                         SEQUENCE LISTING

<110>  Yale University
       Stabach, Paul
       Braddock, Demetrios
 
<120>  ENPP1 Polypeptides and Methods of Using Same

<130>  047162-7180WO2

<150>  US 62/830,230
<151>  2019-04-05

<150>  US 62/983,142
<151>  2020-02-28

<150>  US 62/984,650
<151>  2020-03-03

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  2
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Ala Glu Thr Arg Lys Phe Arg Gly Ser Arg Asn Glu Asn Lys Glu 
        595                 600                 605             


Asn Ile Asn Gly Asn Phe Glu Pro Arg Lys Glu Arg His Leu Leu Tyr 
    610                 615                 620                 


Gly Arg Pro Ala Val Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His 
625                 630                 635                 640 


Thr Asp Phe Glu Ser Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp 
                645                 650                 655     


Thr Ser Tyr Thr Val Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp 
            660                 665                 670         


His Leu Thr Ser Cys Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe 
        675                 680                 685             


Ser Gln Asn Cys Leu Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly 
    690                 695                 700                 


Phe Leu Phe Pro Pro Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp 
705                 710                 715                 720 


Ala Phe Leu Val Thr Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg 
                725                 730                 735     


Val Trp Asn Tyr Phe Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu 
            740                 745                 750         


Arg Asn Gly Val Asn Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr 
        755                 760                 765             


Asp Gly Leu His Asp Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly 
    770                 775                 780                 


Ser Ser Ile Pro Val Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys 
785                 790                 795                 800 


Leu Asp Phe Thr Gln Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val 
                805                 810                 815     


Ser Ser Phe Ile Leu Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn 
            820                 825                 830         


Ser Ser Glu Asp Glu Ser Lys Trp Val Glu Glu Leu Met Lys Met His 
        835                 840                 845             


Thr Ala Arg Val Arg Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe 
    850                 855                 860                 


Arg Lys Thr Ser Arg Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr 
865                 870                 875                 880 


Leu His Thr Tyr Glu Ser Glu Ile 
                885             


<210>  3
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa23 is absent or Leu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa24 is absent if Xaa23 is absent, and Xaa24 is absent or Gln if
       Xaa23 is Leu

<400>  4

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Xaa Xaa 
            20                  


<210>  5
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala 
            20          


<210>  6
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala 
            20  


<210>  7
<211>  1078
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  7

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys 
            20                  25                  30          


Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala 
        35                  40                  45              


Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys 
    50                  55                  60                  


Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu 
65                  70                  75                  80  


Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp 
                85                  90                  95      


Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys 
            100                 105                 110         


Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro 
        115                 120                 125             


Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe 
    130                 135                 140                 


Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser 
145                 150                 155                 160 


Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr 
                165                 170                 175     


Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr 
            180                 185                 190         


Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met 
        195                 200                 205             


Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp 
    210                 215                 220                 


Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys 
225                 230                 235                 240 


Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile 
                245                 250                 255     


Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu 
            260                 265                 270         


Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg 
        275                 280                 285             


Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His 
    290                 295                 300                 


Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val 
305                 310                 315                 320 


Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu 
                325                 330                 335     


His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln 
            340                 345                 350         


Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val 
        355                 360                 365             


Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser 
    370                 375                 380                 


Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg 
385                 390                 395                 400 


Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys 
                405                 410                 415     


His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu 
            420                 425                 430         


Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro 
        435                 440                 445             


Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val 
    450                 455                 460                 


Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys 
465                 470                 475                 480 


His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu 
                485                 490                 495     


Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His 
            500                 505                 510         


Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His 
        515                 520                 525             


Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro 
    530                 535                 540                 


Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu 
545                 550                 555                 560 


Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile 
                565                 570                 575     


Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu 
            580                 585                 590         


Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser 
        595                 600                 605             


Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn 
    610                 615                 620                 


Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe 
625                 630                 635                 640 


Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn 
                645                 650                 655     


Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn 
            660                 665                 670         


Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro 
        675                 680                 685             


Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu 
    690                 695                 700                 


Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly 
705                 710                 715                 720 


Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn 
                725                 730                 735     


Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro 
            740                 745                 750         


Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr 
        755                 760                 765             


Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His 
    770                 775                 780                 


Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser 
785                 790                 795                 800 


Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val 
                805                 810                 815     


Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val 
            820                 825                 830         


Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu 
        835                 840                 845             


Asp Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    850                 855                 860                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
865                 870                 875                 880 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                885                 890                 895     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            900                 905                 910         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        915                 920                 925             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    930                 935                 940                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
945                 950                 955                 960 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                965                 970                 975     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            980                 985                 990         


Gln Val Ser Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
        995                 1000                 1005             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1010                 1015                 1020             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1025                 1030                 1035             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1040                 1045                 1050             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1055                 1060                 1065             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1070                 1075             


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  8

Leu Ile Asn 
1           


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  10

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
            820                 825         


<210>  11
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  11

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
            820                 825         


<210>  12
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  12

Pro Ser Cys Ala Lys Glu Asn Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Asn 
            500                 505                 510         


Leu Thr Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
            820                 825         


<210>  13
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  14
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  14

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  15
<211>  1059
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  15

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Gly Gly Gly Gly Ser 
            820                 825                 830         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        835                 840                 845             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
    850                 855                 860                 


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
865                 870                 875                 880 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                885                 890                 895     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            900                 905                 910         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        915                 920                 925             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    930                 935                 940                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
945                 950                 955                 960 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                965                 970                 975     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            980                 985                 990         


Trp Glu Ser Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
        995                 1000                 1005             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1010                 1015                 1020             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1025                 1030                 1035             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1040                 1045                 1050             


Ser Leu  Ser Pro Gly Lys 
    1055                 


<210>  16
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  16

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys 
            820                 825                 830         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        835                 840                 845             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr 
    850                 855                 860                 


Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
865                 870                 875                 880 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                885                 890                 895     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            900                 905                 910         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        915                 920                 925             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    930                 935                 940                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
945                 950                 955                 960 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                965                 970                 975     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            980                 985                 990         


Ser Asn Gly Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
        995                 1000                 1005             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1010                 1015                 1020             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1025                 1030                 1035             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1040                 1045                 1050             


Ser Pro  Gly Lys 
    1055         


<210>  17
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  17

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys 
            820                 825                 830         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        835                 840                 845             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr 
    850                 855                 860                 


Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
865                 870                 875                 880 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                885                 890                 895     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            900                 905                 910         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        915                 920                 925             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    930                 935                 940                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
945                 950                 955                 960 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                965                 970                 975     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            980                 985                 990         


Ser Asn Gly Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
        995                 1000                 1005             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1010                 1015                 1020             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1025                 1030                 1035             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1040                 1045                 1050             


Ser Pro  Gly Lys 
    1055         


<210>  18
<211>  1059
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly synthesized

<400>  18

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Gly Gly Gly Gly Ser 
            820                 825                 830         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        835                 840                 845             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
    850                 855                 860                 


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
865                 870                 875                 880 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                885                 890                 895     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            900                 905                 910         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        915                 920                 925             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    930                 935                 940                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
945                 950                 955                 960 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                965                 970                 975     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            980                 985                 990         


Trp Glu Ser Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
        995                 1000                 1005             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1010                 1015                 1020             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1025                 1030                 1035             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1040                 1045                 1050             


Ser Leu  Ser Pro Gly Lys 
    1055                 


