
                                SEQUENCE LISTING

<110> Cantley, Lewis C.
      Paddock, Marcia Noreen
      Wang, Diana Grace      

<120> PIP4Ks Suppress Insulin Signaling and Enhance Immune
      Function Through a Catalytic-Independent Mechanism  

<130> 1676.146WO1

<150> US 62/831,895       
<151> 2019-04-10  

<150> US 62/847,411       
<151> 2019-05-14  

<160> 96

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1
Ile Asn Glu Leu Ser His Val Gln Ile Pro Val Met Leu Met Pro Asp
 1               5                  10                  15
Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val
            20                  25

<210> 2
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2
Ile Asn Glu Leu Ser Asn Val Pro Val Pro Val Met Leu Met Pro Asp
 1               5                  10                  15
Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val
            20                  25

<210> 3
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3
Ile Asn Glu Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro Asp
 1               5                  10                  15
Asp Phe Lys Ala Ser Ser Lys Ile Lys Val
            20                  25

<210> 4
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4
Ile Asn Glu Leu Ser Gln Val Pro Pro Pro Glu Ile Phe Leu Pro Asn
 1               5                  10                  15
Asn Phe Lys Ala Ser Ser Lys Ile Lys Val
            20                  25

<210> 5
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<221> SITE           
<222> 4
<223> Xaa = any amino acid

<400> 5
Val Met Leu Xaa Pro Asp Asp
 1               5

<210> 6
<211> 406
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Thr Pro Gly Asn Leu Gly Ser Ser Val Leu Ala Ser Lys Thr
 1               5                  10                  15
Lys Thr Lys Lys Lys His Phe Val Ala Gln Lys Val Lys Leu Phe Arg
            20                  25                  30
Ala Ser Asp Pro Leu Leu Ser Val Leu Met Trp Gly Val Asn His Ser
        35                  40                  45
Ile Asn Glu Leu Ser His Val Gln Ile Pro Val Met Leu Met Pro Asp
    50                  55                  60
Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp Asn His Leu Phe Asn
65                  70                  75                  80
Lys Glu Asn Met Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Met
                85                  90                  95
Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile Asp Asp Gln Asp Phe
            100                 105                 110
Gln Asn Ser Leu Thr Arg Ser Ala Pro Leu Pro Asn Asp Ser Gln Ala
        115                 120                 125
Arg Ser Gly Ala Arg Phe His Thr Ser Tyr Asp Lys Arg Tyr Ile Ile
    130                 135                 140
Lys Thr Ile Thr Ser Glu Asp Val Ala Glu Met His Asn Ile Leu Lys
145                 150                 155                 160
Lys Tyr His Gln Tyr Ile Val Glu Cys His Gly Ile Thr Leu Leu Pro
                165                 170                 175
Gln Phe Leu Gly Met Tyr Arg Leu Asn Val Asp Gly Val Glu Ile Tyr
            180                 185                 190
Val Ile Val Thr Arg Asn Val Phe Ser His Arg Leu Ser Val Tyr Arg
        195                 200                 205
Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg Glu Ala Ser Asp Lys
    210                 215                 220
Glu Lys Ala Lys Glu Leu Pro Thr Leu Lys Asp Asn Asp Phe Ile Asn
225                 230                 235                 240
Glu Gly Gln Lys Ile Tyr Ile Asp Asp Asn Asn Lys Lys Val Phe Leu
                245                 250                 255
Glu Lys Leu Lys Lys Asp Val Glu Phe Leu Ala Gln Leu Lys Leu Met
            260                 265                 270
Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val Glu Arg Ala Glu Gln
        275                 280                 285
Glu Glu Val Glu Cys Glu Glu Asn Asp Gly Glu Glu Glu Gly Glu Ser
    290                 295                 300
Asp Gly Thr His Pro Val Gly Thr Pro Pro Asp Ser Pro Gly Asn Thr
305                 310                 315                 320
Leu Asn Ser Ser Pro Pro Leu Ala Pro Gly Glu Phe Asp Pro Asn Ile
                325                 330                 335
Asp Val Tyr Gly Ile Lys Cys His Glu Asn Ser Pro Arg Lys Glu Val
            340                 345                 350
Tyr Phe Met Ala Ile Ile Asp Ile Leu Thr His Tyr Asp Ala Lys Lys
        355                 360                 365
Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu
    370                 375                 380
Ile Ser Thr Val Asn Pro Glu Gln Tyr Ser Lys Arg Phe Leu Asp Phe
385                 390                 395                 400
Ile Gly His Ile Leu Thr
                405

<210> 7
<211> 3820
<212> DNA
<213> Homo sapiens

<400> 7
agccgcgggc tgagcgcgga tccgcggcgg gcgcaggata cgggccgggg cgcgagccga      60
gcgcagtctg ccgggccgag cgggcggagc gagccgagtg gggctgagcg cgccggcggc     120
ggcgggcgga gcggagcgcg gcgcgccggg gccgccgccg gggggatgcg gctgcctccc     180
cgggccgggg tgtagagagg gcgggtcccc ggcctcggga gcacggcggt ggaggggaca     240
taggaggcgg ccatggcgac ccccggcaac ctagggtcct ctgtcctggc gagcaagacc     300
aagaccaaga agaagcactt cgtagcgcag aaagtgaagc tgtttcgggc cagcgacccg     360
ctgctcagcg tcctcatgtg gggggtaaac cactcgatca atgaactgag ccatgttcaa     420
atccctgtta tgttgatgcc agatgacttc aaagcctatt caaaaataaa ggtggacaat     480
caccttttta acaaagaaaa catgccgagc catttcaagt ttaaggaata ctgcccgatg     540
gtcttccgta acctgcggga gaggtttgga attgatgatc aagatttcca gaattccctg     600
accaggagcg cacccctccc caacgactcc caggcccgca gtggagctcg ttttcacact     660
tcctacgaca aaagatacat catcaagact attaccagtg aagacgtggc cgaaatgcac     720
aacatcctga agaaatacca ccagtacata gtggaatgtc atgggatcac ccttcttccc     780
cagttcttgg gcatgtaccg gcttaatgtt gatggagttg aaatatatgt gatagttaca     840
agaaatgtat tcagccaccg tttgtctgtg tataggaaat acgacttaaa gggctctaca     900
gtggctagag aagctagtga caaagaaaag gccaaagaac tgccaactct gaaagataat     960
gatttcatta atgagggcca aaagatttat attgatgaca acaacaagaa ggtcttcctg    1020
gaaaaactaa aaaaggatgt tgagtttctg gcccagctga agctcatgga ctacagtctg    1080
ctggtgggaa ttcatgatgt ggagagagcc gaacaggagg aagtggagtg tgaggagaac    1140
gatggggagg aggagggcga gagcgatggc acccacccgg tgggaacccc cccagatagc    1200
cccgggaata cactgaacag ctcaccaccc ctggctcccg gggagttcga tccgaacatc    1260
gacgtctatg gaattaagtg ccatgaaaac tcgcctagga aggaggtgta cttcatggca    1320
attattgaca tccttactca ttatgatgca aaaaagaaag ctgcccatgc tgcaaaaact    1380
gttaaacatg gcgctggcgc ggagatctcc accgtgaacc cagaacagta ttcaaagcgc    1440
tttttggact ttattggcca catcttgacg taacctcctg cgcagcctcg gacagacatg    1500
aacattggat ggacagaggt ggcttcggtg taggaaaaat gaaaaccaaa ctcagtgaag    1560
tactcatctt gcaggaagca aacctccttg tttacatctt caggccaaga tgactgattt    1620
gggggctact cgctttacag ctacctgatt ttcccagcat cgttctagct atttctgact    1680
ttgtgtatat gtgtgtgtgt gtgtgttggg ggggggtgag tgtgtgcgcg cgtgtgcatt    1740
ttaaaagtca taaattaatt aaaacagatc cacttcggtc agtatgtgtc ccaacaaaga    1800
ccctttgatt ccagctatgg ccgaatgaat gagtgagtga gtgagtgagt gaatgaacac    1860
acgtgtgggg gaggggagaa ggaagtgcat gatgtcaggc accgtgttgg catcacacaa    1920
caaactgtgg atcagttttt tttttttttt tttttttttg gagttgaaag atgtgagaca    1980
gtattcagaa taatgaagat aataatgatg attattataa taatgatgat gattccaagg    2040
aaaaaaccta cagcgaatgt tccatttcta ccccgcacgc agacactctc cctaacactg    2100
ataacctgag cccccagcac tggacggaag aatgctggcg tctccgtgtg tactggttca    2160
gggttctggc cccagccttg tcaggacccc ctggtgtcca gagcccccac ccctcccgca    2220
acaagcagct gatgccccag tgattctcta tacatttttc acctcggcca atatgtccag    2280
gaaaactgct tacttctctt ttcttgcctg gagccttcat tgttcaccct tacgttgcaa    2340
tataggaatt aatgctacaa aataaaagta aagcttacct gaaaagtgca tagtttgggg    2400
caatggtatc tacatctccc actgtgggaa aaccagcaaa gcatcaaaac tctcaattct    2460
cctgttacca aatgcagatc tgaattataa gatgtttatg tttgaccatt gtttcaacaa    2520
tgggattttg ttacgaatta tccctttaac tgaaaccctc agttttactg tttacattat    2580
taggaaaaca gggatatctt ttgaatctaa aaatttgatg tacagcatgt gatttttgaa    2640
gtttacatgt aaagtcacag tataggtgaa ataacgtttg tcatattttg agacgtatcc    2700
tgcagccatg tttttacgtg agtgttttag tcaaagtaca tggtagacag tctttcacaa    2760
taaaaggaaa aggatttttt tttcctccaa atgtacattt atcaacctaa tgattgattt    2820
ttttaaaaag agatttcgcc ccagtctggt ttatgaaagt tcattgccct aaactgtgct    2880
gattgttttt aatcaagtta taaatttcca acctagatca tgtatctacc aactctcctg    2940
cattttccaa aaggcattga gcttaaatat tagtcttgct tagagtaggt tatccactta    3000
catgctgcgc taaagccatg cctttgaaac tccttgttta aaacatgata tgatttttgt    3060
gggcagtttc agaaaagaaa acaaacaaac aaaaatcgac cctttaatta ttacttgcaa    3120
ctcaacagat ctccctgccg tactgccttt tccaggaact ttacttcagg gctgtccaga    3180
ttgcagctgt gccccgtgta tgtggatcta gttcacagag tctttggaag ccagcagtcg    3240
tgccctccgt atactgtcca ctcattttat gtagatttgg tatcctcagc agccagtgtt    3300
aacaccactg tcacgtagtg tacagattca tcttttatgt atttaaagta atccatacta    3360
tgatttggtt tttccctgca ccattaattc tggcatcaga tcagtttttg tgttgtgaag    3420
ttctactgtg gtttgaccca agaccacaac catgagaccc tgaagtaaag ataaggtaca    3480
catacattat ttgagtaact gtttccttgg gggccaatct gtgtatgctt ttagaagttt    3540
acagaatgct tttatttttg tctataacaa acagtctgtc atttatttct gttgataaac    3600
catttggaca gagtgaggac gtttgccctg ttatctccta gtgctaacaa tacactccag    3660
tcatgagccg ggctttacaa ataaagcact tttgatgact cacaagatga atcctttttt    3720
cctctgtccc aattgtgtgt ctctgttcca aacacatttt aaatactcgg tcctgacagt    3780
gtctttagct aatccttgaa gaaatgaaag tggaattgaa                          3820

<210> 8
<211> 416
<212> PRT
<213> Homo sapiens

<400> 8
Met Ser Ser Asn Cys Thr Ser Thr Thr Ala Val Ala Val Ala Pro Leu
 1               5                  10                  15
Ser Ala Ser Lys Thr Lys Thr Lys Lys Lys His Phe Val Cys Gln Lys
            20                  25                  30
Val Lys Leu Phe Arg Ala Ser Glu Pro Ile Leu Ser Val Leu Met Trp
        35                  40                  45
Gly Val Asn His Thr Ile Asn Glu Leu Ser Asn Val Pro Val Pro Val
    50                  55                  60
Met Leu Met Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp
65                  70                  75                  80
Asn His Leu Phe Asn Lys Glu Asn Leu Pro Ser Arg Phe Lys Phe Lys
                85                  90                  95
Glu Tyr Cys Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile
            100                 105                 110
Asp Asp Gln Asp Tyr Gln Asn Ser Val Thr Arg Ser Ala Pro Ile Asn
        115                 120                 125
Ser Asp Ser Gln Gly Arg Cys Gly Thr Arg Phe Leu Thr Thr Tyr Asp
    130                 135                 140
Arg Arg Phe Val Ile Lys Thr Val Ser Ser Glu Asp Val Ala Glu Met
145                 150                 155                 160
His Asn Ile Leu Lys Lys Tyr His Gln Phe Ile Val Glu Cys His Gly
                165                 170                 175
Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Thr Val Asp
            180                 185                 190
Gly Val Glu Thr Tyr Met Val Val Thr Arg Asn Val Phe Ser His Arg
        195                 200                 205
Leu Thr Val His Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg
    210                 215                 220
Glu Ala Ser Asp Lys Glu Lys Ala Lys Asp Leu Pro Thr Phe Lys Asp
225                 230                 235                 240
Asn Asp Phe Leu Asn Glu Gly Gln Lys Leu His Val Gly Glu Glu Ser
                245                 250                 255
Lys Lys Asn Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Ala
            260                 265                 270
Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val
        275                 280                 285
Asp Arg Ala Glu Gln Glu Glu Met Glu Val Glu Glu Arg Ala Glu Asp
    290                 295                 300
Glu Glu Cys Glu Asn Asp Gly Val Gly Gly Asn Leu Leu Cys Ser Tyr
305                 310                 315                 320
Gly Thr Pro Pro Asp Ser Pro Gly Asn Leu Leu Ser Phe Pro Arg Phe
                325                 330                 335
Phe Gly Pro Gly Glu Phe Asp Pro Ser Val Asp Val Tyr Ala Met Lys
            340                 345                 350
Ser His Glu Ser Ser Pro Lys Lys Glu Val Tyr Phe Met Ala Ile Ile
        355                 360                 365
Asp Ile Leu Thr Pro Tyr Asp Thr Lys Lys Lys Ala Ala His Ala Ala
    370                 375                 380
Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr Val Asn Pro
385                 390                 395                 400
Glu Gln Tyr Ser Lys Arg Phe Asn Glu Phe Met Ser Asn Ile Leu Thr
                405                 410                 415

<210> 9
<211> 5732
<212> DNA
<213> Homo sapiens

<400> 9
ttgcgggaaa gagccaaacc ctggcgttgg ggggcccggg cggggagccc ctcccgcggt      60
ccacagcgac gcctgcccag ccctcctccc cttccggctc cggcacgggg ccccgaggcg     120
ttcggaggcc aggcgggttt ctgtcaggcc cggggaggag gggcgggcgg ggcggccgct     180
gcctccccgg gacgggccgt accacgcgga cggggaggac ggggccaggg gactgcaggg     240
cggctgcacc gcccgggggc ggggtgcgga gcgggccggc gggctccccg gggcggggcg     300
ggagggcggg gcgtggggcg gacggaacca ccggggcggg gtgggaggta acgggacggg     360
cgcgaccatg gcgcggtgag ggagcggggg tggggatcgg tccgggggag gcctgaggcc     420
gctggcttgt gcgctgtctc cgccgccccc ctctttcgcc gccgccgccg ccgccccggg     480
catgtcgtcc aactgcacca gcaccacggc ggtggcggtg gcgccgctca gcgccagcaa     540
gaccaagacc aagaagaagc atttcgtgtg ccagaaagtg aagctattcc gggccagcga     600
gccgatcctc agcgtcctga tgtggggggt gaaccacacg atcaatgagc tgagcaatgt     660
tcctgttcct gtcatgctaa tgccagatga cttcaaagcc tacagcaaga tcaaggtgga     720
caatcatctc ttcaataagg agaacctgcc cagccgcttt aagtttaagg agtattgccc     780
catggtgttc cgaaaccttc gggagaggtt tggaattgat gatcaggatt accagaattc     840
agtgacgcgc agcgccccca tcaacagtga cagccagggt cggtgtggca cgcgtttcct     900
caccacctac gaccggcgct ttgtcatcaa gactgtgtcc agcgaggacg tggcggagat     960
gcacaacatc ttaaagaaat accaccagtt tatagtggag tgtcatggca acacgctttt    1020
gccacagttc ctgggcatgt accgcctgac cgtggatggt gtggaaacct acatggtggt    1080
taccaggaac gtgttcagcc atcggctcac tgtgcatcgc aagtatgacc tcaagggttc    1140
tacggttgcc agagaagcga gcgacaagga gaaggccaag gacttgccaa cattcaaaga    1200
caatgacttc ctcaatgaag ggcagaagct gcatgtggga gaggagagta aaaagaactt    1260
cctggagaaa ctgaagcggg acgttgagtt cttggcacag ctgaagatca tggactacag    1320
cctgctggtg ggcatccacg acgtggaccg ggcagagcag gaggagatgg aggtggagga    1380
gcgggcagag gacgaggagt gtgagaatga tggggtgggt ggcaacctac tctgctccta    1440
tggcacacct ccggacagcc ctggcaacct cctcagcttt cctcggttct ttggtcctgg    1500
ggaattcgac ccctctgttg acgtctatgc catgaaaagc catgaaagtt cccccaagaa    1560
ggaggtgtat ttcatggcca tcattgatat cctcacgcca tacgatacaa agaagaaagc    1620
tgcacatgct gccaaaacgg tgaaacacgg ggcaggggcc gagatctcga ctgtgaaccc    1680
tgagcagtac tccaaacgct tcaacgagtt tatgtccaac atcctgacgt agttctcttc    1740
taccttcagc cagagccaga gagctggata tggggtcggg gatcgggagt tagggagaag    1800
ggtgtatttg ggctagatgg gagggtggga gcagagtcgg gtttgggagg gctttagcaa    1860
tgagactgca gcctgtgaca ccgaaagaga ctttagctga agaggagggg gatgtgctgt    1920
gtgtgcacct gctcacagga tgtaacccca ccttctgctt acccttgatt ttttctcccc    1980
atttgacacc caggttaaaa aggggttccc tttttggtac cttgtaacct tttaagatac    2040
cttggggcta gagatgactt cgtgggttta tttgggtttt gtttctgaaa tttcattgct    2100
ccaggtttgc tatttataat catatttcat cagcctaccc accctcccca tctttgctga    2160
gctctcagtt cccttcaatt aaagagatac ccggtagacc cagcacaagg gtccttccag    2220
aaccaagtgc tatggatgcc agattggaga ggtcagacac ctcgccctgc tgcatttgct    2280
cttgtctgga ttaactttgt aatttatgga gtattgtgca caacttcctc cacctttccc    2340
ttggattcaa gtgaaaactg ttgcattatt cctccatcct gtctggaata caccaggtca    2400
acaccagaga tctcagatca gaatcagaga tctcagaggg gaataagttc atcctcatgg    2460
gatggtgagg ggcaggaaag cggctgggct cttggacacc tggttctcag agaaccctgt    2520
gatgatcacc caagccccag gctgtcttag cccctggagt tcagaagtcc tctctgtaaa    2580
gcctgcctcc cactaggtca agaggaacta gagtaccttt ggatttatca ggaccctcat    2640
gtttaaatgg ttatttccct ttgggaaaac ttcagaaact gatgtatcaa atgaggccct    2700
gtgccctcga tctatttcct tcttccttct gacctcctcc caggcactct tacttctagc    2760
cgaactctta gctctgggca gatctccaag cgcctggagt gctttttagc agagacacct    2820
cgttaagctc cgggatgacc ttgtaggaga tctgtctccc tgtgcctgga gagttacagc    2880
cagcaaggtg cccccatctt agagtgtggt gtccaaacgt gaggtggctt cctagttaca    2940
tgaggatgtg atccaggaaa tccagtttgg aggcttgatg tgggttttga cctggcctca    3000
gccttggggc tgtttttcct tgttgccccg ctctagactt ttagcagatc tgcagcccac    3060
aggctttttt ggaaggagtg gcttcctgca ggtgttccac ctgccttcgg agcctgccac    3120
ccaggccctc agaactgagc cacaggctgc tctggccagg agagaaacag ctctgttgtt    3180
ctgcattggg ggaggtacat tcctgcatct tctcaccccc tcaaccagga actggggatt    3240
tgggatgaga tatggtcaga cttgtagata accccaaaga tgtgaagatc gcttgtgaaa    3300
ccattttgaa tgaatagatt ggtttcctgt ggctccctcc aaacctggcc aagcccagct    3360
tccgaagcag gaaccagcac tgtctctgtg cctgactcac agcatatagg tcaggaaaga    3420
atggagacgg cattcttgga cttcactggg gctgctggat tggatgggaa accttctgga    3480
agaggcagat gggggtcaaa ccactgcctt ggccccagga aggggccata ggtaggtctg    3540
aacaactgcc gcaagaccac tacatgactt agggaacttg aaaccaactg gctcatggag    3600
aaaacaaatt tgacttggga aagggattat gtaggaataa tgtttggact tgatttcccc    3660
acgtcataat gaagaatgga agtttggatc tgctcctcgt caggcgcagc atctctgaag    3720
cttggaaagc tgtcttccag cagcctccgt ggcctcgggt tcctaccggc ttctctgcat    3780
ttggtctgct gatcatgttg ccataatgtg tatggaaagt gtaacacatt cttactggtt    3840
aaagacgact accaggtatc taacttgttt aacattgagt ttgtgtgtgt gtgtgtatgt    3900
ttgtgtgttt tgtatattgt ttacattttg agaggtagca ttctgtttca aatgcttttt    3960
gtttttctga cagtattgtt gactgggtca taacattttg agctgtggtt tggtggattt    4020
tcaatttttt tttttaaagg tcattcgctg tgctatcttc aaaaccttga gtttggcccc    4080
caatttttgg cattcaaatg tttaaaagct atttatcttg gtttatacaa gtttcctttc    4140
tcttcttttt gtcatggtat tctatttggt ctgcagtttg aatgtagaga aagtggactg    4200
atcccccaag cgttgtctgc ccccactctt tcctccttgg gtcccgccat tcttttactg    4260
ggcagtcgag ggcattggag gggaagtgac tgccctcagc ctcactccct ggggccatga    4320
agaaaagcta aacagtctca tggcatctca gaataatgtt gggtctccca agaagaaagg    4380
tgtaagaata acgacatggc tgattaggcg aggccaggat agggctaagg ccaggattcc    4440
tggctggcat ccagtcaccc cttctcccat ccttccccct cttcttccac aagtccgcag    4500
ccgagacact gtagtctccc agccacagtg atgagtgccc tggagactcc actgacctct    4560
agatgaaggc ccctggccct ggttcctgtt aattaacctc tgggtctttg agtcccccag    4620
cacaaacttc tttcctgtac cctgcggctt ggggtcacag ggcatgccgg gaagccacag    4680
ctgaggggcg cagactgaag cagtgctcca cctctccttc tttagctcag gggttgctgg    4740
tctgtggcag gcgccacgag tggcccctgt ggctgttctc agtggcagtc tcttaagttc    4800
ccaccacagg cagctcttta tcccctctcc ctacttgact ctttctcttg cctgtgcttt    4860
tggcctcaaa caggcctgct ggtagcgctc agggcgtgag gctacactcc tgccctgcct    4920
ttcctgtctt catggtctgc cagggcatac cttggggagg tggaccaaag acccaggact    4980
ttttgcagta gccagtccta ccccccagtt gtctttttac caattcaggg tgggagagaa    5040
aactgcagca ccccagcatg tgagttactc aggtgttggg ggctagaagg gacagtgcgt    5100
ttaaacaaca ctcagagctc tggccttaaa cctgtggccc cccaagtcta ggagcctcat    5160
ctcttcctgg cagtcatgcg ggcaggaggt cctgaaaggg aaaacccatt cagacaactg    5220
ttccccaatc taccagccat ctgcaggggt cagtgaccgt ggccctctcc ctcctctaga    5280
atgtgccact tatgaagagt gccccatggg gaaaaggaga ctcagctgtc ccttggcagc    5340
ttgtgccagt atcccagggc agaagtttcc acaggagcct cttgcccttg cgcagagcca    5400
ctgtgagagg cggtgggagc caacaccctt gggggagggg gcagtactgc tcggcacatc    5460
ccagcatcag gtcagatcat tgaaattaaa aaatgtgaat taagttcata tccacctttt    5520
ggggaagcag gacaaaccac caccccacca agtgtgtgac ttctccatat cccactgcag    5580
tttccatttt ttaaatggga attttcaatc ccctgtgctt gtctaacgtc tgctttaaaa    5640
agtttgagac cctgttactg tttgaaaatg catgcatgtt acgatgaatc tccaacctga    5700
ggaaaaaaat aaaactcaaa aagctttgtg ta                                  5732



<210> 10
<211> 421
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala
 1               5                  10                  15
Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His
            20                  25                  30
Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val
        35                  40                  45
Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln
    50                  55                  60
Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser
65                  70                  75                  80
Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser
                85                  90                  95
His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg
            100                 105                 110
Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg
        115                 120                 125
Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser
    130                 135                 140
Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala
145                 150                 155                 160
Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys
                165                 170                 175
His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser
            180                 185                 190
Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser
        195                 200                 205
His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val
    210                 215                 220
Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu
225                 230                 235                 240
Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu
                245                 250                 255
Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe
            260                 265                 270
Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His
        275                 280                 285
Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu
    290                 295                 300
Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala
305                 310                 315                 320
Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile
                325                 330                 335
His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp
            340                 345                 350
Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr
        355                 360                 365
Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys
    370                 375                 380
Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile
385                 390                 395                 400
Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile
                405                 410                 415
Thr Asn Ile Phe Ala
            420

<210> 11
<211> 3176
<212> DNA
<213> Homo sapiens

<400> 11
ggtcacgtga cagcagcgca ggtgagcgcc gcttccgggg tcgggcgcct ggatagctgc      60
cggctccggc ttccacttgg tcggttgcgc gggagactat ggcgtcctcc tcggtcccac     120
cagccacggt atcggcggcg acagcaggcc ccggcccagg tttcggcttc gcctccaaga     180
ccaagaagaa gcatttcgtg cagcagaagg tgaaggtgtt ccgggcggcc gacccgctgg     240
tgggtgtgtt cctgtggggc gtagcccact cgatcaatga gctcagccag gtgcctcccc     300
cggtgatgct gctgccagat gactttaagg ccagctccaa gatcaaggtc aacaatcacc     360
ttttccacag ggaaaatctg cccagtcatt tcaagttcaa ggagtattgt ccccaggtct     420
tcaggaacct ccgtgatcga tttggcattg atgaccaaga ttacttggtg tcccttaccc     480
gaaacccccc cagcgaaagt gaaggcagtg atggtcgctt ccttatctcc tacgatcgga     540
ctctggtcat caaagaagta tccagtgagg acattgctga catgcatagc aacctctcca     600
actatcacca gtacattgtg aagtgccatg gcaacacgct tctgccccag ttcctgggga     660
tgtaccgagt cagtgtggac aacgaagaca gctacatgct tgtgatgcgc aatatgttta     720
gccaccgtct tcctgtgcac aggaagtatg acctcaaggg ttccctagtg tcccgggaag     780
ccagcgataa ggaaaaggtt aaagaattgc ccacccttaa ggatatggac tttctcaaca     840
agaaccagaa agtatatatt ggtgaagagg agaagaaaat atttctggag aagctgaaga     900
gagatgtgga gtttctagtg cagctgaaga tcatggacta cagccttctg ctaggcatcc     960
acgacatcat tcggggctct gaaccagagg aggaagcgcc cgtgcgggag gatgagtcag    1020
aggtggatgg ggactgcagc ctgactggac ctcctgctct ggtgggctcc tatggcacct    1080
ccccagaggg tatcggaggc tacatccatt cccatcggcc cctgggccca ggagagtttg    1140
agtccttcat tgatgtctat gccatccgga gtgctgaagg agccccccag aaggaggtct    1200
acttcatggg cctcattgat atccttacac agtatgatgc taagaagaaa gcagctcatg    1260
cagccaaaac tgtcaagcat ggggctgggg cagagatctc tactgtccat ccggagcagt    1320
atgctaagcg attcctggat tttattacca acatctttgc ctaagagact gcctggttct    1380
ctctgatgtt caaggtggtg gggttctgag acacttgggg gaattgtggg gatattctag    1440
ccaccagttc tcttcttcct ttgctaaatt caggctgcag gctccttcca tccagataac    1500
tccatcctgt cgagtaggct ctttctgacc ctcagaaata cattgtcctt tttcctcttt    1560
gcccattttt cttccctctc ttcctcccca tgagaagtct gcttgtagta ttagaatgtt    1620
attgttgact ctctcccaag tgccttgatc tttgtaatat ctcctgttgt ttctatgata    1680
taggagctag gggaaggggg ttgtttgcct tcttcaggac ctgactggac agatggacct    1740
ggctcaagca actactctgg atgcactttg ctgtgtggga tgaactaaaa gtgtctgaat    1800
tttgctgata actttataaa actcactatg gcatgcttcc ctcctggtgg gccctaggat    1860
ggatgacact caagatacta cagatgtggg tgcaggcatg cacacacacg atggaatatg    1920
gccattccta cacaggtggg gtagagagtg ggtcagcagc ctggcacctc acagaggtgg    1980
gacctaagag gactcatgat tatgcagaga attggattgg gtctctgtca tagattgagt    2040
aatctcttcc cttacctcaa ttccatctcc acccatctct acatctgggc acagcaaccc    2100
agagatggcc aaaagcattc aagcctgggg gaagatgttt gactattgct gctcttcacc    2160
agaacctcac acctctcctg ggactggaac ccttcagtgg gtgtgtggcc agttttggag    2220
gctggaatga tgggccaggg tgtaggattc attctccatg taaagtttcc tttcatcctg    2280
cctagccatc cccaaggttt atttccagaa gaaaggaata tctctacttg gatcaattct    2340
ggtcatttca agaggatgga ggcctcaagt gtgggaactt cccctactcc ctggatgtgt    2400
gtacctagca cacttccttc tcccacccct ttttccagtt ggatttgttt ttctgttctc    2460
ttctgtcctg tcttatactg caactgtgtc tcctagggga cagatggcct tctttgtcat    2520
cttcactctc cacccccaga gaggagtcag agccataact caatcactca gcccctccaa    2580
agatagttga tgtgtgataa tctcataatg ttgagaaccc tgatgagata cattgtcttc    2640
ctctccctac aatgcctctg gggccaaggc acccattctt cttgctatcc tccatccccc    2700
ttgaggcttc cacttttttt ttttttagac ataaagctgg gcatcagcaa ctggcctgtg    2760
gtgatgcaaa gctgctttgc tctgtatctg gctggactga tctgtctcac aagaagccat    2820
gaggccatag ggagaagctc cctctcccct tcatcttctg ctccaaaggt ggtagcaaga    2880
ggagtaccca gttaggggtt ggagccccca tataacatct tcctgtcaga agactgatgg    2940
atctttttca ttccaaccat ctccctttcc cccgatgaat gcaataaaac tctgtgacac    3000
cagcaaccat tgctctttag aaatgggttt tctgatcata tggctgatgt gttatgggca    3060
gtatggatgt cttcatttgt tgcttctgtt tttcatcttt tttgttttat taataaaaat    3120
ttatgtattt gctcctgtta ctataataat acagggaata aattattcaa tccaaa        3176

<210> 12
<211> 491
<212> PRT
<213> Homo sapiens

<400> 12
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45
Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys
    50                  55                  60
Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp
65                  70                  75                  80
Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His
                85                  90                  95
Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln
            100                 105                 110
Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His
        115                 120                 125
Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu
    130                 135                 140
Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser
145                 150                 155                 160
Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser
                165                 170                 175
Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser
            180                 185                 190
Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu
        195                 200                 205
Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu
    210                 215                 220
Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser
225                 230                 235                 240
Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser
                245                 250                 255
Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp
            260                 265                 270
Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr
        275                 280                 285
Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys
    290                 295                 300
Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn
305                 310                 315                 320
Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys
                325                 330                 335
Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln
            340                 345                 350
Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn
        355                 360                 365
Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln
    370                 375                 380
Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser
385                 390                 395                 400
Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg
                405                 410                 415
Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu
            420                 425                 430
Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly
        435                 440                 445
Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys
    450                 455                 460
Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln
465                 470                 475                 480
Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro
                485                 490

<210> 13
<211> 64
<212> PRT
<213> Homo sapiens

<400> 13
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45
Thr Met Lys Glu Phe Ala Thr Lys His Arg Ala Lys Asn Ile Pro Val
    50                  55                  60

<210> 14
<211> 60
<212> PRT
<213> Homo sapiens

<400> 14
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45
Thr Met Lys Glu Asn His Arg Thr Gln Val His Leu
    50                  55                  60

<210> 15
<211> 73
<212> PRT
<213> Homo sapiens

<400> 15
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45
Thr Met Lys Glu Glu Asn Ile Tyr His Asp Leu Gln Glu Leu Gly Ser
    50                  55                  60
Ser Gln Ser Ala Gly Arg Lys Phe Arg
65                  70

<210> 16
<211> 497
<212> PRT
<213> Homo sapiens

<400> 16
Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp
 1               5                  10                  15
Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
            20                  25                  30
Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala
        35                  40                  45
Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe
    50                  55                  60
Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val
65                  70                  75                  80
Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe
                85                  90                  95
Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn
            100                 105                 110
Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala
        115                 120                 125
Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly
    130                 135                 140
Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met
145                 150                 155                 160
Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr
                165                 170                 175
Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr
            180                 185                 190
Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys
        195                 200                 205
Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe
    210                 215                 220
Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu
225                 230                 235                 240
Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu
                245                 250                 255
Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe
            260                 265                 270
Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
        275                 280                 285
Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly
    290                 295                 300
Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His
305                 310                 315                 320
Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln
                325                 330                 335
Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu
            340                 345                 350
Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp
        355                 360                 365
Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe
    370                 375                 380
Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser
385                 390                 395                 400
Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn
                405                 410                 415
Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln
            420                 425                 430
Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys
        435                 440                 445
Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro
    450                 455                 460
Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys
465                 470                 475                 480
Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met
                485                 490                 495
Ser


<210> 17
<211> 618
<212> PRT
<213> Homo sapiens

<400> 17
Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln
 1               5                  10                  15
Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr
            20                  25                  30
Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr
        35                  40                  45
Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu
    50                  55                  60
Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys
65                  70                  75                  80
Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly
                85                  90                  95
Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe
            100                 105                 110
Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr
        115                 120                 125
Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu
    130                 135                 140
His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro
145                 150                 155                 160
Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro
                165                 170                 175
Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His
            180                 185                 190
Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly
        195                 200                 205
Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly
    210                 215                 220
Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His
225                 230                 235                 240
Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr
                245                 250                 255
Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg
            260                 265                 270
Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu
        275                 280                 285
Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val
    290                 295                 300
Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp
305                 310                 315                 320
Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu
                325                 330                 335
Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr
            340                 345                 350
Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu
        355                 360                 365
Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser
    370                 375                 380
Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu
385                 390                 395                 400
Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys
                405                 410                 415
Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser
            420                 425                 430
Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys
        435                 440                 445
Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn
    450                 455                 460
Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp
465                 470                 475                 480
Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile
                485                 490                 495
Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr
            500                 505                 510
Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu
        515                 520                 525
Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn
    530                 535                 540
Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu
545                 550                 555                 560
Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp
                565                 570                 575
Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys
            580                 585                 590
Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile
        595                 600                 605
Ile Lys Gly Thr Val Arg Thr Phe Leu Ser
    610                 615

<210> 18
<211> 298
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro
 1               5                  10                  15
Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro
            20                  25                  30
Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp
        35                  40                  45
Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu
    50                  55                  60
Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala
65                  70                  75                  80
Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp
                85                  90                  95
Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly
            100                 105                 110
Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr
        115                 120                 125
Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His
    130                 135                 140
Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg
145                 150                 155                 160
Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser
                165                 170                 175
Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser
            180                 185                 190
Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val
        195                 200                 205
Gln Ser Glu Ser Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala
    210                 215                 220
Gln Arg Ala Trp Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu
225                 230                 235                 240
Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu
                245                 250                 255
Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys
            260                 265                 270
Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro
        275                 280                 285
Val Arg Ser Arg Val Arg Thr Phe Leu Ser
    290                 295

<210> 19
<211> 213
<212> PRT
<213> Homo sapiens

<400> 19
Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu
 1               5                  10                  15
Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu
            20                  25                  30
Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu
        35                  40                  45
Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg
    50                  55                  60
Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser
65                  70                  75                  80
Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln
                85                  90                  95
Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr
            100                 105                 110
Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu
        115                 120                 125
Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly
    130                 135                 140
Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu
145                 150                 155                 160
Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg
                165                 170                 175
Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro
            180                 185                 190
Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His
        195                 200                 205
Gln Arg Met Gly Asp
    210

<210> 20
<211> 172
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu
 1               5                  10                  15
Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu
            20                  25                  30
Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu
        35                  40                  45
Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg
    50                  55                  60
Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser
65                  70                  75                  80
Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln
                85                  90                  95
Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr
            100                 105                 110
Arg Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg Ser Leu
        115                 120                 125
Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr
    130                 135                 140
Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu Arg Leu
145                 150                 155                 160
Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp
                165                 170

<210> 21
<211> 193
<212> PRT
<213> Homo sapiens

<400> 21
Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu
 1               5                  10                  15
Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu
            20                  25                  30
Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu
        35                  40                  45
Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg
    50                  55                  60
Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser
65                  70                  75                  80
Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln
                85                  90                  95
Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr
            100                 105                 110
Arg Val Leu Met Thr Pro Val Gly Gln Phe Cys Val Val Pro Ala Leu
        115                 120                 125
Val Glu Asn Thr Phe Leu Leu Gly Arg Leu Thr Asp Ala Lys Thr Gly
    130                 135                 140
Thr Ser Gln Gly His Val Gly Ala Gly Arg Ala Asp Arg Val Trp Arg
145                 150                 155                 160
Gly Lys Leu Thr Tyr Leu Pro Ala Gly Arg Trp Arg Gly Cys Gly Cys
                165                 170                 175
Val Val Ser Val Lys Glu His Phe Pro Glu Lys Glu Glu Ser Arg Met
            180                 185                 190
Glu


<210> 22
<211> 442
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn
 1               5                  10                  15
His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu
            20                  25                  30
Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn
        35                  40                  45
Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met
    50                  55                  60
Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val
65                  70                  75                  80
Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr
                85                  90                  95
Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn
            100                 105                 110
Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val
        115                 120                 125
Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr
    130                 135                 140
Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile
145                 150                 155                 160
Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly
                165                 170                 175
Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser
            180                 185                 190
Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe
        195                 200                 205
Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp
    210                 215                 220
Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp
225                 230                 235                 240
Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg
                245                 250                 255
Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser
            260                 265                 270
Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu
        275                 280                 285
Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala
    290                 295                 300
Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser
305                 310                 315                 320
Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu
                325                 330                 335
Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro
            340                 345                 350
His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu
        355                 360                 365
Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr
    370                 375                 380
Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp
385                 390                 395                 400
Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly
                405                 410                 415
Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu
            420                 425                 430
Ile Ser Pro Asp Lys Val Ile Leu Cys Leu
        435                 440

<210> 23
<211> 441
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn
 1               5                  10                  15
His Leu Pro Leu Leu Pro Glu Ser Glu Glu Glu Asp Glu Met Glu Val
            20                  25                  30
Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe
        35                  40                  45
Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu
    50                  55                  60
Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val Ile
65                  70                  75                  80
Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr Leu
                85                  90                  95
Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn Leu
            100                 105                 110
Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln
        115                 120                 125
Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg
    130                 135                 140
Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile Gly
145                 150                 155                 160
Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile
                165                 170                 175
Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr
            180                 185                 190
Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro
        195                 200                 205
Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln
    210                 215                 220
Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro
225                 230                 235                 240
Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile
                245                 250                 255
Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu
            260                 265                 270
Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro
        275                 280                 285
Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile
    290                 295                 300
Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu
305                 310                 315                 320
Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile
                325                 330                 335
Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His
            340                 345                 350
Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn
        355                 360                 365
Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala
    370                 375                 380
Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys
385                 390                 395                 400
Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu
                405                 410                 415
Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile
            420                 425                 430
Ser Pro Asp Lys Val Ile Leu Cys Leu
        435                 440

<210> 24
<211> 379
<212> PRT
<213> Homo sapiens

<400> 24
Met Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln
 1               5                  10                  15
Val Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln
            20                  25                  30
Thr Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg
        35                  40                  45
Asn Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn
    50                  55                  60
Val Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala
65                  70                  75                  80
Tyr Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala
                85                  90                  95
Ile Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp
            100                 105                 110
Gly Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro
        115                 120                 125
Ser Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile
    130                 135                 140
Phe Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp
145                 150                 155                 160
Trp Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser
                165                 170                 175
Trp Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp
            180                 185                 190
Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp
        195                 200                 205
Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys
    210                 215                 220
Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser
225                 230                 235                 240
Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr
                245                 250                 255
Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn
            260                 265                 270
Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn
        275                 280                 285
Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn
    290                 295                 300
Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly
305                 310                 315                 320
Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly
                325                 330                 335
Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp
            340                 345                 350
Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp
        355                 360                 365
Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu
    370                 375

<210> 25
<211> 398
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn
 1               5                  10                  15
His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu
            20                  25                  30
Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn
        35                  40                  45
Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met
    50                  55                  60
Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val
65                  70                  75                  80
Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr
                85                  90                  95
Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn
            100                 105                 110
Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val
        115                 120                 125
Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr
    130                 135                 140
Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile
145                 150                 155                 160
Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly
                165                 170                 175
Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser
            180                 185                 190
Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe
        195                 200                 205
Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp
    210                 215                 220
Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp
225                 230                 235                 240
Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg
                245                 250                 255
Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser
            260                 265                 270
Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu
        275                 280                 285
Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala
    290                 295                 300
Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser
305                 310                 315                 320
Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu
                325                 330                 335
Ile Phe Arg Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser
            340                 345                 350
His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln
        355                 360                 365
Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp
    370                 375                 380
Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu
385                 390                 395

<210> 26
<211> 475
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys
 1               5                  10                  15
Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly
            20                  25                  30
His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly
        35                  40                  45
Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg
    50                  55                  60
Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser
65                  70                  75                  80
Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly
                85                  90                  95
Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp
            100                 105                 110
Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu
        115                 120                 125
Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly
    130                 135                 140
Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile
145                 150                 155                 160
Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser
                165                 170                 175
Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu
            180                 185                 190
Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu
        195                 200                 205
Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala
    210                 215                 220
Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala
225                 230                 235                 240
Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser
                245                 250                 255
Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val
            260                 265                 270
Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His
        275                 280                 285
Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu
    290                 295                 300
Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly
305                 310                 315                 320
Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His
                325                 330                 335
Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu
            340                 345                 350
Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His
        355                 360                 365
Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn
    370                 375                 380
Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu
385                 390                 395                 400
Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly
                405                 410                 415
Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser
            420                 425                 430
Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro
        435                 440                 445
Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro
    450                 455                 460
Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr
465                 470                 475

<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 27
tgtttgaatg aggcttcagt ac                                               22

<210> 28
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 28
aggcgcgaag actcaattga aggctcgaga aggtatattg ctg                        43

<210> 29
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 29
cacttttttc aattgacacg tacgcgtatt ctaccgggta                            40

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 30
agagtggatg ggcaagaagc                                                  20

<210> 31
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 31
aagatggagt cattgctgtt ca                                               22

<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 32
gattgactct ccctcaccac t                                                21

<210> 33
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 33
ctgtgtacaa gagcagaggt tc                                               22

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 34
tgcttgagct caggacagtg                                                  20

<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 35
actaagacca agatggggcc                                                  20

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 36
gctggtgtgg gcagattgct                                                  20

<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 37
cactgctaca gcctcacact g                                                21

<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 38
gattgcctgc attcgctctg                                                  20

<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 39
atgctgctgt ttggatgggt                                                  20

<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 40
gttctcatgg catctccaag g                                                21

<210> 41
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 41
gactgttgtg agcatgaagt tc                                               22

<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 42
gagggcctat ttcccatgat t                                                21

<210> 43
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 43
ccagctgaag ctcatgaact acagtctgct ggtgggaatt cat                        43

<210> 44
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 44
atgaattccc accagcagac tgtagttcat gagcttcagc tgg                        43

<210> 45
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 45
taggaaggag gtgtacttca tggcaattat taacatcctt actcatt                    47

<210> 46
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 46
aatgagtaag gatgttaata attgccatga agtacacctc cttccta                    47

<210> 47
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 47
acagctgaag atcatgaact acagcctgct ggtgggcatc cac                        43

<210> 48
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 48
gtggatgccc accagcaggc tgtagttcat gatcttcagc tgt                        43

<210> 49
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 49
gtatttcatg gccatcatta atatcctcac gccatacgat a                          41

<210> 50
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 50
tatcgtatgg cgtgaggata ttaatgatgg ccatgaaata c                          41

<210> 51
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 51
agtgcagctg aagatcatga actacagcct tctgctaggc atcc                       44

<210> 52
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 52
ggatgcctag cagaaggctg tagttcatga tcttcagctg cact                       44

<210> 53
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 53
ccagaaggag gtctacttca tgggcctcat tgatatcctt acacag                     46

<210> 54
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 54
ctgtgtaagg atatcaatga ggcccatgaa gtagacctcc ttctgg                     46

<210> 55
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 55
gcatgtaccg gcttaatgtt gatggtgtag agatttacgt cattgtaact aggaacgtat      60
tcagccaccg tttgtctgtg tatagg                                           86

<210> 56
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 56
cctatacaca gacaaacggt ggctgaatac gttcctagtt acaatgacgt aaatctctac      60
accatcaaca ttaagccggt acatgc                                           86

<210> 57
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 57
cttccgtaac ctgcgggaaa gattcggtat agacgaccaa gatttccaga attccctg        58

<210> 58
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 58
cagggaattc tggaaatctt ggtcgtctat accgaatctt tcccgcaggt tacggaag        58

<210> 59
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 59
cattgatatc ctcacccctt atgacactaa aaaaaaagct gcacatgctg ccaaaac         57

<210> 60
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 60
gttttggcag catgtgcagc ttttttttta gtgtcataag gggtgaggat atcaatg         57

<210> 61
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 61
ccagcgagga cgtggcggag atgcataata tattgaaaaa gtaccaccag tttatag         57

<210> 62
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 62
ctataaactg gtggtacttt ttcaatatat tatgcatctc cgccacgtcc tcgctgg         57

<210> 63
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 63
ggttatgctg ctgccgaaca atttcaaggc gagcag                                36

<210> 64
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 64
ctgctcgcct tgaaattgtt cggcagcagc ataacc                                36

<210> 65
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 65
atttgaagtg gctcggcagg tcttcctcgt gaaacaggtg gttgttaacc                 50

<210> 66
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 66
ggttaacaac cacctgtttc acgaggaaga cctgccgagc cacttcaaat                 50

<210> 67
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 67
agccaggtgc cgccgccgga gatattcctg ccgaacaatt tcaagg                     46

<210> 68
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 68
ccttgaaatt gttcggcagg aatatctccg gcggcggcac ctggct                     46

<210> 69
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 69
accttggggc agtagtgag                                                   19

<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 70
tcccgctgtt tctgaatacc a                                                21

<210> 71
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 71
gcatgacacc gctaaagaaa ac                                               22

<210> 72
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 72
cacaacgtga tgattatgtg ggt                                              23

<210> 73
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 73
attcagggcg agtacatgat cc                                               22

<210> 74
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 74
cgacaccttg agcgtgtag                                                   19

<210> 75
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 75
cacgagaaat gcaacacgtt ac                                               22

<210> 76
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 76
gggtgccact aacacatctg tat                                              23

<210> 77
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 77
atagcacagc ctggatagca acgtac                                           26

<210> 78
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 78
caccttctac aatgagctgc gtgtg                                            25

<210> 79
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 79
tagataagca ttataattcc ta                                               22

<210> 80
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 80
tatcacatat atttcaactc ca                                               22

<210> 81
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 81
tacatttctt gtaactatca ca                                               22

<210> 82
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 82
tttcttcttt gtatcgtatg gc                                               22

<210> 83
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 83
tatttcttta agatgttgtg ca                                               22

<210> 84
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 84
ttgaacatca gagagaacca gg                                               22

<210> 85
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 85
ttctaaagag caatggttgc tg                                               22

<210> 86
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 86
tattattata gtaacaggag ca                                               22

<210> 87
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 87
ttgatcatca attccaaacc tc                                               22

<210> 88
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 88
tcatctggca tcaacataac agg                                              23

<210> 89
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 89
gaataggctt tgaagtcatc tgg                                              23

<210> 90
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 90
tcatctggca ttagcatgac agg                                              23

<210> 91
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 91
gtccaccttg atcttgctgt agg                                              23

<210> 92
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 92
atctggcagc agcatcaccg ggg                                              23

<210> 93
<211> 7
<212> PRT
<213> Homo sapiens

<400> 93
Val Met Leu Leu Pro Asp Asp
 1               5

<210> 94
<211> 7
<212> PRT
<213> Homo sapiens

<400> 94
Phe His Arg Glu Asn Leu Pro
 1               5

<210> 95
<211> 7
<212> PRT
<213> Homo sapiens

<400> 95
Glu Ile Phe Leu Pro Asn Asn
 1               5

<210> 96
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic polypeptide

<221> SITE           
<222> 5
<223> Xaa = any amino acid

<400> 96
Val Met Leu Xaa Pro Asp Asp
 1               5
