                               SEQUENCE LISTING

<110> GENKIN, DMITRY DMITRIEVICH
      STEPANOV, ALEXEY VYACHESLAVOVICH
      DUBINA, MICHAEL VLADIMIROVICH
      BOGDANOV, ALEXEY ALEXANDROVICH 
      GABIBOV, ALEXANDER GABIBOVICH 
 
<120> REPROGRAMMING OF POLYMORPHONUCLEAR LEUKOCYTES

<130> 255035.000003

<140> PCT/IB2020/000291
<141> 2020-04-17

<150> 62/835,785
<151> 2019-04-18

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 1671
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
atgctgctgc tggtcacttc tctgctgctg tgcgaactgc cccaccccgc ctttctgctg       60

attcccgaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga      120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag      180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc      240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg      300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc      360

ggagggggga ccaagctgga gatcacaggt ggcggtggct cgggcggtgg tgggtcgggt      420

ggcggcggat ctgaggtgaa actgcaggag tcaggacctg gcctggtggc gccctcacag      480

agcctgtccg tcacatgcac tgtctcaggg gtctcattac ccgactatgg tgtaagctgg      540

attcgccagc ctccacgaaa gggtctggag tggctgggag taatatgggg tagtgaaacc      600

acatactata attcagctct caaatccaga ctgaccatca tcaaggacaa ctccaagagc      660

caagttttct taaaaatgaa cagtctgcaa actgatgaca cagccattta ctactgtgcc      720

aaacattatt actacggtgg tagctatgct atggactact ggggccaagg aacctcagtc      780

accgtctcct cagaacagaa actgatttcc gaggaagatc tgttcgtccc cgtgttcctg      840

cctgccaagc caacaactac ccctgctcca cgaccaccta ctccagcacc taccatcgca      900

agtcagcccc tgtcactgcg acctgaggct tgccggccag cagctggagg agcagtgcac      960

acccgaggcc tggacttcgc atgcgatatc tacatttggg caccactggc tggaacctgt     1020

ggggtcctgc tgctgagcct ggtcatcacc ctgtattgta accacagaaa taggagcaaa     1080

cgctcccgac tgctgcattc cgactacatg aacatgacac ctcggagacc aggccccact     1140

agaaagcatt accagccata tgccccaccc agggatttcg cagcctatcg gagccggttc     1200

agcgtcgtga aaagggggcg caagaaactg ctgtacatct tcaagcagcc ttttatgcgc     1260

ccagtgcaga caactcagga ggaagacgga tgctcttgtc ggttcccaga ggaggaggaa     1320

ggaggctgcg agctgagagt gaagttcagc cggagcgccg atgcaccagc atatcagcag     1380

ggacagaatc agctgtacaa cgagctgaat ctgggcaggc gcgaggaata tgacgtgctg     1440

gataagcgac gaggacggga ccccgaaatg ggaggaaaac ccagaaggaa gaaccctcag     1500

gaggggctgt ataatgaact gcagaaagac aagatggctg aggcatacag cgaaattgga     1560

atgaaaggag agcgccgacg ggggaaggga cacgatgggc tgtaccaggg actgtcaacc     1620

gccactaaag atacctacga cgcactgcac atgcaggctc tgcccccaag a              1671


<210> 2
<211> 1512
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gcttgtattc ttgatttgcc gaagttttgc ggtggaggtt cggctagcga gcccaaatct      120

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaggctcc accagcggca gcggcaagcc aggctccggc      840

gaaggcagca ccaaaggctt ctgggtcctg gtcgtggtgg ggggggtgtt ggcctgttat      900

agcctgctgg tgactgtcgc cttcattata ttttgggtga gatccaaaag atcccggctg      960

ctccattctg actacatgaa catgactcca aggcgaccag gacctactag aaagcattat     1020

cagccgtacg ctccaccccg ggattttgcg gcttatcgaa gtagggacca gagattgccc     1080

cctgacgccc acaagcctcc cgggggggga agcttccgca cccccatcca ggaagaacaa     1140

gcagatgcac atagtactct ggccaaaata agagtgaagt tttctagaag cgcagacgca     1200

ccagcttacc agcagggcca aaatcagctg tacaacgagc tgaacctggg ccggagggag     1260

gaatacgatg tgctggataa gcgccggggc cgcgatcccg aaatgggcgg caagccacgg     1320

cgaaagaatc ctcaggaggg actgtacaac gaactccaaa aggacaagat ggcggaggca     1380

tactccgaga tcggcatgaa gggggaaaga cggcggggca aggggcatga cggtctgtat     1440

caagggttga gtaccgccac aaaggatacc tacgacgccc ttcacatgca ggccctgccc     1500

cctcgctagt aa                                                         1512


<210> 3
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu Glu 
            260                 265                 270         


Asp Leu Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            340                 345                 350         


Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        355                 360                 365             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    370                 375                 380                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe 
385                 390                 395                 400 


Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                405                 410                 415     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            420                 425                 430         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        435                 440                 445             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    450                 455                 460                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
465                 470                 475                 480 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                485                 490                 495     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            500                 505                 510         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        515                 520                 525             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    530                 535                 540                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 555         


<210> 4
<211> 502
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Cys Ile Leu Asp Leu Pro Lys Phe Cys Gly Gly 
            20                  25                  30          


Gly Ser Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Ser 
            260                 265                 270         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
        355                 360                 365             


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
    370                 375                 380                 


Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg 
            500         


<210> 5
<211> 1401
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
atgcaggtac aactgcagca gtctgggcct gagctggaga agcctggcgc ttcagtgaag       60

atatcctgca aggcttctgg ttactcattc actggctaca ccatgaactg ggtgaagcag      120

agccatggaa agagccttga gtggattgga cttattactc cttacaatgg tgcttctagc      180

tacaaccaga agttcagggg caaggccaca ttaactgtag acaagtcatc cagcacagcc      240

tacatggacc tcctcagtct gacatctgaa gactctgcag tctatttctg tgcaaggggg      300

ggttacgacg ggaggggttt tgactactgg ggccaaggga ccacggtcac cgtctcctca      360

ggtgtaggcg gttcaggcgg cggtggctct ggcggtggcg gatcggacat cgagctcact      420

cagtctccag caatcatgtc tgcatctcca ggggagaagg tcaccatgac ctgcagtgcc      480

agctcaagtg taagttacat gcactggtac cagcagaagt caggcacctc ccccaaaaga      540

tggatttatg acacatccaa actggcttct ggagtcccag gtcgcttcag tggcagtggg      600

tctggaaact cttactctct cacaatcagc agcgtggagg ctgaagatga tgcaacttat      660

tactgccagc agtggagtgg ttaccctctc acgttcggtg ctgggacaaa gttggaaata      720

aaatccggaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      780

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      840

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      900

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg      960

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1020

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgcta a                                               1401


<210> 6
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly 
            20                  25                  30          


Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    290                 295                 300                 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
305                 310                 315                 320 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                325                 330                 335     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            340                 345                 350         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 


Pro Arg 
465     


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Met Leu Trp Arg Arg Lys Ile Gly Pro Gln Met Thr Leu Ser Ala Gly 
1               5                   10                  15      


<210> 8
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Met Ser Glu Thr Ala Pro Leu Ala Pro Thr Ile Pro Ala Pro Ala 
1               5                   10                  15      


Glu Lys Thr Pro Val Lys Lys Lys Ala Lys Lys Ala Gly Ala Thr Ala 
            20                  25                  30          


Gly Lys Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys 
        35                  40                  45              


Ala Val Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu 
    50                  55                  60                  


Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser 
65                  70                  75                  80  


Arg Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val 
                85                  90                  95      


Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys 
            100                 105                 110         


Ala Ala Ser Gly Glu Gly Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala 
        115                 120                 125             


Lys Pro Arg Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Val Ala 
    130                 135                 140                 


Gly Ala Ala Thr Pro Lys Lys Ser Ile Lys Lys Thr Pro Lys Lys Val 
145                 150                 155                 160 


Lys Lys Pro Ala Thr Ala Ala Gly Thr Lys Lys Val Ala Lys Ser Ala 
                165                 170                 175     


Lys Lys Val Lys Thr Pro Gln Pro Lys Lys Ala Ala Lys Ser Pro Ala 
            180                 185                 190         


Lys Ala Lys Ala Pro Lys Pro Lys Ala Ala Lys Pro Lys Ser Gly Lys 
        195                 200                 205             


Pro Lys Val Thr Lys Ala Lys Lys Ala Ala Pro Lys Lys Lys 
    210                 215                 220         


