                         SEQUENCE LISTING

<110>  UNIVERSITY OF WASHINGTON
 
<120>  De Novo Design of Tunable pH-Driven Conformational Switches

<130>  18-1784-PCT (UW 48290.02WO2)

<150>  US 62/835,651
<151>  2019-04-18

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu His Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  2
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala Thr 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Ala 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu His Asn Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  3
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Leu Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu Val Leu 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  4
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala Leu 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Ala 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu Val Leu Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  5
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Leu Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Leu Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Ile Val Glu 
    50                  55                  60                  


Ala Ile Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu Val Leu 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  6
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala Leu 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Leu Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Ile Val Glu Ala Ile Arg Ala 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu Val Leu Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  7
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ser Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu Asn Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  8
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ser Thr 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Ala 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu Asn Asn Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  9
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ser Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


Asn Asn Arg Leu Ile Val Glu His Asn Ala Ile Ile Val Glu His Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  10
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala Thr 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ser Thr Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu His Asn Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  11
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ser Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ser Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


Asn Asn Arg Leu Ile Val Glu His Asn Ala Ile Ile Val Glu Asn Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  12
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ser Thr 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ser Thr Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu Asn Asn Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  13
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Thr Leu Lys Glu Val Leu Glu Arg Leu Glu 
            20                  25                  30          


Glu Val Leu Arg Arg His Arg Glu Val Ala Arg Glu His Gln Arg Trp 
        35                  40                  45              


Ala Arg Glu His Glu Gln Trp Val Arg Asp Asp Pro Asn Ser Ala Lys 
    50                  55                  60                  


Trp Ile Ala Glu Ser Thr Arg Trp Ile Leu Glu Thr Thr Asp Ala Ile 
65                  70                  75                  80  


Ser Arg Thr Ala Asp Val Leu Ala Glu Ala Ile Arg Val Leu Ala Glu 
                85                  90                  95      


Ser Asp 
        


<210>  14
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gly Ser His Met Gly Thr Leu Lys Glu Val Leu Glu Arg Leu Glu Glu 
1               5                   10                  15      


Val Leu Arg Arg His Arg Glu Val Ala Arg Glu His Gln Arg Trp Ala 
            20                  25                  30          


Arg Glu His Glu Gln Trp Val Arg Asp Asp Pro Asn Ser Ala Lys Trp 
        35                  40                  45              


Ile Ala Glu Ser Thr Arg Trp Ile Leu Glu Thr Thr Asp Ala Ile Ser 
    50                  55                  60                  


Arg Thr Ala Asp Val Leu Ala Glu Ala Ile Arg Val Leu Ala Glu Ser 
65                  70                  75                  80  


Asp 
    


<210>  15
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


Asn Asn Arg Ala Ile Val Glu Asn Asn Ala Ile Ile Val Glu Asn Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  16
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg 
        35                  40                  45              


Ala Ile Val Glu Asn Asn Ala Ile Ile Val Glu Asn Asn Arg Ile Ile 
    50                  55                  60                  


Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75      


<210>  17
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


His Asn Arg Ala Ile Val Glu His Asn Ala Ile Val Val Glu His Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  18
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg 
        35                  40                  45              


Ala Ile Val Glu His Asn Ala Ile Val Val Glu His Asn Arg Ile Ile 
    50                  55                  60                  


Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75      


<210>  19
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


His Asn Arg Ala Ile Val Glu His Asn Met Ile Ile Val Glu His Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  20
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg 
        35                  40                  45              


Ala Ile Val Glu His Asn Met Ile Ile Val Glu His Asn Arg Ile Ile 
    50                  55                  60                  


Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75      


<210>  21
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu His Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Asn Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  22
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg 
        35                  40                  45              


Ala Ile Val Glu His Asn Ala Ile Ile Val Glu His Asn Arg Ile Ile 
    50                  55                  60                  


Ala Ala Val Leu Glu Leu Asn Val Arg Ala Ile Lys 
65                  70                  75      


<210>  23
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Leu Arg 
            20                  25                  30          


Glu Leu Lys Lys Ala Thr Ala Ala Leu Glu Arg Ala Thr Ala Glu Leu 
        35                  40                  45              


Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile 
    50                  55                  60                  


Ala Ala His Asn Lys Ile Ile Ala Glu Val Leu Arg Ile Ile Ala Lys 
65                  70                  75                  80  


Val Leu Lys 
            


<210>  24
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys 
1               5                   10                  15      


Lys Ala Thr Ala Ala Leu Glu Arg Ala Thr Ala Glu Leu Lys Lys Asn 
            20                  25                  30          


Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala Ala His 
        35                  40                  45              


Asn Lys Ile Ile Ala Glu Val Leu Arg Ile Ile Ala Lys Val Leu Lys 
    50                  55                  60                  


<210>  25
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg 
            20                  25                  30          


Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu 
        35                  40                  45              


Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile 
    50                  55                  60                  


Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys 
65                  70                  75                  80  


Val Leu Lys 
            


<210>  26
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys 
1               5                   10                  15      


Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn 
            20                  25                  30          


Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala Glu His 
        35                  40                  45              


Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys Val Leu Lys 
    50                  55                  60                  


<210>  27
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Asp Glu Glu Asp His Leu Lys Lys Leu Lys Thr His Leu Glu Lys 
1               5                   10                  15      


Leu Glu Arg His Leu Lys Leu Leu Glu Asp His Ala Lys Lys Leu Glu 
            20                  25                  30          


Asp Ile Leu Lys Glu Arg Pro Glu Asp Ser Ala Val Lys Glu Ser Ile 
        35                  40                  45              


Asp Glu Leu Arg Arg Ser Ile Glu Leu Val Arg Glu Ser Ile Glu Ile 
    50                  55                  60                  


Phe Arg Gln Ser Val Glu Glu Glu Glu Gly Ser Ser His His His His 
65                  70                  75                  80  


His His Ser Ser Gly Glu Asn Leu Tyr Phe Gln Gly Asp Val Lys Glu 
                85                  90                  95      


Leu Thr Lys Ile Leu Asp Thr Leu Thr Lys Ile Leu Glu Thr Ala Thr 
            100                 105                 110         


Lys Val Ile Lys Asp Ala Thr Lys Leu Leu Glu Glu His Arg Lys Ser 
        115                 120                 125             


Asp Lys Pro Asp Pro Arg Leu Ile Glu Thr His Lys Lys Leu Val Glu 
    130                 135                 140                 


Glu His Glu Thr Leu Val Arg Gln His Lys Glu Leu Ala Glu Glu His 
145                 150                 155                 160 


Leu Lys Arg Thr Arg 
                165 


<210>  28
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Asp Glu Glu Asp His Leu Lys Lys Leu Lys Thr His Leu Glu Lys 
1               5                   10                  15      


Leu Glu Arg His Leu Lys Leu Leu Glu Asp His Ala Lys Lys Leu Glu 
            20                  25                  30          


Asp Ile Leu Lys Glu Arg Pro Glu Asp Ser Ala Val Lys Glu Ser Ile 
        35                  40                  45              


Asp Glu Leu Arg Arg Ser Ile Glu Leu Val Arg Glu Ser Ile Glu Ile 
    50                  55                  60                  


Phe Arg Gln Ser Val Glu Glu Glu Glu Gly Asp Val Lys Glu Leu Thr 
65                  70                  75                  80  


Lys Ile Leu Asp Thr Leu Thr Lys Ile Leu Glu Thr Ala Thr Lys Val 
                85                  90                  95      


Ile Lys Asp Ala Thr Lys Leu Leu Glu Glu His Arg Lys Ser Asp Lys 
            100                 105                 110         


Pro Asp Pro Arg Leu Ile Glu Thr His Lys Lys Leu Val Glu Glu His 
        115                 120                 125             


Glu Thr Leu Val Arg Gln His Lys Glu Leu Ala Glu Glu His Leu Lys 
    130                 135                 140                 


Arg Thr Arg 
145         


<210>  29
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Met Asp Glu Glu Asp His Leu Lys Lys Leu Lys Thr His Leu Glu Lys 
1               5                   10                  15      


Leu Glu Arg His Leu Lys Leu Ala Glu Asp His Ala Lys Lys Leu Glu 
            20                  25                  30          


Asp Ile Leu Lys Glu Arg Pro Glu Asp Ser Ala Val Lys Glu Ser Ile 
        35                  40                  45              


Asp Glu Leu Arg Arg Ser Ile Glu Leu Val Arg Glu Ser Ile Glu Ile 
    50                  55                  60                  


Phe Arg Gln Ser Val Glu Glu Glu Glu Gly Ser Ser His His His His 
65                  70                  75                  80  


His His Ser Ser Gly Glu Asn Leu Tyr Phe Gln Gly Asp Val Lys Glu 
                85                  90                  95      


Leu Thr Lys Ile Leu Asp Thr Leu Thr Lys Ile Leu Glu Thr Ala Thr 
            100                 105                 110         


Lys Val Ile Lys Asp Ala Thr Lys Leu Leu Glu Glu His Arg Lys Ser 
        115                 120                 125             


Asp Lys Pro Asp Pro Arg Leu Ile Glu Thr His Lys Lys Leu Val Glu 
    130                 135                 140                 


Glu His Glu Thr Leu Ala Arg Gln His Lys Glu Leu Ala Glu Glu His 
145                 150                 155                 160 


Leu Lys Arg Thr Arg 
                165 


<210>  30
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Met Asp Glu Glu Asp His Leu Lys Lys Leu Lys Thr His Leu Glu Lys 
1               5                   10                  15      


Leu Glu Arg His Leu Lys Leu Ala Glu Asp His Ala Lys Lys Leu Glu 
            20                  25                  30          


Asp Ile Leu Lys Glu Arg Pro Glu Asp Ser Ala Val Lys Glu Ser Ile 
        35                  40                  45              


Asp Glu Leu Arg Arg Ser Ile Glu Leu Val Arg Glu Ser Ile Glu Ile 
    50                  55                  60                  


Phe Arg Gln Ser Val Glu Glu Glu Glu Gly Asp Val Lys Glu Leu Thr 
65                  70                  75                  80  


Lys Ile Leu Asp Thr Leu Thr Lys Ile Leu Glu Thr Ala Thr Lys Val 
                85                  90                  95      


Ile Lys Asp Ala Thr Lys Leu Leu Glu Glu His Arg Lys Ser Asp Lys 
            100                 105                 110         


Pro Asp Pro Arg Leu Ile Glu Thr His Lys Lys Leu Val Glu Glu His 
        115                 120                 125             


Glu Thr Leu Ala Arg Gln His Lys Glu Leu Ala Glu Glu His Leu Lys 
    130                 135                 140                 


Arg Thr Arg 
145         


<210>  31
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Thr Lys Glu Asp Ile Leu Glu Arg Gln Arg Lys Ile Ile Glu Arg 
1               5                   10                  15      


Ala Gln Glu Ile His Arg Arg Gln Gln Glu Ile Leu Lys Glu Gln Glu 
            20                  25                  30          


Lys Ile Ile Arg Lys Pro Gly Ser Ser Glu Glu Ala Met Lys Arg Ser 
        35                  40                  45              


Leu Lys Leu Ile Glu Glu Ser Leu Arg Leu Leu Lys Glu Leu Leu Glu 
    50                  55                  60                  


Leu Ser Glu Glu Ser Ala Gln Leu Leu Tyr Glu Gln Arg Gly Ser Ser 
65                  70                  75                  80  


His His His His His His Ser Ser Gly Glu Asn Leu Tyr Phe Gln Gly 
                85                  90                  95      


Thr Glu Lys Arg Leu Leu Glu Glu Ala Glu Arg Ala His Arg Glu Gln 
            100                 105                 110         


Lys Glu Ile Ile Lys Lys Ala Gln Glu Leu His Lys Glu Leu Thr Lys 
        115                 120                 125             


Ile His Gln Gln Ser Gly Ser Ser Glu Glu Ala Lys Lys Arg Ala Leu 
    130                 135                 140                 


Lys Ile Ser Gln Glu Ile Arg Glu Leu Ser Lys Arg Ser Leu Glu Leu 
145                 150                 155                 160 


Leu Arg Glu Ile Leu Tyr Leu Ser Gln Glu Gln Lys 
                165                 170         


<210>  32
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Thr Lys Glu Asp Ile Leu Glu Arg Gln Arg Lys Ile Ile Glu Arg 
1               5                   10                  15      


Ala Gln Glu Ile His Arg Arg Gln Gln Glu Ile Leu Lys Glu Gln Glu 
            20                  25                  30          


Lys Ile Ile Arg Lys Pro Gly Ser Ser Glu Glu Ala Met Lys Arg Ser 
        35                  40                  45              


Leu Lys Leu Ile Glu Glu Ser Leu Arg Leu Leu Lys Glu Leu Leu Glu 
    50                  55                  60                  


Leu Ser Glu Glu Ser Ala Gln Leu Leu Tyr Glu Gln Arg Gly Thr Glu 
65                  70                  75                  80  


Lys Arg Leu Leu Glu Glu Ala Glu Arg Ala His Arg Glu Gln Lys Glu 
                85                  90                  95      


Ile Ile Lys Lys Ala Gln Glu Leu His Lys Glu Leu Thr Lys Ile His 
            100                 105                 110         


Gln Gln Ser Gly Ser Ser Glu Glu Ala Lys Lys Arg Ala Leu Lys Ile 
        115                 120                 125             


Ser Gln Glu Ile Arg Glu Leu Ser Lys Arg Ser Leu Glu Leu Leu Arg 
    130                 135                 140                 


Glu Ile Leu Tyr Leu Ser Gln Glu Gln Lys 
145                 150                 


<210>  33
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ala Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Gly Gly Ser Gly Ser Gly Ser Glu Asp 
    50                  55                  60                  


Ala Leu Val Glu His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile 
65                  70                  75                  80  


Val Glu His Asn Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg 
                85                  90                  95      


Ala Ile Lys 
            


<210>  34
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ala 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Gly Gly Ser Gly Ser Gly Ser Glu Asp Ala Leu Val 
        35                  40                  45              


Glu His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu His 
    50                  55                  60                  


Asn Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75                  80  


<210>  35
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ser Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ile Thr Glu Glu Leu Lys Lys Gly Gly Ser Gly Ser Gly Ser Glu Asp 
    50                  55                  60                  


Ala Leu Val Glu His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile 
65                  70                  75                  80  


Val Glu Asn Asn Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg 
                85                  90                  95      


Ala Ile Lys 
            


<210>  36
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ser 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ile Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Gly Gly Ser Gly Ser Gly Ser Glu Asp Ala Leu Val 
        35                  40                  45              


Glu His Asn Arg Ala Ile Val Glu His Asn Ala Ile Ile Val Glu Asn 
    50                  55                  60                  


Asn Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75                  80  


<210>  37
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Gly Ser Glu Glu Glu Ile Lys Arg Leu Leu Glu Glu Leu Arg Lys Ser 
1               5                   10                  15      


Ser Glu Glu Leu Arg Arg Ile Thr Lys Glu Leu Asp Asp Leu Ser Lys 
            20                  25                  30          


Glu Leu Arg Val Gly Gly Ser Gly Ser Gly Ser Glu Met Leu Val Glu 
        35                  40                  45              


His Asn Lys Leu Ile Ser Glu His Asn Arg Ile Ile Val Glu Asn Asn 
    50                  55                  60                  


Arg Ile Ile Val Glu Ile Leu Glu Ala Ile Ala Arg Val Gly Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Val Glu Val Glu Arg Ile Leu Asp Glu Leu Arg Lys 
                85                  90                  95      


Ser Ser Glu Glu Leu Asp Arg Val Thr Lys Glu Leu Lys Lys Leu Thr 
            100                 105                 110         


Glu Glu Leu Asp Val Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser 
        115                 120                 125             


Gly Ser Val Glu Ala Leu Val Arg His Asn Val Leu Ile Thr Arg His 
    130                 135                 140                 


Asn Asp Ile Ile Val Lys Asn Asn Asp Ile Ile Asn Lys Ile Leu Lys 
145                 150                 155                 160 


Leu Ile Ala Glu Ala Val Gly Gly Ser Gly Ser Gly Ser Glu Leu Glu 
                165                 170                 175     


Arg Ile Leu Arg Glu Leu Glu Glu Ser Thr Lys Glu Leu Arg Lys Ala 
            180                 185                 190         


Thr Glu Glu Leu Arg Arg Leu Ser Glu Glu Leu Lys Val Gly Gly Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Glu Ala Leu Val Arg His Asn Glu Ala Ile Val 
    210                 215                 220                 


Glu His Asn Lys Ile Ile Val Lys Asn Asn Asp Ile Ile Val Lys Ile 
225                 230                 235                 240 


Leu Glu Leu Ile Thr Glu Arg Ile 
                245             


<210>  38
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Gly Ser Glu Glu Glu Ile Lys Arg Leu Leu Glu Glu Leu Arg Lys Ser 
1               5                   10                  15      


Ser Glu Glu Leu Arg Arg Ile Thr Lys Glu Leu Asp Asp Leu Ser Lys 
            20                  25                  30          


Glu Leu Arg Val Gly Gly Ser Gly Ser Gly Ser Glu Met Leu Val Glu 
        35                  40                  45              


His Asn Lys Leu Ile Ser Glu His Asn Arg Ile Ile Val Glu Asn Asn 
    50                  55                  60                  


Arg Ile Ile Val Glu Ile Leu Glu Ala Ile Ala Arg Val Gly Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Val Glu Val Glu Arg Ile Leu Asp Glu Leu Arg Lys 
                85                  90                  95      


Ser Ser Glu Glu Leu Asp Arg Val Thr Lys Glu Leu Lys Lys Leu Thr 
            100                 105                 110         


Glu Glu Leu Asp Val Gly Gly Ser Gly Ser Gly Ser Val Glu Ala Leu 
        115                 120                 125             


Val Arg His Asn Val Leu Ile Thr Arg His Asn Asp Ile Ile Val Lys 
    130                 135                 140                 


Asn Asn Asp Ile Ile Asn Lys Ile Leu Lys Leu Ile Gly Glu Ala Val 
145                 150                 155                 160 


Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly Ser Glu Phe Glu 
                165                 170                 175     


Arg Trp Leu Arg Gln Leu Glu Glu Ser Thr Lys Glu Leu Arg Lys Phe 
            180                 185                 190         


Thr Glu Glu Leu Arg Arg Phe Ser Glu Glu Leu Lys Val Gly Gly Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Glu Ala Leu Val Arg His Asn Glu Ala Ile Val 
    210                 215                 220                 


Glu His Asn Lys Ala Ile Val Lys Asn Asn Asp Ile Ile Val Lys Ile 
225                 230                 235                 240 


Leu Glu Leu Val Thr Glu Arg Ile 
                245             


<210>  39
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Gly Ser Glu Glu Glu Ile Lys Arg Leu Leu Glu Glu Leu Arg Lys Ser 
1               5                   10                  15      


Ser Glu Glu Leu Arg Arg Ile Thr Lys Glu Leu Asp Asp Leu Ser Lys 
            20                  25                  30          


Glu Leu Arg Val Gly Gly Ser Gly Ser Gly Ser Leu Val Pro Arg Gly 
        35                  40                  45              


Ser Gly Ser Gly Ser Gly Ser His Ala Leu Val Glu His Asn Lys Leu 
    50                  55                  60                  


Ile Ser Glu His Asn Arg Ile Val Val Glu Asn Asn Arg Ile Ile Val 
65                  70                  75                  80  


Glu Ile Leu Glu Ala Ile Ala Arg Val Gly Gly Ser Gly Ser Gly Ser 
                85                  90                  95      


Val Glu Val Glu Arg Ile Leu Asp Glu Leu Arg Lys Ser Ser Glu Glu 
            100                 105                 110         


Leu Asp Arg Val Thr Lys Glu Leu Lys Lys Leu Thr Glu Glu Leu Asp 
        115                 120                 125             


Val Gly Gly Ser Gly Ser Gly Ser Leu Val Pro Arg Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Val Glu Ala Leu Val Arg His Asn Val Leu Ile Thr 
145                 150                 155                 160 


Arg His Asn Asp Ile Val Val Lys Asn Asn Asp Ile Ile Asn Lys Ile 
                165                 170                 175     


Leu Lys Leu Ile Ala Glu Ala Val Gly Gly Ser Gly Ser Gly Ser Glu 
            180                 185                 190         


Leu Glu Arg Ile Leu Arg Glu Leu Glu Glu Ser Thr Lys Glu Leu Arg 
        195                 200                 205             


Lys Ala Thr Glu Glu Leu Arg Arg Leu Ser Glu Glu Leu Lys Val Gly 
    210                 215                 220                 


Gly Ser Gly Ser Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Ser His Glu Ala Leu Val Arg His Asn Glu Ala Ile Val Glu His 
                245                 250                 255     


Asn Lys Ile Val Val Lys Asn Asn Asp Ile Ile Val Lys Ile Leu Glu 
            260                 265                 270         


Leu Ile Thr Glu Arg Ile 
        275             


<210>  40
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Gly Ser Glu Glu Glu Ile Lys Arg Leu Leu Glu Glu Leu Arg Lys Ala 
1               5                   10                  15      


Leu Glu Glu Leu Arg Arg Ile Thr Lys Glu Leu Asp Asp Leu Ser Lys 
            20                  25                  30          


Glu Leu Arg Val Gly Gly Ser Gly Ser Gly Ser Leu Val Pro Arg Gly 
        35                  40                  45              


Ser Gly Ser Gly Ser Gly Ser His Ala Leu Val Glu His Asn Lys Leu 
    50                  55                  60                  


Ile Ser Glu His Asn Arg Ile Val Val Glu Val Leu Arg Ile Ile Ala 
65                  70                  75                  80  


Glu Ile Leu Glu Ala Ile Ala Arg Val Gly Gly Ser Gly Ser Gly Ser 
                85                  90                  95      


Val Glu Val Glu Arg Ile Leu Asp Glu Leu Arg Lys Ala Leu Glu Glu 
            100                 105                 110         


Leu Asp Arg Val Thr Lys Glu Leu Lys Lys Leu Thr Glu Glu Leu Asp 
        115                 120                 125             


Val Gly Gly Ser Gly Ser Gly Ser Leu Val Pro Arg Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Val Glu Ala Leu Val Arg His Asn Val Leu Ile Thr 
145                 150                 155                 160 


Arg His Asn Asp Ile Val Val Lys Val Leu Asp Ile Ile Ala Lys Ile 
                165                 170                 175     


Leu Lys Leu Ile Ala Glu Ala Val Gly Gly Ser Gly Ser Gly Ser Glu 
            180                 185                 190         


Leu Glu Arg Ile Leu Arg Glu Leu Glu Glu Ala Leu Lys Glu Leu Arg 
        195                 200                 205             


Lys Ala Thr Glu Glu Leu Arg Arg Leu Ser Glu Glu Leu Lys Val Gly 
    210                 215                 220                 


Gly Ser Gly Ser Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Ser His Glu Ala Leu Val Arg His Asn Glu Ala Ile Val Glu His 
                245                 250                 255     


Asn Lys Ile Val Val Lys Val Leu Asp Ile Ile Ala Lys Ile Leu Glu 
            260                 265                 270         


Leu Ile Thr Glu Arg Ile 
        275             


<210>  41
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Ser Asp Glu Leu Lys Tyr Glu Leu Glu Lys 
            20                  25                  30          


Ser Thr Arg Glu Leu Gln Lys Ser Thr Asp Glu Leu Glu Lys Ser Thr 
        35                  40                  45              


Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp Val Leu Val Glu Asn Asn 
    50                  55                  60                  


Glu Leu Ile Val Arg Asn Asn Lys Ile Ile Val Lys Asn Asn Ile Ile 
65                  70                  75                  80  


Ile Val Arg Thr Glu Lys Lys Gly Ser Gly Gly Ser Gly Asp Glu Leu 
                85                  90                  95      


Lys Glu Glu Leu Glu Lys Ser Thr Arg Glu Leu Asp Lys Ser Thr Lys 
            100                 105                 110         


Lys Leu Glu Arg Ser Thr Glu Glu Leu Lys Arg Asn Pro Ser Lys Asp 
        115                 120                 125             


Ala Leu Val Glu Asn Asn Lys Leu Ile Val Glu Asn Asn Thr Ile Ile 
    130                 135                 140                 


Val Arg Asn Asn Asp Ile Ile Val Arg Thr Arg Lys Lys Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu Glu Lys Ser Thr Arg Glu 
                165                 170                 175     


Leu Lys Lys Ser Thr Lys Glu Leu Gln Lys Ser Thr Glu Glu Leu Glu 
            180                 185                 190         


Arg Asn Pro Ser Lys Asp Ala Leu Val Lys Asn Asn Lys Leu Ile Ala 
        195                 200                 205             


Asp Asn Asn Arg Ile Ile Val Arg Asn Asn Thr Ile Ile Val Arg Asp 
    210                 215                 220                 


Ile Lys Ala Ser 
225             


<210>  42
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

His Met Gly Ser Asp Glu Leu Lys Tyr Glu Leu Glu Lys Ser Thr Arg 
1               5                   10                  15      


Glu Leu Gln Lys Ser Thr Asp Glu Leu Glu Lys Ser Thr Glu Glu Leu 
            20                  25                  30          


Glu Arg Asn Pro Ser Lys Asp Val Leu Val Glu Asn Asn Glu Leu Ile 
        35                  40                  45              


Val Arg Asn Asn Lys Ile Ile Val Lys Asn Asn Ile Ile Ile Val Arg 
    50                  55                  60                  


Thr Glu Lys Lys Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys Glu Glu 
65                  70                  75                  80  


Leu Glu Lys Ser Thr Arg Glu Leu Asp Lys Ser Thr Lys Lys Leu Glu 
                85                  90                  95      


Arg Ser Thr Glu Glu Leu Lys Arg Asn Pro Ser Lys Asp Ala Leu Val 
            100                 105                 110         


Glu Asn Asn Lys Leu Ile Val Glu Asn Asn Thr Ile Ile Val Arg Asn 
        115                 120                 125             


Asn Asp Ile Ile Val Arg Thr Arg Lys Lys Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Asp Glu Leu Lys Glu Glu Leu Glu Lys Ser Thr Arg Glu Leu Lys Lys 
145                 150                 155                 160 


Ser Thr Lys Glu Leu Gln Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro 
                165                 170                 175     


Ser Lys Asp Ala Leu Val Lys Asn Asn Lys Leu Ile Ala Asp Asn Asn 
            180                 185                 190         


Arg Ile Ile Val Arg Asn Asn Thr Ile Ile Val Arg Asp Ile Lys Ala 
        195                 200                 205             


Ser 
    


<210>  43
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Ser Asp Asp Glu Asp Ile Asp Arg Val Leu 
            20                  25                  30          


Glu Glu Leu Arg Arg Ser Thr Glu Glu Leu Asp Arg Ser Thr Lys Asp 
        35                  40                  45              


Leu Glu Arg Ser Thr Gln Glu Leu Arg Arg Asn Pro Ser Val Asp Ala 
    50                  55                  60                  


Leu Val Lys Asn Asn Asn Ala Ile Val Arg Asn Asn Glu Ile Ile Val 
65                  70                  75                  80  


Glu Asn Asn Arg Ile Ile Leu Glu Val Leu Glu Leu Leu Leu Arg Ser 
                85                  90                  95      


Ile Lys Gly Ser Gly Gly Ser Gly Asp Arg Glu Glu Ile Lys Lys Val 
            100                 105                 110         


Leu Asp Glu Leu Arg Glu Ser Thr Glu Arg Leu Glu Arg Ser Thr Glu 
        115                 120                 125             


Glu Leu Arg Arg Ser Thr Glu Glu Leu Lys Lys Asn Pro Ala Val Glu 
    130                 135                 140                 


Val Leu Val Arg Asn Asn Thr Ile Ile Val Lys Asn Asn Lys Ile Ile 
145                 150                 155                 160 


Val Asp Asn Asn Arg Ile Ile Val Arg Val Leu Glu Leu Leu Glu Lys 
                165                 170                 175     


Thr Ile Lys Gly Ser Gly Gly Ser Gly Asp Lys Tyr Glu Ile Arg Lys 
            180                 185                 190         


Val Leu Lys Glu Leu Lys Asp Ser Thr Glu Glu Leu Arg Asn Ser Thr 
        195                 200                 205             


Lys Asn Leu Thr Asp Ser Thr Glu Glu Leu Lys Arg Asn Pro Ser Val 
    210                 215                 220                 


Glu Ile Leu Val Lys Asn Asn Ile Leu Ile Val Glu Asn Asn Lys Ile 
225                 230                 235                 240 


Ile Val Glu Asn Asn Arg Ile Ile Val Asp Val Leu Glu Leu Ile Arg 
                245                 250                 255     


Lys Ala Ile Ala Ser 
            260     


<210>  44
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

His Met Gly Ser Asp Asp Glu Asp Ile Asp Arg Val Leu Glu Glu Leu 
1               5                   10                  15      


Arg Arg Ser Thr Glu Glu Leu Asp Arg Ser Thr Lys Asp Leu Glu Arg 
            20                  25                  30          


Ser Thr Gln Glu Leu Arg Arg Asn Pro Ser Val Asp Ala Leu Val Lys 
        35                  40                  45              


Asn Asn Asn Ala Ile Val Arg Asn Asn Glu Ile Ile Val Glu Asn Asn 
    50                  55                  60                  


Arg Ile Ile Leu Glu Val Leu Glu Leu Leu Leu Arg Ser Ile Lys Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Asp Arg Glu Glu Ile Lys Lys Val Leu Asp Glu 
                85                  90                  95      


Leu Arg Glu Ser Thr Glu Arg Leu Glu Arg Ser Thr Glu Glu Leu Arg 
            100                 105                 110         


Arg Ser Thr Glu Glu Leu Lys Lys Asn Pro Ala Val Glu Val Leu Val 
        115                 120                 125             


Arg Asn Asn Thr Ile Ile Val Lys Asn Asn Lys Ile Ile Val Asp Asn 
    130                 135                 140                 


Asn Arg Ile Ile Val Arg Val Leu Glu Leu Leu Glu Lys Thr Ile Lys 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Asp Lys Tyr Glu Ile Arg Lys Val Leu Lys 
                165                 170                 175     


Glu Leu Lys Asp Ser Thr Glu Glu Leu Arg Asn Ser Thr Lys Asn Leu 
            180                 185                 190         


Thr Asp Ser Thr Glu Glu Leu Lys Arg Asn Pro Ser Val Glu Ile Leu 
        195                 200                 205             


Val Lys Asn Asn Ile Leu Ile Val Glu Asn Asn Lys Ile Ile Val Glu 
    210                 215                 220                 


Asn Asn Arg Ile Ile Val Asp Val Leu Glu Leu Ile Arg Lys Ala Ile 
225                 230                 235                 240 


Ala Ser 
        


<210>  45
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Ser Asp Asp Glu Asp Ile Asp Arg Val Leu 
            20                  25                  30          


Glu Glu Leu Arg Arg Ile Thr Glu Glu Leu Asp Arg Ile Thr Lys Asp 
        35                  40                  45              


Leu Glu Arg Leu Thr Gln Glu Leu Arg Arg Asn Pro Ser Val Asp Ala 
    50                  55                  60                  


Leu Val Lys His Asn Asn Ala Ile Val Arg His Asn Glu Ile Ile Val 
65                  70                  75                  80  


Glu His Asn Arg Ile Ile Leu Glu Val Leu Glu Leu Leu Leu Arg Ser 
                85                  90                  95      


Ile Lys Gly Ser Gly Gly Ser Gly Asp Arg Glu Glu Ile Lys Lys Val 
            100                 105                 110         


Leu Asp Glu Leu Arg Glu Ala Thr Glu Arg Leu Glu Arg Ala Thr Glu 
        115                 120                 125             


Glu Leu Arg Arg Leu Thr Glu Glu Leu Lys Lys Asn Pro Ala Val Glu 
    130                 135                 140                 


Val Leu Val Arg His Asn Thr Ile Ile Val Lys His Asn Lys Ile Ile 
145                 150                 155                 160 


Val Asp His Asn Arg Ile Ile Val Arg Val Leu Glu Leu Leu Glu Lys 
                165                 170                 175     


Thr Ile Lys Gly Ser Gly Gly Ser Gly Asp Lys Tyr Glu Ile Arg Lys 
            180                 185                 190         


Val Leu Lys Glu Leu Lys Asp Ile Thr Glu Glu Leu Arg Asn Met Thr 
        195                 200                 205             


Lys Asn Leu Thr Asp Leu Thr Glu Glu Leu Lys Arg Asn Pro Ser Val 
    210                 215                 220                 


Glu Ile Leu Val Lys His Asn Ile Leu Ile Val Glu His Asn Lys Ile 
225                 230                 235                 240 


Ile Val Glu His Asn Arg Ile Ile Val Asp Val Leu Glu Leu Ile Arg 
                245                 250                 255     


Lys Ala Ile Ala Ser 
            260     


<210>  46
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

His Met Gly Ser Asp Asp Glu Asp Ile Asp Arg Val Leu Glu Glu Leu 
1               5                   10                  15      


Arg Arg Ile Thr Glu Glu Leu Asp Arg Ile Thr Lys Asp Leu Glu Arg 
            20                  25                  30          


Leu Thr Gln Glu Leu Arg Arg Asn Pro Ser Val Asp Ala Leu Val Lys 
        35                  40                  45              


His Asn Asn Ala Ile Val Arg His Asn Glu Ile Ile Val Glu His Asn 
    50                  55                  60                  


Arg Ile Ile Leu Glu Val Leu Glu Leu Leu Leu Arg Ser Ile Lys Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Asp Arg Glu Glu Ile Lys Lys Val Leu Asp Glu 
                85                  90                  95      


Leu Arg Glu Ala Thr Glu Arg Leu Glu Arg Ala Thr Glu Glu Leu Arg 
            100                 105                 110         


Arg Leu Thr Glu Glu Leu Lys Lys Asn Pro Ala Val Glu Val Leu Val 
        115                 120                 125             


Arg His Asn Thr Ile Ile Val Lys His Asn Lys Ile Ile Val Asp His 
    130                 135                 140                 


Asn Arg Ile Ile Val Arg Val Leu Glu Leu Leu Glu Lys Thr Ile Lys 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Asp Lys Tyr Glu Ile Arg Lys Val Leu Lys 
                165                 170                 175     


Glu Leu Lys Asp Ile Thr Glu Glu Leu Arg Asn Met Thr Lys Asn Leu 
            180                 185                 190         


Thr Asp Leu Thr Glu Glu Leu Lys Arg Asn Pro Ser Val Glu Ile Leu 
        195                 200                 205             


Val Lys His Asn Ile Leu Ile Val Glu His Asn Lys Ile Ile Val Glu 
    210                 215                 220                 


His Asn Arg Ile Ile Val Asp Val Leu Glu Leu Ile Arg Lys Ala Ile 
225                 230                 235                 240 


Ala Ser 
        


<210>  47
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val 
            20                  25                  30          


Pro Val Leu Ile Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser 
        35                  40                  45              


Val Arg Gly Glu Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile 
    50                  55                  60                  


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
65                  70                  75                  80  


Val Thr Thr Leu Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu 
                85                  90                  95      


His Met Lys Met Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
            100                 105                 110         


Ile Gln Glu Arg Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr 
        115                 120                 125             


Arg Gly Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
    130                 135                 140                 


Leu Lys Gly Lys Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
145                 150                 155                 160 


Leu Glu Tyr Ser Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys 
                165                 170                 175     


Ala Asn Asn Gly Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu 
            180                 185                 190         


Gly Gly Gly Val Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Thr Lys Ile Ser Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Ser Phe Ser Ala Cys Cys His Thr Gly Gly Ser Gly Gly Ser 
                245                 250                 255     


Glu Asn Leu Tyr Phe Gln Gly Ala Ser Gly Gly Ser Gly Ser Glu Leu 
            260                 265                 270         


Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp 
        275                 280                 285             


Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu 
    290                 295                 300                 


Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro 
305                 310                 315                 320 


Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr 
                325                 330                 335     


Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe 
            340                 345                 350         


Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly 
        355                 360                 365             


Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile 
    370                 375                 380                 


Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val 
385                 390                 395                 400 


Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr 
                405                 410                 415     


Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu 
            420                 425                 430         


Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser 
        435                 440                 445             


Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp 
    450                 455                 460                 


Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu 
465                 470                 475                 480 


Gln His Glu Val Ala Val Ala Arg Tyr 
                485                 


<210>  48
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

His Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu 
1               5                   10                  15      


Ile Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys 
65                  70                  75                  80  


Met Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Lys Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Ser Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn 
145                 150                 155                 160 


Gly Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile 
        195                 200                 205             


Ser Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser 
    210                 215                 220                 


Phe Ser Ala Cys Cys His Thr Gly Gly Ser Gly Gly Ser Glu Asn Leu 
225                 230                 235                 240 


Tyr Phe Gln Gly Ala Ser Gly Gly Ser Gly Ser Glu Leu Ile Lys Glu 
                245                 250                 255     


Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His 
            260                 265                 270         


Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln 
        275                 280                 285             


Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe 
    290                 295                 300                 


Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn 
305                 310                 315                 320 


His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly 
                325                 330                 335     


Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr 
            340                 345                 350         


Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val 
        355                 360                 365             


Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys 
    370                 375                 380                 


Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp 
385                 390                 395                 400 


Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly 
                405                 410                 415     


Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro 
            420                 425                 430         


Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu 
        435                 440                 445             


Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu 
    450                 455                 460                 


Val Ala Val Ala Arg Tyr 
465                 470 


<210>  49
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val 
            20                  25                  30          


Pro Val Leu Ile Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser 
        35                  40                  45              


Val Arg Gly Glu Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile 
    50                  55                  60                  


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
65                  70                  75                  80  


Val Thr Thr Leu Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu 
                85                  90                  95      


His Met Lys Met Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
            100                 105                 110         


Ile Gln Glu Arg Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr 
        115                 120                 125             


Arg Gly Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
    130                 135                 140                 


Leu Lys Gly Lys Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
145                 150                 155                 160 


Leu Glu Tyr Ser Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys 
                165                 170                 175     


Ala Asn Asn Gly Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu 
            180                 185                 190         


Gly Gly Gly Val Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Thr Lys Ile Ser Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Ser Phe Ser Ala Cys Cys His Thr Gly Gly Ser Gly Gly Ser 
                245                 250                 255     


Asp Glu Leu Lys Tyr Glu Leu Glu Lys Ser Thr Arg Glu Leu Gln Lys 
            260                 265                 270         


Ser Thr Asp Glu Leu Glu Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro 
        275                 280                 285             


Ser Lys Asp Val Leu Val Glu Asn Asn Glu Leu Ile Val Arg Asn Asn 
    290                 295                 300                 


Lys Ile Ile Val Lys Asn Asn Ile Ile Ile Val Arg Thr Glu Lys Lys 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu Glu Lys Ser 
                325                 330                 335     


Thr Arg Glu Leu Asp Lys Ser Thr Lys Lys Leu Glu Arg Ser Thr Glu 
            340                 345                 350         


Glu Leu Lys Arg Asn Pro Ser Lys Asp Ala Leu Val Glu Asn Asn Lys 
        355                 360                 365             


Leu Ile Val Glu Asn Asn Thr Ile Ile Val Arg Asn Asn Asp Ile Ile 
    370                 375                 380                 


Val Arg Thr Arg Lys Lys Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Lys Ser Thr Arg Glu Leu Lys Lys Ser Thr Lys Glu 
                405                 410                 415     


Leu Gln Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp Ala 
            420                 425                 430         


Leu Val Lys Asn Asn Lys Leu Ile Ala Asp Asn Asn Arg Ile Ile Val 
        435                 440                 445             


Arg Asn Asn Thr Ile Ile Val Arg Asp Ile Lys Ala Ser Gly Gly Ser 
    450                 455                 460                 


Gly Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
465                 470                 475                 480 


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
                485                 490                 495     


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
            500                 505                 510         


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
        515                 520                 525             


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
    530                 535                 540                 


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
545                 550                 555                 560 


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
                565                 570                 575     


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
            580                 585                 590         


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
        595                 600                 605             


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
    610                 615                 620                 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
625                 630                 635                 640 


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
                645                 650                 655     


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
            660                 665                 670         


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr 
        675                 680                 685 


<210>  50
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

His Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu 
1               5                   10                  15      


Ile Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys 
65                  70                  75                  80  


Met Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Lys Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Ser Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn 
145                 150                 155                 160 


Gly Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile 
        195                 200                 205             


Ser Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser 
    210                 215                 220                 


Phe Ser Ala Cys Cys His Thr Gly Gly Ser Gly Gly Ser Asp Glu Leu 
225                 230                 235                 240 


Lys Tyr Glu Leu Glu Lys Ser Thr Arg Glu Leu Gln Lys Ser Thr Asp 
                245                 250                 255     


Glu Leu Glu Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp 
            260                 265                 270         


Val Leu Val Glu Asn Asn Glu Leu Ile Val Arg Asn Asn Lys Ile Ile 
        275                 280                 285             


Val Lys Asn Asn Ile Ile Ile Val Arg Thr Glu Lys Lys Gly Ser Gly 
    290                 295                 300                 


Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu Glu Lys Ser Thr Arg Glu 
305                 310                 315                 320 


Leu Asp Lys Ser Thr Lys Lys Leu Glu Arg Ser Thr Glu Glu Leu Lys 
                325                 330                 335     


Arg Asn Pro Ser Lys Asp Ala Leu Val Glu Asn Asn Lys Leu Ile Val 
            340                 345                 350         


Glu Asn Asn Thr Ile Ile Val Arg Asn Asn Asp Ile Ile Val Arg Thr 
        355                 360                 365             


Arg Lys Lys Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu 
    370                 375                 380                 


Glu Lys Ser Thr Arg Glu Leu Lys Lys Ser Thr Lys Glu Leu Gln Lys 
385                 390                 395                 400 


Ser Thr Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp Ala Leu Val Lys 
                405                 410                 415     


Asn Asn Lys Leu Ile Ala Asp Asn Asn Arg Ile Ile Val Arg Asn Asn 
            420                 425                 430         


Thr Ile Ile Val Arg Asp Ile Lys Ala Ser Gly Gly Ser Gly Ser Glu 
        435                 440                 445             


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
    450                 455                 460                 


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
465                 470                 475                 480 


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
                485                 490                 495     


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
            500                 505                 510         


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
        515                 520                 525             


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
    530                 535                 540                 


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
545                 550                 555                 560 


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
                565                 570                 575     


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
            580                 585                 590         


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
        595                 600                 605             


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
    610                 615                 620                 


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
625                 630                 635                 640 


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
                645                 650                 655     


Glu Gln His Glu Val Ala Val Ala Arg Tyr 
            660                 665     


<210>  51
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val 
            20                  25                  30          


Pro Val Leu Ile Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser 
        35                  40                  45              


Val Arg Gly Glu Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile 
    50                  55                  60                  


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
65                  70                  75                  80  


Val Thr Thr Leu Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu 
                85                  90                  95      


His Met Lys Met Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
            100                 105                 110         


Ile Gln Glu Arg Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr 
        115                 120                 125             


Arg Gly Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
    130                 135                 140                 


Leu Lys Gly Lys Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
145                 150                 155                 160 


Leu Glu Tyr Ser Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys 
                165                 170                 175     


Ala Asn Asn Gly Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu 
            180                 185                 190         


Gly Gly Gly Val Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Thr Lys Ile Ser Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Ser Phe Ser Ala Cys Cys His Thr Gly Gly Ser Gly Gly Ser 
                245                 250                 255     


Asp Glu Leu Lys Tyr Glu Leu Glu Lys Ser Thr Arg Glu Leu Gln Lys 
            260                 265                 270         


Ser Thr Asp Glu Leu Glu Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro 
        275                 280                 285             


Ser Lys Asp Val Leu Val Glu Asn Asn Glu Leu Ile Val Arg Asn Asn 
    290                 295                 300                 


Lys Ile Ile Val Lys Asn Asn Ile Ile Ile Val Arg Thr Glu Lys Lys 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu Glu Lys Ser 
                325                 330                 335     


Thr Arg Glu Leu Asp Lys Ser Thr Lys Lys Leu Glu Arg Ser Thr Glu 
            340                 345                 350         


Glu Leu Lys Arg Asn Pro Ser Lys Asp Ala Leu Val Glu Asn Asn Lys 
        355                 360                 365             


Leu Ile Val Glu Asn Asn Thr Ile Ile Val Arg Asn Asn Asp Ile Ile 
    370                 375                 380                 


Val Arg Thr Arg Lys Lys Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Lys Ser Thr Arg Glu Leu Lys Lys Ser Thr Lys Glu 
                405                 410                 415     


Leu Gln Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp Ala 
            420                 425                 430         


Leu Val Lys Asn Asn Lys Leu Ile Ala Asp Asn Asn Arg Ile Ile Val 
        435                 440                 445             


Arg Asn Asn Thr Ile Ile Val Arg Asp Ile Lys Ala Ser Gly Gly Ser 
    450                 455                 460                 


Gly Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
465                 470                 475                 480 


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
                485                 490                 495     


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
            500                 505                 510         


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
        515                 520                 525             


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
    530                 535                 540                 


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
545                 550                 555                 560 


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
                565                 570                 575     


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
            580                 585                 590         


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
        595                 600                 605             


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
    610                 615                 620                 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
625                 630                 635                 640 


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
                645                 650                 655     


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
            660                 665                 670         


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr 
        675                 680                 685 


<210>  52
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

His Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu 
1               5                   10                  15      


Ile Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys 
65                  70                  75                  80  


Met Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Lys Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Ser Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn 
145                 150                 155                 160 


Gly Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile 
        195                 200                 205             


Ser Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser 
    210                 215                 220                 


Phe Ser Ala Cys Cys His Thr Gly Gly Ser Gly Gly Ser Asp Glu Leu 
225                 230                 235                 240 


Lys Tyr Glu Leu Glu Lys Ser Thr Arg Glu Leu Gln Lys Ser Thr Asp 
                245                 250                 255     


Glu Leu Glu Lys Ser Thr Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp 
            260                 265                 270         


Val Leu Val Glu Asn Asn Glu Leu Ile Val Arg Asn Asn Lys Ile Ile 
        275                 280                 285             


Val Lys Asn Asn Ile Ile Ile Val Arg Thr Glu Lys Lys Gly Ser Gly 
    290                 295                 300                 


Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu Glu Lys Ser Thr Arg Glu 
305                 310                 315                 320 


Leu Asp Lys Ser Thr Lys Lys Leu Glu Arg Ser Thr Glu Glu Leu Lys 
                325                 330                 335     


Arg Asn Pro Ser Lys Asp Ala Leu Val Glu Asn Asn Lys Leu Ile Val 
            340                 345                 350         


Glu Asn Asn Thr Ile Ile Val Arg Asn Asn Asp Ile Ile Val Arg Thr 
        355                 360                 365             


Arg Lys Lys Gly Ser Gly Gly Ser Gly Asp Glu Leu Lys Glu Glu Leu 
    370                 375                 380                 


Glu Lys Ser Thr Arg Glu Leu Lys Lys Ser Thr Lys Glu Leu Gln Lys 
385                 390                 395                 400 


Ser Thr Glu Glu Leu Glu Arg Asn Pro Ser Lys Asp Ala Leu Val Lys 
                405                 410                 415     


Asn Asn Lys Leu Ile Ala Asp Asn Asn Arg Ile Ile Val Arg Asn Asn 
            420                 425                 430         


Thr Ile Ile Val Arg Asp Ile Lys Ala Ser Gly Gly Ser Gly Ser Glu 
        435                 440                 445             


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
    450                 455                 460                 


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
465                 470                 475                 480 


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
                485                 490                 495     


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
            500                 505                 510         


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
        515                 520                 525             


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
    530                 535                 540                 


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
545                 550                 555                 560 


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
                565                 570                 575     


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
            580                 585                 590         


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
        595                 600                 605             


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
    610                 615                 620                 


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
625                 630                 635                 640 


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
                645                 650                 655     


Glu Gln His Glu Val Ala Val Ala Arg Tyr 
            660                 665     


<210>  53
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Gly Ile His Gly Asn Val Tyr Ile 
            20                  25                  30          


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn 
        35                  40                  45              


Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
    50                  55                  60                  


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
65                  70                  75                  80  


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                85                  90                  95      


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            100                 105                 110         


Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys 
        115                 120                 125             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    130                 135                 140                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
145                 150                 155                 160 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                165                 170                 175     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly 
            180                 185                 190         


Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
        195                 200                 205             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
    210                 215                 220                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
225                 230                 235                 240 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                245                 250                 255     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265             


<210>  54
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Phe Gln Gly Ser Gly Ser Gly Gly Ile His Gly Asn Val Tyr Ile Thr 
1               5                   10                  15      


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser 
            20                  25                  30          


Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        35                  40                  45              


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
    50                  55                  60                  


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
65                  70                  75                  80  


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
                85                  90                  95      


Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly 
            100                 105                 110         


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
        115                 120                 125             


Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp 
    130                 135                 140                 


Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys 
145                 150                 155                 160 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val 
                165                 170                 175     


Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
            180                 185                 190         


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
        195                 200                 205             


Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
    210                 215                 220                 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
225                 230                 235                 240 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
                245                 250     


<210>  55
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg 
            20                  25                  30          


Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu 
        35                  40                  45              


Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu 
    50                  55                  60                  


Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile 
65                  70                  75                  80  


Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala 
                85                  90                  95      


Lys Ser Asp Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg 
            100                 105                 110         


Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu 
        115                 120                 125             


Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu 
    130                 135                 140                 


Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala 
                165                 170                 175     


Lys Ser Asp Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp 
            180                 185                 190         


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val 
        195                 200                 205             


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
    210                 215                 220                 


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
                245                 250                 255     


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
            260                 265                 270         


Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu 
        275                 280                 285             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    290                 295                 300                 


Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr 
305                 310                 315                 320 


Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro 
                325                 330                 335     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser 
            340                 345                 350         


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        355                 360                 365             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    370                 375                 380                 


Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
385                 390                 395                 400 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                405                 410                 415     


Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Gly Ser Thr Lys Tyr Glu 
            420                 425                 430         


Leu Arg Arg Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys 
        435                 440                 445             


Lys Ser Leu Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn 
    450                 455                 460                 


Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn 
465                 470                 475                 480 


Asn Lys Ile Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys 
                485                 490                 495     


Ile Asn Ala Lys Ser Asp 
            500         


<210>  56
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Phe Gln Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg Ala 
1               5                   10                  15      


Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu Asp 
            20                  25                  30          


Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp 
        35                  40                  45              


Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile Ile 
    50                  55                  60                  


Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala Lys 
65                  70                  75                  80  


Ser Asp Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg Ala 
                85                  90                  95      


Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu Asp 
            100                 105                 110         


Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp 
        115                 120                 125             


Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile Ile 
    130                 135                 140                 


Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala Lys 
145                 150                 155                 160 


Ser Asp Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp Lys 
                165                 170                 175     


Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val Glu 
            180                 185                 190         


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
                245                 250                 255     


Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            260                 265                 270         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        275                 280                 285             


Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn 
    290                 295                 300                 


Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val 
305                 310                 315                 320 


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser Phe 
                325                 330                 335     


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            340                 345                 350         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        355                 360                 365             


Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    370                 375                 380                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
385                 390                 395                 400 


Ile Leu Gly His Lys Leu Glu Tyr Gly Gly Ser Thr Lys Tyr Glu Leu 
                405                 410                 415     


Arg Arg Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys 
            420                 425                 430         


Ser Leu Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro 
        435                 440                 445             


Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn 
    450                 455                 460                 


Lys Ile Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile 
465                 470                 475                 480 


Asn Ala Lys Ser Asp 
                485 


<210>  57
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Phe Gln Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg Ala 
1               5                   10                  15      


Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu Asp 
            20                  25                  30          


Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp 
        35                  40                  45              


Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile Ile 
    50                  55                  60                  


Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala Lys 
65                  70                  75                  80  


Ser Asp Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg Ala 
                85                  90                  95      


Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu Asp 
            100                 105                 110         


Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp 
        115                 120                 125             


Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile Ile 
    130                 135                 140                 


Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala Lys 
145                 150                 155                 160 


Ser Asp Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp Lys 
                165                 170                 175     


Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val Glu 
            180                 185                 190         


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
                245                 250                 255     


Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            260                 265                 270         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        275                 280                 285             


Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn 
    290                 295                 300                 


Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val 
305                 310                 315                 320 


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser Phe 
                325                 330                 335     


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            340                 345                 350         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        355                 360                 365             


Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    370                 375                 380                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
385                 390                 395                 400 


Ile Leu Gly His Lys Leu Glu Tyr Gly Gly Ser Thr Lys Tyr Glu Leu 
                405                 410                 415     


Arg Arg Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys 
            420                 425                 430         


Ser Leu Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro 
        435                 440                 445             


Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn 
    450                 455                 460                 


Lys Ile Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile 
465                 470                 475                 480 


Asn Ala Lys Ser Asp Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
                485                 490                 495     


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
            500                 505                 510         


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
        515                 520                 525             


Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
    530                 535                 540                 


Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Met Phe Ala Arg Tyr 
545                 550                 555                 560 


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
                565                 570                 575     


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
            580                 585                 590         


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
        595                 600                 605             


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
    610                 615                 620                 


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala 
625                 630                 635                 640 


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
                645                 650                 655     


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
            660                 665                 670         


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
        675                 680                 685             


Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
    690                 695                 700                 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
705                 710                 715                 720 


Glu Leu Tyr Lys 
                


<210>  58
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg 
            20                  25                  30          


Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu 
        35                  40                  45              


Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu 
    50                  55                  60                  


Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile 
65                  70                  75                  80  


Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala 
                85                  90                  95      


Lys Ser Asp Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg 
            100                 105                 110         


Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu 
        115                 120                 125             


Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu 
    130                 135                 140                 


Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala 
                165                 170                 175     


Lys Ser Asp Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp 
            180                 185                 190         


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val 
        195                 200                 205             


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
    210                 215                 220                 


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
                245                 250                 255     


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
            260                 265                 270         


Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu 
        275                 280                 285             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    290                 295                 300                 


Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr 
305                 310                 315                 320 


Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro 
                325                 330                 335     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser 
            340                 345                 350         


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        355                 360                 365             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    370                 375                 380                 


Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
385                 390                 395                 400 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                405                 410                 415     


Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser Thr Lys Tyr 
            420                 425                 430         


Glu Leu Arg Arg Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu 
        435                 440                 445             


Lys Lys Ser Leu Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys 
    450                 455                 460                 


Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu 
465                 470                 475                 480 


Asn Asn Lys Ile Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu 
                485                 490                 495     


Lys Ile Asn Ala Lys Ser Asp Met Val Ser Lys Gly Glu Glu Leu Phe 
            500                 505                 510         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        515                 520                 525             


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    530                 535                 540                 


Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro 
545                 550                 555                 560 


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Met Phe Ala 
                565                 570                 575     


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            580                 585                 590         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        595                 600                 605             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    610                 615                 620                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
625                 630                 635                 640 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                645                 650                 655     


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
            660                 665                 670         


His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln 
        675                 680                 685             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    690                 695                 700                 


Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
705                 710                 715                 720 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                725                 730                 735     


Met Asp Glu Leu Tyr Lys 
            740         


<210>  59
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Phe Gln Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg Ala 
1               5                   10                  15      


Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu Asp 
            20                  25                  30          


Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp 
        35                  40                  45              


Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile Ile 
    50                  55                  60                  


Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala Lys 
65                  70                  75                  80  


Ser Asp Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg Ala 
                85                  90                  95      


Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu Asp 
            100                 105                 110         


Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp 
        115                 120                 125             


Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile Ile 
    130                 135                 140                 


Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala Lys 
145                 150                 155                 160 


Ser Asp Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp Lys 
                165                 170                 175     


Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val Glu 
            180                 185                 190         


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
                245                 250                 255     


Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            260                 265                 270         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        275                 280                 285             


Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn 
    290                 295                 300                 


Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val 
305                 310                 315                 320 


Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser Phe 
                325                 330                 335     


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            340                 345                 350         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        355                 360                 365             


Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    370                 375                 380                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
385                 390                 395                 400 


Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser Thr Lys Tyr Glu 
                405                 410                 415     


Leu Arg Arg Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys 
            420                 425                 430         


Lys Ser Leu Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn 
        435                 440                 445             


Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn 
    450                 455                 460                 


Asn Lys Ile Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys 
465                 470                 475                 480 


Ile Asn Ala Lys Ser Asp Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
                485                 490                 495     


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
            500                 505                 510         


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
        515                 520                 525             


Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp 
    530                 535                 540                 


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Met Phe Ala Arg 
545                 550                 555                 560 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
                565                 570                 575     


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
            580                 585                 590         


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
        595                 600                 605             


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
    610                 615                 620                 


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr 
625                 630                 635                 640 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
                645                 650                 655     


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
            660                 665                 670         


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
        675                 680                 685             


Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
    690                 695                 700                 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
705                 710                 715                 720 


Asp Glu Leu Tyr Lys 
                725 


<210>  60
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu 
            20                  25                  30          


Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala 
        35                  40                  45              


Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His 
    50                  55                  60                  


Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg 
65                  70                  75                  80  


Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu 
                85                  90                  95      


Tyr Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu 
            100                 105                 110         


Leu Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala 
        115                 120                 125             


Leu Val Glu His Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala 
    130                 135                 140                 


Glu His Asn Arg Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His 
145                 150                 155                 160 


Gly Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                165                 170                 175     


Asn Phe Gly Leu Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
            180                 185                 190         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        195                 200                 205             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
    210                 215                 220                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
225                 230                 235                 240 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly 
                245                 250                 255     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            260                 265                 270         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg 
        275                 280                 285             


Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe 
    290                 295                 300                 


Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
305                 310                 315                 320 


Thr Leu Ser Trp Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met 
                325                 330                 335     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            340                 345                 350         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
        355                 360                 365             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    370                 375                 380                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
385                 390                 395                 400 


Tyr Gly Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg Glu 
                405                 410                 415     


Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu Glu 
            420                 425                 430         


Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala 
        435                 440                 445             


Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys Val 
    450                 455                 460                 


Leu Lys 
465     


<210>  61
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Phe Gln Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys 
1               5                   10                  15      


Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr 
            20                  25                  30          


Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn 
        35                  40                  45              


Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile 
    50                  55                  60                  


Ile Ala Lys Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr 
65                  70                  75                  80  


Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu 
                85                  90                  95      


Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu 
            100                 105                 110         


Val Glu His Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu 
        115                 120                 125             


His Asn Arg Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His Gly 
    130                 135                 140                 


Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
145                 150                 155                 160 


Phe Gly Leu Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp 
                165                 170                 175     


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
            180                 185                 190         


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
        195                 200                 205             


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
    210                 215                 220                 


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
225                 230                 235                 240 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                245                 250                 255     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            260                 265                 270         


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        275                 280                 285             


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    290                 295                 300                 


Leu Ser Trp Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys 
305                 310                 315                 320 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                325                 330                 335     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
            340                 345                 350         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        355                 360                 365             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    370                 375                 380                 


Gly Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg Glu Leu 
385                 390                 395                 400 


Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu Glu Lys 
                405                 410                 415     


Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala Glu 
            420                 425                 430         


His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys Val Leu 
        435                 440                 445             


Lys 
    


<210>  62
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu 
            20                  25                  30          


Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala 
        35                  40                  45              


Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His 
    50                  55                  60                  


Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg 
65                  70                  75                  80  


Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu 
                85                  90                  95      


Tyr Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu 
            100                 105                 110         


Leu Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala 
        115                 120                 125             


Leu Val Glu His Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala 
    130                 135                 140                 


Glu His Asn Arg Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His 
145                 150                 155                 160 


Gly Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                165                 170                 175     


Asn Phe Gly Leu Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
            180                 185                 190         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        195                 200                 205             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
    210                 215                 220                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
225                 230                 235                 240 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly 
                245                 250                 255     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            260                 265                 270         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg 
        275                 280                 285             


Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe 
    290                 295                 300                 


Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
305                 310                 315                 320 


Thr Leu Ser Trp Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met 
                325                 330                 335     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            340                 345                 350         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
        355                 360                 365             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    370                 375                 380                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
385                 390                 395                 400 


Tyr Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg 
                405                 410                 415     


Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu 
            420                 425                 430         


Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile 
        435                 440                 445             


Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys 
    450                 455                 460                 


Val Leu Lys 
465         


<210>  63
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Phe Gln Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys 
1               5                   10                  15      


Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr 
            20                  25                  30          


Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn 
        35                  40                  45              


Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile 
    50                  55                  60                  


Ile Ala Lys Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr 
65                  70                  75                  80  


Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu 
                85                  90                  95      


Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu 
            100                 105                 110         


Val Glu His Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu 
        115                 120                 125             


His Asn Arg Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His Gly 
    130                 135                 140                 


Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
145                 150                 155                 160 


Phe Gly Leu Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp 
                165                 170                 175     


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
            180                 185                 190         


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
        195                 200                 205             


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
    210                 215                 220                 


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
225                 230                 235                 240 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                245                 250                 255     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            260                 265                 270         


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        275                 280                 285             


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    290                 295                 300                 


Leu Ser Trp Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys 
305                 310                 315                 320 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                325                 330                 335     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
            340                 345                 350         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        355                 360                 365             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    370                 375                 380                 


Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg Glu 
385                 390                 395                 400 


Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu Glu 
                405                 410                 415     


Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala 
            420                 425                 430         


Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys Val 
        435                 440                 445             


Leu Lys 
    450 


<210>  64
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu 
            20                  25                  30          


Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala 
        35                  40                  45              


Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His 
    50                  55                  60                  


Asn Arg Leu Ile Ala Glu His Asn Lys Ile Val Ala Glu His Asn Arg 
65                  70                  75                  80  


Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu 
                85                  90                  95      


Tyr Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu 
            100                 105                 110         


Leu Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala 
        115                 120                 125             


Leu Val Glu His Asn Arg Leu Ile Ala Glu His Asn Lys Ile Val Ala 
    130                 135                 140                 


Glu His Asn Arg Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His 
145                 150                 155                 160 


Gly Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                165                 170                 175     


Asn Phe Gly Leu Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
            180                 185                 190         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        195                 200                 205             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
    210                 215                 220                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
225                 230                 235                 240 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly 
                245                 250                 255     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            260                 265                 270         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg 
        275                 280                 285             


Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe 
    290                 295                 300                 


Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
305                 310                 315                 320 


Thr Leu Ser Trp Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met 
                325                 330                 335     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            340                 345                 350         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
        355                 360                 365             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    370                 375                 380                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
385                 390                 395                 400 


Tyr Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg 
                405                 410                 415     


Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu 
            420                 425                 430         


Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile 
        435                 440                 445             


Ala Glu His Asn Lys Ile Val Ala Glu His Asn Arg Ile Ile Ala Lys 
    450                 455                 460                 


Val Leu Lys 
465         


<210>  65
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Phe Gln Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys 
1               5                   10                  15      


Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr 
            20                  25                  30          


Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn 
        35                  40                  45              


Arg Leu Ile Ala Glu His Asn Lys Ile Val Ala Glu His Asn Arg Ile 
    50                  55                  60                  


Ile Ala Lys Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr 
65                  70                  75                  80  


Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu 
                85                  90                  95      


Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu 
            100                 105                 110         


Val Glu His Asn Arg Leu Ile Ala Glu His Asn Lys Ile Val Ala Glu 
        115                 120                 125             


His Asn Arg Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His Gly 
    130                 135                 140                 


Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
145                 150                 155                 160 


Phe Gly Leu Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp 
                165                 170                 175     


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
            180                 185                 190         


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
        195                 200                 205             


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
    210                 215                 220                 


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
225                 230                 235                 240 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                245                 250                 255     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            260                 265                 270         


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        275                 280                 285             


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    290                 295                 300                 


Leu Ser Trp Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys 
305                 310                 315                 320 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                325                 330                 335     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
            340                 345                 350         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        355                 360                 365             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    370                 375                 380                 


Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg Glu 
385                 390                 395                 400 


Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu Glu 
                405                 410                 415     


Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala 
            420                 425                 430         


Glu His Asn Lys Ile Val Ala Glu His Asn Arg Ile Ile Ala Lys Val 
        435                 440                 445             


Leu Lys 
    450 


<210>  66
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg 
1               5                   10                  15      


Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu 
            20                  25                  30          


Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile 
        35                  40                  45              


Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys 
    50                  55                  60                  


Val Leu Lys Gly Ser Gly Ser Gly Ser Glu Ala Leu Tyr Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Thr Arg Glu Leu Lys Lys Ala Thr Asp Glu Leu Glu Arg Ala 
                85                  90                  95      


Thr Glu Glu Leu Glu Lys Asn Pro Ser Glu Asp Ala Leu Val Glu His 
            100                 105                 110         


Asn Arg Leu Ile Ala Glu His Asn Lys Ile Ile Ala Glu His Asn Arg 
        115                 120                 125             


Ile Ile Ala Lys Val Leu Lys Gly Ser Gly Ile His Gly Asn Val Tyr 
    130                 135                 140                 


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu 
145                 150                 155                 160 


Asn Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
                165                 170                 175     


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
            180                 185                 190         


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
        195                 200                 205             


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
    210                 215                 220                 


Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser 
225                 230                 235                 240 


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
                245                 250                 255     


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu 
            260                 265                 270         


Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr 
        275                 280                 285             


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp 
    290                 295                 300                 


Gly Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
305                 310                 315                 320 


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
                325                 330                 335     


Phe Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe 
            340                 345                 350         


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
        355                 360                 365             


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly 
    370                 375                 380                 


Ser Glu Ala Leu Tyr Glu Leu Glu Lys Ala Thr Arg Glu Leu Lys Lys 
385                 390                 395                 400 


Ala Thr Asp Glu Leu Glu Arg Ala Thr Glu Glu Leu Glu Lys Asn Pro 
                405                 410                 415     


Ser Glu Asp Ala Leu Val Glu His Asn Arg Leu Ile Ala Glu His Asn 
            420                 425                 430         


Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys Val Leu Lys Met 
        435                 440                 445             


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
    450                 455                 460                 


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
465                 470                 475                 480 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Ser 
                485                 490                 495     


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
            500                 505                 510         


Thr Tyr Gly Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
        515                 520                 525             


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
    530                 535                 540                 


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
545                 550                 555                 560 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
                565                 570                 575     


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
            580                 585                 590         


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
        595                 600                 605             


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
    610                 615                 620                 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
625                 630                 635                 640 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser 
                645                 650                 655     


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
            660                 665                 670         


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
        675                 680                 685     


<210>  67
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr 
            20                  25                  30          


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser 
        35                  40                  45              


Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    50                  55                  60                  


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
65                  70                  75                  80  


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                85                  90                  95      


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
            100                 105                 110         


Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly 
        115                 120                 125             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    130                 135                 140                 


Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp 
145                 150                 155                 160 


Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys 
                165                 170                 175     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val 
            180                 185                 190         


Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        195                 200                 205             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
    210                 215                 220                 


Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
225                 230                 235                 240 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                245                 250                 255     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser Gly 
            260                 265                 270         


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
        275                 280                 285             


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
    290                 295                 300                 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
305                 310                 315                 320 


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
                325                 330                 335     


Leu Thr Tyr Gly Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys 
            340                 345                 350         


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
        355                 360                 365             


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
    370                 375                 380                 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
385                 390                 395                 400 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
                405                 410                 415     


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
            420                 425                 430         


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
        435                 440                 445             


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
    450                 455                 460                 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
465                 470                 475                 480 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
                485                 490                 495     


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            500                 505                 510     


<210>  68
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Phe Gln Gly Ser Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala 
1               5                   10                  15      


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn 
            20                  25                  30          


Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        35                  40                  45              


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
    50                  55                  60                  


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
65                  70                  75                  80  


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
                85                  90                  95      


Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu 
            100                 105                 110         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        115                 120                 125             


Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala 
    130                 135                 140                 


Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu 
145                 150                 155                 160 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln 
                165                 170                 175     


Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            180                 185                 190         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        195                 200                 205             


Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    210                 215                 220                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
225                 230                 235                 240 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser Gly Met 
                245                 250                 255     


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
            260                 265                 270         


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
        275                 280                 285             


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Ser 
    290                 295                 300                 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
305                 310                 315                 320 


Thr Tyr Gly Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
                325                 330                 335     


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
            340                 345                 350         


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
        355                 360                 365             


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
    370                 375                 380                 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
385                 390                 395                 400 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
                405                 410                 415     


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
            420                 425                 430         


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
        435                 440                 445             


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser 
    450                 455                 460                 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
465                 470                 475                 480 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                485                 490                 


<210>  69
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Asp Asp Glu Asp Ile Asp Arg Val 
            20                  25                  30          


Leu Glu Glu Leu Arg Arg Ile Thr Glu Glu Leu Asp Arg Ile Thr Lys 
        35                  40                  45              


Asp Leu Glu Arg Leu Thr Gln Glu Leu Arg Arg Asn Pro Ser Val Asp 
    50                  55                  60                  


Ala Leu Val Lys His Asn Asn Ala Ile Val Arg His Asn Glu Ile Ile 
65                  70                  75                  80  


Val Glu His Asn Arg Ile Ile Leu Glu Val Leu Glu Leu Leu Leu Arg 
                85                  90                  95      


Ser Ile Gly Ser Gly Ser Gly Asp Arg Glu Glu Ile Lys Lys Val Leu 
            100                 105                 110         


Asp Glu Leu Arg Glu Ala Thr Glu Arg Leu Glu Arg Ala Thr Glu Glu 
        115                 120                 125             


Leu Arg Arg Leu Thr Glu Glu Leu Lys Lys Asn Pro Ala Val Glu Val 
    130                 135                 140                 


Leu Val Arg His Asn Thr Ile Ile Val Lys His Asn Lys Ile Ile Val 
145                 150                 155                 160 


Asp His Asn Arg Ile Ile Val Arg Val Leu Glu Leu Leu Glu Lys Thr 
                165                 170                 175     


Ile Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp Lys Gln 
            180                 185                 190         


Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val Glu Asp 
        195                 200                 205             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    210                 215                 220                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
225                 230                 235                 240 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                245                 250                 255     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            260                 265                 270         


Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
        275                 280                 285             


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
    290                 295                 300                 


His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly 
305                 310                 315                 320 


Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro 
                325                 330                 335     


Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser Phe Ala 
            340                 345                 350         


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
        355                 360                 365             


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
    370                 375                 380                 


Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
385                 390                 395                 400 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
                405                 410                 415     


Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Asp Lys Tyr Glu Ile Arg 
            420                 425                 430         


Lys Val Leu Lys Glu Leu Lys Asp Ile Thr Glu Glu Leu Arg Asn Met 
        435                 440                 445             


Thr Lys Asn Leu Thr Asp Leu Thr Glu Glu Leu Lys Arg Asn Pro Ser 
    450                 455                 460                 


Val Glu Ile Leu Val Lys His Asn Ile Leu Ile Val Glu His Asn Lys 
465                 470                 475                 480 


Ile Ile Val Glu His Asn Arg Ile Ile Val Asp Val Leu Glu Leu Ile 
                485                 490                 495     


Arg Lys Ala Ile Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            500                 505                 510         


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        515                 520                 525             


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    530                 535                 540                 


Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
545                 550                 555                 560 


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Met Phe Ala Arg Tyr Pro 
                565                 570                 575     


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            580                 585                 590         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        595                 600                 605             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    610                 615                 620                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
625                 630                 635                 640 


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
                645                 650                 655     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile 
            660                 665                 670         


Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        675                 680                 685             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    690                 695                 700                 


Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
705                 710                 715                 720 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                725                 730                 735     


Leu Tyr Lys 
            


<210>  70
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Phe Gln Gly Ser Gly Ser Gly Asp Asp Glu Asp Ile Asp Arg Val Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Ile Thr Glu Glu Leu Asp Arg Ile Thr Lys Asp 
            20                  25                  30          


Leu Glu Arg Leu Thr Gln Glu Leu Arg Arg Asn Pro Ser Val Asp Ala 
        35                  40                  45              


Leu Val Lys His Asn Asn Ala Ile Val Arg His Asn Glu Ile Ile Val 
    50                  55                  60                  


Glu His Asn Arg Ile Ile Leu Glu Val Leu Glu Leu Leu Leu Arg Ser 
65                  70                  75                  80  


Ile Gly Ser Gly Ser Gly Asp Arg Glu Glu Ile Lys Lys Val Leu Asp 
                85                  90                  95      


Glu Leu Arg Glu Ala Thr Glu Arg Leu Glu Arg Ala Thr Glu Glu Leu 
            100                 105                 110         


Arg Arg Leu Thr Glu Glu Leu Lys Lys Asn Pro Ala Val Glu Val Leu 
        115                 120                 125             


Val Arg His Asn Thr Ile Ile Val Lys His Asn Lys Ile Ile Val Asp 
    130                 135                 140                 


His Asn Arg Ile Ile Val Arg Val Leu Glu Leu Leu Glu Lys Thr Ile 
145                 150                 155                 160 


Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
                165                 170                 175     


Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val Glu Asp Gly 
            180                 185                 190         


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        195                 200                 205             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
    210                 215                 220                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
225                 230                 235                 240 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                245                 250                 255     


Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
            260                 265                 270         


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
        275                 280                 285             


Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys 
    290                 295                 300                 


Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp 
305                 310                 315                 320 


Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser Phe Ala Arg 
                325                 330                 335     


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
            340                 345                 350         


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Thr 
        355                 360                 365             


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
    370                 375                 380                 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
385                 390                 395                 400 


Gly His Lys Leu Glu Tyr Gly Ser Gly Asp Lys Tyr Glu Ile Arg Lys 
                405                 410                 415     


Val Leu Lys Glu Leu Lys Asp Ile Thr Glu Glu Leu Arg Asn Met Thr 
            420                 425                 430         


Lys Asn Leu Thr Asp Leu Thr Glu Glu Leu Lys Arg Asn Pro Ser Val 
        435                 440                 445             


Glu Ile Leu Val Lys His Asn Ile Leu Ile Val Glu His Asn Lys Ile 
    450                 455                 460                 


Ile Val Glu His Asn Arg Ile Ile Val Asp Val Leu Glu Leu Ile Arg 
465                 470                 475                 480 


Lys Ala Ile Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
                485                 490                 495     


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
            500                 505                 510         


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
        515                 520                 525             


Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
    530                 535                 540                 


Val Thr Thr Leu Thr Tyr Gly Val Gln Met Phe Ala Arg Tyr Pro Asp 
545                 550                 555                 560 


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
                565                 570                 575     


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
            580                 585                 590         


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
        595                 600                 605             


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
    610                 615                 620                 


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
625                 630                 635                 640 


Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu 
                645                 650                 655     


Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
            660                 665                 670         


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
        675                 680                 685             


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
    690                 695                 700                 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
705                 710                 715                 720 


Tyr Lys 
        


<210>  71
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Asp Lys Glu Tyr Lys Leu Asp 
            20                  25                  30          


Arg Ile Leu Arg Arg Leu Asp Glu Leu Ile Lys Gln Leu Ser Arg Ile 
        35                  40                  45              


Leu Glu Glu Ile Glu Arg Leu Val Asp Glu Leu Glu Arg Glu Pro Leu 
    50                  55                  60                  


Asp Asp Lys Glu Val Gln Asp Val Ile Glu Arg Ile Val Glu Leu Ile 
65                  70                  75                  80  


Asp Glu His Leu Glu Leu Leu Lys Glu Tyr Ile Lys Leu Leu Glu Glu 
                85                  90                  95      


Tyr Ile Lys Thr Thr Lys Gly Ser Gly Ile His Gly Asn Val Tyr Ile 
            100                 105                 110         


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn 
        115                 120                 125             


Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
    130                 135                 140                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
145                 150                 155                 160 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                165                 170                 175     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            180                 185                 190         


Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys 
        195                 200                 205             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    210                 215                 220                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
225                 230                 235                 240 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                245                 250                 255     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly 
            260                 265                 270         


Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
        275                 280                 285             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
    290                 295                 300                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
305                 310                 315                 320 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                325                 330                 335     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser 
            340                 345                 350         


Pro Ser Lys Glu Tyr Gln Glu Lys Ser Ala Glu Arg Gln Lys Glu Leu 
        355                 360                 365             


Leu His Glu Tyr Glu Lys Leu Val Arg His Leu Arg Glu Leu Val Glu 
    370                 375                 380                 


Lys Leu Gln Arg Arg Glu Leu Asp Lys Glu Glu Val Leu Arg Arg Leu 
385                 390                 395                 400 


Val Glu Ile Leu Glu Arg Leu Lys Asp Leu His Lys Lys Ile Glu Asp 
                405                 410                 415     


Ala His Arg Lys Asn Glu Glu Ala His Lys Glu Asn Lys Met Val Ser 
            420                 425                 430         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        435                 440                 445             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    450                 455                 460                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr 
465                 470                 475                 480 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
                485                 490                 495     


Gly Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
            500                 505                 510         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        515                 520                 525             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    530                 535                 540                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
545                 550                 555                 560 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                565                 570                 575     


Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            580                 585                 590         


Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu 
        595                 600                 605             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    610                 615                 620                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp 
625                 630                 635                 640 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                645                 650                 655     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            660                 665             


<210>  72
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Phe Gln Gly Ser Gly Ser Gly Ser Asp Lys Glu Tyr Lys Leu Asp Arg 
1               5                   10                  15      


Ile Leu Arg Arg Leu Asp Glu Leu Ile Lys Gln Leu Ser Arg Ile Leu 
            20                  25                  30          


Glu Glu Ile Glu Arg Leu Val Asp Glu Leu Glu Arg Glu Pro Leu Asp 
        35                  40                  45              


Asp Lys Glu Val Gln Asp Val Ile Glu Arg Ile Val Glu Leu Ile Asp 
    50                  55                  60                  


Glu His Leu Glu Leu Leu Lys Glu Tyr Ile Lys Leu Leu Glu Glu Tyr 
65                  70                  75                  80  


Ile Lys Thr Thr Lys Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr 
                85                  90                  95      


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser 
            100                 105                 110         


Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        115                 120                 125             


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
    130                 135                 140                 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
145                 150                 155                 160 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
                165                 170                 175     


Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly 
            180                 185                 190         


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
        195                 200                 205             


Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp 
    210                 215                 220                 


Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val 
                245                 250                 255     


Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
            260                 265                 270         


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
        275                 280                 285             


Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
    290                 295                 300                 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
305                 310                 315                 320 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser Pro 
                325                 330                 335     


Ser Lys Glu Tyr Gln Glu Lys Ser Ala Glu Arg Gln Lys Glu Leu Leu 
            340                 345                 350         


His Glu Tyr Glu Lys Leu Val Arg His Leu Arg Glu Leu Val Glu Lys 
        355                 360                 365             


Leu Gln Arg Arg Glu Leu Asp Lys Glu Glu Val Leu Arg Arg Leu Val 
    370                 375                 380                 


Glu Ile Leu Glu Arg Leu Lys Asp Leu His Lys Lys Ile Glu Asp Ala 
385                 390                 395                 400 


His Arg Lys Asn Glu Glu Ala His Lys Glu Asn Lys Met Val Ser Lys 
                405                 410                 415     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            420                 425                 430         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        435                 440                 445             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
    450                 455                 460                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
465                 470                 475                 480 


Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                485                 490                 495     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            500                 505                 510         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        515                 520                 525             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    530                 535                 540                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
545                 550                 555                 560 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                565                 570                 575     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala 
            580                 585                 590         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        595                 600                 605             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
    610                 615                 620                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
625                 630                 635                 640 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                645                 650     


<210>  73
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Pro Ser Lys Glu Tyr Gln Glu 
            20                  25                  30          


Lys Ser Ala Glu Arg Gln Lys Glu Leu Leu His Glu Tyr Glu Lys Leu 
        35                  40                  45              


Val Arg His Leu Arg Glu Leu Val Glu Lys Leu Gln Arg Arg Glu Leu 
    50                  55                  60                  


Asp Lys Glu Glu Val Leu Arg Arg Leu Val Glu Ile Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Asp Leu His Lys Lys Ile Glu Asp Ala His Arg Lys Asn Glu Glu 
                85                  90                  95      


Ala His Lys Glu Asn Lys Gly Ser Gly Ile His Gly Asn Val Tyr Ile 
            100                 105                 110         


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn 
        115                 120                 125             


Ser Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
    130                 135                 140                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
145                 150                 155                 160 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                165                 170                 175     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            180                 185                 190         


Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys 
        195                 200                 205             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    210                 215                 220                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
225                 230                 235                 240 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                245                 250                 255     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly 
            260                 265                 270         


Val Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
        275                 280                 285             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
    290                 295                 300                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
305                 310                 315                 320 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                325                 330                 335     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser 
            340                 345                 350         


Asp Lys Glu Tyr Lys Leu Asp Arg Ile Leu Arg Arg Leu Asp Glu Leu 
        355                 360                 365             


Ile Lys Gln Leu Ser Arg Ile Leu Glu Glu Ile Glu Arg Leu Val Asp 
    370                 375                 380                 


Glu Leu Glu Arg Glu Pro Leu Asp Asp Lys Glu Val Gln Asp Val Ile 
385                 390                 395                 400 


Glu Arg Ile Val Glu Leu Ile Asp Glu His Leu Glu Leu Leu Lys Glu 
                405                 410                 415     


Tyr Ile Lys Leu Leu Glu Glu Tyr Ile Lys Thr Thr Lys Met Val Ser 
            420                 425                 430         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        435                 440                 445             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    450                 455                 460                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr 
465                 470                 475                 480 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
                485                 490                 495     


Gly Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
            500                 505                 510         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        515                 520                 525             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    530                 535                 540                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
545                 550                 555                 560 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                565                 570                 575     


Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            580                 585                 590         


Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu 
        595                 600                 605             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    610                 615                 620                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp 
625                 630                 635                 640 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                645                 650                 655     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            660                 665             


<210>  74
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Phe Gln Gly Ser Gly Ser Gly Ser Pro Ser Lys Glu Tyr Gln Glu Lys 
1               5                   10                  15      


Ser Ala Glu Arg Gln Lys Glu Leu Leu His Glu Tyr Glu Lys Leu Val 
            20                  25                  30          


Arg His Leu Arg Glu Leu Val Glu Lys Leu Gln Arg Arg Glu Leu Asp 
        35                  40                  45              


Lys Glu Glu Val Leu Arg Arg Leu Val Glu Ile Leu Glu Arg Leu Lys 
    50                  55                  60                  


Asp Leu His Lys Lys Ile Glu Asp Ala His Arg Lys Asn Glu Glu Ala 
65                  70                  75                  80  


His Lys Glu Asn Lys Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr 
                85                  90                  95      


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser 
            100                 105                 110         


Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        115                 120                 125             


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
    130                 135                 140                 


Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
145                 150                 155                 160 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
                165                 170                 175     


Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly 
            180                 185                 190         


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
        195                 200                 205             


Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp 
    210                 215                 220                 


Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys 
225                 230                 235                 240 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val 
                245                 250                 255     


Gln Ser Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
            260                 265                 270         


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
        275                 280                 285             


Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
    290                 295                 300                 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
305                 310                 315                 320 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Ser Gly Ser Asp 
                325                 330                 335     


Lys Glu Tyr Lys Leu Asp Arg Ile Leu Arg Arg Leu Asp Glu Leu Ile 
            340                 345                 350         


Lys Gln Leu Ser Arg Ile Leu Glu Glu Ile Glu Arg Leu Val Asp Glu 
        355                 360                 365             


Leu Glu Arg Glu Pro Leu Asp Asp Lys Glu Val Gln Asp Val Ile Glu 
    370                 375                 380                 


Arg Ile Val Glu Leu Ile Asp Glu His Leu Glu Leu Leu Lys Glu Tyr 
385                 390                 395                 400 


Ile Lys Leu Leu Glu Glu Tyr Ile Lys Thr Thr Lys Met Val Ser Lys 
                405                 410                 415     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            420                 425                 430         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        435                 440                 445             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
    450                 455                 460                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
465                 470                 475                 480 


Val Gln Met Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                485                 490                 495     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            500                 505                 510         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        515                 520                 525             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    530                 535                 540                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
545                 550                 555                 560 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                565                 570                 575     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala 
            580                 585                 590         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        595                 600                 605             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
    610                 615                 620                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
625                 630                 635                 640 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                645                 650     


<210>  75
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Met Gly Ser His His His His His His Gly Ser Gly Ser Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu 
            20                  25                  30          


Lys Ala Ser Thr Ala Glu Leu Lys Arg Ser Thr Ala Ser Leu Arg Ala 
        35                  40                  45              


Ser Thr Glu Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu 
    50                  55                  60                  


Asn Asn Arg Leu Ile Val Glu Asn Asn Ala Ile Ile Val Glu Asn Asn 
65                  70                  75                  80  


Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
                85                  90                  95  


<210>  76
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Gly Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ser 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ser Thr Ala Ser Leu Arg Ala Ser Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg 
        35                  40                  45              


Leu Ile Val Glu Asn Asn Ala Ile Ile Val Glu Asn Asn Arg Ile Ile 
    50                  55                  60                  


Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75      


<210>  77
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg 
            20                  25                  30          


Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu 
        35                  40                  45              


Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu 
    50                  55                  60                  


Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile 
65                  70                  75                  80  


Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala 
                85                  90                  95      


Lys Ser Asp Gly Ser Gly Ser Gly Ser Thr Lys Tyr Glu Leu Arg Arg 
            100                 105                 110         


Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys Lys Ser Leu 
        115                 120                 125             


Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn Pro Ser Glu 
    130                 135                 140                 


Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys Ile Asn Ala 
                165                 170                 175     


Lys Ser Asp Gly Ser Gly Ile His Gly Asn Val Tyr Ile Thr Ala Asp 
            180                 185                 190         


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Gly Leu Asn Ser Asn Val 
        195                 200                 205             


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
    210                 215                 220                 


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
                245                 250                 255     


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
            260                 265                 270         


Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu 
        275                 280                 285             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    290                 295                 300                 


Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr 
305                 310                 315                 320 


Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro 
                325                 330                 335     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Trp Gly Val Gln Ser 
            340                 345                 350         


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        355                 360                 365             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    370                 375                 380                 


Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
385                 390                 395                 400 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                405                 410                 415     


Asn Ile Leu Gly His Lys Leu Glu Tyr Gly Gly Ser Thr Lys Tyr Glu 
            420                 425                 430         


Leu Arg Arg Ala Leu Glu Glu Leu Glu Lys Ala Leu Arg Glu Leu Lys 
        435                 440                 445             


Lys Ser Leu Asp Glu Leu Glu Arg Ser Leu Glu Glu Leu Glu Lys Asn 
    450                 455                 460                 


Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu Asn Val Glu Asn 
465                 470                 475                 480 


Asn Lys Ile Ile Val Glu Val Leu Arg Ile Ile Ala Glu Val Leu Lys 
                485                 490                 495     


Ile Asn Ala Lys Ser Asp Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
            500                 505                 510         


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
        515                 520                 525             


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
    530                 535                 540                 


Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp 
545                 550                 555                 560 


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Met Phe Ala Arg 
                565                 570                 575     


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
            580                 585                 590         


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
        595                 600                 605             


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
    610                 615                 620                 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
625                 630                 635                 640 


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr 
                645                 650                 655     


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
            660                 665                 670         


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        675                 680                 685             


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
    690                 695                 700                 


Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
705                 710                 715                 720 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
                725                 730                 735     


Asp Glu Leu Tyr Lys 
            740     


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pRO-2

<400>  78

His Asn Arg Ile Ile Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile 
1               5                   10                  15      


Lys 
    


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pRO-3

<400>  79

His Asn Lys Ile Ile Ala Glu Val Leu Arg Ile Ile Ala Lys Val Leu 
1               5                   10                  15      


Lys 
    


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pRO-3.1

<400>  80

His Asn Lys Ile Ile Ala Glu His Asn Arg Ile Ile Ala Lys Val Leu 
1               5                   10                  15      


Lys 
    


<210>  81
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polpypeptide

<400>  81

Met Asp Glu Glu Asp His Leu Lys Lys Leu Lys Thr His Leu Glu Lys 
1               5                   10                  15      


Leu Glu Arg His Leu Lys Leu Leu Glu Asp His Ala Lys Lys Leu Glu 
            20                  25                  30          


Asp Ile Leu Lys Glu Arg Pro Glu Asp Ser Ala Val Lys Glu Ser Ile 
        35                  40                  45              


Asp Glu Leu Arg Arg Ser Ile Glu Leu Val Arg Glu Ser Ile Glu Ile 
    50                  55                  60                  


Phe Arg Gln Ser Val Glu Glu Glu Glu 
65                  70              


<210>  82
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polpypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  Optional residues

<400>  82

Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Asp Val Lys Glu Leu Thr Lys Ile Leu Asp Thr Leu Thr 
            20                  25                  30          


Lys Ile Leu Glu Thr Ala Thr Lys Val Ile Lys Asp Ala Thr Lys Leu 
        35                  40                  45              


Leu Glu Glu His Arg Lys Ser Asp Lys Pro Asp Pro Arg Leu Ile Glu 
    50                  55                  60                  


Thr His Lys Lys Leu Val Glu Glu His Glu Thr Leu Val Arg Gln His 
65                  70                  75                  80  


Lys Glu Leu Ala Glu Glu His Leu Lys Arg Thr Arg 
                85                  90          


<210>  83
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polpypeptide

<400>  83

Met Asp Glu Glu Asp His Leu Lys Lys Leu Lys Thr His Leu Glu Lys 
1               5                   10                  15      


Leu Glu Arg His Leu Lys Leu Ala Glu Asp His Ala Lys Lys Leu Glu 
            20                  25                  30          


Asp Ile Leu Lys Glu Arg Pro Glu Asp Ser Ala Val Lys Glu Ser Ile 
        35                  40                  45              


Asp Glu Leu Arg Arg Ser Ile Glu Leu Val Arg Glu Ser Ile Glu Ile 
    50                  55                  60                  


Phe Arg Gln Ser Val Glu Glu Glu Glu 
65                  70              


<210>  84
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polpypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  Optional residues

<400>  84

Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Asp Val Lys Glu Leu Thr Lys Ile Leu Asp Thr Leu Thr 
            20                  25                  30          


Lys Ile Leu Glu Thr Ala Thr Lys Val Ile Lys Asp Ala Thr Lys Leu 
        35                  40                  45              


Leu Glu Glu His Arg Lys Ser Asp Lys Pro Asp Pro Arg Leu Ile Glu 
    50                  55                  60                  


Thr His Lys Lys Leu Val Glu Glu His Glu Thr Leu Ala Arg Gln His 
65                  70                  75                  80  


Lys Glu Leu Ala Glu Glu His Leu Lys Arg Thr Arg 
                85                  90          


<210>  85
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polpypeptide

<400>  85

Met Thr Lys Glu Asp Ile Leu Glu Arg Gln Arg Lys Ile Ile Glu Arg 
1               5                   10                  15      


Ala Gln Glu Ile His Arg Arg Gln Gln Glu Ile Leu Lys Glu Gln Glu 
            20                  25                  30          


Lys Ile Ile Arg Lys Pro Gly Ser Ser Glu Glu Ala Met Lys Arg Ser 
        35                  40                  45              


Leu Lys Leu Ile Glu Glu Ser Leu Arg Leu Leu Lys Glu Leu Leu Glu 
    50                  55                  60                  


Leu Ser Glu Glu Ser Ala Gln Leu Leu Tyr Glu Gln Arg 
65                  70                  75          


<210>  86
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polpypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  Optional residues

<400>  86

Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Thr Glu Lys Arg Leu Leu Glu Glu Ala Glu Arg Ala His 
            20                  25                  30          


Arg Glu Gln Lys Glu Ile Ile Lys Lys Ala Gln Glu Leu His Lys Glu 
        35                  40                  45              


Leu Thr Lys Ile His Gln Gln Ser Gly Ser Ser Glu Glu Ala Lys Lys 
    50                  55                  60                  


Arg Ala Leu Lys Ile Ser Gln Glu Ile Arg Glu Leu Ser Lys Arg Ser 
65                  70                  75                  80  


Leu Glu Leu Leu Arg Glu Ile Leu Tyr Leu Ser Gln Glu Gln Lys 
                85                  90                  95  


