                         SEQUENCE LISTING

<110>  University of Kentucky Research Foundation
       Zhan, Chang-Guo
 
<120>  MODIFIED PROSTATE APOPTOSIS RESPONSE-4 (PAR-4) POLYPEPTIDE, AND 
       METHODS OF PRODUCTION AND USE

<130>  13177N/2354US

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  332
<212>  PRT
<213>  Rattus rattus

<400>  1

Met Ala Thr Gly Gly Tyr Arg Ser Ser Gly Ser Thr Thr Asp Phe Leu 
1               5                   10                  15      


Glu Glu Trp Lys Ala Lys Arg Glu Lys Met Arg Ala Lys Gln Asn Pro 
            20                  25                  30          


Val Gly Pro Gly Ser Ser Gly Gly Asp Pro Ala Ala Lys Ser Pro Ala 
        35                  40                  45              


Gly Pro Leu Ala Gln Thr Thr Ala Ala Gly Thr Ser Glu Leu Asn His 
    50                  55                  60                  


Gly Pro Ala Gly Ala Ala Ala Pro Ala Ala Pro Gly Pro Gly Ala Leu 
65                  70                  75                  80  


Asn Cys Ala His Gly Ser Ser Ala Leu Pro Arg Gly Ala Pro Gly Ser 
                85                  90                  95      


Arg Arg Pro Glu Asp Glu Cys Pro Ile Ala Ala Gly Ala Ala Gly Ala 
            100                 105                 110         


Pro Ala Ser Arg Gly Asp Glu Glu Glu Pro Asp Ser Ala Pro Glu Lys 
        115                 120                 125             


Gly Arg Ser Ser Gly Pro Ser Ala Arg Lys Gly Lys Gly Gln Ile Glu 
    130                 135                 140                 


Lys Arg Lys Leu Arg Glu Lys Arg Arg Ser Thr Gly Val Val Asn Ile 
145                 150                 155                 160 


Pro Ala Ala Glu Cys Leu Asp Glu Tyr Glu Asp Asp Glu Ala Gly Gln 
                165                 170                 175     


Lys Glu Arg Lys Arg Glu Asp Ala Ile Thr Gln Gln Asn Thr Ile Gln 
            180                 185                 190         


Asn Glu Ala Ala Ser Leu Pro Asp Pro Gly Thr Ser Tyr Leu Pro Gln 
        195                 200                 205             


Asp Pro Ser Arg Thr Val Pro Gly Arg Tyr Lys Ser Thr Ile Ser Ala 
    210                 215                 220                 


Pro Glu Glu Glu Ile Leu Asn Arg Tyr Pro Arg Thr Asp Arg Ser Gly 
225                 230                 235                 240 


Phe Ser Arg His Asn Arg Asp Thr Ser Ala Pro Ala Asn Phe Ala Ser 
                245                 250                 255     


Ser Ser Thr Leu Glu Lys Arg Ile Glu Asp Leu Glu Lys Glu Val Leu 
            260                 265                 270         


Arg Glu Arg Gln Glu Asn Leu Arg Leu Thr Arg Leu Met Gln Asp Lys 
        275                 280                 285             


Glu Glu Met Ile Gly Lys Leu Lys Glu Glu Ile Asp Leu Leu Asn Arg 
    290                 295                 300                 


Asp Leu Asp Asp Met Glu Asp Glu Asn Glu Gln Leu Lys Gln Glu Asn 
305                 310                 315                 320 


Lys Thr Leu Leu Lys Val Val Gly Gln Leu Thr Arg 
                325                 330         


<210>  2
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Thr Gly Gly Tyr Arg Thr Ser Ser Gly Leu Gly Gly Ser Thr Thr 
1               5                   10                  15      


Asp Phe Leu Glu Glu Trp Lys Ala Lys Arg Glu Lys Met Arg Ala Lys 
            20                  25                  30          


Gln Asn Pro Pro Gly Pro Ala Pro Pro Gly Gly Gly Ser Ser Asp Ala 
        35                  40                  45              


Ala Gly Lys Pro Pro Ala Gly Ala Leu Gly Thr Pro Ala Ala Ala Ala 
    50                  55                  60                  


Ala Asn Glu Leu Asn Asn Asn Leu Pro Gly Gly Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Ala Val Pro Gly Pro Gly Gly Val Asn Cys Ala Val Gly Ser Ala Met 
                85                  90                  95      


Leu Thr Arg Ala Ala Pro Gly Pro Arg Arg Ser Glu Asp Glu Pro Pro 
            100                 105                 110         


Ala Ala Ser Ala Ser Ala Ala Pro Pro Pro Gln Arg Asp Glu Glu Glu 
        115                 120                 125             


Pro Asp Gly Val Pro Glu Lys Gly Lys Ser Ser Gly Pro Ser Ala Arg 
    130                 135                 140                 


Lys Gly Lys Gly Gln Ile Glu Lys Arg Lys Leu Arg Glu Lys Arg Arg 
145                 150                 155                 160 


Ser Thr Gly Val Val Asn Ile Pro Ala Ala Glu Cys Leu Asp Glu Tyr 
                165                 170                 175     


Glu Asp Asp Glu Ala Gly Gln Lys Glu Arg Lys Arg Glu Asp Ala Ile 
            180                 185                 190         


Thr Gln Gln Asn Thr Ile Gln Asn Glu Ala Val Asn Leu Leu Asp Pro 
        195                 200                 205             


Gly Ser Ser Tyr Leu Leu Gln Glu Pro Pro Arg Thr Val Ser Gly Arg 
    210                 215                 220                 


Tyr Lys Ser Thr Thr Ser Val Ser Glu Glu Asp Val Ser Ser Arg Tyr 
225                 230                 235                 240 


Ser Arg Thr Asp Arg Ser Gly Phe Pro Arg Tyr Asn Arg Asp Ala Asn 
                245                 250                 255     


Val Ser Gly Thr Leu Val Ser Ser Ser Thr Leu Glu Lys Lys Ile Glu 
            260                 265                 270         


Asp Leu Glu Lys Glu Val Val Arg Glu Arg Gln Glu Asn Leu Arg Leu 
        275                 280                 285             


Val Arg Leu Met Gln Asp Lys Glu Glu Met Ile Gly Lys Leu Lys Glu 
    290                 295                 300                 


Glu Ile Asp Leu Leu Asn Arg Asp Leu Asp Asp Ile Glu Asp Glu Asn 
305                 310                 315                 320 


Glu Gln Leu Lys Gln Glu Asn Lys Thr Leu Leu Lys Val Val Gly Gln 
                325                 330                 335     


Leu Thr Arg 
            


<210>  3
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Glu Pro Lys Cys Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 


<210>  4
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Polypeptide Sequence, Synthetic

<400>  4

Met Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 


<210>  5
<211>  1701
<212>  DNA
<213>  Artificial

<220>
<223>  Modified Nucleotide Sequence, Synthetic

<400>  5
atgcaggagc ctaagtcctc cgacaaaact cacacatccc caccgtcccc agcacctgaa       60

ctcctggggg gatcctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      120

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      180

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      240

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      300

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      360

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      420

tcccgggacg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      480

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      540

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      600

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcacga ggctctgcac      660

aaccactaca cgcagaagag cctctccctg tctccgggta aaatggcgac cggcggctat      720

cggagcagcg gcagcaccac ggacttcctg gaggagtgga aagcgaagcg cgagaagatg      780

cgcgccaagc agaaccccgt gggcccgggt tcgagcggcg gggatccagc cgccaagtcc      840

cctgcgggac cgctcgccca gactacggcc gcggggacct cggaactcaa ccacggcccc      900

gccggcgcgg ccgcacctgc cgcccccggg ccgggcgccc tgaactgcgc tcacggctcg      960

tccgcgctgc cccgcggggc tcccggctcc cggcggccgg aggacgagtg tcctattgcc     1020

gctggggccg cgggagcacc cgcgtcccgg ggagacgagg aggagccgga tagcgccccg     1080

gagaagggcc gcagctcggg gcccagcgcc aggaaaggca aagggcagat cgagaagagg     1140

aagctgcggg agaagcgccg ctccaccggc gtggtcaaca tccccgcggc ggagtgctta     1200

gatgagtacg aagatgacga agcaggacag aaggaacgga agcgagagga tgctatcaca     1260

cagcagaaca ccatccagaa tgaagctgcg agcctcccag atccaggaac ctcctacctg     1320

ccccaggacc cgtcgagaac agtcccaggc agatacaaaa gcacaatcag tgccccagaa     1380

gaagaaatct taaatagata tccccgaaca gatagaagtg gcttcagtag acacaacaga     1440

gataccagtg cgcctgctaa cttcgcttca agtagcacct tggaaaagag aattgaagat     1500

cttgagaagg aagtcttgag agaaaggcaa gaaaaccttc gacttacgag gctgatgcaa     1560

gataaagaag aaatgattgg aaaactcaag gaagagattg atttgttaaa tagagacctc     1620

gatgacatgg aagacgaaaa cgagcaacta aagcaggaaa ataaaactct tttgaaagtt     1680

gttgggcagc tgacaaggta g                                               1701


<210>  6
<211>  566
<212>  PRT
<213>  Artificial

<220>
<223>  Modified Polypeptide Sequence, Synthetic

<400>  6

Met Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Met Ala Thr Gly Gly Tyr 
225                 230                 235                 240 


Arg Ser Ser Gly Ser Thr Thr Asp Phe Leu Glu Glu Trp Lys Ala Lys 
                245                 250                 255     


Arg Glu Lys Met Arg Ala Lys Gln Asn Pro Val Gly Pro Gly Ser Ser 
            260                 265                 270         


Gly Gly Asp Pro Ala Ala Lys Ser Pro Ala Gly Pro Leu Ala Gln Thr 
        275                 280                 285             


Thr Ala Ala Gly Thr Ser Glu Leu Asn His Gly Pro Ala Gly Ala Ala 
    290                 295                 300                 


Ala Pro Ala Ala Pro Gly Pro Gly Ala Leu Asn Cys Ala His Gly Ser 
305                 310                 315                 320 


Ser Ala Leu Pro Arg Gly Ala Pro Gly Ser Arg Arg Pro Glu Asp Glu 
                325                 330                 335     


Cys Pro Ile Ala Ala Gly Ala Ala Gly Ala Pro Ala Ser Arg Gly Asp 
            340                 345                 350         


Glu Glu Glu Pro Asp Ser Ala Pro Glu Lys Gly Arg Ser Ser Gly Pro 
        355                 360                 365             


Ser Ala Arg Lys Gly Lys Gly Gln Ile Glu Lys Arg Lys Leu Arg Glu 
    370                 375                 380                 


Lys Arg Arg Ser Thr Gly Val Val Asn Ile Pro Ala Ala Glu Cys Leu 
385                 390                 395                 400 


Asp Glu Tyr Glu Asp Asp Glu Ala Gly Gln Lys Glu Arg Lys Arg Glu 
                405                 410                 415     


Asp Ala Ile Thr Gln Gln Asn Thr Ile Gln Asn Glu Ala Ala Ser Leu 
            420                 425                 430         


Pro Asp Pro Gly Thr Ser Tyr Leu Pro Gln Asp Pro Ser Arg Thr Val 
        435                 440                 445             


Pro Gly Arg Tyr Lys Ser Thr Ile Ser Ala Pro Glu Glu Glu Ile Leu 
    450                 455                 460                 


Asn Arg Tyr Pro Arg Thr Asp Arg Ser Gly Phe Ser Arg His Asn Arg 
465                 470                 475                 480 


Asp Thr Ser Ala Pro Ala Asn Phe Ala Ser Ser Ser Thr Leu Glu Lys 
                485                 490                 495     


Arg Ile Glu Asp Leu Glu Lys Glu Val Leu Arg Glu Arg Gln Glu Asn 
            500                 505                 510         


Leu Arg Leu Thr Arg Leu Met Gln Asp Lys Glu Glu Met Ile Gly Lys 
        515                 520                 525             


Leu Lys Glu Glu Ile Asp Leu Leu Asn Arg Asp Leu Asp Asp Met Glu 
    530                 535                 540                 


Asp Glu Asn Glu Gln Leu Lys Gln Glu Asn Lys Thr Leu Leu Lys Val 
545                 550                 555                 560 


Val Gly Gln Leu Thr Arg 
                565     


<210>  7
<211>  1725
<212>  DNA
<213>  Artificial

<220>
<223>  Modified nucleic acid sequence, Synthetic

<400>  7
atgcaggagc ctaagtcctc cgacaaaact cacacatccc caccgtcccc agcacctgaa       60

ctcctggggg gatcctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      120

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      180

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      240

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      300

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      360

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      420

tcccgggacg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      480

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      540

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      600

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcacga ggctctgcac      660

aaccactaca cgcagaagag cctctccctg tctccgggta aaatggcgac cggtggctac      720

cggaccagca gcggcctcgg cggcagcacc acagacttcc tggaggagtg gaaggcgaaa      780

cgcgagaaga tgcgcgccaa gcagaacccc ccgggcccgg cccccccggg agggggcagc      840

agcgacgccg ctgggaagcc ccccgcgggg gctctgggca ccccggcggc cgccgctgcc      900

aacgagctca acaacaacct cccgggcggc gcgccggccg cacctgccgt ccccggtccc      960

gggggcgtga actgcgcggt cggctccgcc atgctgacgc gggcggcccc cggcccgcgg     1020

cggtcggagg acgagccccc agccgcctct gcctcggctg caccgccgcc ccagcgtgac     1080

gaggaggagc cggacggcgt cccagagaag ggcaagagct cgggccccag tgccaggaaa     1140

ggcaaggggc agatcgagaa gaggaagctg cgggagaagc ggcgctccac cggcgtggtc     1200

aacatccctg ccgcagagtg cttagatgag tacgaagatg atgaagcagg gcagaaagag     1260

cggaaacgag aagatgcaat tacacaacag aacactattc agaatgaagc tgtaaactta     1320

ctagatccag gcagttccta tctgctacag gagccaccta gaacagtttc aggcagatat     1380

aaaagcacaa ccagtgtctc tgaagaagat gtctcaagta gatattctcg aacagataga     1440

agtgggttcc ctagatataa cagggatgca aatgtttcag gtactctggt ttcaagtagc     1500

acactggaaa agaaaattga agatcttgaa aaggaagtag taagagaaag acaagaaaac     1560

ctaagacttg tgagactgat gcaagataaa gaggaaatga ttggaaaact caaagaagaa     1620

attgatttat taaatagaga cctagatgac atagaagatg aaaatgaaca gctaaagcag     1680

gaaaataaaa ctcttttgaa agttgtgggt cagctgacca ggtag                     1725


<210>  8
<211>  574
<212>  PRT
<213>  Artificial

<220>
<223>  Modified polypeptide sequence, Synthetic

<400>  8

Met Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Met Ala Thr Gly Gly Tyr 
225                 230                 235                 240 


Arg Thr Ser Ser Gly Leu Gly Gly Ser Thr Thr Asp Phe Leu Glu Glu 
                245                 250                 255     


Trp Lys Ala Lys Arg Glu Lys Met Arg Ala Lys Gln Asn Pro Pro Gly 
            260                 265                 270         


Pro Ala Pro Pro Gly Gly Gly Ser Ser Asp Ala Ala Gly Lys Pro Pro 
        275                 280                 285             


Ala Gly Ala Leu Gly Thr Pro Ala Ala Ala Ala Ala Asn Glu Leu Asn 
    290                 295                 300                 


Asn Asn Leu Pro Gly Gly Ala Pro Ala Ala Pro Ala Val Pro Gly Pro 
305                 310                 315                 320 


Gly Gly Val Asn Cys Ala Val Gly Ser Ala Met Leu Thr Arg Ala Ala 
                325                 330                 335     


Pro Gly Pro Arg Arg Ser Glu Asp Glu Pro Pro Ala Ala Ser Ala Ser 
            340                 345                 350         


Ala Ala Pro Pro Pro Gln Arg Asp Glu Glu Glu Pro Asp Gly Val Pro 
        355                 360                 365             


Glu Lys Gly Lys Ser Ser Gly Pro Ser Ala Arg Lys Gly Lys Gly Gln 
    370                 375                 380                 


Ile Glu Lys Arg Lys Leu Arg Glu Lys Arg Arg Ser Thr Gly Val Val 
385                 390                 395                 400 


Asn Ile Pro Ala Ala Glu Cys Leu Asp Glu Tyr Glu Asp Asp Glu Ala 
                405                 410                 415     


Gly Gln Lys Glu Arg Lys Arg Glu Asp Ala Ile Thr Gln Gln Asn Thr 
            420                 425                 430         


Ile Gln Asn Glu Ala Val Asn Leu Leu Asp Pro Gly Ser Ser Tyr Leu 
        435                 440                 445             


Leu Gln Glu Pro Pro Arg Thr Val Ser Gly Arg Tyr Lys Ser Thr Thr 
    450                 455                 460                 


Ser Val Ser Glu Glu Asp Val Ser Ser Arg Tyr Ser Arg Thr Asp Arg 
465                 470                 475                 480 


Ser Gly Phe Pro Arg Tyr Asn Arg Asp Ala Asn Val Ser Gly Thr Leu 
                485                 490                 495     


Val Ser Ser Ser Thr Leu Glu Lys Lys Ile Glu Asp Leu Glu Lys Glu 
            500                 505                 510         


Val Val Arg Glu Arg Gln Glu Asn Leu Arg Leu Val Arg Leu Met Gln 
        515                 520                 525             


Asp Lys Glu Glu Met Ile Gly Lys Leu Lys Glu Glu Ile Asp Leu Leu 
    530                 535                 540                 


Asn Arg Asp Leu Asp Asp Ile Glu Asp Glu Asn Glu Gln Leu Lys Gln 
545                 550                 555                 560 


Glu Asn Lys Thr Leu Leu Lys Val Val Gly Gln Leu Thr Arg 
                565                 570                 


