 
            20                  25                  30          


Ile Val Ile Ile Ser Ala Ala Gln Asp Ala Ser Ala Pro Pro Ala Pro 
        35                  40                  45              


Thr Gly Pro Ala Ala Pro Ala Ala Gly Pro Cys Asp Pro Asp Leu Leu 
    50                  55                  60                  


Leu Phe Ala Thr Pro Gln Ala Pro Arg Pro Thr Pro Ser Ala Pro Arg 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Pro Pro Val Lys Arg Arg Leu Asp Leu Glu Thr 
                85                  90                  95      


Asp His Gln Tyr Leu Ala Glu Ser Ser Gly Pro Ala Arg Gly Arg Gly 
            100                 105                 110         


Arg His Pro Gly Lys Gly Val Lys Ser Pro Gly Glu Lys Ser Arg Tyr 
        115                 120                 125             


Glu Thr Ser Leu Asn Leu Thr Thr Lys Arg Phe Leu Glu Leu Leu Ser 
    130                 135                 140                 


His Ser Ala Asp Gly Val Val Asp Leu Asn Trp Ala Ala Glu Val Leu 
145                 150                 155                 160 


Lys Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu Glu Gly 
                165                 170                 175     


Ile Gln Leu Ile Ala Lys Lys Ser Lys Asn His Ile Gln Trp Leu Gly 
            180                 185                 190         


Ser His Thr Thr Val Gly Val Gly Gly Arg Leu Glu Gly Leu Thr Gln 
        195                 200                 205             


Asp Leu Arg Gln Leu Gln Glu Ser Glu Gln Gln Leu Asp His Leu Met 
    210                 215                 220                 


Asn Ile Cys Thr Thr Gln Leu Arg Leu Leu Ser Glu Asp Thr Asp Ser 
225                 230                 235                 240 


Gln Arg Leu Ala Tyr Val Thr Cys Gln Asp Leu Arg Ser Ile Ala Asp 
                245                 250                 255     


Pro Ala Glu Gln Met Val Met Val Ile Lys Ala Pro Pro Glu Thr Gln 
            260                 265                 270         


Leu Gln Ala Val Asp Ser Ser Glu Asn Phe Gln Ile Ser Leu Lys Ser 
        275                 280                 285             


Lys Gln Gly Pro Ile Asp Val Phe Leu Cys Pro Glu Glu Thr Val Gly 
    290                 295                 300                 


Gly Ile Ser Pro Gly Lys Thr Pro Ser Gln Glu Val Thr Ser Glu Glu 
305                 310                 315                 320 


Glu Asn Arg Ala Thr Asp Ser Ala Thr Ile Val Ser Pro Pro Pro Ser 
                325                 330                 335     


Ser Pro Pro Ser Ser Leu Thr Thr Asp Pro Ser Gln Ser Leu Leu Ser 
            340                 345                 350         


Leu Glu Gln Glu Pro Leu Leu Ser Arg Met Gly Ser Leu Arg Ala Pro 
        355                 360                 365             


Val Asp Glu Asp Arg Leu Ser Pro Leu Val Ala Ala Asp Ser Leu Leu 
    370                 375                 380                 


Glu His Val Arg Glu Asp Phe Ser Gly Leu Leu Pro Glu Glu Phe Ile 
385                 390                 395                 400 


Ser Leu Ser Pro Pro His Glu Ala Leu Asp Tyr His Phe Gly Leu Glu 
                405                 410                 415     


Glu Gly Glu Gly Ile Arg Asp Leu Phe Asp Cys Asp Phe Gly Asp Leu 
            420                 425                 430         


Thr Pro Leu Asp Phe 
        435         


<210>  9
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  9
agcugacccu gaaguucuu                                                    19


<210>  10
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  10
aaggagcgau cugcuagcua c                                                 21


<210>  11
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  11
gaaguaagac aguagauga                                                    19


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Ala Arg Gly Arg Gly Arg His Pro Gly Lys Gly 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Ala Lys Gly Arg Gly Arg His Pro Gly Lys Gly 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Ala Arg Gly Lys Gly Lys His Pro Gly Lys Gly 
1               5                   10          


