                         SEQUENCE LISTING

<110>  Yale University
       Crawford, Jason
       Goddard, Tyler
       Streeter, Matthew
       Spiegel, David
 
<120>  Advanced Glycation End-Product Breaking Biocatalysts

<130>  047162-7176WO1(01093)

<150>  US 62/836,382
<151>  2019-04-19

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  1

Met Ser Val Ser Lys Pro Asn Pro Leu Gly Ser Val Pro Pro Glu Val 
1               5                   10                  15      


Ala His Arg Val Ala Leu Leu Arg Asp Val Pro Ala Gly Glu Leu Leu 
            20                  25                  30          


Ile His Glu Ile Tyr Lys Ser Ile Gln Gly Glu Ser Thr Phe Ala Gly 
        35                  40                  45              


Leu Pro Cys Val Phe Val Arg Thr Ala Val Cys Asp Ser Arg Cys Lys 
    50                  55                  60                  


Trp Cys Asp Thr Pro His Ala Phe Thr Gln Gly Glu Arg Met Thr Arg 
65                  70                  75                  80  


Ala Ala Val Arg Asp Arg Val Leu Ala Phe Asp Cys Pro Leu Val Glu 
                85                  90                  95      


Ile Thr Gly Gly Glu Pro Leu Leu Gln Thr Asp Ser Tyr Pro Leu Met 
            100                 105                 110         


Ala Glu Leu Ala Asp Ser Gly Lys Ser Val Leu Leu Glu Thr Ser Gly 
        115                 120                 125             


Ala His Asp Val Ala Pro Val Asp Pro Arg Val His Ile Val Leu Asp 
    130                 135                 140                 


Leu Lys Cys Pro Asp Ser Gly Glu Cys Ala Arg Asn Arg Trp Ala Asn 
145                 150                 155                 160 


Leu Asp Ala Leu Lys Pro Thr Asp Glu Ile Lys Phe Val Ile Ala Ser 
                165                 170                 175     


Arg Ser Asp Trp Asp Trp Thr Ala Arg Thr Ile Arg Glu His Arg Leu 
            180                 185                 190         


Asp Asp Arg Phe Gln Cys Leu Ile Ser Ala Val Phe Gly Ala Val Glu 
        195                 200                 205             


Pro Ile Glu Leu Ala Gly Trp Leu Leu Glu Ser Gly Leu Asp Arg Val 
    210                 215                 220                 


Arg Leu Gln Leu Gln Leu His Lys Tyr Ile Trp His Pro Thr Met Arg 
225                 230                 235                 240 


Gly Val 
        


<210>  2
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  2

Met Ala Arg Ala Thr Tyr Leu Glu Asp Thr Cys Lys Thr Ala Leu Asn 
1               5                   10                  15      


Arg Val Pro Asp Ala Ala Arg Val Pro Phe Arg Trp Thr Ile Asn Pro 
            20                  25                  30          


Tyr Arg Gly Cys Thr His Ala Cys His Tyr Cys Phe Ala Arg Ala Phe 
        35                  40                  45              


His Ser Tyr Leu Asp Met Gly Val Gly Glu Asp Phe Ser Thr Lys Ile 
    50                  55                  60                  


Val Ile Lys Thr Asn Leu Val Glu Val Leu Arg Arg Glu Leu Ala Ser 
65                  70                  75                  80  


Pro Lys Trp Thr Gly Glu Val Ile Ala Met Gly Thr Ala Thr Asp Pro 
                85                  90                  95      


Tyr Gln His Cys Glu Gly Arg Phe Arg Leu Thr Arg Gly Val Leu Glu 
            100                 105                 110         


Ala Leu Ile Asp Ala Gly Asn Pro Leu Ser Met Leu Thr Lys Ser Thr 
        115                 120                 125             


Leu Val Val Arg Asp Phe Asp Leu Tyr Val Arg Leu Ala Glu Ile Ala 
    130                 135                 140                 


Asp Val Ser Ile Ala Met Ser Ile Gly Thr Leu Asp Glu Asp Val Arg 
145                 150                 155                 160 


Arg Val Val Glu Pro Gly Thr Pro Pro Gly Glu Lys Arg Leu Glu Ile 
                165                 170                 175     


Leu Ala Arg Phe Ala Ala Ala Gly Ile Arg Thr Gly Val Leu Val Ala 
            180                 185                 190         


Pro Val Leu Pro Gly Leu Thr Asp Asp Asp Glu His Leu Asp Ala Val 
        195                 200                 205             


Leu Ala Ala Cys Ala Glu Ala Gly Ile Asp Trp Ala Thr Val Ile Pro 
    210                 215                 220                 


Leu His Ile Arg Ala Gly Ile Arg Pro His Phe Ile Pro Trp Ile Glu 
225                 230                 235                 240 


Asp Ala Tyr Pro His Leu Ala Lys Arg Tyr Glu Arg Leu Tyr Gly Pro 
                245                 250                 255     


Arg Ala Tyr Ala Pro Arg Gly Tyr Ser Glu Glu Leu Thr Thr Arg Phe 
            260                 265                 270         


Ala Arg Leu Arg Glu Arg His Gly Ile Thr Gly Ser Ala Gly Arg Phe 
        275                 280                 285             


Arg Val Glu Pro Ala Pro Arg Gly Gln Leu Ala Leu Ala Val 
    290                 295                 300         


<210>  3
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  3

Met Phe Thr Asn Asp Glu Gln Ala Ala Val Tyr Lys Ala Ile Tyr Asn 
1               5                   10                  15      


Arg Arg Asp Ile Arg Ser Phe Leu Pro Asp Pro Ile Ser Lys Glu Ile 
            20                  25                  30          


Leu Gln Arg Ile Leu Asp Ala Ala His His Ala Pro Ser Val Gly Phe 
        35                  40                  45              


Met Gln Pro Trp Ser Phe Ile Val Val Ser Ser Gln Glu Ile Lys Asn 
    50                  55                  60                  


Arg Leu Ala Trp Ala Ala Asp Lys Glu Arg Arg Ala Leu Ala Ile His 
65                  70                  75                  80  


Tyr Glu Gly Gly Lys Glu Asn Lys Phe Leu Ser Leu Lys Val Glu Gly 
                85                  90                  95      


Leu Lys Glu Ala Pro Tyr Thr Ile Cys Val Thr Cys Asp Pro Thr Arg 
            100                 105                 110         


Gly Gly Ser His Val Leu Gly Arg Asn Ser Ile Pro Glu Thr Asp Ile 
        115                 120                 125             


Leu Ser Thr Ala Cys Ala Ile Gln Asn Met Trp Leu Ala Ala Cys Ala 
    130                 135                 140                 


Glu Gly Leu Ala Met Gly Trp Val Ser Phe Tyr Lys Lys Asn Asp Ile 
145                 150                 155                 160 


Arg Asp Ile Leu Asp Ile Pro Pro His Val Glu Pro Ile Ala Leu Met 
                165                 170                 175     


Ser Val Gly Tyr Thr Asp Gln Tyr Pro Asp Lys Pro Ile Leu Glu Leu 
            180                 185                 190         


Ala Asn Trp Glu Lys Arg Arg Ser Lys Asp Asp Leu Ile Phe Glu Asp 
        195                 200                 205             


Lys Trp Gly Lys Lys 
    210             


<210>  4
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  4

Met Ala Thr Asp Pro Ala Ile Val Ala Arg Leu Gln Ala Glu Ala Pro 
1               5                   10                  15      


Val Trp Phe Ala Thr Leu Arg Asp Arg Ile Cys Ser Ala Phe Glu Thr 
            20                  25                  30          


Leu Glu Asp Glu Ala Pro Gly Pro Phe Asp Pro Glu Ala Gln Gly Pro 
        35                  40                  45              


Gly Arg Phe Val Arg Lys Pro Trp Glu Arg Lys Asp His Ser Gly Asp 
    50                  55                  60                  


Pro Gly Gly Gly Gly Val Met Ser Met Met Arg Gly Arg Val Phe Glu 
65                  70                  75                  80  


Lys Val Gly Val His Val Ser Thr Val Phe Gly Glu Phe Ala Pro Glu 
                85                  90                  95      


Phe Arg Gly Gln Ile Pro Gly Ser Asp Gln Asp Pro Arg Phe Trp Ala 
            100                 105                 110         


Gly Gly Ile Ser Leu Ile Ala His Pro Trp Asn Pro His Val Pro Thr 
        115                 120                 125             


Val His Met Asn Thr Arg Phe Val Val Thr Thr Arg Pro Trp Phe Gly 
    130                 135                 140                 


Gly Gly Ala Asp Leu Thr Pro Val Leu Asp Arg Arg Arg Thr Gln Asp 
145                 150                 155                 160 


Asp Pro Asp Ser Val Ala Phe His Ser Ala Met Arg His Ala Cys Asp 
                165                 170                 175     


Arg His Ala Ala His Ala Pro Tyr Asp Lys Tyr Lys Ser Trp Cys Asp 
            180                 185                 190         


Glu Tyr Phe Phe Leu Lys His Arg Gln Glu Ser Arg Gly Ile Gly Gly 
        195                 200                 205             


Ile Phe Tyr Asp Tyr His Trp Ser Gly Asp Pro Glu Asp Asp Phe Ala 
    210                 215                 220                 


Phe Thr Arg Asp Val Gly Leu Ala Phe Leu Ala Val Tyr Pro Ala Ile 
225                 230                 235                 240 


Val Arg Arg Asn Phe Ala Thr Pro Trp Thr Glu Ala Asp Arg His Glu 
                245                 250                 255     


Gln Gln Val Arg Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp 
            260                 265                 270         


Arg Gly Thr Ile Phe Gly Leu Lys Thr Gly Gly Asn Ile Glu Ser Ile 
        275                 280                 285             


Leu Ser Ser Met Pro Pro Thr Cys Arg Trp Pro 
    290                 295                 


<210>  5
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  5

Met Pro Asp Thr Thr Phe Ser His Pro Leu Ala Pro Ala Ala Arg Thr 
1               5                   10                  15      


Trp Phe Glu Ser Leu Arg Asp Arg Ile Cys Ala Ala Phe Glu Ser Ile 
            20                  25                  30          


Glu Asp Glu Ala His Gly Pro Ala Pro Ala Gly Arg Phe Gln Arg Lys 
        35                  40                  45              


Ala Trp Glu Arg Glu Gly Gly Gly Gly Gly Val Met Ser Val Met Arg 
    50                  55                  60                  


Gly Arg Val Phe Glu Lys Val Gly Val Asn Val Ser Thr Val Phe Gly 
65                  70                  75                  80  


Glu Phe Ser Pro Glu Phe Arg Lys Ser Ile Pro Gly Ala Glu Ser Asp 
                85                  90                  95      


Pro Arg Phe Ile Ala Thr Gly Val Ser Leu Val Ala His Met Cys Ser 
            100                 105                 110         


Pro Arg Val Pro Ala Val His Met Asn Thr Arg Phe Ile Ala Thr Thr 
        115                 120                 125             


Arg Ala Trp Phe Gly Gly Gly Gly Asp Ile Thr Pro Met Ala Met Asp 
    130                 135                 140                 


Ala Pro Glu Ser Gln Glu Asp Ala Ala Thr Phe His Ala Ala Phe Lys 
145                 150                 155                 160 


Ala Ala Cys Asp Arg His Asp Pro Gly Tyr Tyr Pro Arg Phe Lys Gln 
                165                 170                 175     


Trp Cys Asp Glu Tyr Phe Phe Leu Pro His Arg Asn Glu Pro Arg Gly 
            180                 185                 190         


Leu Gly Gly Ile Phe Tyr Asp Trp Leu Gly Arg Asp Asp Ala Asp Glu 
        195                 200                 205             


Gly Arg Leu Pro Asp His Phe Ala Phe Thr Arg Asp Val Gly Glu Ala 
    210                 215                 220                 


Phe Leu Asn Val Tyr Pro Asp Ile Val Arg Arg Arg Met Ala Glu Pro 
225                 230                 235                 240 


Phe Thr Pro Ala Glu Arg Glu His Gln Leu Leu Arg Arg Gly Arg Tyr 
                245                 250                 255     


Val Glu Phe Asn Leu Leu His Asp Arg Gly Thr Leu Phe Gly Leu Arg 
            260                 265                 270         


Thr Gly Gly Asn Thr Glu Ala Ile Leu Met Ser Leu Pro Pro Glu Val 
        275                 280                 285             


Lys Trp Ala 
    290     


<210>  6
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  6

Met Val Glu Ala Leu Met Ile Gln Ala Asp Pro Ala Leu Met Ile Glu 
1               5                   10                  15      


Arg Arg Glu Arg Ala Arg Val Trp Phe Glu Thr Leu Arg Asp Lys Ile 
            20                  25                  30          


His Ala Gly Phe Glu Ala Leu Glu Asp Ala Ala Pro Ala Glu Leu Phe 
        35                  40                  45              


Thr Gly Glu Pro Gly Arg Phe Val Arg Thr Pro Trp Asp Arg Pro Glu 
    50                  55                  60                  


Gly Gly Gly Gly Val Met Gly Met Met Gly Gly Arg Leu Phe Glu Lys 
65                  70                  75                  80  


Val Gly Val His Cys Ser Thr Val His Gly Thr Phe Pro Ala Asp Tyr 
                85                  90                  95      


Ala Lys Asn Val Pro Gly Ala Glu Glu Asp Pro Arg Phe Tyr Ala Thr 
            100                 105                 110         


Gly Ile Ser Leu Ile Cys His Pro Val Ser Pro Arg Val Pro Ala Val 
        115                 120                 125             


His Met Asn Thr Arg Leu Ile Ser Thr Thr Lys Thr Trp Phe Gly Gly 
    130                 135                 140                 


Gly Gly Asp Leu Thr Pro Val Leu Asp Ala Asp Arg Arg Asp Asp His 
145                 150                 155                 160 


Pro Asp Thr Val Asp Phe His Ala Ala Met Lys Gly Ala Cys Asp Ala 
                165                 170                 175     


Phe Asp Pro Ala Trp His Ala Lys Tyr Lys Gln Trp Cys Asp Glu Tyr 
            180                 185                 190         


Phe Phe Leu Pro His Arg Asn Glu Pro Arg Gly Thr Gly Gly Ile Phe 
        195                 200                 205             


Tyr Asp His His Asp Ser Gly Asp Trp Glu Lys Asp Phe Ala Phe Thr 
    210                 215                 220                 


Gln Ala Val Gly Glu Ala Phe Leu Lys Val Tyr Ser Asp Ile Val Ala 
225                 230                 235                 240 


Arg Arg Met Gln Glu Pro Trp Asn Asp Ala Glu Arg Glu Glu Gln Leu 
                245                 250                 255     


Ile Arg Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp Arg Gly 
            260                 265                 270         


Thr Met Phe Gly Leu Lys Thr Gly Gly Asn Val Glu Ser Ile Leu Ser 
        275                 280                 285             


Ser Met Pro Pro Val Val Lys Trp Pro 
    290                 295         


<210>  7
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  7

Met Asp Val Ser Leu Leu Glu Asn Arg Lys Thr Thr Ala Arg Ala Trp 
1               5                   10                  15      


Phe Glu Lys Leu Arg Asp Asp Ile Cys Ala Ser Tyr Glu Arg Leu Glu 
            20                  25                  30          


Asp Glu Ala Pro Ala Ser Leu Tyr Gly Asp Lys Ala Gly Arg Phe Glu 
        35                  40                  45              


Arg Thr Pro Trp Glu Arg Ser Asp His Thr Gly Ala Pro Gly Gly Gly 
    50                  55                  60                  


Gly Val Met Ser Ile Met Arg Gly Arg Leu Phe Glu Lys Val Gly Val 
65                  70                  75                  80  


His Cys Ser Thr Val Phe Gly Glu Phe Ala Pro Glu Phe Arg Ala Gln 
                85                  90                  95      


Ile Pro Gly Ala Ala Asp Asp Pro Arg Phe Trp Ala Ser Gly Ile Ser 
            100                 105                 110         


Leu Ile Ala His Pro Arg Asn Pro Asn Val Pro Ala Val His Met Asn 
        115                 120                 125             


Thr Arg Phe Val Val Thr Thr Lys Arg Trp Phe Gly Gly Gly Ala Asp 
    130                 135                 140                 


Leu Thr Pro Val Leu Asp Arg Arg Arg Thr Gln Glu Asp Pro Asp Thr 
145                 150                 155                 160 


Ile Ser Phe His Glu Ala Phe Arg Lys Ala Cys His Ala His Thr Ala 
                165                 170                 175     


Val Ala Pro Tyr Asp Lys Phe Lys Lys Trp Cys Asp Asp Tyr Phe Phe 
            180                 185                 190         


Leu Ala His Arg Lys Glu Pro Arg Gly Ile Gly Gly Ile Phe Tyr Asp 
        195                 200                 205             


Trp Leu Glu Ser Gly Asp Trp Asn Ala Asp Phe Ala Phe Thr Gln Asp 
    210                 215                 220                 


Val Gly Arg Thr Phe Ala Ala Ile Tyr Pro Glu Leu Val Arg Arg Asn 
225                 230                 235                 240 


Phe Glu Thr Pro Trp Gln Pro Ala Asp Arg Glu Glu Gln Leu Val Arg 
                245                 250                 255     


Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp Arg Gly Thr Ile 
            260                 265                 270         


Phe Gly Leu Lys Thr Gly Gly Asn Val Glu Ser Ile Leu Ser Ser Met 
        275                 280                 285             


Pro Pro Glu Val Lys Trp Pro 
    290                 295 


<210>  8
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  8

Met Ala Pro Pro Val Thr Asp Leu Gly Glu Leu Arg Arg Arg Pro Gly 
1               5                   10                  15      


Asp Met Lys Thr Lys Met Glu Leu Leu Ile Leu Glu Thr Gln Ala Gln 
            20                  25                  30          


Val Cys Gln Ala Leu Ala Gln Val Asp Gly Gly Ala Asn Phe Ser Val 
        35                  40                  45              


Asp Arg Trp Glu Arg Lys Glu Gly Gly Gly Gly Ile Ser Cys Val Leu 
    50                  55                  60                  


Gln Asp Gly Cys Val Phe Glu Lys Ala Gly Val Ser Ile Ser Val Val 
65                  70                  75                  80  


His Gly Asn Leu Ser Glu Glu Ala Ala Lys Gln Met Arg Ser Arg Gly 
                85                  90                  95      


Lys Val Leu Lys Thr Lys Asp Gly Lys Leu Pro Phe Cys Ala Met Gly 
            100                 105                 110         


Val Ser Ser Val Ile His Pro Lys Asn Pro His Ala Pro Thr Ile His 
        115                 120                 125             


Phe Asn Tyr Arg Tyr Phe Glu Val Glu Glu Ala Asp Gly Asn Lys Gln 
    130                 135                 140                 


Trp Trp Phe Gly Gly Gly Cys Asp Leu Thr Pro Thr Tyr Leu Asn Gln 
145                 150                 155                 160 


Glu Asp Ala Val His Phe His Arg Thr Leu Lys Glu Ala Cys Asp Gln 
                165                 170                 175     


His Gly Pro Asp Leu Tyr Pro Lys Phe Lys Lys Trp Cys Asp Asp Tyr 
            180                 185                 190         


Phe Phe Ile Ala His Arg Gly Glu Arg Arg Gly Ile Gly Gly Ile Phe 
        195                 200                 205             


Phe Asp Asp Leu Asp Ser Pro Ser Lys Glu Glu Val Phe Arg Phe Val 
    210                 215                 220                 


Gln Ser Cys Ala Arg Ala Val Val Pro Ser Tyr Ile Pro Leu Val Lys 
225                 230                 235                 240 


Lys His Cys Asp Asp Ser Phe Thr Pro Gln Glu Lys Leu Trp Gln Gln 
                245                 250                 255     


Leu Arg Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp Arg Gly 
            260                 265                 270         


Thr Lys Phe Gly Leu Phe Thr Pro Gly Ser Arg Ile Glu Ser Ile Leu 
        275                 280                 285             


Met Ser Leu Pro Leu Thr Ala Arg Trp Glu Tyr Met His Ser Pro Ser 
    290                 295                 300                 


Glu Asn Ser Lys Glu Ala Glu Ile Leu Glu Val Leu Arg His Pro Arg 
305                 310                 315                 320 


Asp Trp Val Arg 
                


<210>  9
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  9

Met Asp Thr Gln Ala Val Arg Ala Tyr Leu Leu Asp Leu Gln Asp Arg 
1               5                   10                  15      


Ile Thr Thr Ala Ala Ser Ala Leu Asp Gly Gly Thr Phe Val Thr Asp 
            20                  25                  30          


Ala Trp Glu Lys Pro Pro Thr Glu Arg Leu Arg Gly Ser Gly Arg Thr 
        35                  40                  45              


Arg Ile Leu Glu Gly Gly Ala Leu Leu Glu Arg Gly Gly Val Gly Phe 
    50                  55                  60                  


Ser His Val Met Gly Asp Thr Leu Pro Pro Ser Ala Thr Ala Asn Arg 
65                  70                  75                  80  


Pro Glu Leu Ala Gly Arg Gly Phe Glu Ala Met Gly Val Ser Leu Val 
                85                  90                  95      


Phe His Pro Arg Asn Pro Tyr Val Pro Thr Val His Met Asn Val Arg 
            100                 105                 110         


Cys Phe Val Ala Val Arg Ser Asp Ala Ala Pro Val Trp Trp Phe Gly 
        115                 120                 125             


Gly Gly Met Asp Leu Thr Pro Tyr Tyr Gly Phe Thr Glu Asp Ala Ser 
    130                 135                 140                 


His Phe His Arg Thr Cys Gln Gly Ala Leu Ala Pro Tyr Gly Asp Glu 
145                 150                 155                 160 


Leu Tyr Pro Arg Phe Lys Gln Trp Cys Asp Asp Tyr Phe Tyr Leu Lys 
                165                 170                 175     


His Arg Lys Glu Ala Arg Gly Ile Gly Gly Ile Phe Phe Asp Asp Phe 
            180                 185                 190         


Ala Glu Leu Gly Phe Glu Arg Ser Phe Glu Met Met Arg Ser Val Gly 
        195                 200                 205             


Asp Ala Phe Leu Pro Ala Trp Leu Pro Ile Ala Glu Gln Arg His Ala 
    210                 215                 220                 


Thr Ala Tyr Gly Glu Arg Glu Arg Ala Phe Gln Ala Tyr Arg Arg Gly 
225                 230                 235                 240 


Arg Tyr Val Glu Phe Asn Leu Val Phe Asp Arg Gly Thr Leu Phe Gly 
                245                 250                 255     


Leu Gln Ser Gly Gly Arg Ala Glu Ser Ile Leu Met Ser Met Pro Pro 
            260                 265                 270         


Val Ala Asn Trp Arg Tyr Asp Trp Gln Pro Glu Pro Gly Ser Pro Glu 
        275                 280                 285             


Ala Ala Leu Tyr Thr Asp Phe Leu Pro Ala Arg Asp Trp Val 
    290                 295                 300         


<210>  10
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  10

Met Lys Pro Asp Ala His Gln Val Lys Gln Phe Leu Leu Asn Leu Gln 
1               5                   10                  15      


Asp Thr Ile Cys Gln Gln Leu Thr Ala Val Asp Gly Ala Glu Phe Val 
            20                  25                  30          


Glu Asp Ser Trp Gln Arg Glu Ala Gly Gly Gly Gly Arg Ser Arg Val 
        35                  40                  45              


Leu Arg Asn Gly Gly Val Phe Glu Gln Ala Gly Val Asn Phe Ser His 
    50                  55                  60                  


Val His Gly Glu Ala Met Pro Ala Ser Ala Thr Ala His Arg Pro Glu 
65                  70                  75                  80  


Leu Ala Gly Arg Ser Phe Glu Ala Met Gly Val Ser Leu Val Val His 
                85                  90                  95      


Pro His Asn Pro Tyr Val Pro Thr Ser His Ala Asn Val Arg Phe Phe 
            100                 105                 110         


Ile Ala Glu Lys Pro Gly Ala Asp Pro Val Trp Trp Phe Gly Gly Gly 
        115                 120                 125             


Phe Asp Leu Thr Pro Phe Tyr Gly Phe Glu Glu Asp Ala Ile His Trp 
    130                 135                 140                 


His Arg Thr Ala Arg Asp Leu Cys Leu Pro Phe Gly Glu Asp Val Tyr 
145                 150                 155                 160 


Pro Arg Tyr Lys Lys Trp Cys Asp Glu Tyr Phe Tyr Leu Lys His Arg 
                165                 170                 175     


Asn Glu Gln Arg Gly Ile Gly Gly Leu Phe Phe Asp Asp Leu Asn Thr 
            180                 185                 190         


Pro Asp Phe Asp Arg Cys Phe Ala Phe Met Gln Ala Val Gly Lys Gly 
        195                 200                 205             


Tyr Thr Asp Ala Tyr Leu Pro Ile Val Glu Arg Arg Lys Ala Met Ala 
    210                 215                 220                 


Tyr Gly Glu Arg Glu Arg Asn Phe Gln Leu Tyr Arg Arg Gly Arg Tyr 
225                 230                 235                 240 


Val Glu Phe Asn Leu Val Trp Asp Arg Gly Thr Leu Phe Gly Leu Gln 
                245                 250                 255     


Thr Gly Gly Arg Thr Glu Ser Ile Leu Met Ser Met Pro Pro Leu Val 
            260                 265                 270         


Arg Trp Glu Tyr Asp Tyr Gln Pro Lys Asp Gly Ser Pro Glu Ala Ala 
        275                 280                 285             


Leu Ser Glu Phe Ile Lys Val Arg Asp Trp Val 
    290                 295                 


<210>  11
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  11

Met Thr Asp Arg Ile Ala Ala Val Lys Thr Tyr Leu Leu Asp Leu Gln 
1               5                   10                  15      


Asp Arg Ile Cys Ala Ala Leu Glu Ala Glu Asp Gly Lys Ala Arg Phe 
            20                  25                  30          


Ala Glu Asp Ala Trp Glu Arg Pro Ala Gly Gly Gly Gly Arg Thr Arg 
        35                  40                  45              


Val Ile Gly Asp Gly Ala Leu Ile Glu Lys Gly Gly Val Asn Phe Ser 
    50                  55                  60                  


His Val Phe Gly Asp Ser Leu Pro Pro Ser Ala Ser Ala His Arg Pro 
65                  70                  75                  80  


Glu Leu Ala Gly Arg Gly Phe Gln Ala Leu Gly Val Ser Leu Val Ile 
                85                  90                  95      


His Pro Glu Asn Pro His Val Pro Thr Ser His Ala Asn Val Arg Phe 
            100                 105                 110         


Phe Cys Ala Glu Lys Glu Gly Glu Glu Pro Val Trp Trp Phe Gly Gly 
        115                 120                 125             


Gly Phe Asp Leu Thr Pro Tyr Tyr Ala His Glu Glu Asp Cys Val His 
    130                 135                 140                 


Trp His Arg Val Ala Arg Asp Ala Cys Ala Pro Phe Gly Ala Asp Val 
145                 150                 155                 160 


Tyr Pro Arg Tyr Lys Glu Trp Cys Asp Arg Tyr Phe His Leu Lys His 
                165                 170                 175     


Arg Asn Glu Pro Arg Gly Ile Gly Gly Leu Phe Phe Asp Asp Leu Asn 
            180                 185                 190         


Gln Trp Asp Phe Asp Thr Cys Phe Ala Phe Ile Arg Ala Ile Gly Asp 
        195                 200                 205             


Ala Tyr Ile Asp Ala Tyr Leu Pro Ile Val Gln Arg Arg Lys His Thr 
    210                 215                 220                 


Pro Phe Asp Glu Arg Gln Arg Glu Phe Gln Ala Tyr Arg Arg Gly Arg 
225                 230                 235                 240 


Tyr Val Glu Phe Asn Leu Val Phe Asp Arg Gly Thr Leu Phe Gly Leu 
                245                 250                 255     


Gln Ser Gly Gly Arg Thr Glu Ser Ile Leu Met Ser Leu Pro Pro Gln 
            260                 265                 270         


Val Arg Trp Gly Tyr Asp Trp Lys Pro Glu Pro Gly Ser Glu Glu Ala 
        275                 280                 285             


Arg Leu Thr Glu Tyr Phe Leu Ala Asp Arg Asp Trp Leu Ala Gly Gln 
    290                 295                 300                 


Pro 
305 


<210>  12
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  12

Met Lys His Tyr Ser Ile Gln Pro Ala Asn Leu Glu Phe Asn Ala Glu 
1               5                   10                  15      


Gly Thr Pro Val Ser Arg Asp Phe Asp Asp Val Tyr Phe Ser Asn Asp 
            20                  25                  30          


Asn Gly Leu Glu Glu Thr Arg Tyr Val Phe Leu Gly Gly Asn Gln Leu 
        35                  40                  45              


Glu Val Arg Phe Pro Glu His Pro His Pro Leu Phe Val Val Ala Glu 
    50                  55                  60                  


Ser Gly Phe Gly Thr Gly Leu Asn Phe Leu Thr Leu Trp Gln Ala Phe 
65                  70                  75                  80  


Asp Gln Phe Arg Glu Ala His Pro Gln Ala Gln Leu Gln Arg Leu His 
                85                  90                  95      


Phe Ile Ser Phe Glu Lys Phe Pro Leu Thr Arg Ala Asp Leu Ala Leu 
            100                 105                 110         


Ala His Gln His Trp Pro Glu Leu Ala Pro Trp Ala Glu Gln Leu Gln 
        115                 120                 125             


Ala Gln Trp Pro Met Pro Leu Pro Gly Cys His Arg Leu Leu Leu Asp 
    130                 135                 140                 


Glu Gly Arg Val Thr Leu Asp Leu Trp Phe Gly Asp Ile Asn Glu Leu 
145                 150                 155                 160 


Thr Ser Gln Leu Asp Asp Ser Leu Asn Gln Lys Val Asp Ala Trp Phe 
                165                 170                 175     


Leu Asp Gly Phe Ala Pro Ala Lys Asn Pro Asp Met Trp Thr Gln Asn 
            180                 185                 190         


Leu Phe Asn Ala Met Ala Arg Leu Ala Arg Pro Gly Gly Thr Leu Ala 
        195                 200                 205             


Thr Phe Thr Ser Ala Gly Phe Val Arg Arg Gly Leu Gln Asp Ala Gly 
    210                 215                 220                 


Phe Thr Met Gln Lys Arg Lys Gly Phe Gly Arg Lys Arg Glu Met Leu 
225                 230                 235                 240 


Cys Gly Val Met Glu Gln Thr Leu Pro Leu Pro Cys Ser Ala Pro Trp 
                245                 250                 255     


Phe Asn Arg Thr Gly Ser Ser Lys Arg Glu Ala Ala Ile Ile Gly Gly 
            260                 265                 270         


Gly Ile Ala Ser Ala Leu Leu Ser Leu Ala Leu Leu Arg Arg Gly Trp 
        275                 280                 285             


Gln Val Thr Leu Tyr Cys Ala Asp Glu Ala Pro Ala Leu Gly Ala Ser 
    290                 295                 300                 


Gly Asn Arg Gln Gly Ala Leu Tyr Pro Leu Leu Ser Lys His Asp Glu 
305                 310                 315                 320 


Ala Leu Asn Arg Phe Phe Ser Asn Ala Phe Thr Phe Ala Arg Arg Phe 
                325                 330                 335     


Tyr Asp Gln Leu Pro Val Lys Phe Asp His Asp Trp Cys Gly Val Thr 
            340                 345                 350         


Gln Leu Gly Trp Asp Glu Lys Ser Gln His Lys Ile Ala Gln Met Leu 
        355                 360                 365             


Ser Met Asp Leu Pro Ala Glu Leu Ala Val Ala Val Glu Ala Asn Ala 
    370                 375                 380                 


Val Glu Gln Ile Thr Gly Val Ala Thr Asn Cys Ser Gly Ile Thr Tyr 
385                 390                 395                 400 


Pro Gln Gly Gly Trp Leu Cys Pro Ala Glu Leu Thr Arg Asn Val Leu 
                405                 410                 415     


Glu Leu Ala Gln Gln Gln Gly Leu Gln Ile Tyr Tyr Gln Tyr Gln Leu 
            420                 425                 430         


Gln Asn Leu Ser Arg Lys Asp Asp Cys Trp Leu Leu Asn Phe Ala Gly 
        435                 440                 445             


Asp Gln Gln Ala Thr His Ser Val Val Val Leu Ala Asn Gly His Gln 
    450                 455                 460                 


Ile Ser Arg Phe Ser Gln Thr Ser Thr Leu Pro Val Tyr Ser Val Ala 
465                 470                 475                 480 


Gly Gln Val Ser His Ile Pro Thr Thr Pro Glu Leu Ala Glu Leu Lys 
                485                 490                 495     


Gln Val Leu Cys Tyr Asp Gly Tyr Leu Thr Pro Gln Asn Pro Ala Asn 
            500                 505                 510         


Gln His His Cys Ile Gly Ala Ser Tyr His Arg Gly Ser Glu Asp Thr 
        515                 520                 525             


Ala Tyr Ser Glu Asp Asp Gln Gln Gln Asn Arg Gln Arg Leu Ile Asp 
    530                 535                 540                 


Cys Phe Pro Gln Ala Gln Trp Ala Lys Glu Val Asp Val Ser Asp Lys 
545                 550                 555                 560 


Glu Ala Arg Cys Gly Val Arg Cys Ala Thr Arg Asp His Leu Pro Met 
                565                 570                 575     


Val Gly Asn Val Pro Asp Tyr Glu Ala Thr Leu Val Glu Tyr Ala Ser 
            580                 585                 590         


Leu Ala Glu Gln Lys Asp Glu Ala Val Ser Ala Pro Val Phe Asp Asp 
        595                 600                 605             


Leu Phe Met Phe Ala Ala Leu Gly Ser Arg Gly Leu Cys Ser Ala Pro 
    610                 615                 620                 


Leu Cys Ala Glu Ile Leu Ala Ala Gln Met Ser Asp Glu Pro Ile Pro 
625                 630                 635                 640 


Met Asp Ala Ser Thr Leu Ala Ala Leu Asn Pro Asn Arg Leu Trp Val 
                645                 650                 655     


Arg Lys Leu Leu Lys Gly Lys Ala Val Lys Ala Gly 
            660                 665             


<210>  13
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  13

Pro Cys Ser Ala Pro Trp Phe Asn Arg Thr Gly Ser Ser Lys Arg Glu 
1               5                   10                  15      


Ala Ala Ile Ile Gly Gly Gly Ile Ala Ser Ala Leu Leu Ser Leu Ala 
            20                  25                  30          


Leu Leu Arg Arg Gly Trp Gln Val Thr Leu Tyr Cys Ala Asp Glu Ala 
        35                  40                  45              


Pro Ala Leu Gly Ala Ser Gly Asn Arg Gln Gly Ala Leu Tyr Pro Leu 
    50                  55                  60                  


Leu Ser Lys His Asp Glu Ala Leu Asn Arg Phe Phe Ser Asn Ala Phe 
65                  70                  75                  80  


Thr Phe Ala Arg Arg Phe Tyr Asp Gln Leu Pro Val Lys Phe Asp His 
                85                  90                  95      


Asp Trp Cys Gly Val Thr Gln Leu Gly Trp Asp Glu Lys Ser Gln His 
            100                 105                 110         


Lys Ile Ala Gln Met Leu Ser Met Asp Leu Pro Ala Glu Leu Ala Val 
        115                 120                 125             


Ala Val Glu Ala Asn Ala Val Glu Gln Ile Thr Gly Val Ala Thr Asn 
    130                 135                 140                 


Cys Ser Gly Ile Thr Tyr Pro Gln Gly Gly Trp Leu Cys Pro Ala Glu 
145                 150                 155                 160 


Leu Thr Arg Asn Val Leu Glu Leu Ala Gln Gln Gln Gly Leu Gln Ile 
                165                 170                 175     


Tyr Tyr Gln Tyr Gln Leu Gln Asn Leu Ser Arg Lys Asp Asp Cys Trp 
            180                 185                 190         


Leu Leu Asn Phe Ala Gly Asp Gln Gln Ala Thr His Ser Val Val Val 
        195                 200                 205             


Leu Ala Asn Gly His Gln Ile Ser Arg Phe Ser Gln Thr Ser Thr Leu 
    210                 215                 220                 


Pro Val Tyr Ser Val Ala Gly Gln Val Ser His Ile Pro Thr Thr Pro 
225                 230                 235                 240 


Glu Leu Ala Glu Leu Lys Gln Val Leu Cys Tyr Asp Gly Tyr Leu Thr 
                245                 250                 255     


Pro Gln Asn Pro Ala Asn Gln His His Cys Ile Gly Ala Ser Tyr His 
            260                 265                 270         


Arg Gly Ser Glu Asp Thr Ala Tyr Ser Glu Asp Asp Gln Gln Gln Asn 
        275                 280                 285             


Arg Gln Arg Leu Ile Asp Cys Phe Pro Gln Ala Gln Trp Ala Lys Glu 
    290                 295                 300                 


Val Asp Val Ser Asp Lys Glu Ala Arg Cys Gly Val Arg Cys Ala Thr 
305                 310                 315                 320 


Arg Asp His Leu Pro Met Val Gly Asn Val Pro Asp Tyr Glu Ala Thr 
                325                 330                 335     


Leu Val Glu Tyr Ala Ser Leu Ala Glu Gln Lys Asp Glu Ala Val Ser 
            340                 345                 350         


Ala Pro Val Phe Asp Asp Leu Phe Met Phe Ala Ala Leu Gly Ser Arg 
        355                 360                 365             


Gly Leu Cys Ser Ala Pro Leu Cys Ala Glu Ile Leu Ala Ala Gln Met 
    370                 375                 380                 


Ser Asp Glu Pro Ile Pro Met Asp Ala Ser Thr Leu Ala Ala Leu Asn 
385                 390                 395                 400 


Pro Asn Arg Leu Trp Val Arg Lys Leu Leu Lys Gly Lys Ala Val Lys 
                405                 410                 415     


Ala Gly 
        


<210>  14
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  14
atgagcgtgt cgaagccgaa cccactgggg agtgtgccgc cggaggtggc gcatcgcgtc       60

gcgcttttgc gcgacgtgcc ggcgggcgaa ctgctcatcc acgagatcta caagagcatc      120

caaggggaat cgactttcgc gggcctgccg tgcgtgttcg tccgcacggc cgtgtgcgac      180

tcgcgctgca agtggtgcga tacgccgcac gccttcacgc agggcgaacg catgacgcgc      240

gccgcggtgc gcgatcgcgt gctcgctttc gattgtcccc tggtcgagat caccggcgga      300

gagccgctcc ttcagaccga cagctatccg ctcatggctg aactggccga ttcaggcaag      360

agcgtgctgc tcgaaacgag cggcgcgcac gatgtcgcac cagtcgatcc gcgcgttcac      420

atcgttctcg atctgaagtg cccggacagc ggcgaatgcg cgcgcaaccg ctgggcgaac      480

ctggatgcgc tcaagccgac cgacgagatc aagttcgtca tcgcctcgcg aagcgattgg      540

gactggacgg cgcgaacgat tcgcgagcat cgactcgacg accgcttcca atgcctcatc      600

agcgccgtct tcggggcggt cgagccgatc gagctggccg gctggctgct cgaatccggt      660

ctcgatcgcg ttcgacttca gctccaactc cataagtaca tctggcatcc aacgatgcgc      720

ggagtttga                                                              729


<210>  15
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  15
atggcgaggg cgacgtacct cgaggacacc tgcaagacgg cgctgaaccg cgtccccgac       60

gccgcccgcg tgcccttccg ctggacgatc aacccctacc gcggctgcac gcacgcctgc      120

cactactgct tcgcgcgcgc ctttcacagc tacttggata tgggcgtggg ggaggacttc      180

tcgaccaaga tcgtcatcaa gacgaacctg gtcgaggtgc tgcgccgcga gctcgcctcg      240

ccgaaatgga cgggcgaggt gatcgccatg ggaaccgcga ccgacccgta ccagcactgc      300

gagggacgat tccgcctcac ccgcggcgtg ctcgaggcgc tcatcgacgc cggcaacccg      360

ctctcgatgc tcacgaagtc gacgctcgtc gtccgcgact tcgatctgta cgtgcggctc      420

gccgagatcg ccgacgtgag catcgcgatg agcatcggca cgctcgacga ggacgtccgc      480

cgggtcgtcg aaccggggac gccgccgggg gagaagcgcc tcgagatcct cgcccggttc      540

gccgcggccg ggatccgcac cggcgtgctc gtggcgcccg ttctcccggg gctcaccgac      600

gacgacgagc acctcgacgc ggtgctggct gcgtgcgcgg aagcggggat cgactgggcc      660

acggtcatcc cgctccacat ccgcgccggg atccgcccgc acttcatccc gtggatcgaa      720

gacgcgtatc cgcacctcgc caagcgctac gagcggctct acggaccgag ggcgtacgcg      780

ccgcgcgggt actccgagga gctgaccacc aggttcgcgc gcctgcgcga gcgccacggg      840

atcaccgggt cagcggggcg gttccgtgtc gagccggcgc cgcgggggca gctggccctc      900

gcggtctag                                                              909


<210>  16
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  16
atgtttacta atgacgaaca agcagccgta tataaagcta tttataaccg aagggatatc       60

aggagttttt tacccgatcc catttcaaag gaaatactgc aaagaatttt ggatgcggca      120

caccatgccc cgtctgtagg atttatgcaa ccttggagtt ttattgttgt ttcatctcag      180

gaaatcaaaa accgcttggc ctgggcagcc gataaagaga gaagagcgct cgcaattcat      240

tatgaaggcg gaaaagaaaa taaatttctt agtttgaaag ttgaagggtt aaaagaagca      300

ccatatacca tctgtgtaac ctgtgaccct acacggggag gttcccatgt gttggggcgg      360

aactcgattc cagaaaccga tattctttcc actgcctgtg cgattcagaa tatgtggcta      420

gctgcctgtg ccgagggatt agcaatgggg tgggtcagct tttacaagaa aaatgatatc      480

cgtgatattt tggatatacc gccgcacgtt gagcctatcg cacttatgtc ggttggctat      540

actgatcaat acccggataa acctattctt gaattagcca actgggaaaa gagacggtct      600

aaggatgatc ttatttttga agataagtgg ggtaaaaaat aa                         642


<210>  17
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  17
atggccactg accccgccat cgttgcccgc cttcaggccg aggcgcccgt ctggttcgcg       60

accctgcggg accggatctg ctccgccttc gagacgctcg aggacgaggc gcccggcccg      120

ttcgatcccg aagcccaggg ccccggccgc ttcgtgcgca agccatggga gcgcaaggac      180

cacagcggcg acccgggcgg gggcggcgtc atgtcgatga tgcggggccg cgtcttcgag      240

aaggtgggtg tccacgtctc gacggtcttc ggggagttcg cgcccgagtt ccgcggccag      300

atccccggat ctgaccagga tccgcggttc tgggccggcg ggatctcgct catcgcccat      360

ccctggaacc ctcatgtccc gacggtgcac atgaacaccc gcttcgtggt gacgacgagg      420

ccctggttcg ggggcggggc agatctcacg cccgtcctcg accggcgccg gacgcaggac      480

gaccccgaca gcgtcgcctt ccacagcgcc atgcggcatg cctgcgatcg tcacgccgcc      540

catgcgcctt acgacaagta caagagctgg tgcgacgagt acttcttcct caagcaccgg      600

caggagtccc gcgggatcgg cgggatcttc tacgactatc actggtccgg cgaccccgag      660

gacgatttcg ccttcacgcg cgatgtaggc ctcgccttcc tggcggtcta cccggcgatc      720

gtgcggcgca acttcgcgac gccgtggacg gaggcggacc gtcacgagca gcaggtgcgc      780

cggggccgct acgtcgagtt caacctgctc tatgaccgcg gcacgatctt cgggctgaag      840

accggaggca acatcgagtc gatcctctcc tccatgcccc cgacctgccg ctggccgtga      900


<210>  18
<211>  876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  18
atgccggaca ccacctttag ccacccgtta gcaccggcag cacgcacttg gttcgaaagt       60

ctgcgtgatc gcatttgcgc agccttcgag agcatcgaag atgaagcaca tggtccggca      120

ccggctggtc gctttcagcg taaggcatgg gaacgtgaag gcggcggtgg tggtgttatg      180

agcgttatgc gcggccgcgt gttcgaaaaa gtgggcgtga acgtgagtac cgttttcggt      240

gagttcagcc cggaattccg caaaagcatt ccgggtgcag agagcgatcc tcgctttatt      300

gccaccggtg tgtctttagt ggcacatatg tgtagcccgc gcgtgccggc cgttcacatg      360

aatacccgct ttatcgccac cacacgcgca tggtttggtg gcggcggtga tattaccccg      420

atggccatgg atgccccgga aagccaagaa gatgccgcca catttcacgc agcctttaaa      480

gccgcatgcg atcgccacga tccgggctat tatcctcgct tcaaacagtg gtgcgacgag      540

tacttctttt taccgcatcg caatgaacct cgcggtctgg gtggtatctt ctatgattgg      600

ctgggtcgcg atgatgccga tgaaggtcgt ttaccggatc attttgcctt tacccgtgat      660

gtgggcgaag catttttaaa tgtgtacccg gacatcgttc gccgtcgcat ggcagaaccg      720

tttacaccgg ccgaacgcga acaccagctg ctgcgtcgtg gccgctatgt tgagttcaat      780

ttactgcacg atcgcggcac tttatttggt ctgcgcaccg gtggtaacac cgaagccatt      840

ttaatgtctt taccgccgga agtgaaatgg gcctaa                                876


<210>  19
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  19
atggtggaag ctttaatgat tcaagctgat ccggccttaa tgattgaacg tcgcgaacgc       60

gcacgcgttt ggttcgagac tttacgcgac aaaattcatg ctggttttga agcactggaa      120

gatgcagccc cggccgaact gtttaccggt gagccgggcc gctttgtgcg tacaccgtgg      180

gatcgtccgg aaggtggcgg cggtgttatg ggcatgatgg gtggccgttt attcgagaaa      240

gtgggcgtgc attgcagtac cgtgcatggc acctttccgg cagactacgc caaaaatgtg      300

ccgggtgccg aagaggatcc gcgcttttac gccaccggca tctctttaat ttgtcatccg      360

gttagcccgc gtgtgccggc agtgcatatg aacacccgtc tgatcagcac caccaaaact      420

tggtttggtg gtggtggcga tctgaccccc gttctggatg ccgatcgccg cgatgaccat      480

ccggacaccg tggatttcca tgcagccatg aaaggcgctt gtgatgcatt tgatccggct      540

tggcacgcca aatacaagca gtggtgcgac gaatacttct ttttaccgca ccgtaatgaa      600

ccgcgtggta ccggcggcat cttctatgac catcacgata gtggcgactg ggaaaaagac      660

ttcgccttca cccaagctgt gggcgaggcc tttttaaaag tgtacagcga cattgtggca      720

cgccgtatgc aagaaccgtg gaacgacgca gaacgtgaag aacagctgat tcgtcgcggc      780

cgttacgtgg agtttaatct gctgtacgat cgcggcacca tgtttggttt aaagaccggc      840

ggcaatgtgg aaagcatttt aagcagtatg ccgccggtgg tgaaatggcc gtaa            894


<210>  20
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  20
atggatgtgt ctttactgga aaatcgtaaa accaccgccc gtgcttggtt cgaaaaactg       60

cgcgacgata tctgtgccag ctatgagcgt ctggaagatg aggccccggc cagtctgtat      120

ggcgataaag ccggccgctt tgaacgtacc ccgtgggagc gtagcgatca taccggcgca      180

ccgggtggtg gtggtgtgat gagcatcatg cgtggtcgtt tattcgaaaa ggtgggcgtt      240

cattgcagca ccgtgtttgg cgaattcgcc ccggaattcc gcgcccagat tccgggtgca      300

gccgatgatc cgcgcttttg ggcaagcggc atttctttaa ttgcccaccc gcgtaatccg      360

aatgttcccg ctgtgcacat gaacacccgc tttgtggtga ccaccaaacg ctggtttggc      420

ggtggtgccg atctgacacc cgttctggat cgtcgtcgca cccaagaaga tccggatacc      480

attagcttcc acgaggcatt ccgcaaagca tgtcatgccc ataccgccgt ggcaccgtat      540

gataagttca aaaaatggtg cgacgactat ttctttttag cccatcgcaa agaaccgcgc      600

ggcatcggcg gcattttcta tgactggctg gaaagcggcg attggaatgc cgactttgcc      660

tttacccaag atgtgggtcg tacctttgcc gccatctatc cggaactggt tcgccgtaac      720

tttgaaaccc cgtggcagcc ggcagatcgt gaagaacagc tggtgcgtcg cggccgctac      780

gttgagttca atttactgta cgatcgtggc accatctttg gtctgaagac cggtggcaac      840

gtggaaagca ttttaagcag catgccgccg gaggtgaagt ggccgtaa                   888


<210>  21
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  21
atggccccgc cggttaccga tctgggtgaa ctgcgtcgcc gtccgggtga tatgaaaacc       60

aaaatggaac tgctgattct ggaaacccaa gctcaagttt gtcaagcttt agcacaagtg      120

gacggtggcg ccaattttag cgtggaccgc tgggaacgca aagaaggtgg cggcggtatt      180

agctgtgtgc tgcaagatgg ctgcgtgttc gaaaaagccg gtgtgagcat tagcgtggtg      240

catggcaatc tgagcgaaga agccgcaaag cagatgcgta gccgcggtaa ggtgctgaaa      300

accaaggacg gcaaactgcc gttctgcgca atgggcgtga gtagcgtgat ccaccctaaa      360

aatccgcacg ccccgaccat ccattttaac tatcgctact tcgaagtgga ggaagccgat      420

ggcaataagc agtggtggtt tggcggtggc tgcgatctga ccccgaccta tctgaaccaa      480

gaagatgccg tgcattttca tcgcacttta aaagaagctt gtgatcagca tggccccgat      540

ttatacccga agttcaagaa gtggtgtgac gactacttct ttatcgccca tcgcggtgaa      600

cgtcgtggca tcggtggcat ctttttcgac gatctggata gcccgagcaa agaagaagtt      660

tttcgcttcg ttcagagctg cgcccgcgcc gttgttccta gctacatccc gctggtgaag      720

aagcattgcg atgacagctt caccccgcaa gaaaaactgt ggcagcagct gcgccgtggt      780

cgctacgtgg agtttaattt actgtatgat cgcggcacca aatttggttt attcaccccg      840

ggtagccgta tcgaaagcat tttaatgagt ctgccgctga ccgcccgctg ggaatacatg      900

cacagtccga gcgaaaacag caaagaagct gagattctgg aggtgttacg ccatccgcgt      960

gattgggttc gctaa                                                       975


<210>  22
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  22
atggacaccc aagctgttcg cgcctattta ctggatctgc aagatcgcat taccaccgcc       60

gcaagcgctt tagacggtgg tacctttgtg accgacgctt gggaaaaacc tccgacagaa      120

cgtctgcgtg gcagcggtcg cacccgtatt ctggaaggtg gtgcactgct ggaacgcggt      180

ggcgtgggtt ttagccatgt gatgggtgat actttaccgc cgagcgcaac cgcaaatcgt      240

cccgaactgg ccggtcgcgg ttttgaggca atgggcgtgt ctttagtgtt tcatccgcgt      300

aatccgtacg tgccgaccgt tcatatgaat gtgcgctgct tcgttgccgt gcgtagcgat      360

gcagcaccgg tgtggtggtt tggcggcggt atggatctga ccccgtacta tggcttcacc      420

gaagatgcca gccatttcca tcgtacatgc caaggtgctt tagcaccgta tggtgacgaa      480

ctgtatccgc gctttaagca gtggtgtgac gactattttt atctgaaaca tcgcaaagag      540

gcccgtggca ttggtggcat cttcttcgac gactttgccg aactgggttt cgagcgcagc      600

tttgaaatga tgcgcagcgt gggcgatgcc tttctgccgg cttggttacc gattgcagaa      660

cagcgtcatg ccaccgcata cggcgaacgt gaacgtgcct ttcaagctta tcgccgtggt      720

cgctacgtgg agttcaatct ggtgttcgat cgtggcactt tatttggttt acaaagcggt      780

ggtcgtgccg agagcattct gatgagcatg ccgccggttg ccaattggcg ttatgactgg      840

cagccggaac ccggtagccc ggaagccgca ctgtacaccg attttctgcc ggcacgcgac      900

tgggtgtaa                                                              909


<210>  23
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  23
atgaaacccg acgcacacca ggttaaacag tttctgctca accttcagga tacgatttgt       60

cagcagctga ccgccgtcga tggcgcagaa tttgtcgaag atagttggca gcgcgaagct      120

ggcggcggcg ggcgtagtcg ggtgttgcgt aatggtggtg ttttcgaaca ggcaggcgtc      180

aacttttcgc atgtccacgg tgaggcgatg cctgcttccg ccaccgctca tcgcccggaa      240

cttgccgggc gcagtttcga ggcgatgggc gtttcactgg tagtgcatcc gcataacccg      300

tatgttccca ccagccacgc gaatgtgcgg ttttttattg ccgaaaaacc gggtgccgat      360

cccgtctggt ggtttggcgg tggcttcgac ttaaccccat tctatggttt tgaagaagat      420

gctattcact ggcatcgcac cgcccgtgac ctgtgcctgc catttggcga agacgtttat      480

ccccgttaca aaaagtggtg cgacgaatac ttctacctca aacatcgcaa cgaacagcgc      540

ggtattggcg ggctgttctt tgatgacctg aacacgccag atttcgaccg ctgttttgcc      600

tttatgcagg cggtaggcaa aggctacacc gacgcttatt taccaattgt cgagcgacgg      660

aaagcgatgg cctacggcga gcgcgagcgc aatttccagt tatatcgtcg cggtcgttat      720

gtcgagttca atctggtctg ggatcgcggc acgctgtttg gcctgcaaac tggcgggcgc      780

accgagtcta tcctgatgtc aatgccgcca ctggtacgct gggaatatga ttatcagcca      840

aaagatggca gcccagaagc ggcgttaagt gagtttatta aggtcaggga ttgggtgtaa      900


<210>  24
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  24
atgaccgacc gtatcgccgc tgtcaaaacc tacctgctcg acctgcaaga ccgcatctgc       60

gccgccctcg aggcggagga cggcaaggcc cgcttcgccg aggacgcctg ggagcgtccg      120

gccggtggcg gcggacggac gcgggtaatc ggcgacggcg cattgatcga gaagggcggg      180

gtgaattttt cccacgtctt cggcgatagc ctgccgccct cggccagcgc ccatcggccg      240

gaactggccg ggcgcggttt ccaggcgctc ggcgtgtcgc tggtgatcca tccggaaaac      300

ccccacgtgc cgacgtccca tgccaacgtg cgtttcttct gcgccgagaa ggaaggcgag      360

gagccggtct ggtggttcgg cggcggcttc gatctgaccc cctactacgc ccacgaggaa      420

gactgcgtgc attggcaccg ggtcgctcgc gacgcctgcg cgccgttcgg cgcggacgtc      480

tacccgcgct acaaggaatg gtgcgaccgc tacttccacc tcaagcaccg caacgagccg      540

cgcggcatcg gcggcctgtt cttcgacgac ctcaaccagt gggacttcga cacctgcttc      600

gccttcatcc gcgccatcgg cgatgcctat atcgacgcct acctgccgat cgtccagcgc      660

cgcaagcaca cgccgttcga tgaacggcag cgagagttcc aggcctatcg tcgcggtcgc      720

tatgtggagt tcaacctggt cttcgatcgt ggcaccctgt tcggcctgca gtccggcggc      780

cgtaccgaat cgatcctgat gtcgttgccg ccgcaggtgc gctggggcta tgactggaaa      840

cccgagccgg gcagcgagga agcgcgcctg accgagtatt tcctcgccga ccgcgattgg      900

ctcgccggcc agccctga                                                    918


<210>  25
<211>  2007
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  25
atgaaacact actccataca acctgccaac ctcgaattta atgctgaggg tacacctgtt       60

tcccgagatt ttgacgatgt ctatttttcc aacgataacg ggctggaaga gacgcgttat      120

gtttttctgg gaggcaacca attagaggta cgctttcctg agcatccaca tcctctgttt      180

gtggtagcag agagcggctt cggcaccgga ttaaacttcc tgacgctatg gcaggcattt      240

gatcagtttc gcgaagcgca tccgcaagcg caattacaac gcttacattt cattagtttt      300

gagaaatttc ccctcacccg tgcggattta gccttagcgc atcaacactg gccggaactg      360

gctccgtggg cagaacaact tcaggcgcag tggccaatgc ccttgcccgg ttgccatcgt      420

ttattgctcg atgaaggccg cgtgacgctg gatttatggt ttggcgatat taacgaactg      480

accagccaac tggacgattc gctaaatcaa aaagtagatg cctggtttct ggacggcttt      540

gcgccagcga aaaacccgga tatgtggacg caaaatctgt ttaacgccat ggcaaggttg      600

gcgcgtccgg gcggcacgct ggcgacattt acgtctgccg gttttgtccg ccgcggtttg      660

caggacgccg gattcacgat gcaaaaacgt aagggctttg ggcgcaaacg ggaaatgctt      720

tgcggggtga tggaacagac attaccgctc ccctgctccg cgccgtggtt taaccgcacg      780

ggcagcagca aacgggaagc ggcgattatc ggcggtggta ttgccagcgc gttgttgtcg      840

ctggcgctat tacggcgcgg ctggcaggta acgctttatt gcgcggatga ggcccccgca      900

ctgggtgctt ccggcaatcg ccagggggcg ctgtatccgt tattaagcaa acacgatgag      960

gcgctaaacc gctttttctc taatgcgttt acttttgctc gtcggtttta cgaccaatta     1020

cccgttaaat ttgatcatga ctggtgcggc gtcacgcagt taggctggga tgagaaaagc     1080

cagcataaaa tcgcacagat gttgtcaatg gatttacccg cagaactggc tgtagccgtt     1140

gaggcaaatg cggttgaaca aattacgggc gttgcgacaa attgcagcgg cattacttat     1200

ccgcaaggtg gttggctgtg cccagcagaa ctgacccgta atgtgctgga actggcgcaa     1260

cagcagggtt tgcagattta ttatcaatat cagttacaga atttatcccg taaggatgac     1320

tgttggttgt tgaattttgc aggagatcag caagcaacac acagcgtagt ggtactggcg     1380

aacgggcatc aaatcagccg attcagccaa acgtcgactc tcccggtgta ttcggttgcc     1440

gggcaggtca gccatattcc gacaacgccg gaattggcag agctgaagca ggtgctgtgc     1500

tatgacggtt atctcacgcc acaaaatccg gcgaatcaac atcattgtat tggtgccagt     1560

tatcatcgcg gcagcgaaga tacggcgtac agtgaggacg atcagcagca gaatcgccag     1620

cggttgattg attgtttccc gcaggcacag tgggcaaaag aggttgatgt cagtgataaa     1680

gaggcgcgct gcggtgtgcg ttgtgccacc cgcgatcatc tgccaatggt aggcaatgtt     1740

cccgattatg aggcaacact cgtggaatat gcgtcgttgg cggagcagaa agatgaggcg     1800

gtaagcgcgc cggtttttga cgatctcttt atgtttgcgg ctttaggttc tcgcggtttg     1860

tgttctgccc cgctgtgtgc cgagattctg gcggcgcaga tgagcgacga accgattccg     1920

atggatgcca gtacgctggc ggcgttaaac ccgaatcggt tatgggtgcg gaaattgttg     1980

aagggtaaag cggttaaggc ggggtaa                                         2007


<210>  26
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  26
ccctgctccg cgccgtggtt taaccgcacg ggcagcagca aacgggaagc ggcgattatc       60

ggcggtggta ttgccagcgc gttgttgtcg ctggcgctat tacggcgcgg ctggcaggta      120

acgctttatt gcgcggatga ggcccccgca ctgggtgctt ccggcaatcg ccagggggcg      180

ctgtatccgt tattaagcaa acacgatgag gcgctaaacc gctttttctc taatgcgttt      240

acttttgctc gtcggtttta cgaccaatta cccgttaaat ttgatcatga ctggtgcggc      300

gtcacgcagt taggctggga tgagaaaagc cagcataaaa tcgcacagat gttgtcaatg      360

gatttacccg cagaactggc tgtagccgtt gaggcaaatg cggttgaaca aattacgggc      420

gttgcgacaa attgcagcgg cattacttat ccgcaaggtg gttggctgtg cccagcagaa      480

ctgacccgta atgtgctgga actggcgcaa cagcagggtt tgcagattta ttatcaatat      540

cagttacaga atttatcccg taaggatgac tgttggttgt tgaattttgc aggagatcag      600

caagcaacac acagcgtagt ggtactggcg aacgggcatc aaatcagccg attcagccaa      660

acgtcgactc tcccggtgta ttcggttgcc gggcaggtca gccatattcc gacaacgccg      720

gaattggcag agctgaagca ggtgctgtgc tatgacggtt atctcacgcc acaaaatccg      780

gcgaatcaac atcattgtat tggtgccagt tatcatcgcg gcagcgaaga tacggcgtac      840

agtgaggacg atcagcagca gaatcgccag cggttgattg attgtttccc gcaggcacag      900

tgggcaaaag aggttgatgt cagtgataaa gaggcgcgct gcggtgtgcg ttgtgccacc      960

cgcgatcatc tgccaatggt aggcaatgtt cccgattatg aggcaacact cgtggaatat     1020

gcgtcgttgg cggagcagaa agatgaggcg gtaagcgcgc cggtttttga cgatctcttt     1080

atgtttgcgg ctttaggttc tcgcggtttg tgttctgccc cgctgtgtgc cgagattctg     1140

gcggcgcaga tgagcgacga accgattccg atggatgcca gtacgctggc ggcgttaaac     1200

ccgaatcggt tatgggtgcg gaaattgttg aagggtaaag cggttaaggc ggggtaa        1257


