                               SEQUENCE LISTING

<110> MiNA Therapeutics Limited
      Andrikakou, Pinelopi
      Debacker, Alexandre
      Reebye, Vikash
 
<120> SIRT1-SARNA COMPOSITIONS AND METHODS OF USE

<130> 2058.1028PCT

<150> PCT/EPXX/XXXXXX
<151> 2020-04-09

<150> US 62/833,033
<151> 2019-04-12

<140> US 63/000,775
<141> 2020-03-27

<160> 118   

<170> PatentIn version 3.5

<210> 1
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 1
cagaaaagat agccgggagc ggtggctcac gcctctaatt ccagagcttt gggaggccga       60

ggcaggcgga tcacctgagg ttgagaattc gagaccagcc tgaccaacat ggagaaatct      120

cgtctctact aataatacaa aaattagccg ggcatggtgg cgcatgcctg taatcccaac      180

tactcaggag gctgaggcac gagaatggct tgaacccggg aagcggaggt tgcggtgagc      240

cgagatcacg ccattgcact ccagcttggg taacaagagc gaaactccac cttttaaaaa      300

aaaagaaaag gaaaaaaaaa aagaaaagat aataatctag ctagaatgta tcatacaatc      360

acaaacaata gcgttcgtga aacgtgtaat aaatggacat ttacataaaa acgtcattca      420

aatataacct tggcaatgcg cacgttaaac ttacacaata ctacaagtac ctctgcattg      480

tttcctctat taaataaaca gtattaataa cacaattatt attaggtaaa taataaatta      540

gtactcaact gtgttgcttg aaatcagggt ctctttacta aatcagtccc taaaaacaca      600

tattactttt tttttttttt ttttttgaga cggggtctca ctctgttgcc caccctggag      660

tgcagtggca ggatcacagc tcactgcaac ctcgaactct agtacctggg actaaaggtg      720

tgcgacacca cgtcccgctt tttttacttt tagtagagag gaggtctcgc tatgttgccc      780

aggctggcct gaaactccta ggctcaagag atcctcccgc tttggcctcc caaagtgcta      840

ggattacacg aaagagccac cgcgcccggc ctgacccaaa tattgataaa gatgaacacc      900

tatcaaggat agaaactcct cagatcaaaa ataagaaacc tgaccgggcg cggtggctca      960

cgcctgtaat cccagcactt tgggcggccg aggcggacgg atcacgaagt caagaaatca     1020

agaccatcct ggccaacatg gtgaaacccc gtctctgcta aaaacacaaa aattagctgg     1080

gcgtggtggc gggtgtctgt agtcccagct actcggcagg ctgaaggaga atcggttgaa     1140

cgcgggaggc ggaggttgca ctgagccgag atcgcgccac tgcactccag cctagcgaca     1200

gagcgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa gaaaccttca agaacatgac     1260

aactgcaaca tatctgcttc attatgctag aagtgttaag tttgtgtctc aatactacat     1320

acatacaaaa aaagcatgtt tagcccaaac accattaccg cacaagagca agattagaat     1380

aaaagtaata tgaacagctc taaaagtact ctctctccca tacccactcc taactgcatt     1440

acagaatggt aatgtcttca ggaacagcca cgttctttaa attttgcaag ctgtgactat     1500

agaaacagct ttcctctttc aaaaattgta atttcagtca taaaaatata gaccaaaaaa     1560

agcaaactgc acaggtgtca agtttgcaaa aagcaattga aaacgcagac caacgggaca     1620

gccaaaaagt tgcagactta agtgtgctgg ggggtagagg agaaaagcaa tgaaaataaa     1680

aaataaagaa aaagaaaaaa aaagctctaa caaaagcaat atgctaaaag agtaagaggg     1740

ggagagaaac ttattttaaa gcgactgcga gagtctcccg acctggctgc tgcggaaaga     1800

acaaggccgc ccaggcgggc cacggacgga ggaaaagagc gaatccactg gcagctcgcg     1860

cagtaggaac cgcagccccg gaggagcgcg gctgaacgga gggccggggt ggggagggga     1920

acgccgcgga gcctgccccg agcccccagc cgccctcaac ctcaggccag taggagcccg     1980

gggagaggga ggaggagatg cgcagttccg gccgcccgca ccctgcgcac ctcggtaccc     2040

aatcgccgcc gccgccgcct cttcctcctc ctcgccctcg tcgtcgtcgt cttcgtcgta     2100

caagttgtcg gccagcggtg gctcccgaga tgggccctgc aggcccggcc cattgtctcc     2160

ttccccagcc gccgcagtcg cctgggcctc ttgctccccg cctgccgccg ccgcctctgc     2220

ctccgcctcc cgccacagcg ccgccgccgc cgcacccggg cagcccctgg ccgccgccgg     2280

cacctcacgc tctggggccg ccccaccggg ctcgcccggg ctccgctcga ggccgggacc     2340

atctctccgc ggcctcttgc ggagcggctc cccggcgggg gacgacgcgg cctccctgtc     2400

ggcccccgcc gccgaggggg agccgccggg ctgaagggcg agggccgcct cgtccgccat     2460

cttccaactg cctctctggc cctcctccct cgcctcctct gctcccgctc gacgcgcggc     2520

actggcgccc ccgcggctcc ggctgcggga gatttaaacc ccatcacgtg acccgcccca     2580

tcgccgcccc cgccctctcg gcgctcccgc cacccacgcg ggccagacca caacactacg     2640

ggtcacgtgg cgggcggagg ctgttgcgtc taccgctccg cctgggctgg aagcgcactc     2700

ggccccggcg gccggcggcc cttcctcttt gtggcgagcg tgtagtgcag ccaaattcgc     2760

ccctcggccg ctttctcaac ttctctttca aactgacctc aaatcactac cgccggaaca     2820

gctcaagttt tggtccgccc tgggaatttc cacgtcttcc tgaagtgtac acctggcctg     2880

ccttagcctt gtctatattt agctaagggt taaaacacag ctgaagctgg ctaagactta     2940

gctccctgaa atacgttgga tagtcgttct gttttgttaa taagtaggaa gagaggcaaa     3000

aggaggcggc tcctttccca ctctcctcac accgttctga cagctcctct tttgctcctt     3060

tttctgctcc ttgcttttct ccttagtcgg ttgctttttt cccctctctc ccatcacttg     3120

tagggtggta tacattgtaa aatccttgaa ggcatatgtc ctcctgggaa gacctttgac     3180

gtggaggttt ggagatcagc cgatctactt tctggcccca gcttggcttc aaacgtgtgt     3240

gaattccctc ctccgggcct cagttttctc acgtgcagaa tgggtttgtt gggtcagtat     3300

gagagcatgg gaaggaaatg acttggcctc catgcacatc tgcccttggt taaaatttgg     3360

agtccttcct ttctagcgtg agctatctag ccgtttctaa acttaatttt tctcatgtct     3420

taaatggtaa taagtatttt aaaacgtcat agatttaaat gagataacca gatgtaaaac     3480

gaggggtacc tagtagttca aaaggcttag tggaaagccc ttccactttc ctctctccct     3540

gaaattctgg cacactgtga ctccatatct aatcttaact aaggacccat ataacccatg     3600

gtagatctag agccagtgtt tgttatggca tctgcctgga gcacagcgtt tctatctgtt     3660

taaaggacct ctacgagttt atggtacact gtcccttaag cctagtatgg gttctggcca     3720

tactgcatca attacctgcg tgactttagg caaccaactt aaagctgttt cttcatcctt     3780

aaaataaaaa ataaaaagct ggaaatatat cgctaaggtc ctatctacat ccaaaagtct     3840

tatttcatct ggtcaccact attcatttct gaaagtaatc atctccagtc ctagaagcct     3900

taaaaccatc tttggttgcg tgggggtcaa ggggagggag agcattagga caaatagcta     3960

atgcatgcgg gacttaaaac ctggctgggc gcggtggctg c                         4001


<210> 2
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 2
caattattat taggtaaata ataaattagt actcaactgt gttgcttgaa atcagggtct       60

ctttactaaa tcagtcccta aaaacacata ttactttttt tttttttttt ttttgagacg      120

gggtctcact ctgttgccca ccctggagtg cagtggcagg atcacagctc actgcaacct      180

cgaactctag tacctgggac taaaggtgtg cgacaccacg tcccgctttt tttactttta      240

gtagagagga ggtctcgcta tgttgcccag gctggcctga aactcctagg ctcaagagat      300

cctcccgctt tggcctccca aagtgctagg attacacgaa agagccaccg cgcccggcct      360

gacccaaata ttgataaaga tgaacaccta tcaaggatag aaactcctca gatcaaaaat      420

aagaaacctg accgggcgcg gtggctcacg cctgtaatcc cagcactttg ggcggccgag      480

gcggacggat cacgaagtca agaaatcaag accatcctgg ccaacatggt gaaaccccgt      540

ctctgctaaa aacacaaaaa ttagctgggc gtggtggcgg gtgtctgtag tcccagctac      600

tcggcaggct gaaggagaat cggttgaacg cgggaggcgg aggttgcact gagccgagat      660

cgcgccactg cactccagcc tagcgacaga gcgagactcc gtctcaaaaa aaaaaaaaaa      720

aaaaaaaaga aaccttcaag aacatgacaa ctgcaacata tctgcttcat tatgctagaa      780

gtgttaagtt tgtgtctcaa tactacatac atacaaaaaa agcatgttta gcccaaacac      840

cattaccgca caagagcaag attagaataa aagtaatatg aacagctcta aaagtactct      900

ctctcccata cccactccta actgcattac agaatggtaa tgtcttcagg aacagccacg      960

ttctttaaat tttgcaagct gtgactatag aaacagcttt cctctttcaa aaattgtaat     1020

ttcagtcata aaaatataga ccaaaaaaag caaactgcac aggtgtcaag tttgcaaaaa     1080

gcaattgaaa acgcagacca acgggacagc caaaaagttg cagacttaag tgtgctgggg     1140

ggtagaggag aaaagcaatg aaaataaaaa ataaagaaaa agaaaaaaaa agctctaaca     1200

aaagcaatat gctaaaagag taagaggggg agagaaactt attttaaagc gactgcgaga     1260

gtctcccgac ctggctgctg cggaaagaac aaggccgccc aggcgggcca cggacggagg     1320

aaaagagcga atccactggc agctcgcgca gtaggaaccg cagccccgga ggagcgcggc     1380

tgaacggagg gccggggtgg ggaggggaac gccgcggagc ctgccccgag cccccagccg     1440

ccctcaacct caggccagta ggagcccggg gagagggagg aggagatgcg cagttccggc     1500

cgcccgcacc ctgcgcacct cggtacccaa tcgccgccgc cgccgcctct tcctcctcct     1560

cgccctcgtc gtcgtcgtct tcgtcgtaca agttgtcggc cagcggtggc tcccgagatg     1620

ggccctgcag gcccggccca ttgtctcctt ccccagccgc cgcagtcgcc tgggcctctt     1680

gctccccgcc tgccgccgcc gcctctgcct ccgcctcccg ccacagcgcc gccgccgccg     1740

cacccgggca gcccctggcc gccgccggca cctcacgctc tggggccgcc ccaccgggct     1800

cgcccgggct ccgctcgagg ccgggaccat ctctccgcgg cctcttgcgg agcggctccc     1860

cggcggggga cgacgcggcc tccctgtcgg cccccgccgc cgagggggag ccgccgggct     1920

gaagggcgag ggccgcctcg tccgccatct tccaactgcc tctctggccc tcctccctcg     1980

cctcctctgc tcccgctcga cgcgcggcac tggcgccccc gcggctccgg ctgcgggaga     2040

tttaaacccc atcacgtgac ccgccccatc gccgcccccg ccctctcggc gctcccgcca     2100

cccacgcggg ccagaccaca acactacggg tcacgtggcg ggcggaggct gttgcgtcta     2160

ccgctccgcc tgggctggaa gcgcactcgg ccccggcggc cggcggccct tcctctttgt     2220

ggcgagcgtg tagtgcagcc aaattcgccc ctcggccgct ttctcaactt ctctttcaaa     2280

ctgacctcaa atcactaccg ccggaacagc tcaagttttg gtccgccctg ggaatttcca     2340

cgtcttcctg aagtgtacac ctggcctgcc ttagccttgt ctatatttag ctaagggtta     2400

aaacacagct gaagctggct aagacttagc tccctgaaat acgttggata gtcgttctgt     2460

tttgttaata agtaggaaga gaggcaaaag gaggcggctc ctttcccact ctcctcacac     2520

cgttctgaca gctcctcttt tgctcctttt tctgctcctt gcttttctcc ttagtcggtt     2580

gcttttttcc cctctctccc atcacttgta gggtggtata cattgtaaaa tccttgaagg     2640

catatgtcct cctgggaaga cctttgacgt ggaggtttgg agatcagccg atctactttc     2700

tggccccagc ttggcttcaa acgtgtgtga attccctcct ccgggcctca gttttctcac     2760

gtgcagaatg ggtttgttgg gtcagtatga gagcatggga aggaaatgac ttggcctcca     2820

tgcacatctg cccttggtta aaatttggag tccttccttt ctagcgtgag ctatctagcc     2880

gtttctaaac ttaatttttc tcatgtctta aatggtaata agtattttaa aacgtcatag     2940

atttaaatga gataaccaga tgtaaaacga ggggtaccta gtagttcaaa aggcttagtg     3000

gaaagccctt ccactttcct ctctccctga aattctggca cactgtgact ccatatctaa     3060

tcttaactaa ggacccatat aacccatggt agatctagag ccagtgtttg ttatggcatc     3120

tgcctggagc acagcgtttc tatctgttta aaggacctct acgagtttat ggtacactgt     3180

cccttaagcc tagtatgggt tctggccata ctgcatcaat tacctgcgtg actttaggca     3240

accaacttaa agctgtttct tcatccttaa aataaaaaat aaaaagctgg aaatatatcg     3300

ctaaggtcct atctacatcc aaaagtctta tttcatctgg tcaccactat tcatttctga     3360

aagtaatcat ctccagtcct agaagcctta aaaccatctt tggttgcgtg ggggtcaagg     3420

ggagggagag cattaggaca aatagctaat gcatgcggga cttaaaacct ggctgggcgc     3480

ggtggctgct gcctgtaatc ccagcacttt gggaggccga ggcggacaga tcacctgaag     3540

tcggaagttc gagaccagcc tgaccaacat ggagaaaccc cgtctctact aaaaatacaa     3600

aattagccgg gcgtggtggc acatgcctgt aatcccagct actcagaagg ctgaggcagg     3660

agaatcgctt gaacccagca ggcagaggtt gcggtgagcc gagatcgcac cattgcacac     3720

cagcctgggc agcaagagcg aaactccgtc tcaaaaaaaa atataaataa aacctagatg     3780

aggggttgat tggtgcagca aaccaccatg gctcacctat aagtatgtaa caaacctaca     3840

cattctgcac ctgtatcctg gaacttaaat taaaaaaaaa atctttgaag cgttccttca     3900

taccaatccc tctgaaatcc atctgaccaa tcaatgacca aatcctgttg tccttccttt     3960

cttgctacac tcctcccaat tcctgactag gcaccacact c                         4001


<210> 3
<211> 19
<212> DNA
<213> Homo sapiens

<400> 3
gacttagctc cctgaaata                                                    19


<210> 4
<211> 19
<212> DNA
<213> Homo sapiens

<400> 4
gccttagcct tgtctatat                                                    19


<210> 5
<211> 19
<212> DNA
<213> Homo sapiens

<400> 5
agacttagct ccctgaaat                                                    19


<210> 6
<211> 19
<212> DNA
<213> Homo sapiens

<400> 6
cgtgtagtgc agccaaatt                                                    19


<210> 7
<211> 19
<212> DNA
<213> Homo sapiens

<400> 7
tcgtcttcgt cgtacaagt                                                    19


<210> 8
<211> 19
<212> DNA
<213> Homo sapiens

<400> 8
atatgtcctc ctgggaaga                                                    19


<210> 9
<211> 19
<212> DNA
<213> Homo sapiens

<400> 9
gccggaacag ctcaagttt                                                    19


<210> 10
<211> 19
<212> DNA
<213> Homo sapiens

<400> 10
tttctatctg tttaaagga                                                    19


<210> 11
<211> 19
<212> DNA
<213> Homo sapiens

<400> 11
ccatataacc catggtaga                                                    19


<210> 12
<211> 19
<212> DNA
<213> Homo sapiens

<400> 12
gcttcaaacg tgtgtgaat                                                    19


<210> 13
<211> 19
<212> DNA
<213> Homo sapiens

<400> 13
agccgtttct aaacttaat                                                    19


<210> 14
<211> 19
<212> DNA
<213> Homo sapiens

<400> 14
ctgaaatacg ttggatagt                                                    19


<210> 15
<211> 19
<212> DNA
<213> Homo sapiens

<400> 15
gttggatagt cgttctgtt                                                    19


<210> 16
<211> 19
<212> DNA
<213> Homo sapiens

<400> 16
tgccttagcc ttgtctata                                                    19


<210> 17
<211> 19
<212> DNA
<213> Homo sapiens

<400> 17
ctagccgttt ctaaactta                                                    19


<210> 18
<211> 19
<212> DNA
<213> Homo sapiens

<400> 18
gcaagctgtg actatagaa                                                    19


<210> 19
<211> 19
<212> DNA
<213> Homo sapiens

<400> 19
gtgttaagtt tgtgtctca                                                    19


<210> 20
<211> 19
<212> DNA
<213> Homo sapiens

<400> 20
tgctagaagt gttaagttt                                                    19


<210> 21
<211> 19
<212> DNA
<213> Homo sapiens

<400> 21
cagccacgtt ctttaaatt                                                    19


<210> 22
<211> 19
<212> DNA
<213> Homo sapiens

<400> 22
aagtttgtgt ctcaatact                                                    19


<210> 23
<211> 19
<212> DNA
<213> Homo sapiens

<400> 23
agagcaagat tagaataaa                                                    19


<210> 24
<211> 19
<212> DNA
<213> Homo sapiens

<400> 24
tgcattacag aatggtaat                                                    19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gacuuagcuc ccugaaaua                                                    19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gccuuagccu ugucuauau                                                    19


<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
agacuuagcu cccugaaau                                                    19


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
cguguagugc agccaaauu                                                    19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ucgucuucgu cguacaagu                                                    19


<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
auauguccuc cugggaaga                                                    19


<210> 31
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gccggaacag cucaaguuu                                                    19


<210> 32
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
uuucuaucug uuuaaagga                                                    19


<210> 33
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
ccauauaacc caugguaga                                                    19


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
gcuucaaacg ugugugaau                                                    19


<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
agccguuucu aaacuuaau                                                    19


<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
cugaaauacg uuggauagu                                                    19


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
guuggauagu cguucuguu                                                    19


<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
ugccuuagcc uugucuaua                                                    19


<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
cuagccguuu cuaaacuua                                                    19


<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
gcaagcugug acuauagaa                                                    19


<210> 41
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
guguuaaguu ugugucuca                                                    19


<210> 42
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
ugcuagaagu guuaaguuu                                                    19


<210> 43
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
cagccacguu cuuuaaauu                                                    19


<210> 44
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
aaguuugugu cucaauacu                                                    19


<210> 45
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
agagcaagau uagaauaaa                                                    19


<210> 46
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
ugcauuacag aaugguaau                                                    19


<210> 47
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
uauuucaggg agcuaaguc                                                    19


<210> 48
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
auauagacaa ggcuaaggc                                                    19


<210> 49
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
auuucaggga gcuaagucu                                                    19


<210> 50
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
aauuuggcug cacuacacg                                                    19


<210> 51
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
acuuguacga cgaagacga                                                    19


<210> 52
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
ucuucccagg aggacauau                                                    19


<210> 53
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
aaacuugagc uguuccggc                                                    19


<210> 54
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
uccuuuaaac agauagaaa                                                    19


<210> 55
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
ucuaccaugg guuauaugg                                                    19


<210> 56
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
auucacacac guuugaagc                                                    19


<210> 57
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
auuaaguuua gaaacggcu                                                    19


<210> 58
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
acuauccaac guauuucag                                                    19


<210> 59
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
aacagaacga cuauccaac                                                    19


<210> 60
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
uauagacaag gcuaaggca                                                    19


<210> 61
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
uaaguuuaga aacggcuag                                                    19


<210> 62
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
uucuauaguc acagcuugc                                                    19


<210> 63
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
ugagacacaa acuuaacac                                                    19


<210> 64
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
aaacuuaaca cuucuagca                                                    19


<210> 65
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
aauuuaaaga acguggcug                                                    19


<210> 66
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
aguauugaga cacaaacuu                                                    19


<210> 67
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
uuuauucuaa ucuugcucu                                                    19


<210> 68
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
auuaccauuc uguaaugca                                                    19


<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
gacuuagcuc ccugaaauau u                                                 21


<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
gccuuagccu ugucuauauu u                                                 21


<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
agacuuagcu cccugaaauu u                                                 21


<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
cguguagugc agccaaauuu u                                                 21


<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
ucgucuucgu cguacaaguu u                                                 21


<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 74
auauguccuc cugggaagau u                                                 21


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 75
gccggaacag cucaaguuuu u                                                 21


<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 76
uuucuaucug uuuaaaggau u                                                 21


<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 77
ccauauaacc caugguagau u                                                 21


<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
gcuucaaacg ugugugaauu u                                                 21


<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
agccguuucu aaacuuaauu u                                                 21


<210> 80
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
cugaaauacg uuggauaguu u                                                 21


<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
guuggauagu cguucuguuu u                                                 21


<210> 82
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
ugccuuagcc uugucuauau u                                                 21


<210> 83
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
cuagccguuu cuaaacuuau u                                                 21


<210> 84
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
gcaagcugug acuauagaau u                                                 21


<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
guguuaaguu ugugucucau u                                                 21


<210> 86
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
ugcuagaagu guuaaguuuu u                                                 21


<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
cagccacguu cuuuaaauuu u                                                 21


<210> 88
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
aaguuugugu cucaauacuu u                                                 21


<210> 89
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
agagcaagau uagaauaaau u                                                 21


<210> 90
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
ugcauuacag aaugguaauu u                                                 21


<210> 91
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
uauuucaggg agcuaagucu u                                                 21


<210> 92
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
auauagacaa ggcuaaggcu u                                                 21


<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
auuucaggga gcuaagucuu u                                                 21


<210> 94
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
aauuuggcug cacuacacgu u                                                 21


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
acuuguacga cgaagacgau u                                                 21


<210> 96
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 96
ucuucccagg aggacauauu u                                                 21


<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 97
aaacuugagc uguuccggcu u                                                 21


<210> 98
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 98
uccuuuaaac agauagaaau u                                                 21


<210> 99
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 99
ucuaccaugg guuauauggu u                                                 21


<210> 100
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
auucacacac guuugaagcu u                                                 21


<210> 101
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
auuaaguuua gaaacggcuu u                                                 21


<210> 102
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
acuauccaac guauuucagu u                                                 21


<210> 103
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
aacagaacga cuauccaacu u                                                 21


<210> 104
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
uauagacaag gcuaaggcau u                                                 21


<210> 105
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
uaaguuuaga aacggcuagu u                                                 21


<210> 106
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
uucuauaguc acagcuugcu u                                                 21


<210> 107
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
ugagacacaa acuuaacacu u                                                 21


<210> 108
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
aaacuuaaca cuucuagcau u                                                 21


<210> 109
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
aauuuaaaga acguggcugu u                                                 21


<210> 110
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
aguauugaga cacaaacuuu u                                                 21


<210> 111
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
uuuauucuaa ucuugcucuu u                                                 21


<210> 112
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
auuaccauuc uguaaugcau u                                                 21


<210> 113
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> InvdT 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> invdT 

<400> 113
tauauguccu ccugggaaga uut                                               23


<210> 114
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe modified nucleotide 

<400> 114
ucuucccagg aggacauauu u                                                 21


<210> 115
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> invdT 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> invdT 

<400> 115
tauauguccu ccugggaaga uut                                               23


<210> 116
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe modified nucleotide 

<400> 116
ucuucccagg aggacauauu u                                                 21


<210> 117
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro modified nucleotide 

<400> 117
guccuccugg gaaga                                                        15


<210> 118
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro modified nucleotide 

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro modified nucleotide 

<400> 118
ucuucccagg aggacauauu                                                   20


