                               SEQUENCE LISTING

<110> UNIVERSITY OF MASSACHUSETTS
 
<120> AIM2 INHIBITORS AND USES THEREOF

<130> 07917-0415WO1

<140> PCT/US2020/028535
<141> 2020-04-16

<150> 62/972,831
<151> 2020-02-11

<150> 62/835,861
<151> 2019-04-18

<160> 48    

<170> PatentIn version 3.5

<210> 1
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
gaaguugaau uauaa                                                        15


<210> 2
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
uuauaauuca acuucugaaa                                                   20


<210> 3
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
guugaauuau augca                                                        15


<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ugcauauaau ucaacuucug                                                   20


<210> 5
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
aaacagaugg uggca                                                        15


<210> 6
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ugccaccauc uguuucuguu                                                   20


<210> 7
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
uuuguaaaag uuuua                                                        15


<210> 8
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
uaaaacuuuu acaaagaaga                                                   20


<210> 9
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gaacaauugu gaaua                                                        15


<210> 10
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
uauucacaau uguuccaagg                                                   20


<210> 11
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
acaauuguga augga                                                        15


<210> 12
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
uccauucaca auuguuccaa                                                   20


<210> 13
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gucuaagguu ugaga                                                        15


<210> 14
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
ucucaaaccu uagacaaagc                                                   20


<210> 15
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
ugauaaauaa auaaa                                                        15


<210> 16
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
uuuauuuauu uaucaacaau                                                   20


<210> 17
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gcugaaagcu auaaa                                                        15


<210> 18
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
uuuauagcuu ucagcaccgu                                                   20


<210> 19
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
guaaaaguuu uaaaa                                                        15


<210> 20
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
uuuuaaaacu uuuacaaaga                                                   20


<210> 21
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
uaugcauauu gcaaa                                                        15


<210> 22
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
uuugcaauau gcauauaauu                                                   20


<210> 23
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
uagaaaagga caaaa                                                        15


<210> 24
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
uuuuguccuu uucuaaguaa                                                   20


<210> 25
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
ugacaaauac gauua                                                        15


<210> 26
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
uaaucguauu ugucaaucau                                                   20


<210> 27
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
guugaauuau augca                                                        15


<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
ugcauauaau ucaacuucug                                                   20


<210> 29
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
uuuguaaaag uuuua                                                        15


<210> 30
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
uaaaacuuuu acaaagaaga                                                   20


<210> 31
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gcugaaagcu auaaa                                                        15


<210> 32
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
uuuauagcuu ucagcaccgu                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ataagcagct ccagctccaa                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 34
ctgtctgctg gtggagttca                                                   20


<210> 35
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 35
atggctaggc tctgtgcttt cct                                               23


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 36
agggctctcc agacttctgc tctg                                              24


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 37
aggggagtga tggagagagg                                                   20


<210> 38
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 38
tgaaagcgtt tagccaaaaa agg                                               23


<210> 39
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 39
atctccgttc ttcagtgtag caatg                                             25


<210> 40
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 40
acaaatccct caaagacctc aaacag                                            26


<210> 41
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 41
gttgaatcta accacgaagt cc                                                22


<210> 42
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 42
ctacaaggtc cagatttcaa ctg                                               23


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 43
ggctgtattc ccctccatcg                                                   20


<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 44
ccagttggta acaatgccat gt                                                22


<210> 45
<211> 343
<212> PRT
<213> Homo sapiens

<400> 45
Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Thr Gly Leu Asp Asn 
1               5                   10                  15      


Ile Thr Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          


Phe Asn Ile Ala Thr Gly Lys Leu His Thr Ala Asn Arg Ile Gln Val 
        35                  40                  45              


Ala Thr Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  


Thr Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  


Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Thr 
                85                  90                  95      


Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         


Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             


Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 


Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 


Ala Lys Lys Pro Phe Thr Phe Glu Thr Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     


Phe His Ala Thr Val Ala Thr Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         


Phe Asn Thr Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             


Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 


Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 


Asn Ile Ile Arg Lys Ala Gly Glu Thr Pro Lys Ile Asn Thr Leu Gln 
                245                 250                 255     


Thr Gln Pro Leu Gly Thr Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         


Val Thr Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Thr 
        275                 280                 285             


Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Thr Met Lys Cys 
    290                 295                 300                 


Lys Glu Gly Asp Lys Val Arg Leu Thr Phe Phe Thr Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Glu Lys Leu Gln Leu Thr Ser Gly Val His Ser Thr Ile Lys Val 
                325                 330                 335     


Ile Lys Ala Lys Lys Lys Thr 
            340             


<210> 46
<211> 1394
<212> DNA
<213> Homo sapiens

<400> 46
agaagtgtca gagtctttgt agctttgaaa gtcacctagg ttatttgggc atgctctcct       60

gagtcctctg ctagttaagc tctctgaaaa gaaggtggca gacccggttt gctgatcgcc      120

ccagggatca ggaggctgat cccaaagttg tcagatggag agtaaataca aggagatact      180

cttgctaaca ggcctggata acatcactga tgaggaactg gataggttta agttctttct      240

ttcagacgag tttaatattg ccacaggcaa actacatact gcaaacagaa tacaagtagc      300

taccttgatg attcaaaatg ctggggcggt gtctgcagtg atgaagacca ttcgtatttt      360

tcagaagttg aattatatgc ttttggcaaa acgtcttcag gaggagaagg agaaagttga      420

taagcaatac aaatcggtaa caaaaccaaa gccactaagt caagctgaaa tgagtcctgc      480

tgcatctgca gccatcagaa atgatgtcgc aaagcaacgt gctgcaccaa aagtctctcc      540

tcatgttaag cctgaacaga aacagatggt ggcccagcag gaatctatca gagaagggtt      600

tcagaagcgc tgtttgccag ttatggtact gaaagcaaag aagcccttca cgtttgagac      660

ccaagaaggc aagcaggaga tgtttcatgc tacagtggct acagaaaagg aattcttctt      720

tgtaaaagtt tttaatacac tgctgaaaga taaattcatt ccaaagagaa taattataat      780

agcaagatat tatcggcaca gtggtttctt agaggtaaat agcgcctcac gtgtgttaga      840

tgctgaatct gaccaaaagg ttaatgtccc gctgaacatt atcagaaaag ctggtgaaac      900

cccgaagatc aacacgcttc aaactcagcc ccttggaaca attgtgaatg gtttgtttgt      960

agtccagaag gtaacagaaa agaagaaaaa catattattt gacctaagtg acaacactgg     1020

gaaaatggaa gtactggggg ttagaaacga ggacacaatg aaatgtaagg aaggagataa     1080

ggttcgactt acattcttca cactgtcaaa aaatggagaa aaactacagc tgacatctgg     1140

agttcatagc accataaagg ttattaaggc caaaaaaaaa acatagagaa gtaaaaagga     1200

ccaattcaag ccaactggtc taagcagcat ttaattgaag aatatgtgat acagcctctt     1260

caatcagatt gtaagttacc tgaaagctgc agttcacagg ctcctctctc caccaaatta     1320

ggatagaata attgctggat aaacaaattc agaatatcaa cagatgatca caataaacat     1380

ctgtttctca ttca                                                       1394


<210> 47
<211> 354
<212> PRT
<213> Mus musculus

<400> 47
Met Glu Ser Glu Tyr Arg Glu Met Leu Leu Leu Thr Gly Leu Asp His 
1               5                   10                  15      


Ile Thr Glu Glu Glu Leu Lys Arg Phe Lys Tyr Phe Ala Leu Thr Glu 
            20                  25                  30          


Phe Gln Ile Ala Arg Ser Thr Leu Asp Val Ala Asp Arg Thr Glu Leu 
        35                  40                  45              


Ala Asp His Leu Ile Gln Ser Ala Gly Ala Ala Ser Ala Val Thr Lys 
    50                  55                  60                  


Ala Ile Asn Ile Phe Gln Lys Leu Asn Tyr Met His Ile Ala Asn Ala 
65                  70                  75                  80  


Leu Glu Glu Lys Lys Lys Glu Ala Glu Arg Lys Leu Met Thr Asn Thr 
                85                  90                  95      


Lys Lys Arg Gly Thr Gln Lys Val Glu Asn Arg Ser Gln Ala Glu Asn 
            100                 105                 110         


Cys Ser Ala Ala Ser Ala Thr Arg Ser Asp Asn Asp Phe Lys Glu Gln 
        115                 120                 125             


Ala Ala Thr Glu Val Cys Pro Gln Ala Lys Pro Gln Lys Lys Gln Met 
    130                 135                 140                 


Val Ala Glu Gln Glu Ala Ile Arg Glu Asp Leu Gln Lys Asp Pro Leu 
145                 150                 155                 160 


Val Val Thr Val Leu Lys Ala Ile Asn Pro Phe Glu Cys Glu Thr Gln 
                165                 170                 175     


Glu Gly Arg Gln Glu Ile Phe His Ala Thr Val Ala Thr Glu Thr Asp 
            180                 185                 190         


Phe Phe Phe Val Lys Val Leu Asn Ala Gln Phe Lys Asp Lys Phe Ile 
        195                 200                 205             


Pro Lys Arg Thr Ile Lys Ile Ser Asn Tyr Leu Trp His Ser Asn Phe 
    210                 215                 220                 


Met Glu Val Thr Ser Ser Ser Val Val Val Asp Val Glu Ser Asn His 
225                 230                 235                 240 


Glu Val Pro Asn Asn Val Val Lys Arg Ala Arg Glu Thr Pro Arg Ile 
                245                 250                 255     


Ser Lys Leu Lys Ile Gln Pro Cys Gly Thr Ile Val Asn Gly Leu Phe 
            260                 265                 270         


Lys Val Gln Lys Ile Thr Glu Glu Lys Asp Arg Val Leu Tyr Gly Ile 
        275                 280                 285             


His Asp Lys Thr Gly Thr Met Glu Val Leu Val Leu Gly Asn Pro Ser 
    290                 295                 300                 


Lys Thr Lys Cys Glu Glu Gly Asp Lys Ile Arg Leu Thr Phe Phe Glu 
305                 310                 315                 320 


Val Ser Lys Asn Gly Val Lys Ile Gln Leu Lys Ser Gly Pro Cys Ser 
                325                 330                 335     


Phe Phe Lys Val Ile Lys Ala Ala Lys Pro Lys Thr Asp Met Lys Ser 
            340                 345                 350         


Val Glu 
        


<210> 48
<211> 2541
<212> DNA
<213> Mus musculus

<400> 48
ttcctgtcct gtctgccgcc atgcttcctt aactagctgc taggtttttt ccttgtcgtg       60

atgaaatcca ccctcatgga cctacactac cgaactggac tgctggtata ttcatgaagt      120

gcttatgagt ggatcgagca gcccctatgg attcctgtga acagaactgc tgatttacta      180

acaacgcaga tggaagttgc ttcaaagaac aacttctgaa caggtattgt tgcccattct      240

gtgaataata caaaggcagt gggaacaaga cagtacagag gacttgattc aggagacttg      300

aggtctggcc gcatagtcat cctttagaag ctgggtggcg tcaggaagtt ttcctttttc      360

tcaatgtaaa gtgaagaaaa aaaatccagt gtttctcaac tgtactgcta ttcctattta      420

gctattgtat ctaggctgat cctgggactg tgagatggag agtgagtacc gggaaatgct      480

gttgttgacc ggcctggacc acatcacgga ggaagaactg aaacggttca agtactttgc      540

tttgactgag tttcagattg ccaggagcac actcgacgtg gcagatagga cagagttagc      600

tgaccacctg attcaaagtg caggtgcggc gtctgcagtg accaaggcca ttaatatttt      660

ccagaagttg aattatatgc atattgcaaa tgctcttgaa gagaaaaaga aagaagctga      720

acgtaaactc atgaccaata caaagaagag aggaacacag aaggtagaaa atagaagtca      780

agctgaaaac tgctctgctg cctctgccac ccgcagtgac aatgacttta aggaacaggc      840

tgctacagaa gtctgtcctc aagctaagcc tcagaagaaa cagatggtgg cagaacagga      900

agccatcaga gaagatttac agaaagatcc acttgttgtc acggtgctga aagctataaa      960

tccctttgag tgtgagactc aggaaggaag acaagagata tttcatgcaa cagtggccac     1020

ggagacagat tttttctttg taaaagtttt aaacgcacag tttaaagata aatttatccc     1080

aaagaggaca attaaaatat caaactacct ttggcacagt aacttcatgg aggtcaccag     1140

ttcctcagtt gtggttgatg ttgaatctaa ccacgaagtc ccaaataacg ttgttaagag     1200

agccagggaa actcccagga ttagtaaact gaagattcag ccatgtggaa caattgtgaa     1260

tgggctgttt aaagtccaga agataacaga ggaaaaagat agagtactgt atggtataca     1320

tgataaaaca gggacaatgg aggtgttggt gctgggaaac ccaagcaaaa caaagtgcga     1380

ggaaggagac aagattagac tcacgttctt tgaggtgtca aaaaatggag tgaaaattca     1440

gttgaaatct ggaccttgta gcttttttaa ggttattaag gctgcaaagc caaaaactga     1500

catgaaaagt gtggagtgaa gtcacctcat ttgaaaaacc ttttcctgaa gaatcctgat     1560

gctgctcctt gaactagact gaactacctg aggatagcat tttacaacct catcatcata     1620

ttgtattact tagaaaagga caaatactca aaaaacatct gaaaaatata tgtaaactta     1680

ttattaatta agttattaag actgcccaac ctggggatcc atcctatata caaccaccaa     1740

acccagacac tattgcatat gccagcaaga ttttgctgac aggatcctga tatagctctc     1800

tcttgtgagg ctctgccagt gactgacaag tacagaagca gatgctcaca gtcatctatt     1860

ggatggaaca cagggcccct aataaaggag ctagagaaag tacccaagca gcaagtggtc     1920

tgcaacgcta taggaggaac aacaacatga actaaccagt accccccaga actgtgtctc     1980

cagttgcata tgtagcagaa gatggcctgg ccggtcatca atgggaggag aggcccttgg     2040

tcttgcaaag atcatatgcc ccagtacagg ggaatgccag ggccaggcag caggagtgga     2100

tgtgggtggg ttggggagtg tgtgtggggg gtgttatagg ggactttcgg gatagcattt     2160

gaaatgtaaa tgaagaaaat atctaataaa attgttgctt tgtctaaggt ttgagatatc     2220

attcttctct acatagacac tgagggtata agtatggcgg gattgcagat gtgacagcag     2280

ggccttgtcg gagagacgcc tgtgggtgat agagaagatt ggtgatatat aattttttaa     2340

tttaaaaatt ttaaatttcc ttttggggag gaggttacag gtggaggagg gtgggtatga     2400

tagtactaag aaatcagtga tattggggta tgtgatgtga aattccctag cactcaataa     2460

aagaattatg tttttaaaaa gaaagattgt tgataaataa ataaatatga ttttactcat     2520

gattcagaaa gttagaaaaa a                                               2541


