                         SEQUENCE LISTING

<110>  VASCULAR BIOGENICS LTD.
        
<120>  METHODS FOR ANTI-TUMOR THERAPY

<130>  3182.091PC01/GLL/C-K/SGM

<150>  US 62/833,402
<151>  2019-04-12

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding TNFR1

<400>  1
atgggcctct ccaccgtgcc tgacctgctg ctgccgctgg tgctcctgga gctgttggtg       60

ggaatatacc cctcaggggt tattggactg gtccctcacc taggggacag ggagaagaga      120

gatagtgtgt gtccccaagg aaaatatatc caccctcaaa ataattcgat ttgctgtacc      180

aagtgccaca aaggaaccta cttgtacaat gactgtccag gcccggggca ggatacggac      240

tgcagggagt gtgagagcgg ctccttcacc gcttcagaaa accacctcag acactgcctc      300

agctgctcca aatgccgaaa ggaaatgggt caggtggaga tctcttcttg cacagtggac      360

cgggacaccg tgtgtggctg caggaagaac cagtaccggc attattggag tgaaaacctt      420

ttccagtgct tcaattgcag cctctgcctc aatgggaccg tgcacctctc ctgccaggag      480

aaacagaaca ccgtgtgcac ctgccatgca ggtttctttc taagagaaaa cgagtgtgtc      540

tcctgtagta actgtaagaa aagcctggag tgcacgaagt tgtgcctacc ccagattgag      600

aatgttaagg gcactgagga ctcaggcacc acagtgctgt tgcccctggt cattttcttt      660

ggtctttgcc ttttatccct cctcttcatt ggtttaatgt atcgctacca acggtggaag      720

tccaagctct actccattgt ttgtgggaaa tcgacacctg aaaaagaggg ggagcttgaa      780

ggaactacta ctaagcccct ggccccaaac ccaagcttca gtcccactcc aggcttcacc      840

cccaccctgg gcttcagtcc cgtgcccagt tccaccttca cctccagctc cacctatacc      900

cccggtgact gtcccaactt tgcggctccc cgcagagagg tggcaccacc ctatcagggg      960

gctgacccca tccttgcgac agccctcgcc tccgacccca tccccaaccc ccttcagaag     1020

tgggaggaca gcgcccacaa gccacagagc ctagacactg atgaccccgc gacgctgtac     1080

gccgtggtgg agaacgtgcc cccgttgcgc tggaaggaat tcgtgcggcg cctagggctg     1140

agcgaccacg agatcgatcg gctggagctg cagaacgggc gctgcctgcg cgaggcgcaa     1200

tacagcatgc tggcgacctg gaggcggcgc acgccgcggc gcgaggccac gctggagctg     1260

ctgggacgcg tgctccgcga catggacctg ctgggctgcc tggaggacat cgaggaggcg     1320

ctttgcggcc ccgccgccct cccgcccgcg cccagtcttc tcaga                     1365


<210>  2
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of TNFR1

<400>  2

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  3
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding a Ligand Binding Domain of TNFR1

<400>  3
atgggcctct ccaccgtgcc tgacctgctg ctgccgctgg tgctcctgga gctgttggtg       60

ggaatatacc cctcaggggt tattggactg gtccctcacc taggggacag ggagaagaga      120

gatagtgtgt gtccccaagg aaaatatatc caccctcaaa ataattcgat ttgctgtacc      180

aagtgccaca aaggaaccta cttgtacaat gactgtccag gcccggggca ggatacggac      240

tgcagggagt gtgagagcgg ctccttcacc gcttcagaaa accacctcag acactgcctc      300

agctgctcca aatgccgaaa ggaaatgggt caggtggaga tctcttcttg cacagtggac      360

cgggacaccg tgtgtggctg caggaagaac cagtaccggc attattggag tgaaaacctt      420

ttccagtgct tcaattgcag cctctgcctc aatgggaccg tgcacctctc ctgccaggag      480

aaacagaaca ccgtgtgcac ctgccatgca ggtttctttc taagagaaaa cgagtgtgtc      540

tcctgtagta actgtaagaa aagcctggag tgcacgaagt tgtgcctacc a               591


<210>  4
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a Ligand Binding Domain of TNFR1

<400>  4

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro 
        195         


<210>  5
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full-length FAS

<400>  5
atgctgggca tctggaccct cctacctctg gttcttacgt ctgttgctag attatcgtcc       60

aaaagtgtta atgcccaagt gactgacatc aactccaagg gattggaatt gaggaagact      120

gttactacag ttgagactca gaacttggaa ggcctgcatc atgatggcca attctgccat      180

aagccctgtc ctccaggtga aaggaaagct agggactgca cagtcaatgg ggatgaacca      240

gactgcgtgc cctgccaaga agggaaggag tacacagaca aagcccattt ttcttccaaa      300

tgcagaagat gtagattgtg tgatgaagga catggcttag aagtggaaat aaactgcacc      360

cggacccaga ataccaagtg cagatgtaaa ccaaactttt tttgtaactc tactgtatgt      420

gaacactgtg acccttgcac caaatgtgaa catggaatca tcaaggaatg cacactcacc      480

agcaacacca agtgcaaaga ggaaggatcc agatctaact tggggtggct ttgtcttctt      540

cttttgccaa ttccactaat tgtttgggtg aagagaaagg aagtacagaa aacatgcaga      600

aagcacagaa aggaaaacca aggttctcat gaatctccaa ctttaaatcc tgaaacagtg      660

gcaataaatt tatctgatgt tgacttgagt aaatatatca ccactattgc tggagtcatg      720

acactaagtc aagttaaagg ctttgttcga aagaatggtg tcaatgaagc caaaatagat      780

gagatcaaga atgacaatgt ccaagacaca gcagaacaga aagttcaact gcttcgtaat      840

tggcatcaac ttcatggaaa gaaagaagcg tatgacacat tgattaaaga tctcaaaaaa      900

gccaatcttt gtactcttgc agagaaaatt cagactatca tcctcaagga cattactagt      960

gactcagaaa attcaaactt cagaaatgaa atccaaagct tggtctag                  1008


<210>  6
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length FAS

<400>  6

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  7
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Effector Domain of FAS

<400>  7
aggatccaga tctaacttgg ggtggctttg tcttcttctt ttgccaattc cactaattgt       60

ttgggtgaag agaaaggaag tacagaaaac atgcagaaag cacagaaagg aaaaccaagg      120

ttctcatgaa tctccaacct taaatcctga aacagtggca ataaatttat ctgatgttga      180

cttgagtaaa tatatcacca ctattgctgg agtcatgaca ctaagtcaag ttaaaggctt      240

tgttcgaaag aatggtgtca atgaagccaa aatagatgag atcaagaatg acaatgtcca      300

agacacagca gaacagaaag ttcaactgct tcgtaattgg catcaacttc atggaaagaa      360

agaagcgtat gacacattga ttaaagatct caaaaaagcc aatctttgta ctcttgcaga      420

gaaaattcag actatcatcc tcaaggacat tactagtgac tcagaaaatt caaacttcag      480

aaatgaaatc caaagcttgg tctag                                            505


<210>  8
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Effector Domain of FAS

<400>  8

Gly Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile 
1               5                   10                  15      


Pro Leu Ile Val Trp Val Lys Arg Lys Glu Val Gln Lys Thr Cys Arg 
            20                  25                  30          


Lys His Arg Lys Glu Asn Gln Gly Ser His Glu Ser Pro Thr Leu Asn 
        35                  40                  45              


Pro Glu Thr Val Ala Ile Asn Leu Ser Asp Val Asp Leu Ser Lys Tyr 
    50                  55                  60                  


Ile Thr Thr Ile Ala Gly Val Met Thr Leu Ser Gln Val Lys Gly Phe 
65                  70                  75                  80  


Val Arg Lys Asn Gly Val Asn Glu Ala Lys Ile Asp Glu Ile Lys Asn 
                85                  90                  95      


Asp Asn Val Gln Asp Thr Ala Glu Gln Lys Val Gln Leu Leu Arg Asn 
            100                 105                 110         


Trp His Gln Leu His Gly Lys Lys Glu Ala Tyr Asp Thr Leu Ile Lys 
        115                 120                 125             


Asp Leu Lys Lys Ala Asn Leu Cys Thr Leu Ala Glu Lys Ile Gln Thr 
    130                 135                 140                 


Ile Ile Leu Lys Asp Ile Thr Ser Asp Ser Glu Asn Ser Asn Phe Arg 
145                 150                 155                 160 


Asn Glu Ile Gln Ser Leu Val 
                165         


<210>  9
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAS-chimera

<400>  9
atgggcctct ccaccgtgcc tgacctgctg ctgccgctgg tgctcctgga gctgttggtg       60

ggaatatacc cctcaggggt tattggactg gtccctcacc taggggacag ggagaagaga      120

gatagtgtgt gtccccaagg aaaatatatc caccctcaaa ataattcgat ttgctgtacc      180

aagtgccaca aaggaaccta cttgtacaat gactgtccag gcccggggca ggatacggac      240

tgcagggagt gtgagagcgg ctccttcacc gcttcagaaa accacctcag acactgcctc      300

agctgctcca aatgccgaaa ggaaatgggt caggtggaga tctcttcttg cacagtggac      360

cgggacaccg tgtgtggctg caggaagaac cagtaccggc attattggag tgaaaacctt      420

ttccagtgct tcaattgcag cctctgcctc aatgggaccg tgcacctctc ctgccaggag      480

aaacagaaca ccgtgtgcac ctgccatgca ggtttctttc taagagaaaa cgagtgtgtc      540

tcctgtagta actgtaagaa aagcctggag tgcacgaagt tgtgcctacc aagcttagga      600

tccagatcta acttggggtg gctttgtctt cttcttttgc caattccact aattgtttgg      660

gtgaagagaa aggaagtaca gaaaacatgc agaaagcaca gaaaggaaaa ccaaggttct      720

catgaatctc caaccttaaa tcctgaaaca gtggcaataa atttatctga tgttgacttg      780

agtaaatata tcaccactat tgctggagtc atgacactaa gtcaagttaa aggctttgtt      840

cgaaagaatg gtgtcaatga agccaaaata gatgagatca agaatgacaa tgtccaagac      900

acagcagaac agaaagttca actgcttcgt aattggcatc aacttcatgg aaagaaagaa      960

gcgtatgaca cattgattaa agatctcaaa aaagccaatc tttgtactct tgcagagaaa     1020

attcagacta tcatcctcaa ggacattact agtgactcag aaaattcaaa cttcagaaat     1080

gaaatccaaa gcttggtcta g                                               1101


<210>  10
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAS-chimera

<400>  10

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Ser Leu Gly Ser Arg Ser Asn Leu Gly Trp Leu 
        195                 200                 205             


Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg Lys 
    210                 215                 220                 


Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser 
225                 230                 235                 240 


His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Ser 
                245                 250                 255     


Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met Thr 
            260                 265                 270         


Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu Ala 
        275                 280                 285             


Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu Gln 
    290                 295                 300                 


Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys Glu 
305                 310                 315                 320 


Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys Thr 
                325                 330                 335     


Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser Asp 
            340                 345                 350         


Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
        355                 360                 365     


<210>  11
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  11
ctggagggtg actttgcttc tggagccagt acttcatact tttcatt                     47


<210>  12
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  12
aatgaaaagt atgaagtact ggctccagaa gcaaagtcac cctccag                     47


<210>  13
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  13
gtacttcata cttttcattc caatggggtg actttgcttc tgga                        44


<210>  14
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  14
tccagaagca aagtcacccc attggaatga aaagtatgaa gtac                        44


<210>  15
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  15
ctccagaagc aaagtcaccc cattggaatg aaaagtatga agtacaatga aaagtatgaa       60

gtactggctc cagaagcaaa gtcaccctcc agaagcaaag tcaccccatt ggaatgaaaa      120

gtatgaagta c                                                           131


<210>  16
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  16
gtacttcata cttttcattc caatggggtg actttgcttc tggagggtga ctttgcttct       60

ggagccagta cttcatactt ttcattgtac ttcatacttt tcattccaat ggggtgactt      120

tgcttctgga g                                                           131


<210>  17
<211>  850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Endothelial Cell-Specific PPE-1 Promoter

<400>  17
gtacgtgtac ttctgatcgg cgatactagg gagataagga tgtgcctgac aaaaccacat       60

tgttgttgtt atcattatta tttagttttc cttccttgct aactcctgac ggaatctttc      120

tcacctcaaa tgcgaagtac tttagtttag aaaagacttg gtggaagggg tggtggtgga      180

aaagtagggt gatcttccaa actaatctgg ttccccgccc gccccagtag ctgggattca      240

agagcgaaga gtggggatcg tccccttgtt tgatcagaaa gacataaaag gaaaatcaag      300

tgaacaatga tcagccccac ctccacccca cccccctgcg cgcgcacaat acaatctatt      360

taattgtact tcatactttt cattccaatg gggtgacttt gcttctggag aaactcttga      420

ttcttgaact ctggggctgg cagctagcaa aaggggaagc gggctgctgc tctctgcagg      480

ttctgcagcg gtctctgtct agtgggtgtt ttctttttct tagccctgcc cctggattgt      540

cagacggcgg gcgtctgcct ctgaagttag ccgtgatttc ctctagagcc gggtcttatc      600

tctggctgca cgttgcctgt gggtgactaa tcacacaata acattgttta gggctggaat      660

gaagtcagag ctgtttaccc ccactctata ggggttcaat ataaaaaggc ggcggagaac      720

tgtccgagtc agaagcgttc ctgcaccggc gctgagagcc tgacccggtc tgctccgctg      780

tccttgcgcg ctgcctcccg gctgcccgcg acgctttcgc cccagtggaa gggccacttg      840

ctgcggccgc                                                             850


<210>  18
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Endothelial Cell-Specific PPE-1 3X Promoter

<400>  18
gtacgtgtac ttctgatcgg cgatactagg gagataagga tgtgcctgac aaaaccacat       60

tgttgttgtt atcattatta tttagttttc cttccttgct aactcctgac ggaatctttc      120

tcacctcaaa tgcgaagtac tttagtttag aaaagacttg gtggaagggg tggtggtgga      180

aaagtagggt gatcttccaa actaatctgg ttccccgccc gccccagtag ctgggattca      240

agagcgaaga gtggggatcg tccccttgtt tgatcagaaa gacataaaag gaaaatcaag      300

tgaacaatga tcagccccac ctccacccca cccccctgcg cgcgcacaat acaatctatt      360

taattgtact tcatactttt cattccaatg gggtgacttt gcttctggag aaactcttga      420

ttcttgaact ctggggctgg cagctagcct ccagaagcaa agtcacccca ttggaatgaa      480

aagtatgaag tacaatgaaa agtatgaagt actggctcca gaagcaaagt caccctccag      540

aagcaaagtc accccattgg aatgaaaagt atgaagtacg ctagcaaaag gggaagcggg      600

ctgctgctct ctgcaggttc tgcagcggtc tctgtctagt gggtgttttc tttttcttag      660

ccctgcccct ggattgtcag acggcgggcg tctgcctctg aagttagccg tgatttcctc      720

tagagccggg tcttatctct ggctgcacgt tgcctgtggg tgactaatca cacaataaca      780

ttgtttaggg ctggaatgaa gtcagagctg tttaccccca ctctataggg gttcaatata      840

aaaaggcggc ggagaactgt ccgagtcaga agcgttcctg caccggcgct gagagcctga      900

cccggtctgc tccgctgtcc ttgcgcgctg cctcccggct gcccgcgacg ctttcgcccc      960

agtggaaggg ccacttgctg cggccgc                                          987


<210>  19
<211>  35207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VB-111 entire construct

<400>  19
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag      240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga      300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg      360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc      420

cgggtcaaag ttggcgtttt attattatag tcagtacgta cgtgtacttc tgatcggcga      480

tactagggag ataaggatgt gcctgacaaa accacattgt tgttgttatc attattattt      540

agttttcctt ccttgctaac tcctgacgga atctttctca cctcaaatgc gaagtacttt      600

agtttagaaa agacttggtg gaaggggtgg tggtggaaaa gtagggtgat cttccaaact      660

aatctggttc cccgcccgcc ccagtagctg ggattcaaga gcgaagagtg gggatcgtcc      720

ccttgtttga tcagaaagac ataaaaggaa aatcaagtga acaatgatca gccccacctc      780

caccccaccc ccctgcgcgc gcacaataca atctatttaa ttgtacttca tacttttcat      840

tccaatgggg tgactttgct tctggagaaa ctcttgattc ttgaactctg gggctggcag      900

ctagcctcca gaagcaaagt caccccattg gaatgaaaag tatgaagtac aatgaaaagt      960

atgaagtact ggctccagaa gcaaagtcac cctccagaag caaagtcacc ccattggaat     1020

gaaaagtatg aagtacgcta gcaaaagggg aagcgggctg ctgctctctg caggttctgc     1080

agcggtctct gtctagtggg tgttttcttt ttcttagccc tgcccctgga ttgtcagacg     1140

gcgggcgtct gcctctgaag ttagccgtga tttcctctag agccgggtct tatctctggc     1200

tgcacgttgc ctgtgggtga ctaatcacac aataacattg tttagggctg gaatgaagtc     1260

agagctgttt acccccactc tataggggtt caatataaaa aggcggcgga gaactgtccg     1320

agtcagaagc gttcctgcac cggcgctgag agcctgaccc ggtctgctcc gctgtccttg     1380

cgcgctgcct cccggctgcc cgcgacgctt tcgccccagt ggaagggcca cttgctgcgg     1440

ccgctaattc tgcagatcgg gatccggcat gggcctctcc accgtgcctg acctgctgct     1500

gccgctggtg ctcctggagc tgttggtggg aatatacccc tcaggggtta ttggactggt     1560

ccctcaccta ggggacaggg agaagagaga tagtgtgtgt ccccaaggaa aatatatcca     1620

ccctcaaaat aattcgattt gctgtaccaa gtgccacaaa ggaacctact tgtacaatga     1680

ctgtccaggc ccggggcagg atacggactg cagggagtgt gagagcggct ccttcaccgc     1740

ttcagaaaac cacctcagac actgcctcag ctgctccaaa tgccgaaagg aaatgggtca     1800

ggtggagatc tcttcttgca cagtggaccg ggacaccgtg tgtggctgca ggaagaacca     1860

gtaccggcat tattggagtg aaaacctttt ccagtgcttc aattgcagcc tctgcctcaa     1920

tgggaccgtg cacctctcct gccaggagaa acagaacacc gtgtgcacct gccatgcagg     1980

tttctttcta agagaaaacg agtgtgtctc ctgtagtaac tgtaagaaaa gcctggagtg     2040

cacgaagttg tgcctaccaa gcttaggatc cagatctaac ttggggtggc tttgtcttct     2100

tcttttgcca attccactaa ttgtttgggt gaagagaaag gaagtacaga aaacatgcag     2160

aaagcacaga aaggaaaacc aaggttctca tgaatctcca accttaaatc ctgaaacagt     2220

ggcaataaat ttatctgatg ttgacttgag taaatatatc accactattg ctggagtcat     2280

gacactaagt caagttaaag gctttgttcg aaagaatggt gtcaatgaag ccaaaataga     2340

tgagatcaag aatgacaatg tccaagacac agcagaacag aaagttcaac tgcttcgtaa     2400

ttggcatcaa cttcatggaa agaaagaagc gtatgacaca ttgattaaag atctcaaaaa     2460

agccaatctt tgtactcttg cagagaaaat tcagactatc atcctcaagg acattactag     2520

tgactcagaa aattcaaact tcagaaatga aatccaaagc ttggtctagc tcgagcatgc     2580

atctaggcgg ccgcatggca gaaattcgcg aattcgctag cgttaacgga tcctctagac     2640

gagatccgaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     2700

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     2760

atgtatctta tcatgtctag atctgtactg aaatgtgtgg gcgtggctta agggtgggaa     2820

agaatatata aggtgggggt cttatgtagt tttgtatctg ttttgcagca gccgccgccg     2880

ccatgagcac caactcgttt gatggaagca ttgtgagctc atatttgaca acgcgcatgc     2940

ccccatgggc cggggtgcgt cagaatgtga tgggctccag cattgatggt cgccccgtcc     3000

tgcccgcaaa ctctactacc ttgacctacg agaccgtgtc tggaacgccg ttggagactg     3060

cagcctccgc cgccgcttca gccgctgcag ccaccgcccg cgggattgtg actgactttg     3120

ctttcctgag cccgcttgca agcagtgcag cttcccgttc atccgcccgc gatgacaagt     3180

tgacggctct tttggcacaa ttggattctt tgacccggga acttaatgtc gtttctcagc     3240

agctgttgga tctgcgccag caggtttctg ccctgaaggc ttcctcccct cccaatgcgg     3300

tttaaaacat aaataaaaaa ccagactctg tttggatttg gatcaagcaa gtgtcttgct     3360

gtctttattt aggggttttg cgcgcgcggt aggcccggga ccagcggtct cggtcgttga     3420

gggtcctgtg tattttttcc aggacgtggt aaaggtgact ctggatgttc agatacatgg     3480

gcataagccc gtctctgggg tggaggtagc accactgcag agcttcatgc tgcggggtgg     3540

tgttgtagat gatccagtcg tagcaggagc gctgggcgtg gtgcctaaaa atgtctttca     3600

gtagcaagct gattgccagg ggcaggccct tggtgtaagt gtttacaaag cggttaagct     3660

gggatgggtg catacgtggg gatatgagat gcatcttgga ctgtattttt aggttggcta     3720

tgttcccagc catatccctc cggggattca tgttgtgcag aaccaccagc acagtgtatc     3780

cggtgcactt gggaaatttg tcatgtagct tagaaggaaa tgcgtggaag aacttggaga     3840

cgcccttgtg acctccaaga ttttccatgc attcgtccat aatgatggca atgggcccac     3900

gggcggcggc ctgggcgaag atatttctgg gatcactaac gtcatagttg tgttccagga     3960

tgagatcgtc ataggccatt tttacaaagc gcgggcggag ggtgccagac tgcggtataa     4020

tggttccatc cggcccaggg gcgtagttac cctcacagat ttgcatttcc cacgctttga     4080

gttcagatgg ggggatcatg tctacctgcg gggcgatgaa gaaaacggtt tccggggtag     4140

gggagatcag ctgggaagaa agcaggttcc tgagcagctg cgacttaccg cagccggtgg     4200

gcccgtaaat cacacctatt accggctgca actggtagtt aagagagctg cagctgccgt     4260

catccctgag caggggggcc acttcgttaa gcatgtccct gactcgcatg ttttccctga     4320

ccaaatccgc cagaaggcgc tcgccgccca gcgatagcag ttcttgcaag gaagcaaagt     4380

ttttcaacgg tttgagaccg tccgccgtag gcatgctttt gagcgtttga ccaagcagtt     4440

ccaggcggtc ccacagctcg gtcacctgct ctacggcatc tcgatccagc atatctcctc     4500

gtttcgcggg ttggggcggc tttcgctgta cggcagtagt cggtgctcgt ccagacgggc     4560

cagggtcatg tctttccacg ggcgcagggt cctcgtcagc gtagtctggg tcacggtgaa     4620

ggggtgcgct ccgggctgcg cgctggccag ggtgcgcttg aggctggtcc tgctggtgct     4680

gaagcgctgc cggtcttcgc cctgcgcgtc ggccaggtag catttgacca tggtgtcata     4740

gtccagcccc tccgcggcgt ggcccttggc gcgcagcttg cccttggagg aggcgccgca     4800

cgaggggcag tgcagacttt tgagggcgta gagcttgggc gcgagaaata ccgattccgg     4860

ggagtaggca tccgcgccgc aggccccgca gacggtctcg cattccacga gccaggtgag     4920

ctctggccgt tcggggtcaa aaaccaggtt tcccccatgc tttttgatgc gtttcttacc     4980

tctggtttcc atgagccggt gtccacgctc ggtgacgaaa aggctgtccg tgtccccgta     5040

tacagacttg agaggcctgt cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc     5100

ggaccactct gagacaaagg ctcgcgtcca ggccagcacg aaggaggcta agtgggaggg     5160

gtagcggtcg ttgtccacta gggggtccac tcgctccagg gtgtgaagac acatgtcgcc     5220

ctcttcggca tcaaggaagg tgattggttt gtaggtgtag gccacgtgac cgggtgttcc     5280

tgaagggggg ctataaaagg gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct     5340

gtctgcgagg gccagctgtt ggggtgagta ctccctctga aaagcgggca tgacttctgc     5400

gctaagattg tcagtttcca aaaacgagga ggatttgata ttcacctggc ccgcggtgat     5460

gcctttgagg gtggccgcat ccatctggtc agaaaagaca atctttttgt tgtcaagctt     5520

ggtggcaaac gacccgtaga gggcgttgga cagcaacttg gcgatggagc gcagggtttg     5580

gtttttgtcg cgatcggcgc gctccttggc cgcgatgttt agctgcacgt attcgcgcgc     5640

aacgcaccgc cattcgggaa agacggtggt gcgctcgtcg ggcaccaggt gcacgcgcca     5700

accgcggttg tgcagggtga caaggtcaac gctggtggct acctctccgc gtaggcgctc     5760

gttggtccag cagaggcggc cgcccttgcg cgagcagaat ggcggtaggg ggtctagctg     5820

cgtctcgtcc ggggggtctg cgtccacggt aaagaccccg ggcagcaggc gcgcgtcgaa     5880

gtagtctatc ttgcatcctt gcaagtctag cgcctgctgc catgcgcggg cggcaagcgc     5940

gcgctcgtat gggttgagtg ggggacccca tggcatgggg tgggtgagcg cggaggcgta     6000

catgccgcaa atgtcgtaaa cgtagagggg ctctctgagt attccaagat atgtagggta     6060

gcatcttcca ccgcggatgc tggcgcgcac gtaatcgtat agttcgtgcg agggagcgag     6120

gaggtcggga ccgaggttgc tacgggcggg ctgctctgct cggaagacta tctgcctgaa     6180

gatggcatgt gagttggatg atatggttgg acgctggaag acgttgaagc tggcgtctgt     6240

gagacctacc gcgtcacgca cgaaggaggc gtaggagtcg cgcagcttgt tgaccagctc     6300

ggcggtgacc tgcacgtcta gggcgcagta gtccagggtt tccttgatga tgtcatactt     6360

atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc ggtctttcca     6420

gtactcttgg atcggaaacc cgtcggcctc cgaacggtaa gagcctagca tgtagaactg     6480

gttgacggcc tggtaggcgc agcatccctt ttctacgggt agcgcgtatg cctgcgcggc     6540

cttccggagc gaggtgtggg tgagcgcaaa ggtgtccctg accatgactt tgaggtactg     6600

gtatttgaag tcagtgtcgt cgcatccgcc ctgctcccag agcaaaaagt ccgtgcgctt     6660

tttggaacgc ggatttggca gggcgaaggt gacatcgttg aagagtatct ttcccgcgcg     6720

aggcataaag ttgcgtgtga tgcggaaggg tcccggcacc tcggaacggt tgttaattac     6780

ctgggcggcg agcacgatct cgtcaaagcc gttgatgttg tggcccacaa tgtaaagttc     6840

caagaagcgc gggatgccct tgatggaagg caatttttta agttcctcgt aggtgagctc     6900

ttcaggggag ctgagcccgt gctctgaaag ggcccagtct gcaagatgag ggttggaagc     6960

gacgaatgag ctccacaggt cacgggccat tagcatttgc aggtggtcgc gaaaggtcct     7020

aaactggcga cctatggcca ttttttctgg ggtgatgcag tagaaggtaa gcgggtcttg     7080

ttcccagcgg tcccatccaa ggttcgcggc taggtctcgc gcggcagtca ctagaggctc     7140

atctccgccg aacttcatga ccagcatgaa gggcacgagc tgcttcccaa aggcccccat     7200

ccaagtatag gtctctacat cgtaggtgac aaagagacgc tcggtgcgag gatgcgagcc     7260

gatcgggaag aactggatct cccgccacca attggaggag tggctattga tgtggtgaaa     7320

gtagaagtcc ctgcgacggg ccgaacactc gtgctggctt ttgtaaaaac gtgcgcagta     7380

ctggcagcgg tgcacgggct gtacatcctg cacgaggttg acctgacgac cgcgcacaag     7440

gaagcagagt gggaatttga gcccctcgcc tggcgggttt ggctggtggt cttctacttc     7500

ggctgcttgt ccttgaccgt ctggctgctc gaggggagtt acggtggatc ggaccaccac     7560

gccgcgcgag cccaaagtcc agatgtccgc gcgcggcggt cggagcttga tgacaacatc     7620

gcgcagatgg gagctgtcca tggtctggag ctcccgcggc gtcaggtcag gcgggagctc     7680

ctgcaggttt acctcgcata gacgggtcag ggcgcgggct agatccaggt gatacctaat     7740

ttccaggggc tggttggtgg cggcgtcgat ggcttgcaag aggccgcatc cccgcggcgc     7800

gactacggta ccgcgcggcg ggcggtgggc cgcgggggtg tccttggatg atgcatctaa     7860

aagcggtgac gcgggcgagc ccccggaggt agggggggct ccggacccgc cgggagaggg     7920

ggcaggggca cgtcggcgcc gcgcgcgggc aggagctggt gctgcgcgcg taggttgctg     7980

gcgaacgcga cgacgcggcg gttgatctcc tgaatctggc gcctctgcgt gaagacgacg     8040

ggcccggtga gcttgaacct gaaagagagt tcgacagaat caatttcggt gtcgttgacg     8100

gcggcctggc gcaaaatctc ctgcacgtct cctgagttgt cttgataggc gatctcggcc     8160

atgaactgct cgatctcttc ctcctggaga tctccgcgtc cggctcgctc cacggtggcg     8220

gcgaggtcgt tggaaatgcg ggccatgagc tgcgagaagg cgttgaggcc tccctcgttc     8280

cagacgcggc tgtagaccac gcccccttcg gcatcgcggg cgcgcatgac cacctgcgcg     8340

agattgagct ccacgtgccg ggcgaagacg gcgtagtttc gcaggcgctg aaagaggtag     8400

ttgagggtgg tggcggtgtg ttctgccacg aagaagtaca taacccagcg tcgcaacgtg     8460

gattcgttga tatcccccaa ggcctcaagg cgctccatgg cctcgtagaa gtccacggcg     8520

aagttgaaaa actgggagtt gcgcgccgac acggttaact cctcctccag aagacggatg     8580

agctcggcga cagtgtcgcg cacctcgcgc tcaaaggcta caggggcctc ttcttcttct     8640

tcaatctcct cttccataag ggcctcccct tcttcttctt ctggcggcgg tgggggaggg     8700

gggacacggc ggcgacgacg gcgcaccggg aggcggtcga caaagcgctc gatcatctcc     8760

ccgcggcgac ggcgcatggt ctcggtgacg gcgcggccgt tctcgcgggg gcgcagttgg     8820

aagacgccgc ccgtcatgtc ccggttatgg gttggcgggg ggctgccatg cggcagggat     8880

acggcgctaa cgatgcatct caacaattgt tgtgtaggta ctccgccgcc gagggacctg     8940

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag     9000

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg     9060

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac     9120

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag     9180

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc     9240

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg     9300

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc     9360

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc     9420

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg     9480

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc     9540

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc     9600

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt     9660

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg     9720

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg     9780

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc     9840

aggcgcgcgc aatcgttgac gctctagacc gtgcaaaagg agagcctgta agcgggcact     9900

cttccgtggt ctggtggata aattcgcaag ggtatcatgg cggacgaccg gggttcgagc     9960

cccgtatccg gccgtccgcc gtgatccatg cggttaccgc ccgcgtgtcg aacccaggtg    10020

tgcgacgtca gacaacgggg gagtgctcct tttggcttcc ttccaggcgc ggcggctgct    10080

gcgctagctt ttttggccac tggccgcgcg cagcgtaagc ggttaggctg gaaagcgaaa    10140

gcattaagtg gctcgctccc tgtagccgga gggttatttt ccaagggttg agtcgcggga    10200

cccccggttc gagtctcgga ccggccggac tgcggcgaac gggggtttgc ctccccgtca    10260

tgcaagaccc cgcttgcaaa ttcctccgga aacagggacg agcccctttt ttgcttttcc    10320

cagatgcatc cggtgctgcg gcagatgcgc ccccctcctc agcagcggca agagcaagag    10380

cagcggcaga catgcagggc accctcccct cctcctaccg cgtcaggagg ggcgacatcc    10440

gcggttgacg cggcagcaga tggtgattac gaacccccgc ggcgccgggc ccggcactac    10500

ctggacttgg aggagggcga gggcctggcg cggctaggag cgccctctcc tgagcggcac    10560

ccaagggtgc agctgaagcg tgatacgcgt gaggcgtacg tgccgcggca gaacctgttt    10620

cgcgaccgcg agggagagga gcccgaggag atgcgggatc gaaagttcca cgcagggcgc    10680

gagctgcggc atggcctgaa tcgcgagcgg ttgctgcgcg aggaggactt tgagcccgac    10740

gcgcgaaccg ggattagtcc cgcgcgcgca cacgtggcgg ccgccgacct ggtaaccgca    10800

tacgagcaga cggtgaacca ggagattaac tttcaaaaaa gctttaacaa ccacgtgcgt    10860

acgcttgtgg cgcgcgagga ggtggctata ggactgatgc atctgtggga ctttgtaagc    10920

gcgctggagc aaaacccaaa tagcaagccg ctcatggcgc agctgttcct tatagtgcag    10980

cacagcaggg acaacgaggc attcagggat gcgctgctaa acatagtaga gcccgagggc    11040

cgctggctgc tcgatttgat aaacatcctg cagagcatag tggtgcagga gcgcagcttg    11100

agcctggctg acaaggtggc cgccatcaac tattccatgc ttagcctggg caagttttac    11160

gcccgcaaga tataccatac cccttacgtt cccatagaca aggaggtaaa gatcgagggg    11220

ttctacatgc gcatggcgct gaaggtgctt accttgagcg acgacctggg cgtttatcgc    11280

aacgagcgca tccacaaggc cgtgagcgtg agccggcggc gcgagctcag cgaccgcgag    11340

ctgatgcaca gcctgcaaag ggccctggct ggcacgggca gcggcgatag agaggccgag    11400

tcctactttg acgcgggcgc tgacctgcgc tgggccccaa gccgacgcgc cctggaggca    11460

gctggggccg gacctgggct ggcggtggca cccgcgcgcg ctggcaacgt cggcggcgtg    11520

gaggaatatg acgaggacga tgagtacgag ccagaggacg gcgagtacta agcggtgatg    11580

tttctgatca gatgatgcaa gacgcaacgg acccggcggt gcgggcggcg ctgcagagcc    11640

agccgtccgg ccttaactcc acggacgact ggcgccaggt catggaccgc atcatgtcgc    11700

tgactgcgcg caatcctgac gcgttccggc agcagccgca ggccaaccgg ctctccgcaa    11760

ttctggaagc ggtggtcccg gcgcgcgcaa accccacgca cgagaaggtg ctggcgatcg    11820

taaacgcgct ggccgaaaac agggccatcc ggcccgacga ggccggcctg gtctacgacg    11880

cgctgcttca gcgcgtggct cgttacaaca gcggcaacgt gcagaccaac ctggaccggc    11940

tggtggggga tgtgcgcgag gccgtggcgc agcgtgagcg cgcgcagcag cagggcaacc    12000

tgggctccat ggttgcacta aacgccttcc tgagtacaca gcccgccaac gtgccgcggg    12060

gacaggagga ctacaccaac tttgtgagcg cactgcggct aatggtgact gagacaccgc    12120

aaagtgaggt gtaccagtct gggccagact attttttcca gaccagtaga caaggcctgc    12180

agaccgtaaa cctgagccag gctttcaaaa acttgcaggg gctgtggggg gtgcgggctc    12240

ccacaggcga ccgcgcgacc gtgtctagct tgctgacgcc caactcgcgc ctgttgctgc    12300

tgctaatagc gcccttcacg gacagtggca gcgtgtcccg ggacacatac ctaggtcact    12360

tgctgacact gtaccgcgag gccataggtc aggcgcatgt ggacgagcat actttccagg    12420

agattacaag tgtcagccgc gcgctggggc aggaggacac gggcagcctg gaggcaaccc    12480

taaactacct gctgaccaac cggcggcaga agatcccctc gttgcacagt ttaaacagcg    12540

aggaggagcg cattttgcgc tacgtgcagc agagcgtgag ccttaacctg atgcgcgacg    12600

gggtaacgcc cagcgtggcg ctggacatga ccgcgcgcaa catggaaccg ggcatgtatg    12660

cctcaaaccg gccgtttatc aaccgcctaa tggactactt gcatcgcgcg gccgccgtga    12720

accccgagta tttcaccaat gccatcttga acccgcactg gctaccgccc cctggtttct    12780

acaccggggg attcgaggtg cccgagggta acgatggatt cctctgggac gacatagacg    12840

acagcgtgtt ttccccgcaa ccgcagaccc tgctagagtt gcaacagcgc gagcaggcag    12900

aggcggcgct gcgaaaggaa agcttccgca ggccaagcag cttgtccgat ctaggcgctg    12960

cggccccgcg gtcagatgct agtagcccat ttccaagctt gatagggtct cttaccagca    13020

ctcgcaccac ccgcccgcgc ctgctgggcg aggaggagta cctaaacaac tcgctgctgc    13080

agccgcagcg cgaaaaaaac ctgcctccgg catttcccaa caacgggata gagagcctag    13140

tggacaagat gagtagatgg aagacgtacg cgcaggagca cagggacgtg ccaggcccgc    13200

gcccgcccac ccgtcgtcaa aggcacgacc gtcagcgggg tctggtgtgg gaggacgatg    13260

actcggcaga cgacagcagc gtcctggatt tgggagggag tggcaacccg tttgcgcacc    13320

ttcgccccag gctggggaga atgttttaaa aaaaaaaaaa gcatgatgca aaataaaaaa    13380

ctcaccaagg ccatggcacc gagcgttggt tttcttgtat tccccttagt atgcggcgcg    13440

cggcgatgta tgaggaaggt cctcctccct cctacgagag tgtggtgagc gcggcgccag    13500

tggcggcggc gctgggttct cccttcgatg ctcccctgga cccgccgttt gtgcctccgc    13560

ggtacctgcg gcctaccggg gggagaaaca gcatccgtta ctctgagttg gcacccctat    13620

tcgacaccac ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca tccctgaact    13680

accagaacga ccacagcaac tttctgacca cggtcattca aaacaatgac tacagcccgg    13740

gggaggcaag cacacagacc atcaatcttg acgaccggtc gcactggggc ggcgacctga    13800

aaaccatcct gcataccaac atgccaaatg tgaacgagtt catgtttacc aataagttta    13860

aggcgcgggt gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag ctgaaatacg    13920

agtgggtgga gttcacgctg cccgagggca actactccga gaccatgacc atagacctta    13980

tgaacaacgc gatcgtggag cactacttga aagtgggcag acagaacggg gttctggaaa    14040

gcgacatcgg ggtaaagttt gacacccgca acttcagact ggggtttgac cccgtcactg    14100

gtcttgtcat gcctggggta tatacaaacg aagccttcca tccagacatc attttgctgc    14160

caggatgcgg ggtggacttc acccacagcc gcctgagcaa cttgttgggc atccgcaagc    14220

ggcaaccctt ccaggagggc tttaggatca cctacgatga tctggagggt ggtaacattc    14280

ccgcactgtt ggatgtggac gcctaccagg cgagcttgaa agatgacacc gaacagggcg    14340

ggggtggcgc aggcggcagc aacagcagtg gcagcggcgc ggaagagaac tccaacgcgg    14400

cagccgcggc aatgcagccg gtggaggaca tgaacgatca tgccattcgc ggcgacacct    14460

ttgccacacg ggctgaggag aagcgcgctg aggccgaagc agcggccgaa gctgccgccc    14520

ccgctgcgca acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa cccctgacag    14580

aggacagcaa gaaacgcagt tacaacctaa taagcaatga cagcaccttc acccagtacc    14640

gcagctggta ccttgcatac aactacggcg accctcagac cggaatccgc tcatggaccc    14700

tgctttgcac tcctgacgta acctgcggct cggagcaggt ctactggtcg ttgccagaca    14760

tgatgcaaga ccccgtgacc ttccgctcca cgcgccagat cagcaacttt ccggtggtgg    14820

gcgccgagct gttgcccgtg cactccaaga gcttctacaa cgaccaggcc gtctactccc    14880

aactcatccg ccagtttacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga    14940

ttttggcgcg cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt cctgctctca    15000

cagatcacgg gacgctaccg ctgcgcaaca gcatcggagg agtccagcga gtgaccatta    15060

ctgacgccag acgccgcacc tgcccctacg tttacaaggc cctgggcata gtctcgccgc    15120

gcgtcctatc gagccgcact ttttgagcaa gcatgtccat ccttatatcg cccagcaata    15180

acacaggctg gggcctgcgc ttcccaagca agatgtttgg cggggccaag aagcgctccg    15240

accaacaccc agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg cacaaacgcg    15300

gccgcactgg gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag gaggcgcgca    15360

actacacgcc cacgccgcca ccagtgtcca cagtggacgc ggccattcag accgtggtgc    15420

gcggagcccg gcgctatgct aaaatgaaga gacggcggag gcgcgtagca cgtcgccacc    15480

gccgccgacc cggcactgcc gcccaacgcg cggcggcggc cctgcttaac cgcgcacgtc    15540

gcaccggccg acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt attgtcactg    15600

tgccccccag gtccaggcga cgagcggccg ccgcagcagc cgcggccatt agtgctatga    15660

ctcagggtcg caggggcaac gtgtattggg tgcgcgactc ggttagcggc ctgcgcgtgc    15720

ccgtgcgcac ccgccccccg cgcaactaga ttgcaagaaa aaactactta gactcgtact    15780

gttgtatgta tccagcggcg gcggcgcgca acgaagctat gtccaagcgc aaaatcaaag    15840

aagagatgct ccaggtcatc gcgccggaga tctatggccc cccgaagaag gaagagcagg    15900

attacaagcc ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat gatgatgaac    15960

ttgacgacga ggtggaactg ctgcacgcta ccgcgcccag gcgacgggta cagtggaaag    16020

gtcgacgcgt aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg cccggtgagc    16080

gctccacccg cacctacaag cgcgtgtatg atgaggtgta cggcgacgag gacctgcttg    16140

agcaggccaa cgagcgcctc ggggagtttg cctacggaaa gcggcataag gacatgctgg    16200

cgttgccgct ggacgagggc aacccaacac ctagcctaaa gcccgtaaca ctgcagcagg    16260

tgctgcccgc gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag tctggtgact    16320

tggcacccac cgtgcagctg atggtaccca agcgccagcg actggaagat gtcttggaaa    16380

aaatgaccgt ggaacctggg ctggagcccg aggtccgcgt gcggccaatc aagcaggtgg    16440

cgccgggact gggcgtgcag accgtggacg ttcagatacc cactaccagt agcaccagta    16500

ttgccaccgc cacagagggc atggagacac aaacgtcccc ggttgcctca gcggtggcgg    16560

atgccgcggt gcaggcggtc gctgcggccg cgtccaagac ctctacggag gtgcaaacgg    16620

acccgtggat gtttcgcgtt tcagcccccc ggcgcccgcg ccgttcgagg aagtacggcg    16680

ccgccagcgc gctactgccc gaatatgccc tacatccttc cattgcgcct acccccggct    16740

atcgtggcta cacctaccgc cccagaagac gagcaactac ccgacgccga accaccactg    16800

gaacccgccg ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc gtgcgcaggg    16860

tggctcgcga aggaggcagg accctggtgc tgccaacagc gcgctaccac cccagcatcg    16920

tttaaaagcc ggtctttgtg gttcttgcag atatggccct cacctgccgc ctccgtttcc    16980

cggtgccggg attccgagga agaatgcacc gtaggagggg catggccggc cacggcctga    17040

cgggcggcat gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt cgcatgcgcg    17100

gcggtatcct gcccctcctt attccactga tcgccgcggc gattggcgcc gtgcccggaa    17160

ttgcatccgt ggccttgcag gcgcagagac actgattaaa aacaagttgc atgtggaaaa    17220

atcaaaataa aaagtctgga ctctcacgct cgcttggtcc tgtaactatt ttgtagaatg    17280

gaagacatca actttgcgtc tctggccccg cgacacggct cgcgcccgtt catgggaaac    17340

tggcaagata tcggcaccag caatatgagc ggtggcgcct tcagctgggg ctcgctgtgg    17400

agcggcatta aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc ctggaacagc    17460

agcacaggcc agatgctgag ggataagttg aaagagcaaa atttccaaca aaaggtggta    17520

gatggcctgg cctctggcat tagcggggtg gtggacctgg ccaaccaggc agtgcaaaat    17580

aagattaaca gtaagcttga tccccgccct cccgtagagg agcctccacc ggccgtggag    17640

acagtgtctc cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga agaaactctg    17700

gtgacgcaaa tagacgagcc tccctcgtac gaggaggcac taaagcaagg cctgcccacc    17760

acccgtccca tcgcgcccat ggctaccgga gtgctgggcc agcacacacc cgtaacgctg    17820

gacctgcctc cccccgccga cacccagcag aaacctgtgc tgccaggccc gaccgccgtt    17880

gttgtaaccc gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc gcgatcgttg    17940

cggcccgtag ccagtggcaa ctggcaaagc acactgaaca gcatcgtggg tctgggggtg    18000

caatccctga agcgccgacg atgcttctga tagctaacgt gtcgtatgtg tgtcatgtat    18060

gcgtccatgt cgccgccaga ggagctgctg agccgccgcg cgcccgcttt ccaagatggc    18120

taccccttcg atgatgccgc agtggtctta catgcacatc tcgggccagg acgcctcgga    18180

gtacctgagc cccgggctgg tgcagtttgc ccgcgccacc gagacgtact tcagcctgaa    18240

taacaagttt agaaacccca cggtggcgcc tacgcacgac gtgaccacag accggtccca    18300

gcgtttgacg ctgcggttca tccctgtgga ccgtgaggat actgcgtact cgtacaaggc    18360

gcggttcacc ctagctgtgg gtgataaccg tgtgctggac atggcttcca cgtactttga    18420

catccgcggc gtgctggaca ggggccctac ttttaagccc tactctggca ctgcctacaa    18480

cgccctggct cccaagggtg ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct    18540

tgaaataaac ctagaagaag aggacgatga caacgaagac gaagtagacg agcaagctga    18600

gcagcaaaaa actcacgtat ttgggcaggc gccttattct ggtataaata ttacaaagga    18660

gggtattcaa ataggtgtcg aaggtcaaac acctaaatat gccgataaaa catttcaacc    18720

tgaacctcaa ataggagaat ctcagtggta cgaaacagaa attaatcatg cagctgggag    18780

agtcctaaaa aagactaccc caatgaaacc atgttacggt tcatatgcaa aacccacaaa    18840

tgaaaatgga gggcaaggca ttcttgtaaa gcaacaaaat ggaaagctag aaagtcaagt    18900

ggaaatgcaa tttttctcaa ctactgaggc agccgcaggc aatggtgata acttgactcc    18960

taaagtggta ttgtacagtg aagatgtaga tatagaaacc ccagacactc atatttctta    19020

catgcccact attaaggaag gtaactcacg agaactaatg ggccaacaat ctatgcccaa    19080

caggcctaat tacattgctt ttagggacaa ttttattggt ctaatgtatt acaacagcac    19140

gggtaatatg ggtgttctgg cgggccaagc atcgcagttg aatgctgttg tagatttgca    19200

agacagaaac acagagcttt cataccagct tttgcttgat tccattggtg atagaaccag    19260

gtacttttct atgtggaatc aggctgttga cagctatgat ccagatgtta gaattattga    19320

aaatcatgga actgaagatg aacttccaaa ttactgcttt ccactgggag gtgtgattaa    19380

tacagagact cttaccaagg taaaacctaa aacaggtcag gaaaatggat gggaaaaaga    19440

tgctacagaa ttttcagata aaaatgaaat aagagttgga aataattttg ccatggaaat    19500

caatctaaat gccaacctgt ggagaaattt cctgtactcc aacatagcgc tgtatttgcc    19560

cgacaagcta aagtacagtc cttccaacgt aaaaatttct gataacccaa acacctacga    19620

ctacatgaac aagcgagtgg tggctcccgg gctagtggac tgctacatta accttggagc    19680

acgctggtcc cttgactata tggacaacgt caacccattt aaccaccacc gcaatgctgg    19740

cctgcgctac cgctcaatgt tgctgggcaa tggtcgctat gtgcccttcc acatccaggt    19800

gcctcagaag ttctttgcca ttaaaaacct ccttctcctg ccgggctcat acacctacga    19860

gtggaacttc aggaaggatg ttaacatggt tctgcagagc tccctaggaa atgacctaag    19920

ggttgacgga gccagcatta agtttgatag catttgcctt tacgccacct tcttccccat    19980

ggcccacaac accgcctcca cgcttgaggc catgcttaga aacgacacca acgaccagtc    20040

ctttaacgac tatctctccg ccgccaacat gctctaccct atacccgcca acgctaccaa    20100

cgtgcccata tccatcccct cccgcaactg ggcggctttc cgcggctggg ccttcacgcg    20160

ccttaagact aaggaaaccc catcactggg ctcgggctac gacccttatt acacctactc    20220

tggctctata ccctacctag atggaacctt ttacctcaac cacaccttta agaaggtggc    20280

cattaccttt gactcttctg tcagctggcc tggcaatgac cgcctgctta cccccaacga    20340

gtttgaaatt aagcgctcag ttgacgggga gggttacaac gttgcccagt gtaacatgac    20400

caaagactgg ttcctggtac aaatgctagc taactataac attggctacc agggcttcta    20460

tatcccagag agctacaagg accgcatgta ctccttcttt agaaacttcc agcccatgag    20520

ccgtcaggtg gtggatgata ctaaatacaa ggactaccaa caggtgggca tcctacacca    20580

acacaacaac tctggatttg ttggctacct tgcccccacc atgcgcgaag gacaggccta    20640

ccctgctaac ttcccctatc cgcttatagg caagaccgca gttgacagca ttacccagaa    20700

aaagtttctt tgcgatcgca ccctttggcg catcccattc tccagtaact ttatgtccat    20760

gggcgcactc acagacctgg gccaaaacct tctctacgcc aactccgccc acgcgctaga    20820

catgactttt gaggtggatc ccatggacga gcccaccctt ctttatgttt tgtttgaagt    20880

ctttgacgtg gtccgtgtgc accagccgca ccgcggcgtc atcgaaaccg tgtacctgcg    20940

cacgcccttc tcggccggca acgccacaac ataaagaagc aagcaacatc aacaacagct    21000

gccgccatgg gctccagtga gcaggaactg aaagccattg tcaaagatct tggttgtggg    21060

ccatattttt tgggcaccta tgacaagcgc tttccaggct ttgtttctcc acacaagctc    21120

gcctgcgcca tagtcaatac ggccggtcgc gagactgggg gcgtacactg gatggccttt    21180

gcctggaacc cgcactcaaa aacatgctac ctctttgagc cctttggctt ttctgaccag    21240

cgactcaagc aggtttacca gtttgagtac gagtcactcc tgcgccgtag cgccattgct    21300

tcttcccccg accgctgtat aacgctggaa aagtccaccc aaagcgtaca ggggcccaac    21360

tcggccgcct gtggactatt ctgctgcatg tttctccacg cctttgccaa ctggccccaa    21420

actcccatgg atcacaaccc caccatgaac cttattaccg gggtacccaa ctccatgctc    21480

aacagtcccc aggtacagcc caccctgcgt cgcaaccagg aacagctcta cagcttcctg    21540

gagcgccact cgccctactt ccgcagccac agtgcgcaga ttaggagcgc cacttctttt    21600

tgtcacttga aaaacatgta aaaataatgt actagagaca ctttcaataa aggcaaatgc    21660

ttttatttgt acactctcgg gtgattattt acccccaccc ttgccgtctg cgccgtttaa    21720

aaatcaaagg ggttctgccg cgcatcgcta tgcgccactg gcagggacac gttgcgatac    21780

tggtgtttag tgctccactt aaactcaggc acaaccatcc gcggcagctc ggtgaagttt    21840

tcactccaca ggctgcgcac catcaccaac gcgtttagca ggtcgggcgc cgatatcttg    21900

aagtcgcagt tggggcctcc gccctgcgcg cgcgagttgc gatacacagg gttgcagcac    21960

tggaacacta tcagcgccgg gtggtgcacg ctggccagca cgctcttgtc ggagatcaga    22020

tccgcgtcca ggtcctccgc gttgctcagg gcgaacggag tcaactttgg tagctgcctt    22080

cccaaaaagg gcgcgtgccc aggctttgag ttgcactcgc accgtagtgg catcaaaagg    22140

tgaccgtgcc cggtctgggc gttaggatac agcgcctgca taaaagcctt gatctgctta    22200

aaagccacct gagcctttgc gccttcagag aagaacatgc cgcaagactt gccggaaaac    22260

tgattggccg gacaggccgc gtcgtgcacg cagcaccttg cgtcggtgtt ggagatctgc    22320

accacatttc ggccccaccg gttcttcacg atcttggcct tgctagactg ctccttcagc    22380

gcgcgctgcc cgttttcgct cgtcacatcc atttcaatca cgtgctcctt atttatcata    22440

atgcttccgt gtagacactt aagctcgcct tcgatctcag cgcagcggtg cagccacaac    22500

gcgcagcccg tgggctcgtg atgcttgtag gtcacctctg caaacgactg caggtacgcc    22560

tgcaggaatc gccccatcat cgtcacaaag gtcttgttgc tggtgaaggt cagctgcaac    22620

ccgcggtgct cctcgttcag ccaggtcttg catacggccg ccagagcttc cacttggtca    22680

ggcagtagtt tgaagttcgc ctttagatcg ttatccacgt ggtacttgtc catcagcgcg    22740

cgcgcagcct ccatgccctt ctcccacgca gacacgatcg gcacactcag cgggttcatc    22800

accgtaattt cactttccgc ttcgctgggc tcttcctctt cctcttgcgt ccgcatacca    22860

cgcgccactg ggtcgtcttc attcagccgc cgcactgtgc gcttacctcc tttgccatgc    22920

ttgattagca ccggtgggtt gctgaaaccc accatttgta gcgccacatc ttctctttct    22980

tcctcgctgt ccacgattac ctctggtgat ggcgggcgct cgggcttggg agaagggcgc    23040

ttctttttct tcttgggcgc aatggccaaa tccgccgccg aggtcgatgg ccgcgggctg    23100

ggtgtgcgcg gcaccagcgc gtcttgtgat gagtcttcct cgtcctcgga ctcgatacgc    23160

cgcctcatcc gcttttttgg gggcgcccgg ggaggcggcg gcgacgggga cggggacgac    23220

acgtcctcca tggttggggg acgtcgcgcc gcaccgcgtc cgcgctcggg ggtggtttcg    23280

cgctgctcct cttcccgact ggccatttcc ttctcctata ggcagaaaaa gatcatggag    23340

tcagtcgaga agaaggacag cctaaccgcc ccctctgagt tcgccaccac cgcctccacc    23400

gatgccgcca acgcgcctac caccttcccc gtcgaggcac ccccgcttga ggaggaggaa    23460

gtgattatcg agcaggaccc aggttttgta agcgaagacg acgaggaccg ctcagtacca    23520

acagaggata aaaagcaaga ccaggacaac gcagaggcaa acgaggaaca agtcgggcgg    23580

ggggacgaaa ggcatggcga ctacctagat gtgggagacg acgtgctgtt gaagcatctg    23640

cagcgccagt gcgccattat ctgcgacgcg ttgcaagagc gcagcgatgt gcccctcgcc    23700

atagcggatg tcagccttgc ctacgaacgc cacctattct caccgcgcgt accccccaaa    23760

cgccaagaaa acggcacatg cgagcccaac ccgcgcctca acttctaccc cgtatttgcc    23820

gtgccagagg tgcttgccac ctatcacatc tttttccaaa actgcaagat acccctatcc    23880

tgccgtgcca accgcagccg agcggacaag cagctggcct tgcggcaggg cgctgtcata    23940

cctgatatcg cctcgctcaa cgaagtgcca aaaatctttg agggtcttgg acgcgacgag    24000

aagcgcgcgg caaacgctct gcaacaggaa aacagcgaaa atgaaagtca ctctggagtg    24060

ttggtggaac tcgagggtga caacgcgcgc ctagccgtac taaaacgcag catcgaggtc    24120

acccactttg cctacccggc acttaaccta ccccccaagg tcatgagcac agtcatgagt    24180

gagctgatcg tgcgccgtgc gcagcccctg gagagggatg caaatttgca agaacaaaca    24240

gaggagggcc tacccgcagt tggcgacgag cagctagcgc gctggcttca aacgcgcgag    24300

cctgccgact tggaggagcg acgcaaacta atgatggccg cagtgctcgt taccgtggag    24360

cttgagtgca tgcagcggtt ctttgctgac ccggagatgc agcgcaagct agaggaaaca    24420

ttgcactaca cctttcgaca gggctacgta cgccaggcct gcaagatctc caacgtggag    24480

ctctgcaacc tggtctccta ccttggaatt ttgcacgaaa accgccttgg gcaaaacgtg    24540

cttcattcca cgctcaaggg cgaggcgcgc cgcgactacg tccgcgactg cgtttactta    24600

tttctatgct acacctggca gacggccatg ggcgtttggc agcagtgctt ggaggagtgc    24660

aacctcaagg agctgcagaa actgctaaag caaaacttga aggacctatg gacggccttc    24720

aacgagcgct ccgtggccgc gcacctggcg gacatcattt tccccgaacg cctgcttaaa    24780

accctgcaac agggtctgcc agacttcacc agtcaaagca tgttgcagaa ctttaggaac    24840

tttatcctag agcgctcagg aatcttgccc gccacctgct gtgcacttcc tagcgacttt    24900

gtgcccatta agtaccgcga atgccctccg ccgctttggg gccactgcta ccttctgcag    24960

ctagccaact accttgccta ccactctgac ataatggaag acgtgagcgg tgacggtcta    25020

ctggagtgtc actgtcgctg caacctatgc accccgcacc gctccctggt ttgcaattcg    25080

cagctgctta acgaaagtca aattatcggt acctttgagc tgcagggtcc ctcgcctgac    25140

gaaaagtccg cggctccggg gttgaaactc actccggggc tgtggacgtc ggcttacctt    25200

cgcaaatttg tacctgagga ctaccacgcc cacgagatta ggttctacga agaccaatcc    25260

cgcccgccta atgcggagct taccgcctgc gtcattaccc agggccacat tcttggccaa    25320

ttgcaagcca tcaacaaagc ccgccaagag tttctgctac gaaagggacg gggggtttac    25380

ttggaccccc agtccggcga ggagctcaac ccaatccccc cgccgccgca gccctatcag    25440

cagcagccgc gggcccttgc ttcccaggat ggcacccaaa aagaagctgc agctgccgcc    25500

gccacccacg gacgaggagg aatactggga cagtcaggca gaggaggttt tggacgagga    25560

ggaggaggac atgatggaag actgggagag cctagacgag gaagcttccg aggtcgaaga    25620

ggtgtcagac gaaacaccgt caccctcggt cgcattcccc tcgccggcgc cccagaaatc    25680

ggcaaccggt tccagcatgg ctacaacctc cgctcctcag gcgccgccgg cactgcccgt    25740

tcgccgaccc aaccgtagat gggacaccac tggaaccagg gccggtaagt ccaagcagcc    25800

gccgccgtta gcccaagagc aacaacagcg ccaaggctac cgctcatggc gcgggcacaa    25860

gaacgccata gttgcttgct tgcaagactg tgggggcaac atctccttcg cccgccgctt    25920

tcttctctac catcacggcg tggccttccc ccgtaacatc ctgcattact accgtcatct    25980

ctacagccca tactgcaccg gcggcagcgg cagcaacagc agcggccaca cagaagcaaa    26040

ggcgaccgga tagcaagact ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag    26100

gaggaggagc gctgcgtctg gcgcccaacg aacccgtatc gacccgcgag cttagaaaca    26160

ggatttttcc cactctgtat gctatatttc aacagagcag gggccaagaa caagagctga    26220

aaataaaaaa caggtctctg cgatccctca cccgcagctg cctgtatcac aaaagcgaag    26280

atcagcttcg gcgcacgctg gaagacgcgg aggctctctt cagtaaatac tgcgcgctga    26340

ctcttaagga ctagtttcgc gccctttctc aaatttaagc gcgaaaacta cgtcatctcc    26400

agcggccaca cccggcgcca gcacctgttg tcagcgccat tatgagcaag gaaattccca    26460

cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact    26520

actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa    26580

tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta    26640

ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca    26700

ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc    26760

agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga    26820

caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc    26880

gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg    26940

caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc    27000

aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc    27060

actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg    27120

actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc    27180

gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc    27240

atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc    27300

tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc    27360

tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct    27420

gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta    27480

aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac    27540

atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac    27600

ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt    27660

acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc    27720

cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg    27780

gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg    27840

ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct    27900

ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg    27960

catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc    28020

ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag    28080

ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc    28140

accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt    28200

tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa    28260

agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac    28320

atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc    28380

tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa    28440

tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa    28500

agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc    28560

attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg    28620

aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg    28680

atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag    28740

cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca    28800

tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg    28860

tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc    28920

ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac    28980

aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga    29040

ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg ctttttttgt    29100

gcgtgctcca cattggctgc ggtttctcac atcgaagtag actgcattcc agccttcaca    29160

gtctatttgc tttacggatt tgtcaccctc acgctcatct gcagcctcat cactgtggtc    29220

atcgccttta tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct cagacaccat    29280

ccccagtaca gggacaggac tatagctgag cttcttagaa ttctttaatt atgaaattta    29340

ctgtgacttt tctgctgatt atttgcaccc tatctgcgtt ttgttccccg acctccaagc    29400

ctcaaagaca tatatcatgc agattcactc gtatatggaa tattccaagt tgctacaatg    29460

aaaaaagcga tctttccgaa gcctggttat atgcaatcat ctctgttatg gtgttctgca    29520

gtaccatctt agccctagct atatatccct accttgacat tggctggaac gcaatagatg    29580

ccatgaacca cccaactttc cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg    29640

gcggctttgt cccagccaat cagcctcgcc caccttctcc cacccccact gaaatcagct    29700

actttaatct aacaggagga gatgactgac accctagatc tagaaatgga cggaattatt    29760

acagagcagc gcctgctaga aagacgcagg gcagcggccg agcaacagcg catgaatcaa    29820

gagctccaag acatggttaa cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag    29880

caggccaaag tcacctacga cagtaatacc accggacacc gccttagcta caagttgcca    29940

accaagcgtc agaaattggt ggtcatggtg ggagaaaagc ccattaccat aactcagcac    30000

tcggtagaaa ccgaaggctg cattcactca ccttgtcaag gacctgagga tctctgcacc    30060

cttattaaga ccctgtgcgg tctcaaagat cttattccct ttaactaata aaaaaaaata    30120

ataaagcatc acttacttaa aatcagttag caaatttctg tccagtttat tcagcagcac    30180

ctccttgccc tcctcccagc tctggtattg cagcttcctc ctggctgcaa actttctcca    30240

caatctaaat ggaatgtcag tttcctcctg ttcctgtcca tccgcaccca ctatcttcat    30300

gttgttgcag atgaagcgcg caagaccgtc tgaagatacc ttcaaccccg tgtatccata    30360

tgacacggaa accggtcctc caactgtgcc ttttcttact cctccctttg tatcccccaa    30420

tgggtttcaa gagagtcccc ctggggtact ctctttgcgc ctatccgaac ctctagttac    30480

ctccaatggc atgcttgcgc tcaaaatggg caacggcctc tctctggacg aggccggcaa    30540

ccttacctcc caaaatgtaa ccactgtgag cccacctctc aaaaaaacca agtcaaacat    30600

aaacctggaa atatctgcac ccctcacagt tacctcagaa gccctaactg tggctgccgc    30660

cgcacctcta atggtcgcgg gcaacacact caccatgcaa tcacaggccc cgctaaccgt    30720

gcacgactcc aaacttagca ttgccaccca aggacccctc acagtgtcag aaggaaagct    30780

agccctgcaa acatcaggcc ccctcaccac caccgatagc agtaccctta ctatcactgc    30840

ctcaccccct ctaactactg ccactggtag cttgggcatt gacttgaaag agcccattta    30900

tacacaaaat ggaaaactag gactaaagta cggggctcct ttgcatgtaa cagacgacct    30960

aaacactttg accgtagcaa ctggtccagg tgtgactatt aataatactt ccttgcaaac    31020

taaagttact ggagccttgg gttttgattc acaaggcaat atgcaactta atgtagcagg    31080

aggactaagg attgattctc aaaacagacg ccttatactt gatgttagtt atccgtttga    31140

tgctcaaaac caactaaatc taagactagg acagggccct ctttttataa actcagccca    31200

caacttggat attaactaca acaaaggcct ttacttgttt acagcttcaa acaattccaa    31260

aaagcttgag gttaacctaa gcactgccaa ggggttgatg tttgacgcta cagccatagc    31320

cattaatgca ggagatgggc ttgaatttgg ttcacctaat gcaccaaaca caaatcccct    31380

caaaacaaaa attggccatg gcctagaatt tgattcaaac aaggctatgg ttcctaaact    31440

aggaactggc cttagttttg acagcacagg tgccattaca gtaggaaaca aaaataatga    31500

taagctaact ttgtggacca caccagctcc atctcctaac tgtagactaa atgcagagaa    31560

agatgctaaa ctcactttgg tcttaacaaa atgtggcagt caaatacttg ctacagtttc    31620

agttttggct gttaaaggca gtttggctcc aatatctgga acagttcaaa gtgctcatct    31680

tattataaga tttgacgaaa atggagtgct actaaacaat tccttcctgg acccagaata    31740

ttggaacttt agaaatggag atcttactga aggcacagcc tatacaaacg ctgttggatt    31800

tatgcctaac ctatcagctt atccaaaatc tcacggtaaa actgccaaaa gtaacattgt    31860

cagtcaagtt tacttaaacg gagacaaaac taaacctgta acactaacca ttacactaaa    31920

cggtacacag gaaacaggag acacaactcc aagtgcatac tctatgtcat tttcatggga    31980

ctggtctggc cacaactaca ttaatgaaat atttgccaca tcctcttaca ctttttcata    32040

cattgcccaa gaataaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc    32100

agaaaatttc aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca    32160

gatcaccgta ccttaatcaa actcacagaa ccctagtatt caacctgcca cctccctccc    32220

aacacacaga gtacacagtc ctttctcccc ggctggcctt aaaaagcatc atatcatggg    32280

taacagacat attcttaggt gttatattcc acacggtttc ctgtcgagcc aaacgctcat    32340

cagtgatatt aataaactcc ccgggcagct cacttaagtt catgtcgctg tccagctgct    32400

gagccacagg ctgctgtcca acttgcggtt gcttaacggg cggcgaagga gaagtccacg    32460

cctacatggg ggtagagtca taatcgtgca tcaggatagg gcggtggtgc tgcagcagcg    32520

cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga atacaacatg gcagtggtct    32580

cctcagcgat gattcgcacc gcccgcagca taaggcgcct tgtcctccgg gcacagcagc    32640

gcaccctgat ctcacttaaa tcagcacagt aactgcagca cagcaccaca atattgttca    32700

aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca gaacccacgt    32760

ggccatcata ccacaagcgc aggtagatta agtggcgacc cctcataaac acgctggaca    32820

taaacattac ctcttttggc atgttgtaat tcaccacctc ccggtaccat ataaacctct    32880

gattaaacat ggcgccatcc accaccatcc taaaccagct ggccaaaacc tgcccgccgg    32940

ctatacactg cagggaaccg ggactggaac aatgacagtg gagagcccag gactcgtaac    33000

catggatcat catgctcgtc atgatatcaa tgttggcaca acacaggcac acgtgcatac    33060

acttcctcag gattacaagc tcctcccgcg ttagaaccat atcccaggga acaacccatt    33120

cctgaatcag cgtaaatccc acactgcagg gaagacctcg cacgtaactc acgttgtgca    33180

ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc cagtatggta gcgcgggttt    33240

ctgtctcaaa aggaggtaga cgatccctac tgtacggagt gcgccgagac aaccgagatc    33300

gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt agtcatattt cctgaagcaa    33360

aaccaggtgc gggcgtgaca aacagatctg cgtctccggt ctcgccgctt agatcgctct    33420

gtgtagtagt tgtagtatat ccactctctc aaagcatcca ggcgccccct ggcttcgggt    33480

tctatgtaaa ctccttcatg cgccgctgcc ctgataacat ccaccaccgc agaataagcc    33540

acacccagcc aacctacaca ttcgttctgc gagtcacaca cgggaggagc gggaagagct    33600

ggaagaacca tgtttttttt tttattccaa aagattatcc aaaacctcaa aatgaagatc    33660

tattaagtga acgcgctccc ctccggtggc gtggtcaaac tctacagcca aagaacagat    33720

aatggcattt gtaagatgtt gcacaatggc ttccaaaagg caaacggccc tcacgtccaa    33780

gtggacgtaa aggctaaacc cttcagggtg aatctcctct ataaacattc cagcaccttc    33840

aaccatgccc aaataattct catctcgcca ccttctcaat atatctctaa gcaaatcccg    33900

aatattaagt ccggccattg taaaaatctg ctccagagcg ccctccacct tcagcctcaa    33960

gcagcgaatc atgattgcaa aaattcaggt tcctcacaga cctgtataag attcaaaagc    34020

ggaacattaa caaaaatacc gcgatcccgt aggtcccttc gcagggccag ctgaacataa    34080

tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc caggaaccat gacaaaagaa    34140

cccacactga ttatgacacg catactcgga gctatgctaa ccagcgtagc cccgatgtaa    34200

gcttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc aggcaaagcc    34260

tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaaggca ggtaagctcc    34320

ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg tttctgcata    34380

aacacaaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt acaacaggaa    34440

aaacaaccct tataagcata agacggacta cggccatgcc ggcgtgaccg taaaaaaact    34500

ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga gtcataatgt    34560

aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag cgaccgaaat    34620

agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc ataggaggta    34680

taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc tgcctaggca    34740

aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca gccataacag    34800

tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca cggcaccagc    34860

tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg agtatatata ggactaaaaa    34920

atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga acctacgccc    34980

agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt ttcccacgtt    35040

acgtcacttc ccattttaag aaaactacaa ttcccaacac atacaagtta ctccgcccta    35100

aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact ccaccccctc    35160

attatcatat tggcttcaat ccaaaataag gtatattatt gatgatg                  35207


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  20
ggtgactttg cttctggag                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  21
ctccagaagc aaagtcacc                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  22
gtacttcata cttttcatt                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cis-regulatory element

<400>  23
aatgaaaagt atgaagtac                                                    19


<210>  24
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hypoxia Response element

<400>  24
gcacgt                                                                   6


<210>  25
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  25

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40  


