                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
      UNIVERSITY OF MARYLAND BALTIMORE COUNTY
 
<120> METHODS AND COMPOSITIONS FOR MODULATING THE IMMUNE SYSTEM

<130> 701586-095060WOPT

<140> PCT/US2020/028229
<141> 2020-04-15

<150> 62/950,664
<151> 2019-12-19

<150> 62/833,877
<151> 2019-04-15

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 1515
<212> DNA
<213> Homo sapiens

<400> 1
atggatcccg ggcagcagcc gccgcctcaa ccggcccccc agggccaagg gcagccgcct       60

tcgcagcccc cgcaggggca gggcccgccg tccggacccg ggcaaccggc acccgcggcg      120

acccaggcgg cgccgcaggc accccccgcc gggcatcaga tcgtgcacgt ccgcggggac      180

tcggagaccg acctggaggc gctcttcaac gccgtcatga accccaagac ggccaacgtg      240

ccccagaccg tgcccatgag gctccggaag ctgcccgact ccttcttcaa gccgccggag      300

cccaaatccc actcccgaca ggccagtact gatgcaggca ctgcaggagc cctgactcca      360

cagcatgttc gagctcattc ctctccagct tctctgcagt tgggagctgt ttctcctggg      420

acactgaccc ccactggagt agtctctggc ccagcagcta cacccacagc tcagcatctt      480

cgacagtctt cttttgagat acctgatgat gtacctctgc cagcaggttg ggagatggca      540

aagacatctt ctggtcagag atacttctta aatcacatcg atcagacaac aacatggcag      600

gaccccagga aggccatgct gtcccagatg aacgtcacag cccccaccag tccaccagtg      660

cagcagaata tgatgaactc ggcttcaggt cctcttcctg atggatggga acaagccatg      720

actcaggatg gagaaattta ctatataaac cataagaaca agaccacctc ttggctagac      780

ccaaggcttg accctcgttt tgccatgaac cagagaatca gtcagagtgc tccagtgaaa      840

cagccaccac ccctggctcc ccagagccca cagggaggcg tcatgggtgg cagcaactcc      900

aaccagcagc aacagatgcg actgcagcaa ctgcagatgg agaaggagag gctgcggctg      960

aaacagcaag aactgcttcg gcaggcaatg cggaatatca atcccagcac agcaaattct     1020

ccaaaatgtc aggagttagc cctgcgtagc cagttaccaa cactggagca ggatggtggg     1080

actcaaaatc cagtgtcttc tcccgggatg tctcaggaat tgagaacaat gacgaccaat     1140

agctcagatc ctttccttaa cagtggcacc tatcactctc gagatgagag tacagacagt     1200

ggactaagca tgagcagcta cagtgtccct cgaaccccag atgacttcct gaacagtgtg     1260

gatgagatgg atacaggtga tactatcaac caaagcaccc tgccctcaca gcagaaccgt     1320

ttcccagact accttgaagc cattcctggg acaaatgtgg accttggaac actggaagga     1380

gatggaatga acatagaagg agaggagctg atgccaagtc tgcaggaagc tttgagttct     1440

gacatcctta atgacatgga gtctgttttg gctgccacca agctagataa agaaagcttt     1500

cttacatggt tatag                                                      1515


<210> 2
<211> 504
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met 
225                 230                 235                 240 


Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr 
                245                 250                 255     


Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg 
            260                 265                 270         


Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln 
        275                 280                 285             


Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln 
    290                 295                 300                 


Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu 
305                 310                 315                 320 


Lys Gln Gln Glu Leu Leu Arg Gln Ala Met Arg Asn Ile Asn Pro Ser 
                325                 330                 335     


Thr Ala Asn Ser Pro Lys Cys Gln Glu Leu Ala Leu Arg Ser Gln Leu 
            340                 345                 350         


Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro 
        355                 360                 365             


Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro 
    370                 375                 380                 


Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp Ser 
385                 390                 395                 400 


Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe 
                405                 410                 415     


Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser 
            420                 425                 430         


Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile 
        435                 440                 445             


Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn 
    450                 455                 460                 


Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser 
465                 470                 475                 480 


Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
                485                 490                 495     


Lys Glu Ser Phe Leu Thr Trp Leu 
            500                 


<210> 3
<211> 1203
<212> DNA
<213> Homo sapiens

<400> 3
atgaatccgg cctcggcgcc ccctccgctc ccgccgcctg ggcagcaagt gatccacgtc       60

acgcaggacc tagacacaga cctcgaagcc ctcttcaact ctgtcatgaa tccgaagcct      120

agctcgtggc ggaagaagat cctgccggag tctttcttta aggagcctga ttcgggctcg      180

cactcgcgcc agtccagcac cgactcgtcg ggcggccacc cggggcctcg actggctggg      240

ggtgcccagc atgtccgctc gcactcgtcg cccgcgtccc tgcagctggg caccggcgcg      300

ggtgctgcgg gtagccccgc gcagcagcac gcgcacctcc gccagcagtc ctacgacgtg      360

accgacgagc tgccactgcc cccgggctgg gagatgacct tcacggccac tggccagagg      420

tacttcctca atcacataga aaaaatcacc acatggcaag accctaggaa ggcgatgaat      480

cagcctctga atcatatgaa cctccaccct gccgtcagtt ccacaccagt gcctcagagg      540

tccatggcag tatcccagcc aaatctcgtg atgaatcacc aacaccagca gcagatggcc      600

cccagtaccc tgagccagca gaaccacccc actcagaacc cacccgcagg gctcatgagt      660

atgcccaatg cgctgaccac tcagcagcag cagcagcaga aactgcggct tcagagaatc      720

cagatggaga gagaaaggat tcgaatgcgc caagaggagc tcatgaggca ggaagctgcc      780

ctctgtcgac agctccccat ggaagctgag actcttgccc cagttcaggc tgctgtcaac      840

ccacccacga tgaccccaga catgagatcc atcactaata atagctcaga tcctttcctc      900

aatggagggc catatcattc gagggagcag agcactgaca gtggcctggg gttagggtgc      960

tacagtgtcc ccacaactcc ggaggacttc ctcagcaatg tggatgagat ggatacagga     1020

gaaaacgcag gacaaacacc catgaacatc aatccccaac agacccgttt ccctgatttc     1080

cttgactgtc ttccaggaac aaacgttgac ttaggaactt tggaatctga agacctgatc     1140

cccctcttca atgatgtaga gtctgctctg aacaaaagtg agccctttct aacctggctg     1200

taa                                                                   1203


<210> 4
<211> 400
<212> PRT
<213> Homo sapiens

<400> 4
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn 
            180                 185                 190         


His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn 
        195                 200                 205             


His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala 
    210                 215                 220                 


Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile 
225                 230                 235                 240 


Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg 
                245                 250                 255     


Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu 
            260                 265                 270         


Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met 
        275                 280                 285             


Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro 
    290                 295                 300                 


Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys 
305                 310                 315                 320 


Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu 
                325                 330                 335     


Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro 
            340                 345                 350         


Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn 
        355                 360                 365             


Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn 
    370                 375                 380                 


Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395                 400 


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
catcagatcg tgcacgtccg                                                   20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gctgcgaagg cggctgccct                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
cagggcccgc cgtccggacc                                                   20


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tgccccagac cgtgcccat                                                    19


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
atccgaagcc tagctcgtgg                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tgtctaggtc ctgcgtgacg                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ctctgctccc tcgaatgata                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
tctcatgtct ggggtcatcg                                                   20


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
uguggaugag auggauaca                                                    19


<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
uguauccauc ucauccaca                                                    19


<210> 15
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gacaucuucu ggucagaga                                                    19


<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ucucugacca gaagauguc                                                    19


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ggugauacua ucaaccaaa                                                    19


<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
uuugguugau aguaucacc                                                    19


<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
caauaugaau auggagauc                                                    19


<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gaucuccaua uucauauug                                                    19


<210> 21
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
acguugacuu aggaacuu                                                     18


<210> 22
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
aaguuccuaa gucaacgu                                                     18


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
agguacuucc ucaaucaca                                                    19


<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
ugugauugag gaaguaccu                                                    19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gguacuuccu caaucacau                                                    19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
augugauuga ggaaguacc                                                    19


<210> 27
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Gly Asp Ser 
1               


