                         SEQUENCE LISTING

<110>  Boehringer Ingelheim Vetmedica (China) Co. Ltd.
 
<120>  CSFV subunit vaccine

<130>  P20193024

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B8 epitope for GD18 or QZ07 or GD191

<400>  1

Ser Thr Asn Glu Ile Gly Pro Leu Gly Ala Glu Gly 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B8 epitope for C strain

<400>  2

Ser Thr Asp Glu Ile Gly Leu Leu Gly Ala Gly Gly 
1               5                   10          


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  3

Ser Phe Gly Met His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  4

Tyr Ile Ser Ser Asp Ser Phe Thr Ile Tyr Tyr Ala Asp Thr Met Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  5

Gly Asp Leu Pro Phe Ala Tyr 
1               5           


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  6

Lys Ala Ser Gln Ala Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  7

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  8

His Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  9
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of heavy chain of mAb 6B8

<400>  9

Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Asp Ser Phe Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Asp Leu Pro Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala 
    130                 135 


<210>  10
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region of light chain of mAb 6B8

<400>  10

Met Gly Ile Lys Met Glu Thr His Ser Gln Val Phe Val Tyr Met Leu 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His 
            20                  25                  30          


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys 
        35                  40                  45              


Ala Ser Gln Ala Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            100                 105                 110         


His Gln Tyr Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys 
    130     


<210>  11
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QZ07-E2

<400>  11

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Ile Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  12
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD18-E2

<400>  12

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  13
<211>  3898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of QZ07

<400>  13

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Met Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Gly Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Ala Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Thr Gly Asp Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Ala Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys His Gly Trp Cys Asn Trp Tyr 
            340                 345                 350         


Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu 
        355                 360                 365             


Thr Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp 
    370                 375                 380                 


Lys Asn Thr Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr 
385                 390                 395                 400 


Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr 
                405                 410                 415     


Val Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu 
            420                 425                 430         


Tyr Gly Asp His Glu Cys Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr 
        435                 440                 445             


Leu Leu Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala 
    450                 455                 460                 


Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Arg Thr Thr Gly Lys 
465                 470                 475                 480 


Lys Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser 
                485                 490                 495     


Pro Tyr Cys Asn Val Thr Arg Lys Ile Gly Tyr Ile Trp Tyr Thr Asn 
            500                 505                 510         


Asn Cys Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro 
        515                 520                 525             


Gly Lys Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met 
    530                 535                 540                 


Gly Gly His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Val Leu Ser 
545                 550                 555                 560 


Asp Phe Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr 
                565                 570                 575     


Ala Ile Pro Gln Ser Arg Asp Glu Pro Glu Val Cys Asp Thr Asn Gln 
            580                 585                 590         


Leu Asn Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser 
        595                 600                 605             


Val Trp Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro 
    610                 615                 620                 


Tyr Glu Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile 
625                 630                 635                 640 


Lys Leu Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser 
                645                 650                 655     


Ala Ser Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly 
            660                 665                 670         


Gln Val Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln 
        675                 680                 685             


Gly Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr 
    690                 695                 700                 


Asn Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys 
705                 710                 715                 720 


Glu Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile 
                725                 730                 735     


Cys Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg 
            740                 745                 750         


Arg Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr 
        755                 760                 765             


Phe Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly 
    770                 775                 780                 


Asp Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val 
785                 790                 795                 800 


Lys Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu 
                805                 810                 815     


Val Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser 
            820                 825                 830         


Pro Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys 
        835                 840                 845             


Pro Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu 
    850                 855                 860                 


Asp Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly 
865                 870                 875                 880 


Asn Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys 
                885                 890                 895     


Gly Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly 
            900                 905                 910         


Lys Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr 
        915                 920                 925             


Asp Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu 
    930                 935                 940                 


Cys Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg 
945                 950                 955                 960 


Leu Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly 
                965                 970                 975     


Pro Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg 
            980                 985                 990         


Asn Lys Tyr Tyr Glu Pro Arg Asp  Ser Tyr Phe Gln Gln  Tyr Met Leu 
        995                 1000                 1005             


Lys Gly  Glu Tyr Gln Tyr Trp  Phe Asp Leu Asp Val  Thr Asp His 
    1010                 1015                 1020             


His Thr  Asp Tyr Phe Ala Glu  Phe Val Val Leu Val  Val Val Ala 
    1025                 1030                 1035             


Leu Leu  Gly Gly Arg Tyr Val  Leu Trp Leu Ile Val  Thr Tyr Val 
    1040                 1045                 1050             


Ile Leu  Thr Glu Gln Leu Ala  Ala Gly Leu Gln Leu  Gly Gln Gly 
    1055                 1060                 1065             


Glu Val  Val Leu Ile Gly Asn  Leu Ile Thr His Thr  Asp Asn Glu 
    1070                 1075                 1080             


Val Val  Val Tyr Phe Leu Leu  Leu Tyr Leu Ile Ile  Arg Asp Glu 
    1085                 1090                 1095             


Pro Ile  Lys Lys Trp Ile Leu  Leu Leu Phe His Ala  Met Thr Asn 
    1100                 1105                 1110             


Asn Pro  Val Lys Thr Met Thr  Val Ala Leu Leu Met  Ile Ser Gly 
    1115                 1120                 1125             


Val Ala  Lys Gly Gly Lys Thr  Asp Gly Gly Trp Gln  Arg Gln Pro 
    1130                 1135                 1140             


Glu Thr  Asn Phe Asp Ile Gln  Leu Ala Leu Ala Val  Ile Val Val 
    1145                 1150                 1155             


Val Val  Met Leu Leu Ala Lys  Arg Asp Pro Thr Thr  Phe Pro Leu 
    1160                 1165                 1170             


Val Ile  Thr Val Ala Thr Leu  Arg Thr Ala Lys Ile  Thr Asn Gly 
    1175                 1180                 1185             


Phe Ser  Thr Asp Leu Ala Ile  Ala Thr Val Ser Ala  Ala Leu Leu 
    1190                 1195                 1200             


Thr Trp  Thr Tyr Ile Ser Asp  Tyr Tyr Lys Tyr Lys  Thr Trp Leu 
    1205                 1210                 1215             


Gln Tyr  Leu Ile Ser Thr Val  Thr Gly Ile Phe Leu  Ile Arg Val 
    1220                 1225                 1230             


Leu Lys  Gly Ile Gly Glu Leu  Asp Met His Ala Pro  Thr Leu Pro 
    1235                 1240                 1245             


Ser His  Arg Pro Leu Phe Tyr  Ile Leu Val Tyr Leu  Ile Ser Thr 
    1250                 1255                 1260             


Ala Val  Val Thr Arg Trp Asn  Leu Asp Val Ala Gly  Leu Leu Leu 
    1265                 1270                 1275             


Gln Cys  Val Pro Thr Leu Leu  Met Val Phe Thr Met  Trp Ala Asp 
    1280                 1285                 1290             


Ile Leu  Thr Leu Ile Leu Val  Leu Pro Thr Tyr Glu  Leu Ala Lys 
    1295                 1300                 1305             


Leu Tyr  Tyr Leu Lys Glu Val  Lys Ile Gly Thr Glu  Arg Gly Trp 
    1310                 1315                 1320             


Leu Trp  Lys Thr Asn Tyr Lys  Arg Val Asn Asp Ile  Tyr Glu Val 
    1325                 1330                 1335             


Asp Gln  Ala Gly Glu Gly Val  Tyr Leu Phe Pro Ser  Lys Gln Lys 
    1340                 1345                 1350             


Thr Ser  Ala Ile Thr Ser Thr  Met Leu Pro Leu Ile  Lys Ala Ile 
    1355                 1360                 1365             


Leu Ile  Ser Cys Ile Ser Asn  Lys Trp Gln Leu Ile  Tyr Leu Leu 
    1370                 1375                 1380             


Tyr Leu  Ile Phe Glu Val Ser  Tyr Tyr Leu His Lys  Lys Val Ile 
    1385                 1390                 1395             


Asp Glu  Ile Ala Gly Gly Thr  Asn Phe Val Ser Arg  Leu Val Ala 
    1400                 1405                 1410             


Ala Leu  Ile Glu Val Asn Trp  Ala Phe Asp Asn Glu  Glu Val Lys 
    1415                 1420                 1425             


Gly Leu  Lys Lys Phe Phe Leu  Leu Ser Ser Arg Val  Lys Glu Leu 
    1430                 1435                 1440             


Val Ile  Lys His Lys Val Arg  Asn Glu Val Val Ala  Arg Trp Phe 
    1445                 1450                 1455             


Gly Asp  Glu Glu Ile Tyr Gly  Met Pro Lys Leu Ile  Gly Leu Val 
    1460                 1465                 1470             


Lys Ala  Ala Thr Leu Ser Lys  Asn Lys His Cys Ile  Leu Cys Thr 
    1475                 1480                 1485             


Val Cys  Glu Asp Arg Asp Trp  Arg Gly Glu Thr Cys  Pro Lys Cys 
    1490                 1495                 1500             


Gly Arg  Phe Gly Pro Pro Val  Ile Cys Gly Met Thr  Leu Ala Asp 
    1505                 1510                 1515             


Phe Glu  Glu Lys His Tyr Lys  Arg Ile Phe Ile Arg  Glu Asp Gln 
    1520                 1525                 1530             


Ser Asp  Gly Pro Leu Arg Glu  Glu Arg Ala Gly Tyr  Leu Gln Tyr 
    1535                 1540                 1545             


Arg Ala  Arg Gly Gln Leu Phe  Leu Arg Asn Leu Pro  Val Leu Ala 
    1550                 1555                 1560             


Thr Lys  Val Lys Met Leu Leu  Val Gly Asn Leu Gly  Thr Glu Val 
    1565                 1570                 1575             


Gly Asp  Leu Glu His Leu Gly  Trp Val Leu Arg Gly  Pro Ala Val 
    1580                 1585                 1590             


Cys Lys  Lys Val Thr Glu His  Glu Lys Cys Ala Thr  Ser Ile Met 
    1595                 1600                 1605             


Asp Lys  Leu Thr Ala Phe Phe  Gly Val Met Pro Arg  Gly Thr Thr 
    1610                 1615                 1620             


Pro Arg  Ala Pro Val Arg Phe  Pro Thr Ser Leu Leu  Lys Ile Arg 
    1625                 1630                 1635             


Arg Gly  Leu Glu Thr Gly Trp  Ala Tyr Thr His Gln  Gly Gly Ile 
    1640                 1645                 1650             


Ser Ser  Val Asp His Val Thr  Cys Gly Lys Asp Leu  Leu Val Cys 
    1655                 1660                 1665             


Asp Thr  Met Gly Arg Thr Arg  Val Val Cys Gln Ser  Asn Asn Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Ser Glu Tyr  Gly Val Lys Thr Asp  Ser Gly Cys 
    1685                 1690                 1695             


Pro Glu  Gly Ala Arg Cys Tyr  Val Phe Asn Pro Glu  Ala Val Asn 
    1700                 1705                 1710             


Ile Ser  Gly Thr Lys Gly Ala  Met Val His Leu Gln  Lys Thr Gly 
    1715                 1720                 1725             


Gly Glu  Phe Thr Cys Val Thr  Ala Ser Gly Thr Pro  Ala Phe Phe 
    1730                 1735                 1740             


Asp Leu  Lys Asn Leu Lys Gly  Trp Ser Gly Leu Pro  Ile Phe Glu 
    1745                 1750                 1755             


Ala Ser  Ser Gly Arg Val Val  Gly Arg Val Lys Val  Gly Lys Asn 
    1760                 1765                 1770             


Asp Asp  Ser Lys Pro Thr Lys  Leu Met Ser Gly Ile  Gln Thr Val 
    1775                 1780                 1785             


Ser Lys  Ser Ala Thr Asp Leu  Thr Glu Met Val Lys  Lys Ile Thr 
    1790                 1795                 1800             


Thr Met  Asn Arg Gly Glu Phe  Arg Gln Ile Thr Leu  Ala Thr Gly 
    1805                 1810                 1815             


Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Ser Val Ile  Glu Glu Ile 
    1820                 1825                 1830             


Gly Arg  His Lys Arg Val Leu  Val Leu Ile Pro Leu  Arg Ala Ala 
    1835                 1840                 1845             


Ala Glu  Ser Val Tyr Gln Tyr  Met Arg Gln Lys His  Pro Ser Ile 
    1850                 1855                 1860             


Ala Phe  Asn Leu Arg Ile Gly  Glu Met Lys Glu Gly  His Met Ala 
    1865                 1870                 1875             


Thr Gly  Ile Thr Tyr Ala Ser  Tyr Gly Tyr Phe Cys  Gln Met Pro 
    1880                 1885                 1890             


Gln Pro  Lys Leu Arg Ala Ala  Met Val Glu Tyr Ser  Tyr Ile Phe 
    1895                 1900                 1905             


Leu Asp  Glu Tyr His Cys Ala  Thr Pro Glu Gln Leu  Ala Ile Met 
    1910                 1915                 1920             


Gly Lys  Ile His Arg Phe Ser  Glu Asn Leu Arg Val  Val Ala Met 
    1925                 1930                 1935             


Thr Ala  Thr Pro Ala Gly Thr  Val Thr Thr Thr Gly  Gln Lys His 
    1940                 1945                 1950             


Pro Ile  Glu Glu Phe Ile Ala  Pro Glu Val Met Lys  Gly Glu Asp 
    1955                 1960                 1965             


Leu Gly  Ser Glu Tyr Leu Asp  Ile Ala Gly Leu Lys  Ile Pro Val 
    1970                 1975                 1980             


Glu Glu  Met Lys Asn Asn Met  Leu Val Phe Val Pro  Thr Arg Asn 
    1985                 1990                 1995             


Met Ala  Val Glu Ala Ala Lys  Lys Leu Lys Ala Lys  Gly Tyr Asn 
    2000                 2005                 2010             


Ser Gly  Tyr Tyr Tyr Ser Gly  Glu Asp Pro Ser Asn  Leu Arg Val 
    2015                 2020                 2025             


Val Thr  Ser Gln Ser Pro Tyr  Val Val Val Ala Thr  Asn Ala Ile 
    2030                 2035                 2040             


Glu Ser  Gly Val Thr Leu Pro  Asp Leu Asp Val Val  Val Asp Thr 
    2045                 2050                 2055             


Gly Leu  Lys Cys Glu Lys Arg  Ile Arg Leu Ser Pro  Lys Met Pro 
    2060                 2065                 2070             


Phe Ile  Val Thr Gly Leu Lys  Arg Met Ala Val Thr  Ile Gly Glu 
    2075                 2080                 2085             


Gln Ala  Gln Arg Arg Gly Arg  Val Gly Arg Val Lys  Pro Gly Arg 
    2090                 2095                 2100             


Tyr Tyr  Arg Ser Gln Glu Thr  Pro Val Gly Ser Lys  Asp Tyr His 
    2105                 2110                 2115             


Tyr Asp  Leu Leu Gln Ala Gln  Arg Tyr Gly Ile Glu  Asp Gly Ile 
    2120                 2125                 2130             


Asn Ile  Thr Lys Ser Phe Arg  Glu Met Asn Tyr Asp  Trp Ser Leu 
    2135                 2140                 2145             


Tyr Glu  Glu Asp Ser Leu Met  Ile Thr Gln Leu Glu  Ile Leu Asn 
    2150                 2155                 2160             


Asn Leu  Leu Ile Ser Glu Glu  Leu Pro Val Ala Val  Lys Asn Ile 
    2165                 2170                 2175             


Met Ala  Arg Thr Asp His Pro  Glu Pro Ile Gln Leu  Ala Tyr Asn 
    2180                 2185                 2190             


Ser Tyr  Glu Thr Gln Val Pro  Val Leu Phe Pro Lys  Ile Arg Asn 
    2195                 2200                 2205             


Gly Glu  Val Thr Asp Thr Tyr  Asp Thr Tyr Thr Phe  Ile Asn Ala 
    2210                 2215                 2220             


Arg Lys  Leu Gly Asp Asp Val  Pro Pro Tyr Val Tyr  Ala Thr Glu 
    2225                 2230                 2235             


Asp Glu  Asp Leu Ala Val Glu  Leu Leu Gly Leu Asp  Trp Pro Asp 
    2240                 2245                 2250             


Pro Gly  Asn Gln Gly Thr Val  Glu Ala Gly Arg Ala  Leu Lys Gln 
    2255                 2260                 2265             


Val Val  Gly Leu Ser Thr Ala  Glu Asn Ala Leu Leu  Val Ala Leu 
    2270                 2275                 2280             


Phe Gly  Tyr Val Gly Tyr Gln  Ala Leu Ser Lys Arg  His Ile Pro 
    2285                 2290                 2295             


Val Val  Thr Asp Ile Tyr Ser  Val Glu Asp His Arg  Leu Glu Asp 
    2300                 2305                 2310             


Thr Thr  His Leu Gln Tyr Ala  Pro Asn Ala Ile Lys  Thr Glu Gly 
    2315                 2320                 2325             


Lys Glu  Thr Glu Leu Lys Glu  Leu Ala Gln Gly Asp  Val Gln Arg 
    2330                 2335                 2340             


Cys Val  Glu Ala Met Thr Asn  Tyr Ala Arg Gly Gly  Ile Gln Phe 
    2345                 2350                 2355             


Met Lys  Ser Gln Ala Leu Gln  Val Arg Glu Thr Pro  Thr Tyr Lys 
    2360                 2365                 2370             


Glu Thr  Met Asn Thr Val Ala  Asp Tyr Val Lys Lys  Phe Ile Glu 
    2375                 2380                 2385             


Ala Leu  Ser Asp Ser Lys Glu  Asp Ile Leu Lys Tyr  Gly Leu Trp 
    2390                 2395                 2400             


Gly Val  His Thr Ala Leu Tyr  Lys Ser Ile Gly Ala  Arg Leu Gly 
    2405                 2410                 2415             


His Glu  Thr Ala Phe Ala Thr  Leu Ala Val Lys Trp  Leu Ala Phe 
    2420                 2425                 2430             


Gly Gly  Glu Ser Ile Ala Asp  His Ile Lys Gln Ala  Ala Thr Asp 
    2435                 2440                 2445             


Leu Val  Val Tyr Tyr Ile Ile  Asn Arg Pro Gln Phe  Pro Gly Asp 
    2450                 2455                 2460             


Thr Glu  Thr Gln Gln Glu Gly  Arg Asn Phe Val Ala  Ser Leu Leu 
    2465                 2470                 2475             


Val Ser  Ala Leu Ala Thr Tyr  Thr Tyr Lys Ser Trp  Asn Tyr Asn 
    2480                 2485                 2490             


Asn Leu  Ser Lys Ile Val Glu  Pro Ala Leu Ala Thr  Leu Pro Tyr 
    2495                 2500                 2505             


Ala Ala  Lys Ala Leu Lys Leu  Phe Ala Pro Thr Arg  Leu Glu Ser 
    2510                 2515                 2520             


Val Val  Ile Leu Ser Thr Ala  Ile Tyr Lys Thr Tyr  Leu Ser Ile 
    2525                 2530                 2535             


Arg Arg  Gly Lys Ser Asp Gly  Leu Leu Gly Thr Gly  Val Ser Ala 
    2540                 2545                 2550             


Ala Met  Glu Ile Met Ser Gln  Asn Pro Val Ser Val  Gly Ile Ala 
    2555                 2560                 2565             


Val Met  Leu Gly Val Gly Ala  Val Ala Ala His Asn  Ala Ile Glu 
    2570                 2575                 2580             


Ala Ser  Glu Gln Lys Arg Thr  Leu Leu Met Lys Val  Phe Val Lys 
    2585                 2590                 2595             


Asn Phe  Leu Asp Gln Ala Ala  Thr Asp Glu Leu Val  Lys Glu Ser 
    2600                 2605                 2610             


Pro Glu  Lys Ile Ile Met Ala  Leu Phe Glu Ala Val  Gln Thr Val 
    2615                 2620                 2625             


Gly Asn  Pro Leu Arg Leu Val  Tyr His Leu Tyr Gly  Val Phe Tyr 
    2630                 2635                 2640             


Lys Gly  Trp Glu Ala Lys Glu  Leu Ala Gln Arg Thr  Ala Gly Arg 
    2645                 2650                 2655             


Asn Leu  Phe Thr Leu Ile Met  Phe Glu Ala Val Glu  Leu Leu Gly 
    2660                 2665                 2670             


Val Asp  Ser Glu Gly Lys Ile  Arg Gln Leu Ser Ser  Asn Tyr Ile 
    2675                 2680                 2685             


Leu Glu  Leu Leu Tyr Lys Phe  Arg Asp Ser Ile Lys  Ser Ser Val 
    2690                 2695                 2700             


Arg Glu  Ile Ala Ile Ser Trp  Ala Pro Ala Pro Phe  Ser Cys Asp 
    2705                 2710                 2715             


Trp Thr  Pro Thr Asp Asp Arg  Ile Gly Leu Pro His  Asn Asn Tyr 
    2720                 2725                 2730             


Leu Gln  Met Glu Thr Arg Cys  Pro Cys Gly Tyr Arg  Met Lys Ala 
    2735                 2740                 2745             


Val Lys  Thr Cys Ala Gly Glu  Leu Arg Leu Leu Glu  Glu Gly Gly 
    2750                 2755                 2760             


Ser Phe  Leu Cys Arg Asn Lys  Phe Gly Arg Gly Ser  Arg Asn Tyr 
    2765                 2770                 2775             


Arg Val  Thr Lys Tyr Tyr Asp  Asp Asn Leu Ser Glu  Ile Lys Pro 
    2780                 2785                 2790             


Val Ile  Arg Met Glu Gly His  Val Glu Leu Tyr Tyr  Lys Gly Ala 
    2795                 2800                 2805             


Thr Ile  Lys Leu Asp Phe Asn  Asn Ser Lys Thr Val  Leu Ala Thr 
    2810                 2815                 2820             


Asp Lys  Trp Glu Val Asp His  Ser Thr Leu Val Arg  Ala Leu Lys 
    2825                 2830                 2835             


Arg His  Thr Gly Ala Gly Tyr  Gln Gly Ala Tyr Met  Gly Glu Lys 
    2840                 2845                 2850             


Pro Asn  His Lys His Leu Ile  Glu Arg Asp Cys Ala  Thr Ile Thr 
    2855                 2860                 2865             


Lys Asp  Lys Val Tyr Phe Ile  Lys Met Lys Arg Gly  Cys Ala Phe 
    2870                 2875                 2880             


Thr Tyr  Asp Leu Ser Leu His  Asn Leu Thr Arg Leu  Ile Glu Leu 
    2885                 2890                 2895             


Val His  Lys Asn Asp Leu Glu  Asp Arg Glu Ile Pro  Ala Val Thr 
    2900                 2905                 2910             


Val Thr  Thr Trp Leu Ala Tyr  Thr Phe Val Asn Glu  Asp Ile Gly 
    2915                 2920                 2925             


Thr Ile  Lys Pro Val Phe Gly  Glu Lys Val Thr Pro  Glu Lys Gln 
    2930                 2935                 2940             


Glu Glu  Val Ala Leu Gln Pro  Ala Val Val Val Asp  Thr Thr Asp 
    2945                 2950                 2955             


Val Ala  Val Thr Val Val Gly  Glu Thr Ser Thr Met  Thr Thr Gly 
    2960                 2965                 2970             


Glu Thr  Pro Thr Ala Phe Thr  Ser Leu Gly Ser Asp  Ser Lys Val 
    2975                 2980                 2985             


Gln Gln  Val Leu Lys Leu Gly  Val Asp Glu Gly Gln  Tyr Pro Gly 
    2990                 2995                 3000             


Pro Ser  Gln Gln Arg Ala Ser  Leu Leu Asp Ala Ile  Gln Gly Val 
    3005                 3010                 3015             


Asp Glu  Arg Pro Ser Val Leu  Ile Leu Gly Ser Asp  Lys Ala Thr 
    3020                 3025                 3030             


Ser Asn  Arg Val Lys Thr Ala  Lys Asn Val Lys Ile  Phe Arg Ser 
    3035                 3040                 3045             


Arg Asp  Pro Leu Glu Leu Arg  Glu Met Met Arg Arg  Gly Lys Ile 
    3050                 3055                 3060             


Leu Val  Ile Ala Leu Cys Lys  Val Asp Thr Ala Leu  Leu Lys Phe 
    3065                 3070                 3075             


Val Asp  Tyr Lys Gly Thr Phe  Leu Thr Arg Glu Thr  Leu Glu Ala 
    3080                 3085                 3090             


Leu Ser  Leu Gly Lys Pro Lys  Lys Lys Asn Ile Thr  Lys Thr Glu 
    3095                 3100                 3105             


Ala Gln  Trp Leu Leu Cys Leu  Glu Asn Gln Ile Glu  Glu Leu Pro 
    3110                 3115                 3120             


Asp Trp  Phe Ala Ala Glu Glu  Pro Val Phe Leu Glu  Ala Asn Ile 
    3125                 3130                 3135             


Lys Arg  Asp Lys Tyr His Leu  Val Gly Asp Ile Ala  Thr Ile Lys 
    3140                 3145                 3150             


Glu Lys  Ala Lys Gln Leu Gly  Ala Thr Asp Ser Thr  Lys Ile Ser 
    3155                 3160                 3165             


Lys Glu  Val Gly Ala Lys Val  Tyr Ser Met Lys Leu  Ser Asn Trp 
    3170                 3175                 3180             


Val Ile  Gln Glu Glu Asn Lys  Gln Gly Ser Leu Ala  Pro Leu Phe 
    3185                 3190                 3195             


Glu Glu  Leu Leu Gln Gln Cys  Pro Pro Gly Gly Gln  Asn Lys Thr 
    3200                 3205                 3210             


Thr His  Met Val Ser Ala Tyr  Gln Leu Ala Gln Gly  Asn Trp Met 
    3215                 3220                 3225             


Pro Val  Gly Cys His Val Phe  Met Gly Thr Ile Pro  Ala Arg Arg 
    3230                 3235                 3240             


Thr Lys  Thr His Pro Tyr Glu  Ala Tyr Val Lys Leu  Arg Glu Leu 
    3245                 3250                 3255             


Val Asp  Glu Tyr Lys Met Lys  Thr Leu Cys Gly Gly  Ser Gly Leu 
    3260                 3265                 3270             


Ser Lys  His Asn Glu Trp Val  Ile Arg Lys Ile Lys  His Gln Gly 
    3275                 3280                 3285             


Asn Leu  Arg Thr Lys His Met  Leu Asn Pro Gly Lys  Val Ala Glu 
    3290                 3295                 3300             


Gln Leu  Leu Arg Glu Gly His  Arg His Asn Val Tyr  Asn Lys Thr 
    3305                 3310                 3315             


Ile Gly  Ser Val Met Thr Ala  Thr Gly Ile Arg Leu  Glu Lys Leu 
    3320                 3325                 3330             


Pro Val  Val Arg Ala Gln Thr  Asp Thr Thr Asn Phe  His Gln Ala 
    3335                 3340                 3345             


Ile Arg  Asp Lys Ile Asp Lys  Glu Glu Asn Leu Gln  Thr Pro Gly 
    3350                 3355                 3360             


Leu His  Lys Lys Leu Met Glu  Val Phe Asn Ala Leu  Lys Arg Pro 
    3365                 3370                 3375             


Asp Leu  Glu Ala Ser Tyr Asp  Ala Val Glu Trp Glu  Glu Leu Glu 
    3380                 3385                 3390             


Lys Gly  Ile Asn Arg Lys Gly  Ala Ala Gly Phe Phe  Glu His Lys 
    3395                 3400                 3405             


Asn Ile  Gly Glu Val Leu Asp  Ser Glu Lys Asn Lys  Val Glu Glu 
    3410                 3415                 3420             


Ile Ile  Asp Ser Leu Arg Lys  Gly Arg Ser Ile Arg  Tyr Tyr Glu 
    3425                 3430                 3435             


Thr Ala  Ile Pro Lys Asn Glu  Lys Arg Asp Val Asn  Asp Asp Trp 
    3440                 3445                 3450             


Thr Ala  Gly Asp Phe Val Asp  Glu Lys Lys Pro Arg  Val Ile Gln 
    3455                 3460                 3465             


Tyr Pro  Glu Ala Lys Thr Arg  Leu Ala Ile Thr Lys  Val Met Tyr 
    3470                 3475                 3480             


Lys Trp  Val Lys Gln Lys Pro  Val Val Ile Pro Gly  Tyr Glu Gly 
    3485                 3490                 3495             


Lys Thr  Pro Leu Phe Gln Ile  Phe Asp Lys Val Lys  Lys Glu Trp 
    3500                 3505                 3510             


Asp Gln  Phe Gln Asn Pro Val  Ala Val Ser Phe Asp  Thr Lys Ala 
    3515                 3520                 3525             


Trp Asp  Thr Gln Val Thr Thr  Gly Asp Leu Glu Leu  Ile Arg Asp 
    3530                 3535                 3540             


Ile Gln  Lys Phe Tyr Phe Lys  Lys Lys Trp His Lys  Phe Ile Asp 
    3545                 3550                 3555             


Thr Leu  Thr Met His Met Ser  Glu Val Pro Val Ile  Ser Ala Asp 
    3560                 3565                 3570             


Gly Glu  Val Tyr Ile Arg Lys  Gly Gln Arg Gly Ser  Gly Gln Pro 
    3575                 3580                 3585             


Asp Thr  Ser Ala Gly Asn Ser  Met Leu Asn Val Leu  Thr Met Val 
    3590                 3595                 3600             


Tyr Ala  Phe Cys Glu Ala Thr  Gly Val Pro Tyr Lys  Ser Phe Asp 
    3605                 3610                 3615             


Arg Val  Ala Lys Ile His Val  Cys Gly Asp Asp Gly  Phe Leu Ile 
    3620                 3625                 3630             


Thr Glu  Arg Ala Leu Gly Glu  Lys Phe Ser Ser Lys  Gly Val Gln 
    3635                 3640                 3645             


Ile Leu  Tyr Glu Ala Gly Lys  Pro Gln Lys Ile Thr  Glu Gly Asp 
    3650                 3655                 3660             


Lys Met  Lys Val Ala Tyr Gln  Phe Asp Asp Ile Glu  Phe Cys Ser 
    3665                 3670                 3675             


His Thr  Pro Val Gln Val Arg  Trp Ser Asp Asn Thr  Ser Ser Tyr 
    3680                 3685                 3690             


Met Pro  Gly Arg Asn Thr Thr  Thr Ile Leu Ala Lys  Met Ala Thr 
    3695                 3700                 3705             


Arg Leu  Asp Ser Ser Gly Glu  Arg Gly Thr Ile Ala  Tyr Glu Lys 
    3710                 3715                 3720             


Ala Val  Ala Phe Ser Phe Leu  Leu Met Tyr Ser Trp  Asn Pro Leu 
    3725                 3730                 3735             


Ile Arg  Arg Ile Cys Leu Leu  Val Leu Ser Thr Glu  Leu Gln Val 
    3740                 3745                 3750             


Arg Pro  Gly Lys Ser Thr Thr  Tyr Tyr Tyr Glu Gly  Asp Pro Ile 
    3755                 3760                 3765             


Ser Ala  Tyr Lys Glu Val Ile  Gly His Asn Leu Phe  Asp Leu Lys 
    3770                 3775                 3780             


Arg Thr  Ser Phe Glu Lys Leu  Ala Lys Leu Asn Leu  Ser Met Ser 
    3785                 3790                 3795             


Thr Leu  Gly Val Trp Thr Arg  His Thr Ser Lys Arg  Leu Leu Gln 
    3800                 3805                 3810             


Asp Cys  Val Asn Val Gly Thr  Lys Glu Gly Asn Trp  Leu Val Asn 
    3815                 3820                 3825             


Ala Asp  Arg Leu Val Ser Ser  Lys Thr Gly Asn Arg  Tyr Ile Pro 
    3830                 3835                 3840             


Gly Glu  Gly His Thr Gln Gln  Gly Lys His Tyr Glu  Glu Leu Ile 
    3845                 3850                 3855             


Leu Ala  Arg Lys Pro Ile Ser  Asn Phe Glu Gly Thr  Asp Arg Tyr 
    3860                 3865                 3870             


Asn Leu  Gly Pro Ile Val Asn  Val Val Leu Arg Arg  Leu Arg Val 
    3875                 3880                 3885             


Met Met  Met Ala Leu Ile Gly  Arg Gly Val 
    3890                 3895             


<210>  14
<211>  3898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyprotein of GD18

<400>  14

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Asn Lys Gln Lys 
1               5                   10                  15      


Pro Ile Gly Val Glu Glu Pro Val Tyr Asp Ile Ala Gly Arg Pro Phe 
            20                  25                  30          


Phe Gly Asp Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asn Ile Arg Thr Thr Leu Lys Asn Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Val Lys Pro Gly Pro Val Phe Tyr Gln Asp Tyr Met Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Glu Glu Ala Gln Leu Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Ile Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Thr Pro Arg Ser Leu Lys Trp Thr Arg Asn Phe Thr Asp 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Ser Asp Asp Gly Ala Gly Gly Ser 
                165                 170                 175     


Lys Asp Lys Lys Pro Asp Arg Met Asn Lys Gly Lys Leu Lys Ile Ala 
            180                 185                 190         


Pro Lys Glu His Glu Lys Asp Ser Lys Thr Lys Pro Pro Asp Ala Thr 
        195                 200                 205             


Ile Val Val Glu Gly Val Lys Tyr Gln Val Lys Lys Lys Gly Lys Val 
    210                 215                 220                 


Lys Gly Lys Asn Thr Gln Asp Gly Leu Tyr His Asn Lys Asn Lys Pro 
225                 230                 235                 240 


Pro Glu Ser Arg Lys Lys Leu Glu Lys Ala Leu Leu Ala Trp Ala Val 
                245                 250                 255     


Ile Thr Ile Val Leu Tyr Gln Pro Val Ala Ala Glu Asn Ile Thr Gln 
            260                 265                 270         


Trp Asn Leu Ser Asp Asn Gly Thr Ser Gly Ile Gln Gln Ala Met Tyr 
        275                 280                 285             


Leu Arg Gly Val Asn Arg Ser Leu His Gly Ile Trp Pro Glu Lys Ile 
    290                 295                 300                 


Cys Lys Gly Val Pro Thr His Leu Ala Thr Asp Thr Glu Leu Thr Glu 
305                 310                 315                 320 


Ile Arg Gly Met Met Asp Ala Ser Glu Arg Thr Asn Tyr Thr Cys Cys 
                325                 330                 335     


Arg Leu Gln Arg His Glu Trp Asn Lys His Gly Trp Cys Asn Trp Tyr 
            340                 345                 350         


Asn Ile Asp Pro Trp Ile Gln Leu Met Asn Arg Thr Gln Ala Asn Leu 
        355                 360                 365             


Thr Glu Gly Pro Pro Asp Lys Glu Cys Ala Val Thr Cys Arg Tyr Asp 
    370                 375                 380                 


Lys Asn Ala Asp Val Asn Val Val Thr Gln Ala Arg Asn Arg Pro Thr 
385                 390                 395                 400 


Thr Leu Thr Gly Cys Lys Lys Gly Lys Asn Phe Ser Phe Ala Gly Thr 
                405                 410                 415     


Ile Ile Glu Gly Pro Cys Asn Phe Asn Val Ser Val Glu Asp Ile Leu 
            420                 425                 430         


Tyr Gly Asp His Glu Cys Gly Ser Leu Phe Gln Asp Thr Ala Leu Tyr 
        435                 440                 445             


Leu Leu Asp Gly Met Thr Asn Thr Ile Glu Lys Ala Arg Gln Gly Ala 
    450                 455                 460                 


Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Ser Thr Thr Gly Lys 
465                 470                 475                 480 


Lys Leu Glu Arg Gly Ser Lys Thr Trp Phe Gly Ala Tyr Ala Leu Ser 
                485                 490                 495     


Pro Tyr Cys Asn Val Thr Arg Lys Val Gly Tyr Ile Trp Tyr Thr Asn 
            500                 505                 510         


Asn Cys Thr Pro Ala Cys Leu Pro Lys Asn Thr Lys Ile Ile Gly Pro 
        515                 520                 525             


Gly Lys Phe Asp Thr Asn Ala Glu Asp Gly Lys Ile Leu His Glu Met 
    530                 535                 540                 


Gly Gly His Leu Ser Glu Phe Leu Leu Leu Ser Leu Val Ile Leu Ser 
545                 550                 555                 560 


Asp Phe Ala Pro Glu Thr Ala Ser Thr Leu Tyr Leu Ile Leu His Tyr 
                565                 570                 575     


Ala Ile Pro Gln Ser His Glu Glu Pro Glu Gly Cys Asp Thr Asn Gln 
            580                 585                 590         


Leu Asn Leu Thr Val Gly Leu Arg Thr Glu Asp Val Val Pro Ser Ser 
        595                 600                 605             


Val Trp Asn Ile Gly Lys Tyr Val Cys Val Arg Pro Asp Trp Trp Pro 
    610                 615                 620                 


Tyr Glu Thr Lys Val Ala Leu Leu Phe Glu Glu Ala Gly Gln Val Ile 
625                 630                 635                 640 


Lys Leu Ala Leu Arg Ala Leu Arg Asp Leu Thr Arg Val Trp Asn Ser 
                645                 650                 655     


Ala Ser Thr Thr Ala Phe Leu Ile Cys Leu Ile Lys Ile Leu Arg Gly 
            660                 665                 670         


Gln Val Val Gln Gly Ile Ile Trp Leu Leu Leu Val Thr Gly Ala Gln 
        675                 680                 685             


Gly Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr 
    690                 695                 700                 


Asn Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys 
705                 710                 715                 720 


Glu Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr 
                725                 730                 735     


Cys Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg 
            740                 745                 750         


Arg Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr 
        755                 760                 765             


Phe Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly 
    770                 775                 780                 


Asp Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val 
785                 790                 795                 800 


Lys Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu 
                805                 810                 815     


Val Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser 
            820                 825                 830         


Pro Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys 
        835                 840                 845             


Pro Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu 
    850                 855                 860                 


Asp Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly 
865                 870                 875                 880 


Asp Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys 
                885                 890                 895     


Gly Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly 
            900                 905                 910         


Lys Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr 
        915                 920                 925             


Asp Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu 
    930                 935                 940                 


Cys Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg 
945                 950                 955                 960 


Leu Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly 
                965                 970                 975     


Pro Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg 
            980                 985                 990         


Asn Lys Tyr Tyr Glu Pro Arg Asp  Ser Tyr Phe Gln Gln  Tyr Met Leu 
        995                 1000                 1005             


Lys Gly  Glu Tyr Gln Tyr Trp  Phe Asp Leu Asp Val  Thr Asp His 
    1010                 1015                 1020             


His Thr  Asp Tyr Phe Ala Glu  Phe Val Val Leu Val  Val Val Ala 
    1025                 1030                 1035             


Leu Leu  Gly Gly Arg Tyr Val  Leu Trp Leu Ile Val  Thr Tyr Ile 
    1040                 1045                 1050             


Val Leu  Thr Glu Gln Leu Ala  Ala Gly Leu Gln Leu  Gly Gln Gly 
    1055                 1060                 1065             


Glu Val  Val Leu Ile Gly Asn  Leu Ile Thr His Met  Asp Asn Glu 
    1070                 1075                 1080             


Val Val  Val Tyr Phe Leu Leu  Leu Tyr Leu Ile Ile  Arg Asp Glu 
    1085                 1090                 1095             


Pro Ile  Lys Lys Trp Ile Leu  Leu Leu Phe His Ala  Met Thr Asn 
    1100                 1105                 1110             


Asn Pro  Val Lys Thr Met Thr  Val Ala Leu Leu Met  Ile Ser Gly 
    1115                 1120                 1125             


Val Ala  Lys Gly Gly Lys Ile  Asp Gly Gly Trp Gln  Arg Gln Pro 
    1130                 1135                 1140             


Glu Thr  Asn Phe Asp Ile Gln  Phe Ala Leu Ala Val  Ile Ile Val 
    1145                 1150                 1155             


Val Val  Met Leu Leu Ala Lys  Arg Asp Pro Thr Thr  Phe Pro Leu 
    1160                 1165                 1170             


Val Ile  Thr Val Ala Thr Leu  Arg Thr Ala Lys Ile  Thr Ser Gly 
    1175                 1180                 1185             


Phe Ser  Thr Asp Leu Ala Ile  Ala Thr Val Ser Ala  Thr Leu Leu 
    1190                 1195                 1200             


Thr Trp  Thr Tyr Ile Ser Asp  Tyr Tyr Lys Tyr Lys  Thr Trp Leu 
    1205                 1210                 1215             


Gln Tyr  Leu Ile Ser Thr Val  Thr Gly Ile Phe Leu  Ile Arg Val 
    1220                 1225                 1230             


Leu Lys  Gly Val Gly Glu Leu  Asp Leu His Ala Pro  Thr Leu Pro 
    1235                 1240                 1245             


Ser His  Arg Pro Leu Phe Tyr  Ile Leu Val Tyr Leu  Ile Ser Thr 
    1250                 1255                 1260             


Ala Val  Val Thr Arg Trp Asn  Leu Asp Val Ala Gly  Ile Leu Leu 
    1265                 1270                 1275             


Gln Cys  Ala Pro Thr Leu Leu  Met Val Phe Thr Met  Trp Ala Asp 
    1280                 1285                 1290             


Ile Leu  Thr Leu Ile Leu Ile  Leu Pro Thr Tyr Glu  Leu Thr Lys 
    1295                 1300                 1305             


Leu Tyr  Tyr Leu Lys Glu Val  Lys Ile Gly Thr Glu  Arg Gly Trp 
    1310                 1315                 1320             


Leu Trp  Lys Thr Asn Tyr Lys  Arg Val Asn Asp Ile  Tyr Glu Val 
    1325                 1330                 1335             


Asp Gln  Ala Gly Glu Gly Val  Tyr Leu Phe Pro Ser  Lys Gln Lys 
    1340                 1345                 1350             


Thr Gly  Ala Ile Thr Ser Thr  Val Leu Pro Leu Ile  Lys Ala Ile 
    1355                 1360                 1365             


Leu Ile  Ser Cys Ile Ser Asn  Lys Trp Gln Phe Ile  Tyr Leu Leu 
    1370                 1375                 1380             


Tyr Leu  Ile Phe Glu Val Ser  Tyr Tyr Leu His Lys  Lys Ile Ile 
    1385                 1390                 1395             


Asp Glu  Ile Ala Gly Gly Thr  Asn Phe Val Ser Arg  Leu Val Ala 
    1400                 1405                 1410             


Ala Leu  Ile Glu Val Asn Trp  Ala Leu Asp Asn Glu  Glu Val Lys 
    1415                 1420                 1425             


Gly Leu  Lys Lys Phe Phe Leu  Leu Ser Ser Arg Val  Lys Glu Leu 
    1430                 1435                 1440             


Val Ile  Lys His Lys Val Arg  Asn Glu Val Met Val  Arg Trp Phe 
    1445                 1450                 1455             


Glu Asp  Glu Glu Ile Tyr Gly  Met Pro Lys Leu Ile  Gly Leu Val 
    1460                 1465                 1470             


Lys Ala  Ala Thr Leu Ser Lys  Asn Lys His Cys Ile  Leu Cys Thr 
    1475                 1480                 1485             


Val Cys  Glu Asp Arg Asp Trp  Arg Gly Glu Thr Cys  Pro Lys Cys 
    1490                 1495                 1500             


Gly Arg  Phe Gly Pro Pro Val  Ile Cys Gly Met Thr  Leu Ala Asp 
    1505                 1510                 1515             


Phe Glu  Glu Lys His Tyr Lys  Arg Ile Phe Ile Arg  Glu Asp Gln 
    1520                 1525                 1530             


Ser Asp  Gly Pro Leu Arg Glu  Glu His Ala Gly Tyr  Leu Gln Tyr 
    1535                 1540                 1545             


Lys Ala  Arg Gly Gln Leu Phe  Leu Arg Asn Leu Pro  Val Leu Ala 
    1550                 1555                 1560             


Thr Lys  Val Lys Met Leu Leu  Val Gly Asn Leu Gly  Thr Glu Val 
    1565                 1570                 1575             


Gly Asp  Leu Glu His Leu Gly  Trp Val Leu Arg Gly  Pro Ala Val 
    1580                 1585                 1590             


Cys Lys  Lys Val Thr Glu His  Glu Lys Cys Ala Thr  Ser Ile Met 
    1595                 1600                 1605             


Asp Lys  Leu Thr Ala Phe Phe  Gly Val Met Pro Arg  Gly Thr Thr 
    1610                 1615                 1620             


Pro Arg  Ala Pro Val Arg Phe  Pro Thr Ser Leu Leu  Lys Ile Arg 
    1625                 1630                 1635             


Arg Gly  Leu Glu Thr Gly Trp  Ala Tyr Thr His Gln  Gly Gly Ile 
    1640                 1645                 1650             


Ser Ser  Val Asp His Val Thr  Cys Gly Lys Asp Leu  Leu Val Cys 
    1655                 1660                 1665             


Asp Thr  Met Gly Arg Thr Arg  Val Val Cys Gln Ser  Asn Asn Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Ser Glu Tyr  Gly Val Lys Thr Asp  Ser Gly Cys 
    1685                 1690                 1695             


Pro Glu  Gly Ala Arg Cys Tyr  Val Phe Asn Pro Glu  Ala Val Asn 
    1700                 1705                 1710             


Ile Ser  Gly Thr Lys Gly Ala  Met Val His Leu Gln  Lys Thr Gly 
    1715                 1720                 1725             


Gly Glu  Phe Thr Cys Val Thr  Ala Ser Gly Thr Pro  Ala Phe Phe 
    1730                 1735                 1740             


Asp Leu  Lys Asn Leu Lys Gly  Trp Ser Gly Leu Pro  Ile Phe Glu 
    1745                 1750                 1755             


Ala Ser  Ser Gly Arg Val Val  Gly Arg Val Lys Val  Gly Lys Asn 
    1760                 1765                 1770             


Glu Asp  Ser Lys Pro Thr Lys  Leu Met Ser Gly Ile  Gln Thr Val 
    1775                 1780                 1785             


Ser Lys  Ser Ala Thr Asp Leu  Thr Glu Met Val Lys  Lys Ile Thr 
    1790                 1795                 1800             


Thr Met  Asn Arg Gly Glu Phe  Arg Gln Ile Thr Leu  Ala Thr Gly 
    1805                 1810                 1815             


Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Ser Val Ile  Glu Glu Ile 
    1820                 1825                 1830             


Gly Arg  His Lys Arg Val Leu  Val Leu Ile Pro Leu  Arg Ala Ala 
    1835                 1840                 1845             


Ala Glu  Ser Val Tyr Gln Tyr  Met Arg Gln Lys His  Pro Ser Ile 
    1850                 1855                 1860             


Ala Phe  Asn Leu Arg Ile Gly  Glu Met Glu Glu Gly  Tyr Met Ala 
    1865                 1870                 1875             


Thr Gly  Ile Thr Tyr Ala Ser  Tyr Gly Tyr Phe Cys  Gln Met Pro 
    1880                 1885                 1890             


Gln Pro  Lys Leu Arg Ala Ala  Met Val Glu Tyr Ser  Tyr Ile Phe 
    1895                 1900                 1905             


Leu Asp  Glu Tyr His Cys Ala  Thr Pro Glu Gln Leu  Ala Ile Met 
    1910                 1915                 1920             


Gly Lys  Ile His Arg Phe Ser  Glu Asn Leu Arg Val  Val Ala Met 
    1925                 1930                 1935             


Thr Ala  Thr Pro Ala Gly Thr  Val Thr Thr Thr Gly  Gln Lys His 
    1940                 1945                 1950             


Pro Ile  Glu Glu Phe Ile Ala  Pro Glu Val Met Lys  Gly Glu Asp 
    1955                 1960                 1965             


Leu Gly  Ser Glu Tyr Leu Asp  Ile Ala Gly Leu Lys  Ile Pro Val 
    1970                 1975                 1980             


Glu Glu  Met Lys Asn Asn Met  Leu Val Phe Val Pro  Thr Arg Asn 
    1985                 1990                 1995             


Met Ala  Val Glu Ala Ala Lys  Lys Leu Lys Ala Lys  Gly Tyr Asn 
    2000                 2005                 2010             


Ser Gly  Tyr Tyr Tyr Ser Gly  Glu Asp Pro Ser Asn  Leu Arg Val 
    2015                 2020                 2025             


Val Thr  Ser Gln Ser Pro Tyr  Val Val Val Ala Thr  Asn Ala Ile 
    2030                 2035                 2040             


Glu Ser  Gly Val Thr Leu Pro  Asp Leu Asp Val Val  Val Asp Thr 
    2045                 2050                 2055             


Gly Leu  Lys Cys Glu Lys Arg  Ile Arg Leu Ser Pro  Lys Met Pro 
    2060                 2065                 2070             


Phe Ile  Val Thr Gly Leu Lys  Arg Met Ala Val Thr  Ile Gly Glu 
    2075                 2080                 2085             


Gln Ala  Gln Arg Arg Gly Arg  Val Gly Arg Val Lys  Pro Gly Arg 
    2090                 2095                 2100             


Tyr Tyr  Arg Ser Gln Glu Thr  Pro Val Gly Ser Lys  Asp Tyr His 
    2105                 2110                 2115             


Tyr Asp  Leu Leu Gln Ala Gln  Arg Tyr Gly Ile Glu  Asp Gly Ile 
    2120                 2125                 2130             


Asn Ile  Thr Lys Ser Phe Arg  Glu Met Asn Tyr Asp  Trp Ser Leu 
    2135                 2140                 2145             


Tyr Glu  Glu Asp Ser Leu Met  Ile Thr Gln Leu Glu  Ile Leu Asn 
    2150                 2155                 2160             


Asn Leu  Leu Ile Ser Glu Glu  Leu Pro Val Ala Val  Lys Asn Ile 
    2165                 2170                 2175             


Met Ala  Arg Thr Asp His Pro  Glu Pro Ile Gln Leu  Ala Tyr Asn 
    2180                 2185                 2190             


Ser Tyr  Glu Thr Gln Val Pro  Val Leu Phe Pro Lys  Ile Arg Asn 
    2195                 2200                 2205             


Gly Glu  Val Thr Asp Thr Tyr  Asp Asn Tyr Thr Phe  Leu Asn Ala 
    2210                 2215                 2220             


Arg Lys  Leu Gly Asp Asp Val  Pro Pro Tyr Val Tyr  Ala Thr Glu 
    2225                 2230                 2235             


Asp Glu  Asp Leu Ala Val Glu  Leu Leu Gly Leu Asp  Trp Pro Asp 
    2240                 2245                 2250             


Pro Gly  Asn Gln Gly Thr Val  Glu Ala Gly Arg Ala  Leu Lys Gln 
    2255                 2260                 2265             


Val Val  Gly Leu Ser Thr Ala  Glu Asn Ala Leu Leu  Val Ala Leu 
    2270                 2275                 2280             


Phe Gly  Tyr Val Gly Tyr Gln  Ala Leu Ser Lys Arg  His Ile Pro 
    2285                 2290                 2295             


Val Val  Thr Asp Ile Tyr Ser  Val Glu Asp His Arg  Leu Glu Asp 
    2300                 2305                 2310             


Thr Thr  His Leu Gln Tyr Ala  Pro Asn Ala Ile Lys  Thr Glu Gly 
    2315                 2320                 2325             


Lys Glu  Thr Glu Leu Lys Glu  Leu Ala Gln Gly Asp  Val Gln Arg 
    2330                 2335                 2340             


Cys Val  Glu Ala Val Ala Asn  Tyr Ala Ser Glu Gly  Ile Gln Phe 
    2345                 2350                 2355             


Ile Lys  Ser Gln Ala Leu Lys  Val Arg Glu Thr Pro  Thr Tyr Lys 
    2360                 2365                 2370             


Glu Thr  Met Asn Thr Val Ala  Asp Tyr Val Lys Lys  Phe Ile Glu 
    2375                 2380                 2385             


Ala Leu  Ser Asp Ser Lys Glu  Asp Ile Leu Lys Tyr  Gly Leu Trp 
    2390                 2395                 2400             


Gly Val  His Thr Ala Leu Tyr  Lys Ser Ile Gly Ala  Arg Leu Gly 
    2405                 2410                 2415             


His Glu  Thr Ala Phe Ala Thr  Leu Val Val Lys Trp  Leu Ala Phe 
    2420                 2425                 2430             


Gly Gly  Glu Ser Val Thr Asp  His Ile Lys Gln Ala  Ala Thr Asp 
    2435                 2440                 2445             


Leu Val  Val Tyr Tyr Ile Ile  Asn Arg Pro Gln Phe  Pro Gly Asp 
    2450                 2455                 2460             


Thr Glu  Thr Gln Gln Glu Gly  Arg Lys Phe Val Ala  Ser Leu Leu 
    2465                 2470                 2475             


Val Ser  Ala Leu Ala Thr Tyr  Thr Tyr Lys Ser Trp  Asn Tyr Asn 
    2480                 2485                 2490             


Asn Leu  Ser Lys Ile Val Glu  Pro Ala Leu Ala Thr  Leu Pro Tyr 
    2495                 2500                 2505             


Ala Ala  Lys Ala Leu Lys Leu  Phe Ala Pro Thr Arg  Leu Glu Ser 
    2510                 2515                 2520             


Val Val  Ile Leu Ser Thr Ala  Ile Tyr Lys Thr Tyr  Leu Ser Ile 
    2525                 2530                 2535             


Arg Arg  Gly Lys Ser Asp Gly  Leu Leu Gly Thr Gly  Val Ser Ala 
    2540                 2545                 2550             


Ala Met  Glu Ile Met Ser Gln  Asn Pro Val Ser Val  Gly Ile Ala 
    2555                 2560                 2565             


Val Met  Leu Gly Val Gly Ala  Val Ala Ala His Asn  Ala Ile Glu 
    2570                 2575                 2580             


Ala Ser  Glu Gln Lys Arg Thr  Leu Leu Met Lys Val  Phe Val Lys 
    2585                 2590                 2595             


Asn Phe  Leu Asp Gln Ala Ala  Thr Asp Glu Leu Val  Lys Glu Ser 
    2600                 2605                 2610             


Pro Glu  Lys Ile Ile Met Ala  Leu Phe Glu Ala Val  Gln Thr Val 
    2615                 2620                 2625             


Gly Asn  Pro Leu Arg Leu Val  Tyr His Leu Tyr Gly  Val Phe Tyr 
    2630                 2635                 2640             


Lys Gly  Trp Glu Ala Lys Glu  Leu Ala Gln Arg Thr  Ala Gly Arg 
    2645                 2650                 2655             


Asn Leu  Phe Thr Leu Ile Met  Phe Glu Ala Val Glu  Leu Leu Gly 
    2660                 2665                 2670             


Val Asp  Ser Glu Gly Lys Ile  Arg Gln Leu Ser Ser  Asn Tyr Ile 
    2675                 2680                 2685             


Leu Glu  Leu Leu Tyr Lys Phe  Arg Asp Asp Ile Lys  Ser Ser Val 
    2690                 2695                 2700             


Arg Glu  Ile Ala Ile Ser Trp  Ala Pro Ala Pro Phe  Ser Cys Asp 
    2705                 2710                 2715             


Trp Thr  Pro Thr Asp Asp Arg  Ile Gly Leu Pro His  Asp Asn Tyr 
    2720                 2725                 2730             


Leu Gln  Met Glu Thr Arg Cys  Pro Cys Gly Tyr Arg  Met Lys Ala 
    2735                 2740                 2745             


Val Lys  Thr Cys Ala Gly Glu  Leu Arg Leu Leu Glu  Glu Gly Gly 
    2750                 2755                 2760             


Ser Phe  Leu Cys Arg Asn Lys  Phe Gly Arg Gly Ser  Arg Asn Tyr 
    2765                 2770                 2775             


Arg Val  Thr Lys Tyr Tyr Asp  Asp Asn Leu Ser Glu  Ile Lys Pro 
    2780                 2785                 2790             


Val Ile  Arg Met Glu Gly His  Val Glu Leu Tyr His  Lys Gly Ala 
    2795                 2800                 2805             


Thr Phe  Lys Leu Asp Phe Asp  Asn Ser Lys Thr Val  Leu Ala Thr 
    2810                 2815                 2820             


Asp Arg  Trp Glu Val Asp His  Ser Thr Leu Ile Arg  Val Leu Lys 
    2825                 2830                 2835             


Arg His  Thr Gly Ala Gly Phe  Gln Gly Ala Tyr Leu  Gly Glu Lys 
    2840                 2845                 2850             


Pro Asn  His Lys His Leu Ile  Glu Arg Asp Cys Ala  Thr Ile Thr 
    2855                 2860                 2865             


Lys Asp  Lys Val Cys Phe Ile  Lys Met Lys Arg Gly  Cys Ala Phe 
    2870                 2875                 2880             


Thr Tyr  Asp Leu Ser Leu His  Asn Leu Thr Arg Leu  Ile Glu Leu 
    2885                 2890                 2895             


Val His  Lys Asn Asn Leu Asp  Asp Arg Glu Ile Pro  Ala Val Thr 
    2900                 2905                 2910             


Val Thr  Thr Trp Leu Ala Tyr  Thr Phe Val Asn Glu  Asp Ile Gly 
    2915                 2920                 2925             


Thr Ile  Lys Pro Val Phe Gly  Glu Lys Val Thr Pro  Glu Lys Gln 
    2930                 2935                 2940             


Glu Glu  Val Ala Leu Gln Pro  Ala Val Val Val Asp  Thr Thr Asp 
    2945                 2950                 2955             


Val Ala  Val Thr Val Val Gly  Glu Thr Ser Thr Met  Thr Thr Gly 
    2960                 2965                 2970             


Glu Thr  Pro Thr Ile Phe Thr  Ser Leu Gly Ser Asp  Ser Lys Phe 
    2975                 2980                 2985             


Gln Gln  Val Leu Lys Leu Gly  Val Asp Glu Gly Gln  Tyr Pro Gly 
    2990                 2995                 3000             


Pro Arg  Gln Gln Arg Ala Ser  Leu Leu Glu Ala Val  Gln Gly Val 
    3005                 3010                 3015             


Asp Glu  Arg Pro Ser Val Leu  Ile Leu Gly Ser Asp  Lys Ala Thr 
    3020                 3025                 3030             


Ser Asn  Arg Val Lys Thr Ala  Lys Asn Val Lys Ile  Phe Arg Ser 
    3035                 3040                 3045             


Arg Asp  Pro Leu Glu Leu Arg  Glu Met Met Arg Arg  Gly Lys Ile 
    3050                 3055                 3060             


Leu Ile  Ile Ala Leu Cys Lys  Val Asp Thr Ala Leu  Leu Lys Phe 
    3065                 3070                 3075             


Val Asp  Tyr Lys Gly Thr Phe  Leu Thr Arg Glu Thr  Leu Glu Ala 
    3080                 3085                 3090             


Leu Ser  Leu Gly Lys Pro Lys  Lys Arg Asp Ile Thr  Lys Thr Glu 
    3095                 3100                 3105             


Ala Arg  Trp Leu Leu Cys Leu  Glu Gly Gln Leu Glu  Glu Leu Pro 
    3110                 3115                 3120             


Asp Trp  Phe Ala Ala Lys Glu  Pro Ile Phe Leu Glu  Ala Asn Ile 
    3125                 3130                 3135             


Lys Arg  Asp Lys Tyr His Leu  Val Gly Asp Ile Ala  Thr Ile Lys 
    3140                 3145                 3150             


Glu Lys  Ala Lys Gln Leu Gly  Ala Thr Asp Ser Thr  Lys Ile Ser 
    3155                 3160                 3165             


Lys Glu  Val Gly Ala Lys Val  Tyr Ser Met Lys Leu  Ser Asn Trp 
    3170                 3175                 3180             


Val Ile  Gln Glu Glu Asn Lys  Gln Gly Ser Leu Thr  Pro Leu Phe 
    3185                 3190                 3195             


Glu Glu  Leu Leu Gln Gln Cys  Pro Pro Gly Gly Gln  Asn Lys Thr 
    3200                 3205                 3210             


Thr His  Met Ala Ser Ala Tyr  Gln Leu Ala Gln Gly  Asn Trp Met 
    3215                 3220                 3225             


Pro Val  Gly Cys His Val Phe  Met Gly Thr Ile Pro  Ala Arg Arg 
    3230                 3235                 3240             


Thr Lys  Thr His Pro Tyr Glu  Ala Tyr Val Lys Leu  Arg Glu Leu 
    3245                 3250                 3255             


Val Glu  Glu His Lys Met Lys  Thr Ser Cys Gly Gly  Ser Gly Leu 
    3260                 3265                 3270             


Cys Lys  His Asn Glu Trp Val  Ile Arg Lys Ile Lys  His Gln Gly 
    3275                 3280                 3285             


Asn Leu  Arg Thr Arg His Met  Leu Asn Pro Gly Lys  Ile Ala Glu 
    3290                 3295                 3300             


Gln Leu  Asp Arg Glu Gly His  Arg His Asn Val Tyr  Asn Lys Thr 
    3305                 3310                 3315             


Ile Gly  Ser Val Met Thr Ala  Thr Gly Ile Arg Leu  Glu Lys Leu 
    3320                 3325                 3330             


Pro Val  Val Arg Ala Gln Thr  Asp Thr Thr Asn Phe  His Gln Ala 
    3335                 3340                 3345             


Ile Arg  Asp Lys Ile Asp Lys  Glu Glu Asn Leu Gln  Thr Pro Gly 
    3350                 3355                 3360             


Leu His  Lys Lys Leu Met Glu  Val Phe Asn Ala Leu  Lys Arg Pro 
    3365                 3370                 3375             


Glu Leu  Glu Ala Ser Tyr Asp  Ala Val Glu Trp Glu  Glu Leu Glu 
    3380                 3385                 3390             


Arg Gly  Ile Asn Arg Lys Gly  Ala Ala Gly Phe Phe  Glu Arg Lys 
    3395                 3400                 3405             


Asn Ile  Gly Glu Val Leu Asp  Ser Glu Lys Tyr Lys  Val Glu Glu 
    3410                 3415                 3420             


Ile Ile  Asp Ser Leu Lys Lys  Gly Arg Ser Ile Lys  Tyr Tyr Glu 
    3425                 3430                 3435             


Thr Ala  Ile Pro Lys Asn Glu  Lys Arg Asp Val Asn  Asp Asp Trp 
    3440                 3445                 3450             


Thr Ala  Gly Asp Phe Val Asp  Glu Lys Lys Pro Arg  Val Ile Gln 
    3455                 3460                 3465             


Tyr Pro  Glu Ala Lys Thr Arg  Leu Ala Ile Thr Lys  Val Met Tyr 
    3470                 3475                 3480             


Lys Trp  Val Lys Gln Lys Pro  Val Val Ile Pro Gly  Tyr Glu Gly 
    3485                 3490                 3495             


Lys Thr  Pro Leu Phe Gln Ile  Phe Asp Lys Val Lys  Lys Glu Trp 
    3500                 3505                 3510             


Asn Gln  Phe Gln Asn Pro Val  Ala Val Ser Phe Asp  Thr Lys Ala 
    3515                 3520                 3525             


Trp Asp  Thr Gln Val Thr Thr  Arg Asp Leu Glu Leu  Ile Arg Asp 
    3530                 3535                 3540             


Ile Gln  Lys Phe Tyr Phe Lys  Lys Lys Trp His Lys  Phe Ile Asp 
    3545                 3550                 3555             


Thr Leu  Thr Met His Met Ser  Glu Val Pro Val Ile  Ser Ala Asp 
    3560                 3565                 3570             


Gly Glu  Val Tyr Ile Arg Lys  Gly Gln Arg Gly Ser  Gly Gln Pro 
    3575                 3580                 3585             


Asp Thr  Ser Ala Gly Asn Ser  Met Leu Asn Val Leu  Thr Met Val 
    3590                 3595                 3600             


Tyr Ala  Phe Cys Glu Ala Thr  Gly Val Pro Tyr Lys  Ser Phe Asp 
    3605                 3610                 3615             


Arg Val  Ala Lys Ile His Val  Cys Gly Asp Asp Gly  Phe Leu Ile 
    3620                 3625                 3630             


Thr Glu  Arg Ala Leu Gly Glu  Lys Phe Ala Ser Arg  Gly Val Gln 
    3635                 3640                 3645             


Ile Leu  Tyr Glu Ala Gly Lys  Pro Gln Lys Ile Thr  Glu Gly Asp 
    3650                 3655                 3660             


Asn Met  Lys Val Ala Tyr Gln  Phe Asp Asp Ile Glu  Phe Cys Ser 
    3665                 3670                 3675             


His Thr  Pro Val Gln Val Arg  Trp Ser Asp Asn Thr  Ser Ser Tyr 
    3680                 3685                 3690             


Met Pro  Gly Arg Asn Thr Thr  Thr Ile Leu Ala Lys  Met Ala Thr 
    3695                 3700                 3705             


Arg Leu  Asp Ser Ser Gly Glu  Arg Gly Thr Ile Ala  Tyr Glu Lys 
    3710                 3715                 3720             


Ala Val  Ala Phe Ser Phe Leu  Leu Met Tyr Ser Trp  Asn Pro Leu 
    3725                 3730                 3735             


Ile Arg  Arg Ile Cys Leu Leu  Val Leu Ser Thr Glu  Met Gln Val 
    3740                 3745                 3750             


Arg Pro  Gly Lys Ser Thr Thr  Tyr Tyr Tyr Glu Gly  Asp Pro Ile 
    3755                 3760                 3765             


Ser Ala  Tyr Lys Glu Val Ile  Gly His Asn Leu Phe  Asp Leu Lys 
    3770                 3775                 3780             


Arg Thr  Ser Phe Glu Lys Leu  Ala Lys Leu Asn Leu  Ser Met Ser 
    3785                 3790                 3795             


Thr Leu  Gly Val Trp Thr Arg  His Thr Ser Lys Arg  Leu Leu Gln 
    3800                 3805                 3810             


Asp Cys  Val Asn Val Gly Thr  Lys Glu Gly Asn Trp  Leu Val Asn 
    3815                 3820                 3825             


Ala Asp  Arg Leu Val Ser Ser  Lys Thr Gly Asn Arg  Tyr Ile Pro 
    3830                 3835                 3840             


Gly Glu  Gly His Thr Gln Gln  Gly Lys His Tyr Glu  Glu Leu Val 
    3845                 3850                 3855             


Leu Ala  Arg Lys Pro Thr Ser  Asn Phe Glu Gly Thr  Asp Arg Tyr 
    3860                 3865                 3870             


Asn Leu  Gly Pro Ile Val Asn  Val Val Leu Arg Arg  Leu Arg Val 
    3875                 3880                 3885             


Met Met  Met Ala Leu Ile Gly  Arg Gly Val 
    3890                 3895             


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KRD for GD18 or QZ07 or GD191

<400>  15

Lys Thr Asn Glu Ile Gly Pro Leu Gly Ala Arg Asp 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KARD for GD18 or QZ07 or GD191

<400>  16

Lys Thr Asn Glu Ile Gly Pro Leu Ala Ala Arg Asp 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with RD for GD18 or QZ07 or GD191

<400>  17

Ser Thr Asn Glu Ile Gly Pro Leu Gly Ala Arg Asp 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with RD for C-strain

<400>  18

Ser Thr Asp Glu Ile Gly Leu Leu Gly Ala Arg Asp 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KRD for C-strain

<400>  19

Lys Thr Asp Glu Ile Gly Leu Leu Gly Ala Arg Asp 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated 6B8 epitope with KARD for C-strain

<400>  20

Lys Thr Asp Glu Ile Gly Leu Leu Ala Ala Arg Asp 
1               5                   10          


<210>  21
<211>  12296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-wt

<400>  21
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca aaacaaaatt ccgatttggc       60

ctagggcacc cctccagcga cggccgaact gggctagcca tgcccacagt aggactagca      120

aacggaggga ctagccgtag tggcgagctc cctgggtggt ctaagtcctg agtacaggac      180

agtcgtcagt agttcgacgt gagcaggagc ccacctcgag atgctatgtg gacgagggca      240

tgcccaagac acaccttaac cctggcgggg gtcgccaggg tgaaatcaca ccatgtgatg      300

ggggtacgac ctgatagggc gctgcagagg cccactaaca ggctagtata aaaatctctg      360

ctgtacatgg cacatggagt tgaatcattt tgaactattg tataaaacaa acaaacaaaa      420

accaatggga gtggaggaac cggtgtatga catcgcaggg agaccattat ttggggaccc      480

aagtgaggta cacccacaat caacactgaa gctaccacac gacaggggaa gaggtaatat      540

cagaactaca ctgaaggacc tacctaggaa aggcgactgc aggagtggaa accacctagg      600

accagttagt gggatatacg taaagcctgg ccctgtcttc tatcaggact acatgggccc      660

tgtctaccat agagccccat tagagttttt tggtgaggcc caattttgtg aggtgaccaa      720

gaggataggt agggtgacgg gtagtgacgg aaagctctac cacatatatg tgtgcatcga      780

cggttgcata ctgttgaagt tagccaaaag gggcgcgccc agatccctaa agtggactag      840

gaacttcacc gactgtccac tgtgggtcac tagttgttct gatgatggca caggtgacag      900

caaggataaa aagccagaca ggatgaacaa gggtaaatta aagatagccc caaaagagca      960

tgagaaggac agtaagacca agccacctga tgctacaatt gtggtagagg gagtaaaata     1020

ccaagtaaaa aagaaaggca aagtcaaagg gaagaacact caagatggcc tgtaccataa     1080

taagaacaaa ccaccagagt ccaggaagaa actagaaaaa gccctattgg cctgggcagt     1140

gatagcaata gtgctgtacc agcctgtagc agccgagaat ataacccaat ggaacctgag     1200

tgacaacggc acaagcggca tccagcaagc tatgtatctc agaggggtca ataggagctt     1260

gcatgggatc tggcctgaaa aaatatgcaa gggggtccct actcatctgg ccactgacac     1320

ggaactgaca gagatacgcg ggatgatgga cgccagtgag aggacgaact acacgtgttg     1380

taggttgcag agacacgaat ggaacaaaca tggctggtgc aactggtaca acatagaccc     1440

ctggattcag ttaatgaaca ggacccaagc aaatttgaca gaaggccctc cagataaaga     1500

gtgtgccgtg acttgcaggt atgacaaaaa taccgatgtt aacgtggtca cccaggccag     1560

gaatagacct actactctga ctggctgcaa gaaagggaaa aatttttcat ttgcaggtac     1620

ggtcatagag ggcccatgca atttcaacgt atccgtggag gacatcttat atggcgacca     1680

tgagtgtggc agcctgttcc aggacacggc tctgtaccta ttagatggaa tgaccaacac     1740

tatagagaaa gccaggcagg gtgcggcaag agtcacatct tggctcggga gacaactcag     1800

aaccacaggg aagaagttgg agagaggaag caaaacctgg ttcggtgcct atgccctgtc     1860

accttactgc aatgtaacaa ggaaaatagg gtacatatgg tacacgaaca attgcactcc     1920

ggcatgcctc ccaaaaaaca caaaaataat aggcccagga aagtttgaca ccaatgcaga     1980

agacgggaag attcttcatg aaatgggggg ccacctatca gaattcttgt tgctttctct     2040

ggtagtcctg tctgacttcg ccccagaaac ggccagtaca ttatacctaa tcttacacta     2100

tgcaatccct cagtcccgtg acgaacccga ggtttgcgat acaaaccagc tcaacctaac     2160

agtgggactt aggacagaag atgtggtacc atcatcagtc tggaatattg gcaaatatgt     2220

gtgtgttaga ccagattggt ggccgtatga aactaaggtg gctctactgt ttgaagaggc     2280

gggacaggtc ataaagttag ctctacgggc actgagggat ttaactagag tctggaacag     2340

tgcatcaact actgcgttcc tcatctgctt gataaaaata ttaagaggac aggttgtgca     2400

aggtataata tggctgctgc tggtgactgg ggcacaaggg cggttgtcct gcaaggaaga     2460

ctacaggtat gcgatatcat caaccaatga gatagggccg ctaggggctg aaggtctcac     2520

caccacctgg aaagaatata accatggttt gcagctggat gacgggactg tcagggccat     2580

ttgcactgca gggtccttta aagttatagc acttaatgtg gtcagtagga ggtacctggc     2640

atcattacac aagagggctt tacccacttc agtaacattt gaactcctat ttgatgggac     2700

tagtccagca attgaggaga tgggagatga ctttggattt gggctgtgcc cttttgacac     2760

aacccccgtg gtcaaaggga agtacaatac cactttatta aacggtagtg ctttctatct     2820

agtctgccca ataggatgga cgggtgtcat agagtgcacg gcagtaagcc ctacaacctt     2880

gagaacagaa gtggtgaaga ccttcaagag agagaagcct ttcccacaca gagtgggttg     2940

cgtgaccact gttgtagaaa aagaagacct gttctactgc aagtgggggg gtaattggac     3000

atgtgtaaaa ggcaacccgg tgacctacat gggggggcaa gtaaaacaat gcagatggtg     3060

cggttttgac ttcaaggagc ccgatgggct cccacactac cccataggca agtgcatcct     3120

agcaaatgag acgggttaca gggtagtgga ttccacagac tgcaatagag atggcgtcgt     3180

tatcagcact gaaggtgaac acgagtgctt gattggcaac accaccgtca aggtgcacgc     3240

gttggatgga agactgggcc ctatgccgtg cagacccaaa gaaatcgtct ctagcgcagg     3300

acctgtaagg aaaacttcct gcaccttcaa ctacacaaag acactaagaa acaagtacta     3360

tgaacccagg gacagctatt tccagcaata tatgcttaag ggcgagtacc aatactggtt     3420

tgatctggac gtgaccgacc accacacaga ctactttgcc gaatttgttg tcttggtggt     3480

agtggcacta ttagggggga ggtacgtcct atggctaata gtgacctatg taattttaac     3540

agagcaactc gctgccggtt tacagctggg ccaaggcgag gtagtactga tagggaactt     3600

aattacccac acggacaatg aggtagtggt atacttctta ctgctctacc taataataag     3660

agacgagcct ataaagaaat ggatactact gctgtttcat gccatgacca acaacccagt     3720

taagaccatg acagtagcat tgctgatgat cagtggggtc gccaagggtg ggaaaacaga     3780

tggtggttgg cagaggcagc cggagaccaa ttttgacatt caactcgcac tggcagttat     3840

agtagtcgtt gtgatgttac tggcaaagag agacccgact acttttcccc tggtgatcac     3900

agtggcaacc ttaagaacag ctaagataac caatggtttc agcacagatc tagctatagc     3960

cacagtgtcg gcagctttgc taacctggac ttatatcagt gactactaca aatataagac     4020

ttggctacag tacctcatca gcacggtgac tgggatcttc ctaataaggg tactgaaggg     4080

aataggcgag ctagacatgc acgccccaac tttgccatct cacagacccc ttttctacat     4140

cctcgtgtac ctcatctcca ctgctgtggt gactagatgg aacctggacg tagccggact     4200

gctgctacag tgtgtcccaa cacttctaat ggtgttcacg atgtgggctg acattctcac     4260

cctaatcctc gtgttaccca cttatgaact ggcaaagttg tattacctta aggaagtgaa     4320

gatcggaacc gaaagaggat ggctgtggaa aactaactat aagagggtaa atgacatcta     4380

tgaagtcgac caagctggcg agggggtcta cctcttccct tcgaaacaaa agactagtgc     4440

tataacaagc accatgttgc cattgatcaa agccatactc attagctgca tcagtaacaa     4500

gtggcaactc atatatttac tgtacctgat attcgaagtg tcctactacc ttcacaagaa     4560

agtcatagat gaaatagctg gtgggaccaa cttcgtttca aggctagtgg cagccttaat     4620

tgaagttaat tgggccttcg acaatgaaga agttaaaggc ctaaagaagt tctttttgct     4680

gtccagtaga gttaaagaat tggtcatcaa acacaaagtg aggaatgaag tagtggcccg     4740

ctggttcgga gatgaagaga tctatgggat gcccaagttg atcggcttag tcaaggcagc     4800

aactctaagt aaaaataaac actgtatctt gtgcaccgtc tgcgaggaca gagattggag     4860

aggagaaacc tgcccaaaat gtgggcgttt cggaccacca gtgatctgtg gtatgaccct     4920

agccgacttc gaggagaagc attataagag gatattcatc agggaggacc aatcagatgg     4980

accgctcagg gaggagcgtg cagggtactt acagtacaga gctaggggtc aactgtttct     5040

gaggaatctc ccagtgttgg cgacaaaagt caagatgctc ctggttggta acctcgggac     5100

ggaggttggg gatttggagc accttggctg ggtgcttaga gggcctgctg tctgcaagaa     5160

ggttactgaa catgaaaagt gtgctacgtc tataatggat aagttgactg ctttcttcgg     5220

cgttatgcca agaggtacca cccccagagc ccccgtgaga tttcccacct ccctcctaaa     5280

gataagaaga gggctagaga cgggttgggc ttacacacat caaggtggca ttagctcagt     5340

tgaccatgtg acttgtggga aagacttgct ggtgtgtgac actatgggcc ggacaagggt     5400

cgtttgccaa tcaaataata agatgactga cgaatccgaa tacggggtca aaaccgactc     5460

agggtgccca gaaggggcca gatgttatgt gttcaaccct gaggcagtta acatatcagg     5520

cactaaaggg gccatggtcc acttacaaaa aactggtggg gagttcacct gcgtaacagc     5580

atcaggaacc ccggccttct ttgatctcaa gaacctcaag ggctggtcag ggctaccgat     5640

attcgaagca tcgagtggaa gggtagtcgg aagggtcaag gtcgggaaga acgatgactc     5700

taaaccaacc aaactcatga gtgggataca aacggtctct aaaagtgcca ctgacctgac     5760

ggagatggta aagaagataa caactatgaa caggggagag ttcagacaga taaccttggc     5820

cacaggtgct gggaaaacta cagagctccc caggtcagtc atagaagaga tagggagaca     5880

caaaagggtg ttggtattga tccccttgag ggccgcagca gaatcagtat accaatatat     5940

gaggcagaaa cacccaagta tagcattcaa cctgaggata ggggagatga aggaaggtca     6000

catggccacg gggataacct atgcctccta cggttacttt tgccagatgc cacaacctaa     6060

gctgagggcc gcaatggtag agtactccta catctttcta gatgagtacc attgtgccac     6120

cccagaacaa ctggctatca tggggaagat ccacagattc tcagagaacc tgcgggtggt     6180

agctatgaca gcgacaccag cagggacagt aacaactact gggcagaaac accctataga     6240

ggagttcata gccccggaag taatgaaagg agaagactta ggttcagagt acttagacat     6300

tgccggacta aagataccag tagaggagat gaagaacaac atgctagttt ttgtaccaac     6360

taggaatatg gcggtagagg cggcaaagaa actgaaagct aaaggataca actcaggcta     6420

ttactacagt ggtgaggatc catctaacct gagggtagtc acatcgcagt ccccatacgt     6480

ggttgtagcg accaacgcga tagaatcagg cgtcactctc ccggaccttg acgtggtcgt     6540

tgacacggga ctcaagtgtg agaaaagaat ccgattgtca cccaagatgc ctttcatagt     6600

gactggccta aaaagaatgg ctgttaccat tggggaacaa gcccagagaa gagggagggt     6660

tggaagagta aagcccggga gatactacag gagccaagaa acccctgtcg gctctaagga     6720

ctaccactac gatttattgc aagcccagag gtacggtata gaagatggga taaatatcac     6780

caaatccttc agagaaatga actatgattg gagcctctat gaggaagata gcctgatgat     6840

aacacaattg gaaatcctca acaatctact gatatcagag gagctgccgg tggcagtaaa     6900

aaatataatg gctaggactg accacccaga accaattcaa ctagcatata atagctacga     6960

gacacaagtg cctgtgttgt tcccaaaaat aagaaatgga gaggtgactg acacttacga     7020

tacttacacc ttcatcaatg caagaaaatt gggagatgat gtacctccct acgtgtatgc     7080

cacagaagat gaggacttgg cagtggaact gttgggccta gattggccgg accctgggaa     7140

ccaaggcact gtggaggccg gcagagcact aaaacaggtg gtcggtctat caacagccga     7200

gaatgccctg ttagtagcct tgtttggcta cgtagggtac caggccctct caaagaggca     7260

tatacctgtg gtcacagaca tatactcagt tgaagatcac aggctagagg acaccacaca     7320

cctacagtac gctccgaatg ccatcaagac ggaggggaag gagactgaat tgaaggagtt     7380

ggctcagggg gatgtgcaga gatgcgtgga agcgatgacc aattacgcga gagggggcat     7440

ccaatttatg aagtcacagg cactgcaggt gagagaaacc cccacttata aagagacaat     7500

gaatactgta gcagactatg tgaaaaagtt tatcgaggca ctgtctgata gcaaggaaga     7560

catcttgaaa tatgggctgt ggggcgtaca tacggccttg tacaagagca ttggtgccag     7620

gcttggtcac gaaaccgcgt tcgcaaccct agccgtgaaa tggctggcat ttggggggga     7680

atcaatagca gatcatataa aacaagcggc tacagacttg gtcgtctact atatcatcaa     7740

cagacctcag ttcccaggag acacagagac acaacaggag gggagaaatt ttgtggccag     7800

cctactggtc tcagccctag caacttacac atataaaagc tggaactata ataacctgtc     7860

caagatagta gaaccggctt tggccaccct gccctatgcc gctaaagccc ttaaattatt     7920

tgcccctacc aggctagaga gcgtcgtcat attgagcacc gcaatctaca aaacatacct     7980

atcaatcagg cgaggcaaaa gcgatggatt gctaggtaca ggggttagtg cggctatgga     8040

gattatgtca caaaatccgg tatcagtggg catagcagtt atgctggggg ttggggctgt     8100

agcagcacac aacgcaattg aagccagtga gcagaagaga acactactta tgaaagtttt     8160

tgtaaagaac ttcttggacc aagcagccac agatgaacta gtcaaagaga gccctgagaa     8220

aataataatg gccttgtttg aagcagtgca aacagtaggc aatcctctta ggctagtgta     8280

ccacctttac ggggtttttt ataaagggtg ggaagcaaaa gagttggccc aaaggacagc     8340

cggcaggaat cttttcacct tgataatgtt tgaggccgtg gaactattgg gagtagatag     8400

cgaaggaaaa atccgccaac tatcgagtaa ttacatatta gagctcctgt ataagttccg     8460

tgacagtatc aaatctagtg tgagggagat agcaatcagc tgggcccctg ccccctttag     8520

ttgcgattgg acaccaacag atgacagaat agggcttccc cataacaatt acctccaaat     8580

ggagacaaga tgcccttgtg gctacaggat gaaagcagta aaaacctgtg ctggggagtt     8640

gagacttctg gaagagggag gttcattcct ctgcaggaat aaattcggta gagggtcacg     8700

gaactatagg gtgacaaaat actatgatga caatttatca gaaataaaac cagtgataag     8760

aatggaagga catgtggaac tatattataa gggggccact atcaaactgg actttaacaa     8820

cagtaaaaca gtactggcaa ccgacaaatg ggaggttgac cattccaccc tggtcagggc     8880

gctcaagagg cacacagggg ctgggtacca aggagcgtat atgggtgaga aacctaacca     8940

caaacatctg atagagagag actgtgcaac gatcacaaaa gacaaggttt acttcatcaa     9000

gatgaagagg gggtgtgcgt tcacttatga cttgtccctc cacaacctca cccggttaat     9060

cgaattggta cacaaaaacg acctggaaga tagagaaatc cctgctgtta cggttacaac     9120

ctggctggcc tacacatttg tgaatgaaga catagggacc ataaaaccag tttttgggga     9180

aaaagtaaca ccggaaaaac aggaggaggt agccttgcag cctgctgtgg tggtggacac     9240

aacagatgtg gccgtgaccg tggtggggga aacctctact atgactacag gggagacccc     9300

aacggcattc accagcttag gttcagactc taaagttcaa caagttctga agttaggggt     9360

ggatgagggt caataccccg ggcccagtca gcagagagca agcttgctcg acgctataca     9420

aggcgtggat gaaaggccct cggtattgat attgggatct gataaggcca cctccaatag     9480

ggtgaagacc gcaaagaatg tcaagatatt caggagcaga gaccccctgg aactgagaga     9540

aatgatgaga agagggaaga tcctggtcat agccctatgt aaggtcgaca ctgctctact     9600

gaaatttgtt gattacaaag gcaccttcct gaccagagaa accctagagg cattaagttt     9660

gggtaagcct aagaaaaaaa acataaccaa gacagaggca caatggttgt tgtgcctcga     9720

aaaccaaata gaagagctgc ctgactggtt cgcagctgag gagcccgtat ttctggaagc     9780

caacatcaaa cgtgacaagt atcacctagt gggggatata gctactatca aagaaaaagc     9840

taaacaactg ggggcaacag actccacaaa gatatcaaaa gaggttggag ctaaagtata     9900

ttctatgaag ctgagtaact gggtgataca agaagagaat aaacagggca gcttagcccc     9960

tttgtttgaa gagctcctgc aacagtgccc acctgggggc cagaataaaa ccacacatat    10020

ggtctcagcc taccaactgg ctcaagggaa ctggatgcca gttggttgtc acgtgttcat    10080

ggggaccata cccgccagaa gaaccaagac ccatccctat gaggcatacg tcaagctgag    10140

ggagttggta gatgaatata agatgaagac gctatgtggc ggttcaggcc taagtaagca    10200

caacgaatgg gtaattcgta agatcaagca tcaagggaac ctgaggacca aacacatgtt    10260

gaaccccggg aaggttgcag agcaactgct tagagaagga cacagacaca atgtatataa    10320

taagactata ggctcagtga tgacagcaac tggtatcagg ctggaaaagt tacccgtggt    10380

cagggcccaa acagacacaa ccaacttcca tcaagcaata agggataaaa tagacaagga    10440

agagaactta cagactccag gcttacacaa gaagttaatg gaagtcttca atgcattaaa    10500

aagacccgat cttgaggcct cttacgacgc tgtggagtgg gaggaattgg agaaaggaat    10560

aaataggaag ggtgctgcag gtttctttga acacaagaat ataggagagg ttctggattc    10620

agaaaaaaac aaggttgaag agatcataga cagtttgaga aaaggtagga gtatcaggta    10680

ctatgaaact gcaatcccaa aaaacgagaa gagggacgtc aatgatgact ggactgccgg    10740

tgactttgta gacgagaaaa agcccagggt gatacaatac cctgaggcta aaaccaggtt    10800

ggccatcact aaagtaatgt acaagtgggt gaagcagaaa ccagtagtca tacccggcta    10860

tgaaggtaag acacctctgt tccaaatctt tgacaaagtg aagaaagaat gggaccaatt    10920

ccaaaatcca gtggctgtga gctttgacac caaagcgtgg gacacccagg tgactacagg    10980

agacctggaa ctaataaggg atatacagaa gttctacttc aagaagaagt ggcacaaatt    11040

cattgacacc ctaaccatgc acatgtcaga agtacccgta attagtgccg acggggaggt    11100

gtacataagg aaggggcaga gaggcagtgg acaacctgat acgagcgcag gcaacagcat    11160

gttgaatgta ttaacaatgg tttatgcctt ctgtgaggcc acgggagtgc cctataagag    11220

ttttgacaga gtggcaaaga tccacgtctg cggggatgat ggtttcttga tcactgaaag    11280

ggctcttggt gaaaaatttt cgagtaaagg agtccagatc ctatatgaag ctggtaagcc    11340

ccaaaaaatt acagaagggg ataagatgaa agtggcctac cagtttgatg acatcgagtt    11400

ctgctcccat acaccagtgc aagtaaggtg gtcagacaat acttccagtt atatgccggg    11460

gaggaacacg actacaatcc tggcaaaaat ggctacaagg ttagattcca gtggtgagag    11520

gggcactata gcatatgaga aggcggtggc gtttagcttc ttattgatgt actcctggaa    11580

cccactgatc agaaggatat gcttactggt gttgtcaact gaactgcaag tgagaccagg    11640

gaagtcaacc acctattact atgaagggga cccaatttct gcttacaagg aggtcatagg    11700

ccataatctc tttgacctta aaagaacaag ctttgagaaa ctagctaagt taaatcttag    11760

tatgtccaca ctcggggtat ggaccagaca caccagcaaa agattactac aagactgtgt    11820

caacgtcggc actaaagagg gcaactggct ggttaatgca gacagactgg tgagtagcaa    11880

gacaggaaat aggtatatac ctggagaggg tcatacccag caagggaaac attatgaaga    11940

actgatattg gcaaggaagc cgatcagcaa ttttgaaggg actgatagat acaatttggg    12000

cccaatagtc aacgtagtgt tgaggaggct gagagtcatg atgatggctc ttataggaag    12060

gggggtgtaa gcatggccgg cccttaaccg ggccctatca gtagaaccct gttgtaaata    12120

acactaactt attatttatt taaatactat tatttattta tttatttatt tattgaatga    12180

gcaaggattg gtacaaacta cctcatgtta ccacactaca ctcattttaa cagcacttta    12240

gctggaggga aaatcctgac gtccatagtt ggactaaggt aatttcctaa cggccc        12296


<210>  22
<211>  12299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GD18-wt


<220>
<221>  misc_feature
<222>  (12256)..(12256)
<223>  n is a, c, g, or t

<400>  22
gtatacgagg ttagttcgtt ctcgtgtaca atattggaca agaccaaaat tccgatttgg       60

cctagggcac ccctccagcg acggccgaac tgggctagcc atgcccacag taggactagc      120

aaacggaggg actagccgta gtggcgagct ccctgggtgg tctaagtcct gagtacagga      180

cagtcgtcag tagttcgacg tgagcaggag cccacctcga gatgctatgt ggacgagggc      240

atgcccaaga cacaccttaa ccctggcggg ggtcgccagg gtgaaatcac accatgtgat      300

gggggtacga cctgataggg tgctgcagag gcccactaac aggctagtat aaaaaatctc      360

tgctgtacat ggcacatgga gttgaatcat tttgaactac tatacaaaac aaataaacaa      420

aaaccaatag gagtggagga accggtgtat gacatcgcag gaagaccatt tttcggggac      480

ccaagtgagg tacacccaca atcaacactg aagctgccac atgacagggg gagaggtaat      540

atcagaacta cactgaagaa cctacctagg aaaggcgact gtaggagtgg aaaccaccta      600

ggaccagtca gtgggatata tgtaaaaccc ggccctgtct tctatcagga ctacatgggc      660

cctgtctatc atagagctcc attggagttt tttgaagagg cccagctgtg tgaggtgact      720

aagagaatag gtagggtgac gggtagtgat gggaagcttt accacatata tgtgtgcatt      780

gacggttgca tactgctgaa gttagccaaa aggggcacgc ctagatccct aaagtggact      840

aggaacttca ccgactgtcc actatgggtc actagttgtt ctgatgatgg cgcaggtggc      900

agcaaggata agaaaccaga caggatgaac aagggtaaat taaaaatagc cccaaaagag      960

catgagaagg acagcaaaac caagccacct gatgccacga tcgtggtaga gggagtaaaa     1020

taccaagtga aaaagaaagg caaagtcaaa gggaagaaca ctcaagatgg cctataccat     1080

aataagaaca aaccaccaga gtccaggaag aaactagaaa aagccctact ggcttgggca     1140

gtgataacaa tcgtactgta ccagcctgta gcggccgaga atataactca gtggaacctg     1200

agtgacaatg gcacaagcgg tatccagcaa gccatgtatc ttagaggggt taataggagt     1260

ctacatggga tctggcctga aaaaatatgc aaaggggtcc ctactcacct ggctactgat     1320

acggagctga cagagatacg agggatgatg gacgccagcg agaggacaaa ctatacgtgt     1380

tgcaggttgc agagacacga atggaataaa catggatggt gtaactggta caacatagac     1440

ccctggattc aattaatgaa caggacccaa gcaaatctga cagaaggccc cccggataag     1500

gagtgcgccg tgacttgcag gtatgacaaa aatgctgacg ttaacgtggt cacccaggcc     1560

aggaatagac caaccactct gaccggctgc aagaaaggaa aaaacttttc atttgcaggt     1620

acgattatag agggcccatg caatttcaac gtctccgtgg aggacatcct atatggggac     1680

catgagtgtg gcagcctgtt ccaggacaca gctctgtacc tattagatgg aatgaccaac     1740

actatagaga aagccaggca gggtgcggca agagttacat cctggcttgg gaggcaactc     1800

agcaccacag ggaagaagtt ggagagagga agcaaaacct ggttcggcgc ctacgccctg     1860

tcaccttact gtaacgtaac aaggaaagtg gggtacatat ggtatacgaa caattgcact     1920

ccggcatgtc tcccaaaaaa cacgaaaata ataggtccag gaaaattcga taccaacgcg     1980

gaagatggga agatacttca tgaaatgggg ggccacctat cagaattttt gttgctttct     2040

ttagtaatcc tgtctgactt cgccccggag acggccagta cgctatacct aatcttacac     2100

tatgcaatcc ctcagtccca tgaagagcct gaaggttgcg atacgaacca gctcaatcta     2160

acagtgggac ttaggacaga agatgtggta ccatcatcag tttggaatat cggcaaatat     2220

gtgtgtgtca gaccagactg gtggccgtat gaaactaagg tggctttgct gtttgaggag     2280

gcaggacagg ttataaaact agctctacgg gcactgagag atttaactag agtctggaac     2340

agtgcatcaa ctactgcgtt cctcatctgc ttgataaaaa tattaagagg acaggttgtg     2400

caaggtataa tatggctgct gctggtaact ggggcacaag ggcggttgac ctgtaaggaa     2460

gactacaggt atgcgatatc atcaaccaat gagatagggc cgcttggagc tgaaggtctc     2520

actaccacct ggaaagaata caaccatggt ttacagctgg atgacgggac tgtcagggcc     2580

acttgcactg cagggtcctt taaagttata gcacttaatg tggttagtag gaggtacctg     2640

gcatcattac acaagagggc tttgcccacc tcagtaacat ttgaactcct atttgatggg     2700

accagcccag taattgagga gatgggagac gactttggat ttgggctgtg cccttttgac     2760

acgatccctg tggtcaaagg gaagtataac accaccttat taaacggcag tgctttctat     2820

ctagtctgcc ctataggatg gacgggtgtt atagagtgca cggcagtaag ccccacaacc     2880

ttgagaacag aagtggtgaa gaccttcaag agagagaagc ctttccctca cagagtggac     2940

tgcgtgacca ctatagtaga aaaagaagac ctgttctatt gcaggctggg gggtaattgg     3000

acatgcgtga aaggtgaccc ggtgacctac acggggggcc aagtaaaaca atgcaggtgg     3060

tgcggtttca acttcaagga gcctgatggg ctcccacact accccatagg caagtgcatc     3120

ctagcaaatg agacgggata cagggtagtg gactccacag actgcaacag agacggcgtc     3180

gtcatcggca ctgaaggaga gcatgagtgc ttgatcggca acaccaccgt caaggtgcac     3240

gcgctggacg gaagactggc ccctatgcct tgcagaccca aagaaatcgt atctagtgcg     3300

ggacctgtaa ggaaaacttc ctgcacattt aactatacaa agactttgag gaacaagtac     3360

tatgagccca gggacagcta cttccagcaa tacatgctta agggcgagta tcaatactgg     3420

tttgatctgg acgtgacaga ccaccacaca gactacttcg ccgagtttgt tgtcttggtg     3480

gtagtggcac tattaggggg aaggtacgtc ctgtggctaa tagtgaccta tatagttcta     3540

acagagcaac tcgctgctgg tttacagcta ggccagggcg aggtggtgct gatagggaac     3600

ttaatcaccc acatggacaa cgaggtagtg gtatacttct tactgcttta cctaataata     3660

agagacgagc ccataaagaa atggatacta ctgctgttcc atgccatgac caacaaccca     3720

gttaagacca tgacagtagc attgctaatg ataagcgggg tagccaaggg tgggaaaata     3780

gatggtggtt ggcagaggca gccggagacc aattttgaca tccaattcgc actggcagtc     3840

ataatagtcg tcgtgatgtt gttggcaaag agagatccga ctacttttcc cctggtgatc     3900

actgtggcaa ccttgagaac ggctaagata accagtggtt tcagcacaga tctagccata     3960

gccacagtgt cggcaacttt gctaacctgg acttatatca gtgactacta caaatacaag     4020

acttggctac agtacctcat cagcacggtg actggaattt ttctgataag ggtactgaag     4080

ggggtcggcg agttggacct acacgccccg actctgccat cccacagacc ccttttctac     4140

atccttgtgt acctcatctc cactgccgtg gtaacgagat ggaacttgga cgtagccgga     4200

atactgctac agtgcgcccc aacacttcta atggtattca cgatgtgggc tgacatcctc     4260

accctaattc tcatactgcc cacctatgag ttgacaaagt tatattacct taaggaagtg     4320

aagataggga ctgaaagagg atggctgtgg aaaactaatt acaagagggt aaatgacatc     4380

tatgaagtcg accaagctgg cgaaggggtt tacctcttcc cttcgaaaca aaagactgga     4440

gctataacga gcaccgtgtt gccgttgatc aaagccatac tcattagctg catcagtaac     4500

aagtggcaat tcatatattt actgtacttg atatttgagg tgtcctacta ccttcacaag     4560

aaaatcatag atgagatagc cggcgggacc aacttcgttt cgagactagt ggcggcttta     4620

attgaagtta attgggctct agacaatgaa gaagtcaaag gcctaaagaa gtttttcttg     4680

ttgtctagta gggtcaaaga gttggttatc aaacacaaag tgaggaatga agtaatggtc     4740

cgctggtttg aagatgaaga gatctacggg atgccaaagc tgatcggcct ggttaaggca     4800

gcaacactga gcaaaaacaa acactgtatt ttgtgcaccg tctgtgagga cagagattgg     4860

cggggagaaa cttgcccgaa atgcgggcgt tttggaccac cagtgatctg tggtatgacc     4920

ctagctgact tcgaggaaaa acactataag aggattttca tcagggagga ccaatcagac     4980

gggccgctca gggaggagca tgcagggtac ttgcagtaca aagctagggg tcaattgttt     5040

ctgaggaatc tcccagtgtt ggcaacaaaa gtcaagatgc ttctggttgg caacctaggg     5100

acagaggttg gggacctgga gcaccttggc tgggtgctca gagggcccgc tgtctgcaag     5160

aaggttactg aacatgaaaa gtgtgctacg tctataatgg ataagttgac tgccttcttt     5220

ggtgtcatgc caaggggtac cacccccaga gctcctgtaa gatttcccac ctcccttcta     5280

aagataagaa gagggctgga gacgggttgg gcttatacac accaaggcgg tatcagctca     5340

gttgaccatg ttacttgcgg gaaagacctg ctagtgtgtg acaccatggg tcggacaagg     5400

gttgtctgcc aatcgaataa caagatgact gacgagtctg aatacggagt caaaaccgac     5460

tcagggtgcc cagagggagc caggtgctac gtgttcaacc ctgaggcagt taatatatca     5520

ggcactaaag gagccatggt ccacttacag aaaactggtg gagaattcac ctgtgtaaca     5580

gcatcaggga ccccagcttt cttcgatctc aagaacctca agggttggtc agggctaccg     5640

atatttgaag catcgagtgg aagggtagtc ggaagggtca aggtcgggaa gaacgaagac     5700

tctaaaccaa ccaaactcat gagtgggata caaacggtct ctaaaagtgc cactgatttg     5760

acggagatgg tgaagaagat aacaaccatg aacagggggg agttcagaca aataaccttg     5820

gccacaggtg ctggaaaaac tacagagcta cccaggtcag tcatagaaga gatagggaga     5880

cacaaaaggg tgctggtatt gatccccctt agggccgcag cagaatcagt ataccaatac     5940

atgaggcaga aacacccgag tatagcattc aacctgagga taggggagat ggaggaagga     6000

tacatggcca cgggaataac ctatgcttct tatggttact tttgccagat gccacaaccc     6060

aagttgagag ccgcaatggt agagtattcc tacatctttc tagacgagta ccattgcgcc     6120

accccggaac aattggctat catggggaag atccacagat tctcagagaa cctgcgggtg     6180

gtcgctatga cagcgacgcc ggcaggcacg gtaacaacta ctgggcagaa acaccctata     6240

gaggagttca tagccccgga agtgatgaaa ggagaagact taggttcaga gtacttagac     6300

atcgccggac taaagatacc agtagaggag atgaagaaca acatgctagt ttttgtacca     6360

actaggaaca tggcagtgga ggcggcaaag aaattgaaag ccaaaggata taactcaggc     6420

tattactaca gtggtgagga cccatccaac ctgagggtag ttacatcgca gtccccatac     6480

gtggtggtag cgaccaacgc aatagaatca ggcgtcactc tcccagacct tgatgtggtc     6540

gttgacacag gactcaagtg tgagaaaaga atccgactgt cacccaagat gcctttcata     6600

gtgactggcc tgaaaagaat ggccgtcact attggggaac aagcccagag aagagggagg     6660

gttggaagag taaagcccgg gagatactac aggagccaag aaactccagt cggctctaag     6720

gactaccact atgacttgct gcaagcccaa aggtacggta tagaagatgg gataaatatc     6780

accaaatcct tcagagagat gaactacgat tggagccttt atgaggaaga tagcctgatg     6840

ataacacaac tggaaatcct caacaatctg ttgatatcag aggagctgcc ggtagcagta     6900

aaaaatataa tggctaggac tgaccaccca gaaccaattc aactagcgta taatagctac     6960

gagacacagg taccagtgtt gttcccaaag ataaggaatg gagaggtgac tgacacttac     7020

gacaactaca ccttcctcaa tgcaagaaaa ttgggagatg atgtaccccc ctatgtgtat     7080

gccacagaag atgaggactt ggcagtggaa ctgttaggcc tagattggcc agaccctgga     7140

aaccaaggca ctgtggaggc tggcagagca ctaaaacagg tggtcggcct atcaacagcc     7200

gagaatgccc tgctagtggc cttgtttggc tacgtagggt accaggccct ctcaaaaagg     7260

catatacctg tagtcacaga catatattca gttgaagatc acaggttgga agatacaaca     7320

cacctacagt atgccccgaa cgccatcaag acggagggga aggagactga attgaaggag     7380

ttggctcaag gggatgtgca gagatgtgtg gaagcagtgg ccaattatgc gagtgagggc     7440

atccaattta ttaagtcaca ggcactgaag gtgagagaga ccccgactta caaagagaca     7500

atgaatacag tggcagacta tgtgaaaaag ttcattgagg cactgtcaga tagcaaggaa     7560

gacatcttga aatatgggct gtggggtgta cacacggcct tgtataagag cattggtgcc     7620

agactaggtc acgaaactgc gttcgcaact ttagtcgtga aatggttggc atttgggggg     7680

gaatcagtaa cagatcacat aaagcaagca gccacagact tggttgttta ctatattatc     7740

aacagacctc aattcccagg ggacacggag acacaacaag aagggaggaa atttgtggcc     7800

agcttactgg tctcagccct agcaacctac acatacaaaa gctggaacta caacaatctg     7860

tccaagatag ttgaacctgc tttggccact ttgccctacg ccgccaaagc ccttaaatta     7920

ttcgccccta cccgactgga gagcgtcgtc atattgagca ccgcaatcta caaaacatat     7980

ctatcaatca ggcgaggcaa aagtgatgga ttgcttggta caggggttag tgcggctatg     8040

gagattatgt cacaaaatcc agtatcagtg ggcatagcag tcatgctggg ggttggggct     8100

gtagcagccc ataatgcaat tgaagccagt gagcagaaga gaacactact aatgaaagtc     8160

tttgtgaaaa acttcttgga ccaagcagcc acggatgaac tagtcaaaga gagccctgag     8220

aaaataataa tggccctgtt tgaagcagtg cagacggtag gcaaccctct cagactggtg     8280

taccacctat atggagtttt ttataaaggg tgggaagcaa aagagttggc ccaaaggaca     8340

gccggcagga acctcttcac cttaataatg ttcgaggctg tggaactact gggagtagat     8400

agtgaaggga aaatccgcca gctctcaagt aactacatat tagagctcct gtacaagttc     8460

cgtgacgaca tcaaatctag tgtgagggag atagcaatca gttgggcccc tgcccccttc     8520

agctgcgact ggacaccaac agatgacaga ataggacttc cccatgacaa ttatctccag     8580

atggagacaa gatgtccttg tggttacagg atgaaagcag taaaaacctg tgccggggag     8640

ttgagactcc tggaagaggg gggttcattc ctctgcagga ataaattcgg cagagggtca     8700

cggaattata gggtgacaaa atattatgat gacaacttat cagaaataaa accagtgata     8760

agaatggaag gacacgtgga actgtatcat aaaggggcca ctttcaaact ggactttgac     8820

aacagtaaaa cagtactggc aacagataga tgggaagtcg accattccac cctgatcagg     8880

gtgctcaaga ggcacacagg ggctggattt caaggggcgt atctgggtga gaaacccaat     8940

cacaagcacc tgatagagag agactgtgca acgatcacaa aagacaaggt ctgcttcatc     9000

aaaatgaaga gggggtgcgc gttcacctat gacttatcac tccacaacct tacccggcta     9060

atcgaattgg tacataagaa caacctggat gacagagaaa tccctgccgt tacggtcaca     9120

acctggctgg cctacacatt cgtgaatgaa gacataggga ccataaaacc agtcttcggg     9180

gaaaaagtaa caccggagaa gcaggaggag gtagccttgc agcctgcagt ggtggtggac     9240

acaacagatg tggccgtgac cgtggtgggg gaaacctcca ctatgaccac aggggagacc     9300

cccacaatat ttaccagctt aggttcggac tctaagtttc aacaagtcct gaaactgggg     9360

gtggatgagg gtcaatatcc cgggcccagg cagcagagag caagtttgct cgaagctgta     9420

caaggtgtag atgagaggcc ctcggtacta atattggggt ctgataaggc cacctccaat     9480

agggtgaaga ccgcaaagaa tgtgaagata ttcaggagca gagaccccct ggaactgaga     9540

gagatgatga gaagagggaa gatcctaatc atagccctgt gtaaggtgga caccgctctg     9600

ctgaaatttg ttgattacaa aggtaccttc ctgaccagag agaccctaga ggcattaagt     9660

ctgggcaaac ctaagaaaag agacataact aagacagagg cacgatggtt gttgtgcctc     9720

gaaggtcaat tagaagagct gcctgactgg tttgcagcca aggagcccat attcttagaa     9780

gccaacatca aacgtgacaa gtatcatctg gtgggagaca tagctacaat caaagaaaaa     9840

gccaagcaac tgggggcaac agactccaca aagatatcaa aagaggttgg cgcgaaagtg     9900

tattctatga agttgagtaa ctgggtgata caggaagaga ataaacaggg cagcttaacc     9960

cccttgtttg aagagctcct gcaacagtgc ccgcccgggg gccagaataa aaccacacat    10020

atggcctcag cctaccaatt ggctcagggg aactggatgc cagttggttg ccacgtgttc    10080

atggggacca tacccgctag aagaaccaag actcatccct acgaggcata tgtcaagttg    10140

agggagttgg tggaagaaca taagatgaag acatcatgtg gcggttcagg cctatgtaag    10200

cacaacgaat gggtaattcg taagatcaag catcaaggga acctgaggac cagacacatg    10260

ctgaaccccg gaaagattgc tgagcaactg gatagagaag ggcacagaca caatgtgtac    10320

aacaagacca taggctcagt aatgacagcg actggcatca ggctggaaaa gttacccgtg    10380

gttagagccc agacagatac aactaatttc caccaagcaa taagggataa aatagacaag    10440

gaagagaacc tacagacccc aggcttacac aagaagttaa tggaggtatt caatgcatta    10500

aaaagacctg agcttgaggc ctcttacgac gccgtggagt gggaggaatt ggagagagga    10560

ataaatagga agggtgctgc agggttcttc gaacgcaaga atataggaga ggtcctagat    10620

tcagaaaaat ataaggttga agagatcata gacagtttga agaaaggtag gagtattaaa    10680

tattatgaaa ctgcaatccc aaagaacgaa aagagggatg tcaatgatga ctggactgcc    10740

ggagactttg tggatgagaa aaaacccagg gtgatacaat atcctgaggc caaaaccagg    10800

ttagccatca ctaaagtgat gtataagtgg gtgaaacaga aaccagtagt catacccggc    10860

tatgaaggta agacacctct gttccaaatt tttgacaaag tgaaaaaaga atggaaccaa    10920

ttccaaaatc cagtggcagt gagctttgac actaaagcat gggataccca ggtgactaca    10980

agagacctgg aactaataag ggatatacag aagttctatt tcaagaagaa gtggcacaaa    11040

ttcatcgaca ccctaaccat gcacatgtca gaagtacccg tgattagtgc cgacggggag    11100

gtgtatataa ggaaagggca gagaggcagt gggcaacctg atacgagcgc aggcaacagt    11160

atgctgaatg tgttaacaat ggtttatgcc ttctgtgagg ccacgggggt accctataaa    11220

agtttcgaca gagtggcaaa gatccacgtc tgtggggatg atggcttctt gattactgaa    11280

agggctcttg gtgaaaaatt tgcaagtaga ggagtccaga tcctatatga agccgggaag    11340

ccccaaaaaa tcactgaagg ggacaatatg aaagtggcct atcagtttga cgacatcgag    11400

ttctgctccc atacaccagt gcaggtaagg tggtcagaca acacctccag ttacatgccg    11460

gggaggaaca caaccacaat actggcaaaa atggctacaa ggttggattc cagtggtgag    11520

agaggcacta tagcatatga gaaggcagtg gcattcagtt tcttgttgat gtactcctgg    11580

aacccactga ttagaaggat atgcttattg gtgttatcaa ctgaaatgca agtgagacca    11640

gggaagtcaa ccacctatta ctatgaagga gacccaatat ctgcttacaa ggaggtcatc    11700

ggccataatc tctttgacct taaaagaaca agtttcgaga agctagctaa gctaaatctt    11760

agtatgtcca cactcggggt atggaccagg cataccagca aaagattact acaagactgt    11820

gtcaatgtcg gcaccaaaga gggcaactgg ctggttaacg cagacagact ggtgagtagt    11880

aagacaggga ataggtatat acctggagag ggtcataccc aacaaggaaa acattatgaa    11940

gagctggtat tggcaagaaa accgaccagt aattttgaag ggactgatag atataatttg    12000

ggcccaatag tcaacgtagt gttgaggagg ctgagagtca tgatgatggc tcttatagga    12060

aggggggtgt gagagcggcc ggctcttgac cgggccctat cagtataacc ctgttgtaaa    12120

taacactaac ttattattta tctagacact actatttatt tatttattta tttattgaat    12180

gagcaaggaa tggtacgaac tacctcatgt taccacacta cactcatttt aacagcactt    12240

tagctgagga aaaaantcct gacgtccata gttggactaa ggtaatttcc taacggccc     12299


<210>  23
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KRD for QZ07

<400>  23

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Ile Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  24
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KARD for QZ07

<400>  24

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Ile Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  25
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with RD for QZ07

<400>  25

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Ile Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  26
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with RD for GD18

<400>  26

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  27
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KRD for GD18

<400>  27

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  28
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KARD for GD18

<400>  28

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  29
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-strain E2

<400>  29

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Gly Ala Gly Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala Thr Asp Arg His Ser 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  30
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with RD for C-strain

<400>  30

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala Thr Asp Arg His Ser 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  31
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KRD for C-strain

<400>  31

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala Thr Asp Arg His Ser 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  32
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KARD for C-strain

<400>  32

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala Thr Asp Arg His Ser 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Val Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Val Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  33
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KRD for QZ07

<400>  33

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  34
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KARD for QZ07

<400>  34

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  35
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with RD for QZ07

<400>  35

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Ala Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Gly Cys Val Thr Thr Val Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Trp Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Met Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  36
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with RD for GD18

<400>  36

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  37
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KRD for GD18

<400>  37

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  38
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KARD for GD18

<400>  38

Arg Leu Thr Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Thr Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Ser Pro Val Ile Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Ile Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Arg Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asp 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asn Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Gly Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  39
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with RD for C-strain

<400>  39

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala 
                325                 330     


<210>  40
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KRD for C-strain

<400>  40

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala 
                325                 330     


<210>  41
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KARD for C-strain

<400>  41

Arg Leu Ala Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asp 
1               5                   10                  15      


Glu Ile Gly Leu Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Asp Leu Gln Leu Asn Asp Gly Thr Val Lys Ala Ser Cys 
        35                  40                  45              


Val Ala Gly Ser Phe Lys Val Ile Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Lys Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Asn Pro Ser Thr Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Arg Ser Gly Leu Cys Pro Phe Asp Thr Ser Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Pro 
    130                 135                 140                 


Thr Thr Leu Arg Thr Glu Val Val Lys Thr Phe Arg Arg Asp Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Met Asp Cys Val Thr Thr Thr Val Glu Asn Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Glu 
            180                 185                 190         


Pro Val Val Tyr Thr Gly Gly Val Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Asp Gly Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Ala Asn Glu Thr Gly Tyr Arg Ile Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Ser His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Ser Asp Glu Arg Leu 
            260                 265                 270         


Gly Pro Met Pro Cys Arg Pro Lys Glu Ile Val Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Lys Asn 
    290                 295                 300                 


Arg Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Ala 
                325                 330     


<210>  42
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD191 E2

<400>  42

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Glu Gly Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Ile Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  43
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with RD for GD191

<400>  43

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Ile Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  44
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KRD for GD191

<400>  44

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Ile Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  45
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated E2 with KARD for GD191

<400>  45

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp Val Thr Asp His His Thr 
                325                 330                 335     


Asp Tyr Phe Ala Glu Phe Ile Val Leu Val Val Val Ala Leu Leu Gly 
            340                 345                 350         


Gly Arg Tyr Val Leu Trp Leu Ile Val Thr Tyr Ile Val Leu Thr Glu 
        355                 360                 365             


Gln Leu Ala Ala Gly 
    370             


<210>  46
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with RD for GD191

<400>  46

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Ser Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  47
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KRD for GD191

<400>  47

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Gly Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  48
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated and mutated E2 with KARD for GD191

<400>  48

Arg Leu Ser Cys Lys Glu Asp Tyr Arg Tyr Ala Ile Ser Lys Thr Asn 
1               5                   10                  15      


Glu Ile Gly Pro Leu Ala Ala Arg Asp Leu Thr Thr Thr Trp Lys Glu 
            20                  25                  30          


Tyr Asn His Gly Leu Gln Leu Asp Asp Gly Thr Val Arg Ala Ile Cys 
        35                  40                  45              


Thr Ala Gly Ser Phe Lys Val Thr Ala Leu Asn Val Val Ser Arg Arg 
    50                  55                  60                  


Tyr Leu Ala Ser Leu His Lys Arg Ala Leu Pro Thr Ser Val Thr Phe 
65                  70                  75                  80  


Glu Leu Leu Phe Asp Gly Thr Thr Pro Ala Val Glu Glu Met Gly Asp 
                85                  90                  95      


Asp Phe Gly Phe Gly Leu Cys Pro Phe Asp Thr Thr Pro Val Val Lys 
            100                 105                 110         


Gly Lys Tyr Asn Thr Thr Leu Leu Asn Gly Ser Ala Phe Tyr Leu Val 
        115                 120                 125             


Cys Pro Ile Gly Trp Thr Gly Val Ile Glu Cys Thr Ala Val Ser Lys 
    130                 135                 140                 


Asp Thr Leu Arg Thr Glu Val Val Lys Thr Phe Lys Arg Glu Lys Pro 
145                 150                 155                 160 


Phe Pro His Arg Val Asp Cys Val Thr Thr Ile Val Glu Lys Glu Asp 
                165                 170                 175     


Leu Phe Tyr Cys Lys Leu Gly Gly Asn Trp Thr Cys Val Lys Gly Asn 
            180                 185                 190         


Pro Val Thr Tyr Thr Gly Gly Gln Val Lys Gln Cys Arg Trp Cys Gly 
        195                 200                 205             


Phe Asp Phe Lys Glu Pro Asp Gly Leu Pro His Tyr Pro Ile Gly Lys 
    210                 215                 220                 


Cys Ile Leu Val Asn Glu Thr Gly Tyr Arg Val Val Asp Ser Thr Asp 
225                 230                 235                 240 


Cys Asn Arg Asp Gly Val Val Ile Ser Thr Glu Gly Glu His Glu Cys 
                245                 250                 255     


Leu Ile Gly Asn Thr Thr Val Lys Val His Ala Leu Asp Gly Arg Leu 
            260                 265                 270         


Ala Pro Met Pro Cys Arg Pro Lys Glu Ile Ile Ser Ser Ala Gly Pro 
        275                 280                 285             


Val Arg Lys Thr Ser Cys Thr Phe Asn Tyr Thr Lys Thr Leu Arg Asn 
    290                 295                 300                 


Lys Tyr Tyr Glu Pro Arg Asp Ser Tyr Phe Gln Gln Tyr Met Leu Lys 
305                 310                 315                 320 


Gly Glu Tyr Gln Tyr Trp Phe Asp Leu Asp 
                325                 330 


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide- 16 aa for C strain

<400>  49

Ile Val Gln Gly Val Val Trp Leu Leu Leu Val Thr Gly Ala Gln Gly 
1               5                   10                  15      


<210>  50
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-21 aa for QZ07 and GD18

<400>  50

Ile Leu Arg Gly Gln Val Val Gln Gly Ile Ile Trp Leu Leu Leu Val 
1               5                   10                  15      


Thr Gly Ala Gln Gly 
            20      


<210>  51
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-21 aa for GD191

<400>  51

Val Leu Arg Gly Gln Val Val Gln Gly Val Ile Trp Leu Leu Leu Val 
1               5                   10                  15      


Thr Gly Ala Gln Gly 
            20      


<210>  52
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-E2-DNA for BACULO-EXPRESSION

<400>  52
atgatcctgc gtggtcaggt ggtccagggc atcatctggc tcctgctcgt gactggtgct       60

cagggaaggc tgtcttgcaa ggaagactac cgttacgcta tctccagcac caacgaaatc      120

ggacctctcg gtgctgaggg actgaccact acctggaagg agtacaacca cggactgcaa      180

ctggacgacg gtactgtgcg cgctatctgc accgccggtt ccttcaaggt catcgctctg      240

aacgtggtct cccgccgtta cctggctagc ctgcacaagc gtgccctgcc cacttctgtg      300

accttcgaac tgctgttcga cggtacctca ccagccatcg aggaaatggg cgacgacttc      360

ggcttcggac tgtgcccttt cgacactacc cccgtggtca agggaaagta caacactacc      420

ctgctgaacg gttccgcttt ctacctggtc tgccctatcg gatggactgg tgtgatcgag      480

tgcaccgccg tcagccccac taccctgagg actgaagtgg tcaagacctt caagagggag      540

aagcctttcc cccacagagt gggatgcgtc actaccgtgg tcgagaagga agacctgttc      600

tactgcaagt ggggtggcaa ctggacttgc gtgaagggca acccagtcac ctacatggga      660

ggtcaagtga agcagtgcag atggtgcgga ttcgacttca aggaacctga cggcctgccc      720

cactacccaa tcggaaagtg catcctggct aacgagactg gctacagggt ggtcgactcc      780

accgactgca acagagacgg tgtggtcatc agcaccgagg gcgaacacga gtgcctgatc      840

ggaaacacta ctgtgaaggt ccacgctctg gacggaaggc tgggaccaat gccttgccgt      900

ccaaaggaaa tcgtgtcttc agccggtcct gtccgcaaga cttcttgcac cttcaactac      960

actaagaccc tgaggaacaa gtactacgaa cctagagact catacttcca gcagtacatg     1020

ctgaagggcg agtaccagta ctggttcgac ctggacgcgg gttcgggtgg ctcaggtcat     1080

catcatcatc atcac                                                      1095


<210>  53
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-E2-KRD- DNA for BACULO-EXPRESSION

<400>  53
atgatcctgc gtggtcaggt ggtccagggc atcatctggc tcctgctcgt gactggtgct       60

cagggaaggc tgtcttgcaa ggaagactac cgttacgcta tctccaagac caacgaaatc      120

ggacctctcg gtgctagaga cctgaccact acctggaagg agtacaacca cggactgcaa      180

ctggacgacg gtactgtgcg cgctatctgc accgccggtt ccttcaaggt catcgctctg      240

aacgtggtct cccgccgtta cctggctagc ctgcacaagc gtgccctgcc cacttctgtg      300

accttcgaac tgctgttcga cggtacctca ccagccatcg aggaaatggg cgacgacttc      360

ggcttcggac tgtgcccttt cgacactacc cccgtggtca agggaaagta caacactacc      420

ctgctgaacg gttccgcttt ctacctggtc tgccctatcg gatggactgg tgtgatcgag      480

tgcaccgccg tcagcaagga caccctgagg actgaagtgg tcaagacctt caagagggag      540

aagcctttcc cccacagagt gggatgcgtc actaccgtgg tcgagaagga agacctgttc      600

tactgcaagt ggggtggcaa ctggacttgc gtgaagggca acccagtcac ctacatggga      660

ggtcaagtga agcagtgcag atggtgcgga ttcgacttca aggaacctga cggcctgccc      720

cactacccaa tcggaaagtg catcctggct aacgagactg gctacagggt ggtcgactcc      780

accgactgca acagagacgg tgtggtcatc agcaccgagg gcgaacacga gtgcctgatc      840

ggaaacacta ctgtgaaggt ccacgctctg gacggaaggc tgggaccaat gccttgccgt      900

ccaaaggaaa tcgtgtcttc agccggtcct gtccgcaaga cttcttgcac cttcaactac      960

actaagaccc tgaggaacaa gtactacgaa cctagagact catacttcca gcagtacatg     1020

ctgaagggcg agtaccagta ctggttcgac ctggacgcgg gttcgggtgg ctcaggtcat     1080

catcatcatc atcac                                                      1095


<210>  54
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QZ07-E2-KARD- DNA for BACULO-EXPRESSION

<400>  54
atgatcctgc gtggtcaggt ggtccagggc atcatctggc tcctgctcgt gactggtgct       60

cagggaaggc tgtcttgcaa ggaagactac cgttacgcta tctccaagac caacgaaatc      120

ggacctctcg cagctagaga cctgaccact acctggaagg agtacaacca cggactgcaa      180

ctggacgacg gtactgtgcg cgctatctgc accgccggtt ccttcaaggt catcgctctg      240

aacgtggtct cccgccgtta cctggctagc ctgcacaagc gtgccctgcc cacttctgtg      300

accttcgaac tgctgttcga cggtacctca ccagccatcg aggaaatggg cgacgacttc      360

ggcttcggac tgtgcccttt cgacactacc cccgtggtca agggaaagta caacactacc      420

ctgctgaacg gttccgcttt ctacctggtc tgccctatcg gatggactgg tgtgatcgag      480

tgcaccgccg tcagcaagga caccctgagg actgaagtgg tcaagacctt caagagggag      540

aagcctttcc cccacagagt gggatgcgtc actaccgtgg tcgagaagga agacctgttc      600

tactgcaagt ggggtggcaa ctggacttgc gtgaagggca acccagtcac ctacatggga      660

ggtcaagtga agcagtgcag atggtgcgga ttcgacttca aggaacctga cggcctgccc      720

cactacccaa tcggaaagtg catcctggct aacgagactg gctacagggt ggtcgactcc      780

accgactgca acagagacgg tgtggtcatc agcaccgagg gcgaacacga gtgcctgatc      840

ggaaacacta ctgtgaaggt ccacgctctg gacggaaggc tgggaccaat gccttgccgt      900

ccaaaggaaa tcgtgtcttc agccggtcct gtccgcaaga cttcttgcac cttcaactac      960

actaagaccc tgaggaacaa gtactacgaa cctagagact catacttcca gcagtacatg     1020

ctgaagggcg agtaccagta ctggttcgac ctggacgcgg gttcgggtgg ctcaggtcat     1080

catcatcatc atcac                                                      1095


<210>  55
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C strain-E2-DNA for BACULO-EXPRESSION

<400>  55
atgatcgtgc aaggtgtggt atggctgtta ctagtaactg gggcacaagg ccggctagcc       60

tgcaaggaag attacaggta cgcaatatcg tcaaccgatg agatagggct acttggggcc      120

ggaggtctca ccaccacctg gaaggaatac aaccacgatt tgcaactgaa tgacgggacc      180

gtcaaggcca gttgcgtggc aggttccttt aaagtcatag cacttaatgt ggtcagtagg      240

agatatttgg cgtcattgca taagaaggct ttacccactt ccgtgacatt cgagctcctg      300

ttcgacggga ccaacccatc aactgaggaa atgggagatg acttcaggtc cgggctgtgc      360

ccgtttgata cgagtcccgt tgttaaggga aagtacaata cgaccttgtt gaacggtagt      420

gctttctatc ttgtctgccc aatagggtgg acgggtgtca tagagtgcac agcagtgagc      480

ccaacaactc tgaggacaga agtggtaaag accttcagga gagacaagcc ctttccgcac      540

agaatggatt gtgtgaccac cacagtggaa aatgaagatt tattctattg taagttgggg      600

ggcaactgga catgtgtgaa aggcgagcca gtggtctaca cagggggggt agtaaaacaa      660

tgtagatggt gtggcttcga cttcgatggg cctgacggac tcccgcatta ccccataggt      720

aagtgcattt tggcaaatga gacaggttac agaatagtag attcaacgga ctgtaacaga      780

gatggcgttg taatcagcac agaggggagt catgagtgct tgatcggtaa cacgactgtc      840

aaggtgcatg catcagatga aagactgggc cctatgccat gcagacctaa agagattgtc      900

tctagtgctg gtcctgtaag gaaaacctcc tgtacattca actacacaaa aactttgaag      960

aacaggtact atgagcccag ggacagctac ttccagcaat atatgcttaa gggtgagtat     1020

cagtactggt ttgacctgga tgcggaattc ggttccggag gctccggtga ctacaaagac     1080

catgacggtg attataaaga tcatgacatc gattacaagg atgacgatga caagcatcat     1140

caccatcacc at                                                         1152


<210>  56
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C strain-E2-KARD-DNA for BACULO EXPRESSION

<400>  56
atgatcgtgc aaggtgtggt atggctgtta ctagtaactg gggcacaagg ccggctagcc       60

tgcaaggaag attacaggta cgcaatatcg aaaaccgatg agatagggct acttgcagcc      120

agagatctca ccaccacctg gaaggaatac aaccacgatt tgcaactgaa tgacgggacc      180

gtcaaggcca gttgcgtggc aggttccttt aaagtcatag cacttaatgt ggtcagtagg      240

agatatttgg cgtcattgca taagaaggct ttacccactt ccgtgacatt cgagctcctg      300

ttcgacggga ccaacccatc aactgaggaa atgggagatg acttcaggtc cgggctgtgc      360

ccgtttgata cgagtcccgt tgttaaggga aagtacaata cgaccttgtt gaacggtagt      420

gctttctatc ttgtctgccc aatagggtgg acgggtgtca tagagtgcac agcagtgagc      480

ccaacaactc tgaggacaga agtggtaaag accttcagga gagacaagcc ctttccgcac      540

agaatggatt gtgtgaccac cacagtggaa aatgaagatt tattctattg taagttgggg      600

ggcaactgga catgtgtgaa aggcgagcca gtggtctaca cagggggggt agtaaaacaa      660

tgtagatggt gtggcttcga cttcgatggg cctgacggac tcccgcatta ccccataggt      720

aagtgcattt tggcaaatga gacaggttac agaatagtag attcaacgga ctgtaacaga      780

gatggcgttg taatcagcac agaggggagt catgagtgct tgatcggtaa cacgactgtc      840

aaggtgcatg catcagatga aagactgggc cctatgccat gcagacctaa agagattgtc      900

tctagtgctg gtcctgtaag gaaaacctcc tgtacattca actacacaaa aactttgaag      960

aacaggtact atgagcccag ggacagctac ttccagcaat atatgcttaa gggtgagtat     1020

cagtactggt ttgacctgga tgcggaattc ggttccggag gctccggtga ctacaaagac     1080

catgacggtg attataaaga tcatgacatc gattacaagg atgacgatga caagcatcat     1140

caccatcacc at                                                         1152


