                         SEQUENCE LISTING

<110>  GENETHON
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE D'EVRY VAL D'ESSONNE
 
<120>  GENE THERAPY OF FIBROBLAST GROWTH FACTOR 23 RELATED 
       HYPOPHOSPHATEMIC DISEASES

<130>  BCT200107 QT

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  2
<211>  77
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (human FGF23 C-term peptide 175-251)

<400>  2

Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu 
1               5                   10                  15      


Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys 
            20                  25                  30          


Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp 
        35                  40                  45              


Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly 
    50                  55                  60                  


Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
65                  70                  75          


<210>  3
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (human FGF23 signal peptide)

<400>  3

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala 
            20                  


<210>  4
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (alpha-1 anti-trypsin signal peptide)

<400>  4

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Lys Leu 
            20                  25      


<210>  5
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (synthetic mut1 signal peptide)

<400>  5

Met Leu Leu Leu Ser Ala Leu Leu Leu Gly Leu Ala Phe Gly Tyr Ser 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (synthetic mut3 signal peptide)

<400>  6

Met Leu Leu Ser Phe Ala Leu Leu Leu Gly Leu Ala Leu Gly Tyr Ser 
1               5                   10                  15      


<210>  7
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (chymotrypsin B2 (CTRB2) signal peptide)

<400>  7

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  8
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (plasma protease C1 signal peptide)

<400>  8

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser 
            20          


<210>  9
<211>  585
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (human serum albumin 25-609)

<400>  9

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  10
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (FIX activation sequence (1))

<400>  10

Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro 
1               5                   10                  15      


Asp Val Asp Gly Ser 
            20      


<210>  11
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (FIX activation sequence (2))

<400>  11

Pro Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro 
1               5                   10                  15      


Asp Val 
        


<210>  12
<211>  701
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  12

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Ser 
                85                  90                  95      


Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
            100                 105                 110         


Val Asp Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
        115                 120                 125             


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
    130                 135                 140                 


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
145                 150                 155                 160 


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
                165                 170                 175     


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
            180                 185                 190         


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
        195                 200                 205             


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
    210                 215                 220                 


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
225                 230                 235                 240 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
                245                 250                 255     


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
            260                 265                 270         


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
        275                 280                 285             


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
    290                 295                 300                 


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
305                 310                 315                 320 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
                325                 330                 335     


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
            340                 345                 350         


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
        355                 360                 365             


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
    370                 375                 380                 


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
385                 390                 395                 400 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
                405                 410                 415     


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
            420                 425                 430         


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
        435                 440                 445             


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
    450                 455                 460                 


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
                485                 490                 495     


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
            500                 505                 510         


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
        515                 520                 525             


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
    530                 535                 540                 


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
545                 550                 555                 560 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
                565                 570                 575     


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
            580                 585                 590         


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
        595                 600                 605             


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
    610                 615                 620                 


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
625                 630                 635                 640 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
                645                 650                 655     


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
            660                 665                 670         


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
        675                 680                 685             


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    690                 695                 700     


<210>  13
<211>  2106
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide codon optimized

<400>  13
atggctttct tgtggcttct cagttgttgg gccttgttgg ggaccacttt cggacgaaga       60

cacacacgct ctgcagagga cgattctgag agggatcctt tgaatgtcct taagccgagg      120

gcccgcatga cgcctgcacc agcatcctgc agtcaagagc tcccttcagc agaagataat      180

agtcctatgg cgtccgaccc cctgggggta gtacgcgggg ggcgagttaa tacgcacgcc      240

gggggaactg gtcctgaagg gtgcaggccc tttgccaagt ttatttcagt gtcacaaacc      300

tctaaactga cacgcgccga gacggtcttt ccggatgttg atggatcaga tgctcataaa      360

tcagaggtag ctcaccgctt caaagacctc ggagaggaga actttaaggc cctcgtcctc      420

atcgcatttg cacagtattt gcaacaatgt ccctttgagg atcatgtcaa attggtaaat      480

gaagttactg agttcgcgaa gacatgcgtg gctgacgagt ccgcagaaaa ctgcgacaag      540

tcccttcata cactgtttgg tgataaactg tgcactgtcg ctactcttag agaaacatat      600

ggagagatgg ctgactgttg tgcgaagcaa gagccagaac ggaatgaatg tttccttcaa      660

cataaagatg ataatccgaa tttgccacgc cttgtacgac cagaggtgga tgttatgtgc      720

accgcgtttc atgacaatga ggaaacgttc ctgaaaaaat atttgtatga gattgctcgg      780

agacatcctt acttttacgc acccgagctc ctgttcttcg ctaagagata caaggcagcc      840

tttacggaat gctgtcaggc cgcggataag gccgcctgct tgctccccaa gctggacgag      900

ctgcgagatg agggcaaggc gtcctctgct aagcaacgac tcaaatgcgc cagcttgcaa      960

aagtttggcg aaagagcgtt taaggcctgg gcagtggcgc gcctgagtca gcggttccct     1020

aaggcggagt ttgccgaggt ctcaaaactg gtgacagact tgacgaaggt acataccgag     1080

tgctgccacg gagatctcct ggagtgcgcg gatgatcgcg ctgacctcgc caaatatata     1140

tgtgagaacc aggattccat ttcctcaaaa cttaaagagt gctgcgaaaa accccttctt     1200

gagaagtcac actgcattgc agaggtcgaa aacgacgaaa tgcctgccga tctgccttcc     1260

cttgcggctg actttgtgga gtctaaggac gtttgcaaaa actatgcaga ggctaaagac     1320

gtattcctgg gcatgtttct ttatgaatac gcgcggcgac atcccgacta ttcagtcgta     1380

ctcctgcttc gactggcgaa aacttacgaa actactctcg agaaatgctg tgctgccgcc     1440

gaccctcatg agtgctatgc taaggtattt gatgaattca aaccgttggt tgaggaaccg     1500

caaaacttga tcaagcagaa ctgtgaactt tttgagcagc tgggggaata taaattccag     1560

aatgcattgc ttgtacgata cacaaagaaa gttccacagg tctccacccc gacacttgtg     1620

gaagttagca ggaacttggg aaaggtcggc agcaagtgtt gtaagcaccc tgaagctaag     1680

cgaatgccat gcgccgaaga ttacctttct gtggtgttga accaactgtg cgttcttcac     1740

gaaaagacgc ccgtatctga tcgggtgacg aaatgctgca cagagtcact tgtgaacaga     1800

cgcccctgct ttagtgcgct cgaggtggac gaaacgtatg tcccgaaaga gtttaacgca     1860

gagacattca cgtttcatgc ggacatctgt accctctctg aaaaggagag acagatcaaa     1920

aagcagacag cgctggttga gcttgttaag cataagccga aggcgacaaa ggagcaactg     1980

aaagcggtga tggatgactt cgccgcgttc gttgaaaaat gctgcaaagc cgacgataag     2040

gaaacctgtt ttgctgaaga aggtaaaaaa ctcgttgctg cgagtcaggc cgccctgggg     2100

ctgtga                                                                2106


<210>  14
<211>  397
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (hAAT promoter)

<400>  14
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agtgaat                               397


<210>  15
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (ApoE enhancer)

<400>  15
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  16
<211>  441
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (HBB2 intron)

<400>  16
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt       60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca      120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata      180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt      240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt      300

ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      360

tcatgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctgtgtgc      420

tggcccatca ctttggcaaa g                                                441


<210>  17
<211>  441
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (modified HBB2 intron)

<400>  17
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt       60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca      120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata      180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt      240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt      300

ttattttctg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc      420

tggcccatca ctttggcaaa g                                                441


<210>  18
<211>  1438
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (FIX intron)

<400>  18
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct       60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta      120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc      180

atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt      240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa      300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta      360

tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc      420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt      480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa      540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta      600

ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa      660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga      720

agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt      780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac      840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt      900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc      960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt     1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc     1080

agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg     1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt     1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt     1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct     1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta     1380

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca       1438


<210>  19
<211>  1438
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (modified FIX intron)

<400>  19
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct       60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta      120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc      180

atttttaaaa ctaaatagat cgacattgct tttgttgcat ttatgtttaa taaacactgt      240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa      300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta      360

tttttgtttg gacttaccac tttgaaatca aattgggaaa caaaagcaca aacaatggcc      420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt      480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa      540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta      600

ggaaaaaatc attttgtctc tttgtcaaac atcttggagt tgatatttgg ggaaacacaa      660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga      720

agttagctat tgcaacatat atcactttgt tttttcacaa ctacagtgac tttttgtatt      780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc ttgttctcac      840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt      900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc      960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt     1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc     1080

agggtgttgg atcactttgc aaagatcctc attgagctat tttcaagtgt tgacaaagtg     1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt     1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt     1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct     1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta     1380

aaattttctt gttgttttct tttttgctaa aactaaagaa ttattctttt acatttca       1438


<210>  20
<211>  881
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (chicken beta globin intron)

<400>  20
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca      480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg      540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc      600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg      660

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc      720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac      780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga      840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                          881


<210>  21
<211>  881
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (Modified chicken beta-globin intron)

<400>  21
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca      480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg      540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc      600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg      660

cggctgtcga ggcgcggcga gccgcagcca ttgccttttt tggtaatcgt gcgagagggc      720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac      780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaat tgggcgggga      840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                          881


<210>  22
<211>  169
<212>  DNA
<213>  artificial seqeunce

<220>
<223>  synthetic polynucleotide (bGH polyA)

<400>  22
tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct       60

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct      120

gagtaggtgt cattctattc tggggggtgg ggtgggggct agctctaga                  169


<210>  23
<211>  3598
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (expression cassette)

<400>  23
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat      840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat      900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat      960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1260

ctttggcaaa gcacgcgtgc caccatggct ttcttgtggc ttctcagttg ttgggccttg     1320

ttggggacca ctttcggacg aagacacaca cgctctgcag aggacgattc tgagagggat     1380

cctttgaatg tccttaagcc gagggcccgc atgacgcctg caccagcatc ctgcagtcaa     1440

gagctccctt cagcagaaga taatagtcct atggcgtccg accccctggg ggtagtacgc     1500

ggggggcgag ttaatacgca cgccggggga actggtcctg aagggtgcag gccctttgcc     1560

aagtttattt cagtgtcaca aacctctaaa ctgacacgcg ccgagacggt ctttccggat     1620

gttgatggat cagatgctca taaatcagag gtagctcacc gcttcaaaga cctcggagag     1680

gagaacttta aggccctcgt cctcatcgca tttgcacagt atttgcaaca atgtcccttt     1740

gaggatcatg tcaaattggt aaatgaagtt actgagttcg cgaagacatg cgtggctgac     1800

gagtccgcag aaaactgcga caagtccctt catacactgt ttggtgataa actgtgcact     1860

gtcgctactc ttagagaaac atatggagag atggctgact gttgtgcgaa gcaagagcca     1920

gaacggaatg aatgtttcct tcaacataaa gatgataatc cgaatttgcc acgccttgta     1980

cgaccagagg tggatgttat gtgcaccgcg tttcatgaca atgaggaaac gttcctgaaa     2040

aaatatttgt atgagattgc tcggagacat ccttactttt acgcacccga gctcctgttc     2100

ttcgctaaga gatacaaggc agcctttacg gaatgctgtc aggccgcgga taaggccgcc     2160

tgcttgctcc ccaagctgga cgagctgcga gatgagggca aggcgtcctc tgctaagcaa     2220

cgactcaaat gcgccagctt gcaaaagttt ggcgaaagag cgtttaaggc ctgggcagtg     2280

gcgcgcctga gtcagcggtt ccctaaggcg gagtttgccg aggtctcaaa actggtgaca     2340

gacttgacga aggtacatac cgagtgctgc cacggagatc tcctggagtg cgcggatgat     2400

cgcgctgacc tcgccaaata tatatgtgag aaccaggatt ccatttcctc aaaacttaaa     2460

gagtgctgcg aaaaacccct tcttgagaag tcacactgca ttgcagaggt cgaaaacgac     2520

gaaatgcctg ccgatctgcc ttcccttgcg gctgactttg tggagtctaa ggacgtttgc     2580

aaaaactatg cagaggctaa agacgtattc ctgggcatgt ttctttatga atacgcgcgg     2640

cgacatcccg actattcagt cgtactcctg cttcgactgg cgaaaactta cgaaactact     2700

ctcgagaaat gctgtgctgc cgccgaccct catgagtgct atgctaaggt atttgatgaa     2760

ttcaaaccgt tggttgagga accgcaaaac ttgatcaagc agaactgtga actttttgag     2820

cagctggggg aatataaatt ccagaatgca ttgcttgtac gatacacaaa gaaagttcca     2880

caggtctcca ccccgacact tgtggaagtt agcaggaact tgggaaaggt cggcagcaag     2940

tgttgtaagc accctgaagc taagcgaatg ccatgcgccg aagattacct ttctgtggtg     3000

ttgaaccaac tgtgcgttct tcacgaaaag acgcccgtat ctgatcgggt gacgaaatgc     3060

tgcacagagt cacttgtgaa cagacgcccc tgctttagtg cgctcgaggt ggacgaaacg     3120

tatgtcccga aagagtttaa cgcagagaca ttcacgtttc atgcggacat ctgtaccctc     3180

tctgaaaagg agagacagat caaaaagcag acagcgctgg ttgagcttgt taagcataag     3240

ccgaaggcga caaaggagca actgaaagcg gtgatggatg acttcgccgc gttcgttgaa     3300

aaatgctgca aagccgacga taaggaaacc tgttttgctg aagaaggtaa aaaactcgtt     3360

gctgcgagtc aggccgccct ggggctgtga ctcgagagat ctaccggtga attcaccgcg     3420

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     3480

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3540

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga       3598


<210>  24
<211>  7559
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (AAV gene transfer vector

       pAAV hAAT sp7 FGF23-DNco)

<400>  24
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagag gatcaaggct cagaggcaca caggagtttc tgggctcacc ctgccccctt      240

ccaacccctc agttcccatc ctccagcagc tgtttgtgtg ctgcctctga agtccacact      300

gaacaaactt cagcctactc atgtccctaa aatgggcaaa cattgcaagc agcaaacagc      360

aaacacacag ccctccctgc ctgctgacct tggagctggg gcagaggtca gagacctctc      420

tgggcccatg ccacctccaa catccactcg accccttgga atttcggtgg agaggagcag      480

aggttgtcct ggcgtggttt aggtagtgtg agaggggtac ccggggatct tgctaccagt      540

ggaacagcca ctaaggattc tgcagtgaga gcagagggcc agctaagtgg tactctccca      600

gagactgtct gactcacgcc accccctcca ccttggacac aggacgctgt ggtttctgag      660

ccaggtacaa tgactccttt cggtaagtgc agtggaagct gtacactgcc caggcaaagc      720

gtccgggcag cgtaggcggg cgactcagat cccagccagt ggacttagcc cctgtttgct      780

cctccgataa ctggggtgac cttggttaat attcaccagc agcctccccc gttgcccctc      840

tggatccact gcttaaatac ggacgaggac agggccctgt ctcctcagct tcaggcacca      900

ccactgacct gggacagtga atagatcctg agaacttcag ggtgagtcta tgggaccctt      960

gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag gggagaagta     1020

acagggtaca catattgacc aaatcagggt aattttgcat ttgtaatttt aaaaaatgct     1080

ttcttctttt aatatacttt tttgtttatc ttatttctaa tactttccct aatctctttc     1140

tttcagggca ataatgatac aatgtatcat gcctctttgc accattctaa agaataacag     1200

tgataatttc tgggttaagg caatagcaat atttctgcat ataaatattt ctgcatataa     1260

attgtaactg atgtaagagg tttcatattg ctaatagcag ctacaatcca gctaccattc     1320

tgcttttatt ttctggttgg gataaggctg gattattctg agtccaagct aggccctttt     1380

gctaatcttg ttcatacctc ttatcttcct cccacagctc ctgggcaacc tgctggtctc     1440

tctgctggcc catcactttg gcaaagcacg cgtgccacca tggctttctt gtggcttctc     1500

agttgttggg ccttgttggg gaccactttc ggacgaagac acacacgctc tgcagaggac     1560

gattctgaga gggatccttt gaatgtcctt aagccgaggg cccgcatgac gcctgcacca     1620

gcatcctgca gtcaagagct cccttcagca gaagataata gtcctatggc gtccgacccc     1680

ctgggggtag tacgcggggg gcgagttaat acgcacgccg ggggaactgg tcctgaaggg     1740

tgcaggccct ttgccaagtt tatttcagtg tcacaaacct ctaaactgac acgcgccgag     1800

acggtctttc cggatgttga tggatcagat gctcataaat cagaggtagc tcaccgcttc     1860

aaagacctcg gagaggagaa ctttaaggcc ctcgtcctca tcgcatttgc acagtatttg     1920

caacaatgtc cctttgagga tcatgtcaaa ttggtaaatg aagttactga gttcgcgaag     1980

acatgcgtgg ctgacgagtc cgcagaaaac tgcgacaagt cccttcatac actgtttggt     2040

gataaactgt gcactgtcgc tactcttaga gaaacatatg gagagatggc tgactgttgt     2100

gcgaagcaag agccagaacg gaatgaatgt ttccttcaac ataaagatga taatccgaat     2160

ttgccacgcc ttgtacgacc agaggtggat gttatgtgca ccgcgtttca tgacaatgag     2220

gaaacgttcc tgaaaaaata tttgtatgag attgctcgga gacatcctta cttttacgca     2280

cccgagctcc tgttcttcgc taagagatac aaggcagcct ttacggaatg ctgtcaggcc     2340

gcggataagg ccgcctgctt gctccccaag ctggacgagc tgcgagatga gggcaaggcg     2400

tcctctgcta agcaacgact caaatgcgcc agcttgcaaa agtttggcga aagagcgttt     2460

aaggcctggg cagtggcgcg cctgagtcag cggttcccta aggcggagtt tgccgaggtc     2520

tcaaaactgg tgacagactt gacgaaggta cataccgagt gctgccacgg agatctcctg     2580

gagtgcgcgg atgatcgcgc tgacctcgcc aaatatatat gtgagaacca ggattccatt     2640

tcctcaaaac ttaaagagtg ctgcgaaaaa ccccttcttg agaagtcaca ctgcattgca     2700

gaggtcgaaa acgacgaaat gcctgccgat ctgccttccc ttgcggctga ctttgtggag     2760

tctaaggacg tttgcaaaaa ctatgcagag gctaaagacg tattcctggg catgtttctt     2820

tatgaatacg cgcggcgaca tcccgactat tcagtcgtac tcctgcttcg actggcgaaa     2880

acttacgaaa ctactctcga gaaatgctgt gctgccgccg accctcatga gtgctatgct     2940

aaggtatttg atgaattcaa accgttggtt gaggaaccgc aaaacttgat caagcagaac     3000

tgtgaacttt ttgagcagct gggggaatat aaattccaga atgcattgct tgtacgatac     3060

acaaagaaag ttccacaggt ctccaccccg acacttgtgg aagttagcag gaacttggga     3120

aaggtcggca gcaagtgttg taagcaccct gaagctaagc gaatgccatg cgccgaagat     3180

tacctttctg tggtgttgaa ccaactgtgc gttcttcacg aaaagacgcc cgtatctgat     3240

cgggtgacga aatgctgcac agagtcactt gtgaacagac gcccctgctt tagtgcgctc     3300

gaggtggacg aaacgtatgt cccgaaagag tttaacgcag agacattcac gtttcatgcg     3360

gacatctgta ccctctctga aaaggagaga cagatcaaaa agcagacagc gctggttgag     3420

cttgttaagc ataagccgaa ggcgacaaag gagcaactga aagcggtgat ggatgacttc     3480

gccgcgttcg ttgaaaaatg ctgcaaagcc gacgataagg aaacctgttt tgctgaagaa     3540

ggtaaaaaac tcgttgctgc gagtcaggcc gccctggggc tgtgactcga gagatctacc     3600

ggtgaattca ccgcgggttt aaactgtgcc ttctagttgc cagccatctg ttgtttgccc     3660

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3720

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3780

ggctagctct agagcatggc tacgtagata agtagcatgg cgggttaatc attaactaca     3840

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3900

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     3960

gagcgcgcag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc     4020

gcagcctgaa tggcgaatgg cgattccgtt gcaatggctg gcggtaatat tgttctggat     4080

attaccagca aggccgatag tttgagttct tctactcagg caagtgatgt tattactaat     4140

caaagaagta ttgcgacaac ggttaatttg cgtgatggac agactctttt actcggtggc     4200

ctcactgatt ataaaaacac ttctcaggat tctggcgtac cgttcctgtc taaaatccct     4260

ttaatcggcc tcctgtttag ctcccgctct gattctaacg aggaaagcac gttatacgtg     4320

ctcgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt     4380

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt     4440

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct     4500

ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg     4560

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga     4620

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc     4680

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga     4740

gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaaat     4800

atttgcttat acaatcttcc tgtttttggg gcttttctga ttatcaaccg gggtacatat     4860

gattgacatg ctagttttac gattaccgtt catcgattct cttgtttgct ccagactctc     4920

aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct ctccggcatg     4980

aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt ctccggcctt     5040

tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa aatatatgag     5100

ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag     5160

ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt attgcttaat     5220

tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaatcgt cctgatgcgg     5280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca     5340

atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg     5400

ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg     5460

agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc     5520

gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt     5580

ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca     5640

aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg     5700

aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc     5760

cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg     5820

ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt     5880

cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta     5940

ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat     6000

gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga     6060

gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca     6120

acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact     6180

cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc     6240

acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact     6300

ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt     6360

ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt     6420

gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt     6480

atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata     6540

ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag     6600

attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat     6660

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     6720

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     6780

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     6840

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg     6900

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     6960

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     7020

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     7080

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     7140

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     7200

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     7260

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     7320

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     7380

cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag     7440

tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa     7500

gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatg      7559


<210>  25
<211>  768
<212>  DNA
<213>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(768)

<400>  25
acgcgtgcca cc atg ttg ggg gcc cgc ctc agg ctc tgg gtc tgt gcc ttg       51
              Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu         
              1               5                   10                      

tgc agc gtc tgc agc atg agc gtc ctc aga gcc tat ccc aat gcc tcc         99
Cys Ser Val Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser           
    15                  20                  25                            

cca ctg ctc ggc tcc agc tgg ggt ggc ctg atc cac ctg tac aca gcc        147
Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala           
30                  35                  40                  45            

aca gcc agg aac agc tac cac ctg cag atc cac aag aat ggc cat gtg        195
Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val           
                50                  55                  60                

gat ggc gca ccc cat cag acc atc tac agt gcc ctg atg atc aga tca        243
Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser           
            65                  70                  75                    

gag gat gct ggc ttt gtg gtg att aca ggt gtg atg agc aga aga tac        291
Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr           
        80                  85                  90                        

ctc tgc atg gat ttc aga ggc aac att ttt gga tca cac tat ttc gac        339
Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp           
    95                  100                 105                           

ccg gag aac tgc agg ttc caa cac cag acg ctg gaa aac ggg tac gac        387
Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp           
110                 115                 120                 125           

gtc tac cac tct cct cag tat cac ttc ctg gtc agt ctg ggc cgg gcg        435
Val Tyr His Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala           
                130                 135                 140               

aag aga gcc ttc ctg cca ggc atg aac cca ccc ccg tac tcc cag ttc        483
Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe           
            145                 150                 155                   

ctg tcc cgg agg aac gag atc ccc cta att cac ttc aac acc ccc ata        531
Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile           
        160                 165                 170                       

cca cgg cgg cac acc cgg agc gcc gag gac gac tcg gag cgg gac ccc        579
Pro Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro           
    175                 180                 185                           

ctg aac gtg ctg aag ccc cgg gcc cgg atg acc ccg gcc ccg gcc tcc        627
Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser           
190                 195                 200                 205           

tgt tca cag gag ctc ccg agc gcc gag gac aac agc ccg atg gcc agt        675
Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser           
                210                 215                 220               

gac cca tta ggg gtg gtc agg ggc ggt cga gtg aac acg cac gct ggg        723
Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly           
            225                 230                 235                   

gga acg ggc ccg gaa ggc tgc cgc ccc ttc gcc aag ttc atc tag            768
Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile                   
        240                 245                 250                       


<210>  26
<211>  251
<212>  PRT
<213>  synthetic polynucleotide

<400>  26

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  27
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  27

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  28
<211>  768
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(768)

<400>  28
acgcgtgcca cc atg ttg ggc gcc agg ctt cgg ctc tgg gtc tgt gca ctg       51
              Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu         
              1               5                   10                      

tgc agt gtc tgt tcc atg agt gtg ttg cgg gct tac cct aac gca tca         99
Cys Ser Val Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser           
    15                  20                  25                            

ccg ctg ttg ggc tct tcc tgg ggt gga ctc ata cac ctt tat acg gcg        147
Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala           
30                  35                  40                  45            

act gcg cgc aat agc tac cat ttg caa ata cac aag aat ggg cat gtt        195
Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val           
                50                  55                  60                

gat ggt gct ccc cac cag act atc tac tct gct ctt atg att agg tca        243
Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser           
            65                  70                  75                    

gaa gac gcg ggg ttc gta gtt att act ggt gtt atg tcc cgc aga tat        291
Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr           
        80                  85                  90                        

ctc tgc atg gac ttc cgc ggt aac atc ttt ggg tca cac tat ttc gac        339
Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp           
    95                  100                 105                           

cca gag aac tgt cgc ttc cag cac cag acg ttg gag aat ggt tat gac        387
Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp           
110                 115                 120                 125           

gtg tat cac tcc ccg cag tac cat ttc ttg gtc tct ctg ggc cgg gcg        435
Val Tyr His Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala           
                130                 135                 140               

aaa agg gcc ttt ctg cca ggt atg aat cct ccg cct tat agt cag ttc        483
Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe           
            145                 150                 155                   

ctt agc agg cgg aac gaa att cct ctg att cac ttc aac acg ccg atc        531
Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile           
        160                 165                 170                       

cct cgc agg cat acg cga tcc gca gaa gac gat tct gag cga gat cct        579
Pro Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro           
    175                 180                 185                           

ctc aat gtt ctg aaa ccc cgc gcc cga atg acg cca gct ccg gcc agt        627
Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser           
190                 195                 200                 205           

tgt agt cag gag ttg ccg tct gcc gaa gat aat agt ccc atg gcc tcc        675
Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser           
                210                 215                 220               

gat cca ctt ggc gtg gta agg gga ggt aga gtt aac acc cac gcc ggt        723
Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly           
            225                 230                 235                   

gga act ggc cct gaa ggg tgt cgg cct ttt gcc aaa ttc ata tag            768
Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile                   
        240                 245                 250                       


<210>  29
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  30
<211>  315
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(315)

<400>  30
acgcgtgcca cc atg ttg ggg gcc cgc ctc agg ctc tgg gtc tgt gcc ttg       51
              Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu         
              1               5                   10                      

tgc agc gtc tgc agc atg agc gtc ctc aga gcc cga aga cac aca cgc         99
Cys Ser Val Cys Ser Met Ser Val Leu Arg Ala Arg Arg His Thr Arg           
    15                  20                  25                            

gcc gag gac gac tcg gag cgg gac ccc ctg aac gtg ctg aag ccc cgg        147
Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg           
30                  35                  40                  45            

gcc cgg atg acc ccg gcc ccg gcc tcc tgt tca cag gag ctc ccg agc        195
Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser           
                50                  55                  60                

gcc gag gac aac agc ccg atg gcc agt gac cca tta ggg gtg gtc agg        243
Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg           
            65                  70                  75                    

ggc ggt cga gtg aac acg cac gct ggg gga acg ggc ccg gaa ggc tgc        291
Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys           
        80                  85                  90                        

cgc ccc ttc gcc aag ttc atc tag                                        315
Arg Pro Phe Ala Lys Phe Ile                                               
    95                  100                                               


<210>  31
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  31

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Arg Arg His Thr Arg Ala Glu Asp 
            20                  25                  30          


Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met 
        35                  40                  45              


Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp 
    50                  55                  60                  


Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg 
65                  70                  75                  80  


Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe 
                85                  90                  95      


Ala Lys Phe Ile 
            100 


<210>  32
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  32

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Arg Arg His Thr Arg Ala Glu Asp 
            20                  25                  30          


Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met 
        35                  40                  45              


Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp 
    50                  55                  60                  


Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg 
65                  70                  75                  80  


Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe 
                85                  90                  95      


Ala Lys Phe Ile 
            100 


<210>  33
<211>  300
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(300)

<400>  33
acgcgtgcca cc atg ttg ggg gcc cgc ctc agg ctc tgg gtc tgt gcc ttg       51
              Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu         
              1               5                   10                      

tgc agc gtc tgc agc atg agc gtc ctc aga gcc gcc gag gac gac tcg         99
Cys Ser Val Cys Ser Met Ser Val Leu Arg Ala Ala Glu Asp Asp Ser           
    15                  20                  25                            

gag cgg gac ccc ctg aac gtg ctg aag ccc cgg gcc cgg atg acc ccg        147
Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro           
30                  35                  40                  45            

gcc ccg gcc tcc tgt tca cag gag ctc ccg agc gcc gag gac aac agc        195
Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser           
                50                  55                  60                

ccg atg gcc agt gac cca tta ggg gtg gtc agg ggc ggt cga gtg aac        243
Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn           
            65                  70                  75                    

acg cac gct ggg gga acg ggc ccg gaa ggc tgc cgc ccc ttc gcc aag        291
Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys           
        80                  85                  90                        

ttc atc tag                                                            300
Phe Ile                                                                   
    95                                                                    


<210>  34
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                85                  90                  95  


<210>  35
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  35

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                85                  90                  95  


<210>  36
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(321)

<400>  36
acgcgtgcca cc atg ttg ggc gcc agg ctt cgg ctc tgg gtc tgt gca ctg       51
              Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu         
              1               5                   10                      

tgc agt gtc tgt tcc atg agt gtg ttg cgg gct cga aga cac aca cgc         99
Cys Ser Val Cys Ser Met Ser Val Leu Arg Ala Arg Arg His Thr Arg           
    15                  20                  25                            

tct gca gag gac gat tct gag agg gat cct ttg aat gtc ctt aag ccg        147
Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro           
30                  35                  40                  45            

agg gcc cgc atg acg cct gca cca gca tcc tgc agt caa gag ctc cct        195
Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro           
                50                  55                  60                

tca gca gaa gat aat agt cct atg gcg tcc gac ccc ctg ggg gta gta        243
Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val           
            65                  70                  75                    

cgc ggg ggg cga gtt aat acg cac gcc ggg gga act ggt cct gaa ggg        291
Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly           
        80                  85                  90                        

tgc agg ccc ttt gcc aag ttt att gtt taa                                321
Cys Arg Pro Phe Ala Lys Phe Ile Val                                       
    95                  100                                               


<210>  37
<211>  102
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  37

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Arg Arg His Thr Arg Ser Ala Glu 
            20                  25                  30          


Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg 
        35                  40                  45              


Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu 
    50                  55                  60                  


Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly 
65                  70                  75                  80  


Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro 
                85                  90                  95      


Phe Ala Lys Phe Ile Val 
            100         


<210>  38
<211>  102
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  38

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Arg Arg His Thr Arg Ser Ala Glu 
            20                  25                  30          


Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg 
        35                  40                  45              


Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu 
    50                  55                  60                  


Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly 
65                  70                  75                  80  


Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro 
                85                  90                  95      


Phe Ala Lys Phe Ile Val 
            100         


<210>  39
<211>  306
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(306)

<400>  39
acgcgtgcca cc atg ttg ggc gcc agg ctt cgg ctc tgg gtc tgt gca ctg       51
              Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu         
              1               5                   10                      

tgc agt gtc tgt tcc atg agt gtg ttg cgg gct tct gca gag gac gat         99
Cys Ser Val Cys Ser Met Ser Val Leu Arg Ala Ser Ala Glu Asp Asp           
    15                  20                  25                            

tct gag agg gat cct ttg aat gtc ctt aag ccg agg gcc cgc atg acg        147
Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr           
30                  35                  40                  45            

cct gca cca gca tcc tgc agt caa gag ctc cct tca gca gaa gat aat        195
Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn           
                50                  55                  60                

agt cct atg gcg tcc gac ccc ctg ggg gta gta cgc ggg ggg cga gtt        243
Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val           
            65                  70                  75                    

aat acg cac gcc ggg gga act ggt cct gaa ggg tgc agg ccc ttt gcc        291
Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala           
        80                  85                  90                        

aag ttt att gtt taa                                                    306
Lys Phe Ile Val                                                           
    95                                                                    


<210>  40
<211>  97
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Ser Ala Glu Asp Asp Ser Glu Arg 
            20                  25                  30          


Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro 
        35                  40                  45              


Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met 
    50                  55                  60                  


Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His 
65                  70                  75                  80  


Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                85                  90                  95      


Val 
    


<210>  41
<211>  97
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  41

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Ser Ala Glu Asp Asp Ser Glu Arg 
            20                  25                  30          


Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro 
        35                  40                  45              


Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met 
    50                  55                  60                  


Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His 
65                  70                  75                  80  


Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                85                  90                  95      


Val 
    


<210>  42
<211>  303
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(303)

<400>  42
acgcgtgcca cc atg gct ttc ttg tgg ctt ctc agt tgt tgg gcc ttg ttg       51
              Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu         
              1               5                   10                      

ggg acc act ttc gga cga aga cac aca cgc tct gca gag gac gat tct         99
Gly Thr Thr Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser           
    15                  20                  25                            

gag agg gat cct ttg aat gtc ctt aag ccg agg gcc cgc atg acg cct        147
Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro           
30                  35                  40                  45            

gca cca gca tcc tgc agt caa gag ctc cct tca gca gaa gat aat agt        195
Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser           
                50                  55                  60                

cct atg gcg tcc gac ccc ctg ggg gta gta cgc ggg ggg cga gtt aat        243
Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn           
            65                  70                  75                    

acg cac gcc ggg gga act ggt cct gaa ggg tgc agg ccc ttt gcc aag        291
Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys           
        80                  85                  90                        

ttt att gtt taa                                                        303
Phe Ile Val                                                               
    95                                                                    


<210>  43
<211>  96
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  43

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Val 
                85                  90                  95      


<210>  44
<211>  96
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  44

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Val 
                85                  90                  95      


<210>  45
<211>  288
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(288)

<400>  45
acgcgtgcca cc atg gct ttc ttg tgg ctt ctc agt tgt tgg gcc ttg ttg       51
              Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu         
              1               5                   10                      

ggg acc act ttc gga tct gca gag gac gat tct gag agg gat cct ttg         99
Gly Thr Thr Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu           
    15                  20                  25                            

aat gtc ctt aag ccg agg gcc cgc atg acg cct gca cca gca tcc tgc        147
Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys           
30                  35                  40                  45            

agt caa gag ctc cct tca gca gaa gat aat agt cct atg gcg tcc gac        195
Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp           
                50                  55                  60                

ccc ctg ggg gta gta cgc ggg ggg cga gtt aat acg cac gcc ggg gga        243
Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly           
            65                  70                  75                    

act ggt cct gaa ggg tgc agg ccc ttt gcc aag ttt att gtt taa            288
Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Val                   
        80                  85                  90                        


<210>  46
<211>  91
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
            20                  25                  30          


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
        35                  40                  45              


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
    50                  55                  60                  


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
65                  70                  75                  80  


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Val 
                85                  90      


<210>  47
<211>  91
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  47

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
            20                  25                  30          


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
        35                  40                  45              


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
    50                  55                  60                  


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
65                  70                  75                  80  


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Val 
                85                  90      


<210>  48
<211>  2055
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(2055)

<400>  48
acgcgtgcca cc atg gct ttc ttg tgg ctt ctc agt tgt tgg gcc ttg ttg       51
              Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu         
              1               5                   10                      

ggg acc act ttc gga cga aga cac aca cgc tct gca gag gac gat tct         99
Gly Thr Thr Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser           
    15                  20                  25                            

gag agg gat cct ttg aat gtc ctt aag ccg agg gcc cgc atg acg cct        147
Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro           
30                  35                  40                  45            

gca cca gca tcc tgc agt caa gag ctc cct tca gca gaa gat aat agt        195
Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser           
                50                  55                  60                

cct atg gcg tcc gac ccc ctg ggg gta gta cgc ggg ggg cga gtt aat        243
Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn           
            65                  70                  75                    

acg cac gcc ggg gga act ggt cct gaa ggg tgc agg ccc ttt gcc aag        291
Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys           
        80                  85                  90                        

ttt att gat gct cat aaa tca gag gta gct cac cgc ttc aaa gac ctc        339
Phe Ile Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu           
    95                  100                 105                           

gga gag gag aac ttt aag gcc ctc gtc ctc atc gca ttt gca cag tat        387
Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr           
110                 115                 120                 125           

ttg caa caa tgt ccc ttt gag gat cat gtc aaa ttg gta aat gaa gtt        435
Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val           
                130                 135                 140               

act gag ttc gcg aag aca tgc gtg gct gac gag tcc gca gaa aac tgc        483
Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys           
            145                 150                 155                   

gac aag tcc ctt cat aca ctg ttt ggt gat aaa ctg tgc act gtc gct        531
Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala           
        160                 165                 170                       

act ctt aga gaa aca tat gga gag atg gct gac tgt tgt gcg aag caa        579
Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln           
    175                 180                 185                           

gag cca gaa cgg aat gaa tgt ttc ctt caa cat aaa gat gat aat ccg        627
Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro           
190                 195                 200                 205           

aat ttg cca cgc ctt gta cga cca gag gtg gat gtt atg tgc acc gcg        675
Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala           
                210                 215                 220               

ttt cat gac aat gag gaa acg ttc ctg aaa aaa tat ttg tat gag att        723
Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile           
            225                 230                 235                   

gct cgg aga cat cct tac ttt tac gca ccc gag ctc ctg ttc ttc gct        771
Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala           
        240                 245                 250                       

aag aga tac aag gca gcc ttt acg gaa tgc tgt cag gcc gcg gat aag        819
Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys           
    255                 260                 265                           

gcc gcc tgc ttg ctc ccc aag ctg gac gag ctg cga gat gag ggc aag        867
Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys           
270                 275                 280                 285           

gcg tcc tct gct aag caa cga ctc aaa tgc gcc agc ttg caa aag ttt        915
Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe           
                290                 295                 300               

ggc gaa aga gcg ttt aag gcc tgg gca gtg gcg cgc ctg agt cag cgg        963
Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg           
            305                 310                 315                   

ttc cct aag gcg gag ttt gcc gag gtc tca aaa ctg gtg aca gac ttg       1011
Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu           
        320                 325                 330                       

acg aag gta cat acc gag tgc tgc cac gga gat ctc ctg gag tgc gcg       1059
Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala           
    335                 340                 345                           

gat gat cgc gct gac ctc gcc aaa tat ata tgt gag aac cag gat tcc       1107
Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser           
350                 355                 360                 365           

att tcc tca aaa ctt aaa gag tgc tgc gaa aaa ccc ctt ctt gag aag       1155
Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys           
                370                 375                 380               

tca cac tgc att gca gag gtc gaa aac gac gaa atg cct gcc gat ctg       1203
Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu           
            385                 390                 395                   

cct tcc ctt gcg gct gac ttt gtg gag tct aag gac gtt tgc aaa aac       1251
Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn           
        400                 405                 410                       

tat gca gag gct aaa gac gta ttc ctg ggc atg ttt ctt tat gaa tac       1299
Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr           
    415                 420                 425                           

gcg cgg cga cat ccc gac tat tca gtc gta ctc ctg ctt cga ctg gcg       1347
Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala           
430                 435                 440                 445           

aaa act tac gaa act act ctc gag aaa tgc tgt gct gcc gcc gac cct       1395
Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro           
                450                 455                 460               

cat gag tgc tat gct aag gta ttt gat gaa ttc aaa ccg ttg gtt gag       1443
His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu           
            465                 470                 475                   

gaa ccg caa aac ttg atc aag cag aac tgt gaa ctt ttt gag cag ctg       1491
Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu           
        480                 485                 490                       

ggg gaa tat aaa ttc cag aat gca ttg ctt gta cga tac aca aag aaa       1539
Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys           
    495                 500                 505                           

gtt cca cag gtc tcc acc ccg aca ctt gtg gaa gtt agc agg aac ttg       1587
Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu           
510                 515                 520                 525           

gga aag gtc ggc agc aag tgt tgt aag cac cct gaa gct aag cga atg       1635
Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met           
                530                 535                 540               

cca tgc gcc gaa gat tac ctt tct gtg gtg ttg aac caa ctg tgc gtt       1683
Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val           
            545                 550                 555                   

ctt cac gaa aag acg ccc gta tct gat cgg gtg acg aaa tgc tgc aca       1731
Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr           
        560                 565                 570                       

gag tca ctt gtg aac aga cgc ccc tgc ttt agt gcg ctc gag gtg gac       1779
Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp           
    575                 580                 585                           

gaa acg tat gtc ccg aaa gag ttt aac gca gag aca ttc acg ttt cat       1827
Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His           
590                 595                 600                 605           

gcg gac atc tgt acc ctc tct gaa aag gag aga cag atc aaa aag cag       1875
Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln           
                610                 615                 620               

aca gcg ctg gtt gag ctt gtt aag cat aag ccg aag gcg aca aag gag       1923
Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu           
            625                 630                 635                   

caa ctg aaa gcg gtg atg gat gac ttc gcc gcg ttc gtt gaa aaa tgc       1971
Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys           
        640                 645                 650                       

tgc aaa gcc gac gat aag gaa acc tgt ttt gct gaa gaa ggt aaa aaa       2019
Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys           
    655                 660                 665                           

ctc gtt gct gcg agt cag gcc gcc ctg ggg ctg tga                       2055
Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu                               
670                 675                 680                               


<210>  49
<211>  680
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  49

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Asp 
                85                  90                  95      


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
            100                 105                 110         


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
        115                 120                 125             


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
    130                 135                 140                 


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
145                 150                 155                 160 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
                165                 170                 175     


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
            180                 185                 190         


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
        195                 200                 205             


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
    210                 215                 220                 


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
225                 230                 235                 240 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
                245                 250                 255     


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
            260                 265                 270         


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
        275                 280                 285             


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
    290                 295                 300                 


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
305                 310                 315                 320 


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
                325                 330                 335     


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
            340                 345                 350         


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
        355                 360                 365             


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
    370                 375                 380                 


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
385                 390                 395                 400 


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
                405                 410                 415     


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
            420                 425                 430         


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
        435                 440                 445             


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
    450                 455                 460                 


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
465                 470                 475                 480 


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
                485                 490                 495     


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
            500                 505                 510         


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
        515                 520                 525             


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
    530                 535                 540                 


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
545                 550                 555                 560 


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
                565                 570                 575     


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
            580                 585                 590         


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
        595                 600                 605             


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
    610                 615                 620                 


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
625                 630                 635                 640 


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
                645                 650                 655     


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
            660                 665                 670         


Ala Ser Gln Ala Ala Leu Gly Leu 
        675                 680 


<210>  50
<211>  680
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  50

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Asp 
                85                  90                  95      


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
            100                 105                 110         


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
        115                 120                 125             


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
    130                 135                 140                 


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
145                 150                 155                 160 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
                165                 170                 175     


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
            180                 185                 190         


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
        195                 200                 205             


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
    210                 215                 220                 


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
225                 230                 235                 240 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
                245                 250                 255     


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
            260                 265                 270         


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
        275                 280                 285             


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
    290                 295                 300                 


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
305                 310                 315                 320 


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
                325                 330                 335     


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
            340                 345                 350         


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
        355                 360                 365             


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
    370                 375                 380                 


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
385                 390                 395                 400 


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
                405                 410                 415     


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
            420                 425                 430         


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
        435                 440                 445             


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
    450                 455                 460                 


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
465                 470                 475                 480 


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
                485                 490                 495     


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
            500                 505                 510         


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
        515                 520                 525             


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
    530                 535                 540                 


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
545                 550                 555                 560 


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
                565                 570                 575     


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
            580                 585                 590         


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
        595                 600                 605             


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
    610                 615                 620                 


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
625                 630                 635                 640 


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
                645                 650                 655     


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
            660                 665                 670         


Ala Ser Gln Ala Ala Leu Gly Leu 
        675                 680 


<210>  51
<211>  2103
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(2103)

<400>  51
acgcgtgcca cc atg gct ttc ttg tgg ctt ctc agt tgt tgg gcc ttg ttg       51
              Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu         
              1               5                   10                      

ggg acc act ttc gga tct gca gag gac gat tct gag agg gat cct ttg         99
Gly Thr Thr Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu           
    15                  20                  25                            

aat gtc ctt aag ccg agg gcc cgc atg acg cct gca cca gca tcc tgc        147
Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys           
30                  35                  40                  45            

agt caa gag ctc cct tca gca gaa gat aat agt cct atg gcg tcc gac        195
Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp           
                50                  55                  60                

ccc ctg ggg gta gta cgc ggg ggg cga gtt aat acg cac gcc ggg gga        243
Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly           
            65                  70                  75                    

act ggt cct gaa ggg tgc agg ccc ttt gcc aag ttt att tca gtg tca        291
Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Ser Val Ser           
        80                  85                  90                        

caa acc tct aaa ctg aca cgc gcc gag acg gtc ttt ccg gat gtt gat        339
Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp           
    95                  100                 105                           

gga tca gat gct cat aaa tca gag gta gct cac cgc ttc aaa gac ctc        387
Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu           
110                 115                 120                 125           

gga gag gag aac ttt aag gcc ctc gtc ctc atc gca ttt gca cag tat        435
Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr           
                130                 135                 140               

ttg caa caa tgt ccc ttt gag gat cat gtc aaa ttg gta aat gaa gtt        483
Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val           
            145                 150                 155                   

act gag ttc gcg aag aca tgc gtg gct gac gag tcc gca gaa aac tgc        531
Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys           
        160                 165                 170                       

gac aag tcc ctt cat aca ctg ttt ggt gat aaa ctg tgc act gtc gct        579
Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala           
    175                 180                 185                           

act ctt aga gaa aca tat gga gag atg gct gac tgt tgt gcg aag caa        627
Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln           
190                 195                 200                 205           

gag cca gaa cgg aat gaa tgt ttc ctt caa cat aaa gat gat aat ccg        675
Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro           
                210                 215                 220               

aat ttg cca cgc ctt gta cga cca gag gtg gat gtt atg tgc acc gcg        723
Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala           
            225                 230                 235                   

ttt cat gac aat gag gaa acg ttc ctg aaa aaa tat ttg tat gag att        771
Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile           
        240                 245                 250                       

gct cgg aga cat cct tac ttt tac gca ccc gag ctc ctg ttc ttc gct        819
Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala           
    255                 260                 265                           

aag aga tac aag gca gcc ttt acg gaa tgc tgt cag gcc gcg gat aag        867
Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys           
270                 275                 280                 285           

gcc gcc tgc ttg ctc ccc aag ctg gac gag ctg cga gat gag ggc aag        915
Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys           
                290                 295                 300               

gcg tcc tct gct aag caa cga ctc aaa tgc gcc agc ttg caa aag ttt        963
Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe           
            305                 310                 315                   

ggc gaa aga gcg ttt aag gcc tgg gca gtg gcg cgc ctg agt cag cgg       1011
Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg           
        320                 325                 330                       

ttc cct aag gcg gag ttt gcc gag gtc tca aaa ctg gtg aca gac ttg       1059
Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu           
    335                 340                 345                           

acg aag gta cat acc gag tgc tgc cac gga gat ctc ctg gag tgc gcg       1107
Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala           
350                 355                 360                 365           

gat gat cgc gct gac ctc gcc aaa tat ata tgt gag aac cag gat tcc       1155
Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser           
                370                 375                 380               

att tcc tca aaa ctt aaa gag tgc tgc gaa aaa ccc ctt ctt gag aag       1203
Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys           
            385                 390                 395                   

tca cac tgc att gca gag gtc gaa aac gac gaa atg cct gcc gat ctg       1251
Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu           
        400                 405                 410                       

cct tcc ctt gcg gct gac ttt gtg gag tct aag gac gtt tgc aaa aac       1299
Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn           
    415                 420                 425                           

tat gca gag gct aaa gac gta ttc ctg ggc atg ttt ctt tat gaa tac       1347
Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr           
430                 435                 440                 445           

gcg cgg cga cat ccc gac tat tca gtc gta ctc ctg ctt cga ctg gcg       1395
Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala           
                450                 455                 460               

aaa act tac gaa act act ctc gag aaa tgc tgt gct gcc gcc gac cct       1443
Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro           
            465                 470                 475                   

cat gag tgc tat gct aag gta ttt gat gaa ttc aaa ccg ttg gtt gag       1491
His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu           
        480                 485                 490                       

gaa ccg caa aac ttg atc aag cag aac tgt gaa ctt ttt gag cag ctg       1539
Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu           
    495                 500                 505                           

ggg gaa tat aaa ttc cag aat gca ttg ctt gta cga tac aca aag aaa       1587
Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys           
510                 515                 520                 525           

gtt cca cag gtc tcc acc ccg aca ctt gtg gaa gtt agc agg aac ttg       1635
Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu           
                530                 535                 540               

gga aag gtc ggc agc aag tgt tgt aag cac cct gaa gct aag cga atg       1683
Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met           
            545                 550                 555                   

cca tgc gcc gaa gat tac ctt tct gtg gtg ttg aac caa ctg tgc gtt       1731
Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val           
        560                 565                 570                       

ctt cac gaa aag acg ccc gta tct gat cgg gtg acg aaa tgc tgc aca       1779
Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr           
    575                 580                 585                           

gag tca ctt gtg aac aga cgc ccc tgc ttt agt gcg ctc gag gtg gac       1827
Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp           
590                 595                 600                 605           

gaa acg tat gtc ccg aaa gag ttt aac gca gag aca ttc acg ttt cat       1875
Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His           
                610                 615                 620               

gcg gac atc tgt acc ctc tct gaa aag gag aga cag atc aaa aag cag       1923
Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln           
            625                 630                 635                   

aca gcg ctg gtt gag ctt gtt aag cat aag ccg aag gcg aca aag gag       1971
Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu           
        640                 645                 650                       

caa ctg aaa gcg gtg atg gat gac ttc gcc gcg ttc gtt gaa aaa tgc       2019
Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys           
    655                 660                 665                           

tgc aaa gcc gac gat aag gaa acc tgt ttt gct gaa gaa ggt aaa aaa       2067
Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys           
670                 675                 680                 685           

ctc gtt gct gcg agt cag gcc gcc ctg ggg ctg tga                       2103
Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu                               
                690                 695                                   


<210>  52
<211>  696
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
            20                  25                  30          


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
        35                  40                  45              


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
    50                  55                  60                  


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
65                  70                  75                  80  


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Ser Val Ser Gln Thr Ser 
                85                  90                  95      


Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp Gly Ser Asp 
            100                 105                 110         


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
        115                 120                 125             


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
    130                 135                 140                 


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
145                 150                 155                 160 


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
                165                 170                 175     


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
            180                 185                 190         


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
        195                 200                 205             


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
    210                 215                 220                 


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
225                 230                 235                 240 


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
                245                 250                 255     


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
            260                 265                 270         


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
        275                 280                 285             


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
    290                 295                 300                 


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
305                 310                 315                 320 


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
                325                 330                 335     


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
            340                 345                 350         


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
        355                 360                 365             


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
    370                 375                 380                 


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
385                 390                 395                 400 


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
                405                 410                 415     


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
            420                 425                 430         


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
        435                 440                 445             


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
    450                 455                 460                 


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
465                 470                 475                 480 


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
                485                 490                 495     


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
            500                 505                 510         


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
        515                 520                 525             


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
    530                 535                 540                 


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
545                 550                 555                 560 


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
                565                 570                 575     


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
            580                 585                 590         


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
        595                 600                 605             


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
    610                 615                 620                 


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
625                 630                 635                 640 


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
                645                 650                 655     


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
            660                 665                 670         


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
        675                 680                 685             


Ala Ser Gln Ala Ala Leu Gly Leu 
    690                 695     


<210>  53
<211>  696
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  53

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
            20                  25                  30          


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
        35                  40                  45              


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
    50                  55                  60                  


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
65                  70                  75                  80  


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Ser Val Ser Gln Thr Ser 
                85                  90                  95      


Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp Gly Ser Asp 
            100                 105                 110         


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
        115                 120                 125             


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
    130                 135                 140                 


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
145                 150                 155                 160 


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
                165                 170                 175     


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
            180                 185                 190         


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
        195                 200                 205             


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
    210                 215                 220                 


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
225                 230                 235                 240 


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
                245                 250                 255     


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
            260                 265                 270         


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
        275                 280                 285             


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
    290                 295                 300                 


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
305                 310                 315                 320 


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
                325                 330                 335     


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
            340                 345                 350         


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
        355                 360                 365             


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
    370                 375                 380                 


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
385                 390                 395                 400 


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
                405                 410                 415     


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
            420                 425                 430         


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
        435                 440                 445             


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
    450                 455                 460                 


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
465                 470                 475                 480 


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
                485                 490                 495     


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
            500                 505                 510         


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
        515                 520                 525             


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
    530                 535                 540                 


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
545                 550                 555                 560 


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
                565                 570                 575     


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
            580                 585                 590         


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
        595                 600                 605             


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
    610                 615                 620                 


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
625                 630                 635                 640 


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
                645                 650                 655     


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
            660                 665                 670         


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
        675                 680                 685             


Ala Ser Gln Ala Ala Leu Gly Leu 
    690                 695     


<210>  54
<211>  2040
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(2040)

<400>  54
acgcgtgcca cc atg gct ttc ttg tgg ctt ctc agt tgt tgg gcc ttg ttg       51
              Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu         
              1               5                   10                      

ggg acc act ttc gga tct gca gag gac gat tct gag agg gat cct ttg         99
Gly Thr Thr Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu           
    15                  20                  25                            

aat gtc ctt aag ccg agg gcc cgc atg acg cct gca cca gca tcc tgc        147
Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys           
30                  35                  40                  45            

agt caa gag ctc cct tca gca gaa gat aat agt cct atg gcg tcc gac        195
Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp           
                50                  55                  60                

ccc ctg ggg gta gta cgc ggg ggg cga gtt aat acg cac gcc ggg gga        243
Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly           
            65                  70                  75                    

act ggt cct gaa ggg tgc agg ccc ttt gcc aag ttt att gat gct cat        291
Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Asp Ala His           
        80                  85                  90                        

aaa tca gag gta gct cac cgc ttc aaa gac ctc gga gag gag aac ttt        339
Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe           
    95                  100                 105                           

aag gcc ctc gtc ctc atc gca ttt gca cag tat ttg caa caa tgt ccc        387
Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro           
110                 115                 120                 125           

ttt gag gat cat gtc aaa ttg gta aat gaa gtt act gag ttc gcg aag        435
Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys           
                130                 135                 140               

aca tgc gtg gct gac gag tcc gca gaa aac tgc gac aag tcc ctt cat        483
Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His           
            145                 150                 155                   

aca ctg ttt ggt gat aaa ctg tgc act gtc gct act ctt aga gaa aca        531
Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr           
        160                 165                 170                       

tat gga gag atg gct gac tgt tgt gcg aag caa gag cca gaa cgg aat        579
Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn           
    175                 180                 185                           

gaa tgt ttc ctt caa cat aaa gat gat aat ccg aat ttg cca cgc ctt        627
Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu           
190                 195                 200                 205           

gta cga cca gag gtg gat gtt atg tgc acc gcg ttt cat gac aat gag        675
Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu           
                210                 215                 220               

gaa acg ttc ctg aaa aaa tat ttg tat gag att gct cgg aga cat cct        723
Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro           
            225                 230                 235                   

tac ttt tac gca ccc gag ctc ctg ttc ttc gct aag aga tac aag gca        771
Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala           
        240                 245                 250                       

gcc ttt acg gaa tgc tgt cag gcc gcg gat aag gcc gcc tgc ttg ctc        819
Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu           
    255                 260                 265                           

ccc aag ctg gac gag ctg cga gat gag ggc aag gcg tcc tct gct aag        867
Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys           
270                 275                 280                 285           

caa cga ctc aaa tgc gcc agc ttg caa aag ttt ggc gaa aga gcg ttt        915
Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe           
                290                 295                 300               

aag gcc tgg gca gtg gcg cgc ctg agt cag cgg ttc cct aag gcg gag        963
Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu           
            305                 310                 315                   

ttt gcc gag gtc tca aaa ctg gtg aca gac ttg acg aag gta cat acc       1011
Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr           
        320                 325                 330                       

gag tgc tgc cac gga gat ctc ctg gag tgc gcg gat gat cgc gct gac       1059
Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp           
    335                 340                 345                           

ctc gcc aaa tat ata tgt gag aac cag gat tcc att tcc tca aaa ctt       1107
Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu           
350                 355                 360                 365           

aaa gag tgc tgc gaa aaa ccc ctt ctt gag aag tca cac tgc att gca       1155
Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala           
                370                 375                 380               

gag gtc gaa aac gac gaa atg cct gcc gat ctg cct tcc ctt gcg gct       1203
Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala           
            385                 390                 395                   

gac ttt gtg gag tct aag gac gtt tgc aaa aac tat gca gag gct aaa       1251
Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys           
        400                 405                 410                       

gac gta ttc ctg ggc atg ttt ctt tat gaa tac gcg cgg cga cat ccc       1299
Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro           
    415                 420                 425                           

gac tat tca gtc gta ctc ctg ctt cga ctg gcg aaa act tac gaa act       1347
Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr           
430                 435                 440                 445           

act ctc gag aaa tgc tgt gct gcc gcc gac cct cat gag tgc tat gct       1395
Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala           
                450                 455                 460               

aag gta ttt gat gaa ttc aaa ccg ttg gtt gag gaa ccg caa aac ttg       1443
Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu           
            465                 470                 475                   

atc aag cag aac tgt gaa ctt ttt gag cag ctg ggg gaa tat aaa ttc       1491
Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe           
        480                 485                 490                       

cag aat gca ttg ctt gta cga tac aca aag aaa gtt cca cag gtc tcc       1539
Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser           
    495                 500                 505                           

acc ccg aca ctt gtg gaa gtt agc agg aac ttg gga aag gtc ggc agc       1587
Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser           
510                 515                 520                 525           

aag tgt tgt aag cac cct gaa gct aag cga atg cca tgc gcc gaa gat       1635
Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp           
                530                 535                 540               

tac ctt tct gtg gtg ttg aac caa ctg tgc gtt ctt cac gaa aag acg       1683
Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr           
            545                 550                 555                   

ccc gta tct gat cgg gtg acg aaa tgc tgc aca gag tca ctt gtg aac       1731
Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn           
        560                 565                 570                       

aga cgc ccc tgc ttt agt gcg ctc gag gtg gac gaa acg tat gtc ccg       1779
Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro           
    575                 580                 585                           

aaa gag ttt aac gca gag aca ttc acg ttt cat gcg gac atc tgt acc       1827
Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr           
590                 595                 600                 605           

ctc tct gaa aag gag aga cag atc aaa aag cag aca gcg ctg gtt gag       1875
Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu           
                610                 615                 620               

ctt gtt aag cat aag ccg aag gcg aca aag gag caa ctg aaa gcg gtg       1923
Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val           
            625                 630                 635                   

atg gat gac ttc gcc gcg ttc gtt gaa aaa tgc tgc aaa gcc gac gat       1971
Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp           
        640                 645                 650                       

aag gaa acc tgt ttt gct gaa gaa ggt aaa aaa ctc gtt gct gcg agt       2019
Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser           
    655                 660                 665                           

cag gcc gcc ctg ggg ctg tga                                           2040
Gln Ala Ala Leu Gly Leu                                                   
670                 675                                                   


<210>  55
<211>  675
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  55

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
            20                  25                  30          


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
        35                  40                  45              


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
    50                  55                  60                  


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
65                  70                  75                  80  


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Asp Ala His Lys Ser Glu 
                85                  90                  95      


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            100                 105                 110         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        115                 120                 125             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    130                 135                 140                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
145                 150                 155                 160 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                165                 170                 175     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            180                 185                 190         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        195                 200                 205             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    210                 215                 220                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                245                 250                 255     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            260                 265                 270         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        275                 280                 285             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    290                 295                 300                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
305                 310                 315                 320 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                325                 330                 335     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            340                 345                 350         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        355                 360                 365             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    370                 375                 380                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
385                 390                 395                 400 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                405                 410                 415     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            420                 425                 430         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        435                 440                 445             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    450                 455                 460                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
465                 470                 475                 480 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                485                 490                 495     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            500                 505                 510         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        515                 520                 525             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    530                 535                 540                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
545                 550                 555                 560 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                565                 570                 575     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            580                 585                 590         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        595                 600                 605             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    610                 615                 620                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
625                 630                 635                 640 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                645                 650                 655     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            660                 665                 670         


Leu Gly Leu 
        675 


<210>  56
<211>  675
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  56

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
            20                  25                  30          


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
        35                  40                  45              


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
    50                  55                  60                  


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
65                  70                  75                  80  


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Asp Ala His Lys Ser Glu 
                85                  90                  95      


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            100                 105                 110         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        115                 120                 125             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    130                 135                 140                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
145                 150                 155                 160 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                165                 170                 175     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            180                 185                 190         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        195                 200                 205             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    210                 215                 220                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                245                 250                 255     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            260                 265                 270         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        275                 280                 285             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    290                 295                 300                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
305                 310                 315                 320 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                325                 330                 335     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            340                 345                 350         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        355                 360                 365             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    370                 375                 380                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
385                 390                 395                 400 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                405                 410                 415     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            420                 425                 430         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        435                 440                 445             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    450                 455                 460                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
465                 470                 475                 480 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                485                 490                 495     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            500                 505                 510         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        515                 520                 525             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    530                 535                 540                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
545                 550                 555                 560 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                565                 570                 575     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            580                 585                 590         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        595                 600                 605             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    610                 615                 620                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
625                 630                 635                 640 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                645                 650                 655     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            660                 665                 670         


Leu Gly Leu 
        675 


<210>  57
<211>  2118
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  CDS
<222>  (13)..(2118)

<400>  57
acgcgtgcca cc atg gct ttc ttg tgg ctt ctc agt tgt tgg gcc ttg ttg       51
              Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu         
              1               5                   10                      

ggg acc act ttc gga cga aga cac aca cgc tct gca gag gac gat tct         99
Gly Thr Thr Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser           
    15                  20                  25                            

gag agg gat cct ttg aat gtc ctt aag ccg agg gcc cgc atg acg cct        147
Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro           
30                  35                  40                  45            

gca cca gca tcc tgc agt caa gag ctc cct tca gca gaa gat aat agt        195
Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser           
                50                  55                  60                

cct atg gcg tcc gac ccc ctg ggg gta gta cgc ggg ggg cga gtt aat        243
Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn           
            65                  70                  75                    

acg cac gcc ggg gga act ggt cct gaa ggg tgc agg ccc ttt gcc aag        291
Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys           
        80                  85                  90                        

ttt att tca gtg tca caa acc tct aaa ctg aca cgc gcc gag acg gtc        339
Phe Ile Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val           
    95                  100                 105                           

ttt ccg gat gtt gat gga tca gat gct cat aaa tca gag gta gct cac        387
Phe Pro Asp Val Asp Gly Ser Asp Ala His Lys Ser Glu Val Ala His           
110                 115                 120                 125           

cgc ttc aaa gac ctc gga gag gag aac ttt aag gcc ctc gtc ctc atc        435
Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile           
                130                 135                 140               

gca ttt gca cag tat ttg caa caa tgt ccc ttt gag gat cat gtc aaa        483
Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys           
            145                 150                 155                   

ttg gta aat gaa gtt act gag ttc gcg aag aca tgc gtg gct gac gag        531
Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu           
        160                 165                 170                       

tcc gca gaa aac tgc gac aag tcc ctt cat aca ctg ttt ggt gat aaa        579
Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys           
    175                 180                 185                           

ctg tgc act gtc gct act ctt aga gaa aca tat gga gag atg gct gac        627
Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp           
190                 195                 200                 205           

tgt tgt gcg aag caa gag cca gaa cgg aat gaa tgt ttc ctt caa cat        675
Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His           
                210                 215                 220               

aaa gat gat aat ccg aat ttg cca cgc ctt gta cga cca gag gtg gat        723
Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp           
            225                 230                 235                   

gtt atg tgc acc gcg ttt cat gac aat gag gaa acg ttc ctg aaa aaa        771
Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys           
        240                 245                 250                       

tat ttg tat gag att gct cgg aga cat cct tac ttt tac gca ccc gag        819
Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu           
    255                 260                 265                           

ctc ctg ttc ttc gct aag aga tac aag gca gcc ttt acg gaa tgc tgt        867
Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys           
270                 275                 280                 285           

cag gcc gcg gat aag gcc gcc tgc ttg ctc ccc aag ctg gac gag ctg        915
Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu           
                290                 295                 300               

cga gat gag ggc aag gcg tcc tct gct aag caa cga ctc aaa tgc gcc        963
Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala           
            305                 310                 315                   

agc ttg caa aag ttt ggc gaa aga gcg ttt aag gcc tgg gca gtg gcg       1011
Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala           
        320                 325                 330                       

cgc ctg agt cag cgg ttc cct aag gcg gag ttt gcc gag gtc tca aaa       1059
Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys           
    335                 340                 345                           

ctg gtg aca gac ttg acg aag gta cat acc gag tgc tgc cac gga gat       1107
Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp           
350                 355                 360                 365           

ctc ctg gag tgc gcg gat gat cgc gct gac ctc gcc aaa tat ata tgt       1155
Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys           
                370                 375                 380               

gag aac cag gat tcc att tcc tca aaa ctt aaa gag tgc tgc gaa aaa       1203
Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys           
            385                 390                 395                   

ccc ctt ctt gag aag tca cac tgc att gca gag gtc gaa aac gac gaa       1251
Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu           
        400                 405                 410                       

atg cct gcc gat ctg cct tcc ctt gcg gct gac ttt gtg gag tct aag       1299
Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys           
    415                 420                 425                           

gac gtt tgc aaa aac tat gca gag gct aaa gac gta ttc ctg ggc atg       1347
Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met           
430                 435                 440                 445           

ttt ctt tat gaa tac gcg cgg cga cat ccc gac tat tca gtc gta ctc       1395
Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu           
                450                 455                 460               

ctg ctt cga ctg gcg aaa act tac gaa act act ctc gag aaa tgc tgt       1443
Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys           
            465                 470                 475                   

gct gcc gcc gac cct cat gag tgc tat gct aag gta ttt gat gaa ttc       1491
Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe           
        480                 485                 490                       

aaa ccg ttg gtt gag gaa ccg caa aac ttg atc aag cag aac tgt gaa       1539
Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu           
    495                 500                 505                           

ctt ttt gag cag ctg ggg gaa tat aaa ttc cag aat gca ttg ctt gta       1587
Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val           
510                 515                 520                 525           

cga tac aca aag aaa gtt cca cag gtc tcc acc ccg aca ctt gtg gaa       1635
Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu           
                530                 535                 540               

gtt agc agg aac ttg gga aag gtc ggc agc aag tgt tgt aag cac cct       1683
Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro           
            545                 550                 555                   

gaa gct aag cga atg cca tgc gcc gaa gat tac ctt tct gtg gtg ttg       1731
Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu           
        560                 565                 570                       

aac caa ctg tgc gtt ctt cac gaa aag acg ccc gta tct gat cgg gtg       1779
Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val           
    575                 580                 585                           

acg aaa tgc tgc aca gag tca ctt gtg aac aga cgc ccc tgc ttt agt       1827
Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser           
590                 595                 600                 605           

gcg ctc gag gtg gac gaa acg tat gtc ccg aaa gag ttt aac gca gag       1875
Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu           
                610                 615                 620               

aca ttc acg ttt cat gcg gac atc tgt acc ctc tct gaa aag gag aga       1923
Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg           
            625                 630                 635                   

cag atc aaa aag cag aca gcg ctg gtt gag ctt gtt aag cat aag ccg       1971
Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro           
        640                 645                 650                       

aag gcg aca aag gag caa ctg aaa gcg gtg atg gat gac ttc gcc gcg       2019
Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala           
    655                 660                 665                           

ttc gtt gaa aaa tgc tgc aaa gcc gac gat aag gaa acc tgt ttt gct       2067
Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala           
670                 675                 680                 685           

gaa gaa ggt aaa aaa ctc gtt gct gcg agt cag gcc gcc ctg ggg ctg       2115
Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu           
                690                 695                 700               

tga                                                                   2118


<210>  58
<211>  701
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Arg His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp 
            20                  25                  30          


Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala 
        35                  40                  45              


Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala 
    50                  55                  60                  


Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Ser 
                85                  90                  95      


Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
            100                 105                 110         


Val Asp Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
        115                 120                 125             


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
    130                 135                 140                 


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
145                 150                 155                 160 


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
                165                 170                 175     


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
            180                 185                 190         


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
        195                 200                 205             


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
    210                 215                 220                 


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
225                 230                 235                 240 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
                245                 250                 255     


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
            260                 265                 270         


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
        275                 280                 285             


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
    290                 295                 300                 


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
305                 310                 315                 320 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
                325                 330                 335     


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
            340                 345                 350         


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
        355                 360                 365             


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
    370                 375                 380                 


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
385                 390                 395                 400 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
                405                 410                 415     


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
            420                 425                 430         


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
        435                 440                 445             


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
    450                 455                 460                 


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
                485                 490                 495     


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
            500                 505                 510         


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
        515                 520                 525             


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
    530                 535                 540                 


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
545                 550                 555                 560 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
                565                 570                 575     


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
            580                 585                 590         


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
        595                 600                 605             


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
    610                 615                 620                 


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
625                 630                 635                 640 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
                645                 650                 655     


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
            660                 665                 670         


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
        675                 680                 685             


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    690                 695                 700     


