                         SEQUENCE LISTING

<110>  Bar-Ilan University
       COHEN, Cyrille Joseph
       REBOH, Yishai
       MERIL, Sara
       EISENBERG, Vasyl
 
<120>  SIGLEC-BASED CHIMERIC POLYPEPTIDES AND USES THEREOF

<130>  82417

<150>  62/834,995
<151>  2019-04-17

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210>  2
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG-like V domain of Siglec7

<400>  2

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


<210>  3
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG-like C2 domain of Siglec 7 (domain 2)

<400>  3

His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Phe 
1               5                   10                  15      


Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
            20                  25                  30          


Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro Ser 
        35                  40                  45              


Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His His 
    50                  55                  60                  


Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val Thr 
65                  70                  75                  80  


Thr Asn Arg Thr Ile Gln Leu Asn Val Ser 
                85                  90  


<210>  4
<211>  91
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG-like C2 domain of Siglec 7 (domain 3)

<400>  4

Glu Gly Thr Ala Ser Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val 
1               5                   10                  15      


Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro 
            20                  25                  30          


Pro Ala Arg Leu Ser Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser 
        35                  40                  45              


Gln Pro Ser Asn Pro Leu Val Leu Glu Leu Gln Val His Leu Gly Asp 
    50                  55                  60                  


Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His 
65                  70                  75                  80  


Val Ser Leu Asn Leu Ser Leu Gln Gln Glu Tyr 
                85                  90      


<210>  5
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Ile Leu Asn His Phe Ile Gly Phe Pro Thr Phe Leu Gly Leu Gly 
                405                 410                 415     


Phe Glu Phe Leu Leu Asn Leu Arg Asp Leu Cys Cys His Pro Asp Ser 
            420                 425                 430         


Glu Phe Tyr Val Tyr His Phe Ser His Phe Arg Leu Ile Lys Asn Ile 
        435                 440                 445             


Ala Gly Glu Ile Val Trp Ser Leu Glu Gly Lys Ile Leu Trp Leu Leu 
    450                 455                 460                 


Asp Val Ser Asp Phe Phe His Trp Phe Phe Leu Ile Cys Val Gly 
465                 470                 475                 


<210>  6
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG-like V domain of Siglec9

<400>  6

Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
            20                  25                  30          


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
        35                  40                  45              


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
    50                  55                  60                  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
65                  70                  75                  80  


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
                85                  90                  95      


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
            100                 105                 110         


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125     


<210>  7
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG-like C2 domain of Siglec 9 (domain 2)

<400>  7

His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro 
1               5                   10                  15      


Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
            20                  25                  30          


Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser 
        35                  40                  45              


Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His 
    50                  55                  60                  


Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr 
65                  70                  75                  80  


Thr Asn Lys Thr Val His Leu Asn Val Ser 
                85                  90  


<210>  8
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG-like C2 domain of Siglec 9 (domain 3)

<400>  8

Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser Leu Ser Leu 
1               5                   10                  15      


Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp Ala Val Asp 
            20                  25                  30          


Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly Leu Thr Leu 
        35                  40                  45              


Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu Pro Trp Val 
    50                  55                  60                  


His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu 
65                  70                  75                  80  


Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu Gln Ser Lys Ala 
                85                  90                  95  


<210>  9
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S7TM28 construct aa sequence

<400>  9

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly 
    210                 215                 220                 


Ala Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser 
                245                 250                 255     


Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser 
        275                 280                 285             


Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro 
    290                 295                 300                 


Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu 
                325                 330                 335     


Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val 
            340                 345                 350         


Leu Leu Ala Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    370                 375                 380                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
385                 390                 395                 400 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                405                 410                 415     


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
            420                 425                 430         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        435                 440                 445             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    450                 455                 460                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
465                 470                 475                 480 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                485                 490                 495     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            500                 505                 510         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        515                 520                 525             


His Met Gln Ala Leu Pro Pro Arg 
    530                 535     


<210>  10
<211>  530
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S7TMSG construct aa sequence

<400>  10

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly 
    210                 215                 220                 


Ala Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser 
                245                 250                 255     


Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser 
        275                 280                 285             


Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro 
    290                 295                 300                 


Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu 
                325                 330                 335     


Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val 
            340                 345                 350         


Leu Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu 
        355                 360                 365             


Ser Phe Cys Val Ile Phe Ile Val Val Arg Ser Lys Arg Ser Arg Leu 
    370                 375                 380                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
385                 390                 395                 400 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                405                 410                 415     


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             


Pro Arg 
    530 


<210>  11
<211>  528
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S7HINGE construct aa sequence

<400>  11

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly 
    210                 215                 220                 


Ala Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser 
                245                 250                 255     


Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser 
        275                 280                 285             


Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro 
    290                 295                 300                 


Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu 
                325                 330                 335     


Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Phe Trp Val Leu 
            340                 345                 350         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        355                 360                 365             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    370                 375                 380                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
385                 390                 395                 400 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                405                 410                 415     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            420                 425                 430         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        435                 440                 445             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    450                 455                 460                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


<210>  12
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S9TM28 construct aa sequence

<400>  12

Met Ser Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala 
1               5                   10                  15      


Glu Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val 
            20                  25                  30          


Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser 
        35                  40                  45              


His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg 
    50                  55                  60                  


Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro 
65                  70                  75                  80  


Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly 
                85                  90                  95      


Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg 
            100                 105                 110         


Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys 
        115                 120                 125             


Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr 
    130                 135                 140                 


His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro 
145                 150                 155                 160 


Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
                165                 170                 175     


Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser 
            180                 185                 190         


Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His 
        195                 200                 205             


Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr 
    210                 215                 220                 


Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu 
225                 230                 235                 240 


Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly 
                245                 250                 255     


Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val 
            260                 265                 270         


Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu 
        275                 280                 285             


Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly 
    290                 295                 300                 


Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val 
                325                 330                 335     


Ser Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Phe Trp Val 
            340                 345                 350         


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        355                 360                 365             


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    370                 375                 380                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
385                 390                 395                 400 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                405                 410                 415     


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             


Arg 
    


<210>  13
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S9TMSG construct aa sequence

<400>  13

Met Ser Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala 
1               5                   10                  15      


Glu Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val 
            20                  25                  30          


Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser 
        35                  40                  45              


His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg 
    50                  55                  60                  


Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro 
65                  70                  75                  80  


Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly 
                85                  90                  95      


Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg 
            100                 105                 110         


Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys 
        115                 120                 125             


Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr 
    130                 135                 140                 


His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro 
145                 150                 155                 160 


Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
                165                 170                 175     


Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser 
            180                 185                 190         


Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His 
        195                 200                 205             


Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr 
    210                 215                 220                 


Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu 
225                 230                 235                 240 


Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly 
                245                 250                 255     


Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val 
            260                 265                 270         


Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu 
        275                 280                 285             


Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly 
    290                 295                 300                 


Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val 
                325                 330                 335     


Ser Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly 
            340                 345                 350         


Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe 
        355                 360                 365             


Val Val Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    370                 375                 380                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
385                 390                 395                 400 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
                405                 410                 415     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            420                 425                 430         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        435                 440                 445             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    450                 455                 460                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
465                 470                 475                 480 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                485                 490                 495     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            500                 505                 510         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 


<210>  14
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S9-PSKP construct aa sequence

<400>  14

Met Ser Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala 
1               5                   10                  15      


Glu Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val 
            20                  25                  30          


Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser 
        35                  40                  45              


His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg 
    50                  55                  60                  


Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro 
65                  70                  75                  80  


Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly 
                85                  90                  95      


Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg 
            100                 105                 110         


Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys 
        115                 120                 125             


Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr 
    130                 135                 140                 


His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro 
145                 150                 155                 160 


Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
                165                 170                 175     


Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser 
            180                 185                 190         


Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His 
        195                 200                 205             


Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr 
    210                 215                 220                 


Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu 
225                 230                 235                 240 


Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly 
                245                 250                 255     


Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val 
            260                 265                 270         


Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu 
        275                 280                 285             


Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly 
    290                 295                 300                 


Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val 
                325                 330                 335     


Ser Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Pro Ser Lys 
            340                 345                 350         


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        355                 360                 365             


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    370                 375                 380                 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
385                 390                 395                 400 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                405                 410                 415     


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            420                 425                 430         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        435                 440                 445             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    450                 455                 460                 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
465                 470                 475                 480 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                485                 490                 495     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            500                 505                 510         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        515                 520                 525             


Ala Leu Pro Pro Arg 
    530             


<210>  15
<211>  341
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S7D1 construct aa sequence

<400>  15

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Ala 
145                 150                 155                 160 


Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
                165                 170                 175     


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            180                 185                 190         


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        195                 200                 205             


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    210                 215                 220                 


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
225                 230                 235                 240 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                245                 250                 255     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            260                 265                 270         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        275                 280                 285             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    290                 295                 300                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
305                 310                 315                 320 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                325                 330                 335     


Ala Leu Pro Pro Arg 
            340     


<210>  16
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S7D1+2 construct aa sequence

<400>  16

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly 
    210                 215                 220                 


Ala Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Thr Gly Lys Met Arg 
                245                 250                 255     


Pro Val Ser Gly Val Leu Leu Ala Ser Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
    290                 295                 300                 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
305                 310                 315                 320 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  17
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S7D1+3 construct aa sequence

<400>  17

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr Tyr Pro Pro Gln Asn Leu Thr Val Thr Val Phe Gln 
145                 150                 155                 160 


Gly Glu Gly Thr Ala Ser Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser 
                165                 170                 175     


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp Ser Asn 
            180                 185                 190         


Pro Pro Ala Arg Leu Ser Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro 
        195                 200                 205             


Ser Gln Pro Ser Asn Pro Leu Val Leu Glu Leu Gln Val His Leu Gly 
    210                 215                 220                 


Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln 
225                 230                 235                 240 


His Val Ser Leu Asn Leu Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met 
                245                 250                 255     


Arg Pro Val Ser Gly Val Leu Leu Ala Ser Phe Trp Val Leu Val Val 
            260                 265                 270         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        275                 280                 285             


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
    290                 295                 300                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
305                 310                 315                 320 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445     


<210>  18
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S728 CSR construct aa sequence

<400>  18

Met Ser Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg 
1               5                   10                  15      


Val Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln 
            20                  25                  30          


Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly 
    210                 215                 220                 


Ala Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser 
                245                 250                 255     


Thr Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser 
        275                 280                 285             


Trp Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro 
    290                 295                 300                 


Leu Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu 
                325                 330                 335     


Ser Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val 
            340                 345                 350         


Leu Leu Ala Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        355                 360                 365             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    370                 375                 380                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
385                 390                 395                 400 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                405                 410                 415     


Arg Asp Phe Ala Ala Tyr Arg Ser 
            420                 


<210>  19
<211>  417
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S928 CSR construct aa sequence

<400>  19

Met Ser Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala 
1               5                   10                  15      


Glu Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val 
            20                  25                  30          


Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser 
        35                  40                  45              


His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg 
    50                  55                  60                  


Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro 
65                  70                  75                  80  


Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly 
                85                  90                  95      


Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg 
            100                 105                 110         


Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys 
        115                 120                 125             


Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr 
    130                 135                 140                 


His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro 
145                 150                 155                 160 


Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
                165                 170                 175     


Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser 
            180                 185                 190         


Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His 
        195                 200                 205             


Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr 
    210                 215                 220                 


Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu 
225                 230                 235                 240 


Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly 
                245                 250                 255     


Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val 
            260                 265                 270         


Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu 
        275                 280                 285             


Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly 
    290                 295                 300                 


Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr 
305                 310                 315                 320 


Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val 
                325                 330                 335     


Ser Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Phe Trp Val 
            340                 345                 350         


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        355                 360                 365             


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    370                 375                 380                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
385                 390                 395                 400 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                405                 410                 415     


Ser 
    


<210>  20
<211>  421
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S928_B CSR construct aa sequence

<400>  20

Met Ser Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Gln Thr Ser Lys Leu Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Ser His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Arg Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Ser Ile Lys Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Pro Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu Asp Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln Asp His Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly 
    210                 215                 220                 


Ala Ser Val Thr Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser 
                245                 250                 255     


Thr Val Leu Gly Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala 
        275                 280                 285             


Arg Leu Ser Leu Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro 
    290                 295                 300                 


Ser Asn Pro Gly Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala 
305                 310                 315                 320 


Ala Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val 
                325                 330                 335     


Tyr Leu Asn Val Ser Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln 
            340                 345                 350         


Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        355                 360                 365             


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    370                 375                 380                 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
385                 390                 395                 400 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                405                 410                 415     


Ala Ala Tyr Arg Ser 
            420     


<210>  21
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S928_C CSR construct aa sequence

<400>  21

Met Ser Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Gln Thr Ser Lys Leu Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Ser His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Arg Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Ser Ile Lys Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Pro Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu Asp Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln Asp His Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly 
    210                 215                 220                 


Ala Ser Val Thr Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser 
                245                 250                 255     


Thr Val Leu Gly Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala 
        275                 280                 285             


Arg Leu Ser Leu Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro 
    290                 295                 300                 


Ser Asn Pro Gly Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala 
305                 310                 315                 320 


Ala Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val 
                325                 330                 335     


Tyr Leu Asn Val Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
            340                 345                 350         


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
        355                 360                 365             


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
    370                 375                 380                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
385                 390                 395                 400 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                405                 410                 415     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            420                 425                 430         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        435                 440                 445             


<210>  22
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S928_F CSR construct aa sequence

<400>  22

Met Ser Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Gln Thr Ser Lys Leu Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Ser His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Arg Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Ser Ile Lys Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Pro Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu Asp Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln Asp His Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly 
    210                 215                 220                 


Ala Ser Val Thr Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser 
                245                 250                 255     


Thr Val Leu Gly Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala 
        275                 280                 285             


Arg Leu Ser Leu Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro 
    290                 295                 300                 


Ser Asn Pro Gly Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala 
305                 310                 315                 320 


Ala Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val 
                325                 330                 335     


Tyr Leu Asn Val Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
            340                 345                 350         


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
        355                 360                 365             


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
    370                 375                 380                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
385                 390                 395                 400 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                405                 410                 415     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            420                 425                 430         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        435                 440                 445             


Leu 
    


<210>  23
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S928_G CSR construct aa sequence

<400>  23

Met Ser Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Gln Thr Ser Lys Leu Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Ser His Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Glu Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Ala Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe 
                85                  90                  95      


His Leu Leu Gly Asp Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Arg Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys 
        115                 120                 125             


Gly Ser Ile Lys Trp Asn Tyr Lys His His Arg Leu Ser Val Asn Val 
    130                 135                 140                 


Thr Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu 
145                 150                 155                 160 


Ser Gly Cys Pro Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu 
                165                 170                 175     


Gln Gly Thr Pro Pro Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro 
            180                 185                 190         


Leu Asp Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln 
        195                 200                 205             


Pro Gln Asp His Gly Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly 
    210                 215                 220                 


Ala Ser Val Thr Thr Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro 
225                 230                 235                 240 


Pro Gln Asn Leu Thr Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser 
                245                 250                 255     


Thr Val Leu Gly Asn Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser 
            260                 265                 270         


Leu Arg Leu Val Cys Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala 
        275                 280                 285             


Arg Leu Ser Leu Ser Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro 
    290                 295                 300                 


Ser Asn Pro Gly Val Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala 
305                 310                 315                 320 


Ala Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val 
                325                 330                 335     


Tyr Leu Asn Val Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            340                 345                 350         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        355                 360                 365             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    370                 375                 380                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
385                 390                 395                 400 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                405                 410                 415     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            420                 425                 430         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        435                 440                 445             


Glu Gly Gly Cys Glu Leu 
    450                 


<210>  24
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3 zeta cytosplasmic

<400>  24

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  25
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 cytosplasmic

<400>  25

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  26
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB cytosplasmic

<400>  26

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  27
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 TransMembrane

<400>  27

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  28
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 Hinge

<400>  28

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  29
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGLEC7 TransMembrane

<400>  29

Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe 
1               5                   10                  15      


Cys Val Ile Phe Ile Val Val 
            20              


<210>  30
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGLEC7 Hinge in S7-hinge construct

<400>  30

Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro 
1               5                   10      


<210>  31
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGLEC7 Hinge in s7TM28 and s7TMSG constructs

<400>  31

Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
1               5                   10                  15      


Leu 
    


<210>  32
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGLEC9 TransMembrane

<400>  32

Val Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys 
1               5                   10                  15      


Val Ile Phe Val Val Val 
            20          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGLEC9 Hinge

<400>  33

Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly 
1               5                   10          


<210>  34
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD8a Hinge

<400>  34

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45          


<210>  35
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD8a TM

<400>  35

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  36
<211>  1608
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S7TM28 construct nt sequence

<400>  36
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacccacagg cccaacatcc ttatccccgg taccctggag      480

tctggctgct tccagaatct gacctgctct gtgccctggg cctgtgagca ggggacgccc      540

cctatgatct cctggatggg gacctctgtg tcccccctgc acccctccac cacccgctcc      600

tcagtgctca ccctcatccc acagccccag caccacggca ccagcctcac ctgtcaggtg      660

accttgcctg gggccggcgt gaccacgaac aggaccatcc aactcaatgt gtcctaccct      720

cctcagaact tgactgtgac tgtcttccaa ggagaaggca cagcatccac agctctgggg      780

aacagctcat ctctttcagt cctagagggc cagtctctgc gcttggtctg tgctgttgac      840

agcaatcccc ctgccaggct gagctggacc tggaggagtc tgaccctgta cccctcacag      900

ccctcaaacc ctctggtact ggagctgcaa gtgcacctgg gggatgaagg ggaattcacc      960

tgtcgagctc agaactctct gggttcccag cacgtttccc tgaacctctc cctgcaacag     1020

gagtacacag gcaaaatgag gcctgtatca ggagtgttgc tggcgagctt ttgggtgctg     1080

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1140

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1200

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1260

gcctatcgct ccagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1320

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1380

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1440

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1500

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1560

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgc                  1608


<210>  37
<211>  1590
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S7TMSG construct nt sequence

<400>  37
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacccacagg cccaacatcc ttatccccgg taccctggag      480

tctggctgct tccagaatct gacctgctct gtgccctggg cctgtgagca ggggacgccc      540

cctatgatct cctggatggg gacctctgtg tcccccctgc acccctccac cacccgctcc      600

tcagtgctca ccctcatccc acagccccag caccacggca ccagcctcac ctgtcaggtg      660

accttgcctg gggccggcgt gaccacgaac aggaccatcc aactcaatgt gtcctaccct      720

cctcagaact tgactgtgac tgtcttccaa ggagaaggca cagcatccac agctctgggg      780

aacagctcat ctctttcagt cctagagggc cagtctctgc gcttggtctg tgctgttgac      840

agcaatcccc ctgccaggct gagctggacc tggaggagtc tgaccctgta cccctcacag      900

ccctcaaacc ctctggtact ggagctgcaa gtgcacctgg gggatgaagg ggaattcacc      960

tgtcgagctc agaactctct gggttcccag cacgtttccc tgaacctctc cctgcaacag     1020

gagtacacag gcaaaatgag gcctgtatca ggagtgttgc tgggggcggt cgggggagct     1080

ggagccacag ccctggtctt cctctccttc tgtgtcatct tcattgtagt gaggagtaag     1140

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc     1200

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg     1260

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1320

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1380

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1440

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1500

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1560

gcccttcaca tgcaggccct gccccctcgc                                      1590


<210>  38
<211>  1584
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S7HINGE construct nt sequence

<400>  38
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacccacagg cccaacatcc ttatccccgg taccctggag      480

tctggctgct tccagaatct gacctgctct gtgccctggg cctgtgagca ggggacgccc      540

cctatgatct cctggatggg gacctctgtg tcccccctgc acccctccac cacccgctcc      600

tcagtgctca ccctcatccc acagccccag caccacggca ccagcctcac ctgtcaggtg      660

accttgcctg gggccggcgt gaccacgaac aggaccatcc aactcaatgt gtcctaccct      720

cctcagaact tgactgtgac tgtcttccaa ggagaaggca cagcatccac agctctgggg      780

aacagctcat ctctttcagt cctagagggc cagtctctgc gcttggtctg tgctgttgac      840

agcaatcccc ctgccaggct gagctggacc tggaggagtc tgaccctgta cccctcacag      900

ccctcaaacc ctctggtact ggagctgcaa gtgcacctgg gggatgaagg ggaattcacc      960

tgtcgagctc agaactctct gggttcccag cacgtttccc tgaacctctc cctgcaacag     1020

gagtacacag gcaaaatgag gcctttttgg gtgctggtgg tggttggtgg agtcctggct     1080

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1140

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1200

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1260

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1320

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1380

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1440

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1500

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1560

cacatgcagg ccctgccccc tcgc                                            1584


<210>  39
<211>  1587
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S9TM28 construct nt sequence

<400>  39
atgtcgctgc tgctgctgct gcccctgctc tgggggaggg agagggcgga aggacagaca       60

agtaaactgc tgacgatgca gagttccgtg acggtgcagg aaggcctgtg tgtccatgtg      120

ccctgctcct tctcctaccc ctcgcatggc tggatttacc ctggcccagt agttcatggc      180

tactggttcc gggaaggggc caatacagac caggatgctc cagtggccac aaacaaccca      240

gctcgggcag tgtgggagga gactcgggac cgattccacc tccttgggga cccacatacc      300

aagaattgca ccctgagcat cagagatgcc agaagaagtg atgcggggag atacttcttt      360

cgtatggaga aaggaagtat aaaatggaat tataaacatc accggctctc tgtgaatgtg      420

acagccttga cccacaggcc caacatcctc atcccaggca ccctggagtc cggctgcccc      480

cagaatctga cctgctctgt gccctgggcc tgtgagcagg ggacaccccc tatgatctcc      540

tggataggga cctccgtgtc ccccctggac ccctccacca cccgctcctc ggtgctcacc      600

ctcatcccac agccccagga ccatggcacc agcctcacct gtcaggtgac cttccctggg      660

gccagcgtga ccacgaacaa gaccgtccat ctcaacgtgt cctacccgcc tcagaacttg      720

accatgactg tcttccaagg agacggcaca gtatccacag tcttgggaaa tggctcatct      780

ctgtcactcc cagagggcca gtctctgcgc ctggtctgtg cagttgatgc agttgacagc      840

aatccccctg ccaggctgag cctgagctgg agaggcctga ccctgtgccc ctcacagccc      900

tcaaacccgg gggtgctgga gctgccttgg gtgcacctga gggatgcagc tgaattcacc      960

tgcagagctc agaaccctct cggctctcag caggtctacc tgaacgtctc cctgcagagc     1020

aaagccacat caggagtgac tcaggggttt tgggtgctgg tggtggttgg tggagtcctg     1080

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg     1140

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc     1200

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1260

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1320

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1380

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1440

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1500

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1560

cttcacatgc aggccctgcc ccctcgc                                         1587


<210>  40
<211>  1572
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S9TMSG construct nt sequence

<400>  40
atgtcgctgc tgctgctgct gcccctgctc tgggggaggg agagggcgga aggacagaca       60

agtaaactgc tgacgatgca gagttccgtg acggtgcagg aaggcctgtg tgtccatgtg      120

ccctgctcct tctcctaccc ctcgcatggc tggatttacc ctggcccagt agttcatggc      180

tactggttcc gggaaggggc caatacagac caggatgctc cagtggccac aaacaaccca      240

gctcgggcag tgtgggagga gactcgggac cgattccacc tccttgggga cccacatacc      300

aagaattgca ccctgagcat cagagatgcc agaagaagtg atgcggggag atacttcttt      360

cgtatggaga aaggaagtat aaaatggaat tataaacatc accggctctc tgtgaatgtg      420

acagccttga cccacaggcc caacatcctc atcccaggca ccctggagtc cggctgcccc      480

cagaatctga cctgctctgt gccctgggcc tgtgagcagg ggacaccccc tatgatctcc      540

tggataggga cctccgtgtc ccccctggac ccctccacca cccgctcctc ggtgctcacc      600

ctcatcccac agccccagga ccatggcacc agcctcacct gtcaggtgac cttccctggg      660

gccagcgtga ccacgaacaa gaccgtccat ctcaacgtgt cctacccgcc tcagaacttg      720

accatgactg tcttccaagg agacggcaca gtatccacag tcttgggaaa tggctcatct      780

ctgtcactcc cagagggcca gtctctgcgc ctggtctgtg cagttgatgc agttgacagc      840

aatccccctg ccaggctgag cctgagctgg agaggcctga ccctgtgccc ctcacagccc      900

tcaaacccgg gggtgctgga gctgccttgg gtgcacctga gggatgcagc tgaattcacc      960

tgcagagctc agaaccctct cggctctcag caggtctacc tgaacgtctc cctgcagagc     1020

aaagccacat caggagtgac tcagggggtg gtcgggggag ctggagccac agccctggtc     1080

ttcctgtcct tctgcgtcat cttcgttgta gtgaggagta agaggagcag gctcctgcac     1140

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1200

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1260

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1320

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1380

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1440

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1500

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1560

ctgccccctc gc                                                         1572


<210>  41
<211>  1599
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S9-PSKP construct nt sequence

<400>  41
atgtcgctgc tgctgctgct gcccctgctc tgggggaggg agagggcgga aggacagaca       60

agtaaactgc tgacgatgca gagttccgtg acggtgcagg aaggcctgtg tgtccatgtg      120

ccctgctcct tctcctaccc ctcgcatggc tggatttacc ctggcccagt agttcatggc      180

tactggttcc gggaaggggc caatacagac caggatgctc cagtggccac aaacaaccca      240

gctcgggcag tgtgggagga gactcgggac cgattccacc tccttgggga cccacatacc      300

aagaattgca ccctgagcat cagagatgcc agaagaagtg atgcggggag atacttcttt      360

cgtatggaga aaggaagtat aaaatggaat tataaacatc accggctctc tgtgaatgtg      420

acagccttga cccacaggcc caacatcctc atcccaggca ccctggagtc cggctgcccc      480

cagaatctga cctgctctgt gccctgggcc tgtgagcagg ggacaccccc tatgatctcc      540

tggataggga cctccgtgtc ccccctggac ccctccacca cccgctcctc ggtgctcacc      600

ctcatcccac agccccagga ccatggcacc agcctcacct gtcaggtgac cttccctggg      660

gccagcgtga ccacgaacaa gaccgtccat ctcaacgtgt cctacccgcc tcagaacttg      720

accatgactg tcttccaagg agacggcaca gtatccacag tcttgggaaa tggctcatct      780

ctgtcactcc cagagggcca gtctctgcgc ctggtctgtg cagttgatgc agttgacagc      840

aatccccctg ccaggctgag cctgagctgg agaggcctga ccctgtgccc ctcacagccc      900

tcaaacccgg gggtgctgga gctgccttgg gtgcacctga gggatgcagc tgaattcacc      960

tgcagagctc agaaccctct cggctctcag caggtctacc tgaacgtctc cctgcagagc     1020

aaagccacat caggagtgac tcaggggcct tctaagccct tttgggtgct ggtggtggtt     1080

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg     1140

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     1200

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc     1260

tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1320

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1380

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1440

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1500

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1560

acctacgacg cccttcacat gcaggccctg ccccctcgc                            1599


<210>  42
<211>  1023
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S7D1 construct nt sequence

<400>  42
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacaggcaaa atgaggcctg tatcaggagt gttgctggcg      480

agcttttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca      540

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac      600

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca      660

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc      720

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      780

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg      840

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac      900

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag      960

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1020

cgc                                                                   1023


<210>  43
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S7D1+2 construct nt sequence

<400>  43
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacccacagg cccaacatcc ttatccccgg taccctggag      480

tctggctgct tccagaatct gacctgctct gtgccctggg cctgtgagca ggggacgccc      540

cctatgatct cctggatggg gacctctgtg tcccccctgc acccctccac cacccgctcc      600

tcagtgctca ccctcatccc acagccccag caccacggca ccagcctcac ctgtcaggtg      660

accttgcctg gggccggcgt gaccacgaac aggaccatcc aactcaatgt gtcctaccct      720

cctcagaact tgactgtgac tgtcttccaa ggcacaggca aaatgaggcc tgtatcagga      780

gtgttgctgg cgagcttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg      900

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag      960

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc     1020

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1080

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1140

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1200

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1260

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1320

gccctgcccc ctcgc                                                      1335


<210>  44
<211>  1338
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S7D1+3 construct nt sequence

<400>  44
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacctaccct cctcagaact tgactgtgac tgtcttccaa      480

ggagaaggca cagcatccac agctctgggg aacagctcat ctctttcagt cctagagggc      540

cagtctctgc gcttggtctg tgctgttgac agcaatcccc ctgccaggct gagctggacc      600

tggaggagtc tgaccctgta cccctcacag ccctcaaacc ctctggtact ggagctgcaa      660

gtgcacctgg gggatgaagg ggaattcacc tgtcgagctc agaactctct gggttcccag      720

cacgtttccc tgaacctctc cctgcaacag gagtacacag gcaaaatgag gcctgtatca      780

ggagtgttgc tggcgagctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      840

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      900

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      960

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1020

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1080

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1140

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1200

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1260

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1320

caggccctgc cccctcgc                                                   1338


<210>  45
<211>  1272
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S728 CSR construct nt sequence

<400>  45
atgtcgctgc tgctgctgct gctgcccctg ctctggggga gggagagggt ggaaggacag       60

aagagtaacc ggaaggatta ctcgctgacg atgcagagtt ccgtgaccgt gcaagagggc      120

atgtgtgtcc atgtgcgctg ctccttctcc tacccagtgg acagccagac tgactctgac      180

ccagttcatg gctactggtt ccgggcaggg aatgatataa gctggaaggc tccagtggcc      240

acaaacaacc cagcttgggc agtgcaggag gaaactcggg accgattcca cctccttggg      300

gacccacaga ccaaaaattg caccctgagc atcagagatg ccagaatgag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaaat ataaaatgga attataaata tgaccagctc      420

tctgtgaacg tgacagcctt gacccacagg cccaacatcc ttatccccgg taccctggag      480

tctggctgct tccagaatct gacctgctct gtgccctggg cctgtgagca ggggacgccc      540

cctatgatct cctggatggg gacctctgtg tcccccctgc acccctccac cacccgctcc      600

tcagtgctca ccctcatccc acagccccag caccacggca ccagcctcac ctgtcaggtg      660

accttgcctg gggccggcgt gaccacgaac aggaccatcc aactcaatgt gtcctaccct      720

cctcagaact tgactgtgac tgtcttccaa ggagaaggca cagcatccac agctctgggg      780

aacagctcat ctctttcagt cctagagggc cagtctctgc gcttggtctg tgctgttgac      840

agcaatcccc ctgccaggct gagctggacc tggaggagtc tgaccctgta cccctcacag      900

ccctcaaacc ctctggtact ggagctgcaa gtgcacctgg gggatgaagg ggaattcacc      960

tgtcgagctc agaactctct gggttcccag cacgtttccc tgaacctctc cctgcaacag     1020

gagtacacag gcaaaatgag gcctgtatca ggagtgttgc tggcgagctt ttgggtgctg     1080

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1140

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1200

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1260

gcctatcgct cc                                                         1272


<210>  46
<211>  1251
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S928 CSR construct nt sequence

<400>  46
atgtcgctgc tgctgctgct gcccctgctc tgggggaggg agagggcgga aggacagaca       60

agtaaactgc tgacgatgca gagttccgtg acggtgcagg aaggcctgtg tgtccatgtg      120

ccctgctcct tctcctaccc ctcgcatggc tggatttacc ctggcccagt agttcatggc      180

tactggttcc gggaaggggc caatacagac caggatgctc cagtggccac aaacaaccca      240

gctcgggcag tgtgggagga gactcgggac cgattccacc tccttgggga cccacatacc      300

aagaattgca ccctgagcat cagagatgcc agaagaagtg atgcggggag atacttcttt      360

cgtatggaga aaggaagtat aaaatggaat tataaacatc accggctctc tgtgaatgtg      420

acagccttga cccacaggcc caacatcctc atcccaggca ccctggagtc cggctgcccc      480

cagaatctga cctgctctgt gccctgggcc tgtgagcagg ggacaccccc tatgatctcc      540

tggataggga cctccgtgtc ccccctggac ccctccacca cccgctcctc ggtgctcacc      600

ctcatcccac agccccagga ccatggcacc agcctcacct gtcaggtgac cttccctggg      660

gccagcgtga ccacgaacaa gaccgtccat ctcaacgtgt cctacccgcc tcagaacttg      720

accatgactg tcttccaagg agacggcaca gtatccacag tcttgggaaa tggctcatct      780

ctgtcactcc cagagggcca gtctctgcgc ctggtctgtg cagttgatgc agttgacagc      840

aatccccctg ccaggctgag cctgagctgg agaggcctga ccctgtgccc ctcacagccc      900

tcaaacccgg gggtgctgga gctgccttgg gtgcacctga gggatgcagc tgaattcacc      960

tgcagagctc agaaccctct cggctctcag caggtctacc tgaacgtctc cctgcagagc     1020

aaagccacat caggagtgac tcaggggttt tgggtgctgg tggtggttgg tggagtcctg     1080

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg     1140

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc     1200

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc c              1251


<210>  47
<211>  1263
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S928_B CSR construct nt sequence

<400>  47
atgtccgcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc       60

aggccacaga caagtaaact gctgacgatg cagagttccg tgacggtgca ggaaggcctg      120

tgtgtccatg tgccctgctc cttctcctac ccctcgcatg gctggattta ccctggccca      180

gtagttcatg gctactggtt ccgggaaggg gccaatacag accaggatgc tccagtggcc      240

acaaacaacc cagctcgggc agtgtgggag gagactcggg accgattcca cctccttggg      300

gacccacata ccaagaattg caccctgagc atcagagatg ccagaagaag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaagt ataaaatgga attataaaca tcaccggctc      420

tctgtgaatg tgacagcctt gacccacagg cccaacatcc tcatcccagg caccctggag      480

tccggctgcc cccagaatct gacctgctct gtgccctggg cctgtgagca ggggacaccc      540

cctatgatct cctggatagg gacctccgtg tcccccctgg acccctccac cacccgctcc      600

tcggtgctca ccctcatccc acagccccag gaccatggca ccagcctcac ctgtcaggtg      660

accttccctg gggccagcgt gaccacgaac aagaccgtcc atctcaacgt gtcctacccg      720

cctcagaact tgaccatgac tgtcttccaa ggagacggca cagtatccac agtcttggga      780

aatggctcat ctctgtcact cccagagggc cagtctctgc gcctggtctg tgcagttgat      840

gcagttgaca gcaatccccc tgccaggctg agcctgagct ggagaggcct gaccctgtgc      900

ccctcacagc cctcaaaccc gggggtgctg gagctgcctt gggtgcacct gagggatgca      960

gctgaattca cctgcagagc tcagaaccct ctcggctctc agcaggtcta cctgaacgtc     1020

tccctgcaga gcaaagccac atcaggagtg actcaggggt tttgggtgct ggtggtggtt     1080

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg     1140

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     1200

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc     1260

tcc                                                                   1263


<210>  48
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S928_C CSR construct nt sequence

<400>  48
atgtccgcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc       60

aggccacaga caagtaaact gctgacgatg cagagttccg tgacggtgca ggaaggcctg      120

tgtgtccatg tgccctgctc cttctcctac ccctcgcatg gctggattta ccctggccca      180

gtagttcatg gctactggtt ccgggaaggg gccaatacag accaggatgc tccagtggcc      240

acaaacaacc cagctcgggc agtgtgggag gagactcggg accgattcca cctccttggg      300

gacccacata ccaagaattg caccctgagc atcagagatg ccagaagaag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaagt ataaaatgga attataaaca tcaccggctc      420

tctgtgaatg tgacagcctt gacccacagg cccaacatcc tcatcccagg caccctggag      480

tccggctgcc cccagaatct gacctgctct gtgccctggg cctgtgagca ggggacaccc      540

cctatgatct cctggatagg gacctccgtg tcccccctgg acccctccac cacccgctcc      600

tcggtgctca ccctcatccc acagccccag gaccatggca ccagcctcac ctgtcaggtg      660

accttccctg gggccagcgt gaccacgaac aagaccgtcc atctcaacgt gtcctacccg      720

cctcagaact tgaccatgac tgtcttccaa ggagacggca cagtatccac agtcttggga      780

aatggctcat ctctgtcact cccagagggc cagtctctgc gcctggtctg tgcagttgat      840

gcagttgaca gcaatccccc tgccaggctg agcctgagct ggagaggcct gaccctgtgc      900

ccctcacagc cctcaaaccc gggggtgctg gagctgcctt gggtgcacct gagggatgca      960

gctgaattca cctgcagagc tcagaaccct ctcggctctc agcaggtcta cctgaacgtc     1020

tccatcgaag tgatgtatcc acccccttac ctggataacg agaagagcaa tggcaccatc     1080

atccacgtga agggcaagca cctgtgccct tctccactgt tccccggccc tagcaagccc     1140

ttttgggtgc tggtggtggt gggaggcgtg ctggcctgtt attctctgct ggtgacagtg     1200

gccttcatca tcttttgggt gaggagcaag cggagccggc tgctgcacag cgactacatg     1260

aacatgaccc caagacggcc cggccccaca agaaagcact atcagccata cgcaccacca     1320

agggacttcg cagcctatag atcc                                            1344


<210>  49
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S928_F CSR construct nt sequence

<400>  49
atgtccgcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc       60

aggccacaga caagtaaact gctgacgatg cagagttccg tgacggtgca ggaaggcctg      120

tgtgtccatg tgccctgctc cttctcctac ccctcgcatg gctggattta ccctggccca      180

gtagttcatg gctactggtt ccgggaaggg gccaatacag accaggatgc tccagtggcc      240

acaaacaacc cagctcgggc agtgtgggag gagactcggg accgattcca cctccttggg      300

gacccacata ccaagaattg caccctgagc atcagagatg ccagaagaag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaagt ataaaatgga attataaaca tcaccggctc      420

tctgtgaatg tgacagcctt gacccacagg cccaacatcc tcatcccagg caccctggag      480

tccggctgcc cccagaatct gacctgctct gtgccctggg cctgtgagca ggggacaccc      540

cctatgatct cctggatagg gacctccgtg tcccccctgg acccctccac cacccgctcc      600

tcggtgctca ccctcatccc acagccccag gaccatggca ccagcctcac ctgtcaggtg      660

accttccctg gggccagcgt gaccacgaac aagaccgtcc atctcaacgt gtcctacccg      720

cctcagaact tgaccatgac tgtcttccaa ggagacggca cagtatccac agtcttggga      780

aatggctcat ctctgtcact cccagagggc cagtctctgc gcctggtctg tgcagttgat      840

gcagttgaca gcaatccccc tgccaggctg agcctgagct ggagaggcct gaccctgtgc      900

ccctcacagc cctcaaaccc gggggtgctg gagctgcctt gggtgcacct gagggatgca      960

gctgaattca cctgcagagc tcagaaccct ctcggctctc agcaggtcta cctgaacgtc     1020

tccatcgaag tgatgtatcc acccccttac ctggataacg agaagagcaa tggcaccatc     1080

atccacgtga agggcaagca cctgtgccct tctccactgt tccccggccc tagcaagccc     1140

ttttgggtgc tggtggtggt gggaggcgtg ctggcctgtt attctctgct ggtgacagtg     1200

gcctttatta ttttctgggt gaagagaggc aggaagaagc tgctgtacat cttcaagcag     1260

cccttcatgc ggcccgtgca gacaacccag gaggaggacg gctgctcctg taggttccct     1320

gaagaggagg agggaggatg tgagctg                                         1347


<210>  50
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S928_G CSR construct nt sequence

<400>  50
atgtccgcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc       60

aggccacaga caagtaaact gctgacgatg cagagttccg tgacggtgca ggaaggcctg      120

tgtgtccatg tgccctgctc cttctcctac ccctcgcatg gctggattta ccctggccca      180

gtagttcatg gctactggtt ccgggaaggg gccaatacag accaggatgc tccagtggcc      240

acaaacaacc cagctcgggc agtgtgggag gagactcggg accgattcca cctccttggg      300

gacccacata ccaagaattg caccctgagc atcagagatg ccagaagaag tgatgcgggg      360

agatacttct ttcgtatgga gaaaggaagt ataaaatgga attataaaca tcaccggctc      420

tctgtgaatg tgacagcctt gacccacagg cccaacatcc tcatcccagg caccctggag      480

tccggctgcc cccagaatct gacctgctct gtgccctggg cctgtgagca ggggacaccc      540

cctatgatct cctggatagg gacctccgtg tcccccctgg acccctccac cacccgctcc      600

tcggtgctca ccctcatccc acagccccag gaccatggca ccagcctcac ctgtcaggtg      660

accttccctg gggccagcgt gaccacgaac aagaccgtcc atctcaacgt gtcctacccg      720

cctcagaact tgaccatgac tgtcttccaa ggagacggca cagtatccac agtcttggga      780

aatggctcat ctctgtcact cccagagggc cagtctctgc gcctggtctg tgcagttgat      840

gcagttgaca gcaatccccc tgccaggctg agcctgagct ggagaggcct gaccctgtgc      900

ccctcacagc cctcaaaccc gggggtgctg gagctgcctt gggtgcacct gagggatgca      960

gctgaattca cctgcagagc tcagaaccct ctcggctctc agcaggtcta cctgaacgtc     1020

tccaagccca ccacaacccc tgcaccacgc ccacccacac cagcacctac catcgcaagc     1080

cagccactgt ccctgcggcc cgaggcctgt aggccagcag caggaggagc agtgcacacc     1140

aggggcctgg actttgcctg cgatatctac atctgggcac cactggcagg aacatgtggc     1200

gtgctgctgc tgagcctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1260

tacatcttca agcagccctt catgcggccc gtgcagacaa cccaggagga ggacggctgc     1320

tcctgtaggt tccctgaaga ggaggaggga ggatgtgagc tg                        1362


<210>  51
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Tyr Xaa Xaa Met 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  52

Tyr Met Asn Met 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  53

Pro Arg Arg Pro 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  54

Pro Tyr Ala Pro 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  55

Gln Glu Glu Asp 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  56

Glu Glu Glu Glu 
1               


<210>  57
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  57

Thr Pro Ile Gln Glu Glu 
1               5       


<210>  58
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  58

Glu Glu Gly Lys Glu 
1               5   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  59

Val Thr Thr Val Glu Val Glu Glu Thr 
1               5                   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  binding motif

<400>  60

Pro Ile Gln Glu Asp 
1               5   


<210>  61
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (16)..(20)
<223>  may be absent

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  63
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (5)..(10)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(15)
<223>  may be absent

<400>  63

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  64
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  64

Pro Ala Pro Ala 
1               


