                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  GENE THERAPIES FOR USHER SYNDROME (USH1B)

<130>  U0120.70120WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/836,414
<151>  2019-04-19

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  7483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
agtgctggct ggacagctgc tctgggcagg agagagaggg agagacaaga gacacacaca       60

gagagacggc gaggaaggga aagacccaga gggacgccta gaacgagact tggagccaga      120

cagaggaaga ggggacgtgt gtttgcagac tggctgggcc cgtgacccag cttcctgagt      180

cctccgtgca ggtggcagct gtaccaggct ggcaggtcac tgagagtggg cagctgggcc      240

ccagaactgt gcctggccca gtgggcagca ggagctcctg acttgggacc atggtgattc      300

ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc gacgtgccca      360

tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat gatgaagaca      420

atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac cccacgtcgg      480

tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc atcttgcgca      540

acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc atcctggtgg      600

ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc cagtatacca      660

acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac tgctacttca      720

acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct ggggccggga      780

agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg cagcactcgt      840

ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg aatgccaaga      900

ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac ttcaacaagc      960

ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca cgtgtctgtc     1020

gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag ggtatgagtg     1080

aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac ttggccatgg     1140

gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac atccgctccg     1200

ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag ctcctggctg     1260

ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac ctggatgcct     1320

gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag gtgaaccccc     1380

cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag acggtgtcca     1440

ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag gggatctacg     1500

ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag cctccctccc     1560

aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg tttgagaact     1620

ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac ctgcagcagt     1680

tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag agcattgact     1740

ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc aacaagccca     1800

tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca gacaccacca     1860

tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc cccaagaaca     1920

accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat gagacccaag     1980

gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg gtccactcct     2040

ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc gccgagacca     2100

ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg ctgatgcgca     2160

cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag ttcaagaagc     2220

ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga atgatggaga     2280

ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag tttgtggagc     2340

ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac ctccgcggga     2400

cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag ataggcaaaa     2460

ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg gacaaagcca     2520

tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac aggtctaact     2580

ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt cacaactgta     2640

ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg caccgctccc     2700

ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc caggcccgct     2760

gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg ctcaccgtgc     2820

aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg gctgagtatc     2880

tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt cggaaggaga     2940

tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc ctggcccagc     3000

tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg cggaagaagg     3060

agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca gacatggtgg     3120

acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag ggccaggcac     3180

ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag gacctggatg     3240

cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa tttgccaagt     3300

tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg ccactcaaac     3360

agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg gtctggatca     3420

ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc atgagtgatg     3480

gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag aagacgtaca     3540

agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag ggccagaaga     3600

agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc aagctcacag     3660

aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac agcatgctgg     3720

aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat ggcatcctgc     3780

ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc cacaacccct     3840

ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc tgtttcgccc     3900

cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg cccggctacg     3960

ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg acacagccgc     4020

ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg cccgtgacat     4080

tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc aaggagctct     4140

gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc ctctacattg     4200

ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg gacgccatct     4260

cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc ccctggaggc     4320

tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac aacgtggcca     4380

ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac aggtgtgaga     4440

aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat ggctctgaga     4500

tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc gagatcacgc     4560

ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag aaggggattt     4620

atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt tatgcccgct     4680

tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca ggccccagtc     4740

tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt gtggatgagc     4800

aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc agcagcaggg     4860

agtgccgtgt ctggctctca ctgggctgct ctgatcttgg ctgtgctgcg cctcactcag     4920

gctgggcagg actgaccccg gcggggccct gttctccgtg ttggtcctgc aggggagcga     4980

aaacgacggc ccccagcttc acgctggcca ccatcaaggg ggacgaatac accttcacct     5040

ccagcaatgc tgaggacatt cgtgacctgg tggtcacctt cctagagggg ctccggaaga     5100

gatctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag gagtcaggct     5160

tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc gagcaggtca     5220

tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg gacttcccca     5280

ccgacagtgt gtacgtcatg cccactgtca ccatgccacc gcgggagatt gtggccctgg     5340

tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg cgaacggcgg     5400

agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac tacttcaggc     5460

ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc aaggaccggc     5520

tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc ctgggcagtg     5580

aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac atgggcgact     5640

acccgtccaa gaggacacgc tccgtcaacg agctcaccga ccagatcttt gagggtcccc     5700

tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag ctgaccgaca     5760

accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc acgggccttt     5820

tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc cgaaagcact     5880

gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac gggtcccgga     5940

agtaccctcc gcacctggtg gaggtggagg ccatccagca caagaccacc cagattttcc     6000

acaaagtcta cttccctgat gacactgacg aggccttcga agtggagtcc agcaccaagg     6060

ccaaggactt ctgccagaac atcgccacca ggctgctcct caagtcctca gagggattca     6120

gcctctttgt caaaattgca gacaaggtcc tcagcgttcc tgagaatgac ttcttctttg     6180

actttgttcg acacttgaca gactggataa agaaagctcg gcccatcaag gacggaattg     6240

tgccctcact cacctaccag gtgttcttca tgaagaagct gtggaccacc acggtgccag     6300

ggaaggatcc catggccgat tccatcttcc actattacca ggagttgccc aagtatctcc     6360

gaggctacca caagtgcacg cgggaggagg tgctgcagct gggggcgctg atctacaggg     6420

tcaagttcga ggaggacaag tcctacttcc ccagcatccc caagctgctg cgggagctgg     6480

tgccccagga ccttatccgg caggtctcac ctgatgactg gaagcggtcc atcgtcgcct     6540

acttcaacaa gcacgcaggg aagtccaagg aggaggccaa gctggccttc ctgaagctca     6600

tcttcaagtg gcccaccttt ggctcagcct tcttcgaggt gaagcaaact acggagccaa     6660

acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc atcgatccca     6720

aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg agcagcggca     6780

acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg ctctgcgaga     6840

cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag atgctcacag     6900

ccatgagcaa acagcggggc tccaggagcg gcaagtgaac agtcacgggg aggtgctggt     6960

tccatgcctg ctctcgaggc agcagtgggt tcaggcccat cagctacccc tgcagctggg     7020

gaagacttat gccatcccgg cagcgaggct gggctggcca gccaccactg actataccaa     7080

ctgggcctct gatgttcttc cagtgaggca tctctctggg atgcagaact tccctccatc     7140

cacccctctg gcacctgggt tggtctaatc ctagtttgct gtggccttcc cggttgtgag     7200

agcctgtgat ccttagatgt gtctcctgtt tcagaccagc cccaccatgc aacttccttt     7260

gactttctgt gtaccactgg gatagaggaa tcaagaggac aatctagctc tccatacttt     7320

gaacaaccaa atgtgcattg aatactctga aaccgaaggg actggatctg caggtgggat     7380

gagggagaca gaccactttt ctatattgca gtgtgaatgc tgggcccctg ctcaagtcta     7440

ccctgatcac ctcagggcat aaagcatgtt tcattctctg gcc                       7483


<210>  2
<211>  2215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Ser Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Thr Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Leu Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Lys Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Gly  Ser Arg Ser Gly Lys  
    2210                 2215 


<210>  3
<211>  2913
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     1560

cacaactgta ggaagaacta ccggctgcag gccctgcacc gctcccggaa gctgcaccag     1620

cagtaccgcc tggcccgcca gcgcatcatc cagttccagg cccgctgccg cgcctatctg     1680

gtgcgcaagg ccttccgcca ccgcctctgg gctgtgctca ccgtgcaggc ctatgcccgg     1740

ggcatgatcg cccgcaggct gcaccaacgc ctcagggctg agtatctgtg gcgcctcgag     1800

gctgagaaaa tgcggctggc ggaggaagag aagcttcgga aggagatgag cgccaagaag     1860

gccaaggagg aggccgagcg caagcatcag gagcgcctgg cccagctggc tcgtgaggac     1920

gctgagcggg agctgaagga gaaggaggcc gctcggcgga agaaggagct cctggagcag     1980

atggaaaggg cccgccatga gcctgtcaat cactcagaca tggtggacaa gatgtttggc     2040

ttcctgggga cttcaggtgg cctgccaggc caggagggcc aggcacctag tggctttgag     2100

gacctggagc gagggcggag ggagatggtg gaggaggacc tggatgcagc cctgcccctg     2160

cctgacgagg atgaggagga ctacacccgg cggccactca aacagccact gctctaccat     2220

gacgacgagg gtgaccagct ggcagccctg gcggtctgga tcaccatcct ccgcttcatg     2280

ggggacctcc ctgagcccaa gtaccacaca gccatgagtg atggcagtga gaagatccct     2340

gtgatgacca agatttatga gaccctgggc aagaagacgt acaagaggga gctgcaggcc     2400

ctgcagggcg agggcgaggc ccagctcccc gagggccaga agaagagcag tgtgaggcac     2460

aagctggtgc atttgactct gaaaaagaag tccaagctca cagaggaggt gaccaagagg     2520

ctgcatgacg gggagtccac agtgcagggc aacagcatgc tggaggaccg gcccacctcc     2580

aacctggaga agctgcactt catcatcggc aatggcatcc tgcggccagc actccgggac     2640

gagatctact gccagatcag caagcagctg acccacaacc cctccaagag cagctatgcc     2700

cggggctgga ttctcgtgtc tctctgcgtg ggctgtttcg ccccctccga gaagtttgtc     2760

aagtacctgc ggaacttcat ccacgggggc ccgcccggct acgccccgta ctgtgaggag     2820

cgcctgagaa ggacctttgt caatgggaca cggacacagc cgcccagctg gctggagctg     2880

caggccacca agtccaagaa gccaatcatg ttg                                  2913


<210>  4
<211>  2787
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

ttgctcttct ccaggtttta tgaagcctac aaattctcag gccccagtct ccccaagaac     1560

gacgtcatcg tggccgtcaa ctggacgggt gtgtactttg tggatgagca ggagcaggta     1620

cttctggagc tgtccttccc agagatcatg gccgtgtcca gcagcaggga gtgccgtgtc     1680

tggctctcac tgggctgctc tgatcttggc tgtgctgcgc ctcactcagg ctgggcagga     1740

ctgaccccgg cggggccctg ttctccgtgt tggtcctgca ggggagcgaa aacgacggcc     1800

cccagcttca cgctggccac catcaagggg gacgaataca ccttcacctc cagcaatgct     1860

gaggacattc gtgacctggt ggtcaccttc ctagaggggc tccggaagag atctaagtat     1920

gttgtggccc tgcaggataa ccccaacccc gcaggcgagg agtcaggctt cctcagcttt     1980

gccaagggag acctcatcat cctggaccat gacacgggcg agcaggtcat gaactcgggc     2040

tgggccaacg gcatcaatga gaggaccaag cagcgtgggg acttccccac cgacagtgtg     2100

tacgtcatgc ccactgtcac catgccaccg cgggagattg tggccctggt caccatgact     2160

cccgatcaga ggcaggacgt tgtccggctc ttgcagctgc gaacggcgga gcccgaggtg     2220

cgtgccaagc cctacacgct ggaggagttt tcctatgact acttcaggcc cccacccaag     2280

cacacgctga gccgtgtcat ggtgtccaag gcccgaggca aggaccggct gtggagccac     2340

acgcgggaac cgctcaagca ggcgctgctc aagaagctcc tgggcagtga ggagctctcg     2400

caggaggcct gcctggcctt cattgctgtg ctcaagtaca tgggcgacta cccgtccaag     2460

aggacacgct ccgtcaacga gctcaccgac cagatctttg agggtcccct gaaagccgag     2520

cccctgaagg acgaggcata tgtgcagatc ctgaagcagc tgaccgacaa ccacatcagg     2580

tacagcgagg agcggggttg ggagctgctc tggctgtgca cgggcctttt cccacccagc     2640

aacatcctcc tgccccacgt gcagcgcttc ctgcagtccc gaaagcactg cccactcgcc     2700

atcgactgcc tgcaacggct ccagaaagcc ctgagaaacg ggtcccggaa gtaccctccg     2760

cacctggtgg aggtggaggc catccag                                         2787


<210>  5
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
cggctgcagg ccctgcaccg ctcccggaag ctgcaccagc agtaccgcct ggcccgccag       60

cgcatcatcc agttccaggc ccgctgccgc gcctatctgg tgcgcaaggc cttccgccac      120

cgcctctggg ctgtgctcac cgtgcaggcc tatgcccggg gcatgatcgc ccgcaggctg      180

caccaacgcc tcagggctga gtatctgtgg cgcctcgagg ctgagaaaat gcggctggcg      240

gaggaagaga agcttcggaa ggagatgagc gccaagaagg ccaaggagga ggccgagcgc      300

aagcatcagg agcgcctggc ccagctggct cgtgaggacg ctgagcggga gctgaaggag      360

aaggaggccg ctcggcggaa gaaggagctc ctggagcaga tggaaagggc ccgccatgag      420

cctgtcaatc actcagacat ggtggacaag atgtttggct tcctggggac ttcaggtggc      480

ctgccaggcc aggagggcca ggcacctagt ggctttgagg acctggagcg agggcggagg      540

gagatggtgg aggaggacct ggatgcagcc ctgcccctgc ctgacgagga tgaggaggac      600

ttgctcttct ccaggtttta tgaagcctac aaattctcag gccccagtct ccccaagaac      660

gacgtcatcg tggccgtcaa ctggacgggt gtgtactttg tggatgagca ggagcaggta      720

cttctggagc tgtccttccc agagatcatg gccgtgtcca gcagcaggga gtgccgtgtc      780

tggctctcac tgggctgctc tgatcttggc tgtgctgcgc ctcactcagg ctgggcagga      840

ctgaccccgg cggggccctg ttctccgtgt tggtcctgca ggggagcgaa aacgacggcc      900

cccagcttca cgctggccac catcaagggg gacgaataca ccttcacctc cagcaatgct      960

gaggacattc gtgacctggt ggtcaccttc ctagaggggc tccggaagag atctaagtat     1020

gttgtggccc tgcaggataa ccccaacccc gcaggcgagg agtcaggctt cctcagcttt     1080

gccaagggag acctcatcat cctggaccat gacacgggcg agcaggtcat gaactcgggc     1140

tgggccaacg gcatcaatga gaggaccaag cagcgtgggg acttccccac cgacagtgtg     1200

tacgtcatgc ccactgtcac catgccaccg cgggagattg tggccctggt caccatgact     1260

cccgatcaga ggcaggacgt tgtccggctc ttgcagctgc gaacggcgga gcccgaggtg     1320

cgtgccaagc cctacacgct ggaggagttt tcctatgact acttcaggcc cccacccaag     1380

cacacgctga gccgtgtcat ggtgtccaag gcccgaggca aggaccggct gtggagccac     1440

acgcgggaac cgctcaagca ggcgctgctc aagaagctcc tgggcagtga ggagctctcg     1500

caggaggcct gcctggcctt cattgctgtg ctcaagtaca tgggcgacta cccgtccaag     1560

aggacacgct ccgtcaacga gctcaccgac cagatctttg agggtcccct gaaagccgag     1620

cccctgaagg acgaggcata tgtgcagatc ctgaagcagc tgaccgacaa ccacatcagg     1680

tacagcgagg agcggggttg ggagctgctc tggctgtgca cgggcctttt cccacccagc     1740

aacatcctcc tgccccacgt gcagcgcttc ctgcagtccc gaaagcactg cccactcgcc     1800

atcgactgcc tgcaacggct ccagaaagcc ctgagaaacg ggtcccggaa gtaccctccg     1860

cacctggtgg aggtggaggc catccag                                         1887


<210>  6
<211>  3474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaagttg ctcttctcca ggttttatga agcctacaaa     2220

ttctcaggcc ccagtctccc caagaacgac gtcatcgtgg ccgtcaactg gacgggtgtg     2280

tactttgtgg atgagcagga gcaggtactt ctggagctgt ccttcccaga gatcatggcc     2340

gtgtccagca gcagggagtg ccgtgtctgg ctctcactgg gctgctctga tcttggctgt     2400

gctgcgcctc actcaggctg ggcaggactg accccggcgg ggccctgttc tccgtgttgg     2460

tcctgcaggg gagcgaaaac gacggccccc agcttcacgc tggccaccat caagggggac     2520

gaatacacct tcacctccag caatgctgag gacattcgtg acctggtggt caccttccta     2580

gaggggctcc ggaagagatc taagtatgtt gtggccctgc aggataaccc caaccccgca     2640

ggcgaggagt caggcttcct cagctttgcc aagggagacc tcatcatcct ggaccatgac     2700

acgggcgagc aggtcatgaa ctcgggctgg gccaacggca tcaatgagag gaccaagcag     2760

cgtggggact tccccaccga cagtgtgtac gtcatgccca ctgtcaccat gccaccgcgg     2820

gagattgtgg ccctggtcac catgactccc gatcagaggc aggacgttgt ccggctcttg     2880

cagctgcgaa cggcggagcc cgaggtgcgt gccaagccct acacgctgga ggagttttcc     2940

tatgactact tcaggccccc acccaagcac acgctgagcc gtgtcatggt gtccaaggcc     3000

cgaggcaagg accggctgtg gagccacacg cgggaaccgc tcaagcaggc gctgctcaag     3060

aagctcctgg gcagtgagga gctctcgcag gaggcctgcc tggccttcat tgctgtgctc     3120

aagtacatgg gcgactaccc gtccaagagg acacgctccg tcaacgagct caccgaccag     3180

atctttgagg gtcccctgaa agccgagccc ctgaaggacg aggcatatgt gcagatcctg     3240

aagcagctga ccgacaacca catcaggtac agcgaggagc ggggttggga gctgctctgg     3300

ctgtgcacgg gccttttccc acccagcaac atcctcctgc cccacgtgca gcgcttcctg     3360

cagtcccgaa agcactgccc actcgccatc gactgcctgc aacggctcca gaaagccctg     3420

agaaacgggt cccggaagta ccctccgcac ctggtggagg tggaggccat ccag           3474


<210>  7
<211>  3708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

cggctgcagg ccctgcaccg ctcccggaag ctgcaccagc agtaccgcct ggcccgccag     1560

cgcatcatcc agttccaggc ccgctgccgc gcctatctgg tgcgcaaggc cttccgccac     1620

cgcctctggg ctgtgctcac cgtgcaggcc tatgcccggg gcatgatcgc ccgcaggctg     1680

caccaacgcc tcagggctga gtatctgtgg cgcctcgagg ctgagaaaat gcggctggcg     1740

gaggaagaga agcttcggaa ggagatgagc gccaagaagg ccaaggagga ggccgagcgc     1800

aagcatcagg agcgcctggc ccagctggct cgtgaggacg ctgagcggga gctgaaggag     1860

aaggaggccg ctcggcggaa gaaggagctc ctggagcaga tggaaagggc ccgccatgag     1920

cctgtcaatc actcagacat ggtggacaag atgtttggct tcctggggac ttcaggtggc     1980

ctgccaggcc aggagggcca ggcacctagt ggctttgagg acctggagcg agggcggagg     2040

gagatggtgg aggaggacct ggatgcagcc ctgcccctgc ctgacgagga tgaggaggac     2100

tacacccggc ggccactcaa acagccactg ctctaccatg acgacgaggg tgaccagctg     2160

gcagccctgg cggtctggat caccatcctc cgcttcatgg gggacctccc tgagcccaag     2220

taccacacag ccatgagtga tggcagtgag aagatccctg tgatgaccaa gatttatgag     2280

accctgggca agaagacgta caagagggag ctgcaggccc tgcagggcga gggcgaggcc     2340

cagctccccg agggccagaa gaagagcagt gtgaggcaca agctggtgca tttgactctg     2400

aaaaagaagt ccaagctcac agaggaggtg accaagaggc tgcatgacgg ggagtccaca     2460

gtgcagggca acagcatgct ggaggaccgg cccacctcca acctggagaa gctgcacttc     2520

atcatcggca atggcatcct gcggccagca ctccgggacg agatctactg ccagatcagc     2580

aagcagctga cccacaaccc ctccaagagc agctatgccc ggggctggat tctcgtgtct     2640

ctctgcgtgg gctgtttcgc cccctccgag aagtttgtca agtacctgcg gaacttcatc     2700

cacgggggcc cgcccggcta cgccccgtac tgtgaggagc gcctgagaag gacctttgtc     2760

aatgggacac ggacacagcc gcccagctgg ctggagctgc aggccaccaa gtccaagaag     2820

ccaatcatgt tgtctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag     2880

gagtcaggct tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc     2940

gagcaggtca tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg     3000

gacttcccca ccgacagtgt gtacgtcatg cccactgtca ccatgccacc gcgggagatt     3060

gtggccctgg tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg     3120

cgaacggcgg agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac     3180

tacttcaggc ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc     3240

aaggaccggc tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc     3300

ctgggcagtg aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac     3360

atgggcgact acccgtccaa gaggacacgc tccgtcaacg agctcaccga ccagatcttt     3420

gagggtcccc tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag     3480

ctgaccgaca accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc     3540

acgggccttt tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc     3600

cgaaagcact gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac     3660

gggtcccgga agtaccctcc gcacctggtg gaggtggagg ccatccag                  3708


<210>  8
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
cggctgcagg ccctgcaccg ctcccggaag ctgcaccagc agtaccgcct ggcccgccag       60

cgcatcatcc agttccaggc ccgctgccgc gcctatctgg tgcgcaaggc cttccgccac      120

cgcctctggg ctgtgctcac cgtgcaggcc tatgcccggg gcatgatcgc ccgcaggctg      180

caccaacgcc tcagggctga gtatctgtgg cgcctcgagg ctgagaaaat gcggctggcg      240

gaggaagaga agcttcggaa ggagatgagc gccaagaagg ccaaggagga ggccgagcgc      300

aagcatcagg agcgcctggc ccagctggct cgtgaggacg ctgagcggga gctgaaggag      360

aaggaggccg ctcggcggaa gaaggagctc ctggagcaga tggaaagggc ccgccatgag      420

cctgtcaatc actcagacat ggtggacaag atgtttggct tcctggggac ttcaggtggc      480

ctgccaggcc aggagggcca ggcacctagt ggctttgagg acctggagcg agggcggagg      540

gagatggtgg aggaggacct ggatgcagcc ctgcccctgc ctgacgagga tgaggaggac      600

ttgctcttct ccaggtttta tgaagcctac aaattctcag gccccagtct ccccaagaac      660

gacgtcatcg tggccgtcaa ctggacgggt gtgtactttg tggatgagca ggagcaggta      720

cttctggagc tgtccttccc agagatcatg gccgtgtcca gcagcaggga gtgccgtgtc      780

tggctctcac tgggctgctc tgatcttggc tgtgctgcgc ctcactcagg ctgggcagga      840

ctgaccccgg cggggccctg ttctccgtgt tggtcctgca ggggagcgaa aacgacggcc      900

cccagcttca cgctggccac catcaagggg gacgaataca ccttcacctc cagcaatgct      960

gaggacattc gtgacctggt ggtcaccttc ctagaggggc tccggaagag atctaagtat     1020

gttgtggccc tgcaggataa ccccaacccc gcaggcgagg agtcaggctt cctcagcttt     1080

gccaagggag acctcatcat cctggaccat gacacgggcg agcaggtcat gaactcgggc     1140

tgggccaacg gcatcaatga gaggaccaag cagcgtgggg acttccccac cgacagtgtg     1200

tacgtcatgc ccactgtcac catgccaccg cgggagattg tggccctggt caccatgact     1260

cccgatcaga ggcaggacgt tgtccggctc ttgcagctgc gaacggcgga gcccgaggtg     1320

cgtgccaagc cctacacgct ggaggagttt tcctatgact acttcaggcc cccacccaag     1380

cacacgctga gccgtgtcat ggtgtccaag gcccgaggca aggaccggct gtggagccac     1440

acgcgggaac cgctcaagca ggcgctgctc aagaagctcc tgggcagtga ggagctctcg     1500

caggaggcct gcctggcctt cattgctgtg ctcaagtaca tgggcgacta cccgtccaag     1560

aggacacgct ccgtcaacga gctcaccgac cagatctttg agggtcccct gaaagccgag     1620

cccctgaagg acgaggcata tgtgcagatc ctgaagcagc tgaccgacaa ccacatcagg     1680

tacagcgagg agcggggttg ggagctgctc tggctgtgca cgggcctttt cccacccagc     1740

aacatcctcc tgccccacgt gcagcgcttc ctgcagtccc gaaagcactg cccactcgcc     1800

atcgactgcc tgcaacggct ccagaaagcc ctgagaaacg ggtcccggaa gtaccctccg     1860

cacctggtgg aggtggaggc catccag                                         1887


<210>  9
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
ttgctcttct ccaggtttta tgaagcctac aaattctcag gccccagtct ccccaagaac       60

gacgtcatcg tggccgtcaa ctggacgggt gtgtactttg tggatgagca ggagcaggta      120

cttctggagc tgtccttccc agagatcatg gccgtgtcca gcagcaggga gtgccgtgtc      180

tggctctcac tgggctgctc tgatcttggc tgtgctgcgc ctcactcagg ctgggcagga      240

ctgaccccgg cggggccctg ttctccgtgt tggtcctgca ggggagcgaa aacgacggcc      300

cccagcttca cgctggccac catcaagggg gacgaataca ccttcacctc cagcaatgct      360

gaggacattc gtgacctggt ggtcaccttc ctagaggggc tccggaagag atctaagtat      420

gttgtggccc tgcaggataa ccccaacccc gcaggcgagg agtcaggctt cctcagcttt      480

gccaagggag acctcatcat cctggaccat gacacgggcg agcaggtcat gaactcgggc      540

tgggccaacg gcatcaatga gaggaccaag cagcgtgggg acttccccac cgacagtgtg      600

tacgtcatgc ccactgtcac catgccaccg cgggagattg tggccctggt caccatgact      660

cccgatcaga ggcaggacgt tgtccggctc ttgcagctgc gaacggcgga gcccgaggtg      720

cgtgccaagc cctacacgct ggaggagttt tcctatgact acttcaggcc cccacccaag      780

cacacgctga gccgtgtcat ggtgtccaag gcccgaggca aggaccggct gtggagccac      840

acgcgggaac cgctcaagca ggcgctgctc aagaagctcc tgggcagtga ggagctctcg      900

caggaggcct gcctggcctt cattgctgtg ctcaagtaca tgggcgacta cccgtccaag      960

aggacacgct ccgtcaacga gctcaccgac cagatctttg agggtcccct gaaagccgag     1020

cccctgaagg acgaggcata tgtgcagatc ctgaagcagc tgaccgacaa ccacatcagg     1080

tacagcgagg agcggggttg ggagctgctc tggctgtgca cgggcctttt cccacccagc     1140

aacatcctcc tgccccacgt gcagcgcttc ctgcagtccc gaaagcactg cccactcgcc     1200

atcgactgcc tgcaacggct ccagaaagcc ctgagaaacg ggtcccggaa gtaccctccg     1260

cacctggtgg aggtggaggc catccag                                         1287


<210>  10
<211>  2517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt       60

cacaactgta ggaagaacta ccggctgcag gccctgcacc gctcccggaa gctgcaccag      120

cagtaccgcc tggcccgcca gcgcatcatc cagttccagg cccgctgccg cgcctatctg      180

gtgcgcaagg ccttccgcca ccgcctctgg gctgtgctca ccgtgcaggc ctatgcccgg      240

ggcatgatcg cccgcaggct gcaccaacgc ctcagggctg agtatctgtg gcgcctcgag      300

gctgagaaaa tgcggctggc ggaggaagag aagcttcgga aggagatgag cgccaagaag      360

gccaaggagg aggccgagcg caagcatcag gagcgcctgg cccagctggc tcgtgaggac      420

gctgagcggg agctgaagga gaaggaggcc gctcggcgga agaaggagct cctggagcag      480

atggaaaggg cccgccatga gcctgtcaat cactcagaca tggtggacaa gatgtttggc      540

ttcctgggga cttcaggtgg cctgccaggc caggagggcc aggcacctag tggctttgag      600

gacctggagc gagggcggag ggagatggtg gaggaggacc tggatgcagc cctgcccctg      660

cctgacgagg atgaggagga ctctaagtat gttgtggccc tgcaggataa ccccaacccc      720

gcaggcgagg agtcaggctt cctcagcttt gccaagggag acctcatcat cctggaccat      780

gacacgggcg agcaggtcat gaactcgggc tgggccaacg gcatcaatga gaggaccaag      840

cagcgtgggg acttccccac cgacagtgtg tacgtcatgc ccactgtcac catgccaccg      900

cgggagattg tggccctggt caccatgact cccgatcaga ggcaggacgt tgtccggctc      960

ttgcagctgc gaacggcgga gcccgaggtg cgtgccaagc cctacacgct ggaggagttt     1020

tcctatgact acttcaggcc cccacccaag cacacgctga gccgtgtcat ggtgtccaag     1080

gcccgaggca aggaccggct gtggagccac acgcgggaac cgctcaagca ggcgctgctc     1140

aagaagctcc tgggcagtga ggagctctcg caggaggcct gcctggcctt cattgctgtg     1200

ctcaagtaca tgggcgacta cccgtccaag aggacacgct ccgtcaacga gctcaccgac     1260

cagatctttg agggtcccct gaaagccgag cccctgaagg acgaggcata tgtgcagatc     1320

ctgaagcagc tgaccgacaa ccacatcagg tacagcgagg agcggggttg ggagctgctc     1380

tggctgtgca cgggcctttt cccacccagc aacatcctcc tgccccacgt gcagcgcttc     1440

ctgcagtccc gaaagcactg cccactcgcc atcgactgcc tgcaacggct ccagaaagcc     1500

ctgagaaacg ggtcccggaa gtaccctccg cacctggtgg aggtggaggc catccagcac     1560

aagaccaccc agattttcca caaagtctac ttccctgatg acactgacga ggccttcgaa     1620

gtggagtcca gcaccaaggc caaggacttc tgccagaaca tcgccaccag gctgctcctc     1680

aagtcctcag agggattcag cctctttgtc aaaattgcag acaaggtcct cagcgttcct     1740

gagaatgact tcttctttga ctttgttcga cacttgacag actggataaa gaaagctcgg     1800

cccatcaagg acggaattgt gccctcactc acctaccagg tgttcttcat gaagaagctg     1860

tggaccacca cggtgccagg gaaggatccc atggccgatt ccatcttcca ctattaccag     1920

gagttgccca agtatctccg aggctaccac aagtgcacgc gggaggaggt gctgcagctg     1980

ggggcgctga tctacagggt caagttcgag gaggacaagt cctacttccc cagcatcccc     2040

aagctgctgc gggagctggt gccccaggac cttatccggc aggtctcacc tgatgactgg     2100

aagcggtcca tcgtcgccta cttcaacaag cacgcaggga agtccaagga ggaggccaag     2160

ctggccttcc tgaagctcat cttcaagtgg cccacctttg gctcagcctt cttcgaggtg     2220

aagcaaacta cggagccaaa cttccctgag atcctcctaa ttgccatcaa caagtatggg     2280

gtcagcctca tcgatcccaa aacgaaggat atcctcacca ctcatccctt caccaagatc     2340

tccaactgga gcagcggcaa cacctacttc cacatcacca ttgggaactt ggtgcgcggg     2400

agcaaactgc tctgcgagac gtcactgggc tacaagatgg atgacctcct gacttcctac     2460

attagccaga tgctcacagc catgagcaaa cagcggggct ccaggagcgg caagtga        2517


<210>  11
<211>  3462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

cggctgcagg ccctgcaccg ctcccggaag ctgcaccagc agtaccgcct ggcccgccag     1560

cgcatcatcc agttccaggc ccgctgccgc gcctatctgg tgcgcaaggc cttccgccac     1620

cgcctctggg ctgtgctcac cgtgcaggcc tatgcccggg gcatgatcgc ccgcaggctg     1680

caccaacgcc tcagggctga gtatctgtgg cgcctcgagg ctgagaaaat gcggctggcg     1740

gaggaagaga agcttcggaa ggagatgagc gccaagaagg ccaaggagga ggccgagcgc     1800

aagcatcagg agcgcctggc ccagctggct cgtgaggacg ctgagcggga gctgaaggag     1860

aaggaggccg ctcggcggaa gaaggagctc ctggagcaga tggaaagggc ccgccatgag     1920

cctgtcaatc actcagacat ggtggacaag atgtttggct tcctggggac ttcaggtggc     1980

ctgccaggcc aggagggcca ggcacctagt ggctttgagg acctggagcg agggcggagg     2040

gagatggtgg aggaggacct ggatgcagcc ctgcccctgc ctgacgagga tgaggaggac     2100

agtgaggagc tctcgcagga ggcctgcctg gccttcattg ctgtgctcaa gtacatgggc     2160

gactacccgt ccaagaggac acgctccgtc aacgagctca ccgaccagat ctttgagggt     2220

cccctgaaag ccgagcccct gaaggacgag gcatatgtgc agatcctgaa gcagctgacc     2280

gacaaccaca tcaggtacag cgaggagcgg ggttgggagc tgctctggct gtgcacgggc     2340

cttttcccac ccagcaacat cctcctgccc cacgtgcagc gcttcctgca gtcccgaaag     2400

cactgcccac tcgccatcga ctgcctgcaa cggctccaga aagccctgag aaacgggtcc     2460

cggaagtacc ctccgcacct ggtggaggtg gaggccatcc agcacaagac cacccagatt     2520

ttccacaaag tctacttccc tgatgacact gacgaggcct tcgaagtgga gtccagcacc     2580

aaggccaagg acttctgcca gaacatcgcc accaggctgc tcctcaagtc ctcagaggga     2640

ttcagcctct ttgtcaaaat tgcagacaag gtcctcagcg ttcctgagaa tgacttcttc     2700

tttgactttg ttcgacactt gacagactgg ataaagaaag ctcggcccat caaggacgga     2760

attgtgccct cactcaccta ccaggtgttc ttcatgaaga agctgtggac caccacggtg     2820

ccagggaagg atcccatggc cgattccatc ttccactatt accaggagtt gcccaagtat     2880

ctccgaggct accacaagtg cacgcgggag gaggtgctgc agctgggggc gctgatctac     2940

agggtcaagt tcgaggagga caagtcctac ttccccagca tccccaagct gctgcgggag     3000

ctggtgcccc aggaccttat ccggcaggtc tcacctgatg actggaagcg gtccatcgtc     3060

gcctacttca acaagcacgc agggaagtcc aaggaggagg ccaagctggc cttcctgaag     3120

ctcatcttca agtggcccac ctttggctca gccttcttcg aggtgaagca aactacggag     3180

ccaaacttcc ctgagatcct cctaattgcc atcaacaagt atggggtcag cctcatcgat     3240

cccaaaacga aggatatcct caccactcat cccttcacca agatctccaa ctggagcagc     3300

ggcaacacct acttccacat caccattggg aacttggtgc gcgggagcaa actgctctgc     3360

gagacgtcac tgggctacaa gatggatgac ctcctgactt cctacattag ccagatgctc     3420

acagccatga gcaaacagcg gggctccagg agcggcaagt ga                        3462


<210>  12
<211>  2436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
cggctgcagg ccctgcaccg ctcccggaag ctgcaccagc agtaccgcct ggcccgccag       60

cgcatcatcc agttccaggc ccgctgccgc gcctatctgg tgcgcaaggc cttccgccac      120

cgcctctggg ctgtgctcac cgtgcaggcc tatgcccggg gcatgatcgc ccgcaggctg      180

caccaacgcc tcagggctga gtatctgtgg cgcctcgagg ctgagaaaat gcggctggcg      240

gaggaagaga agcttcggaa ggagatgagc gccaagaagg ccaaggagga ggccgagcgc      300

aagcatcagg agcgcctggc ccagctggct cgtgaggacg ctgagcggga gctgaaggag      360

aaggaggccg ctcggcggaa gaaggagctc ctggagcaga tggaaagggc ccgccatgag      420

cctgtcaatc actcagacat ggtggacaag atgtttggct tcctggggac ttcaggtggc      480

ctgccaggcc aggagggcca ggcacctagt ggctttgagg acctggagcg agggcggagg      540

gagatggtgg aggaggacct ggatgcagcc ctgcccctgc ctgacgagga tgaggaggac      600

tctaagtatg ttgtggccct gcaggataac cccaaccccg caggcgagga gtcaggcttc      660

ctcagctttg ccaagggaga cctcatcatc ctggaccatg acacgggcga gcaggtcatg      720

aactcgggct gggccaacgg catcaatgag aggaccaagc agcgtgggga cttccccacc      780

gacagtgtgt acgtcatgcc cactgtcacc atgccaccgc gggagattgt ggccctggtc      840

accatgactc ccgatcagag gcaggacgtt gtccggctct tgcagctgcg aacggcggag      900

cccgaggtgc gtgccaagcc ctacacgctg gaggagtttt cctatgacta cttcaggccc      960

ccacccaagc acacgctgag ccgtgtcatg gtgtccaagg cccgaggcaa ggaccggctg     1020

tggagccaca cgcgggaacc gctcaagcag gcgctgctca agaagctcct gggcagtgag     1080

gagctctcgc aggaggcctg cctggccttc attgctgtgc tcaagtacat gggcgactac     1140

ccgtccaaga ggacacgctc cgtcaacgag ctcaccgacc agatctttga gggtcccctg     1200

aaagccgagc ccctgaagga cgaggcatat gtgcagatcc tgaagcagct gaccgacaac     1260

cacatcaggt acagcgagga gcggggttgg gagctgctct ggctgtgcac gggccttttc     1320

ccacccagca acatcctcct gccccacgtg cagcgcttcc tgcagtcccg aaagcactgc     1380

ccactcgcca tcgactgcct gcaacggctc cagaaagccc tgagaaacgg gtcccggaag     1440

taccctccgc acctggtgga ggtggaggcc atccagcaca agaccaccca gattttccac     1500

aaagtctact tccctgatga cactgacgag gccttcgaag tggagtccag caccaaggcc     1560

aaggacttct gccagaacat cgccaccagg ctgctcctca agtcctcaga gggattcagc     1620

ctctttgtca aaattgcaga caaggtcctc agcgttcctg agaatgactt cttctttgac     1680

tttgttcgac acttgacaga ctggataaag aaagctcggc ccatcaagga cggaattgtg     1740

ccctcactca cctaccaggt gttcttcatg aagaagctgt ggaccaccac ggtgccaggg     1800

aaggatccca tggccgattc catcttccac tattaccagg agttgcccaa gtatctccga     1860

ggctaccaca agtgcacgcg ggaggaggtg ctgcagctgg gggcgctgat ctacagggtc     1920

aagttcgagg aggacaagtc ctacttcccc agcatcccca agctgctgcg ggagctggtg     1980

ccccaggacc ttatccggca ggtctcacct gatgactgga agcggtccat cgtcgcctac     2040

ttcaacaagc acgcagggaa gtccaaggag gaggccaagc tggccttcct gaagctcatc     2100

ttcaagtggc ccacctttgg ctcagccttc ttcgaggtga agcaaactac ggagccaaac     2160

ttccctgaga tcctcctaat tgccatcaac aagtatgggg tcagcctcat cgatcccaaa     2220

acgaaggata tcctcaccac tcatcccttc accaagatct ccaactggag cagcggcaac     2280

acctacttcc acatcaccat tgggaacttg gtgcgcggga gcaaactgct ctgcgagacg     2340

tcactgggct acaagatgga tgacctcctg acttcctaca ttagccagat gctcacagcc     2400

atgagcaaac agcggggctc caggagcggc aagtga                               2436


<210>  13
<211>  1917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt       60

cacaactgta ggaagaacta ctctaagtat gttgtggccc tgcaggataa ccccaacccc      120

gcaggcgagg agtcaggctt cctcagcttt gccaagggag acctcatcat cctggaccat      180

gacacgggcg agcaggtcat gaactcgggc tgggccaacg gcatcaatga gaggaccaag      240

cagcgtgggg acttccccac cgacagtgtg tacgtcatgc ccactgtcac catgccaccg      300

cgggagattg tggccctggt caccatgact cccgatcaga ggcaggacgt tgtccggctc      360

ttgcagctgc gaacggcgga gcccgaggtg cgtgccaagc cctacacgct ggaggagttt      420

tcctatgact acttcaggcc cccacccaag cacacgctga gccgtgtcat ggtgtccaag      480

gcccgaggca aggaccggct gtggagccac acgcgggaac cgctcaagca ggcgctgctc      540

aagaagctcc tgggcagtga ggagctctcg caggaggcct gcctggcctt cattgctgtg      600

ctcaagtaca tgggcgacta cccgtccaag aggacacgct ccgtcaacga gctcaccgac      660

cagatctttg agggtcccct gaaagccgag cccctgaagg acgaggcata tgtgcagatc      720

ctgaagcagc tgaccgacaa ccacatcagg tacagcgagg agcggggttg ggagctgctc      780

tggctgtgca cgggcctttt cccacccagc aacatcctcc tgccccacgt gcagcgcttc      840

ctgcagtccc gaaagcactg cccactcgcc atcgactgcc tgcaacggct ccagaaagcc      900

ctgagaaacg ggtcccggaa gtaccctccg cacctggtgg aggtggaggc catccagcac      960

aagaccaccc agattttcca caaagtctac ttccctgatg acactgacga ggccttcgaa     1020

gtggagtcca gcaccaaggc caaggacttc tgccagaaca tcgccaccag gctgctcctc     1080

aagtcctcag agggattcag cctctttgtc aaaattgcag acaaggtcct cagcgttcct     1140

gagaatgact tcttctttga ctttgttcga cacttgacag actggataaa gaaagctcgg     1200

cccatcaagg acggaattgt gccctcactc acctaccagg tgttcttcat gaagaagctg     1260

tggaccacca cggtgccagg gaaggatccc atggccgatt ccatcttcca ctattaccag     1320

gagttgccca agtatctccg aggctaccac aagtgcacgc gggaggaggt gctgcagctg     1380

ggggcgctga tctacagggt caagttcgag gaggacaagt cctacttccc cagcatcccc     1440

aagctgctgc gggagctggt gccccaggac cttatccggc aggtctcacc tgatgactgg     1500

aagcggtcca tcgtcgccta cttcaacaag cacgcaggga agtccaagga ggaggccaag     1560

ctggccttcc tgaagctcat cttcaagtgg cccacctttg gctcagcctt cttcgaggtg     1620

aagcaaacta cggagccaaa cttccctgag atcctcctaa ttgccatcaa caagtatggg     1680

gtcagcctca tcgatcccaa aacgaaggat atcctcacca ctcatccctt caccaagatc     1740

tccaactgga gcagcggcaa cacctacttc cacatcacca ttgggaactt ggtgcgcggg     1800

agcaaactgc tctgcgagac gtcactgggc tacaagatgg atgacctcct gacttcctac     1860

attagccaga tgctcacagc catgagcaaa cagcggggct ccaggagcgg caagtga        1917


<210>  14
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt       60

cacaactgta ggaagaacta ccggctgcag gccctgcacc gctcccggaa gctgcaccag      120

cagtaccgcc tggcccgcca gcgcatcatc cagttccagg cccgctgccg cgcctatctg      180

gtgcgcaagg ccttccgcca ccgcctctgg gctgtgctca ccgtgcaggc ctatgcccgg      240

ggcatgatcg cccgcaggct gcaccaacgc ctcagggctg agtatctgtg gcgcctcgag      300

gctgagaaaa tgcggctggc ggaggaagag aagcttcgga aggagatgag cgccaagaag      360

gccaaggagg aggccgagcg caagcatcag gagcgcctgg cccagctggc tcgtgaggac      420

gctgagcggg agctgaagga gaaggaggcc gctcggcgga agaaggagct cctggagcag      480

atggaaaggg cccgccatga gcctgtcaat cactcagaca tggtggacaa gatgtttggc      540

ttcctgggga cttcaggtgg cctgccaggc caggagggcc aggcacctag tggctttgag      600

gacctggagc gagggcggag ggagatggtg gaggaggacc tggatgcagc cctgcccctg      660

cctgacgagg atgaggagga ctacacccgg cggccactca aacagccact gctctaccat      720

gacgacgagg gtgaccagct ggcagccctg gcggtctgga tcaccatcct ccgcttcatg      780

ggggacctcc ctgagcccaa gtaccacaca gccatgagtg atggcagtga gaagatccct      840

gtgatgacca agatttatga gaccctgggc aagaagacgt acaagaggga gctgcaggcc      900

ctgcagggcg agggcgaggc ccagctcccc gagggccaga agaagagcag tgtgaggcac      960

aagctggtgc atttgactct gaaaaagaag tccaagctca cagaggaggt gaccaagagg     1020

ctgcatgacg gggagtccac agtgcagggc aacagcatgc tggaggaccg gcccacctcc     1080

aacctggaga agctgcactt catcatcggc aatggcatcc tgcggccagc actccgggac     1140

gagatctact gccagatcag caagcagctg acccacaacc cctccaagag cagctatgcc     1200

cggggctgga ttctcgtgtc tctctgcgtg ggctgtttcg ccccctccga gaagtttgtc     1260

aagtacctgc ggaacttcat ccacgggggc ccgcccggct acgccccgta ctgtgaggag     1320

cgcctgagaa ggacctttgt caatgggaca cggacacagc cgcccagctg gctggagctg     1380

caggccacca agtccaagaa gccaatcatg ttgtctaagt atgttgtggc cctgcaggat     1440

aaccccaacc ccgcaggcga ggagtcaggc ttcctcagct ttgccaaggg agacctcatc     1500

atcctggacc atgacacggg cgagcaggtc atgaactcgg gctgggccaa cggcatcaat     1560

gagaggacca agcagcgtgg ggacttcccc accgacagtg tgtacgtcat gcccactgtc     1620

accatgccac cgcgggagat tgtggccctg gtcaccatga ctcccgatca gaggcaggac     1680

gttgtccggc tcttgcagct gcgaacggcg gagcccgagg tgcgtgccaa gccctacacg     1740

ctggaggagt tttcctatga ctacttcagg cccccaccca agcacacgct gagccgtgtc     1800

atggtgtcca aggcccgagg caaggaccgg ctgtggagcc acacgcggga accgctcaag     1860

caggcgctgc tcaagaagct cctgggcagt gaggagctct cgcaggaggc ctgcctggcc     1920

ttcattgctg tgctcaagta catgggcgac tacccgtcca agaggacacg ctccgtcaac     1980

gagctcaccg accagatctt tgagggtccc ctgaaagccg agcccctgaa ggacgaggca     2040

tatgtgcaga tcctgaagca gctgaccgac aaccacatca ggtacagcga ggagcggggt     2100

tgggagctgc tctggctgtg cacgggcctt ttcccaccca gcaacatcct cctgccccac     2160

gtgcagcgct tcctgcagtc ccgaaagcac tgcccactcg ccatcgactg cctgcaacgg     2220

ctccagaaag ccctgagaaa cgggtcccgg aagtaccctc cgcacctggt ggaggtggag     2280

gccatccag                                                             2289


<210>  15
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Arg Ser Asn Phe Leu Lys Leu Lys Asn Ala Ala Thr 
            500                 505                 510         


Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg Lys Asn Tyr Arg 
        515                 520                 525             


Leu Gln Ala Leu His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu 
    530                 535                 540                 


Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu 
545                 550                 555                 560 


Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln 
                565                 570                 575     


Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg 
            580                 585                 590         


Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu 
        595                 600                 605             


Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu 
    610                 615                 620                 


Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp 
625                 630                 635                 640 


Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu 
                645                 650                 655     


Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser 
            660                 665                 670         


Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu 
        675                 680                 685             


Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg 
    690                 695                 700                 


Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu 
705                 710                 715                 720 


Pro Asp Glu Asp Glu Glu Asp Tyr Thr Arg Arg Pro Leu Lys Gln Pro 
                725                 730                 735     


Leu Leu Tyr His Asp Asp Glu Gly Asp Gln Leu Ala Ala Leu Ala Val 
            740                 745                 750         


Trp Ile Thr Ile Leu Arg Phe Met Gly Asp Leu Pro Glu Pro Lys Tyr 
        755                 760                 765             


His Thr Ala Met Ser Asp Gly Ser Glu Lys Ile Pro Val Met Thr Lys 
    770                 775                 780                 


Ile Tyr Glu Thr Leu Gly Lys Lys Thr Tyr Lys Arg Glu Leu Gln Ala 
785                 790                 795                 800 


Leu Gln Gly Glu Gly Glu Ala Gln Leu Pro Glu Gly Gln Lys Lys Ser 
                805                 810                 815     


Ser Val Arg His Lys Leu Val His Leu Thr Leu Lys Lys Lys Ser Lys 
            820                 825                 830         


Leu Thr Glu Glu Val Thr Lys Arg Leu His Asp Gly Glu Ser Thr Val 
        835                 840                 845             


Gln Gly Asn Ser Met Leu Glu Asp Arg Pro Thr Ser Asn Leu Glu Lys 
    850                 855                 860                 


Leu His Phe Ile Ile Gly Asn Gly Ile Leu Arg Pro Ala Leu Arg Asp 
865                 870                 875                 880 


Glu Ile Tyr Cys Gln Ile Ser Lys Gln Leu Thr His Asn Pro Ser Lys 
                885                 890                 895     


Ser Ser Tyr Ala Arg Gly Trp Ile Leu Val Ser Leu Cys Val Gly Cys 
            900                 905                 910         


Phe Ala Pro Ser Glu Lys Phe Val Lys Tyr Leu Arg Asn Phe Ile His 
        915                 920                 925             


Gly Gly Pro Pro Gly Tyr Ala Pro Tyr Cys Glu Glu Arg Leu Arg Arg 
    930                 935                 940                 


Thr Phe Val Asn Gly Thr Arg Thr Gln Pro Pro Ser Trp Leu Glu Leu 
945                 950                 955                 960 


Gln Ala Thr Lys Ser Lys Lys Pro Ile Met Leu 
                965                 970     


<210>  16
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Leu Leu Phe Ser Arg Phe Tyr Glu Ala Tyr Lys Phe 
            500                 505                 510         


Ser Gly Pro Ser Leu Pro Lys Asn Asp Val Ile Val Ala Val Asn Trp 
        515                 520                 525             


Thr Gly Val Tyr Phe Val Asp Glu Gln Glu Gln Val Leu Leu Glu Leu 
    530                 535                 540                 


Ser Phe Pro Glu Ile Met Ala Val Ser Ser Ser Arg Glu Cys Arg Val 
545                 550                 555                 560 


Trp Leu Ser Leu Gly Cys Ser Asp Leu Gly Cys Ala Ala Pro His Ser 
                565                 570                 575     


Gly Trp Ala Gly Leu Thr Pro Ala Gly Pro Cys Ser Pro Cys Trp Ser 
            580                 585                 590         


Cys Arg Gly Ala Lys Thr Thr Ala Pro Ser Phe Thr Leu Ala Thr Ile 
        595                 600                 605             


Lys Gly Asp Glu Tyr Thr Phe Thr Ser Ser Asn Ala Glu Asp Ile Arg 
    610                 615                 620                 


Asp Leu Val Val Thr Phe Leu Glu Gly Leu Arg Lys Arg Ser Lys Tyr 
625                 630                 635                 640 


Val Val Ala Leu Gln Asp Asn Pro Asn Pro Ala Gly Glu Glu Ser Gly 
                645                 650                 655     


Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile Ile Leu Asp His Asp Thr 
            660                 665                 670         


Gly Glu Gln Val Met Asn Ser Gly Trp Ala Asn Gly Ile Asn Glu Arg 
        675                 680                 685             


Thr Lys Gln Arg Gly Asp Phe Pro Thr Asp Ser Val Tyr Val Met Pro 
    690                 695                 700                 


Thr Val Thr Met Pro Pro Arg Glu Ile Val Ala Leu Val Thr Met Thr 
705                 710                 715                 720 


Pro Asp Gln Arg Gln Asp Val Val Arg Leu Leu Gln Leu Arg Thr Ala 
                725                 730                 735     


Glu Pro Glu Val Arg Ala Lys Pro Tyr Thr Leu Glu Glu Phe Ser Tyr 
            740                 745                 750         


Asp Tyr Phe Arg Pro Pro Pro Lys His Thr Leu Ser Arg Val Met Val 
        755                 760                 765             


Ser Lys Ala Arg Gly Lys Asp Arg Leu Trp Ser His Thr Arg Glu Pro 
    770                 775                 780                 


Leu Lys Gln Ala Leu Leu Lys Lys Leu Leu Gly Ser Glu Glu Leu Ser 
785                 790                 795                 800 


Gln Glu Ala Cys Leu Ala Phe Ile Ala Val Leu Lys Tyr Met Gly Asp 
                805                 810                 815     


Tyr Pro Ser Lys Arg Thr Arg Ser Val Asn Glu Leu Thr Asp Gln Ile 
            820                 825                 830         


Phe Glu Gly Pro Leu Lys Ala Glu Pro Leu Lys Asp Glu Ala Tyr Val 
        835                 840                 845             


Gln Ile Leu Lys Gln Leu Thr Asp Asn His Ile Arg Tyr Ser Glu Glu 
    850                 855                 860                 


Arg Gly Trp Glu Leu Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro Ser 
865                 870                 875                 880 


Asn Ile Leu Leu Pro His Val Gln Arg Phe Leu Gln Ser Arg Lys His 
                885                 890                 895     


Cys Pro Leu Ala Ile Asp Cys Leu Gln Arg Leu Gln Lys Ala Leu Arg 
            900                 905                 910         


Asn Gly Ser Arg Lys Tyr Pro Pro His Leu Val Glu Val Glu Ala Ile 
        915                 920                 925             


Gln 
    


<210>  17
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg 
1               5                   10                  15      


Leu Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr 
            20                  25                  30          


Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala Val Leu Thr Val 
        35                  40                  45              


Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu 
    50                  55                  60                  


Arg Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala 
65                  70                  75                  80  


Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu 
                85                  90                  95      


Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu 
            100                 105                 110         


Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys 
        115                 120                 125             


Glu Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu Pro Val Asn His 
    130                 135                 140                 


Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly 
145                 150                 155                 160 


Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu 
                165                 170                 175     


Arg Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro 
            180                 185                 190         


Leu Pro Asp Glu Asp Glu Glu Asp Leu Leu Phe Ser Arg Phe Tyr Glu 
        195                 200                 205             


Ala Tyr Lys Phe Ser Gly Pro Ser Leu Pro Lys Asn Asp Val Ile Val 
    210                 215                 220                 


Ala Val Asn Trp Thr Gly Val Tyr Phe Val Asp Glu Gln Glu Gln Val 
225                 230                 235                 240 


Leu Leu Glu Leu Ser Phe Pro Glu Ile Met Ala Val Ser Ser Ser Arg 
                245                 250                 255     


Glu Cys Arg Val Trp Leu Ser Leu Gly Cys Ser Asp Leu Gly Cys Ala 
            260                 265                 270         


Ala Pro His Ser Gly Trp Ala Gly Leu Thr Pro Ala Gly Pro Cys Ser 
        275                 280                 285             


Pro Cys Trp Ser Cys Arg Gly Ala Lys Thr Thr Ala Pro Ser Phe Thr 
    290                 295                 300                 


Leu Ala Thr Ile Lys Gly Asp Glu Tyr Thr Phe Thr Ser Ser Asn Ala 
305                 310                 315                 320 


Glu Asp Ile Arg Asp Leu Val Val Thr Phe Leu Glu Gly Leu Arg Lys 
                325                 330                 335     


Arg Ser Lys Tyr Val Val Ala Leu Gln Asp Asn Pro Asn Pro Ala Gly 
            340                 345                 350         


Glu Glu Ser Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile Ile Leu 
        355                 360                 365             


Asp His Asp Thr Gly Glu Gln Val Met Asn Ser Gly Trp Ala Asn Gly 
    370                 375                 380                 


Ile Asn Glu Arg Thr Lys Gln Arg Gly Asp Phe Pro Thr Asp Ser Val 
385                 390                 395                 400 


Tyr Val Met Pro Thr Val Thr Met Pro Pro Arg Glu Ile Val Ala Leu 
                405                 410                 415     


Val Thr Met Thr Pro Asp Gln Arg Gln Asp Val Val Arg Leu Leu Gln 
            420                 425                 430         


Leu Arg Thr Ala Glu Pro Glu Val Arg Ala Lys Pro Tyr Thr Leu Glu 
        435                 440                 445             


Glu Phe Ser Tyr Asp Tyr Phe Arg Pro Pro Pro Lys His Thr Leu Ser 
    450                 455                 460                 


Arg Val Met Val Ser Lys Ala Arg Gly Lys Asp Arg Leu Trp Ser His 
465                 470                 475                 480 


Thr Arg Glu Pro Leu Lys Gln Ala Leu Leu Lys Lys Leu Leu Gly Ser 
                485                 490                 495     


Glu Glu Leu Ser Gln Glu Ala Cys Leu Ala Phe Ile Ala Val Leu Lys 
            500                 505                 510         


Tyr Met Gly Asp Tyr Pro Ser Lys Arg Thr Arg Ser Val Asn Glu Leu 
        515                 520                 525             


Thr Asp Gln Ile Phe Glu Gly Pro Leu Lys Ala Glu Pro Leu Lys Asp 
    530                 535                 540                 


Glu Ala Tyr Val Gln Ile Leu Lys Gln Leu Thr Asp Asn His Ile Arg 
545                 550                 555                 560 


Tyr Ser Glu Glu Arg Gly Trp Glu Leu Leu Trp Leu Cys Thr Gly Leu 
                565                 570                 575     


Phe Pro Pro Ser Asn Ile Leu Leu Pro His Val Gln Arg Phe Leu Gln 
            580                 585                 590         


Ser Arg Lys His Cys Pro Leu Ala Ile Asp Cys Leu Gln Arg Leu Gln 
        595                 600                 605             


Lys Ala Leu Arg Asn Gly Ser Arg Lys Tyr Pro Pro His Leu Val Glu 
    610                 615                 620                 


Val Glu Ala Ile Gln 
625                 


<210>  18
<211>  1158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Leu Leu Phe Ser Arg Phe Tyr 
                725                 730                 735     


Glu Ala Tyr Lys Phe Ser Gly Pro Ser Leu Pro Lys Asn Asp Val Ile 
            740                 745                 750         


Val Ala Val Asn Trp Thr Gly Val Tyr Phe Val Asp Glu Gln Glu Gln 
        755                 760                 765             


Val Leu Leu Glu Leu Ser Phe Pro Glu Ile Met Ala Val Ser Ser Ser 
    770                 775                 780                 


Arg Glu Cys Arg Val Trp Leu Ser Leu Gly Cys Ser Asp Leu Gly Cys 
785                 790                 795                 800 


Ala Ala Pro His Ser Gly Trp Ala Gly Leu Thr Pro Ala Gly Pro Cys 
                805                 810                 815     


Ser Pro Cys Trp Ser Cys Arg Gly Ala Lys Thr Thr Ala Pro Ser Phe 
            820                 825                 830         


Thr Leu Ala Thr Ile Lys Gly Asp Glu Tyr Thr Phe Thr Ser Ser Asn 
        835                 840                 845             


Ala Glu Asp Ile Arg Asp Leu Val Val Thr Phe Leu Glu Gly Leu Arg 
    850                 855                 860                 


Lys Arg Ser Lys Tyr Val Val Ala Leu Gln Asp Asn Pro Asn Pro Ala 
865                 870                 875                 880 


Gly Glu Glu Ser Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile Ile 
                885                 890                 895     


Leu Asp His Asp Thr Gly Glu Gln Val Met Asn Ser Gly Trp Ala Asn 
            900                 905                 910         


Gly Ile Asn Glu Arg Thr Lys Gln Arg Gly Asp Phe Pro Thr Asp Ser 
        915                 920                 925             


Val Tyr Val Met Pro Thr Val Thr Met Pro Pro Arg Glu Ile Val Ala 
    930                 935                 940                 


Leu Val Thr Met Thr Pro Asp Gln Arg Gln Asp Val Val Arg Leu Leu 
945                 950                 955                 960 


Gln Leu Arg Thr Ala Glu Pro Glu Val Arg Ala Lys Pro Tyr Thr Leu 
                965                 970                 975     


Glu Glu Phe Ser Tyr Asp Tyr Phe Arg Pro Pro Pro Lys His Thr Leu 
            980                 985                 990         


Ser Arg Val Met Val Ser Lys Ala  Arg Gly Lys Asp Arg  Leu Trp Ser 
        995                 1000                 1005             


His Thr  Arg Glu Pro Leu Lys  Gln Ala Leu Leu Lys  Lys Leu Leu 
    1010                 1015                 1020             


Gly Ser  Glu Glu Leu Ser Gln  Glu Ala Cys Leu Ala  Phe Ile Ala 
    1025                 1030                 1035             


Val Leu  Lys Tyr Met Gly Asp  Tyr Pro Ser Lys Arg  Thr Arg Ser 
    1040                 1045                 1050             


Val Asn  Glu Leu Thr Asp Gln  Ile Phe Glu Gly Pro  Leu Lys Ala 
    1055                 1060                 1065             


Glu Pro  Leu Lys Asp Glu Ala  Tyr Val Gln Ile Leu  Lys Gln Leu 
    1070                 1075                 1080             


Thr Asp  Asn His Ile Arg Tyr  Ser Glu Glu Arg Gly  Trp Glu Leu 
    1085                 1090                 1095             


Leu Trp  Leu Cys Thr Gly Leu  Phe Pro Pro Ser Asn  Ile Leu Leu 
    1100                 1105                 1110             


Pro His  Val Gln Arg Phe Leu  Gln Ser Arg Lys His  Cys Pro Leu 
    1115                 1120                 1125             


Ala Ile  Asp Cys Leu Gln Arg  Leu Gln Lys Ala Leu  Arg Asn Gly 
    1130                 1135                 1140             


Ser Arg  Lys Tyr Pro Pro His  Leu Val Glu Val Glu  Ala Ile Gln 
    1145                 1150                 1155             


<210>  19
<211>  1236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His 
            500                 505                 510         


Gln Gln Tyr Arg Leu Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg 
        515                 520                 525             


Cys Arg Ala Tyr Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala 
    530                 535                 540                 


Val Leu Thr Val Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu 
545                 550                 555                 560 


His Gln Arg Leu Arg Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys 
                565                 570                 575     


Met Arg Leu Ala Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys 
            580                 585                 590         


Lys Ala Lys Glu Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln 
        595                 600                 605             


Leu Ala Arg Glu Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala 
    610                 615                 620                 


Arg Arg Lys Lys Glu Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu 
625                 630                 635                 640 


Pro Val Asn His Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly 
                645                 650                 655     


Thr Ser Gly Gly Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe 
            660                 665                 670         


Glu Asp Leu Glu Arg Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp 
        675                 680                 685             


Ala Ala Leu Pro Leu Pro Asp Glu Asp Glu Glu Asp Tyr Thr Arg Arg 
    690                 695                 700                 


Pro Leu Lys Gln Pro Leu Leu Tyr His Asp Asp Glu Gly Asp Gln Leu 
705                 710                 715                 720 


Ala Ala Leu Ala Val Trp Ile Thr Ile Leu Arg Phe Met Gly Asp Leu 
                725                 730                 735     


Pro Glu Pro Lys Tyr His Thr Ala Met Ser Asp Gly Ser Glu Lys Ile 
            740                 745                 750         


Pro Val Met Thr Lys Ile Tyr Glu Thr Leu Gly Lys Lys Thr Tyr Lys 
        755                 760                 765             


Arg Glu Leu Gln Ala Leu Gln Gly Glu Gly Glu Ala Gln Leu Pro Glu 
    770                 775                 780                 


Gly Gln Lys Lys Ser Ser Val Arg His Lys Leu Val His Leu Thr Leu 
785                 790                 795                 800 


Lys Lys Lys Ser Lys Leu Thr Glu Glu Val Thr Lys Arg Leu His Asp 
                805                 810                 815     


Gly Glu Ser Thr Val Gln Gly Asn Ser Met Leu Glu Asp Arg Pro Thr 
            820                 825                 830         


Ser Asn Leu Glu Lys Leu His Phe Ile Ile Gly Asn Gly Ile Leu Arg 
        835                 840                 845             


Pro Ala Leu Arg Asp Glu Ile Tyr Cys Gln Ile Ser Lys Gln Leu Thr 
    850                 855                 860                 


His Asn Pro Ser Lys Ser Ser Tyr Ala Arg Gly Trp Ile Leu Val Ser 
865                 870                 875                 880 


Leu Cys Val Gly Cys Phe Ala Pro Ser Glu Lys Phe Val Lys Tyr Leu 
                885                 890                 895     


Arg Asn Phe Ile His Gly Gly Pro Pro Gly Tyr Ala Pro Tyr Cys Glu 
            900                 905                 910         


Glu Arg Leu Arg Arg Thr Phe Val Asn Gly Thr Arg Thr Gln Pro Pro 
        915                 920                 925             


Ser Trp Leu Glu Leu Gln Ala Thr Lys Ser Lys Lys Pro Ile Met Leu 
    930                 935                 940                 


Ser Lys Tyr Val Val Ala Leu Gln Asp Asn Pro Asn Pro Ala Gly Glu 
945                 950                 955                 960 


Glu Ser Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile Ile Leu Asp 
                965                 970                 975     


His Asp Thr Gly Glu Gln Val Met Asn Ser Gly Trp Ala Asn Gly Ile 
            980                 985                 990         


Asn Glu Arg Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Ser Val Tyr 
        995                 1000                 1005             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1010                 1015                 1020             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1025                 1030                 1035             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1040                 1045                 1050             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1055                 1060                 1065             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1070                 1075                 1080             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1085                 1090                 1095             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1100                 1105                 1110             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1115                 1120                 1125             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1130                 1135                 1140             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1145                 1150                 1155             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1160                 1165                 1170             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1175                 1180                 1185             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1190                 1195                 1200             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1205                 1210                 1215             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1220                 1225                 1230             


Ala Ile  Gln 
    1235     


<210>  20
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg 
1               5                   10                  15      


Leu Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr 
            20                  25                  30          


Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala Val Leu Thr Val 
        35                  40                  45              


Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu 
    50                  55                  60                  


Arg Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala 
65                  70                  75                  80  


Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu 
                85                  90                  95      


Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu 
            100                 105                 110         


Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys 
        115                 120                 125             


Glu Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu Pro Val Asn His 
    130                 135                 140                 


Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly 
145                 150                 155                 160 


Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu 
                165                 170                 175     


Arg Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro 
            180                 185                 190         


Leu Pro Asp Glu Asp Glu Glu Asp Leu Leu Phe Ser Arg Phe Tyr Glu 
        195                 200                 205             


Ala Tyr Lys Phe Ser Gly Pro Ser Leu Pro Lys Asn Asp Val Ile Val 
    210                 215                 220                 


Ala Val Asn Trp Thr Gly Val Tyr Phe Val Asp Glu Gln Glu Gln Val 
225                 230                 235                 240 


Leu Leu Glu Leu Ser Phe Pro Glu Ile Met Ala Val Ser Ser Ser Arg 
                245                 250                 255     


Glu Cys Arg Val Trp Leu Ser Leu Gly Cys Ser Asp Leu Gly Cys Ala 
            260                 265                 270         


Ala Pro His Ser Gly Trp Ala Gly Leu Thr Pro Ala Gly Pro Cys Ser 
        275                 280                 285             


Pro Cys Trp Ser Cys Arg Gly Ala Lys Thr Thr Ala Pro Ser Phe Thr 
    290                 295                 300                 


Leu Ala Thr Ile Lys Gly Asp Glu Tyr Thr Phe Thr Ser Ser Asn Ala 
305                 310                 315                 320 


Glu Asp Ile Arg Asp Leu Val Val Thr Phe Leu Glu Gly Leu Arg Lys 
                325                 330                 335     


Arg Ser Lys Tyr Val Val Ala Leu Gln Asp Asn Pro Asn Pro Ala Gly 
            340                 345                 350         


Glu Glu Ser Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile Ile Leu 
        355                 360                 365             


Asp His Asp Thr Gly Glu Gln Val Met Asn Ser Gly Trp Ala Asn Gly 
    370                 375                 380                 


Ile Asn Glu Arg Thr Lys Gln Arg Gly Asp Phe Pro Thr Asp Ser Val 
385                 390                 395                 400 


Tyr Val Met Pro Thr Val Thr Met Pro Pro Arg Glu Ile Val Ala Leu 
                405                 410                 415     


Val Thr Met Thr Pro Asp Gln Arg Gln Asp Val Val Arg Leu Leu Gln 
            420                 425                 430         


Leu Arg Thr Ala Glu Pro Glu Val Arg Ala Lys Pro Tyr Thr Leu Glu 
        435                 440                 445             


Glu Phe Ser Tyr Asp Tyr Phe Arg Pro Pro Pro Lys His Thr Leu Ser 
    450                 455                 460                 


Arg Val Met Val Ser Lys Ala Arg Gly Lys Asp Arg Leu Trp Ser His 
465                 470                 475                 480 


Thr Arg Glu Pro Leu Lys Gln Ala Leu Leu Lys Lys Leu Leu Gly Ser 
                485                 490                 495     


Glu Glu Leu Ser Gln Glu Ala Cys Leu Ala Phe Ile Ala Val Leu Lys 
            500                 505                 510         


Tyr Met Gly Asp Tyr Pro Ser Lys Arg Thr Arg Ser Val Asn Glu Leu 
        515                 520                 525             


Thr Asp Gln Ile Phe Glu Gly Pro Leu Lys Ala Glu Pro Leu Lys Asp 
    530                 535                 540                 


Glu Ala Tyr Val Gln Ile Leu Lys Gln Leu Thr Asp Asn His Ile Arg 
545                 550                 555                 560 


Tyr Ser Glu Glu Arg Gly Trp Glu Leu Leu Trp Leu Cys Thr Gly Leu 
                565                 570                 575     


Phe Pro Pro Ser Asn Ile Leu Leu Pro His Val Gln Arg Phe Leu Gln 
            580                 585                 590         


Ser Arg Lys His Cys Pro Leu Ala Ile Asp Cys Leu Gln Arg Leu Gln 
        595                 600                 605             


Lys Ala Leu Arg Asn Gly Ser Arg Lys Tyr Pro Pro His Leu Val Glu 
    610                 615                 620                 


Val Glu Ala Ile Gln 
625                 


<210>  21
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Leu Leu Phe Ser Arg Phe Tyr Glu Ala Tyr Lys Phe Ser Gly Pro Ser 
1               5                   10                  15      


Leu Pro Lys Asn Asp Val Ile Val Ala Val Asn Trp Thr Gly Val Tyr 
            20                  25                  30          


Phe Val Asp Glu Gln Glu Gln Val Leu Leu Glu Leu Ser Phe Pro Glu 
        35                  40                  45              


Ile Met Ala Val Ser Ser Ser Arg Glu Cys Arg Val Trp Leu Ser Leu 
    50                  55                  60                  


Gly Cys Ser Asp Leu Gly Cys Ala Ala Pro His Ser Gly Trp Ala Gly 
65                  70                  75                  80  


Leu Thr Pro Ala Gly Pro Cys Ser Pro Cys Trp Ser Cys Arg Gly Ala 
                85                  90                  95      


Lys Thr Thr Ala Pro Ser Phe Thr Leu Ala Thr Ile Lys Gly Asp Glu 
            100                 105                 110         


Tyr Thr Phe Thr Ser Ser Asn Ala Glu Asp Ile Arg Asp Leu Val Val 
        115                 120                 125             


Thr Phe Leu Glu Gly Leu Arg Lys Arg Ser Lys Tyr Val Val Ala Leu 
    130                 135                 140                 


Gln Asp Asn Pro Asn Pro Ala Gly Glu Glu Ser Gly Phe Leu Ser Phe 
145                 150                 155                 160 


Ala Lys Gly Asp Leu Ile Ile Leu Asp His Asp Thr Gly Glu Gln Val 
                165                 170                 175     


Met Asn Ser Gly Trp Ala Asn Gly Ile Asn Glu Arg Thr Lys Gln Arg 
            180                 185                 190         


Gly Asp Phe Pro Thr Asp Ser Val Tyr Val Met Pro Thr Val Thr Met 
        195                 200                 205             


Pro Pro Arg Glu Ile Val Ala Leu Val Thr Met Thr Pro Asp Gln Arg 
    210                 215                 220                 


Gln Asp Val Val Arg Leu Leu Gln Leu Arg Thr Ala Glu Pro Glu Val 
225                 230                 235                 240 


Arg Ala Lys Pro Tyr Thr Leu Glu Glu Phe Ser Tyr Asp Tyr Phe Arg 
                245                 250                 255     


Pro Pro Pro Lys His Thr Leu Ser Arg Val Met Val Ser Lys Ala Arg 
            260                 265                 270         


Gly Lys Asp Arg Leu Trp Ser His Thr Arg Glu Pro Leu Lys Gln Ala 
        275                 280                 285             


Leu Leu Lys Lys Leu Leu Gly Ser Glu Glu Leu Ser Gln Glu Ala Cys 
    290                 295                 300                 


Leu Ala Phe Ile Ala Val Leu Lys Tyr Met Gly Asp Tyr Pro Ser Lys 
305                 310                 315                 320 


Arg Thr Arg Ser Val Asn Glu Leu Thr Asp Gln Ile Phe Glu Gly Pro 
                325                 330                 335     


Leu Lys Ala Glu Pro Leu Lys Asp Glu Ala Tyr Val Gln Ile Leu Lys 
            340                 345                 350         


Gln Leu Thr Asp Asn His Ile Arg Tyr Ser Glu Glu Arg Gly Trp Glu 
        355                 360                 365             


Leu Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro Ser Asn Ile Leu Leu 
    370                 375                 380                 


Pro His Val Gln Arg Phe Leu Gln Ser Arg Lys His Cys Pro Leu Ala 
385                 390                 395                 400 


Ile Asp Cys Leu Gln Arg Leu Gln Lys Ala Leu Arg Asn Gly Ser Arg 
                405                 410                 415     


Lys Tyr Pro Pro His Leu Val Glu Val Glu Ala Ile Gln 
            420                 425                 


<210>  22
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Arg Ser Asn Phe Leu Lys Leu Lys Asn Ala Ala Thr Leu Ile Gln Arg 
1               5                   10                  15      


His Trp Arg Gly His Asn Cys Arg Lys Asn Tyr Arg Leu Gln Ala Leu 
            20                  25                  30          


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
        35                  40                  45              


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
    50                  55                  60                  


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
65                  70                  75                  80  


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
                85                  90                  95      


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
            100                 105                 110         


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
        115                 120                 125             


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
    130                 135                 140                 


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
145                 150                 155                 160 


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
                165                 170                 175     


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
            180                 185                 190         


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
        195                 200                 205             


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
    210                 215                 220                 


Glu Glu Asp Ser Lys Tyr Val Val Ala Leu Gln Asp Asn Pro Asn Pro 
225                 230                 235                 240 


Ala Gly Glu Glu Ser Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile 
                245                 250                 255     


Ile Leu Asp His Asp Thr Gly Glu Gln Val Met Asn Ser Gly Trp Ala 
            260                 265                 270         


Asn Gly Ile Asn Glu Arg Thr Lys Gln Arg Gly Asp Phe Pro Thr Asp 
        275                 280                 285             


Ser Val Tyr Val Met Pro Thr Val Thr Met Pro Pro Arg Glu Ile Val 
    290                 295                 300                 


Ala Leu Val Thr Met Thr Pro Asp Gln Arg Gln Asp Val Val Arg Leu 
305                 310                 315                 320 


Leu Gln Leu Arg Thr Ala Glu Pro Glu Val Arg Ala Lys Pro Tyr Thr 
                325                 330                 335     


Leu Glu Glu Phe Ser Tyr Asp Tyr Phe Arg Pro Pro Pro Lys His Thr 
            340                 345                 350         


Leu Ser Arg Val Met Val Ser Lys Ala Arg Gly Lys Asp Arg Leu Trp 
        355                 360                 365             


Ser His Thr Arg Glu Pro Leu Lys Gln Ala Leu Leu Lys Lys Leu Leu 
    370                 375                 380                 


Gly Ser Glu Glu Leu Ser Gln Glu Ala Cys Leu Ala Phe Ile Ala Val 
385                 390                 395                 400 


Leu Lys Tyr Met Gly Asp Tyr Pro Ser Lys Arg Thr Arg Ser Val Asn 
                405                 410                 415     


Glu Leu Thr Asp Gln Ile Phe Glu Gly Pro Leu Lys Ala Glu Pro Leu 
            420                 425                 430         


Lys Asp Glu Ala Tyr Val Gln Ile Leu Lys Gln Leu Thr Asp Asn His 
        435                 440                 445             


Ile Arg Tyr Ser Glu Glu Arg Gly Trp Glu Leu Leu Trp Leu Cys Thr 
    450                 455                 460                 


Gly Leu Phe Pro Pro Ser Asn Ile Leu Leu Pro His Val Gln Arg Phe 
465                 470                 475                 480 


Leu Gln Ser Arg Lys His Cys Pro Leu Ala Ile Asp Cys Leu Gln Arg 
                485                 490                 495     


Leu Gln Lys Ala Leu Arg Asn Gly Ser Arg Lys Tyr Pro Pro His Leu 
            500                 505                 510         


Val Glu Val Glu Ala Ile Gln His Lys Thr Thr Gln Ile Phe His Lys 
        515                 520                 525             


Val Tyr Phe Pro Asp Asp Thr Asp Glu Ala Phe Glu Val Glu Ser Ser 
    530                 535                 540                 


Thr Lys Ala Lys Asp Phe Cys Gln Asn Ile Ala Thr Arg Leu Leu Leu 
545                 550                 555                 560 


Lys Ser Ser Glu Gly Phe Ser Leu Phe Val Lys Ile Ala Asp Lys Val 
                565                 570                 575     


Leu Ser Val Pro Glu Asn Asp Phe Phe Phe Asp Phe Val Arg His Leu 
            580                 585                 590         


Thr Asp Trp Ile Lys Lys Ala Arg Pro Ile Lys Asp Gly Ile Val Pro 
        595                 600                 605             


Ser Leu Thr Tyr Gln Val Phe Phe Met Lys Lys Leu Trp Thr Thr Thr 
    610                 615                 620                 


Val Pro Gly Lys Asp Pro Met Ala Asp Ser Ile Phe His Tyr Tyr Gln 
625                 630                 635                 640 


Glu Leu Pro Lys Tyr Leu Arg Gly Tyr His Lys Cys Thr Arg Glu Glu 
                645                 650                 655     


Val Leu Gln Leu Gly Ala Leu Ile Tyr Arg Val Lys Phe Glu Glu Asp 
            660                 665                 670         


Lys Ser Tyr Phe Pro Ser Ile Pro Lys Leu Leu Arg Glu Leu Val Pro 
        675                 680                 685             


Gln Asp Leu Ile Arg Gln Val Ser Pro Asp Asp Trp Lys Arg Ser Ile 
    690                 695                 700                 


Val Ala Tyr Phe Asn Lys His Ala Gly Lys Ser Lys Glu Glu Ala Lys 
705                 710                 715                 720 


Leu Ala Phe Leu Lys Leu Ile Phe Lys Trp Pro Thr Phe Gly Ser Ala 
                725                 730                 735     


Phe Phe Glu Val Lys Gln Thr Thr Glu Pro Asn Phe Pro Glu Ile Leu 
            740                 745                 750         


Leu Ile Ala Ile Asn Lys Tyr Gly Val Ser Leu Ile Asp Pro Lys Thr 
        755                 760                 765             


Lys Asp Ile Leu Thr Thr His Pro Phe Thr Lys Ile Ser Asn Trp Ser 
    770                 775                 780                 


Ser Gly Asn Thr Tyr Phe His Ile Thr Ile Gly Asn Leu Val Arg Gly 
785                 790                 795                 800 


Ser Lys Leu Leu Cys Glu Thr Ser Leu Gly Tyr Lys Met Asp Asp Leu 
                805                 810                 815     


Leu Thr Ser Tyr Ile Ser Gln Met Leu Thr Ala Met Ser Lys Gln Arg 
            820                 825                 830         


Gly Ser Arg Ser Gly Lys 
        835             


<210>  23
<211>  1153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His 
            500                 505                 510         


Gln Gln Tyr Arg Leu Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg 
        515                 520                 525             


Cys Arg Ala Tyr Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala 
    530                 535                 540                 


Val Leu Thr Val Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu 
545                 550                 555                 560 


His Gln Arg Leu Arg Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys 
                565                 570                 575     


Met Arg Leu Ala Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys 
            580                 585                 590         


Lys Ala Lys Glu Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln 
        595                 600                 605             


Leu Ala Arg Glu Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala 
    610                 615                 620                 


Arg Arg Lys Lys Glu Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu 
625                 630                 635                 640 


Pro Val Asn His Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly 
                645                 650                 655     


Thr Ser Gly Gly Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe 
            660                 665                 670         


Glu Asp Leu Glu Arg Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp 
        675                 680                 685             


Ala Ala Leu Pro Leu Pro Asp Glu Asp Glu Glu Asp Ser Glu Glu Leu 
    690                 695                 700                 


Ser Gln Glu Ala Cys Leu Ala Phe Ile Ala Val Leu Lys Tyr Met Gly 
705                 710                 715                 720 


Asp Tyr Pro Ser Lys Arg Thr Arg Ser Val Asn Glu Leu Thr Asp Gln 
                725                 730                 735     


Ile Phe Glu Gly Pro Leu Lys Ala Glu Pro Leu Lys Asp Glu Ala Tyr 
            740                 745                 750         


Val Gln Ile Leu Lys Gln Leu Thr Asp Asn His Ile Arg Tyr Ser Glu 
        755                 760                 765             


Glu Arg Gly Trp Glu Leu Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro 
    770                 775                 780                 


Ser Asn Ile Leu Leu Pro His Val Gln Arg Phe Leu Gln Ser Arg Lys 
785                 790                 795                 800 


His Cys Pro Leu Ala Ile Asp Cys Leu Gln Arg Leu Gln Lys Ala Leu 
                805                 810                 815     


Arg Asn Gly Ser Arg Lys Tyr Pro Pro His Leu Val Glu Val Glu Ala 
            820                 825                 830         


Ile Gln His Lys Thr Thr Gln Ile Phe His Lys Val Tyr Phe Pro Asp 
        835                 840                 845             


Asp Thr Asp Glu Ala Phe Glu Val Glu Ser Ser Thr Lys Ala Lys Asp 
    850                 855                 860                 


Phe Cys Gln Asn Ile Ala Thr Arg Leu Leu Leu Lys Ser Ser Glu Gly 
865                 870                 875                 880 


Phe Ser Leu Phe Val Lys Ile Ala Asp Lys Val Leu Ser Val Pro Glu 
                885                 890                 895     


Asn Asp Phe Phe Phe Asp Phe Val Arg His Leu Thr Asp Trp Ile Lys 
            900                 905                 910         


Lys Ala Arg Pro Ile Lys Asp Gly Ile Val Pro Ser Leu Thr Tyr Gln 
        915                 920                 925             


Val Phe Phe Met Lys Lys Leu Trp Thr Thr Thr Val Pro Gly Lys Asp 
    930                 935                 940                 


Pro Met Ala Asp Ser Ile Phe His Tyr Tyr Gln Glu Leu Pro Lys Tyr 
945                 950                 955                 960 


Leu Arg Gly Tyr His Lys Cys Thr Arg Glu Glu Val Leu Gln Leu Gly 
                965                 970                 975     


Ala Leu Ile Tyr Arg Val Lys Phe Glu Glu Asp Lys Ser Tyr Phe Pro 
            980                 985                 990         


Ser Ile Pro Lys Leu Leu Arg Glu  Leu Val Pro Gln Asp  Leu Ile Arg 
        995                 1000                 1005             


Gln Val  Ser Pro Asp Asp Trp  Lys Arg Ser Ile Val  Ala Tyr Phe 
    1010                 1015                 1020             


Asn Lys  His Ala Gly Lys Ser  Lys Glu Glu Ala Lys  Leu Ala Phe 
    1025                 1030                 1035             


Leu Lys  Leu Ile Phe Lys Trp  Pro Thr Phe Gly Ser  Ala Phe Phe 
    1040                 1045                 1050             


Glu Val  Lys Gln Thr Thr Glu  Pro Asn Phe Pro Glu  Ile Leu Leu 
    1055                 1060                 1065             


Ile Ala  Ile Asn Lys Tyr Gly  Val Ser Leu Ile Asp  Pro Lys Thr 
    1070                 1075                 1080             


Lys Asp  Ile Leu Thr Thr His  Pro Phe Thr Lys Ile  Ser Asn Trp 
    1085                 1090                 1095             


Ser Ser  Gly Asn Thr Tyr Phe  His Ile Thr Ile Gly  Asn Leu Val 
    1100                 1105                 1110             


Arg Gly  Ser Lys Leu Leu Cys  Glu Thr Ser Leu Gly  Tyr Lys Met 
    1115                 1120                 1125             


Asp Asp  Leu Leu Thr Ser Tyr  Ile Ser Gln Met Leu  Thr Ala Met 
    1130                 1135                 1140             


Ser Lys  Gln Arg Gly Ser Arg  Ser Gly Lys 
    1145                 1150             


<210>  24
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg 
1               5                   10                  15      


Leu Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr 
            20                  25                  30          


Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala Val Leu Thr Val 
        35                  40                  45              


Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu 
    50                  55                  60                  


Arg Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala 
65                  70                  75                  80  


Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu 
                85                  90                  95      


Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu 
            100                 105                 110         


Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys 
        115                 120                 125             


Glu Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu Pro Val Asn His 
    130                 135                 140                 


Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly 
145                 150                 155                 160 


Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu 
                165                 170                 175     


Arg Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro 
            180                 185                 190         


Leu Pro Asp Glu Asp Glu Glu Asp Ser Lys Tyr Val Val Ala Leu Gln 
        195                 200                 205             


Asp Asn Pro Asn Pro Ala Gly Glu Glu Ser Gly Phe Leu Ser Phe Ala 
    210                 215                 220                 


Lys Gly Asp Leu Ile Ile Leu Asp His Asp Thr Gly Glu Gln Val Met 
225                 230                 235                 240 


Asn Ser Gly Trp Ala Asn Gly Ile Asn Glu Arg Thr Lys Gln Arg Gly 
                245                 250                 255     


Asp Phe Pro Thr Asp Ser Val Tyr Val Met Pro Thr Val Thr Met Pro 
            260                 265                 270         


Pro Arg Glu Ile Val Ala Leu Val Thr Met Thr Pro Asp Gln Arg Gln 
        275                 280                 285             


Asp Val Val Arg Leu Leu Gln Leu Arg Thr Ala Glu Pro Glu Val Arg 
    290                 295                 300                 


Ala Lys Pro Tyr Thr Leu Glu Glu Phe Ser Tyr Asp Tyr Phe Arg Pro 
305                 310                 315                 320 


Pro Pro Lys His Thr Leu Ser Arg Val Met Val Ser Lys Ala Arg Gly 
                325                 330                 335     


Lys Asp Arg Leu Trp Ser His Thr Arg Glu Pro Leu Lys Gln Ala Leu 
            340                 345                 350         


Leu Lys Lys Leu Leu Gly Ser Glu Glu Leu Ser Gln Glu Ala Cys Leu 
        355                 360                 365             


Ala Phe Ile Ala Val Leu Lys Tyr Met Gly Asp Tyr Pro Ser Lys Arg 
    370                 375                 380                 


Thr Arg Ser Val Asn Glu Leu Thr Asp Gln Ile Phe Glu Gly Pro Leu 
385                 390                 395                 400 


Lys Ala Glu Pro Leu Lys Asp Glu Ala Tyr Val Gln Ile Leu Lys Gln 
                405                 410                 415     


Leu Thr Asp Asn His Ile Arg Tyr Ser Glu Glu Arg Gly Trp Glu Leu 
            420                 425                 430         


Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro Ser Asn Ile Leu Leu Pro 
        435                 440                 445             


His Val Gln Arg Phe Leu Gln Ser Arg Lys His Cys Pro Leu Ala Ile 
    450                 455                 460                 


Asp Cys Leu Gln Arg Leu Gln Lys Ala Leu Arg Asn Gly Ser Arg Lys 
465                 470                 475                 480 


Tyr Pro Pro His Leu Val Glu Val Glu Ala Ile Gln His Lys Thr Thr 
                485                 490                 495     


Gln Ile Phe His Lys Val Tyr Phe Pro Asp Asp Thr Asp Glu Ala Phe 
            500                 505                 510         


Glu Val Glu Ser Ser Thr Lys Ala Lys Asp Phe Cys Gln Asn Ile Ala 
        515                 520                 525             


Thr Arg Leu Leu Leu Lys Ser Ser Glu Gly Phe Ser Leu Phe Val Lys 
    530                 535                 540                 


Ile Ala Asp Lys Val Leu Ser Val Pro Glu Asn Asp Phe Phe Phe Asp 
545                 550                 555                 560 


Phe Val Arg His Leu Thr Asp Trp Ile Lys Lys Ala Arg Pro Ile Lys 
                565                 570                 575     


Asp Gly Ile Val Pro Ser Leu Thr Tyr Gln Val Phe Phe Met Lys Lys 
            580                 585                 590         


Leu Trp Thr Thr Thr Val Pro Gly Lys Asp Pro Met Ala Asp Ser Ile 
        595                 600                 605             


Phe His Tyr Tyr Gln Glu Leu Pro Lys Tyr Leu Arg Gly Tyr His Lys 
    610                 615                 620                 


Cys Thr Arg Glu Glu Val Leu Gln Leu Gly Ala Leu Ile Tyr Arg Val 
625                 630                 635                 640 


Lys Phe Glu Glu Asp Lys Ser Tyr Phe Pro Ser Ile Pro Lys Leu Leu 
                645                 650                 655     


Arg Glu Leu Val Pro Gln Asp Leu Ile Arg Gln Val Ser Pro Asp Asp 
            660                 665                 670         


Trp Lys Arg Ser Ile Val Ala Tyr Phe Asn Lys His Ala Gly Lys Ser 
        675                 680                 685             


Lys Glu Glu Ala Lys Leu Ala Phe Leu Lys Leu Ile Phe Lys Trp Pro 
    690                 695                 700                 


Thr Phe Gly Ser Ala Phe Phe Glu Val Lys Gln Thr Thr Glu Pro Asn 
705                 710                 715                 720 


Phe Pro Glu Ile Leu Leu Ile Ala Ile Asn Lys Tyr Gly Val Ser Leu 
                725                 730                 735     


Ile Asp Pro Lys Thr Lys Asp Ile Leu Thr Thr His Pro Phe Thr Lys 
            740                 745                 750         


Ile Ser Asn Trp Ser Ser Gly Asn Thr Tyr Phe His Ile Thr Ile Gly 
        755                 760                 765             


Asn Leu Val Arg Gly Ser Lys Leu Leu Cys Glu Thr Ser Leu Gly Tyr 
    770                 775                 780                 


Lys Met Asp Asp Leu Leu Thr Ser Tyr Ile Ser Gln Met Leu Thr Ala 
785                 790                 795                 800 


Met Ser Lys Gln Arg Gly Ser Arg Ser Gly Lys 
                805                 810     


<210>  25
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Arg Ser Asn Phe Leu Lys Leu Lys Asn Ala Ala Thr Leu Ile Gln Arg 
1               5                   10                  15      


His Trp Arg Gly His Asn Cys Arg Lys Asn Tyr Ser Lys Tyr Val Val 
            20                  25                  30          


Ala Leu Gln Asp Asn Pro Asn Pro Ala Gly Glu Glu Ser Gly Phe Leu 
        35                  40                  45              


Ser Phe Ala Lys Gly Asp Leu Ile Ile Leu Asp His Asp Thr Gly Glu 
    50                  55                  60                  


Gln Val Met Asn Ser Gly Trp Ala Asn Gly Ile Asn Glu Arg Thr Lys 
65                  70                  75                  80  


Gln Arg Gly Asp Phe Pro Thr Asp Ser Val Tyr Val Met Pro Thr Val 
                85                  90                  95      


Thr Met Pro Pro Arg Glu Ile Val Ala Leu Val Thr Met Thr Pro Asp 
            100                 105                 110         


Gln Arg Gln Asp Val Val Arg Leu Leu Gln Leu Arg Thr Ala Glu Pro 
        115                 120                 125             


Glu Val Arg Ala Lys Pro Tyr Thr Leu Glu Glu Phe Ser Tyr Asp Tyr 
    130                 135                 140                 


Phe Arg Pro Pro Pro Lys His Thr Leu Ser Arg Val Met Val Ser Lys 
145                 150                 155                 160 


Ala Arg Gly Lys Asp Arg Leu Trp Ser His Thr Arg Glu Pro Leu Lys 
                165                 170                 175     


Gln Ala Leu Leu Lys Lys Leu Leu Gly Ser Glu Glu Leu Ser Gln Glu 
            180                 185                 190         


Ala Cys Leu Ala Phe Ile Ala Val Leu Lys Tyr Met Gly Asp Tyr Pro 
        195                 200                 205             


Ser Lys Arg Thr Arg Ser Val Asn Glu Leu Thr Asp Gln Ile Phe Glu 
    210                 215                 220                 


Gly Pro Leu Lys Ala Glu Pro Leu Lys Asp Glu Ala Tyr Val Gln Ile 
225                 230                 235                 240 


Leu Lys Gln Leu Thr Asp Asn His Ile Arg Tyr Ser Glu Glu Arg Gly 
                245                 250                 255     


Trp Glu Leu Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro Ser Asn Ile 
            260                 265                 270         


Leu Leu Pro His Val Gln Arg Phe Leu Gln Ser Arg Lys His Cys Pro 
        275                 280                 285             


Leu Ala Ile Asp Cys Leu Gln Arg Leu Gln Lys Ala Leu Arg Asn Gly 
    290                 295                 300                 


Ser Arg Lys Tyr Pro Pro His Leu Val Glu Val Glu Ala Ile Gln His 
305                 310                 315                 320 


Lys Thr Thr Gln Ile Phe His Lys Val Tyr Phe Pro Asp Asp Thr Asp 
                325                 330                 335     


Glu Ala Phe Glu Val Glu Ser Ser Thr Lys Ala Lys Asp Phe Cys Gln 
            340                 345                 350         


Asn Ile Ala Thr Arg Leu Leu Leu Lys Ser Ser Glu Gly Phe Ser Leu 
        355                 360                 365             


Phe Val Lys Ile Ala Asp Lys Val Leu Ser Val Pro Glu Asn Asp Phe 
    370                 375                 380                 


Phe Phe Asp Phe Val Arg His Leu Thr Asp Trp Ile Lys Lys Ala Arg 
385                 390                 395                 400 


Pro Ile Lys Asp Gly Ile Val Pro Ser Leu Thr Tyr Gln Val Phe Phe 
                405                 410                 415     


Met Lys Lys Leu Trp Thr Thr Thr Val Pro Gly Lys Asp Pro Met Ala 
            420                 425                 430         


Asp Ser Ile Phe His Tyr Tyr Gln Glu Leu Pro Lys Tyr Leu Arg Gly 
        435                 440                 445             


Tyr His Lys Cys Thr Arg Glu Glu Val Leu Gln Leu Gly Ala Leu Ile 
    450                 455                 460                 


Tyr Arg Val Lys Phe Glu Glu Asp Lys Ser Tyr Phe Pro Ser Ile Pro 
465                 470                 475                 480 


Lys Leu Leu Arg Glu Leu Val Pro Gln Asp Leu Ile Arg Gln Val Ser 
                485                 490                 495     


Pro Asp Asp Trp Lys Arg Ser Ile Val Ala Tyr Phe Asn Lys His Ala 
            500                 505                 510         


Gly Lys Ser Lys Glu Glu Ala Lys Leu Ala Phe Leu Lys Leu Ile Phe 
        515                 520                 525             


Lys Trp Pro Thr Phe Gly Ser Ala Phe Phe Glu Val Lys Gln Thr Thr 
    530                 535                 540                 


Glu Pro Asn Phe Pro Glu Ile Leu Leu Ile Ala Ile Asn Lys Tyr Gly 
545                 550                 555                 560 


Val Ser Leu Ile Asp Pro Lys Thr Lys Asp Ile Leu Thr Thr His Pro 
                565                 570                 575     


Phe Thr Lys Ile Ser Asn Trp Ser Ser Gly Asn Thr Tyr Phe His Ile 
            580                 585                 590         


Thr Ile Gly Asn Leu Val Arg Gly Ser Lys Leu Leu Cys Glu Thr Ser 
        595                 600                 605             


Leu Gly Tyr Lys Met Asp Asp Leu Leu Thr Ser Tyr Ile Ser Gln Met 
    610                 615                 620                 


Leu Thr Ala Met Ser Lys Gln Arg Gly Ser Arg Ser Gly Lys 
625                 630                 635             


<210>  26
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Arg Ser Asn Phe Leu Lys Leu Lys Asn Ala Ala Thr Leu Ile Gln Arg 
1               5                   10                  15      


His Trp Arg Gly His Asn Cys Arg Lys Asn Tyr Arg Leu Gln Ala Leu 
            20                  25                  30          


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
        35                  40                  45              


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
    50                  55                  60                  


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
65                  70                  75                  80  


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
                85                  90                  95      


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
            100                 105                 110         


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
        115                 120                 125             


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
    130                 135                 140                 


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
145                 150                 155                 160 


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
                165                 170                 175     


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
            180                 185                 190         


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
        195                 200                 205             


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
    210                 215                 220                 


Glu Glu Asp Tyr Thr Arg Arg Pro Leu Lys Gln Pro Leu Leu Tyr His 
225                 230                 235                 240 


Asp Asp Glu Gly Asp Gln Leu Ala Ala Leu Ala Val Trp Ile Thr Ile 
                245                 250                 255     


Leu Arg Phe Met Gly Asp Leu Pro Glu Pro Lys Tyr His Thr Ala Met 
            260                 265                 270         


Ser Asp Gly Ser Glu Lys Ile Pro Val Met Thr Lys Ile Tyr Glu Thr 
        275                 280                 285             


Leu Gly Lys Lys Thr Tyr Lys Arg Glu Leu Gln Ala Leu Gln Gly Glu 
    290                 295                 300                 


Gly Glu Ala Gln Leu Pro Glu Gly Gln Lys Lys Ser Ser Val Arg His 
305                 310                 315                 320 


Lys Leu Val His Leu Thr Leu Lys Lys Lys Ser Lys Leu Thr Glu Glu 
                325                 330                 335     


Val Thr Lys Arg Leu His Asp Gly Glu Ser Thr Val Gln Gly Asn Ser 
            340                 345                 350         


Met Leu Glu Asp Arg Pro Thr Ser Asn Leu Glu Lys Leu His Phe Ile 
        355                 360                 365             


Ile Gly Asn Gly Ile Leu Arg Pro Ala Leu Arg Asp Glu Ile Tyr Cys 
    370                 375                 380                 


Gln Ile Ser Lys Gln Leu Thr His Asn Pro Ser Lys Ser Ser Tyr Ala 
385                 390                 395                 400 


Arg Gly Trp Ile Leu Val Ser Leu Cys Val Gly Cys Phe Ala Pro Ser 
                405                 410                 415     


Glu Lys Phe Val Lys Tyr Leu Arg Asn Phe Ile His Gly Gly Pro Pro 
            420                 425                 430         


Gly Tyr Ala Pro Tyr Cys Glu Glu Arg Leu Arg Arg Thr Phe Val Asn 
        435                 440                 445             


Gly Thr Arg Thr Gln Pro Pro Ser Trp Leu Glu Leu Gln Ala Thr Lys 
    450                 455                 460                 


Ser Lys Lys Pro Ile Met Leu Ser Lys Tyr Val Val Ala Leu Gln Asp 
465                 470                 475                 480 


Asn Pro Asn Pro Ala Gly Glu Glu Ser Gly Phe Leu Ser Phe Ala Lys 
                485                 490                 495     


Gly Asp Leu Ile Ile Leu Asp His Asp Thr Gly Glu Gln Val Met Asn 
            500                 505                 510         


Ser Gly Trp Ala Asn Gly Ile Asn Glu Arg Thr Lys Gln Arg Gly Asp 
        515                 520                 525             


Phe Pro Thr Asp Ser Val Tyr Val Met Pro Thr Val Thr Met Pro Pro 
    530                 535                 540                 


Arg Glu Ile Val Ala Leu Val Thr Met Thr Pro Asp Gln Arg Gln Asp 
545                 550                 555                 560 


Val Val Arg Leu Leu Gln Leu Arg Thr Ala Glu Pro Glu Val Arg Ala 
                565                 570                 575     


Lys Pro Tyr Thr Leu Glu Glu Phe Ser Tyr Asp Tyr Phe Arg Pro Pro 
            580                 585                 590         


Pro Lys His Thr Leu Ser Arg Val Met Val Ser Lys Ala Arg Gly Lys 
        595                 600                 605             


Asp Arg Leu Trp Ser His Thr Arg Glu Pro Leu Lys Gln Ala Leu Leu 
    610                 615                 620                 


Lys Lys Leu Leu Gly Ser Glu Glu Leu Ser Gln Glu Ala Cys Leu Ala 
625                 630                 635                 640 


Phe Ile Ala Val Leu Lys Tyr Met Gly Asp Tyr Pro Ser Lys Arg Thr 
                645                 650                 655     


Arg Ser Val Asn Glu Leu Thr Asp Gln Ile Phe Glu Gly Pro Leu Lys 
            660                 665                 670         


Ala Glu Pro Leu Lys Asp Glu Ala Tyr Val Gln Ile Leu Lys Gln Leu 
        675                 680                 685             


Thr Asp Asn His Ile Arg Tyr Ser Glu Glu Arg Gly Trp Glu Leu Leu 
    690                 695                 700                 


Trp Leu Cys Thr Gly Leu Phe Pro Pro Ser Asn Ile Leu Leu Pro His 
705                 710                 715                 720 


Val Gln Arg Phe Leu Gln Ser Arg Lys His Cys Pro Leu Ala Ile Asp 
                725                 730                 735     


Cys Leu Gln Arg Leu Gln Lys Ala Leu Arg Asn Gly Ser Arg Lys Tyr 
            740                 745                 750         


Pro Pro His Leu Val Glu Val Glu Ala Ile Gln 
        755                 760             


