                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> METHODS, COMPOSITIONS, AND KITS FOR PRODUCING SKELETAL MUSCLE 
      STEM CELLS AND TREATING DISORDERS

<130> 048317-563001WO

<140> PCT/US2020/026603
<141> 2020-04-03

<150> 62/828,973
<151> 2019-04-03

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 520
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ala Leu Pro Gly Thr Val Pro Arg Met Met Arg Pro Ala Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Thr Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Arg Gln Val Ala Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Arg Leu Leu Lys Asp Gly His Cys Asp 
    130                 135                 140                 


Arg Ser Thr Val Pro Ser Gly Leu Val Ser Ser Ile Ser Arg Val Leu 
145                 150                 155                 160 


Arg Ile Lys Phe Gly Lys Lys Glu Glu Glu Asp Glu Ala Asp Lys Lys 
                165                 170                 175     


Glu Asp Asp Gly Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Gly Asp Lys Gly Asn Arg Leu Asp Glu Gly Ser Asp Val Glu Ser Glu 
        195                 200                 205             


Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr Phe 
    210                 215                 220                 


Thr Ala Glu Gln Leu Glu Glu Leu Glu Lys Ala Phe Glu Arg Thr His 
225                 230                 235                 240 


Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Thr Lys Leu 
                245                 250                 255     


Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg Trp 
            260                 265                 270         


Arg Lys Gln Ala Gly Ala Asn Gln Leu Ala Ala Phe Asn His Leu Leu 
        275                 280                 285             


Pro Gly Gly Phe Pro Pro Thr Gly Met Pro Thr Leu Pro Pro Tyr Gln 
    290                 295                 300                 


Leu Pro Asp Ser Thr Tyr Pro Thr Thr Thr Ile Ser Gln Asp Gly Gly 
305                 310                 315                 320 


Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro Ser Thr Met His Gln 
                325                 330                 335     


Gly Gly Leu Ala Ala Ala Ala Ala Ala Ala Asp Thr Ser Ser Ala Tyr 
            340                 345                 350         


Gly Ala Arg His Ser Phe Ser Ser Tyr Ser Asp Ser Phe Met Asn Pro 
        355                 360                 365             


Ala Ala Pro Ser Asn His Met Asn Pro Val Ser Asn Gly Leu Ser Pro 
    370                 375                 380                 


Gln Val Met Ser Ile Leu Gly Asn Pro Ser Ala Val Pro Pro Gln Pro 
385                 390                 395                 400 


Gln Ala Asp Phe Ser Ile Ser Pro Leu His Gly Gly Leu Asp Ser Ala 
                405                 410                 415     


Thr Ser Ile Ser Ala Ser Cys Ser Gln Arg Ala Asp Ser Ile Lys Pro 
            420                 425                 430         


Gly Asp Ser Leu Pro Thr Ser Gln Ala Tyr Cys Pro Pro Thr Tyr Ser 
        435                 440                 445             


Thr Thr Gly Tyr Ser Val Asp Pro Val Ala Gly Tyr Gln Tyr Gly Gln 
    450                 455                 460                 


Tyr Gly Gln Ser Glu Cys Leu Val Pro Trp Ala Ser Pro Val Pro Ile 
465                 470                 475                 480 


Pro Ser Pro Thr Pro Arg Ala Ser Cys Leu Phe Met Glu Ser Tyr Lys 
                485                 490                 495     


Val Val Ser Gly Trp Gly Met Ser Ile Ser Gln Met Glu Lys Leu Lys 
            500                 505                 510         


Ser Ser Gln Met Glu Gln Phe Thr 
        515                 520 


<210> 2
<211> 2271
<212> DNA
<213> Homo sapiens

<400> 2
gaaagctggt gtggagggag aagcgagtgt ggtccggaga aagaaggcgt ggagaagagg       60

gagggagcga gagcgagaga ataaatatat aaataaatac gagaacgaaa tccactccgc      120

agtctccggg ctcggaaact ttggccccga gcgccagagc gccagagcgc gagagcgcgg      180

cgctcgccac tctgaggctg gcggcctcga ttccggccgc gttcccccgg cccccctccg      240

ccgcggggcc tggtctccgg gttctgccag gcgcatcagc ccgcacaact tctggccgag      300

gccagccggc agaggcggac ttggggttgg agtgtttgtt tgtttgaact tcctcgtcgt      360

cgccaccttc cctcccccca acctccaccc cacctcaccc ccctccccag cttctggacg      420

cgtttgactg cagccagggg tggggggtgg gggtagggag tgtgtgtgga ggggagggag      480

aagaggttaa aaaaaagaag acgaagaaga cggaaagaaa gagatcgcag caggggtgaa      540

gggagcggac gggaagcgat ttttgccgac tttggattcg tccccggcgt gcgcaagaat      600

ggcggccctt cccggcacgg taccgagaat gatgcggccg gctccggggc agaactaccc      660

ccgcacggga ttccctttgg aagtgtccac cccgcttggc caaggccggg tcaatcagct      720

gggaggggtc ttcatcaatg ggcgacccct gcctaaccac atccgccaca agatagtgga      780

gatggcccac catggcatcc ggccctgtgt catctcccga cagctgcgtg tctcccacgg      840

ctgcgtctcc aagattcttt gccgctacca ggagaccggg tccatccggc ctggggccat      900

cggcggcagc aagcccagac aggtggcgac tccggatgta gagaaaaaga ttgaggagta      960

caagagggaa aacccaggca tgttcagctg ggagatccgg gacaggctgc tgaaggatgg     1020

gcactgtgac cgaagcactg tgccctcagg tttagtgagt tcgattagcc gcgtgctcag     1080

aatcaagttc gggaagaaag aggaggagga tgaagcggac aagaaggagg acgacggcga     1140

aaagaaggcc aaacacagca tcgacggcat cctgggcgac aaagggaacc ggctggacga     1200

gggctcggat gtggagtcgg aacctgacct cccactgaag cgcaagcagc gacgcagtcg     1260

gaccacattc acggccgagc agctggagga gctggagaag gcctttgaga ggacccacta     1320

cccagacata tacacccgcg aggagctggc gcagaggacc aagctgacag aggcgcgtgt     1380

gcaggtctgg ttcagtaacc gccgcgcccg ttggcgtaag caggcaggag ccaaccagct     1440

ggcggcgttc aaccaccttc tgccaggagg cttcccaccc accggcatgc ccacgctgcc     1500

cccctaccag ctgccggact ccacctaccc caccaccacc atctcccaag atgggggcag     1560

cactgtgcac cggcctcagc ccctgccacc gtccaccatg caccagggcg ggctggctgc     1620

agcggctgca gccgccgaca ccagctctgc ctacggagcc cgccacagct tctccagcta     1680

ctctgacagc ttcatgaatc cggcggcgcc ctccaaccac atgaacccgg tcagcaacgg     1740

cctgtctcct caggtgatga gcatcttggg caaccccagt gcggtgcccc cgcagccaca     1800

ggctgacttc tccatctccc cgctgcatgg cggcctggac tcggccacct ccatctcagc     1860

cagctgcagc cagcgggccg actccatcaa gccaggagac agcctgccca cctcccaggc     1920

ctactgccca cccacctaca gcaccaccgg ctacagcgtg gaccccgtgg ccggctatca     1980

gtacggccag tacggccaga gtgagtgcct ggtgccctgg gcgtcccccg tccccattcc     2040

ttctcccacc cccagggcct cctgcttgtt tatggagagc tacaaggtgg tgtcagggtg     2100

gggaatgtcc atttcacaga tggaaaaatt gaagtccagc cagatggaac agttcaccta     2160

aaatgacact gagttgggca aaacccagga catctcctgg ctaagcctct gcttccgtac     2220

tatggctcca acagaaataa aatacacaac acaaatatca aaaaaaaaaa a              2271


<210> 3
<211> 503
<212> PRT
<213> Mus musculus

<400> 3
Met Ala Ala Leu Pro Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Thr Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Arg Gln Val Ala Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Arg Leu Leu Lys Asp Gly His Cys Asp 
    130                 135                 140                 


Arg Ser Thr Val Pro Ser Val Ser Ser Ile Ser Arg Val Leu Arg Ile 
145                 150                 155                 160 


Lys Phe Gly Lys Lys Glu Asp Asp Glu Glu Gly Asp Lys Lys Glu Glu 
                165                 170                 175     


Asp Gly Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu Gly Asp 
            180                 185                 190         


Lys Gly Asn Arg Leu Asp Glu Gly Ser Asp Val Glu Ser Glu Pro Asp 
        195                 200                 205             


Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr Phe Thr Ala 
    210                 215                 220                 


Glu Gln Leu Glu Glu Leu Glu Lys Ala Phe Glu Arg Thr His Tyr Pro 
225                 230                 235                 240 


Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Thr Lys Leu Thr Glu 
                245                 250                 255     


Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg Trp Arg Lys 
            260                 265                 270         


Gln Ala Gly Ala Asn Gln Leu Ala Ala Phe Asn His Leu Leu Pro Gly 
        275                 280                 285             


Gly Phe Pro Pro Thr Gly Met Pro Thr Leu Pro Pro Tyr Gln Leu Pro 
    290                 295                 300                 


Asp Ser Thr Tyr Pro Thr Thr Thr Ile Ser Gln Asp Gly Gly Ser Thr 
305                 310                 315                 320 


Val His Arg Pro Gln Pro Leu Pro Pro Ser Thr Met His Gln Gly Gly 
                325                 330                 335     


Leu Ala Ala Ala Ala Ala Ala Ala Asp Thr Ser Ser Ala Tyr Gly Ala 
            340                 345                 350         


Arg His Ser Phe Ser Ser Tyr Ser Asp Ser Phe Met Asn Pro Gly Ala 
        355                 360                 365             


Pro Ser Asn His Met Asn Pro Val Ser Asn Gly Leu Ser Pro Gln Val 
    370                 375                 380                 


Met Ser Ile Leu Ser Asn Pro Ser Ala Val Pro Pro Gln Pro Gln Ala 
385                 390                 395                 400 


Asp Phe Ser Ile Ser Pro Leu His Gly Gly Leu Asp Ser Ala Ser Ser 
                405                 410                 415     


Ile Ser Ala Ser Cys Ser Gln Arg Ala Asp Ser Ile Lys Pro Gly Asp 
            420                 425                 430         


Ser Leu Pro Thr Ser Gln Ser Tyr Cys Pro Pro Thr Tyr Ser Thr Thr 
        435                 440                 445             


Gly Tyr Ser Val Asp Pro Val Ala Gly Tyr Gln Tyr Ser Gln Tyr Gly 
    450                 455                 460                 


Gln Thr Ala Val Asp Tyr Leu Ala Lys Asn Val Ser Leu Ser Thr Gln 
465                 470                 475                 480 


Arg Arg Met Lys Leu Gly Glu His Ser Ala Val Leu Gly Leu Leu Pro 
                485                 490                 495     


Val Glu Thr Gly Gln Ala Tyr 
            500             


<210> 4
<211> 4275
<212> DNA
<213> Mus musculus

<400> 4
agagacgcca agaggtttat ccagccgact ctggattcgt ctccagcgtg cgcaggaatg       60

gcggcgctgc ccggcgcggt ccccaggatg atgagacccg gcccggggca gaactacccg      120

cgcaccggct tccccctgga agtgtccacc cctcttggcc aaggccgggt caatcagctt      180

ggtggggtct tcatcaacgg tcgacccctg ccgaaccaca tccgtcacaa gatagtggaa      240

atggcccacc atggcatccg gccctgcgtc atctcccgtc agctccgtgt ttcccatggt      300

tgtgtctcca agattctgtg ccgatatcag gagactgggt ccatccggcc cggggctatc      360

ggaggcagca agcccagaca ggtggcgact ccggatgtgg agaaaaagat tgaggagtat      420

aagagagaga accccgggat gttcagctgg gaaatccggg accggctgct gaaggacggt      480

cactgcgacc gaagcacggt gccctcagtg agttcgatta gccgagtgct cagaatcaag      540

ttcgggaaga aagaggacga cgaggaagga gacaagaaag aagaagatgg cgagaagaaa      600

gccaaacaca gcatcgatgg catcctgggc gacaaaggga accgtctgga tgagggctca      660

gatgtggaat cagaacccga cctccccctg aagcgcaagc agcgccgcag tcggaccacg      720

ttcacagccg agcagctgga ggagctggag aaggccttcg agaggaccca ctacccggac      780

atctacaccc gggaggagct ggcacagagg accaagctca cggaggcacg cgtccaggtc      840

tggttcagta accggcgtgc ccgctggcgt aagcaggcag gagctaacca gctggccgcc      900

ttcaaccacc ttctgccggg aggtttccca cccaccggca tgcccacgct gccaccctac      960

cagctgccgg actctaccta ccccaccacc accatctccc aagatggagg cagcacagta     1020

cacaggcccc agccccttcc gccatcaacc atgcatcagg gtgggctggc tgcggccgct     1080

gcagcagcgg acaccagctc tgcctacgga gcccgccaca gcttctccag ctactctgac     1140

agcttcatga accctggggc tccctccaac cacatgaacc ctgtcagcaa tggcctgtct     1200

cctcaggtca tgagcatcct tagcaacccg agtgccgtgc ctccacagcc ccaggccgac     1260

ttctccatct ccccgctgca tggaggcctg gactcggctt cctccatctc agccagctgc     1320

agccaacggg ccgactccat caagccagga gacagcttgc ccacgtccca gtcttactgc     1380

ccacccacct acagcaccac tggctacagt gtggaccctg tggctggcta ccagtacagc     1440

cagtatggcc aaactgctgt tgattacctg gccaaaaacg tgagcctgtc cacacagcgc     1500

cgtatgaagc ttggggaaca ctccgctgtg ctgggacttc ttcctgtgga aacgggacaa     1560

gcctactagg gtccctgggg caacttgccc catccagtgg cccagccaac ccttcccaag     1620

ccctgagtct cctcacctca gtccccttat ccccctgggg ttgcaggaga ccaagggaaa     1680

aaaacccttt cccttcctac aggaaaccct ctggagacgg aaaaccagtg tgccatctac     1740

ccatgcttag tgacccagag tggccccttg ccttcccctc tttcttcaga ggggttccta     1800

ggcatcctgc agtgacctcc agctcacatc caccttctct gtatcgtggc ctcggtcctg     1860

tctcagtgca gagattgagg ctcaatttga accaagcacc tagttatcag aagaaaatgg     1920

tgccaaagac aaggccctgg agtccttgac ctctgagtcg tgggtgccct ggctatgggt     1980

gtaggtggag cccatgggtg tcctcagtca cagagctggg agctctctct cgctcgcttg     2040

gcatcaggac tgcagcctct ttcactggac actgagatga gtccccaggg tgttcccagg     2100

ggagaaagca ggtaacatcc cagctttacc taggaatcca gaggacttta ggactgtccc     2160

tatgcaccct gcagggcatc aggagaccag gaagggattc tagcagaggg tagggggcac     2220

agaggcagag ctgattgccc atgggctatc ccagaatgcc tggtcctgaa tctagcatca     2280

ggaggtgcag gattcctagg ctgcaatctg acagaggctt gcccactgtg tcaggcctgg     2340

gcagcccaca gaacctgtca ctctcctcaa ttggtaggag aagaggtctt gaggtgacag     2400

gaggcagaag gcaggctcag acagtcagag agcaccaagc tttcaagtcc gcacccctgg     2460

ggttcggcat accatcttgc tggcagctgg aaacctggtt ccctgaaagg gggcctccat     2520

cctccagaat gtaaggctct tgatgccacc ggatgcagag agccttctcg ggccagacaa     2580

aattgctgct ccaccccaga gaagatgttc cagccttctt ggcatcttag aggaaggcca     2640

tgtcgctgtc cttttcagag tagcatattt ttcagtgatg gctgctcagt caggaggctt     2700

ctgtcgcctt acaaagcaca gtgcgctctg ggcactgttt ctaagccacc ccatcccacc     2760

cccacccccg ccaccccggg gacagaggaa gatgctaaaa gtcccagcaa agaggacaaa     2820

gcacctttct taagcactcc agagtcttcc ttgtaccccg ccctctctta gagctgggtc     2880

ttttgaggga aacggattgc tgagccctcc ccccccccca atcctctcct ctgtggagct     2940

gtttatcatc ctctatttat caaaatcgca tccatcttta ccctctcctt cgctatagcc     3000

tacttctgga tcaccctcat ccagtgctgg taccccacag cactaaatcc aggaaccctg     3060

ggcttgatca cctgttgcca cctgtacaca tgaaaccacc tgctggcccg gcccatgtct     3120

cctgccctca gccagcaaga cattcctaga gagaggaact atgggcttaa aagccccaac     3180

tgacttcctt ttgcctgggg acctgaaccg acaagacacc agggacactt gtctacatga     3240

acatgtgacc aatgtacacc gatttctcat ctctagacct attatctgaa gcctgtcccg     3300

ggccatgact agaatggctt gtatctgtgg tttagagaag tctaataata actgagggca     3360

aactgactct ctggtagcat ggagcaccag gcggatggag ctcaccagct ctgtccaggt     3420

ttcaaaggag gagactgttg ggctcttcaa ggtctggaca agaggaaagc cacattgccc     3480

ccttgggaac ccaggttctc cttttgaact tctcacagct gcaagcaccc ctttcaaaga     3540

ccaaatgcat cctcctccac attccttgct ccctggaggc ctggctctgg atacacctga     3600

gtcttcgttc acctactaca ctttaggagc aggaacttca agcaggtgac atccacaggg     3660

cccagtccca gccaagggag caacattcca acgcttggac caatcataat gatctgcccg     3720

tgagggtaac cgcaactaga gacctgcttg ggagaaaaca aaatgacttc tcattccatg     3780

ccatgcctct gaatgctccc ccaagctgcc atcttggtat aaaatgggac ttgtgttgtg     3840

gggaacccct tgaccccaac aggttttccc aactgtctca tgcttttgtg aatctgtctg     3900

ctttgatctg taaaactcag ccttgtttgg gcagcttgta atttcaacag tgaggcgaca     3960

tcgattagat gagaggcacc aggcctctcc gccgccgtcc ctctgtggcc gtccctctgg     4020

ggttgagcag aacctagaag aaggccgatt tccagtggcc agactggacc agaaacagcc     4080

cccaccccaa tccctgtaaa tagagtcaat agcaaaataa gaggggcgcc ctccatgtca     4140

cctcaagtag ctactggttc ttctgtggag gcccctctga actcattgtc tggtagttga     4200

aaatgtgatg ttgtgctgtt tgtttataga acattggctt tttatatata aatctatata     4260

cttaaaaaca aaaac                                                      4275


<210> 5
<211> 320
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Leu Leu Ser Pro Pro Leu Arg Asp Val Asp Leu Thr Ala Pro 
1               5                   10                  15      


Asp Gly Ser Leu Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp 
            20                  25                  30          


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
        35                  40                  45              


Arg Leu Met His Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His 
    50                  55                  60                  


Phe Pro Ala Ala Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His 
65                  70                  75                  80  


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
                85                  90                  95      


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
            100                 105                 110         


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
        115                 120                 125             


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
    130                 135                 140                 


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
145                 150                 155                 160 


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
                165                 170                 175     


Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His 
            180                 185                 190         


Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp 
        195                 200                 205             


Gly Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn 
    210                 215                 220                 


Cys Tyr Glu Gly Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro 
225                 230                 235                 240 


Gly Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val 
                245                 250                 255     


Glu Arg Ile Ser Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala 
            260                 265                 270         


Asp Val Pro Ser Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro 
        275                 280                 285             


Ser Glu Gly Glu Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala 
    290                 295                 300                 


Pro Gln Cys Pro Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu 
305                 310                 315                 320 


<210> 6
<211> 1803
<212> DNA
<213> Homo sapiens

<400> 6
aggggtgagg aagccctggg gcgctgccgc cgctttcctt aaccacaaat caggccggac       60

aggagaggga ggggtggggg acagtgggtg ggcattcaga ctgccagcac tttgctatct      120

acagccgggg ctcccgagcg gcagaaagtt ccggccactc tctgccgctt gggttgggcg      180

aagccaggac cgtgccgcgc caccgccagg atatggagct actgtcgcca ccgctccgcg      240

acgtagacct gacggccccc gacggctctc tctgctcctt tgccacaacg gacgacttct      300

atgacgaccc gtgtttcgac tccccggacc tgcgcttctt cgaagacctg gacccgcgcc      360

tgatgcacgt gggcgcgctc ctgaaacccg aagagcactc gcacttcccc gcggcggtgc      420

acccggcccc gggcgcacgt gaggacgagc atgtgcgcgc gcccagcggg caccaccagg      480

cgggccgctg cctactgtgg gcctgcaagg cgtgcaagcg caagaccacc aacgccgacc      540

gccgcaaggc cgccaccatg cgcgagcggc gccgcctgag caaagtaaat gaggcctttg      600

agacactcaa gcgctgcacg tcgagcaatc caaaccagcg gttgcccaag gtggagatcc      660

tgcgcaacgc catccgctat atcgagggcc tgcaggctct gctgcgcgac caggacgccg      720

cgccccctgg cgccgcagcc gccttctatg cgccgggccc gctgcccccg ggccgcggcg      780

gcgagcacta cagcggcgac tccgacgcgt ccagcccgcg ctccaactgc tccgacggca      840

tgatggacta cagcggcccc ccgagcggcg cccggcggcg gaactgctac gaaggcgcct      900

actacaacga ggcgcccagc gaacccaggc ccgggaagag tgcggcggtg tcgagcctag      960

actgcctgtc cagcatcgtg gagcgcatct ccaccgagag ccctgcggcg cccgccctcc     1020

tgctggcgga cgtgccttct gagtcgcctc cgcgcaggca agaggctgcc gcccccagcg     1080

agggagagag cagcggcgac cccacccagt caccggacgc cgccccgcag tgccctgcgg     1140

gtgcgaaccc caacccgata taccaggtgc tctgagggga tggtggccgc ccacccgccc     1200

gagggatggt gcccctaggg tccctcgcgc ccaaaagatt gaacttaaat gcccccctcc     1260

caacagcgct ttaaaagcga cctctcttga ggtaggagag gcgggagaac tgaagtttcc     1320

gcccccgccc cacagggcaa ggacacagcg cggttttttc cacgcagcac ccttctcgga     1380

gacccattgc gatggccgct ccgtgttcct cggtgggcca gagctgaacc ttgaggggct     1440

aggttcagct ttctcgcgcc ctcccccatg ggggtgagac cctcgcagac ctaagccctg     1500

ccccgggatg caccggttat ttgggggggc gtgagaccca gtgcactccg gtcccaaatg     1560

tagcaggtgt aaccgtaacc cacccccaac ccgtttcccg gttcaggacc actttttgta     1620

atacttttgt aatctattcc tgtaaataag agttgctttg ccagagcagg agcccctggg     1680

gctgtattta tctctgaggc atggtgtgtg gtgctacagg gaatttgtac gtttataccg     1740

caggcgggcg agccgcgggc gctcgctcag gtgatcaaaa taaaggcgct aatttatacc     1800

gcc                                                                   1803


<210> 7
<211> 318
<212> PRT
<213> Mus musculus

<400> 7
Met Glu Leu Leu Ser Pro Pro Leu Arg Asp Ile Asp Leu Thr Gly Pro 
1               5                   10                  15      


Asp Gly Ser Leu Cys Ser Phe Glu Thr Ala Asp Asp Phe Tyr Asp Asp 
            20                  25                  30          


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
        35                  40                  45              


Arg Leu Val His Met Gly Ala Leu Leu Lys Pro Glu Glu His Ala His 
    50                  55                  60                  


Phe Pro Thr Ala Val His Pro Gly Pro Gly Ala Arg Glu Asp Glu His 
65                  70                  75                  80  


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
                85                  90                  95      


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
            100                 105                 110         


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
        115                 120                 125             


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
    130                 135                 140                 


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
145                 150                 155                 160 


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
                165                 170                 175     


Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Ser Glu His Tyr 
            180                 185                 190         


Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp Gly 
        195                 200                 205             


Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Pro Arg Arg Gln Asn Gly 
    210                 215                 220                 


Tyr Asp Thr Ala Tyr Tyr Ser Glu Ala Ala Arg Glu Ser Arg Pro Gly 
225                 230                 235                 240 


Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val Glu 
                245                 250                 255     


Arg Ile Ser Thr Asp Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala Asp 
            260                 265                 270         


Ala Pro Pro Glu Ser Pro Pro Gly Pro Pro Glu Gly Ala Ser Leu Ser 
        275                 280                 285             


Asp Thr Glu Gln Gly Thr Gln Thr Pro Ser Pro Asp Ala Ala Pro Gln 
    290                 295                 300                 


Cys Pro Ala Gly Ser Asn Pro Asn Ala Ile Tyr Gln Val Leu 
305                 310                 315             


<210> 8
<211> 1854
<212> DNA
<213> Mus musculus

<400> 8
aggggccagg acgccccagg acacgactgc tttcttcacc actcctctga caggacagga       60

cagggaggag gggtagagga cagccggtgt gcattccaac ccacagaacc tttgtcattg      120

tactgttggg gttccggagt ggcagaaagt taagacgact ctcacggctt gggttgaggc      180

tggacccagg aactgggata tggagcttct atcgccgcca ctccgggaca tagacttgac      240

aggccccgac ggctctctct gctcctttga gacagcagac gacttctatg atgacccgtg      300

tttcgactca ccagacctgc gcttttttga ggacctggac ccgcgcctgg tgcacatggg      360

agccctcctg aaaccggagg agcacgcaca cttccctact gcggtgcacc caggcccagg      420

cgctcgtgag gatgagcatg tgcgcgcgcc cagcgggcac caccaggcgg gtcgctgctt      480

gctgtgggcc tgcaaggcgt gcaagcgcaa gaccaccaac gctgatcgcc gcaaggccgc      540

caccatgcgc gagcgccgcc gcctgagcaa agtgaatgag gccttcgaga cgctcaagcg      600

ctgcacgtcc agcaacccga accagcggct acccaaggtg gagatcctgc gcaacgccat      660

ccgctacatc gaaggtctgc aggctctgct gcgcgaccag gacgccgcgc cccctggcgc      720

cgctgccttc tacgcacctg gaccgctgcc cccaggccgt ggcagcgagc actacagtgg      780

cgactcagat gcatccagcc cgcgctccaa ctgctctgat ggcatgatgg attacagcgg      840

ccccccaagc ggcccccggc ggcagaatgg ctacgacacc gcctactaca gtgaggcggc      900

gcgcgagtcc aggccaggga agagtgcggc tgtgtcgagc ctcgactgcc tgtccagcat      960

agtggagcgc atctccacag acagccccgc tgcgcctgcg ctgcttttgg cagatgcacc     1020

accagagtcg cctccgggtc cgccagaggg ggcatcccta agcgacacag aacagggaac     1080

ccagaccccg tctcccgacg ccgcccctca gtgtcctgca ggctcaaacc ccaatgcgat     1140

ttatcaggtg ctttgagaga tcgactgcag cagcagaggg cgcaccaccg taggcactcc     1200

tggggatggt gtccctggtt cttcacgccc aaaagatgaa gcttaaatga cactcttccc     1260

aactgtcctt tcgaagccgt tcttccagag ggaagggaag agcagaagtc tgtcctagat     1320

ccagccccaa agaaaggaca tagtcctttt tgttgttgtt gttgtagtcc ttcagttgtt     1380

tgtttgtttt ttcatgcggc tcacagcgaa ggccacttgc actctggctg cacctcactg     1440

ggccagagct gatccttgag tggccaggcg ctcttccttt cctcatagca caggggtgag     1500

ccttgcacac ctaagccctg ccctccacat ccttttgttt gtcactttct ggagccctcc     1560

tggcacccac ttttccccac agcttgcgga ggccactcag gtctcaggtg taacaggtgt     1620

aaccataccc cactctcccc cttcccgcgg ttcaggacca cttatttttt tatataagac     1680

ttttgtaatc tattcgtgta aataagagtt gcttggccag agcgggagcc ccttgggcta     1740

tatttatctc ccaggcatgc tgtgtagtgc aacaaaaact ttgtatgttt attcctcaag     1800

cgggcgagcc tcgaggctcg ctcgctcagg tgttggaaat aaagacgcta attt           1854


