                         SEQUENCE LISTING

<110>  Turun yliopisto
 
<120>  Method for predicting response to treatment with tyrosine kinase 
       inhibitors and related methods

<130>  2190712

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2010
<212>  DNA
<213>  Homo sapiens

<400>  1
atggactcca ctgcctgctt gaagtccttg ctcctgactg tcagtcagta caaagccgtg       60

aagtcagagg cgaacgccac tcagcttttg cggcacttgg aggtaatttc tggacagaaa      120

ctcacacgac tatttacatc aaatcagata ttaacaagtg aatgcttgag ttgccttgta      180

gagctacttg aagaccccaa cataagtgct tcactgatct taagtattat cggtttgctg      240

tctcaactag cagtagacat tgaaaccaga gattgtcttc agaatacata taatctgaat      300

agtgtgctgg cgggagtggt ttgtcggagc agccacactg attcggtgtt tttgcagtgc      360

attcaacttc tacagaagtt aacatataat gtcaaaattt tctattctgg tgccaatata      420

gatgaattaa ttacgttcct gatagatcac attcaatctt ctgaagatga gttaaaaatg      480

ccttgtctag gattattggc aaatctttgt cggcacaatc tttctgttca aacgcacata      540

aagacattga gtaatgtgaa atctttttat cgaactctta tcaccttgtt ggcccatagt      600

agtttaactg tggttgtgtt tgcactttca atattatcca gtttgacatt aaatgaagag      660

gtgggggaaa agctattcca tgctcgaaac attcatcaga cttttcaact aatatttaat      720

attctcataa acggtgatgg cactctaact agaaagtatt cagttgacct actgatggat      780

ctccttaaga atcctaaaat tgctgattat ctcaccagat atgagcactt ttcttcatgt      840

cttcaccaag tattaggtct tcttaatgga aaggatcctg attcctcttc aaaggtttta      900

gaattacttc ttgccttctg ttcagtgact cagctgcgcc atatgctcac tcagatgatg      960

tttgaacagt ctccacctgg cagcgccact ctgggaagcc atactaaatg tttagaacct     1020

actgtggctc tactgcgctg gttaagccaa cctttggacg gatcagaaaa ctgttctgtt     1080

ttagcattgg agttgttcaa ggaaatattt gaggatgtca tagatgctgc taactgttcc     1140

tcggctgatc gttttgtgac ccttctgctg cctacaatcc ttgatcaact tcagttcaca     1200

gaacaaaatc tagatgaggc tttaacaaga aaaaaatgtg aaaggattgc caaggccatt     1260

gaagttttgt taactctctg tggagatgat acactaaaaa tgcatattgc aaaaatcttg     1320

acaactgtca agtgtaccac tcttatagaa caacaattta catatggcaa gattgacctg     1380

ggatttggaa caaaggttgc agattctgaa ttatgcaaac ttgctgctga tgtaattttg     1440

aaaactcttg atttgattaa caaacttaaa ccattggttc ctggtatgga agtaagcttc     1500

tacaaaatac ttcaggaccc acgtttgatt actcctttgg cttttgcttt aacgtcagat     1560

aatagagaac aagtacagtc tggactgaga atattattgg aggctgctcc actgccagat     1620

tttcctgctt tagtcaacaa caaaaataca caggaagctt ttcaagttac aagttaaaag     1680

tggtctgtaa agctgctcta ttttgtggtg gcctgcttgc ataaactggt aatctgacat     1740

gaaacaaaac cttaagagct tcaaagggga atctgcagcc tcactgaaca tggaagtctt     1800

atcctctgcc tctgtgtgtg aggccttccc accattttga ctgtgtcttg gcattccctg     1860

tcttatttgt gttgtaaata attttctctt tgggcattat ctcagatgtc cattttatgc     1920

ttactattta atgcccttat ttgacattat cttgggcgtt taataaactg aatgtatatt     1980

atgaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      2010


<210>  2
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ser Thr Ala Cys Leu Lys Ser Leu Leu Leu Thr Val Ser Gln 
1               5                   10                  15      


Tyr Lys Ala Val Lys Ser Glu Ala Asn Ala Thr Gln Leu Leu Arg His 
            20                  25                  30          


Leu Glu Val Ile Ser Gly Gln Lys Leu Thr Arg Leu Phe Thr Ser Asn 
        35                  40                  45              


Gln Ile Leu Thr Ser Glu Cys Leu Ser Cys Leu Val Glu Leu Leu Glu 
    50                  55                  60                  


Asp Pro Asn Ile Ser Ala Ser Leu Ile Leu Ser Ile Ile Gly Leu Leu 
65                  70                  75                  80  


Ser Gln Leu Ala Val Asp Ile Glu Thr Arg Asp Cys Leu Gln Asn Thr 
                85                  90                  95      


Tyr Asn Leu Asn Ser Val Leu Ala Gly Val Val Cys Arg Ser Ser His 
            100                 105                 110         


Thr Asp Ser Val Phe Leu Gln Cys Ile Gln Leu Leu Gln Lys Leu Thr 
        115                 120                 125             


Tyr Asn Val Lys Ile Phe Tyr Ser Gly Ala Asn Ile Asp Glu Leu Ile 
    130                 135                 140                 


Thr Phe Leu Ile Asp His Ile Gln Ser Ser Glu Asp Glu Leu Lys Met 
145                 150                 155                 160 


Pro Cys Leu Gly Leu Leu Ala Asn Leu Cys Arg His Asn Leu Ser Val 
                165                 170                 175     


Gln Thr His Ile Lys Thr Leu Ser Asn Val Lys Ser Phe Tyr Arg Thr 
            180                 185                 190         


Leu Ile Thr Leu Leu Ala His Ser Ser Leu Thr Val Val Val Phe Ala 
        195                 200                 205             


Leu Ser Ile Leu Ser Ser Leu Thr Leu Asn Glu Glu Val Gly Glu Lys 
    210                 215                 220                 


Leu Phe His Ala Arg Asn Ile His Gln Thr Phe Gln Leu Ile Phe Asn 
225                 230                 235                 240 


Ile Leu Ile Asn Gly Asp Gly Thr Leu Thr Arg Lys Tyr Ser Val Asp 
                245                 250                 255     


Leu Leu Met Asp Leu Leu Lys Asn Pro Lys Ile Ala Asp Tyr Leu Thr 
            260                 265                 270         


Arg Tyr Glu His Phe Ser Ser Cys Leu His Gln Val Leu Gly Leu Leu 
        275                 280                 285             


Asn Gly Lys Asp Pro Asp Ser Ser Ser Lys Val Leu Glu Leu Leu Leu 
    290                 295                 300                 


Ala Phe Cys Ser Val Thr Gln Leu Arg His Met Leu Thr Gln Met Met 
305                 310                 315                 320 


Phe Glu Gln Ser Pro Pro Gly Ser Ala Thr Leu Gly Ser His Thr Lys 
                325                 330                 335     


Cys Leu Glu Pro Thr Val Ala Leu Leu Arg Trp Leu Ser Gln Pro Leu 
            340                 345                 350         


Asp Gly Ser Glu Asn Cys Ser Val Leu Ala Leu Glu Leu Phe Lys Glu 
        355                 360                 365             


Ile Phe Glu Asp Val Ile Asp Ala Ala Asn Cys Ser Ser Ala Asp Arg 
    370                 375                 380                 


Phe Val Thr Leu Leu Leu Pro Thr Ile Leu Asp Gln Leu Gln Phe Thr 
385                 390                 395                 400 


Glu Gln Asn Leu Asp Glu Ala Leu Thr Arg Lys Lys Cys Glu Arg Ile 
                405                 410                 415     


Ala Lys Ala Ile Glu Val Leu Leu Thr Leu Cys Gly Asp Asp Thr Leu 
            420                 425                 430         


Lys Met His Ile Ala Lys Ile Leu Thr Thr Val Lys Cys Thr Thr Leu 
        435                 440                 445             


Ile Glu Gln Gln Phe Thr Tyr Gly Lys Ile Asp Leu Gly Phe Gly Thr 
    450                 455                 460                 


Lys Val Ala Asp Ser Glu Leu Cys Lys Leu Ala Ala Asp Val Ile Leu 
465                 470                 475                 480 


Lys Thr Leu Asp Leu Ile Asn Lys Leu Lys Pro Leu Val Pro Gly Met 
                485                 490                 495     


Glu Val Ser Phe Tyr Lys Ile Leu Gln Asp Pro Arg Leu Ile Thr Pro 
            500                 505                 510         


Leu Ala Phe Ala Leu Thr Ser Asp Asn Arg Glu Gln Val Gln Ser Gly 
        515                 520                 525             


Leu Arg Ile Leu Leu Glu Ala Ala Pro Leu Pro Asp Phe Pro Ala Leu 
    530                 535                 540                 


Val Asn Asn Lys Asn Thr Gln Glu Ala Phe Gln Val Thr Ser 
545                 550                 555             


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Asn Lys Asn Thr Gln Glu Ala Phe Gln Val Thr Ser 
1               5                   10              


<210>  4
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOCIVA forward primer

<400>  4
cagtctggac tgagaatatt attgga                                            26


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOCIVA reverse primer

<400>  5
ggcattgttt gctgctatac ttt                                               23


<210>  6
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOCIVA probe

<400>  6
tccactgc                                                                 8


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b-actin forward primer

<400>  7
tcacccacac rgtgcccatc tacgc                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b-actin reverse primer

<400>  8
cagcggaacc gctcattgcc aatgg                                             25


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b-actin probe

<400>  9
atgccctccc ccatgccatc ctgcgt                                            26


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH forward primer

<400>  10
acccactcct ccacctttga                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH reverse primer

<400>  11
ttgctgtagc caaattcgtt gt                                                22


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH probe

<400>  12
acgaccactt tgtcaagctc atttcctggt                                        30


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARPP19 forward primer

<400>  13
cagagggagc actatgtctg c                                                 21


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARPP19 reverse primer

<400>  14
gcttttaatt ttgcttcttc tgct                                              24


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOCIVA forward primer

<400>  15
atgccaagac acagtcaaaa tg                                                22


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOCIVA reverse primer

<400>  16
cctgcttgca taaactggta atc                                               23


<210>  17
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOCIVA probe

<400>  17
cagaggcaga ggataa                                                       16


