                         SEQUENCE LISTING

<110>  REGENXBIO Inc.
 
<120>  GENE THERAPY FOR EYE PATHOLOGIES

<130>  12656-126-228

<140>  TBA
<141>  

<150>  US 62/946,158
<151>  2019-12-10

<150>  US 62/828,949
<151>  2019-04-03

<150>  US 62/856,533
<151>  2019-06-03

<160>  321   

<170>  PatentIn version 3.5

<210>  1
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Fab Amino Acid Sequence - light chain

<400>  1

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Fab Amino Acid Sequence - heavy chain

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210>  3
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab Fab Amino Acid Sequence - Light chain

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  4
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab Fab Amino Acid Sequence - Heavy chain

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF-A signal peptide

<400>  5

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala 
            20                  25      


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibulin-1 signal peptide

<400>  6

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vitronectin signal peptide

<400>  7

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H signal peptide

<400>  8

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala 
        


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opticin signal peptide

<400>  9

Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr 
            


<210>  10
<211>  728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bevacizumab cDNA - Light chain

<400>  10
gctagcgcca ccatgggctg gtcctgcatc atcctgttcc tggtggccac cgccaccggc       60

gtgcactccg acatccagat gacccagtcc ccctcctccc tgtccgcctc cgtgggcgac      120

cgggtgacca tcacctgctc cgcctcccag gacatctcca actacctgaa ctggtaccag      180

cagaagcccg gcaaggcccc caaggtgctg atctacttca cctcctccct gcactccggc      240

gtgccctccc ggttctccgg ctccggctcc ggcaccgact tcaccctgac catctcctcc      300

ctgcagcccg aggacttcgc cacctactac tgccagcagt actccaccgt gccctggacc      360

ttcggccagg gcaccaaggt ggagatcaag cggaccgtgg ccgccccctc cgtgttcatc      420

ttccccccct ccgacgagca gctgaagtcc ggcaccgcct ccgtggtgtg cctgctgaac      480

aacttctacc cccgggaggc caaggtgcag tggaaggtgg acaacgccct gcagtccggc      540

aactcccagg agtccgtgac cgagcaggac tccaaggact ccacctactc cctgtcctcc      600

accctgaccc tgtccaaggc cgactacgag aagcacaagg tgtacgcctg cgaggtgacc      660

caccagggcc tgtcctcccc cgtgaccaag tccttcaacc ggggcgagtg ctgagcggcc      720

gcctcgag                                                               728


<210>  11
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bevacizumab cDNA - heavy chain

<400>  11
gctagcgcca ccatgggctg gtcctgcatc atcctgttcc tggtggccac cgccaccggc       60

gtgcactccg aggtgcagct ggtggagtcc ggcggcggcc tggtgcagcc cggcggctcc      120

ctgcggctgt cctgcgccgc ctccggctac accttcacca actacggcat gaactgggtg      180

cggcaggccc ccggcaaggg cctggagtgg gtgggctgga tcaacaccta caccggcgag      240

cccacctacg ccgccgactt caagcggcgg ttcaccttct ccctggacac ctccaagtcc      300

accgcctacc tgcagatgaa ctccctgcgg gccgaggaca ccgccgtgta ctactgcgcc      360

aagtaccccc actactacgg ctcctcccac tggtacttcg acgtgtgggg ccagggcacc      420

ctggtgaccg tgtcctccgc ctccaccaag ggcccctccg tgttccccct ggccccctcc      480

tccaagtcca cctccggcgg caccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaactccggc gccctgacct ccggcgtgca caccttcccc      600

gccgtgctgc agtcctccgg cctgtactcc ctgtcctccg tggtgaccgt gccctcctcc      660

tccctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcccaa gtcctgcgac aagacccaca cctgcccccc ctgccccgcc      780

cccgagctgc tgggcggccc ctccgtgttc ctgttccccc ccaagcccaa ggacaccctg      840

atgatctccc ggacccccga ggtgacctgc gtggtggtgg acgtgtccca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc      960

cgggaggagc agtacaactc cacctaccgg gtggtgtccg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgtcca acaaggccct gcccgccccc     1080

atcgagaaga ccatctccaa ggccaagggc cagccccggg agccccaggt gtacaccctg     1140

cccccctccc gggaggagat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagtccaacg gccagcccga gaacaactac     1260

aagaccaccc cccccgtgct ggactccgac ggctccttct tcctgtactc caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttctcct gctccgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagtccctg tccctgtccc ccggcaagtg agcggccgcc     1440


<210>  12
<211>  733
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ranibizumab cDNA (Light chain comprising a signal sequence)

<400>  12
gagctccatg gagtttttca aaaagacggc acttgccgca ctggttatgg gttttagtgg       60

tgcagcattg gccgatatcc agctgaccca gagcccgagc agcctgagcg caagcgttgg      120

tgatcgtgtt accattacct gtagcgcaag ccaggatatt agcaattatc tgaattggta      180

tcagcagaaa ccgggtaaag caccgaaagt tctgatttat tttaccagca gcctgcatag      240

cggtgttccg agccgtttta gcggtagcgg tagtggcacc gattttaccc tgaccattag      300

cagcctgcag ccggaagatt ttgcaaccta ttattgtcag cagtatagca ccgttccgtg      360

gacctttggt cagggcacca aagttgaaat taaacgtacc gttgcagcac cgagcgtttt      420

tatttttccg cctagtgatg aacagctgaa aagcggcacc gcaagcgttg tttgtctgct      480

gaataatttt tatccgcgtg aagcaaaagt gcagtggaaa gttgataatg cactgcagag      540

cggtaatagc caagaaagcg ttaccgaaca ggatagcaaa gatagcacct atagcctgag      600

cagcaccctg accctgagca aagcagatta tgaaaaacac aaagtgtatg cctgcgaagt      660

tacccatcag ggtctgagca gtccggttac caaaagtttt aatcgtggcg aatgctaata      720

gaagcttggt acc                                                         733


<210>  13
<211>  779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ranibizumab cDNA (Heavy chain comprising a signal sequence)

<400>  13
gagctcatat gaaatacctg ctgccgaccg ctgctgctgg tctgctgctc ctcgctgccc       60

agccggcgat ggccgaagtt cagctggttg aaagcggtgg tggtctggtt cagcctggtg      120

gtagcctgcg tctgagctgt gcagcaagcg gttatgattt tacccattat ggtatgaatt      180

gggttcgtca ggcaccgggt aaaggtctgg aatgggttgg ttggattaat acctataccg      240

gtgaaccgac ctatgcagca gattttaaac gtcgttttac ctttagcctg gataccagca      300

aaagcaccgc atatctgcag atgaatagcc tgcgtgcaga agataccgca gtttattatt      360

gtgccaaata tccgtattac tatggcacca gccactggta tttcgatgtt tggggtcagg      420

gcaccctggt taccgttagc agcgcaagca ccaaaggtcc gagcgttttt ccgctggcac      480

cgagcagcaa aagtaccagc ggtggcacag cagcactggg ttgtctggtt aaagattatt      540

ttccggaacc ggttaccgtg agctggaata gcggtgcact gaccagcggt gttcatacct      600

ttccggcagt tctgcagagc agcggtctgt atagcctgag cagcgttgtt accgttccga      660

gcagcagcct gggcacccag acctatattt gtaatgttaa tcataaaccg agcaatacca      720

aagtggataa aaaagttgag ccgaaaagct gcgataaaac ccatctgtaa tagggtacc       779


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab and Ranibizumab Light Chain CDR1

<400>  14

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab and Ranibizumab Light Chain CDR2

<400>  15

Phe Thr Ser Ser Leu His Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab and Ranibizumab Light Chain CDR3

<400>  16

Gln Gln Tyr Ser Thr Val Pro Trp Thr 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab Heavy Chain CDR1

<400>  17

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab Heavy Chain CDR2

<400>  18

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab Heavy Chain CDR3

<400>  19

Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Heavy Chain CDR1

<400>  20

Gly Tyr Asp Phe Thr His Tyr Gly Met Asn 
1               5                   10  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Heavy Chain CDR3

<400>  21

Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin signal peptide

<400>  22

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chymotrypsinogen signal peptide

<400>  23

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Interleukin-2 signal peptide

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trypsinogen-2 signal peptide

<400>  25

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A site

<400>  26

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker T2A

<400>  27

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker P2A

<400>  28

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  29
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker E2A

<400>  29

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker F2A

<400>  30

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<400>  31

Arg Lys Arg Arg 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<400>  32

Arg Arg Arg Arg 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<400>  33

Arg Arg Lys Arg 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<400>  34

Arg Lys Lys Arg 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = Lys or Arg

<400>  35

Arg Xaa Xaa Arg 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = any amino acid

<400>  36

Arg Xaa Lys Arg 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin linker

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = any amino acid

<400>  37

Arg Xaa Arg Arg 
1               


<210>  38
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Fab Amino Acid Sequence - light chain

<400>  38

Met Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  39
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Fab Amino Acid Sequence - heavy chain

<400>  39

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His 
            20                  25                  30          


Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp 
    50                  55                  60                  


Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Leu Arg Lys Arg Arg 
225                 230                 235     


<210>  40
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Fab Amino Acid Sequence - heavy chain

<400>  40

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His 
            20                  25                  30          


Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp 
    50                  55                  60                  


Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Leu 
225                 230         


<210>  41
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV1

<400>  41

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  42
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2

<400>  42

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  43
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV3-3

<400>  43

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  44
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV4-4

<400>  44

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  45
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV5

<400>  45

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  46
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV6

<400>  46

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  47
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV7

<400>  47

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  48
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV8

<400>  48

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  49
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu31

<400>  49

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Gly Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Ser Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  50
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu32

<400>  50

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  51
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9

<400>  51

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  52
<211>  567
<212>  PRT
<213>  Homo sapiens

<220>
<223>  SPERMATOGENESIS ASSOCIATED 7 (SPATA7) <Accession No.: AAH90875.1>

<400>  52

Met Asp Gly Ser Arg Arg Val Arg Ala Thr Ser Val Leu Pro Arg Tyr 
1               5                   10                  15      


Gly Pro Pro Cys Leu Phe Lys Gly His Leu Ser Thr Lys Ser Asn Ala 
            20                  25                  30          


Ala Val Asp Cys Ser Val Pro Val Ser Val Ser Thr Ser Ile Lys Tyr 
        35                  40                  45              


Ala Asp Gln Gln Arg Arg Glu Lys Leu Lys Lys Glu Leu Ala Gln Cys 
    50                  55                  60                  


Glu Lys Glu Phe Lys Leu Thr Lys Thr Ala Met Arg Ala Asn Tyr Lys 
65                  70                  75                  80  


Asn Asn Ser Lys Ser Leu Phe Asn Thr Leu Gln Lys Pro Ser Gly Glu 
                85                  90                  95      


Pro Gln Ile Glu Asp Asp Met Leu Lys Glu Glu Met Asn Gly Phe Ser 
            100                 105                 110         


Ser Phe Ala Arg Ser Leu Val Pro Ser Ser Glu Arg Leu His Leu Ser 
        115                 120                 125             


Leu His Lys Ser Ser Lys Val Ile Thr Asn Gly Pro Glu Lys Asn Ser 
    130                 135                 140                 


Ser Ser Ser Pro Ser Ser Val Asp Tyr Ala Ala Ser Gly Pro Arg Lys 
145                 150                 155                 160 


Leu Ser Ser Gly Ala Leu Tyr Gly Arg Arg Pro Arg Ser Thr Phe Pro 
                165                 170                 175     


Asn Ser His Arg Phe Gln Leu Val Ile Ser Lys Ala Pro Ser Gly Asp 
            180                 185                 190         


Leu Leu Asp Lys His Ser Glu Leu Phe Ser Asn Lys Gln Leu Pro Phe 
        195                 200                 205             


Thr Pro Arg Thr Leu Lys Thr Glu Ala Lys Ser Phe Leu Ser Gln Tyr 
    210                 215                 220                 


Arg Tyr Tyr Thr Pro Ala Lys Arg Lys Lys Asp Phe Thr Asp Gln Arg 
225                 230                 235                 240 


Ile Glu Ala Glu Thr Gln Thr Glu Leu Ser Phe Lys Ser Glu Leu Gly 
                245                 250                 255     


Thr Ala Glu Thr Lys Asn Met Thr Asp Ser Glu Met Asn Ile Lys Gln 
            260                 265                 270         


Ala Ser Asn Cys Val Thr Tyr Asp Ala Lys Glu Lys Ile Ala Pro Leu 
        275                 280                 285             


Pro Leu Glu Gly His Asp Ser Thr Trp Asp Glu Ile Lys Asp Asp Ala 
    290                 295                 300                 


Leu Gln His Ser Ser Pro Arg Ala Met Cys Gln Tyr Ser Leu Lys Pro 
305                 310                 315                 320 


Pro Ser Thr Arg Lys Ile Tyr Ser Asp Glu Glu Glu Leu Leu Tyr Leu 
                325                 330                 335     


Ser Phe Ile Glu Asp Val Thr Asp Glu Ile Leu Lys Leu Gly Leu Phe 
            340                 345                 350         


Ser Asn Arg Phe Leu Glu Arg Leu Phe Glu Arg His Ile Lys Gln Asn 
        355                 360                 365             


Lys His Leu Glu Glu Glu Lys Met Arg His Leu Leu His Val Leu Lys 
    370                 375                 380                 


Val Asp Leu Gly Cys Thr Ser Glu Glu Asn Ser Val Lys Gln Asn Asp 
385                 390                 395                 400 


Val Asp Met Leu Asn Val Phe Asp Phe Glu Lys Ala Gly Asn Ser Glu 
                405                 410                 415     


Pro Asn Glu Leu Lys Asn Glu Ser Glu Val Thr Ile Gln Gln Glu Arg 
            420                 425                 430         


Gln Gln Tyr Gln Lys Ala Leu Asp Met Leu Leu Ser Ala Pro Lys Asp 
        435                 440                 445             


Glu Asn Glu Ile Phe Pro Ser Pro Thr Glu Phe Phe Met Pro Ile Tyr 
    450                 455                 460                 


Lys Ser Lys His Ser Glu Gly Val Ile Ile Gln Gln Val Asn Asp Glu 
465                 470                 475                 480 


Thr Asn Leu Glu Thr Ser Thr Leu Asp Glu Asn His Pro Ser Ile Ser 
                485                 490                 495     


Asp Ser Leu Thr Asp Arg Glu Thr Ser Val Asn Val Ile Glu Gly Asp 
            500                 505                 510         


Ser Asp Pro Glu Lys Val Glu Ile Ser Asn Gly Leu Cys Gly Leu Asn 
        515                 520                 525             


Thr Ser Pro Ser Gln Ser Val Gln Phe Ser Ser Val Lys Gly Asp Asn 
    530                 535                 540                 


Asn His Asp Met Glu Leu Ser Thr Leu Lys Ile Met Glu Met Ser Ile 
545                 550                 555                 560 


Glu Asp Cys Pro Leu Asp Val 
                565         


<210>  53
<211>  697
<212>  PRT
<213>  Homo sapiens

<220>
<223>  LEBERCILIN (LCA5) <Accession No.: NP_001116241.1>

<400>  53

Met Gly Glu Arg Ala Gly Ser Pro Gly Thr Asp Gln Glu Arg Lys Ala 
1               5                   10                  15      


Gly Lys His His Tyr Ser Tyr Leu Ser Asp Phe Glu Thr Pro Gln Ser 
            20                  25                  30          


Ser Gly Arg Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg 
        35                  40                  45              


Lys Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala 
    50                  55                  60                  


Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg 
65                  70                  75                  80  


Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg Lys Asp 
                85                  90                  95      


Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg Leu Leu Lys Ile 
            100                 105                 110         


Asn Glu Leu Gln Asn Glu Val Ser Glu Leu Gln Val Lys Leu Ala Glu 
        115                 120                 125             


Leu Leu Lys Glu Asn Lys Ser Leu Lys Arg Leu Gln Tyr Arg Gln Glu 
    130                 135                 140                 


Lys Ala Leu Asn Lys Phe Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu 
145                 150                 155                 160 


Ile Phe Arg His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg 
                165                 170                 175     


Lys Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr 
            180                 185                 190         


Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu 
        195                 200                 205             


Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala Lys Lys 
    210                 215                 220                 


Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu Arg Arg Ile Lys 
225                 230                 235                 240 


Glu Leu Ser Lys Asn Leu Glu Leu Ser Thr Asn Ser Phe Gln Arg Gln 
                245                 250                 255     


Leu Leu Ala Glu Arg Lys Arg Ala Tyr Glu Ala His Asp Glu Asn Lys 
            260                 265                 270         


Val Leu Gln Lys Glu Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys 
        275                 280                 285             


Glu Arg Glu Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys 
    290                 295                 300                 


Ser Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala 
305                 310                 315                 320 


Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr Met 
                325                 330                 335     


Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu Thr Ile Met 
            340                 345                 350         


Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His Leu Thr Leu Asp Leu 
        355                 360                 365             


Gln Ser Gln Lys Gln Asp Arg His Gly Glu Ala Gly Ile Leu Asn Pro 
    370                 375                 380                 


Ile Met Glu Arg Glu Glu Lys Phe Val Thr Asp Glu Glu Leu His Val 
385                 390                 395                 400 


Val Lys Gln Glu Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu 
                405                 410                 415     


Leu Asp Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu 
            420                 425                 430         


Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile 
        435                 440                 445             


Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys Arg 
    450                 455                 460                 


Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu Leu Gln Asp 
465                 470                 475                 480 


Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro Leu Leu Pro Asp Phe Glu 
                485                 490                 495     


Ser Lys Leu His Ser Pro Glu Arg Ser Pro Lys Thr Tyr Arg Phe Ser 
            500                 505                 510         


Glu Ser Ser Glu Arg Leu Phe Asn Gly His His Leu Gln Asp Ile Ser 
        515                 520                 525             


Phe Ser Thr Pro Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser 
    530                 535                 540                 


Pro Ala Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe 
545                 550                 555                 560 


Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe 
                565                 570                 575     


Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp Gly Val 
            580                 585                 590         


Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu Met Glu Gln Leu 
        595                 600                 605             


Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser Ser Lys Ser Ser Asp Pro 
    610                 615                 620                 


Asn Ser Val Ala Ser Ser Lys Gly Asp Ile Asp Pro Leu Asn Phe Leu 
625                 630                 635                 640 


Pro Gly Asn Lys Gly Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly 
                645                 650                 655     


Phe Phe Leu Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu 
            660                 665                 670         


Lys His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu 
        675                 680                 685             


Asp Glu Ile Glu Glu Val Ala Leu Arg 
    690                 695         


<210>  54
<211>  1286
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RPGR INTERACTING PROTEIN 1 (RPGRIP1) <Accession No.: CAD01135.1>

<400>  54

Met Ser His Leu Val Asp Pro Thr Ser Gly Asp Leu Pro Val Arg Asp 
1               5                   10                  15      


Ile Asp Ala Ile Pro Leu Val Leu Pro Ala Ser Lys Gly Lys Asn Met 
            20                  25                  30          


Lys Thr Gln Pro Pro Leu Ser Arg Met Asn Arg Glu Glu Leu Glu Asp 
        35                  40                  45              


Ser Phe Phe Arg Leu Arg Glu Asp His Met Leu Val Lys Glu Leu Ser 
    50                  55                  60                  


Trp Lys Gln Gln Asp Glu Ile Lys Arg Leu Arg Thr Thr Leu Leu Arg 
65                  70                  75                  80  


Leu Thr Ala Ala Gly Arg Asp Leu Arg Val Ala Glu Glu Ala Ala Pro 
                85                  90                  95      


Leu Ser Glu Thr Ala Arg Arg Gly Gln Lys Ala Gly Trp Arg Gln Arg 
            100                 105                 110         


Leu Ser Met His Gln Arg Pro Gln Met His Arg Leu Gln Gly His Phe 
        115                 120                 125             


His Cys Val Gly Pro Ala Ser Pro Arg Arg Ala Gln Pro Arg Val Gln 
    130                 135                 140                 


Val Gly His Arg Gln Leu His Thr Ala Gly Ala Pro Val Pro Glu Lys 
145                 150                 155                 160 


Pro Lys Arg Gly Pro Arg Asp Arg Leu Ser Tyr Thr Ala Pro Pro Ser 
                165                 170                 175     


Phe Lys Glu His Ala Thr Asn Glu Asn Arg Gly Glu Val Ala Ser Lys 
            180                 185                 190         


Pro Ser Glu Leu Val Ser Gly Ser Asn Ser Ile Ile Ser Phe Ser Ser 
        195                 200                 205             


Val Ile Ser Met Ala Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala 
    210                 215                 220                 


His Ile Met Ala Ser Asn Thr Met Gln Val Glu Glu Pro Pro Lys Ser 
225                 230                 235                 240 


Pro Glu Lys Met Trp Pro Lys Asp Glu Asn Phe Glu Gln Arg Ser Ser 
                245                 250                 255     


Leu Glu Cys Ala Gln Lys Ala Ala Glu Leu Arg Ala Ser Ile Lys Glu 
            260                 265                 270         


Lys Val Glu Leu Ile Arg Leu Lys Lys Leu Leu His Glu Arg Asn Ala 
        275                 280                 285             


Ser Leu Val Met Thr Lys Ala Gln Leu Thr Glu Val Gln Glu Ala Tyr 
    290                 295                 300                 


Glu Thr Leu Leu Gln Lys Asn Gln Gly Ile Leu Ser Ala Ala His Glu 
305                 310                 315                 320 


Ala Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu 
                325                 330                 335     


Ser Lys Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile 
            340                 345                 350         


Leu Gln Met Thr Leu Lys Glu Phe Gln Glu Arg Val Glu Asp Leu Glu 
        355                 360                 365             


Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr Asp Lys Leu Leu Glu Ser 
    370                 375                 380                 


Met Leu Asp Ser Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn Glu 
385                 390                 395                 400 


Leu Ile Ala Glu Gln Leu Gln Gln Gln Val Ser Gln Leu Gln Asp Gln 
                405                 410                 415     


Leu Asp Ala Glu Leu Glu Asp Lys Arg Lys Val Leu Leu Glu Leu Ser 
            420                 425                 430         


Arg Glu Lys Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile 
        435                 440                 445             


Leu Gln Lys His Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala Thr 
    450                 455                 460                 


Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro Ala 
465                 470                 475                 480 


Val Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn Gln 
                485                 490                 495     


Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His 
            500                 505                 510         


Ala Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu 
        515                 520                 525             


Gln Arg Lys Ile Asn Val Cys Tyr Gln Glu Glu Leu Glu Ala Met Met 
    530                 535                 540                 


Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys Glu Lys Leu Glu Arg 
545                 550                 555                 560 


Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu Glu 
                565                 570                 575     


Gly Ile Leu Arg Ser His Asp Leu Pro Thr Ser Glu Gln Leu Lys Asp 
            580                 585                 590         


Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro 
        595                 600                 605             


Ala His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly 
    610                 615                 620                 


Glu Asn Leu Phe Glu Leu His Ile His Gln Ala Phe Leu Thr Ser Ala 
625                 630                 635                 640 


Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro Thr Thr Phe Cys Thr Tyr 
                645                 650                 655     


Ser Phe Tyr Asp Phe Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro 
            660                 665                 670         


Gln Pro Leu Tyr Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser 
        675                 680                 685             


Leu Phe Leu His Tyr Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His 
    690                 695                 700                 


Gln Ala Met Ala Ser Glu His Ser Thr Leu Ala Ala Gly Trp Ile Cys 
705                 710                 715                 720 


Phe Asp Arg Val Leu Glu Thr Val Glu Lys Val His Gly Leu Ala Thr 
                725                 730                 735     


Leu Ile Gly Ala Gly Gly Glu Glu Phe Gly Val Leu Glu Tyr Trp Met 
            740                 745                 750         


Arg Leu Arg Phe Pro Ile Lys Pro Ser Leu Gln Ala Cys Asn Lys Arg 
        755                 760                 765             


Lys Lys Ala Gln Val Tyr Leu Ser Thr Asp Val Leu Gly Gly Arg Lys 
    770                 775                 780                 


Ala Gln Glu Glu Glu Phe Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu 
785                 790                 795                 800 


Leu Trp Ile Glu Ile Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu 
                805                 810                 815     


Gly Thr Gln Pro Ser Pro Tyr Ala Val Tyr Arg Phe Phe Thr Phe Ser 
            820                 825                 830         


Asp His Asp Thr Ala Ile Ile Pro Ala Ser Asn Asn Pro Tyr Phe Arg 
        835                 840                 845             


Asp Gln Ala Arg Phe Pro Val Leu Val Thr Ser Asp Leu Asp His Tyr 
    850                 855                 860                 


Leu Arg Arg Glu Ala Leu Ser Ile His Val Phe Asp Asp Glu Asp Leu 
865                 870                 875                 880 


Glu Pro Gly Ser Tyr Leu Gly Arg Ala Arg Val Pro Leu Leu Pro Leu 
                885                 890                 895     


Ala Lys Asn Glu Ser Ile Lys Gly Asp Phe Asn Leu Thr Asp Pro Ala 
            900                 905                 910         


Glu Lys Pro Asn Gly Ser Ile Gln Val Gln Leu Asp Trp Lys Phe Pro 
        915                 920                 925             


Tyr Ile Pro Pro Glu Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly 
    930                 935                 940                 


Lys Asp Thr Lys Asp Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala 
945                 950                 955                 960 


Ser Phe Pro Ser Gln Asp Gln Met Ala Ser Pro Glu Val Pro Ile Glu 
                965                 970                 975     


Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro Pro His Gly Gly Glu Arg 
            980                 985                 990         


Lys Glu Lys Glu His Gln Val Val  Ser Tyr Ser Arg Arg  Lys His Gly 
        995                 1000                 1005             


Lys Arg  Ile Gly Val Gln Gly  Lys Asn Arg Met Glu  Tyr Leu Ser 
    1010                 1015                 1020             


Leu Asn  Ile Leu Asn Gly Asn  Thr Pro Gln Gln Val  Asn Tyr Thr 
    1025                 1030                 1035             


Glu Trp  Lys Phe Ser Glu Thr  Asn Ser Phe Ile Gly  Asp Gly Phe 
    1040                 1045                 1050             


Lys Asn  Gln His Glu Glu Glu  Glu Met Thr Leu Ser  His Ser Ala 
    1055                 1060                 1065             


Leu Lys  Gln Lys Glu Pro Leu  His Pro Val Asn Asp  Lys Glu Ser 
    1070                 1075                 1080             


Ser Glu  Gln Gly Ser Glu Val  Ser Glu Ala Gln Thr  Thr Asp Ser 
    1085                 1090                 1095             


Asp Asp  Val Ile Val Pro Pro  Met Ser Gln Lys Tyr  Pro Lys Ala 
    1100                 1105                 1110             


Asp Ser  Glu Lys Met Cys Ile  Glu Ile Val Ser Leu  Ala Phe Tyr 
    1115                 1120                 1125             


Pro Glu  Ala Glu Val Met Ser  Asp Glu Asn Ile Lys  Gln Val Tyr 
    1130                 1135                 1140             


Val Glu  Tyr Lys Phe Tyr Asp  Leu Pro Leu Ser Glu  Thr Glu Thr 
    1145                 1150                 1155             


Pro Val  Ser Leu Arg Lys Pro  Arg Ala Gly Glu Glu  Ile His Phe 
    1160                 1165                 1170             


His Phe  Ser Lys Val Ile Asp  Leu Asp Pro Gln Glu  Gln Gln Gly 
    1175                 1180                 1185             


Arg Arg  Arg Phe Leu Phe Asp  Met Leu Asn Gly Gln  Asp Pro Asp 
    1190                 1195                 1200             


Gln Gly  His Leu Lys Phe Thr  Val Val Ser Asp Pro  Leu Asp Glu 
    1205                 1210                 1215             


Glu Lys  Lys Glu Cys Glu Glu  Val Gly Tyr Ala Tyr  Leu Gln Leu 
    1220                 1225                 1230             


Trp Gln  Ile Leu Glu Ser Gly  Arg Asp Ile Leu Glu  Gln Glu Leu 
    1235                 1240                 1245             


Asp Ile  Val Ser Pro Glu Asp  Leu Ala Thr Pro Ile  Gly Arg Leu 
    1250                 1255                 1260             


Lys Val  Ser Leu Gln Ala Ala  Ala Val Leu His Ala  Ile Tyr Lys 
    1265                 1270                 1275             


Glu Met  Thr Glu Asp Leu Phe  Ser 
    1280                 1285     


<210>  55
<211>  299
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CONE-ROD HOMEOBOX (CRX) <Accession No.: EAW57515.1>

<400>  55

Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Thr Gln Tyr Pro 
    50                  55                  60                  


Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu 
65                  70                  75                  80  


Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln 
                85                  90                  95      


Gln Arg Gln Gln Gln Lys Gln Gln Gln Gln Pro Pro Gly Gly Gln Ala 
            100                 105                 110         


Lys Ala Arg Pro Ala Lys Arg Lys Ala Gly Thr Ser Pro Arg Pro Ser 
        115                 120                 125             


Thr Asp Val Cys Pro Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 
    130                 135                 140                 


Pro Leu Pro Gly Pro Ser Gly Ser Pro Thr Thr Ala Val Ala Thr Val 
145                 150                 155                 160 


Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 
                165                 170                 175     


Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Thr Ser Ala Pro Tyr Ala 
            180                 185                 190         


Met Thr Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro Ser Ala Tyr 
        195                 200                 205             


Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp Pro Tyr Leu Ser Pro 
    210                 215                 220                 


Met Val Pro Gln Leu Gly Gly Pro Ala Leu Ser Pro Leu Ser Gly Pro 
225                 230                 235                 240 


Ser Val Gly Pro Ser Leu Ala Gln Ser Pro Thr Ser Leu Ser Gly Gln 
                245                 250                 255     


Ser Tyr Gly Ala Tyr Ser Pro Val Asp Ser Leu Glu Phe Lys Asp Pro 
            260                 265                 270         


Thr Gly Thr Trp Lys Phe Thr Tyr Asn Pro Met Asp Pro Leu Asp Tyr 
        275                 280                 285             


Lys Asp Gln Ser Ala Trp Lys Phe Gln Ile Leu 
    290                 295                 


<210>  56
<211>  1406
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CRUMBS CELL POLARITY COMPLEX COMPONENT 1 (CRB1), HOMOLOG 1 
ISOFORM 1 PRECURSOR <Accession No.: NP_957705.1>

<400>  56

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Thr Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Thr Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Thr Gly Ser Gly Phe Thr Gly Thr His Cys Glu Thr Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Thr Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Thr Cys His Cys Trp Pro Gly Tyr Thr Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
705                 710                 715                 720 


Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr 
                725                 730                 735     


Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu 
            740                 745                 750         


Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
        755                 760                 765             


Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val 
    770                 775                 780                 


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
785                 790                 795                 800 


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
                805                 810                 815     


Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
            820                 825                 830         


Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe 
        835                 840                 845             


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
    850                 855                 860                 


Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
865                 870                 875                 880 


Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
                885                 890                 895     


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
            900                 905                 910         


Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
        915                 920                 925             


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
    930                 935                 940                 


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
945                 950                 955                 960 


Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile 
                965                 970                 975     


Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala 
            980                 985                 990         


Glu Lys Glu Pro Glu Phe Leu Asn  Ile Ser Ile Gln Asp  Ser Arg Leu 
        995                 1000                 1005             


Phe Phe  Gln Leu Gln Ser Gly  Asn Ser Phe Tyr Met  Leu Ser Leu 
    1010                 1015                 1020             


Thr Ser  Leu Gln Ser Val Asn  Asp Gly Thr Trp His  Glu Val Thr 
    1025                 1030                 1035             


Leu Ser  Met Thr Asp Pro Leu  Ser Gln Thr Ser Arg  Trp Gln Met 
    1040                 1045                 1050             


Glu Val  Asp Asn Glu Thr Pro  Phe Val Thr Ser Thr  Ile Ala Thr 
    1055                 1060                 1065             


Gly Ser  Leu Asn Phe Leu Lys  Asp Asn Thr Asp Ile  Tyr Val Gly 
    1070                 1075                 1080             


Asp Arg  Ala Ile Asp Asn Ile  Lys Gly Leu Gln Gly  Cys Leu Ser 
    1085                 1090                 1095             


Thr Ile  Glu Ile Gly Gly Ile  Tyr Leu Ser Tyr Phe  Glu Asn Val 
    1100                 1105                 1110             


His Gly  Phe Ile Asn Lys Pro  Gln Glu Glu Gln Phe  Leu Lys Ile 
    1115                 1120                 1125             


Ser Thr  Asn Ser Val Val Thr  Gly Cys Leu Gln Leu  Asn Val Cys 
    1130                 1135                 1140             


Asn Ser  Asn Pro Cys Leu His  Gly Gly Asn Cys Glu  Asp Ile Tyr 
    1145                 1150                 1155             


Ser Ser  Tyr His Cys Ser Cys  Pro Leu Gly Trp Ser  Gly Lys His 
    1160                 1165                 1170             


Cys Glu  Leu Asn Ile Asp Glu  Cys Phe Ser Asn Pro  Cys Ile His 
    1175                 1180                 1185             


Gly Asn  Cys Ser Asp Arg Val  Ala Ala Tyr His Cys  Thr Cys Glu 
    1190                 1195                 1200             


Pro Gly  Tyr Thr Gly Val Asn  Cys Glu Val Asp Ile  Asp Asn Cys 
    1205                 1210                 1215             


Gln Ser  His Gln Cys Ala Asn  Gly Ala Thr Cys Ile  Ser His Thr 
    1220                 1225                 1230             


Asn Gly  Tyr Ser Cys Leu Cys  Phe Gly Asn Phe Thr  Gly Lys Phe 
    1235                 1240                 1245             


Cys Arg  Gln Ser Arg Leu Pro  Ser Thr Val Cys Gly  Asn Glu Lys 
    1250                 1255                 1260             


Thr Asn  Leu Thr Cys Tyr Asn  Gly Gly Asn Cys Thr  Glu Phe Gln 
    1265                 1270                 1275             


Thr Glu  Leu Lys Cys Met Cys  Arg Pro Gly Phe Thr  Gly Glu Trp 
    1280                 1285                 1290             


Cys Glu  Lys Asp Ile Asp Glu  Cys Ala Ser Asp Pro  Cys Val Asn 
    1295                 1300                 1305             


Gly Gly  Leu Cys Gln Asp Leu  Leu Asn Lys Phe Gln  Cys Leu Cys 
    1310                 1315                 1320             


Asp Val  Ala Phe Ala Gly Glu  Arg Cys Glu Val Asp  Leu Ala Asp 
    1325                 1330                 1335             


Asp Leu  Ile Ser Asp Ile Phe  Thr Thr Ile Gly Ser  Val Thr Val 
    1340                 1345                 1350             


Ala Leu  Leu Leu Ile Leu Leu  Leu Ala Ile Val Ala  Ser Val Val 
    1355                 1360                 1365             


Thr Ser  Asn Lys Arg Ala Thr  Gln Gly Thr Tyr Ser  Pro Ser Arg 
    1370                 1375                 1380             


Gln Glu  Lys Glu Gly Ser Arg  Val Glu Met Trp Asn  Leu Met Pro 
    1385                 1390                 1395             


Pro Pro  Ala Met Glu Arg Leu  Ile 
    1400                 1405     


<210>  57
<211>  1294
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CRUMBS CELL POLARITY COMPLEX COMPONENT 1 (CRB1), HOMOLOG 1 
ISOFORM 2 PRECURSOR <Accession No.: NP_001180569.1>

<400>  57

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Tyr Thr Gly Ala Gln Cys 
    210                 215                 220                 


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
225                 230                 235                 240 


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
                245                 250                 255     


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
            260                 265                 270         


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
        275                 280                 285             


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
    290                 295                 300                 


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
305                 310                 315                 320 


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
                325                 330                 335     


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
            340                 345                 350         


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
        355                 360                 365             


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
    370                 375                 380                 


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
385                 390                 395                 400 


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
                405                 410                 415     


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
            420                 425                 430         


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
        435                 440                 445             


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
    450                 455                 460                 


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
465                 470                 475                 480 


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
                485                 490                 495     


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
            500                 505                 510         


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
        515                 520                 525             


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
    530                 535                 540                 


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
545                 550                 555                 560 


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
                565                 570                 575     


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
            580                 585                 590         


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
        595                 600                 605             


Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr 
    610                 615                 620                 


Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu 
625                 630                 635                 640 


Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
                645                 650                 655     


Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val 
            660                 665                 670         


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
        675                 680                 685             


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
    690                 695                 700                 


Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
705                 710                 715                 720 


Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe 
                725                 730                 735     


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
            740                 745                 750         


Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
        755                 760                 765             


Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
    770                 775                 780                 


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
785                 790                 795                 800 


Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
                805                 810                 815     


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
            820                 825                 830         


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
        835                 840                 845             


Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile 
    850                 855                 860                 


Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala 
865                 870                 875                 880 


Glu Lys Glu Pro Glu Phe Leu Asn Ile Ser Ile Gln Asp Ser Arg Leu 
                885                 890                 895     


Phe Phe Gln Leu Gln Ser Gly Asn Ser Phe Tyr Met Leu Ser Leu Thr 
            900                 905                 910         


Ser Leu Gln Ser Val Asn Asp Gly Thr Trp His Glu Val Thr Leu Ser 
        915                 920                 925             


Met Thr Asp Pro Leu Ser Gln Thr Ser Arg Trp Gln Met Glu Val Asp 
    930                 935                 940                 


Asn Glu Thr Pro Phe Val Thr Ser Thr Ile Ala Thr Gly Ser Leu Asn 
945                 950                 955                 960 


Phe Leu Lys Asp Asn Thr Asp Ile Tyr Val Gly Asp Arg Ala Ile Asp 
                965                 970                 975     


Asn Ile Lys Gly Leu Gln Gly Cys Leu Ser Thr Ile Glu Ile Gly Gly 
            980                 985                 990         


Ile Tyr Leu Ser Tyr Phe Glu Asn  Val His Gly Phe Ile  Asn Lys Pro 
        995                 1000                 1005             


Gln Glu  Glu Gln Phe Leu Lys  Ile Ser Thr Asn Ser  Val Val Thr 
    1010                 1015                 1020             


Gly Cys  Leu Gln Leu Asn Val  Cys Asn Ser Asn Pro  Cys Leu His 
    1025                 1030                 1035             


Gly Gly  Asn Cys Glu Asp Ile  Tyr Ser Ser Tyr His  Cys Ser Cys 
    1040                 1045                 1050             


Pro Leu  Gly Trp Ser Gly Lys  His Cys Glu Leu Asn  Ile Asp Glu 
    1055                 1060                 1065             


Cys Phe  Ser Asn Pro Cys Ile  His Gly Asn Cys Ser  Asp Arg Val 
    1070                 1075                 1080             


Ala Ala  Tyr His Cys Thr Cys  Glu Pro Gly Tyr Thr  Gly Val Asn 
    1085                 1090                 1095             


Cys Glu  Val Asp Ile Asp Asn  Cys Gln Ser His Gln  Cys Ala Asn 
    1100                 1105                 1110             


Gly Ala  Thr Cys Ile Ser His  Thr Asn Gly Tyr Ser  Cys Leu Cys 
    1115                 1120                 1125             


Phe Gly  Asn Phe Thr Gly Lys  Phe Cys Arg Gln Ser  Arg Leu Pro 
    1130                 1135                 1140             


Ser Thr  Val Cys Gly Asn Glu  Lys Thr Asn Leu Thr  Cys Tyr Asn 
    1145                 1150                 1155             


Gly Gly  Asn Cys Thr Glu Phe  Gln Thr Glu Leu Lys  Cys Met Cys 
    1160                 1165                 1170             


Arg Pro  Gly Phe Thr Gly Glu  Trp Cys Glu Lys Asp  Ile Asp Glu 
    1175                 1180                 1185             


Cys Ala  Ser Asp Pro Cys Val  Asn Gly Gly Leu Cys  Gln Asp Leu 
    1190                 1195                 1200             


Leu Asn  Lys Phe Gln Cys Leu  Cys Asp Val Ala Phe  Ala Gly Glu 
    1205                 1210                 1215             


Arg Cys  Glu Val Asp Leu Ala  Asp Asp Leu Ile Ser  Asp Ile Phe 
    1220                 1225                 1230             


Thr Thr  Ile Gly Ser Val Thr  Val Ala Leu Leu Leu  Ile Leu Leu 
    1235                 1240                 1245             


Leu Ala  Ile Val Ala Ser Val  Val Thr Ser Asn Lys  Arg Ala Thr 
    1250                 1255                 1260             


Gln Gly  Thr Tyr Ser Pro Ser  Arg Gln Glu Lys Glu  Gly Ser Arg 
    1265                 1270                 1275             


Val Glu  Met Trp Asn Leu Met  Pro Pro Pro Ala Met  Glu Arg Leu 
    1280                 1285                 1290             


Ile 
    


<210>  58
<211>  279
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE 1 (NMNAT1) 
<Accession No.: Q9HAN9.1>

<400>  58

Met Glu Asn Ser Glu Lys Thr Glu Val Val Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys 
            20                  25                  30          


Asp Tyr Met Asn Gly Thr Gly Arg Tyr Thr Val Val Lys Gly Ile Ile 
        35                  40                  45              


Ser Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Pro Ala Tyr 
    50                  55                  60                  


His Arg Val Ile Met Ala Glu Leu Ala Thr Lys Asn Ser Lys Trp Val 
65                  70                  75                  80  


Glu Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Lys Glu Thr Leu 
                85                  90                  95      


Lys Val Leu Arg His His Gln Glu Lys Leu Glu Ala Ser Asp Cys Asp 
            100                 105                 110         


His Gln Gln Asn Ser Pro Thr Leu Glu Arg Pro Gly Arg Lys Arg Lys 
        115                 120                 125             


Trp Thr Glu Thr Gln Asp Ser Ser Gln Lys Lys Ser Leu Glu Pro Lys 
    130                 135                 140                 


Thr Lys Ala Val Pro Lys Val Lys Leu Leu Cys Gly Ala Asp Leu Leu 
145                 150                 155                 160 


Glu Ser Phe Ala Val Pro Asn Leu Trp Lys Ser Glu Asp Ile Thr Gln 
                165                 170                 175     


Ile Val Ala Asn Tyr Gly Leu Ile Cys Val Thr Arg Ala Gly Asn Asp 
            180                 185                 190         


Ala Gln Lys Phe Ile Tyr Glu Ser Asp Val Leu Trp Lys His Arg Ser 
        195                 200                 205             


Asn Ile His Val Val Asn Glu Trp Ile Ala Asn Asp Ile Ser Ser Thr 
    210                 215                 220                 


Lys Ile Arg Arg Ala Leu Arg Arg Gly Gln Ser Ile Arg Tyr Leu Val 
225                 230                 235                 240 


Pro Asp Leu Val Gln Glu Tyr Ile Glu Lys His Asn Leu Tyr Ser Ser 
                245                 250                 255     


Glu Ser Glu Asp Arg Asn Ala Gly Val Ile Leu Ala Pro Leu Gln Arg 
            260                 265                 270         


Asn Thr Ala Glu Ala Lys Thr 
        275                 


<210>  59
<211>  279
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE 1 (NMNAT1); 
ISOFORM CRA_A <Accession No.: EAW71635.1>

<400>  59

Met Glu Asn Ser Glu Lys Thr Glu Val Val Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys 
            20                  25                  30          


Asp Tyr Met Asn Gly Thr Gly Arg Tyr Thr Val Val Lys Gly Ile Ile 
        35                  40                  45              


Ser Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Pro Ala Tyr 
    50                  55                  60                  


His Arg Val Ile Met Ala Glu Leu Ala Thr Lys Asn Ser Lys Trp Val 
65                  70                  75                  80  


Glu Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Lys Glu Thr Leu 
                85                  90                  95      


Lys Val Leu Arg His His Gln Glu Lys Leu Glu Ala Ser Asp Cys Asp 
            100                 105                 110         


His Gln Gln Asn Ser Pro Thr Leu Glu Arg Pro Gly Arg Lys Arg Lys 
        115                 120                 125             


Trp Thr Glu Thr Gln Asp Ser Ser Gln Lys Lys Ser Leu Glu Pro Lys 
    130                 135                 140                 


Thr Lys Ala Val Pro Lys Val Lys Leu Leu Cys Gly Ala Asp Leu Leu 
145                 150                 155                 160 


Glu Ser Phe Ala Val Pro Asn Leu Trp Lys Ser Glu Asp Ile Thr Gln 
                165                 170                 175     


Ile Val Ala Asn Tyr Gly Leu Ile Cys Val Thr Arg Ala Gly Asn Asp 
            180                 185                 190         


Ala Gln Lys Phe Ile Tyr Glu Ser Asp Val Leu Trp Lys His Arg Ser 
        195                 200                 205             


Asn Ile His Val Val Asn Glu Trp Ile Ala Asn Asp Ile Ser Ser Thr 
    210                 215                 220                 


Lys Ile Arg Arg Ala Leu Arg Arg Gly Gln Ser Ile Arg Tyr Leu Val 
225                 230                 235                 240 


Pro Asp Leu Val Gln Glu Tyr Ile Glu Lys His Asn Leu Tyr Ser Ser 
                245                 250                 255     


Glu Ser Glu Asp Arg Asn Ala Gly Val Ile Leu Ala Pro Leu Gln Arg 
            260                 265                 270         


Asn Thr Ala Glu Ala Lys Thr 
        275                 


<210>  60
<211>  160
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE 1 (NMNAT1), 
ISOFORM 2 <Accession No.: NP_001284708.1>

<400>  60

Met Glu Asn Ser Glu Lys Thr Glu Val Val Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys 
            20                  25                  30          


Asp Tyr Met Asn Gly Thr Gly Arg Tyr Thr Val Val Lys Gly Ile Ile 
        35                  40                  45              


Ser Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Pro Ala Tyr 
    50                  55                  60                  


His Arg Val Ile Met Ala Glu Leu Ala Thr Lys Asn Ser Lys Trp Val 
65                  70                  75                  80  


Glu Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Lys Glu Thr Leu 
                85                  90                  95      


Lys Val Leu Arg His His Gln Glu Lys Leu Glu Ala Ser Asp Cys Asp 
            100                 105                 110         


His Gln Gln Asn Ser Pro Thr Leu Glu Arg Pro Gly Arg Lys Arg Lys 
        115                 120                 125             


Trp Thr Glu Thr Gln Asp Ser Ser Gln Lys Lys Ser Leu Glu Pro Lys 
    130                 135                 140                 


Thr Lys Asp Gly Val Ser Leu Tyr His Pro Gly Trp Ser Ala Val Ala 
145                 150                 155                 160 


<210>  61
<211>  279
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE 1 (NMNAT1), 
ISOFORM 1 <Accession No.: NP_073624.2>

<400>  61

Met Glu Asn Ser Glu Lys Thr Glu Val Val Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys 
            20                  25                  30          


Asp Tyr Met Asn Gly Thr Gly Arg Tyr Thr Val Val Lys Gly Ile Ile 
        35                  40                  45              


Ser Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Pro Ala Tyr 
    50                  55                  60                  


His Arg Val Ile Met Ala Glu Leu Ala Thr Lys Asn Ser Lys Trp Val 
65                  70                  75                  80  


Glu Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Lys Glu Thr Leu 
                85                  90                  95      


Lys Val Leu Arg His His Gln Glu Lys Leu Glu Ala Ser Asp Cys Asp 
            100                 105                 110         


His Gln Gln Asn Ser Pro Thr Leu Glu Arg Pro Gly Arg Lys Arg Lys 
        115                 120                 125             


Trp Thr Glu Thr Gln Asp Ser Ser Gln Lys Lys Ser Leu Glu Pro Lys 
    130                 135                 140                 


Thr Lys Ala Val Pro Lys Val Lys Leu Leu Cys Gly Ala Asp Leu Leu 
145                 150                 155                 160 


Glu Ser Phe Ala Val Pro Asn Leu Trp Lys Ser Glu Asp Ile Thr Gln 
                165                 170                 175     


Ile Val Ala Asn Tyr Gly Leu Ile Cys Val Thr Arg Ala Gly Asn Asp 
            180                 185                 190         


Ala Gln Lys Phe Ile Tyr Glu Ser Asp Val Leu Trp Lys His Arg Ser 
        195                 200                 205             


Asn Ile His Val Val Asn Glu Trp Ile Ala Asn Asp Ile Ser Ser Thr 
    210                 215                 220                 


Lys Ile Arg Arg Ala Leu Arg Arg Gly Gln Ser Ile Arg Tyr Leu Val 
225                 230                 235                 240 


Pro Asp Leu Val Gln Glu Tyr Ile Glu Lys His Asn Leu Tyr Ser Ser 
                245                 250                 255     


Glu Ser Glu Asp Arg Asn Ala Gly Val Ile Leu Ala Pro Leu Gln Arg 
            260                 265                 270         


Asn Thr Ala Glu Ala Lys Thr 
        275                 


<210>  62
<211>  2479
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290); <Accession No.: NP_079390.3>

<400>  62

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  63
<211>  2769
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X1 <Accession No.: 
XP_011537059.1>

<400>  63

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Gln Asn Gln  Ile Ser Gly Ile Glu  Ser Asp Asp 
    2330                 2335                 2340             


His Cys  Gln Arg Glu Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu 
    2345                 2350                 2355             


Ser Ser  Glu Asn Ile Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn 
    2360                 2365                 2370             


Lys Asp  Leu Pro Arg Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu 
    2375                 2380                 2385             


Met Cys  Glu Phe Leu Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys 
    2390                 2395                 2400             


Leu Gly  His Val Arg Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro 
    2405                 2410                 2415             


Glu Leu  Glu Lys Thr Ile Gly  Leu Met Lys Lys Val  Val Glu Lys 
    2420                 2425                 2430             


Val Gln  Arg Glu Asn Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu 
    2435                 2440                 2445             


Thr Ser  Glu Lys Met Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu 
    2450                 2455                 2460             


Lys Ala  Glu Leu Glu Lys Leu  Lys Ala His Leu Gly  His Gln Leu 
    2465                 2470                 2475             


Ser Met  His Tyr Glu Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile 
    2480                 2485                 2490             


Ala Glu  Asn Glu Arg Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp 
    2495                 2500                 2505             


Ala Ala  Glu Lys Leu Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu 
    2510                 2515                 2520             


Asn Glu  Lys Met Thr Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu 
    2525                 2530                 2535             


Gln Phe  Ala Glu Ser Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser 
    2540                 2545                 2550             


Lys Ser  Trp Lys Ser Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys 
    2555                 2560                 2565             


Leu Lys  Glu Leu Glu Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile 
    2570                 2575                 2580             


Thr Asp  Leu Lys Gln Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln 
    2585                 2590                 2595             


Lys Val  Asn Lys Tyr Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile 
    2600                 2605                 2610             


Leu Lys  His Val Pro Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys 
    2615                 2620                 2625             


Arg Glu  Leu Gln Val Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys 
    2630                 2635                 2640             


Glu Lys  Ala Glu Leu Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln 
    2645                 2650                 2655             


Ser Gly  Ala Glu Ser Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu 
    2660                 2665                 2670             


Lys Ile  Lys Asp Leu Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu 
    2675                 2680                 2685             


Lys Gln  His Leu Lys Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu 
    2690                 2695                 2700             


Glu Asn  Phe Asp Pro Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys 
    2705                 2710                 2715             


Tyr Asn  Tyr Lys Glu Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu 
    2720                 2725                 2730             


Lys Val  Lys Lys Leu Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser 
    2735                 2740                 2745             


Pro Val  Ala Ala Ser Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro 
    2750                 2755                 2760             


Val Asn  Phe Pro Ile Tyr 
    2765                 


<210>  64
<211>  2768
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X2 <Accession No.: 
XP_011537060.1>

<400>  64

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Asn Gln Ile  Ser Gly Ile Glu Ser  Asp Asp His 
    2330                 2335                 2340             


Cys Gln  Arg Glu Gln Glu Leu  Gln Lys Glu Asn Leu  Lys Leu Ser 
    2345                 2350                 2355             


Ser Glu  Asn Ile Glu Leu Lys  Phe Gln Leu Glu Gln  Ala Asn Lys 
    2360                 2365                 2370             


Asp Leu  Pro Arg Leu Lys Asn  Gln Val Arg Asp Leu  Lys Glu Met 
    2375                 2380                 2385             


Cys Glu  Phe Leu Lys Lys Glu  Lys Ala Glu Val Gln  Arg Lys Leu 
    2390                 2395                 2400             


Gly His  Val Arg Gly Ser Gly  Arg Ser Gly Lys Thr  Ile Pro Glu 
    2405                 2410                 2415             


Leu Glu  Lys Thr Ile Gly Leu  Met Lys Lys Val Val  Glu Lys Val 
    2420                 2425                 2430             


Gln Arg  Glu Asn Glu Gln Leu  Lys Lys Ala Ser Gly  Ile Leu Thr 
    2435                 2440                 2445             


Ser Glu  Lys Met Ala Asn Ile  Glu Gln Glu Asn Glu  Lys Leu Lys 
    2450                 2455                 2460             


Ala Glu  Leu Glu Lys Leu Lys  Ala His Leu Gly His  Gln Leu Ser 
    2465                 2470                 2475             


Met His  Tyr Glu Ser Lys Thr  Lys Gly Thr Glu Lys  Ile Ile Ala 
    2480                 2485                 2490             


Glu Asn  Glu Arg Leu Arg Lys  Glu Leu Lys Lys Glu  Thr Asp Ala 
    2495                 2500                 2505             


Ala Glu  Lys Leu Arg Ile Ala  Lys Asn Asn Leu Glu  Ile Leu Asn 
    2510                 2515                 2520             


Glu Lys  Met Thr Val Gln Leu  Glu Glu Thr Gly Lys  Arg Leu Gln 
    2525                 2530                 2535             


Phe Ala  Glu Ser Arg Gly Pro  Gln Leu Glu Gly Ala  Asp Ser Lys 
    2540                 2545                 2550             


Ser Trp  Lys Ser Ile Val Val  Thr Arg Met Tyr Glu  Thr Lys Leu 
    2555                 2560                 2565             


Lys Glu  Leu Glu Thr Asp Ile  Ala Lys Lys Asn Gln  Ser Ile Thr 
    2570                 2575                 2580             


Asp Leu  Lys Gln Leu Val Lys  Glu Ala Thr Glu Arg  Glu Gln Lys 
    2585                 2590                 2595             


Val Asn  Lys Tyr Asn Glu Asp  Leu Glu Gln Gln Ile  Lys Ile Leu 
    2600                 2605                 2610             


Lys His  Val Pro Glu Gly Ala  Glu Thr Glu Gln Gly  Leu Lys Arg 
    2615                 2620                 2625             


Glu Leu  Gln Val Leu Arg Leu  Ala Asn His Gln Leu  Asp Lys Glu 
    2630                 2635                 2640             


Lys Ala  Glu Leu Ile His Gln  Ile Glu Ala Asn Lys  Asp Gln Ser 
    2645                 2650                 2655             


Gly Ala  Glu Ser Thr Ile Pro  Asp Ala Asp Gln Leu  Lys Glu Lys 
    2660                 2665                 2670             


Ile Lys  Asp Leu Glu Thr Gln  Leu Lys Met Ser Asp  Leu Glu Lys 
    2675                 2680                 2685             


Gln His  Leu Lys Glu Glu Ile  Lys Lys Leu Lys Lys  Glu Leu Glu 
    2690                 2695                 2700             


Asn Phe  Asp Pro Ser Phe Phe  Glu Glu Ile Glu Asp  Leu Lys Tyr 
    2705                 2710                 2715             


Asn Tyr  Lys Glu Glu Val Lys  Lys Asn Ile Leu Leu  Glu Glu Lys 
    2720                 2725                 2730             


Val Lys  Lys Leu Ser Glu Gln  Leu Gly Val Glu Leu  Thr Ser Pro 
    2735                 2740                 2745             


Val Ala  Ala Ser Glu Glu Phe  Glu Asp Glu Glu Glu  Ser Pro Val 
    2750                 2755                 2760             


Asn Phe  Pro Ile Tyr 
    2765             


<210>  65
<211>  2766
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X3 <Accession No.: 
XP_011537061.1>

<400>  65

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Ile Ser Gly  Ile Glu Ser Asp Asp  His Cys Gln 
    2330                 2335                 2340             


Arg Glu  Gln Glu Leu Gln Lys  Glu Asn Leu Lys Leu  Ser Ser Glu 
    2345                 2350                 2355             


Asn Ile  Glu Leu Lys Phe Gln  Leu Glu Gln Ala Asn  Lys Asp Leu 
    2360                 2365                 2370             


Pro Arg  Leu Lys Asn Gln Val  Arg Asp Leu Lys Glu  Met Cys Glu 
    2375                 2380                 2385             


Phe Leu  Lys Lys Glu Lys Ala  Glu Val Gln Arg Lys  Leu Gly His 
    2390                 2395                 2400             


Val Arg  Gly Ser Gly Arg Ser  Gly Lys Thr Ile Pro  Glu Leu Glu 
    2405                 2410                 2415             


Lys Thr  Ile Gly Leu Met Lys  Lys Val Val Glu Lys  Val Gln Arg 
    2420                 2425                 2430             


Glu Asn  Glu Gln Leu Lys Lys  Ala Ser Gly Ile Leu  Thr Ser Glu 
    2435                 2440                 2445             


Lys Met  Ala Asn Ile Glu Gln  Glu Asn Glu Lys Leu  Lys Ala Glu 
    2450                 2455                 2460             


Leu Glu  Lys Leu Lys Ala His  Leu Gly His Gln Leu  Ser Met His 
    2465                 2470                 2475             


Tyr Glu  Ser Lys Thr Lys Gly  Thr Glu Lys Ile Ile  Ala Glu Asn 
    2480                 2485                 2490             


Glu Arg  Leu Arg Lys Glu Leu  Lys Lys Glu Thr Asp  Ala Ala Glu 
    2495                 2500                 2505             


Lys Leu  Arg Ile Ala Lys Asn  Asn Leu Glu Ile Leu  Asn Glu Lys 
    2510                 2515                 2520             


Met Thr  Val Gln Leu Glu Glu  Thr Gly Lys Arg Leu  Gln Phe Ala 
    2525                 2530                 2535             


Glu Ser  Arg Gly Pro Gln Leu  Glu Gly Ala Asp Ser  Lys Ser Trp 
    2540                 2545                 2550             


Lys Ser  Ile Val Val Thr Arg  Met Tyr Glu Thr Lys  Leu Lys Glu 
    2555                 2560                 2565             


Leu Glu  Thr Asp Ile Ala Lys  Lys Asn Gln Ser Ile  Thr Asp Leu 
    2570                 2575                 2580             


Lys Gln  Leu Val Lys Glu Ala  Thr Glu Arg Glu Gln  Lys Val Asn 
    2585                 2590                 2595             


Lys Tyr  Asn Glu Asp Leu Glu  Gln Gln Ile Lys Ile  Leu Lys His 
    2600                 2605                 2610             


Val Pro  Glu Gly Ala Glu Thr  Glu Gln Gly Leu Lys  Arg Glu Leu 
    2615                 2620                 2625             


Gln Val  Leu Arg Leu Ala Asn  His Gln Leu Asp Lys  Glu Lys Ala 
    2630                 2635                 2640             


Glu Leu  Ile His Gln Ile Glu  Ala Asn Lys Asp Gln  Ser Gly Ala 
    2645                 2650                 2655             


Glu Ser  Thr Ile Pro Asp Ala  Asp Gln Leu Lys Glu  Lys Ile Lys 
    2660                 2665                 2670             


Asp Leu  Glu Thr Gln Leu Lys  Met Ser Asp Leu Glu  Lys Gln His 
    2675                 2680                 2685             


Leu Lys  Glu Glu Ile Lys Lys  Leu Lys Lys Glu Leu  Glu Asn Phe 
    2690                 2695                 2700             


Asp Pro  Ser Phe Phe Glu Glu  Ile Glu Asp Leu Lys  Tyr Asn Tyr 
    2705                 2710                 2715             


Lys Glu  Glu Val Lys Lys Asn  Ile Leu Leu Glu Glu  Lys Val Lys 
    2720                 2725                 2730             


Lys Leu  Ser Glu Gln Leu Gly  Val Glu Leu Thr Ser  Pro Val Ala 
    2735                 2740                 2745             


Ala Ser  Glu Glu Phe Glu Asp  Glu Glu Glu Ser Pro  Val Asn Phe 
    2750                 2755                 2760             


Pro Ile  Tyr 
    2765     


<210>  66
<211>  2728
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X4 <Accession No.: 
XP_011537062.1>

<400>  66

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Gln Asn Gln  Ile Ser Gly Ile Glu  Ser Asp Asp 
    2330                 2335                 2340             


His Cys  Gln Arg Glu Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu 
    2345                 2350                 2355             


Ser Ser  Glu Asn Ile Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn 
    2360                 2365                 2370             


Lys Asp  Leu Pro Arg Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu 
    2375                 2380                 2385             


Met Cys  Glu Phe Leu Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys 
    2390                 2395                 2400             


Leu Gly  His Val Arg Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro 
    2405                 2410                 2415             


Glu Leu  Glu Lys Thr Ile Gly  Leu Met Lys Lys Val  Val Glu Lys 
    2420                 2425                 2430             


Val Gln  Arg Glu Asn Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu 
    2435                 2440                 2445             


Thr Ser  Glu Lys Met Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu 
    2450                 2455                 2460             


Lys Glu  Thr Asp Ala Ala Glu  Lys Leu Arg Ile Ala  Lys Asn Asn 
    2465                 2470                 2475             


Leu Glu  Ile Leu Asn Glu Lys  Met Thr Val Gln Leu  Glu Glu Thr 
    2480                 2485                 2490             


Gly Lys  Arg Leu Gln Phe Ala  Glu Ser Arg Gly Pro  Gln Leu Glu 
    2495                 2500                 2505             


Gly Ala  Asp Ser Lys Ser Trp  Lys Ser Ile Val Val  Thr Arg Met 
    2510                 2515                 2520             


Tyr Glu  Thr Lys Leu Lys Glu  Leu Glu Thr Asp Ile  Ala Lys Lys 
    2525                 2530                 2535             


Asn Gln  Ser Ile Thr Asp Leu  Lys Gln Leu Val Lys  Glu Ala Thr 
    2540                 2545                 2550             


Glu Arg  Glu Gln Lys Val Asn  Lys Tyr Asn Glu Asp  Leu Glu Gln 
    2555                 2560                 2565             


Gln Ile  Lys Ile Leu Lys His  Val Pro Glu Gly Ala  Glu Thr Glu 
    2570                 2575                 2580             


Gln Gly  Leu Lys Arg Glu Leu  Gln Val Leu Arg Leu  Ala Asn His 
    2585                 2590                 2595             


Gln Leu  Asp Lys Glu Lys Ala  Glu Leu Ile His Gln  Ile Glu Ala 
    2600                 2605                 2610             


Asn Lys  Asp Gln Ser Gly Ala  Glu Ser Thr Ile Pro  Asp Ala Asp 
    2615                 2620                 2625             


Gln Leu  Lys Glu Lys Ile Lys  Asp Leu Glu Thr Gln  Leu Lys Met 
    2630                 2635                 2640             


Ser Asp  Leu Glu Lys Gln His  Leu Lys Glu Glu Ile  Lys Lys Leu 
    2645                 2650                 2655             


Lys Lys  Glu Leu Glu Asn Phe  Asp Pro Ser Phe Phe  Glu Glu Ile 
    2660                 2665                 2670             


Glu Asp  Leu Lys Tyr Asn Tyr  Lys Glu Glu Val Lys  Lys Asn Ile 
    2675                 2680                 2685             


Leu Leu  Glu Glu Lys Val Lys  Lys Leu Ser Glu Gln  Leu Gly Val 
    2690                 2695                 2700             


Glu Leu  Thr Ser Pro Val Ala  Ala Ser Glu Glu Phe  Glu Asp Glu 
    2705                 2710                 2715             


Glu Glu  Ser Pro Val Asn Phe  Pro Ile Tyr 
    2720                 2725             


<210>  67
<211>  2725
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X5 <Accession 
No.: XP_016875469.1>

<400>  67

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Ile Ser Gly  Ile Glu Ser Asp Asp  His Cys Gln 
    2330                 2335                 2340             


Arg Glu  Gln Glu Leu Gln Lys  Glu Asn Leu Lys Leu  Ser Ser Glu 
    2345                 2350                 2355             


Asn Ile  Glu Leu Lys Phe Gln  Leu Glu Gln Ala Asn  Lys Asp Leu 
    2360                 2365                 2370             


Pro Arg  Leu Lys Asn Gln Val  Arg Asp Leu Lys Glu  Met Cys Glu 
    2375                 2380                 2385             


Phe Leu  Lys Lys Glu Lys Ala  Glu Val Gln Arg Lys  Leu Gly His 
    2390                 2395                 2400             


Val Arg  Gly Ser Gly Arg Ser  Gly Lys Thr Ile Pro  Glu Leu Glu 
    2405                 2410                 2415             


Lys Thr  Ile Gly Leu Met Lys  Lys Val Val Glu Lys  Val Gln Arg 
    2420                 2425                 2430             


Glu Asn  Glu Gln Leu Lys Lys  Ala Ser Gly Ile Leu  Thr Ser Glu 
    2435                 2440                 2445             


Lys Met  Ala Asn Ile Glu Gln  Glu Asn Glu Lys Leu  Lys Glu Thr 
    2450                 2455                 2460             


Asp Ala  Ala Glu Lys Leu Arg  Ile Ala Lys Asn Asn  Leu Glu Ile 
    2465                 2470                 2475             


Leu Asn  Glu Lys Met Thr Val  Gln Leu Glu Glu Thr  Gly Lys Arg 
    2480                 2485                 2490             


Leu Gln  Phe Ala Glu Ser Arg  Gly Pro Gln Leu Glu  Gly Ala Asp 
    2495                 2500                 2505             


Ser Lys  Ser Trp Lys Ser Ile  Val Val Thr Arg Met  Tyr Glu Thr 
    2510                 2515                 2520             


Lys Leu  Lys Glu Leu Glu Thr  Asp Ile Ala Lys Lys  Asn Gln Ser 
    2525                 2530                 2535             


Ile Thr  Asp Leu Lys Gln Leu  Val Lys Glu Ala Thr  Glu Arg Glu 
    2540                 2545                 2550             


Gln Lys  Val Asn Lys Tyr Asn  Glu Asp Leu Glu Gln  Gln Ile Lys 
    2555                 2560                 2565             


Ile Leu  Lys His Val Pro Glu  Gly Ala Glu Thr Glu  Gln Gly Leu 
    2570                 2575                 2580             


Lys Arg  Glu Leu Gln Val Leu  Arg Leu Ala Asn His  Gln Leu Asp 
    2585                 2590                 2595             


Lys Glu  Lys Ala Glu Leu Ile  His Gln Ile Glu Ala  Asn Lys Asp 
    2600                 2605                 2610             


Gln Ser  Gly Ala Glu Ser Thr  Ile Pro Asp Ala Asp  Gln Leu Lys 
    2615                 2620                 2625             


Glu Lys  Ile Lys Asp Leu Glu  Thr Gln Leu Lys Met  Ser Asp Leu 
    2630                 2635                 2640             


Glu Lys  Gln His Leu Lys Glu  Glu Ile Lys Lys Leu  Lys Lys Glu 
    2645                 2650                 2655             


Leu Glu  Asn Phe Asp Pro Ser  Phe Phe Glu Glu Ile  Glu Asp Leu 
    2660                 2665                 2670             


Lys Tyr  Asn Tyr Lys Glu Glu  Val Lys Lys Asn Ile  Leu Leu Glu 
    2675                 2680                 2685             


Glu Lys  Val Lys Lys Leu Ser  Glu Gln Leu Gly Val  Glu Leu Thr 
    2690                 2695                 2700             


Ser Pro  Val Ala Ala Ser Glu  Glu Phe Glu Asp Glu  Glu Glu Ser 
    2705                 2710                 2715             


Pro Val  Asn Phe Pro Ile Tyr  
    2720                 2725 


<210>  68
<211>  2714
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X6 
<Accession No.: XP_011537063.1>

<400>  68

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Gln Asn Gln  Ile Ser Gly Ile Glu  Ser Asp Asp 
    2330                 2335                 2340             


His Cys  Gln Arg Glu Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu 
    2345                 2350                 2355             


Ser Ser  Glu Asn Ile Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn 
    2360                 2365                 2370             


Lys Asp  Leu Pro Arg Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu 
    2375                 2380                 2385             


Met Cys  Glu Phe Leu Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys 
    2390                 2395                 2400             


Leu Gly  His Val Arg Gly Ala  Glu Leu Glu Lys Leu  Lys Ala His 
    2405                 2410                 2415             


Leu Gly  His Gln Leu Ser Met  His Tyr Glu Ser Lys  Thr Lys Gly 
    2420                 2425                 2430             


Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg Leu Arg  Lys Glu Leu 
    2435                 2440                 2445             


Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu Arg Ile  Ala Lys Asn 
    2450                 2455                 2460             


Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr Val Gln  Leu Glu Glu 
    2465                 2470                 2475             


Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser Arg Gly  Pro Gln Leu 
    2480                 2485                 2490             


Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser Ile Val  Val Thr Arg 
    2495                 2500                 2505             


Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu Thr Asp  Ile Ala Lys 
    2510                 2515                 2520             


Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln Leu Val  Lys Glu Ala 
    2525                 2530                 2535             


Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr Asn Glu  Asp Leu Glu 
    2540                 2545                 2550             


Gln Gln  Ile Lys Ile Leu Lys  His Val Pro Glu Gly  Ala Glu Thr 
    2555                 2560                 2565             


Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val Leu Arg  Leu Ala Asn 
    2570                 2575                 2580             


His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu Ile His  Gln Ile Glu 
    2585                 2590                 2595             


Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser Thr Ile  Pro Asp Ala 
    2600                 2605                 2610             


Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu Glu Thr  Gln Leu Lys 
    2615                 2620                 2625             


Met Ser  Asp Leu Glu Lys Gln  His Leu Lys Glu Glu  Ile Lys Lys 
    2630                 2635                 2640             


Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro Ser Phe  Phe Glu Glu 
    2645                 2650                 2655             


Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu Glu Val  Lys Lys Asn 
    2660                 2665                 2670             


Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu Ser Glu  Gln Leu Gly 
    2675                 2680                 2685             


Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser Glu Glu  Phe Glu Asp 
    2690                 2695                 2700             


Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile Tyr 
    2705                 2710                 


<210>  69
<211>  2711
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X7 <Accession 
No.: XM_017019981.2>

<400>  69

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Ile Ser Gly  Ile Glu Ser Asp Asp  His Cys Gln 
    2330                 2335                 2340             


Arg Glu  Gln Glu Leu Gln Lys  Glu Asn Leu Lys Leu  Ser Ser Glu 
    2345                 2350                 2355             


Asn Ile  Glu Leu Lys Phe Gln  Leu Glu Gln Ala Asn  Lys Asp Leu 
    2360                 2365                 2370             


Pro Arg  Leu Lys Asn Gln Val  Arg Asp Leu Lys Glu  Met Cys Glu 
    2375                 2380                 2385             


Phe Leu  Lys Lys Glu Lys Ala  Glu Val Gln Arg Lys  Leu Gly His 
    2390                 2395                 2400             


Val Arg  Gly Ala Glu Leu Glu  Lys Leu Lys Ala His  Leu Gly His 
    2405                 2410                 2415             


Gln Leu  Ser Met His Tyr Glu  Ser Lys Thr Lys Gly  Thr Glu Lys 
    2420                 2425                 2430             


Ile Ile  Ala Glu Asn Glu Arg  Leu Arg Lys Glu Leu  Lys Lys Glu 
    2435                 2440                 2445             


Thr Asp  Ala Ala Glu Lys Leu  Arg Ile Ala Lys Asn  Asn Leu Glu 
    2450                 2455                 2460             


Ile Leu  Asn Glu Lys Met Thr  Val Gln Leu Glu Glu  Thr Gly Lys 
    2465                 2470                 2475             


Arg Leu  Gln Phe Ala Glu Ser  Arg Gly Pro Gln Leu  Glu Gly Ala 
    2480                 2485                 2490             


Asp Ser  Lys Ser Trp Lys Ser  Ile Val Val Thr Arg  Met Tyr Glu 
    2495                 2500                 2505             


Thr Lys  Leu Lys Glu Leu Glu  Thr Asp Ile Ala Lys  Lys Asn Gln 
    2510                 2515                 2520             


Ser Ile  Thr Asp Leu Lys Gln  Leu Val Lys Glu Ala  Thr Glu Arg 
    2525                 2530                 2535             


Glu Gln  Lys Val Asn Lys Tyr  Asn Glu Asp Leu Glu  Gln Gln Ile 
    2540                 2545                 2550             


Lys Ile  Leu Lys His Val Pro  Glu Gly Ala Glu Thr  Glu Gln Gly 
    2555                 2560                 2565             


Leu Lys  Arg Glu Leu Gln Val  Leu Arg Leu Ala Asn  His Gln Leu 
    2570                 2575                 2580             


Asp Lys  Glu Lys Ala Glu Leu  Ile His Gln Ile Glu  Ala Asn Lys 
    2585                 2590                 2595             


Asp Gln  Ser Gly Ala Glu Ser  Thr Ile Pro Asp Ala  Asp Gln Leu 
    2600                 2605                 2610             


Lys Glu  Lys Ile Lys Asp Leu  Glu Thr Gln Leu Lys  Met Ser Asp 
    2615                 2620                 2625             


Leu Glu  Lys Gln His Leu Lys  Glu Glu Ile Lys Lys  Leu Lys Lys 
    2630                 2635                 2640             


Glu Leu  Glu Asn Phe Asp Pro  Ser Phe Phe Glu Glu  Ile Glu Asp 
    2645                 2650                 2655             


Leu Lys  Tyr Asn Tyr Lys Glu  Glu Val Lys Lys Asn  Ile Leu Leu 
    2660                 2665                 2670             


Glu Glu  Lys Val Lys Lys Leu  Ser Glu Gln Leu Gly  Val Glu Leu 
    2675                 2680                 2685             


Thr Ser  Pro Val Ala Ala Ser  Glu Glu Phe Glu Asp  Glu Glu Glu 
    2690                 2695                 2700             


Ser Pro  Val Asn Phe Pro Ile  Tyr 
    2705                 2710     


<210>  70
<211>  2612
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X8 <Accession 
No.: XP_016875471.1>

<400>  70

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Gln Asn Gln  Ile Ser Gly Ile Glu  Ser Asp Asp 
    2330                 2335                 2340             


His Cys  Gln Arg Glu Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu 
    2345                 2350                 2355             


Ser Ser  Glu Asn Ile Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn 
    2360                 2365                 2370             


Lys Asp  Leu Pro Arg Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu 
    2375                 2380                 2385             


Met Cys  Glu Phe Leu Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys 
    2390                 2395                 2400             


Leu Gly  His Val Arg Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro 
    2405                 2410                 2415             


Glu Leu  Glu Lys Thr Ile Gly  Leu Met Lys Lys Val  Val Glu Lys 
    2420                 2425                 2430             


Val Gln  Arg Glu Asn Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu 
    2435                 2440                 2445             


Thr Ser  Glu Lys Met Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu 
    2450                 2455                 2460             


Lys Ala  Glu Leu Glu Lys Leu  Lys Ala His Leu Gly  His Gln Leu 
    2465                 2470                 2475             


Ser Met  His Tyr Glu Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile 
    2480                 2485                 2490             


Ala Glu  Asn Glu Arg Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp 
    2495                 2500                 2505             


Ala Ala  Glu Lys Leu Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu 
    2510                 2515                 2520             


Asn Glu  Lys Met Thr Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu 
    2525                 2530                 2535             


Gln Phe  Ala Glu Ser Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser 
    2540                 2545                 2550             


Lys Ser  Trp Lys Ser Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys 
    2555                 2560                 2565             


Leu Lys  Glu Leu Glu Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile 
    2570                 2575                 2580             


Thr Asp  Leu Lys Gln Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln 
    2585                 2590                 2595             


Lys Val  Asn Lys Tyr Asn Glu  Asp Leu Glu Gln Gln  Ile Ser 
    2600                 2605                 2610         


<210>  71
<211>  2513
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X9 <Accession 
No.: XP_011537064.1>

<400>  71

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
    610                 615                 620                 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
625                 630                 635                 640 


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
                645                 650                 655     


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
            660                 665                 670         


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
        675                 680                 685             


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
    690                 695                 700                 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
705                 710                 715                 720 


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
                725                 730                 735     


Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg Glu 
            740                 745                 750         


Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala Asn 
        755                 760                 765             


Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln Ser 
    770                 775                 780                 


Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly Ile 
785                 790                 795                 800 


Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu Ile 
                805                 810                 815     


His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn Leu 
            820                 825                 830         


Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg His 
        835                 840                 845             


Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr Trp 
    850                 855                 860                 


Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu Asp 
865                 870                 875                 880 


Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu Leu 
                885                 890                 895     


Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala Glu 
            900                 905                 910         


Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu Ile 
        915                 920                 925             


Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys Glu 
    930                 935                 940                 


Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val Cys 
945                 950                 955                 960 


Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe Lys 
                965                 970                 975     


Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser Glu 
            980                 985                 990         


Leu Glu Leu Ala Asn Lys Gln Tyr  Asn Glu Leu Thr Ala  Lys Tyr Arg 
        995                 1000                 1005             


Asp Ile  Leu Gln Lys Asp Asn  Met Leu Val Gln Arg  Thr Ser Asn 
    1010                 1015                 1020             


Leu Glu  His Leu Glu Cys Glu  Asn Ile Ser Leu Lys  Glu Gln Val 
    1025                 1030                 1035             


Glu Ser  Ile Asn Lys Glu Leu  Glu Ile Thr Lys Glu  Lys Leu His 
    1040                 1045                 1050             


Thr Ile  Glu Gln Ala Trp Glu  Gln Glu Thr Lys Leu  Gly Asn Glu 
    1055                 1060                 1065             


Ser Ser  Met Asp Lys Ala Lys  Lys Ser Ile Thr Asn  Ser Asp Ile 
    1070                 1075                 1080             


Val Ser  Ile Ser Lys Lys Ile  Thr Met Leu Glu Met  Lys Glu Leu 
    1085                 1090                 1095             


Asn Glu  Arg Gln Arg Ala Glu  His Cys Gln Lys Met  Tyr Glu His 
    1100                 1105                 1110             


Leu Arg  Thr Ser Leu Lys Gln  Met Glu Glu Arg Asn  Phe Glu Leu 
    1115                 1120                 1125             


Glu Thr  Lys Phe Ala Glu Leu  Thr Lys Ile Asn Leu  Asp Ala Gln 
    1130                 1135                 1140             


Lys Val  Glu Gln Met Leu Arg  Asp Glu Leu Ala Asp  Ser Val Ser 
    1145                 1150                 1155             


Lys Ala  Val Ser Asp Ala Asp  Arg Gln Arg Ile Leu  Glu Leu Glu 
    1160                 1165                 1170             


Lys Asn  Glu Met Glu Leu Lys  Val Glu Val Ser Lys  Leu Arg Glu 
    1175                 1180                 1185             


Ile Ser  Asp Ile Ala Arg Arg  Gln Val Glu Ile Leu  Asn Ala Gln 
    1190                 1195                 1200             


Gln Gln  Ser Arg Asp Lys Glu  Val Glu Ser Leu Arg  Met Gln Leu 
    1205                 1210                 1215             


Leu Asp  Tyr Gln Ala Gln Ser  Asp Glu Lys Ser Leu  Ile Ala Lys 
    1220                 1225                 1230             


Leu His  Gln His Asn Val Ser  Leu Gln Leu Ser Glu  Ala Thr Ala 
    1235                 1240                 1245             


Leu Gly  Lys Leu Glu Ser Ile  Thr Ser Lys Leu Gln  Lys Met Glu 
    1250                 1255                 1260             


Ala Tyr  Asn Leu Arg Leu Glu  Gln Lys Leu Asp Glu  Lys Glu Gln 
    1265                 1270                 1275             


Ala Leu  Tyr Tyr Ala Arg Leu  Glu Gly Arg Asn Arg  Ala Lys His 
    1280                 1285                 1290             


Leu Arg  Gln Thr Ile Gln Ser  Leu Arg Arg Gln Phe  Ser Gly Ala 
    1295                 1300                 1305             


Leu Pro  Leu Ala Gln Gln Glu  Lys Phe Ser Lys Thr  Met Ile Gln 
    1310                 1315                 1320             


Leu Gln  Asn Asp Lys Leu Lys  Ile Met Gln Glu Met  Lys Asn Ser 
    1325                 1330                 1335             


Gln Gln  Glu His Arg Asn Met  Glu Asn Lys Thr Leu  Glu Met Glu 
    1340                 1345                 1350             


Leu Lys  Leu Lys Gly Leu Glu  Glu Leu Ile Ser Thr  Leu Lys Asp 
    1355                 1360                 1365             


Thr Lys  Gly Ala Gln Lys Val  Ile Asn Trp His Met  Lys Ile Glu 
    1370                 1375                 1380             


Glu Leu  Arg Leu Gln Glu Leu  Lys Leu Asn Arg Glu  Leu Val Lys 
    1385                 1390                 1395             


Asp Lys  Glu Glu Ile Lys Tyr  Leu Asn Asn Ile Ile  Ser Glu Tyr 
    1400                 1405                 1410             


Glu Arg  Thr Ile Ser Ser Leu  Glu Glu Glu Ile Val  Gln Gln Asn 
    1415                 1420                 1425             


Lys Phe  His Glu Glu Arg Gln  Met Ala Trp Asp Gln  Arg Glu Val 
    1430                 1435                 1440             


Asp Leu  Glu Arg Gln Leu Asp  Ile Phe Asp Arg Gln  Gln Asn Glu 
    1445                 1450                 1455             


Ile Leu  Asn Ala Ala Gln Lys  Phe Glu Glu Ala Thr  Gly Ser Ile 
    1460                 1465                 1470             


Pro Asp  Pro Ser Leu Pro Leu  Pro Asn Gln Leu Glu  Ile Ala Leu 
    1475                 1480                 1485             


Arg Lys  Ile Lys Glu Asn Ile  Arg Ile Ile Leu Glu  Thr Arg Ala 
    1490                 1495                 1500             


Thr Cys  Lys Ser Leu Glu Glu  Lys Leu Lys Glu Lys  Glu Ser Ala 
    1505                 1510                 1515             


Leu Arg  Leu Ala Glu Gln Asn  Ile Leu Ser Arg Asp  Lys Val Ile 
    1520                 1525                 1530             


Asn Glu  Leu Arg Leu Arg Leu  Pro Ala Thr Ala Glu  Arg Glu Lys 
    1535                 1540                 1545             


Leu Ile  Ala Glu Leu Gly Arg  Lys Glu Met Glu Pro  Lys Ser His 
    1550                 1555                 1560             


His Thr  Leu Lys Ile Ala His  Gln Thr Ile Ala Asn  Met Gln Ala 
    1565                 1570                 1575             


Arg Leu  Asn Gln Lys Glu Glu  Val Leu Lys Lys Tyr  Gln Arg Leu 
    1580                 1585                 1590             


Leu Glu  Lys Ala Arg Glu Glu  Gln Arg Glu Ile Val  Lys Lys His 
    1595                 1600                 1605             


Glu Glu  Asp Leu His Ile Leu  His His Arg Leu Glu  Leu Gln Ala 
    1610                 1615                 1620             


Asp Ser  Ser Leu Asn Lys Phe  Lys Gln Thr Ala Trp  Asp Leu Met 
    1625                 1630                 1635             


Lys Gln  Ser Pro Thr Pro Val  Pro Thr Asn Lys His  Phe Ile Arg 
    1640                 1645                 1650             


Leu Ala  Glu Met Glu Gln Thr  Val Ala Glu Gln Asp  Asp Ser Leu 
    1655                 1660                 1665             


Ser Ser  Leu Leu Val Lys Leu  Lys Lys Val Ser Gln  Asp Leu Glu 
    1670                 1675                 1680             


Arg Gln  Arg Glu Ile Thr Glu  Leu Lys Val Lys Glu  Phe Glu Asn 
    1685                 1690                 1695             


Ile Lys  Leu Gln Leu Gln Glu  Asn His Glu Asp Glu  Val Lys Lys 
    1700                 1705                 1710             


Val Lys  Ala Glu Val Glu Asp  Leu Lys Tyr Leu Leu  Asp Gln Ser 
    1715                 1720                 1725             


Gln Lys  Glu Ser Gln Cys Leu  Lys Ser Glu Leu Gln  Ala Gln Lys 
    1730                 1735                 1740             


Glu Ala  Asn Ser Arg Ala Pro  Thr Thr Thr Met Arg  Asn Leu Val 
    1745                 1750                 1755             


Glu Arg  Leu Lys Ser Gln Leu  Ala Leu Lys Glu Lys  Gln Gln Lys 
    1760                 1765                 1770             


Ala Leu  Ser Arg Ala Leu Leu  Glu Leu Arg Ala Glu  Met Thr Ala 
    1775                 1780                 1785             


Ala Ala  Glu Glu Arg Ile Ile  Ser Ala Thr Ser Gln  Lys Glu Ala 
    1790                 1795                 1800             


His Leu  Asn Val Gln Gln Ile  Val Asp Arg His Thr  Arg Glu Leu 
    1805                 1810                 1815             


Lys Thr  Gln Val Glu Asp Leu  Asn Glu Asn Leu Leu  Lys Leu Lys 
    1820                 1825                 1830             


Glu Ala  Leu Lys Thr Ser Lys  Asn Arg Glu Asn Ser  Leu Thr Asp 
    1835                 1840                 1845             


Asn Leu  Asn Asp Leu Asn Asn  Glu Leu Gln Lys Lys  Gln Lys Ala 
    1850                 1855                 1860             


Tyr Asn  Lys Ile Leu Arg Glu  Lys Glu Glu Ile Asp  Gln Glu Asn 
    1865                 1870                 1875             


Asp Glu  Leu Lys Arg Gln Ile  Lys Arg Leu Thr Ser  Gly Leu Gln 
    1880                 1885                 1890             


Gly Lys  Pro Leu Thr Asp Asn  Lys Gln Ser Leu Ile  Glu Glu Leu 
    1895                 1900                 1905             


Gln Arg  Lys Val Lys Lys Leu  Glu Asn Gln Leu Glu  Gly Lys Val 
    1910                 1915                 1920             


Glu Glu  Val Asp Leu Lys Pro  Met Lys Glu Lys Asn  Ala Lys Glu 
    1925                 1930                 1935             


Glu Leu  Ile Arg Trp Glu Glu  Gly Lys Lys Trp Gln  Ala Lys Ile 
    1940                 1945                 1950             


Glu Gly  Ile Arg Asn Lys Leu  Lys Glu Lys Glu Gly  Glu Val Phe 
    1955                 1960                 1965             


Thr Leu  Thr Lys Gln Leu Asn  Thr Leu Lys Asp Leu  Phe Ala Lys 
    1970                 1975                 1980             


Ala Asp  Lys Glu Lys Leu Thr  Leu Gln Arg Lys Leu  Lys Thr Thr 
    1985                 1990                 1995             


Gly Met  Thr Val Asp Gln Val  Leu Gly Ile Arg Ala  Leu Glu Ser 
    2000                 2005                 2010             


Glu Lys  Glu Leu Glu Glu Leu  Lys Lys Arg Asn Leu  Asp Leu Glu 
    2015                 2020                 2025             


Asn Asp  Ile Leu Tyr Met Arg  Ala His Gln Ala Leu  Pro Arg Asp 
    2030                 2035                 2040             


Ser Val  Val Glu Asp Leu His  Leu Gln Asn Arg Tyr  Leu Gln Glu 
    2045                 2050                 2055             


Lys Leu  His Ala Leu Glu Lys  Gln Phe Ser Lys Asp  Thr Tyr Ser 
    2060                 2065                 2070             


Lys Pro  Ser Gln Asn Gln Ile  Ser Gly Ile Glu Ser  Asp Asp His 
    2075                 2080                 2085             


Cys Gln  Arg Glu Gln Glu Leu  Gln Lys Glu Asn Leu  Lys Leu Ser 
    2090                 2095                 2100             


Ser Glu  Asn Ile Glu Leu Lys  Phe Gln Leu Glu Gln  Ala Asn Lys 
    2105                 2110                 2115             


Asp Leu  Pro Arg Leu Lys Asn  Gln Val Arg Asp Leu  Lys Glu Met 
    2120                 2125                 2130             


Cys Glu  Phe Leu Lys Lys Glu  Lys Ala Glu Val Gln  Arg Lys Leu 
    2135                 2140                 2145             


Gly His  Val Arg Gly Ser Gly  Arg Ser Gly Lys Thr  Ile Pro Glu 
    2150                 2155                 2160             


Leu Glu  Lys Thr Ile Gly Leu  Met Lys Lys Val Val  Glu Lys Val 
    2165                 2170                 2175             


Gln Arg  Glu Asn Glu Gln Leu  Lys Lys Ala Ser Gly  Ile Leu Thr 
    2180                 2185                 2190             


Ser Glu  Lys Met Ala Asn Ile  Glu Gln Glu Asn Glu  Lys Leu Lys 
    2195                 2200                 2205             


Ala Glu  Leu Glu Lys Leu Lys  Ala His Leu Gly His  Gln Leu Ser 
    2210                 2215                 2220             


Met His  Tyr Glu Ser Lys Thr  Lys Gly Thr Glu Lys  Ile Ile Ala 
    2225                 2230                 2235             


Glu Asn  Glu Arg Leu Arg Lys  Glu Leu Lys Lys Glu  Thr Asp Ala 
    2240                 2245                 2250             


Ala Glu  Lys Leu Arg Ile Ala  Lys Asn Asn Leu Glu  Ile Leu Asn 
    2255                 2260                 2265             


Glu Lys  Met Thr Val Gln Leu  Glu Glu Thr Gly Lys  Arg Leu Gln 
    2270                 2275                 2280             


Phe Ala  Glu Ser Arg Gly Pro  Gln Leu Glu Gly Ala  Asp Ser Lys 
    2285                 2290                 2295             


Ser Trp  Lys Ser Ile Val Val  Thr Arg Met Tyr Glu  Thr Lys Leu 
    2300                 2305                 2310             


Lys Glu  Leu Glu Thr Asp Ile  Ala Lys Lys Asn Gln  Ser Ile Thr 
    2315                 2320                 2325             


Asp Leu  Lys Gln Leu Val Lys  Glu Ala Thr Glu Arg  Glu Gln Lys 
    2330                 2335                 2340             


Val Asn  Lys Tyr Asn Glu Asp  Leu Glu Gln Gln Ile  Lys Ile Leu 
    2345                 2350                 2355             


Lys His  Val Pro Glu Gly Ala  Glu Thr Glu Gln Gly  Leu Lys Arg 
    2360                 2365                 2370             


Glu Leu  Gln Val Leu Arg Leu  Ala Asn His Gln Leu  Asp Lys Glu 
    2375                 2380                 2385             


Lys Ala  Glu Leu Ile His Gln  Ile Glu Ala Asn Lys  Asp Gln Ser 
    2390                 2395                 2400             


Gly Ala  Glu Ser Thr Ile Pro  Asp Ala Asp Gln Leu  Lys Glu Lys 
    2405                 2410                 2415             


Ile Lys  Asp Leu Glu Thr Gln  Leu Lys Met Ser Asp  Leu Glu Lys 
    2420                 2425                 2430             


Gln His  Leu Lys Glu Glu Ile  Lys Lys Leu Lys Lys  Glu Leu Glu 
    2435                 2440                 2445             


Asn Phe  Asp Pro Ser Phe Phe  Glu Glu Ile Glu Asp  Leu Lys Tyr 
    2450                 2455                 2460             


Asn Tyr  Lys Glu Glu Val Lys  Lys Asn Ile Leu Leu  Glu Glu Lys 
    2465                 2470                 2475             


Val Lys  Lys Leu Ser Glu Gln  Leu Gly Val Glu Leu  Thr Ser Pro 
    2480                 2485                 2490             


Val Ala  Ala Ser Glu Glu Phe  Glu Asp Glu Glu Glu  Ser Pro Val 
    2495                 2500                 2505             


Asn Phe  Pro Ile Tyr 
    2510             


<210>  72
<211>  2482
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X10 <Accession 
No.: XP_011537065.1>

<400>  72

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Gln Asn Gln Ile Ser  Gly Ile Glu Ser Asp  Asp His Cys 
    2045                 2050                 2055             


Gln Arg  Glu Gln Glu Leu Gln  Lys Glu Asn Leu Lys  Leu Ser Ser 
    2060                 2065                 2070             


Glu Asn  Ile Glu Leu Lys Phe  Gln Leu Glu Gln Ala  Asn Lys Asp 
    2075                 2080                 2085             


Leu Pro  Arg Leu Lys Asn Gln  Val Arg Asp Leu Lys  Glu Met Cys 
    2090                 2095                 2100             


Glu Phe  Leu Lys Lys Glu Lys  Ala Glu Val Gln Arg  Lys Leu Gly 
    2105                 2110                 2115             


His Val  Arg Gly Ser Gly Arg  Ser Gly Lys Thr Ile  Pro Glu Leu 
    2120                 2125                 2130             


Glu Lys  Thr Ile Gly Leu Met  Lys Lys Val Val Glu  Lys Val Gln 
    2135                 2140                 2145             


Arg Glu  Asn Glu Gln Leu Lys  Lys Ala Ser Gly Ile  Leu Thr Ser 
    2150                 2155                 2160             


Glu Lys  Met Ala Asn Ile Glu  Gln Glu Asn Glu Lys  Leu Lys Ala 
    2165                 2170                 2175             


Glu Leu  Glu Lys Leu Lys Ala  His Leu Gly His Gln  Leu Ser Met 
    2180                 2185                 2190             


His Tyr  Glu Ser Lys Thr Lys  Gly Thr Glu Lys Ile  Ile Ala Glu 
    2195                 2200                 2205             


Asn Glu  Arg Leu Arg Lys Glu  Leu Lys Lys Glu Thr  Asp Ala Ala 
    2210                 2215                 2220             


Glu Lys  Leu Arg Ile Ala Lys  Asn Asn Leu Glu Ile  Leu Asn Glu 
    2225                 2230                 2235             


Lys Met  Thr Val Gln Leu Glu  Glu Thr Gly Lys Arg  Leu Gln Phe 
    2240                 2245                 2250             


Ala Glu  Ser Arg Gly Pro Gln  Leu Glu Gly Ala Asp  Ser Lys Ser 
    2255                 2260                 2265             


Trp Lys  Ser Ile Val Val Thr  Arg Met Tyr Glu Thr  Lys Leu Lys 
    2270                 2275                 2280             


Glu Leu  Glu Thr Asp Ile Ala  Lys Lys Asn Gln Ser  Ile Thr Asp 
    2285                 2290                 2295             


Leu Lys  Gln Leu Val Lys Glu  Ala Thr Glu Arg Glu  Gln Lys Val 
    2300                 2305                 2310             


Asn Lys  Tyr Asn Glu Asp Leu  Glu Gln Gln Ile Lys  Ile Leu Lys 
    2315                 2320                 2325             


His Val  Pro Glu Gly Ala Glu  Thr Glu Gln Gly Leu  Lys Arg Glu 
    2330                 2335                 2340             


Leu Gln  Val Leu Arg Leu Ala  Asn His Gln Leu Asp  Lys Glu Lys 
    2345                 2350                 2355             


Ala Glu  Leu Ile His Gln Ile  Glu Ala Asn Lys Asp  Gln Ser Gly 
    2360                 2365                 2370             


Ala Glu  Ser Thr Ile Pro Asp  Ala Asp Gln Leu Lys  Glu Lys Ile 
    2375                 2380                 2385             


Lys Asp  Leu Glu Thr Gln Leu  Lys Met Ser Asp Leu  Glu Lys Gln 
    2390                 2395                 2400             


His Leu  Lys Glu Glu Ile Lys  Lys Leu Lys Lys Glu  Leu Glu Asn 
    2405                 2410                 2415             


Phe Asp  Pro Ser Phe Phe Glu  Glu Ile Glu Asp Leu  Lys Tyr Asn 
    2420                 2425                 2430             


Tyr Lys  Glu Glu Val Lys Lys  Asn Ile Leu Leu Glu  Glu Lys Val 
    2435                 2440                 2445             


Lys Lys  Leu Ser Glu Gln Leu  Gly Val Glu Leu Thr  Ser Pro Val 
    2450                 2455                 2460             


Ala Ala  Ser Glu Glu Phe Glu  Asp Glu Glu Glu Ser  Pro Val Asn 
    2465                 2470                 2475             


Phe Pro  Ile Tyr 
    2480         


<210>  73
<211>  2475
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X11 <Accession 
No.: XP_016875472.1>

<400>  73

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Glu Gln Leu Cys Gln Asp Ile Ile Asp Tyr 
                165                 170                 175     


Gln Lys Gln Ile Asp Ser Gln Lys Glu Thr Leu Leu Ser Arg Arg Gly 
            180                 185                 190         


Glu Asp Ser Asp Tyr Arg Ser Gln Leu Ser Lys Lys Asn Tyr Glu Leu 
        195                 200                 205             


Ile Gln Tyr Leu Asp Glu Ile Gln Thr Leu Thr Glu Ala Asn Glu Lys 
    210                 215                 220                 


Ile Glu Val Gln Asn Gln Glu Met Arg Lys Asn Leu Glu Glu Ser Val 
225                 230                 235                 240 


Gln Glu Met Glu Lys Met Thr Asp Glu Tyr Asn Arg Met Lys Ala Ile 
                245                 250                 255     


Val His Gln Thr Asp Asn Val Ile Asp Gln Leu Lys Lys Glu Asn Asp 
            260                 265                 270         


His Tyr Gln Leu Gln Val Gln Glu Leu Thr Asp Leu Leu Lys Ser Lys 
        275                 280                 285             


Asn Glu Glu Asp Asp Pro Ile Met Val Ala Val Asn Ala Lys Val Glu 
    290                 295                 300                 


Glu Trp Lys Leu Ile Leu Ser Ser Lys Asp Asp Glu Ile Ile Glu Tyr 
305                 310                 315                 320 


Gln Gln Met Leu His Asn Leu Arg Glu Lys Leu Lys Asn Ala Gln Leu 
                325                 330                 335     


Asp Ala Asp Lys Ser Asn Val Met Ala Leu Gln Gln Gly Ile Gln Glu 
            340                 345                 350         


Arg Asp Ser Gln Ile Lys Met Leu Thr Glu Gln Val Glu Gln Tyr Thr 
        355                 360                 365             


Lys Glu Met Glu Lys Asn Thr Cys Ile Ile Glu Asp Leu Lys Asn Glu 
    370                 375                 380                 


Leu Gln Arg Asn Lys Gly Ala Ser Thr Leu Ser Gln Gln Thr His Met 
385                 390                 395                 400 


Lys Ile Gln Ser Thr Leu Asp Ile Leu Lys Glu Lys Thr Lys Glu Ala 
                405                 410                 415     


Glu Arg Thr Ala Glu Leu Ala Glu Ala Asp Ala Arg Glu Lys Asp Lys 
            420                 425                 430         


Glu Leu Val Glu Ala Leu Lys Arg Leu Lys Asp Tyr Glu Ser Gly Val 
        435                 440                 445             


Tyr Gly Leu Glu Asp Ala Val Val Glu Ile Lys Asn Cys Lys Asn Gln 
    450                 455                 460                 


Ile Lys Ile Arg Asp Arg Glu Ile Glu Ile Leu Thr Lys Glu Ile Asn 
465                 470                 475                 480 


Lys Leu Glu Leu Lys Ile Ser Asp Phe Leu Asp Glu Asn Glu Ala Leu 
                485                 490                 495     


Arg Glu Arg Val Gly Leu Glu Pro Lys Thr Met Ile Asp Leu Thr Glu 
            500                 505                 510         


Phe Arg Asn Ser Lys His Leu Lys Gln Gln Gln Tyr Arg Ala Glu Asn 
        515                 520                 525             


Gln Ile Leu Leu Lys Glu Ile Glu Ser Leu Glu Glu Glu Arg Leu Asp 
    530                 535                 540                 


Leu Lys Lys Lys Ile Arg Gln Met Ala Gln Glu Arg Gly Lys Arg Ser 
545                 550                 555                 560 


Ala Thr Ser Gly Leu Thr Thr Glu Asp Leu Asn Leu Thr Glu Asn Ile 
                565                 570                 575     


Ser Gln Gly Asp Arg Ile Ser Glu Arg Lys Leu Asp Leu Leu Ser Leu 
            580                 585                 590         


Lys Asn Met Ser Glu Ala Gln Ser Lys Asn Glu Phe Leu Ser Arg Glu 
        595                 600                 605             


Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg Ser Arg Thr Val Ile Ala 
    610                 615                 620                 


Lys Phe Gln Asn Lys Leu Lys Glu Leu Val Glu Glu Asn Lys Gln Leu 
625                 630                 635                 640 


Glu Glu Gly Met Lys Glu Ile Leu Gln Ala Ile Lys Glu Met Gln Lys 
                645                 650                 655     


Asp Pro Asp Val Lys Gly Gly Glu Thr Ser Leu Ile Ile Pro Ser Leu 
            660                 665                 670         


Glu Arg Leu Val Asn Ala Ile Glu Ser Lys Asn Ala Glu Gly Ile Phe 
        675                 680                 685             


Asp Ala Ser Leu His Leu Lys Ala Gln Val Asp Gln Leu Thr Gly Arg 
    690                 695                 700                 


Asn Glu Glu Leu Arg Gln Glu Leu Arg Glu Ser Arg Lys Glu Ala Ile 
705                 710                 715                 720 


Asn Tyr Ser Gln Gln Leu Ala Lys Ala Asn Leu Lys Ile Asp His Leu 
                725                 730                 735     


Glu Lys Glu Thr Ser Leu Leu Arg Gln Ser Glu Gly Ser Asn Val Val 
            740                 745                 750         


Phe Lys Gly Ile Asp Leu Pro Asp Gly Ile Ala Pro Ser Ser Ala Ser 
        755                 760                 765             


Ile Ile Asn Ser Gln Asn Glu Tyr Leu Ile His Leu Leu Gln Glu Leu 
    770                 775                 780                 


Glu Asn Lys Glu Lys Lys Leu Lys Asn Leu Glu Asp Ser Leu Glu Asp 
785                 790                 795                 800 


Tyr Asn Arg Lys Phe Ala Val Ile Arg His Gln Gln Ser Leu Leu Tyr 
                805                 810                 815     


Lys Glu Tyr Leu Ser Glu Lys Glu Thr Trp Lys Thr Glu Ser Lys Thr 
            820                 825                 830         


Ile Lys Glu Glu Lys Arg Lys Leu Glu Asp Gln Val Gln Gln Asp Ala 
        835                 840                 845             


Ile Lys Val Lys Glu Tyr Asn Asn Leu Leu Asn Ala Leu Gln Met Asp 
    850                 855                 860                 


Ser Asp Glu Met Lys Lys Ile Leu Ala Glu Asn Ser Arg Lys Ile Thr 
865                 870                 875                 880 


Val Leu Gln Val Asn Glu Lys Ser Leu Ile Arg Gln Tyr Thr Thr Leu 
                885                 890                 895     


Val Glu Leu Glu Arg Gln Leu Arg Lys Glu Asn Glu Lys Gln Lys Asn 
            900                 905                 910         


Glu Leu Leu Ser Met Glu Ala Glu Val Cys Glu Lys Ile Gly Cys Leu 
        915                 920                 925             


Gln Arg Phe Lys Glu Met Ala Ile Phe Lys Ile Ala Ala Leu Gln Lys 
    930                 935                 940                 


Val Val Asp Asn Ser Val Ser Leu Ser Glu Leu Glu Leu Ala Asn Lys 
945                 950                 955                 960 


Gln Tyr Asn Glu Leu Thr Ala Lys Tyr Arg Asp Ile Leu Gln Lys Asp 
                965                 970                 975     


Asn Met Leu Val Gln Arg Thr Ser Asn Leu Glu His Leu Glu Cys Glu 
            980                 985                 990         


Asn Ile Ser Leu Lys Glu Gln Val  Glu Ser Ile Asn Lys  Glu Leu Glu 
        995                 1000                 1005             


Ile Thr  Lys Glu Lys Leu His  Thr Ile Glu Gln Ala  Trp Glu Gln 
    1010                 1015                 1020             


Glu Thr  Lys Leu Gly Asn Glu  Ser Ser Met Asp Lys  Ala Lys Lys 
    1025                 1030                 1035             


Ser Ile  Thr Asn Ser Asp Ile  Val Ser Ile Ser Lys  Lys Ile Thr 
    1040                 1045                 1050             


Met Leu  Glu Met Lys Glu Leu  Asn Glu Arg Gln Arg  Ala Glu His 
    1055                 1060                 1065             


Cys Gln  Lys Met Tyr Glu His  Leu Arg Thr Ser Leu  Lys Gln Met 
    1070                 1075                 1080             


Glu Glu  Arg Asn Phe Glu Leu  Glu Thr Lys Phe Ala  Glu Leu Thr 
    1085                 1090                 1095             


Lys Ile  Asn Leu Asp Ala Gln  Lys Val Glu Gln Met  Leu Arg Asp 
    1100                 1105                 1110             


Glu Leu  Ala Asp Ser Val Ser  Lys Ala Val Ser Asp  Ala Asp Arg 
    1115                 1120                 1125             


Gln Arg  Ile Leu Glu Leu Glu  Lys Asn Glu Met Glu  Leu Lys Val 
    1130                 1135                 1140             


Glu Val  Ser Lys Leu Arg Glu  Ile Ser Asp Ile Ala  Arg Arg Gln 
    1145                 1150                 1155             


Val Glu  Ile Leu Asn Ala Gln  Gln Gln Ser Arg Asp  Lys Glu Val 
    1160                 1165                 1170             


Glu Ser  Leu Arg Met Gln Leu  Leu Asp Tyr Gln Ala  Gln Ser Asp 
    1175                 1180                 1185             


Glu Lys  Ser Leu Ile Ala Lys  Leu His Gln His Asn  Val Ser Leu 
    1190                 1195                 1200             


Gln Leu  Ser Glu Ala Thr Ala  Leu Gly Lys Leu Glu  Ser Ile Thr 
    1205                 1210                 1215             


Ser Lys  Leu Gln Lys Met Glu  Ala Tyr Asn Leu Arg  Leu Glu Gln 
    1220                 1225                 1230             


Lys Leu  Asp Glu Lys Glu Gln  Ala Leu Tyr Tyr Ala  Arg Leu Glu 
    1235                 1240                 1245             


Gly Arg  Asn Arg Ala Lys His  Leu Arg Gln Thr Ile  Gln Ser Leu 
    1250                 1255                 1260             


Arg Arg  Gln Phe Ser Gly Ala  Leu Pro Leu Ala Gln  Gln Glu Lys 
    1265                 1270                 1275             


Phe Ser  Lys Thr Met Ile Gln  Leu Gln Asn Asp Lys  Leu Lys Ile 
    1280                 1285                 1290             


Met Gln  Glu Met Lys Asn Ser  Gln Gln Glu His Arg  Asn Met Glu 
    1295                 1300                 1305             


Asn Lys  Thr Leu Glu Met Glu  Leu Lys Leu Lys Gly  Leu Glu Glu 
    1310                 1315                 1320             


Leu Ile  Ser Thr Leu Lys Asp  Thr Lys Gly Ala Gln  Lys Val Ile 
    1325                 1330                 1335             


Asn Trp  His Met Lys Ile Glu  Glu Leu Arg Leu Gln  Glu Leu Lys 
    1340                 1345                 1350             


Leu Asn  Arg Glu Leu Val Lys  Asp Lys Glu Glu Ile  Lys Tyr Leu 
    1355                 1360                 1365             


Asn Asn  Ile Ile Ser Glu Tyr  Glu Arg Thr Ile Ser  Ser Leu Glu 
    1370                 1375                 1380             


Glu Glu  Ile Val Gln Gln Asn  Lys Phe His Glu Glu  Arg Gln Met 
    1385                 1390                 1395             


Ala Trp  Asp Gln Arg Glu Val  Asp Leu Glu Arg Gln  Leu Asp Ile 
    1400                 1405                 1410             


Phe Asp  Arg Gln Gln Asn Glu  Ile Leu Asn Ala Ala  Gln Lys Phe 
    1415                 1420                 1425             


Glu Glu  Ala Thr Gly Ser Ile  Pro Asp Pro Ser Leu  Pro Leu Pro 
    1430                 1435                 1440             


Asn Gln  Leu Glu Ile Ala Leu  Arg Lys Ile Lys Glu  Asn Ile Arg 
    1445                 1450                 1455             


Ile Ile  Leu Glu Thr Arg Ala  Thr Cys Lys Ser Leu  Glu Glu Lys 
    1460                 1465                 1470             


Leu Lys  Glu Lys Glu Ser Ala  Leu Arg Leu Ala Glu  Gln Asn Ile 
    1475                 1480                 1485             


Leu Ser  Arg Asp Lys Val Ile  Asn Glu Leu Arg Leu  Arg Leu Pro 
    1490                 1495                 1500             


Ala Thr  Ala Glu Arg Glu Lys  Leu Ile Ala Glu Leu  Gly Arg Lys 
    1505                 1510                 1515             


Glu Met  Glu Pro Lys Ser His  His Thr Leu Lys Ile  Ala His Gln 
    1520                 1525                 1530             


Thr Ile  Ala Asn Met Gln Ala  Arg Leu Asn Gln Lys  Glu Glu Val 
    1535                 1540                 1545             


Leu Lys  Lys Tyr Gln Arg Leu  Leu Glu Lys Ala Arg  Glu Glu Gln 
    1550                 1555                 1560             


Arg Glu  Ile Val Lys Lys His  Glu Glu Asp Leu His  Ile Leu His 
    1565                 1570                 1575             


His Arg  Leu Glu Leu Gln Ala  Asp Ser Ser Leu Asn  Lys Phe Lys 
    1580                 1585                 1590             


Gln Thr  Ala Trp Asp Leu Met  Lys Gln Ser Pro Thr  Pro Val Pro 
    1595                 1600                 1605             


Thr Asn  Lys His Phe Ile Arg  Leu Ala Glu Met Glu  Gln Thr Val 
    1610                 1615                 1620             


Ala Glu  Gln Asp Asp Ser Leu  Ser Ser Leu Leu Val  Lys Leu Lys 
    1625                 1630                 1635             


Lys Val  Ser Gln Asp Leu Glu  Arg Gln Arg Glu Ile  Thr Glu Leu 
    1640                 1645                 1650             


Lys Val  Lys Glu Phe Glu Asn  Ile Lys Leu Gln Leu  Gln Glu Asn 
    1655                 1660                 1665             


His Glu  Asp Glu Val Lys Lys  Val Lys Ala Glu Val  Glu Asp Leu 
    1670                 1675                 1680             


Lys Tyr  Leu Leu Asp Gln Ser  Gln Lys Glu Ser Gln  Cys Leu Lys 
    1685                 1690                 1695             


Ser Glu  Leu Gln Ala Gln Lys  Glu Ala Asn Ser Arg  Ala Pro Thr 
    1700                 1705                 1710             


Thr Thr  Met Arg Asn Leu Val  Glu Arg Leu Lys Ser  Gln Leu Ala 
    1715                 1720                 1725             


Leu Lys  Glu Lys Gln Gln Lys  Ala Leu Ser Arg Ala  Leu Leu Glu 
    1730                 1735                 1740             


Leu Arg  Ala Glu Met Thr Ala  Ala Ala Glu Glu Arg  Ile Ile Ser 
    1745                 1750                 1755             


Ala Thr  Ser Gln Lys Glu Ala  His Leu Asn Val Gln  Gln Ile Val 
    1760                 1765                 1770             


Asp Arg  His Thr Arg Glu Leu  Lys Thr Gln Val Glu  Asp Leu Asn 
    1775                 1780                 1785             


Glu Asn  Leu Leu Lys Leu Lys  Glu Ala Leu Lys Thr  Ser Lys Asn 
    1790                 1795                 1800             


Arg Glu  Asn Ser Leu Thr Asp  Asn Leu Asn Asp Leu  Asn Asn Glu 
    1805                 1810                 1815             


Leu Gln  Lys Lys Gln Lys Ala  Tyr Asn Lys Ile Leu  Arg Glu Lys 
    1820                 1825                 1830             


Glu Glu  Ile Asp Gln Glu Asn  Asp Glu Leu Lys Arg  Gln Ile Lys 
    1835                 1840                 1845             


Arg Leu  Thr Ser Gly Leu Gln  Gly Lys Pro Leu Thr  Asp Asn Lys 
    1850                 1855                 1860             


Gln Ser  Leu Ile Glu Glu Leu  Gln Arg Lys Val Lys  Lys Leu Glu 
    1865                 1870                 1875             


Asn Gln  Leu Glu Gly Lys Val  Glu Glu Val Asp Leu  Lys Pro Met 
    1880                 1885                 1890             


Lys Glu  Lys Asn Ala Lys Glu  Glu Leu Ile Arg Trp  Glu Glu Gly 
    1895                 1900                 1905             


Lys Lys  Trp Gln Ala Lys Ile  Glu Gly Ile Arg Asn  Lys Leu Lys 
    1910                 1915                 1920             


Glu Lys  Glu Gly Glu Val Phe  Thr Leu Thr Lys Gln  Leu Asn Thr 
    1925                 1930                 1935             


Leu Lys  Asp Leu Phe Ala Lys  Ala Asp Lys Glu Lys  Leu Thr Leu 
    1940                 1945                 1950             


Gln Arg  Lys Leu Lys Thr Thr  Gly Met Thr Val Asp  Gln Val Leu 
    1955                 1960                 1965             


Gly Ile  Arg Ala Leu Glu Ser  Glu Lys Glu Leu Glu  Glu Leu Lys 
    1970                 1975                 1980             


Lys Arg  Asn Leu Asp Leu Glu  Asn Asp Ile Leu Tyr  Met Arg Ala 
    1985                 1990                 1995             


His Gln  Ala Leu Pro Arg Asp  Ser Val Val Glu Asp  Leu His Leu 
    2000                 2005                 2010             


Gln Asn  Arg Tyr Leu Gln Glu  Lys Leu His Ala Leu  Glu Lys Gln 
    2015                 2020                 2025             


Phe Ser  Lys Asp Thr Tyr Ser  Lys Pro Ser Gln Asn  Gln Ile Ser 
    2030                 2035                 2040             


Gly Ile  Glu Ser Asp Asp His  Cys Gln Arg Glu Gln  Glu Leu Gln 
    2045                 2050                 2055             


Lys Glu  Asn Leu Lys Leu Ser  Ser Glu Asn Ile Glu  Leu Lys Phe 
    2060                 2065                 2070             


Gln Leu  Glu Gln Ala Asn Lys  Asp Leu Pro Arg Leu  Lys Asn Gln 
    2075                 2080                 2085             


Val Arg  Asp Leu Lys Glu Met  Cys Glu Phe Leu Lys  Lys Glu Lys 
    2090                 2095                 2100             


Ala Glu  Val Gln Arg Lys Leu  Gly His Val Arg Gly  Ser Gly Arg 
    2105                 2110                 2115             


Ser Gly  Lys Thr Ile Pro Glu  Leu Glu Lys Thr Ile  Gly Leu Met 
    2120                 2125                 2130             


Lys Lys  Val Val Glu Lys Val  Gln Arg Glu Asn Glu  Gln Leu Lys 
    2135                 2140                 2145             


Lys Ala  Ser Gly Ile Leu Thr  Ser Glu Lys Met Ala  Asn Ile Glu 
    2150                 2155                 2160             


Gln Glu  Asn Glu Lys Leu Lys  Ala Glu Leu Glu Lys  Leu Lys Ala 
    2165                 2170                 2175             


His Leu  Gly His Gln Leu Ser  Met His Tyr Glu Ser  Lys Thr Lys 
    2180                 2185                 2190             


Gly Thr  Glu Lys Ile Ile Ala  Glu Asn Glu Arg Leu  Arg Lys Glu 
    2195                 2200                 2205             


Leu Lys  Lys Glu Thr Asp Ala  Ala Glu Lys Leu Arg  Ile Ala Lys 
    2210                 2215                 2220             


Asn Asn  Leu Glu Ile Leu Asn  Glu Lys Met Thr Val  Gln Leu Glu 
    2225                 2230                 2235             


Glu Thr  Gly Lys Arg Leu Gln  Phe Ala Glu Ser Arg  Gly Pro Gln 
    2240                 2245                 2250             


Leu Glu  Gly Ala Asp Ser Lys  Ser Trp Lys Ser Ile  Val Val Thr 
    2255                 2260                 2265             


Arg Met  Tyr Glu Thr Lys Leu  Lys Glu Leu Glu Thr  Asp Ile Ala 
    2270                 2275                 2280             


Lys Lys  Asn Gln Ser Ile Thr  Asp Leu Lys Gln Leu  Val Lys Glu 
    2285                 2290                 2295             


Ala Thr  Glu Arg Glu Gln Lys  Val Asn Lys Tyr Asn  Glu Asp Leu 
    2300                 2305                 2310             


Glu Gln  Gln Ile Lys Ile Leu  Lys His Val Pro Glu  Gly Ala Glu 
    2315                 2320                 2325             


Thr Glu  Gln Gly Leu Lys Arg  Glu Leu Gln Val Leu  Arg Leu Ala 
    2330                 2335                 2340             


Asn His  Gln Leu Asp Lys Glu  Lys Ala Glu Leu Ile  His Gln Ile 
    2345                 2350                 2355             


Glu Ala  Asn Lys Asp Gln Ser  Gly Ala Glu Ser Thr  Ile Pro Asp 
    2360                 2365                 2370             


Ala Asp  Gln Leu Lys Glu Lys  Ile Lys Asp Leu Glu  Thr Gln Leu 
    2375                 2380                 2385             


Lys Met  Ser Asp Leu Glu Lys  Gln His Leu Lys Glu  Glu Ile Lys 
    2390                 2395                 2400             


Lys Leu  Lys Lys Glu Leu Glu  Asn Phe Asp Pro Ser  Phe Phe Glu 
    2405                 2410                 2415             


Glu Ile  Glu Asp Leu Lys Tyr  Asn Tyr Lys Glu Glu  Val Lys Lys 
    2420                 2425                 2430             


Asn Ile  Leu Leu Glu Glu Lys  Val Lys Lys Leu Ser  Glu Gln Leu 
    2435                 2440                 2445             


Gly Val  Glu Leu Thr Ser Pro  Val Ala Ala Ser Glu  Glu Phe Glu 
    2450                 2455                 2460             


Asp Glu  Glu Glu Ser Pro Val  Asn Phe Pro Ile Tyr  
    2465                 2470                 2475 


<210>  74
<211>  2366
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X12 <Accession 
No.: XP_011537066.1>

<400>  74

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Gln Asn Gln  Asp Thr Ser His Ser  Arg Ile Gly 
    2330                 2335                 2340             


Phe Thr  Leu Lys Ser His Phe  Asn Leu Asn Thr Ser  Val Lys Thr 
    2345                 2350                 2355             


Gln Ser  Pro Asn Lys Val Thr  Phe 
    2360                 2365     


<210>  75
<211>  2365
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X13 <Accession 
No.: XP_011537067.1>

<400>  75

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Ile Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile 
625                 630                 635                 640 


Gly Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser 
                645                 650                 655     


Gly Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln 
            660                 665                 670         


Val Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe 
        675                 680                 685             


Lys Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser 
    690                 695                 700                 


Thr Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe 
705                 710                 715                 720 


Ser Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu 
                725                 730                 735     


Lys Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser 
            740                 745                 750         


Thr Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala 
        755                 760                 765             


Ile Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser 
    770                 775                 780                 


Gln Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr 
785                 790                 795                 800 


Ala Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu 
                805                 810                 815     


Gln Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro 
            820                 825                 830         


Val Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu 
        835                 840                 845             


Asn Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln 
    850                 855                 860                 


Asn Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg 
865                 870                 875                 880 


Asn Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn 
                885                 890                 895     


Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg 
            900                 905                 910         


Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val 
        915                 920                 925             


Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala 
    930                 935                 940                 


Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser 
945                 950                 955                 960 


Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys 
                965                 970                 975     


Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val 
            980                 985                 990         


Asp Gln Leu Thr Gly Arg Asn Glu  Glu Leu Arg Gln Glu  Leu Arg Glu 
        995                 1000                 1005             


Ser Arg  Lys Glu Ala Ile Asn  Tyr Ser Gln Gln Leu  Ala Lys Ala 
    1010                 1015                 1020             


Asn Leu  Lys Ile Asp His Leu  Glu Lys Glu Thr Ser  Leu Leu Arg 
    1025                 1030                 1035             


Gln Ser  Glu Gly Ser Asn Val  Val Phe Lys Gly Ile  Asp Leu Pro 
    1040                 1045                 1050             


Asp Gly  Ile Ala Pro Ser Ser  Ala Ser Ile Ile Asn  Ser Gln Asn 
    1055                 1060                 1065             


Glu Tyr  Leu Ile His Leu Leu  Gln Glu Leu Glu Asn  Lys Glu Lys 
    1070                 1075                 1080             


Lys Leu  Lys Asn Leu Glu Asp  Ser Leu Glu Asp Tyr  Asn Arg Lys 
    1085                 1090                 1095             


Phe Ala  Val Ile Arg His Gln  Gln Ser Leu Leu Tyr  Lys Glu Tyr 
    1100                 1105                 1110             


Leu Ser  Glu Lys Glu Thr Trp  Lys Thr Glu Ser Lys  Thr Ile Lys 
    1115                 1120                 1125             


Glu Glu  Lys Arg Lys Leu Glu  Asp Gln Val Gln Gln  Asp Ala Ile 
    1130                 1135                 1140             


Lys Val  Lys Glu Tyr Asn Asn  Leu Leu Asn Ala Leu  Gln Met Asp 
    1145                 1150                 1155             


Ser Asp  Glu Met Lys Lys Ile  Leu Ala Glu Asn Ser  Arg Lys Ile 
    1160                 1165                 1170             


Thr Val  Leu Gln Val Asn Glu  Lys Ser Leu Ile Arg  Gln Tyr Thr 
    1175                 1180                 1185             


Thr Leu  Val Glu Leu Glu Arg  Gln Leu Arg Lys Glu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Lys  Asn Glu Leu Leu Ser  Met Glu Ala Glu Val  Cys Glu Lys 
    1205                 1210                 1215             


Ile Gly  Cys Leu Gln Arg Phe  Lys Glu Met Ala Ile  Phe Lys Ile 
    1220                 1225                 1230             


Ala Ala  Leu Gln Lys Val Val  Asp Asn Ser Val Ser  Leu Ser Glu 
    1235                 1240                 1245             


Leu Glu  Leu Ala Asn Lys Gln  Tyr Asn Glu Leu Thr  Ala Lys Tyr 
    1250                 1255                 1260             


Arg Asp  Ile Leu Gln Lys Asp  Asn Met Leu Val Gln  Arg Thr Ser 
    1265                 1270                 1275             


Asn Leu  Glu His Leu Glu Cys  Glu Asn Ile Ser Leu  Lys Glu Gln 
    1280                 1285                 1290             


Val Glu  Ser Ile Asn Lys Glu  Leu Glu Ile Thr Lys  Glu Lys Leu 
    1295                 1300                 1305             


His Thr  Ile Glu Gln Ala Trp  Glu Gln Glu Thr Lys  Leu Gly Asn 
    1310                 1315                 1320             


Glu Ser  Ser Met Asp Lys Ala  Lys Lys Ser Ile Thr  Asn Ser Asp 
    1325                 1330                 1335             


Ile Val  Ser Ile Ser Lys Lys  Ile Thr Met Leu Glu  Met Lys Glu 
    1340                 1345                 1350             


Leu Asn  Glu Arg Gln Arg Ala  Glu His Cys Gln Lys  Met Tyr Glu 
    1355                 1360                 1365             


His Leu  Arg Thr Ser Leu Lys  Gln Met Glu Glu Arg  Asn Phe Glu 
    1370                 1375                 1380             


Leu Glu  Thr Lys Phe Ala Glu  Leu Thr Lys Ile Asn  Leu Asp Ala 
    1385                 1390                 1395             


Gln Lys  Val Glu Gln Met Leu  Arg Asp Glu Leu Ala  Asp Ser Val 
    1400                 1405                 1410             


Ser Lys  Ala Val Ser Asp Ala  Asp Arg Gln Arg Ile  Leu Glu Leu 
    1415                 1420                 1425             


Glu Lys  Asn Glu Met Glu Leu  Lys Val Glu Val Ser  Lys Leu Arg 
    1430                 1435                 1440             


Glu Ile  Ser Asp Ile Ala Arg  Arg Gln Val Glu Ile  Leu Asn Ala 
    1445                 1450                 1455             


Gln Gln  Gln Ser Arg Asp Lys  Glu Val Glu Ser Leu  Arg Met Gln 
    1460                 1465                 1470             


Leu Leu  Asp Tyr Gln Ala Gln  Ser Asp Glu Lys Ser  Leu Ile Ala 
    1475                 1480                 1485             


Lys Leu  His Gln His Asn Val  Ser Leu Gln Leu Ser  Glu Ala Thr 
    1490                 1495                 1500             


Ala Leu  Gly Lys Leu Glu Ser  Ile Thr Ser Lys Leu  Gln Lys Met 
    1505                 1510                 1515             


Glu Ala  Tyr Asn Leu Arg Leu  Glu Gln Lys Leu Asp  Glu Lys Glu 
    1520                 1525                 1530             


Gln Ala  Leu Tyr Tyr Ala Arg  Leu Glu Gly Arg Asn  Arg Ala Lys 
    1535                 1540                 1545             


His Leu  Arg Gln Thr Ile Gln  Ser Leu Arg Arg Gln  Phe Ser Gly 
    1550                 1555                 1560             


Ala Leu  Pro Leu Ala Gln Gln  Glu Lys Phe Ser Lys  Thr Met Ile 
    1565                 1570                 1575             


Gln Leu  Gln Asn Asp Lys Leu  Lys Ile Met Gln Glu  Met Lys Asn 
    1580                 1585                 1590             


Ser Gln  Gln Glu His Arg Asn  Met Glu Asn Lys Thr  Leu Glu Met 
    1595                 1600                 1605             


Glu Leu  Lys Leu Lys Gly Leu  Glu Glu Leu Ile Ser  Thr Leu Lys 
    1610                 1615                 1620             


Asp Thr  Lys Gly Ala Gln Lys  Val Ile Asn Trp His  Met Lys Ile 
    1625                 1630                 1635             


Glu Glu  Leu Arg Leu Gln Glu  Leu Lys Leu Asn Arg  Glu Leu Val 
    1640                 1645                 1650             


Lys Asp  Lys Glu Glu Ile Lys  Tyr Leu Asn Asn Ile  Ile Ser Glu 
    1655                 1660                 1665             


Tyr Glu  Arg Thr Ile Ser Ser  Leu Glu Glu Glu Ile  Val Gln Gln 
    1670                 1675                 1680             


Asn Lys  Phe His Glu Glu Arg  Gln Met Ala Trp Asp  Gln Arg Glu 
    1685                 1690                 1695             


Val Asp  Leu Glu Arg Gln Leu  Asp Ile Phe Asp Arg  Gln Gln Asn 
    1700                 1705                 1710             


Glu Ile  Leu Asn Ala Ala Gln  Lys Phe Glu Glu Ala  Thr Gly Ser 
    1715                 1720                 1725             


Ile Pro  Asp Pro Ser Leu Pro  Leu Pro Asn Gln Leu  Glu Ile Ala 
    1730                 1735                 1740             


Leu Arg  Lys Ile Lys Glu Asn  Ile Arg Ile Ile Leu  Glu Thr Arg 
    1745                 1750                 1755             


Ala Thr  Cys Lys Ser Leu Glu  Glu Lys Leu Lys Glu  Lys Glu Ser 
    1760                 1765                 1770             


Ala Leu  Arg Leu Ala Glu Gln  Asn Ile Leu Ser Arg  Asp Lys Val 
    1775                 1780                 1785             


Ile Asn  Glu Leu Arg Leu Arg  Leu Pro Ala Thr Ala  Glu Arg Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ala Glu Leu Gly  Arg Lys Glu Met Glu  Pro Lys Ser 
    1805                 1810                 1815             


His His  Thr Leu Lys Ile Ala  His Gln Thr Ile Ala  Asn Met Gln 
    1820                 1825                 1830             


Ala Arg  Leu Asn Gln Lys Glu  Glu Val Leu Lys Lys  Tyr Gln Arg 
    1835                 1840                 1845             


Leu Leu  Glu Lys Ala Arg Glu  Glu Gln Arg Glu Ile  Val Lys Lys 
    1850                 1855                 1860             


His Glu  Glu Asp Leu His Ile  Leu His His Arg Leu  Glu Leu Gln 
    1865                 1870                 1875             


Ala Asp  Ser Ser Leu Asn Lys  Phe Lys Gln Thr Ala  Trp Asp Leu 
    1880                 1885                 1890             


Met Lys  Gln Ser Pro Thr Pro  Val Pro Thr Asn Lys  His Phe Ile 
    1895                 1900                 1905             


Arg Leu  Ala Glu Met Glu Gln  Thr Val Ala Glu Gln  Asp Asp Ser 
    1910                 1915                 1920             


Leu Ser  Ser Leu Leu Val Lys  Leu Lys Lys Val Ser  Gln Asp Leu 
    1925                 1930                 1935             


Glu Arg  Gln Arg Glu Ile Thr  Glu Leu Lys Val Lys  Glu Phe Glu 
    1940                 1945                 1950             


Asn Ile  Lys Leu Gln Leu Gln  Glu Asn His Glu Asp  Glu Val Lys 
    1955                 1960                 1965             


Lys Val  Lys Ala Glu Val Glu  Asp Leu Lys Tyr Leu  Leu Asp Gln 
    1970                 1975                 1980             


Ser Gln  Lys Glu Ser Gln Cys  Leu Lys Ser Glu Leu  Gln Ala Gln 
    1985                 1990                 1995             


Lys Glu  Ala Asn Ser Arg Ala  Pro Thr Thr Thr Met  Arg Asn Leu 
    2000                 2005                 2010             


Val Glu  Arg Leu Lys Ser Gln  Leu Ala Leu Lys Glu  Lys Gln Gln 
    2015                 2020                 2025             


Lys Ala  Leu Ser Arg Ala Leu  Leu Glu Leu Arg Ala  Glu Met Thr 
    2030                 2035                 2040             


Ala Ala  Ala Glu Glu Arg Ile  Ile Ser Ala Thr Ser  Gln Lys Glu 
    2045                 2050                 2055             


Ala His  Leu Asn Val Gln Gln  Ile Val Asp Arg His  Thr Arg Glu 
    2060                 2065                 2070             


Leu Lys  Thr Gln Val Glu Asp  Leu Asn Glu Asn Leu  Leu Lys Leu 
    2075                 2080                 2085             


Lys Glu  Ala Leu Lys Thr Ser  Lys Asn Arg Glu Asn  Ser Leu Thr 
    2090                 2095                 2100             


Asp Asn  Leu Asn Asp Leu Asn  Asn Glu Leu Gln Lys  Lys Gln Lys 
    2105                 2110                 2115             


Ala Tyr  Asn Lys Ile Leu Arg  Glu Lys Glu Glu Ile  Asp Gln Glu 
    2120                 2125                 2130             


Asn Asp  Glu Leu Lys Arg Gln  Ile Lys Arg Leu Thr  Ser Gly Leu 
    2135                 2140                 2145             


Gln Gly  Lys Pro Leu Thr Asp  Asn Lys Gln Ser Leu  Ile Glu Glu 
    2150                 2155                 2160             


Leu Gln  Arg Lys Val Lys Lys  Leu Glu Asn Gln Leu  Glu Gly Lys 
    2165                 2170                 2175             


Val Glu  Glu Val Asp Leu Lys  Pro Met Lys Glu Lys  Asn Ala Lys 
    2180                 2185                 2190             


Glu Glu  Leu Ile Arg Trp Glu  Glu Gly Lys Lys Trp  Gln Ala Lys 
    2195                 2200                 2205             


Ile Glu  Gly Ile Arg Asn Lys  Leu Lys Glu Lys Glu  Gly Glu Val 
    2210                 2215                 2220             


Phe Thr  Leu Thr Lys Gln Leu  Asn Thr Leu Lys Asp  Leu Phe Ala 
    2225                 2230                 2235             


Lys Ala  Asp Lys Glu Lys Leu  Thr Leu Gln Arg Lys  Leu Lys Thr 
    2240                 2245                 2250             


Thr Gly  Met Thr Val Asp Gln  Val Leu Gly Ile Arg  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Lys Glu Leu Glu Glu  Leu Lys Lys Arg Asn  Leu Asp Leu 
    2270                 2275                 2280             


Glu Asn  Asp Ile Leu Tyr Met  Arg Ala His Gln Ala  Leu Pro Arg 
    2285                 2290                 2295             


Asp Ser  Val Val Glu Asp Leu  His Leu Gln Asn Arg  Tyr Leu Gln 
    2300                 2305                 2310             


Glu Lys  Leu His Ala Leu Glu  Lys Gln Phe Ser Lys  Asp Thr Tyr 
    2315                 2320                 2325             


Ser Lys  Pro Ser Asn Gln Asp  Thr Ser His Ser Arg  Ile Gly Phe 
    2330                 2335                 2340             


Thr Leu  Lys Ser His Phe Asn  Leu Asn Thr Ser Val  Lys Thr Gln 
    2345                 2350                 2355             


Ser Pro  Asn Lys Val Thr Phe  
    2360                 2365 


<210>  76
<211>  2256
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CENTROSOMAL PROTEIN 290 (CEP290), ISOFORM X14 <Accession 
No.: XP_011537068.1>

<400>  76

Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln Gln 
1               5                   10                  15      


Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser Leu 
            20                  25                  30          


Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala Gln 
        35                  40                  45              


Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp Leu 
    50                  55                  60                  


Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg Lys 
65                  70                  75                  80  


Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys Ile 
                85                  90                  95      


Arg Ser Ser Asp Lys Ala Glu Leu Leu His Arg Arg Ser Ser Phe Asn 
            100                 105                 110         


Thr Pro Gln Ser Asp Gln Asn Glu Thr Glu Glu Asn Met Thr Ile Gly 
        115                 120                 125             


Ser Leu Ser Arg Met Leu Ser Glu Ile His His Ser Val Glu Ser Gly 
    130                 135                 140                 


Met His Pro Phe Val Pro Leu Thr Arg Leu Ser Ser Ser Met Gln Val 
145                 150                 155                 160 


Lys Glu Asn Ser Thr Pro Glu Thr Ile Thr Ile Arg Glu Ile Phe Lys 
                165                 170                 175     


Ala Pro Cys Leu Gln Ser Ser Arg Asn Leu Glu Ser Leu Val Ser Thr 
            180                 185                 190         


Phe Ser Arg Glu Ser His Glu Glu Ile Asn Asp Ile Cys Leu Phe Ser 
        195                 200                 205             


Asp Asp Cys Met Lys Lys Val Ser Arg Ser His Gln Ala Leu Glu Lys 
    210                 215                 220                 


Thr Ser Phe Val Gln Lys Ser Asn Ser Ser Phe His Gly Leu Ser Thr 
225                 230                 235                 240 


Ala Ser Asp Ile Met Gln Lys Leu Ser Leu Arg Gln Lys Ser Ala Ile 
                245                 250                 255     


Phe Cys Gln Gln Ile His Glu Asn Arg Ala Asp Met Asp Lys Ser Gln 
            260                 265                 270         


Val Ala Thr Leu Glu Glu Glu Gln Val His Ser Gln Val Lys Tyr Ala 
        275                 280                 285             


Asp Ile Asn Leu Lys Glu Asp Ile Ile Lys Ser Glu Val Pro Leu Gln 
    290                 295                 300                 


Thr Glu Ile Leu Lys Asn Lys Leu Lys Val Asn Leu Pro Asp Pro Val 
305                 310                 315                 320 


Ser Ile Thr Ala Gln Ser Lys Leu Ser Gln Ile Asn Ser Leu Glu Asn 
                325                 330                 335     


Leu Ile Glu Gln Leu Arg Arg Glu Leu Val Phe Leu Arg Ser Gln Asn 
            340                 345                 350         


Glu Ile Ile Ala Gln Glu Phe Leu Ile Lys Glu Ala Glu Cys Arg Asn 
        355                 360                 365             


Ala Asp Ile Glu Leu Glu His His Arg Ser Gln Ala Glu Gln Asn Glu 
    370                 375                 380                 


Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg Ser 
385                 390                 395                 400 


Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val Glu 
                405                 410                 415     


Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala Ile 
            420                 425                 430         


Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser Leu 
        435                 440                 445             


Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys Asn 
    450                 455                 460                 


Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val Asp 
465                 470                 475                 480 


Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg Glu Ser 
                485                 490                 495     


Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala Asn Leu 
            500                 505                 510         


Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln Ser Glu 
        515                 520                 525             


Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly Ile Ala 
    530                 535                 540                 


Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu Ile His 
545                 550                 555                 560 


Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn Leu Glu 
                565                 570                 575     


Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg His Gln 
            580                 585                 590         


Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr Trp Lys 
        595                 600                 605             


Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu Asp Gln 
    610                 615                 620                 


Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu Leu Asn 
625                 630                 635                 640 


Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala Glu Asn 
                645                 650                 655     


Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu Ile Arg 
            660                 665                 670         


Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys Glu Asn 
        675                 680                 685             


Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val Cys Glu 
    690                 695                 700                 


Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe Lys Ile 
705                 710                 715                 720 


Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser Glu Leu 
                725                 730                 735     


Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr Arg Asp 
            740                 745                 750         


Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn Leu Glu 
        755                 760                 765             


His Leu Glu Cys Glu Asn Ile Ser Leu Lys Glu Gln Val Glu Ser Ile 
    770                 775                 780                 


Asn Lys Glu Leu Glu Ile Thr Lys Glu Lys Leu His Thr Ile Glu Gln 
785                 790                 795                 800 


Ala Trp Glu Gln Glu Thr Lys Leu Gly Asn Glu Ser Ser Met Asp Lys 
                805                 810                 815     


Ala Lys Lys Ser Ile Thr Asn Ser Asp Ile Val Ser Ile Ser Lys Lys 
            820                 825                 830         


Ile Thr Met Leu Glu Met Lys Glu Leu Asn Glu Arg Gln Arg Ala Glu 
        835                 840                 845             


His Cys Gln Lys Met Tyr Glu His Leu Arg Thr Ser Leu Lys Gln Met 
    850                 855                 860                 


Glu Glu Arg Asn Phe Glu Leu Glu Thr Lys Phe Ala Glu Leu Thr Lys 
865                 870                 875                 880 


Ile Asn Leu Asp Ala Gln Lys Val Glu Gln Met Leu Arg Asp Glu Leu 
                885                 890                 895     


Ala Asp Ser Val Ser Lys Ala Val Ser Asp Ala Asp Arg Gln Arg Ile 
            900                 905                 910         


Leu Glu Leu Glu Lys Asn Glu Met Glu Leu Lys Val Glu Val Ser Lys 
        915                 920                 925             


Leu Arg Glu Ile Ser Asp Ile Ala Arg Arg Gln Val Glu Ile Leu Asn 
    930                 935                 940                 


Ala Gln Gln Gln Ser Arg Asp Lys Glu Val Glu Ser Leu Arg Met Gln 
945                 950                 955                 960 


Leu Leu Asp Tyr Gln Ala Gln Ser Asp Glu Lys Ser Leu Ile Ala Lys 
                965                 970                 975     


Leu His Gln His Asn Val Ser Leu Gln Leu Ser Glu Ala Thr Ala Leu 
            980                 985                 990         


Gly Lys Leu Glu Ser Ile Thr Ser  Lys Leu Gln Lys Met  Glu Ala Tyr 
        995                 1000                 1005             


Asn Leu  Arg Leu Glu Gln Lys  Leu Asp Glu Lys Glu  Gln Ala Leu 
    1010                 1015                 1020             


Tyr Tyr  Ala Arg Leu Glu Gly  Arg Asn Arg Ala Lys  His Leu Arg 
    1025                 1030                 1035             


Gln Thr  Ile Gln Ser Leu Arg  Arg Gln Phe Ser Gly  Ala Leu Pro 
    1040                 1045                 1050             


Leu Ala  Gln Gln Glu Lys Phe  Ser Lys Thr Met Ile  Gln Leu Gln 
    1055                 1060                 1065             


Asn Asp  Lys Leu Lys Ile Met  Gln Glu Met Lys Asn  Ser Gln Gln 
    1070                 1075                 1080             


Glu His  Arg Asn Met Glu Asn  Lys Thr Leu Glu Met  Glu Leu Lys 
    1085                 1090                 1095             


Leu Lys  Gly Leu Glu Glu Leu  Ile Ser Thr Leu Lys  Asp Thr Lys 
    1100                 1105                 1110             


Gly Ala  Gln Lys Val Ile Asn  Trp His Met Lys Ile  Glu Glu Leu 
    1115                 1120                 1125             


Arg Leu  Gln Glu Leu Lys Leu  Asn Arg Glu Leu Val  Lys Asp Lys 
    1130                 1135                 1140             


Glu Glu  Ile Lys Tyr Leu Asn  Asn Ile Ile Ser Glu  Tyr Glu Arg 
    1145                 1150                 1155             


Thr Ile  Ser Ser Leu Glu Glu  Glu Ile Val Gln Gln  Asn Lys Phe 
    1160                 1165                 1170             


His Glu  Glu Arg Gln Met Ala  Trp Asp Gln Arg Glu  Val Asp Leu 
    1175                 1180                 1185             


Glu Arg  Gln Leu Asp Ile Phe  Asp Arg Gln Gln Asn  Glu Ile Leu 
    1190                 1195                 1200             


Asn Ala  Ala Gln Lys Phe Glu  Glu Ala Thr Gly Ser  Ile Pro Asp 
    1205                 1210                 1215             


Pro Ser  Leu Pro Leu Pro Asn  Gln Leu Glu Ile Ala  Leu Arg Lys 
    1220                 1225                 1230             


Ile Lys  Glu Asn Ile Arg Ile  Ile Leu Glu Thr Arg  Ala Thr Cys 
    1235                 1240                 1245             


Lys Ser  Leu Glu Glu Lys Leu  Lys Glu Lys Glu Ser  Ala Leu Arg 
    1250                 1255                 1260             


Leu Ala  Glu Gln Asn Ile Leu  Ser Arg Asp Lys Val  Ile Asn Glu 
    1265                 1270                 1275             


Leu Arg  Leu Arg Leu Pro Ala  Thr Ala Glu Arg Glu  Lys Leu Ile 
    1280                 1285                 1290             


Ala Glu  Leu Gly Arg Lys Glu  Met Glu Pro Lys Ser  His His Thr 
    1295                 1300                 1305             


Leu Lys  Ile Ala His Gln Thr  Ile Ala Asn Met Gln  Ala Arg Leu 
    1310                 1315                 1320             


Asn Gln  Lys Glu Glu Val Leu  Lys Lys Tyr Gln Arg  Leu Leu Glu 
    1325                 1330                 1335             


Lys Ala  Arg Glu Glu Gln Arg  Glu Ile Val Lys Lys  His Glu Glu 
    1340                 1345                 1350             


Asp Leu  His Ile Leu His His  Arg Leu Glu Leu Gln  Ala Asp Ser 
    1355                 1360                 1365             


Ser Leu  Asn Lys Phe Lys Gln  Thr Ala Trp Asp Leu  Met Lys Gln 
    1370                 1375                 1380             


Ser Pro  Thr Pro Val Pro Thr  Asn Lys His Phe Ile  Arg Leu Ala 
    1385                 1390                 1395             


Glu Met  Glu Gln Thr Val Ala  Glu Gln Asp Asp Ser  Leu Ser Ser 
    1400                 1405                 1410             


Leu Leu  Val Lys Leu Lys Lys  Val Ser Gln Asp Leu  Glu Arg Gln 
    1415                 1420                 1425             


Arg Glu  Ile Thr Glu Leu Lys  Val Lys Glu Phe Glu  Asn Ile Lys 
    1430                 1435                 1440             


Leu Gln  Leu Gln Glu Asn His  Glu Asp Glu Val Lys  Lys Val Lys 
    1445                 1450                 1455             


Ala Glu  Val Glu Asp Leu Lys  Tyr Leu Leu Asp Gln  Ser Gln Lys 
    1460                 1465                 1470             


Glu Ser  Gln Cys Leu Lys Ser  Glu Leu Gln Ala Gln  Lys Glu Ala 
    1475                 1480                 1485             


Asn Ser  Arg Ala Pro Thr Thr  Thr Met Arg Asn Leu  Val Glu Arg 
    1490                 1495                 1500             


Leu Lys  Ser Gln Leu Ala Leu  Lys Glu Lys Gln Gln  Lys Ala Leu 
    1505                 1510                 1515             


Ser Arg  Ala Leu Leu Glu Leu  Arg Ala Glu Met Thr  Ala Ala Ala 
    1520                 1525                 1530             


Glu Glu  Arg Ile Ile Ser Ala  Thr Ser Gln Lys Glu  Ala His Leu 
    1535                 1540                 1545             


Asn Val  Gln Gln Ile Val Asp  Arg His Thr Arg Glu  Leu Lys Thr 
    1550                 1555                 1560             


Gln Val  Glu Asp Leu Asn Glu  Asn Leu Leu Lys Leu  Lys Glu Ala 
    1565                 1570                 1575             


Leu Lys  Thr Ser Lys Asn Arg  Glu Asn Ser Leu Thr  Asp Asn Leu 
    1580                 1585                 1590             


Asn Asp  Leu Asn Asn Glu Leu  Gln Lys Lys Gln Lys  Ala Tyr Asn 
    1595                 1600                 1605             


Lys Ile  Leu Arg Glu Lys Glu  Glu Ile Asp Gln Glu  Asn Asp Glu 
    1610                 1615                 1620             


Leu Lys  Arg Gln Ile Lys Arg  Leu Thr Ser Gly Leu  Gln Gly Lys 
    1625                 1630                 1635             


Pro Leu  Thr Asp Asn Lys Gln  Ser Leu Ile Glu Glu  Leu Gln Arg 
    1640                 1645                 1650             


Lys Val  Lys Lys Leu Glu Asn  Gln Leu Glu Gly Lys  Val Glu Glu 
    1655                 1660                 1665             


Val Asp  Leu Lys Pro Met Lys  Glu Lys Asn Ala Lys  Glu Glu Leu 
    1670                 1675                 1680             


Ile Arg  Trp Glu Glu Gly Lys  Lys Trp Gln Ala Lys  Ile Glu Gly 
    1685                 1690                 1695             


Ile Arg  Asn Lys Leu Lys Glu  Lys Glu Gly Glu Val  Phe Thr Leu 
    1700                 1705                 1710             


Thr Lys  Gln Leu Asn Thr Leu  Lys Asp Leu Phe Ala  Lys Ala Asp 
    1715                 1720                 1725             


Lys Glu  Lys Leu Thr Leu Gln  Arg Lys Leu Lys Thr  Thr Gly Met 
    1730                 1735                 1740             


Thr Val  Asp Gln Val Leu Gly  Ile Arg Ala Leu Glu  Ser Glu Lys 
    1745                 1750                 1755             


Glu Leu  Glu Glu Leu Lys Lys  Arg Asn Leu Asp Leu  Glu Asn Asp 
    1760                 1765                 1770             


Ile Leu  Tyr Met Arg Ala His  Gln Ala Leu Pro Arg  Asp Ser Val 
    1775                 1780                 1785             


Val Glu  Asp Leu His Leu Gln  Asn Arg Tyr Leu Gln  Glu Lys Leu 
    1790                 1795                 1800             


His Ala  Leu Glu Lys Gln Phe  Ser Lys Asp Thr Tyr  Ser Lys Pro 
    1805                 1810                 1815             


Ser Gln  Asn Gln Ile Ser Gly  Ile Glu Ser Asp Asp  His Cys Gln 
    1820                 1825                 1830             


Arg Glu  Gln Glu Leu Gln Lys  Glu Asn Leu Lys Leu  Ser Ser Glu 
    1835                 1840                 1845             


Asn Ile  Glu Leu Lys Phe Gln  Leu Glu Gln Ala Asn  Lys Asp Leu 
    1850                 1855                 1860             


Pro Arg  Leu Lys Asn Gln Val  Arg Asp Leu Lys Glu  Met Cys Glu 
    1865                 1870                 1875             


Phe Leu  Lys Lys Glu Lys Ala  Glu Val Gln Arg Lys  Leu Gly His 
    1880                 1885                 1890             


Val Arg  Gly Ser Gly Arg Ser  Gly Lys Thr Ile Pro  Glu Leu Glu 
    1895                 1900                 1905             


Lys Thr  Ile Gly Leu Met Lys  Lys Val Val Glu Lys  Val Gln Arg 
    1910                 1915                 1920             


Glu Asn  Glu Gln Leu Lys Lys  Ala Ser Gly Ile Leu  Thr Ser Glu 
    1925                 1930                 1935             


Lys Met  Ala Asn Ile Glu Gln  Glu Asn Glu Lys Leu  Lys Ala Glu 
    1940                 1945                 1950             


Leu Glu  Lys Leu Lys Ala His  Leu Gly His Gln Leu  Ser Met His 
    1955                 1960                 1965             


Tyr Glu  Ser Lys Thr Lys Gly  Thr Glu Lys Ile Ile  Ala Glu Asn 
    1970                 1975                 1980             


Glu Arg  Leu Arg Lys Glu Leu  Lys Lys Glu Thr Asp  Ala Ala Glu 
    1985                 1990                 1995             


Lys Leu  Arg Ile Ala Lys Asn  Asn Leu Glu Ile Leu  Asn Glu Lys 
    2000                 2005                 2010             


Met Thr  Val Gln Leu Glu Glu  Thr Gly Lys Arg Leu  Gln Phe Ala 
    2015                 2020                 2025             


Glu Ser  Arg Gly Pro Gln Leu  Glu Gly Ala Asp Ser  Lys Ser Trp 
    2030                 2035                 2040             


Lys Ser  Ile Val Val Thr Arg  Met Tyr Glu Thr Lys  Leu Lys Glu 
    2045                 2050                 2055             


Leu Glu  Thr Asp Ile Ala Lys  Lys Asn Gln Ser Ile  Thr Asp Leu 
    2060                 2065                 2070             


Lys Gln  Leu Val Lys Glu Ala  Thr Glu Arg Glu Gln  Lys Val Asn 
    2075                 2080                 2085             


Lys Tyr  Asn Glu Asp Leu Glu  Gln Gln Ile Lys Ile  Leu Lys His 
    2090                 2095                 2100             


Val Pro  Glu Gly Ala Glu Thr  Glu Gln Gly Leu Lys  Arg Glu Leu 
    2105                 2110                 2115             


Gln Val  Leu Arg Leu Ala Asn  His Gln Leu Asp Lys  Glu Lys Ala 
    2120                 2125                 2130             


Glu Leu  Ile His Gln Ile Glu  Ala Asn Lys Asp Gln  Ser Gly Ala 
    2135                 2140                 2145             


Glu Ser  Thr Ile Pro Asp Ala  Asp Gln Leu Lys Glu  Lys Ile Lys 
    2150                 2155                 2160             


Asp Leu  Glu Thr Gln Leu Lys  Met Ser Asp Leu Glu  Lys Gln His 
    2165                 2170                 2175             


Leu Lys  Glu Glu Ile Lys Lys  Leu Lys Lys Glu Leu  Glu Asn Phe 
    2180                 2185                 2190             


Asp Pro  Ser Phe Phe Glu Glu  Ile Glu Asp Leu Lys  Tyr Asn Tyr 
    2195                 2200                 2205             


Lys Glu  Glu Val Lys Lys Asn  Ile Leu Leu Glu Glu  Lys Val Lys 
    2210                 2215                 2220             


Lys Leu  Ser Glu Gln Leu Gly  Val Glu Leu Thr Ser  Pro Val Ala 
    2225                 2230                 2235             


Ala Ser  Glu Glu Phe Glu Asp  Glu Glu Glu Ser Pro  Val Asn Phe 
    2240                 2245                 2250             


Pro Ile  Tyr 
    2255     


<210>  77
<211>  599
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INOSINE MONOPHOSPHATE DEHYDROGENASE 1 (IMPDH1) <Accession 
No.: EAL24310.1>

<400>  77

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Pro Arg Leu Asp Leu Ala Thr His Pro Thr Thr Pro Arg Ser Glu 
    50                  55                  60                  


Leu Ser Ser Val Val Leu Leu Ala Gly Val Gly Val Gln Met Asp Arg 
65                  70                  75                  80  


Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly 
                85                  90                  95      


Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala 
            100                 105                 110         


Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp 
        115                 120                 125             


Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile 
    130                 135                 140                 


Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu 
145                 150                 155                 160 


Ala Asp Met Ala Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile 
                165                 170                 175     


His His Asn Cys Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val 
            180                 185                 190         


Lys Lys Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro 
        195                 200                 205             


Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe 
    210                 215                 220                 


Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val 
225                 230                 235                 240 


Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His 
                245                 250                 255     


Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val 
            260                 265                 270         


Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg 
        275                 280                 285             


Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val 
    290                 295                 300                 


Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu 
305                 310                 315                 320 


Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly 
                325                 330                 335     


Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly 
            340                 345                 350         


Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln 
        355                 360                 365             


Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val 
    370                 375                 380                 


Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp 
385                 390                 395                 400 


Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys 
                405                 410                 415     


Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val 
            420                 425                 430         


Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala 
        435                 440                 445             


Asp Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu 
    450                 455                 460                 


Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu 
465                 470                 475                 480 


Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr 
                485                 490                 495     


Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln 
            500                 505                 510         


Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val 
        515                 520                 525             


Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr 
    530                 535                 540                 


Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser 
545                 550                 555                 560 


Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu 
                565                 570                 575     


Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His 
            580                 585                 590         


Ser Tyr Glu Lys Arg Leu Tyr 
        595                 


<210>  78
<211>  563
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INOSINE MONOPHOSPHATE DEHYDROGENASE 1 (IMPDH1) 
<Accession No.: AAH33622.2>

<400>  78

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly Tyr Val Pro Glu 
    50                  55                  60                  


Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala Asp Gly Leu Thr 
65                  70                  75                  80  


Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp Phe Ile Ala Asp 
                85                  90                  95      


Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile Thr Leu Lys Thr 
            100                 105                 110         


Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu Ala Asp Met Ala 
        115                 120                 125             


Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile His His Asn Cys 
    130                 135                 140                 


Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val Lys Lys Phe Glu 
145                 150                 155                 160 


Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro Ser His Thr Val 
                165                 170                 175     


Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe Ser Gly Ile Pro 
            180                 185                 190         


Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val Gly Ile Val Thr 
        195                 200                 205             


Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His Thr Thr Leu Leu 
    210                 215                 220                 


Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val Ala Pro Ala Gly 
225                 230                 235                 240 


Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly 
                245                 250                 255     


Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val Ala Ile Ile Ala 
            260                 265                 270         


Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp 
        275                 280                 285             


Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly Thr Arg Glu Asp 
    290                 295                 300                 


Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly Val Asp Val Ile 
305                 310                 315                 320 


Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln Ile Ala Met Val 
                325                 330                 335     


His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val Ile Gly Gly Asn 
            340                 345                 350         


Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp 
        355                 360                 365             


Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys Ile Thr Gln Glu 
    370                 375                 380                 


Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val Tyr Lys Val Ala 
385                 390                 395                 400 


Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala Asp Gly Gly Ile 
                405                 410                 415     


Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu Gly Ala Ser Thr 
            420                 425                 430         


Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu 
        435                 440                 445             


Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr Arg Gly Met Gly 
    450                 455                 460                 


Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln Lys Arg Tyr Phe 
465                 470                 475                 480 


Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val Ser Gly Ser Ile 
                485                 490                 495     


Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr Leu Ile Ala Gly 
            500                 505                 510         


Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser Leu Ser Val Leu 
        515                 520                 525             


Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Met 
    530                 535                 540                 


Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His Ser Tyr Glu Lys 
545                 550                 555                 560 


Arg Leu Tyr 
            


<210>  79
<211>  561
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INOSINE MONOPHOSPHATE DEHYDROGENASE 1 (IMPDH1), 
ISOFORM CRA_A <Accession No.: EAW83649.1>

<400>  79

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly Tyr Val Pro Glu 
    50                  55                  60                  


Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala Asp Gly Leu Thr 
65                  70                  75                  80  


Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp Phe Ile Ala Asp 
                85                  90                  95      


Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile Thr Leu Lys Thr 
            100                 105                 110         


Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu Ala Asp Met Ala 
        115                 120                 125             


Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile His His Asn Cys 
    130                 135                 140                 


Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Lys Phe Glu Gln Gly 
145                 150                 155                 160 


Phe Ile Thr Asp Pro Val Val Leu Ser Pro Ser His Thr Val Gly Asp 
                165                 170                 175     


Val Leu Glu Ala Lys Met Arg His Gly Phe Ser Gly Ile Pro Ile Thr 
            180                 185                 190         


Glu Thr Gly Thr Met Gly Ser Lys Leu Val Gly Ile Val Thr Ser Arg 
        195                 200                 205             


Asp Ile Asp Phe Leu Ala Glu Lys Asp His Thr Thr Leu Leu Ser Glu 
    210                 215                 220                 


Val Met Thr Pro Arg Ile Glu Leu Val Val Ala Pro Ala Gly Val Thr 
225                 230                 235                 240 


Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys Leu 
                245                 250                 255     


Pro Ile Val Asn Asp Cys Asp Glu Leu Val Ala Ile Ile Ala Arg Thr 
            260                 265                 270         


Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ser Gln 
        275                 280                 285             


Lys Gln Leu Leu Cys Gly Ala Ala Val Gly Thr Arg Glu Asp Asp Lys 
    290                 295                 300                 


Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly Val Asp Val Ile Val Leu 
305                 310                 315                 320 


Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln Ile Ala Met Val His Tyr 
                325                 330                 335     


Ile Lys Gln Lys Tyr Pro His Leu Gln Val Ile Gly Gly Asn Val Val 
            340                 345                 350         


Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp Gly Leu 
        355                 360                 365             


Arg Val Gly Met Gly Cys Gly Ser Ile Cys Ile Thr Gln Glu Val Met 
    370                 375                 380                 


Ala Cys Gly Arg Pro Gln Gly Thr Ala Val Tyr Lys Val Ala Glu Tyr 
385                 390                 395                 400 


Ala Arg Arg Phe Gly Val Pro Ile Ile Ala Asp Gly Gly Ile Gln Thr 
                405                 410                 415     


Val Gly His Val Val Lys Ala Leu Ala Leu Gly Ala Ser Thr Val Met 
            420                 425                 430         


Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr Phe 
        435                 440                 445             


Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser Leu 
    450                 455                 460                 


Asp Ala Met Glu Lys Ser Ser Ser Ser Gln Lys Arg Tyr Phe Ser Glu 
465                 470                 475                 480 


Gly Asp Lys Val Lys Ile Ala Gln Gly Val Ser Gly Ser Ile Gln Asp 
                485                 490                 495     


Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile Gln 
            500                 505                 510         


His Gly Cys Gln Asp Ile Gly Ala Arg Ser Leu Ser Val Leu Arg Ser 
        515                 520                 525             


Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Met Ser Ala 
    530                 535                 540                 


Gln Ile Glu Gly Gly Val His Gly Leu His Ser Tyr Glu Lys Arg Leu 
545                 550                 555                 560 


Tyr 
    


<210>  80
<211>  497
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INOSINE MONOPHOSPHATE DEHYDROGENASE 1 (IMPDH1), 
ISOFORM CRA_B <Accession No.: EAW83650.1>

<400>  80

Met Asp Arg Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly 
1               5                   10                  15      


Gly Thr Gly Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe 
            20                  25                  30          


Ala Ser Ala Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly 
        35                  40                  45              


Phe Ile Asp Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr 
    50                  55                  60                  


Arg Lys Ile Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr 
65                  70                  75                  80  


Val Thr Glu Ala Asp Met Ala Ile Ala Met Ala Lys Phe Glu Gln Gly 
                85                  90                  95      


Phe Ile Thr Asp Pro Val Val Leu Ser Pro Ser His Thr Val Gly Asp 
            100                 105                 110         


Val Leu Glu Ala Lys Met Arg His Gly Phe Ser Gly Ile Pro Ile Thr 
        115                 120                 125             


Glu Thr Gly Thr Met Gly Ser Lys Leu Val Gly Ile Val Thr Ser Arg 
    130                 135                 140                 


Asp Ile Asp Phe Leu Ala Glu Lys Asp His Thr Thr Leu Leu Ser Glu 
145                 150                 155                 160 


Val Met Thr Pro Arg Ile Glu Leu Val Val Ala Pro Ala Gly Val Thr 
                165                 170                 175     


Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys Leu 
            180                 185                 190         


Pro Ile Val Asn Asp Cys Asp Glu Leu Val Ala Ile Ile Ala Arg Thr 
        195                 200                 205             


Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ser Gln 
    210                 215                 220                 


Lys Gln Leu Leu Cys Gly Ala Ala Val Gly Thr Arg Glu Asp Asp Lys 
225                 230                 235                 240 


Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly Val Asp Val Ile Val Leu 
                245                 250                 255     


Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln Ile Ala Met Val His Tyr 
            260                 265                 270         


Ile Lys Gln Lys Tyr Pro His Leu Gln Val Ile Gly Gly Asn Val Val 
        275                 280                 285             


Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp Gly Leu 
    290                 295                 300                 


Arg Val Gly Met Gly Cys Gly Ser Ile Cys Ile Thr Gln Glu Val Met 
305                 310                 315                 320 


Ala Cys Gly Arg Pro Gln Gly Thr Ala Val Tyr Lys Val Ala Glu Tyr 
                325                 330                 335     


Ala Arg Arg Phe Gly Val Pro Ile Ile Ala Asp Gly Gly Ile Gln Thr 
            340                 345                 350         


Val Gly His Val Val Lys Ala Leu Ala Leu Gly Ala Ser Thr Val Met 
        355                 360                 365             


Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr Phe 
    370                 375                 380                 


Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser Leu 
385                 390                 395                 400 


Asp Ala Met Glu Lys Ser Ser Ser Ser Gln Lys Arg Tyr Phe Ser Glu 
                405                 410                 415     


Gly Asp Lys Val Lys Ile Ala Gln Gly Val Ser Gly Ser Ile Gln Asp 
            420                 425                 430         


Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile Gln 
        435                 440                 445             


His Gly Cys Gln Asp Ile Gly Ala Arg Ser Leu Ser Val Leu Arg Ser 
    450                 455                 460                 


Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Met Ser Ala 
465                 470                 475                 480 


Gln Ile Glu Gly Gly Val His Gly Leu His Ser Tyr Glu Lys Arg Leu 
                485                 490                 495     


Tyr 
    


<210>  81
<211>  380
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INOSINE MONOPHOSPHATE DEHYDROGENASE 1 (IMPDH1),
 ISOFORM CRA_C <Accession No.: EAW83651.1>

<400>  81

Met Arg His Gly Phe Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met 
1               5                   10                  15      


Gly Ser Lys Leu Val Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu 
            20                  25                  30          


Ala Glu Lys Asp His Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg 
        35                  40                  45              


Ile Glu Leu Val Val Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn 
    50                  55                  60                  


Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp 
65                  70                  75                  80  


Cys Asp Glu Leu Val Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn 
                85                  90                  95      


Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys 
            100                 105                 110         


Gly Ala Ala Val Gly Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu 
        115                 120                 125             


Leu Thr Gln Ala Gly Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly 
    130                 135                 140                 


Asn Ser Val Tyr Gln Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr 
145                 150                 155                 160 


Pro His Leu Gln Val Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala 
                165                 170                 175     


Lys Asn Leu Ile Asp Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly 
            180                 185                 190         


Cys Gly Ser Ile Cys Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro 
        195                 200                 205             


Gln Gly Thr Ala Val Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly 
    210                 215                 220                 


Val Pro Ile Ile Ala Asp Gly Gly Ile Gln Thr Val Gly His Val Val 
225                 230                 235                 240 


Lys Ala Leu Ala Leu Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu 
                245                 250                 255     


Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val 
            260                 265                 270         


Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys 
        275                 280                 285             


Ser Ser Ser Ser Gln Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys 
    290                 295                 300                 


Ile Ala Gln Gly Val Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln 
305                 310                 315                 320 


Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp 
                325                 330                 335     


Ile Gly Ala Arg Ser Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly 
            340                 345                 350         


Glu Leu Lys Phe Glu Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly 
        355                 360                 365             


Val His Gly Leu His Ser Tyr Glu Lys Arg Leu Tyr 
    370                 375                 380 


<210>  82
<211>  522
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INOSINE MONOPHOSPHATE DEHYDROGENASE 1 (IMPDH1), 
ISOFORM CRA_D <Accession No.: EAW83652.1>

<400>  82

Met Asp Arg Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly 
1               5                   10                  15      


Gly Thr Gly Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe 
            20                  25                  30          


Ala Ser Ala Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly 
        35                  40                  45              


Phe Ile Asp Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr 
    50                  55                  60                  


Arg Lys Ile Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr 
65                  70                  75                  80  


Val Thr Glu Ala Asp Met Ala Ile Ala Met Ala Leu Met Gly Gly Ile 
                85                  90                  95      


Gly Phe Ile His His Asn Cys Thr Pro Glu Phe Gln Ala Asn Glu Val 
            100                 105                 110         


Arg Lys Val Lys Lys Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val 
        115                 120                 125             


Leu Ser Pro Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg 
    130                 135                 140                 


His Gly Phe Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser 
145                 150                 155                 160 


Lys Leu Val Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala Glu 
                165                 170                 175     


Lys Asp His Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg Ile Glu 
            180                 185                 190         


Leu Val Val Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn Glu Ile 
        195                 200                 205             


Leu Gln Arg Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp Cys Asp 
    210                 215                 220                 


Glu Leu Val Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn Arg Asp 
225                 230                 235                 240 


Tyr Pro Leu Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala 
                245                 250                 255     


Ala Val Gly Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr 
            260                 265                 270         


Gln Ala Gly Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser 
        275                 280                 285             


Val Tyr Gln Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro His 
    290                 295                 300                 


Leu Gln Val Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala Lys Asn 
305                 310                 315                 320 


Leu Ile Asp Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly Cys Gly 
                325                 330                 335     


Ser Ile Cys Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro Gln Gly 
            340                 345                 350         


Thr Ala Val Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro 
        355                 360                 365             


Ile Ile Ala Asp Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala 
    370                 375                 380                 


Leu Ala Leu Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala 
385                 390                 395                 400 


Thr Thr Glu Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu 
                405                 410                 415     


Lys Lys Tyr Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys Ser Ser 
            420                 425                 430         


Ser Ser Gln Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys Ile Ala 
        435                 440                 445             


Gln Gly Val Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln Lys Phe 
    450                 455                 460                 


Val Pro Tyr Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp Ile Gly 
465                 470                 475                 480 


Ala Arg Ser Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu 
                485                 490                 495     


Lys Phe Glu Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His 
            500                 505                 510         


Gly Leu His Ser Tyr Glu Lys Arg Leu Tyr 
        515                 520         


<210>  83
<211>  195
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINAL DEGENERATION 3, GUCY2D REGULATOR (RD3) 
 <Accession No.: NP_001158160.1>

<400>  83

Met Ser Leu Ile Ser Trp Leu Arg Trp Asn Glu Ala Pro Ser Arg Leu 
1               5                   10                  15      


Ser Thr Arg Ser Pro Ala Glu Met Val Leu Glu Thr Leu Met Met Glu 
            20                  25                  30          


Leu Thr Gly Gln Met Arg Glu Ala Glu Arg Gln Gln Arg Glu Arg Ser 
        35                  40                  45              


Asn Ala Val Arg Lys Val Cys Thr Gly Val Asp Tyr Ser Trp Leu Ala 
    50                  55                  60                  


Ser Thr Pro Arg Ser Thr Tyr Asp Leu Ser Pro Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Cys Val Lys Ile His Pro Ser Tyr Cys Gly Pro Ala 
                85                  90                  95      


Ile Leu Arg Phe Arg Gln Leu Leu Ala Glu Gln Glu Pro Glu Val Gln 
            100                 105                 110         


Glu Val Ser Gln Leu Phe Arg Ser Val Leu Gln Glu Val Leu Glu Arg 
        115                 120                 125             


Met Lys Gln Glu Glu Glu Ala His Lys Leu Thr Arg Gln Trp Ser Leu 
    130                 135                 140                 


Arg Pro Arg Gly Ser Leu Ala Thr Phe Lys Thr Arg Ala Arg Ile Ser 
145                 150                 155                 160 


Pro Phe Ala Ser Asp Ile Arg Thr Ile Ser Glu Asp Val Glu Arg Asp 
                165                 170                 175     


Thr Pro Pro Pro Leu Arg Ser Trp Ser Met Pro Glu Phe Arg Ala Pro 
            180                 185                 190         


Lys Ala Asp 
        195 


<210>  84
<211>  316
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOL DEHYDROGENASE 12 (RDH12) <Accession No.: Q96NR8.3>

<400>  84

Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe Ser Phe Leu Tyr 
1               5                   10                  15      


Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly Gly Val Cys Arg 
            20                  25                  30          


Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile Thr Gly Ala Asn 
        35                  40                  45              


Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 
65                  70                  75                  80  


Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 
                85                  90                  95      


Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly Phe 
            100                 105                 110         


Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn Ala Gly Val 
        115                 120                 125             


Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Thr His Leu 
    130                 135                 140                 


Gly Val Asn His Leu Gly His Phe Leu Leu Thr Tyr Leu Leu Leu Glu 
145                 150                 155                 160 


Arg Leu Lys Val Ser Ala Pro Ala Arg Val Val Asn Val Ser Ser Val 
                165                 170                 175     


Ala His His Ile Gly Lys Ile Pro Phe His Asp Leu Gln Ser Glu Lys 
            180                 185                 190         


Arg Tyr Ser Arg Gly Phe Ala Tyr Cys His Ser Lys Leu Ala Asn Val 
        195                 200                 205             


Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly Thr Gly Val Thr 
    210                 215                 220                 


Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu Leu Val Arg His 
225                 230                 235                 240 


Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser Pro Phe Val Lys 
                245                 250                 255     


Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu His Cys Ala Leu Ala Glu 
            260                 265                 270         


Gly Leu Glu Pro Leu Ser Gly Lys Tyr Phe Ser Asp Cys Lys Arg Thr 
        275                 280                 285             


Trp Val Ser Pro Arg Ala Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp 
    290                 295                 300                 


Asn Val Ser Cys Glu Leu Leu Gly Ile Arg Trp Glu 
305                 310                 315     


<210>  85
<211>  316
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOL DEHYDROGENASE 12 (RDH12), ISOFORM 1, 
PARTIAL <Accession No.: ALQ34323.1>

<400>  85

Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe Ser Phe Leu Tyr 
1               5                   10                  15      


Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly Gly Val Cys Arg 
            20                  25                  30          


Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile Thr Gly Ala Asn 
        35                  40                  45              


Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 
65                  70                  75                  80  


Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 
                85                  90                  95      


Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly Phe 
            100                 105                 110         


Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn Ala Gly Val 
        115                 120                 125             


Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Thr His Leu 
    130                 135                 140                 


Gly Val Asn His Leu Gly His Phe Leu Leu Thr Tyr Leu Leu Leu Glu 
145                 150                 155                 160 


Arg Leu Lys Val Ser Ala Pro Ala Arg Val Val Asn Val Ser Ser Val 
                165                 170                 175     


Ala His His Ile Gly Lys Ile Pro Phe His Asp Leu Gln Ser Glu Lys 
            180                 185                 190         


Arg Tyr Ser Arg Gly Phe Ala Tyr Cys His Ser Lys Leu Ala Asn Val 
        195                 200                 205             


Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly Thr Gly Val Thr 
    210                 215                 220                 


Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu Leu Val Arg His 
225                 230                 235                 240 


Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser Pro Phe Val Lys 
                245                 250                 255     


Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu His Cys Ala Leu Ala Glu 
            260                 265                 270         


Gly Leu Glu Pro Leu Ser Gly Lys Tyr Phe Ser Asp Cys Lys Arg Thr 
        275                 280                 285             


Trp Val Ser Pro Arg Ala Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp 
    290                 295                 300                 


Asn Val Ser Cys Glu Leu Leu Gly Ile Arg Trp Glu 
305                 310                 315     


<210>  86
<211>  246
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOL DEHYDROGENASE 12 (RDH12), ISOFORM 4, 
PARTIAL <Accession No.: ALQ34324.1>

<400>  86

Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe Ser Phe Leu Tyr 
1               5                   10                  15      


Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly Gly Val Cys Arg 
            20                  25                  30          


Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile Thr Gly Ala Asn 
        35                  40                  45              


Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 
65                  70                  75                  80  


Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 
                85                  90                  95      


Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly Phe 
            100                 105                 110         


Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn Ala Gly Val 
        115                 120                 125             


Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Thr His Leu 
    130                 135                 140                 


Gly Val Asn His Leu Gly Thr Gly Val Thr Thr Tyr Ala Val His Pro 
145                 150                 155                 160 


Gly Val Val Arg Ser Glu Leu Val Arg His Ser Ser Leu Leu Cys Leu 
                165                 170                 175     


Leu Trp Arg Leu Phe Ser Pro Phe Val Lys Thr Ala Arg Glu Gly Ala 
            180                 185                 190         


Gln Thr Ser Leu His Cys Ala Leu Ala Glu Gly Leu Glu Pro Leu Ser 
        195                 200                 205             


Gly Lys Tyr Phe Ser Asp Cys Lys Arg Thr Trp Val Ser Pro Arg Ala 
    210                 215                 220                 


Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp Asn Val Ser Cys Glu Leu 
225                 230                 235                 240 


Leu Gly Ile Arg Trp Glu 
                245     


<210>  87
<211>  316
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOL DEHYDROGENASE 12 (RDH12), PRECURSOR 
<Accession No.: NP_689656.2>

<400>  87

Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe Ser Phe Leu Tyr 
1               5                   10                  15      


Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly Gly Val Cys Arg 
            20                  25                  30          


Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile Thr Gly Ala Asn 
        35                  40                  45              


Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 
65                  70                  75                  80  


Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 
                85                  90                  95      


Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly Phe 
            100                 105                 110         


Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn Ala Gly Val 
        115                 120                 125             


Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Thr His Leu 
    130                 135                 140                 


Gly Val Asn His Leu Gly His Phe Leu Leu Thr Tyr Leu Leu Leu Glu 
145                 150                 155                 160 


Arg Leu Lys Val Ser Ala Pro Ala Arg Val Val Asn Val Ser Ser Val 
                165                 170                 175     


Ala His His Ile Gly Lys Ile Pro Phe His Asp Leu Gln Ser Glu Lys 
            180                 185                 190         


Arg Tyr Ser Arg Gly Phe Ala Tyr Cys His Ser Lys Leu Ala Asn Val 
        195                 200                 205             


Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly Thr Gly Val Thr 
    210                 215                 220                 


Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu Leu Val Arg His 
225                 230                 235                 240 


Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser Pro Phe Val Lys 
                245                 250                 255     


Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu His Cys Ala Leu Ala Glu 
            260                 265                 270         


Gly Leu Glu Pro Leu Ser Gly Lys Tyr Phe Ser Asp Cys Lys Arg Thr 
        275                 280                 285             


Trp Val Ser Pro Arg Ala Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp 
    290                 295                 300                 


Asn Val Ser Cys Glu Leu Leu Gly Ile Arg Trp Glu 
305                 310                 315     


<210>  88
<211>  230
<212>  PRT
<213>  Homo sapiens

<220>
<223>  LECITHIN RETINOL ACYLTRANSFERASE (LRAT) <Accession 
No.: AAD13529.1>

<400>  88

Met Lys Asn Pro Met Leu Glu Val Val Ser Leu Leu Leu Glu Lys Leu 
1               5                   10                  15      


Leu Leu Ile Ser Asn Phe Thr Leu Phe Ser Ser Gly Ala Ala Gly Lys 
            20                  25                  30          


Asp Lys Gly Arg Asn Ser Phe Tyr Glu Thr Ser Ser Phe His Arg Gly 
        35                  40                  45              


Asp Val Leu Glu Val Pro Arg Thr His Leu Thr His Tyr Gly Ile Tyr 
    50                  55                  60                  


Leu Gly Asp Asn Arg Val Ala His Met Met Pro Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Leu Thr Asp Asp Met Gly Arg Thr Gln Lys Val Val Ser Asn Lys Arg 
                85                  90                  95      


Leu Ile Leu Gly Val Ile Val Lys Val Ala Ser Ile Arg Val Asp Thr 
            100                 105                 110         


Val Glu Asp Phe Ala Tyr Gly Ala Asn Ile Leu Val Asn His Leu Asp 
        115                 120                 125             


Glu Ser Leu Gln Lys Lys Ala Leu Leu Asn Glu Glu Val Ala Arg Arg 
    130                 135                 140                 


Ala Glu Lys Leu Leu Gly Phe Thr Pro Tyr Ser Leu Leu Trp Asn Asn 
145                 150                 155                 160 


Cys Glu His Phe Val Thr Tyr Cys Arg Tyr Gly Thr Pro Ile Ser Pro 
                165                 170                 175     


Gln Ser Asp Lys Phe Cys Glu Thr Val Lys Ile Ile Ile Arg Asp Gln 
            180                 185                 190         


Arg Ser Val Leu Ala Ser Ala Val Leu Gly Leu Ala Ser Ile Val Cys 
        195                 200                 205             


Thr Gly Leu Val Ser Tyr Thr Thr Leu Pro Ala Ile Phe Ile Pro Phe 
    210                 215                 220                 


Phe Leu Trp Met Ala Gly 
225                 230 


<210>  89
<211>  542
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TUBBY LIKE PROTEIN 1 (TULP1) <Accession No.: AAB97966.1>

<400>  89

Met Pro Leu Arg Asp Glu Thr Leu Arg Glu Val Trp Ala Ser Asp Ser 
1               5                   10                  15      


Gly His Glu Glu Glu Ser Leu Ser Pro Glu Ala Pro Arg Arg Pro Lys 
            20                  25                  30          


Gln Arg Pro Ala Pro Ala Gln Arg Leu Arg Lys Lys Arg Thr Glu Ala 
        35                  40                  45              


Pro Glu Ser Pro Cys Pro Thr Gly Ser Lys Pro Arg Lys Pro Gly Ala 
    50                  55                  60                  


Gly Arg Arg Gly Arg Pro Arg Glu Glu Pro Ser Pro Asp Pro Ala Gln 
65                  70                  75                  80  


Ala Arg Ala Pro Gln Thr Val Tyr Ala Arg Phe Leu Arg Asp Pro Glu 
                85                  90                  95      


Ala Lys Lys Arg Asp Pro Arg Glu Thr Phe Leu Val Ala Arg Ala Pro 
            100                 105                 110         


Asp Ala Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Ala Glu Glu Lys Lys Glu Lys Ile Leu Leu Pro Pro Lys 
    130                 135                 140                 


Lys Pro Leu Arg Glu Lys Ser Ser Ala Asp Leu Lys Glu Arg Arg Ala 
145                 150                 155                 160 


Lys Ala Gln Gly Pro Arg Gly Asp Leu Gly Ser Pro Asp Pro Pro Pro 
                165                 170                 175     


Lys Pro Leu Arg Val Arg Asn Lys Glu Ala Pro Ala Gly Glu Gly Thr 
            180                 185                 190         


Lys Met Arg Lys Thr Lys Lys Lys Gly Ser Gly Glu Ala Asp Lys Asp 
        195                 200                 205             


Pro Ser Gly Ser Pro Ala Ser Ala Arg Lys Ser Pro Ala Ala Met Phe 
    210                 215                 220                 


Leu Val Gly Glu Gly Ser Pro Asp Lys Lys Ala Leu Lys Lys Lys Gly 
225                 230                 235                 240 


Thr Pro Lys Gly Ala Arg Lys Glu Glu Glu Glu Glu Glu Glu Ala Ala 
                245                 250                 255     


Thr Val Ile Lys Asn Ser Asn Gln Lys Gly Lys Ala Lys Gly Lys Gly 
            260                 265                 270         


Lys Lys Lys Ala Lys Glu Glu Arg Ala Pro Ser Pro Pro Val Glu Val 
        275                 280                 285             


Asp Glu Pro Arg Glu Phe Val Leu Arg Pro Ala Pro Gln Gly Arg Thr 
    290                 295                 300                 


Val Arg Cys Arg Leu Thr Arg Asp Lys Lys Gly Met Asp Arg Gly Met 
305                 310                 315                 320 


Tyr Pro Ser Tyr Phe Leu His Leu Asp Thr Glu Lys Lys Val Phe Leu 
                325                 330                 335     


Leu Ala Gly Arg Lys Arg Lys Arg Ser Lys Thr Ala Asn Tyr Leu Ile 
            340                 345                 350         


Ser Ile Asp Pro Thr Asn Leu Ser Arg Gly Gly Glu Asn Phe Ile Gly 
        355                 360                 365             


Lys Leu Arg Ser Asn Leu Leu Gly Asn Arg Phe Thr Val Phe Asp Asn 
    370                 375                 380                 


Gly Gln Asn Pro Gln Arg Gly Tyr Ser Thr Asn Val Ala Ser Leu Arg 
385                 390                 395                 400 


Gln Glu Leu Ala Ala Val Ile Tyr Glu Thr Asn Val Leu Gly Phe Arg 
                405                 410                 415     


Gly Pro Arg Arg Met Thr Val Ile Ile Pro Gly Met Ser Ala Glu Asn 
            420                 425                 430         


Glu Arg Val Pro Ile Arg Pro Arg Asn Ala Ser Asp Gly Leu Leu Val 
        435                 440                 445             


Arg Trp Gln Asn Lys Thr Leu Glu Ser Leu Ile Glu Leu His Asn Lys 
    450                 455                 460                 


Pro Pro Val Trp Asn Asp Asp Ser Gly Ser Tyr Thr Leu Asn Phe Gln 
465                 470                 475                 480 


Gly Arg Val Thr Gln Ala Ser Val Lys Asn Phe Gln Ile Val His Ala 
                485                 490                 495     


Asp Asp Pro Asp Tyr Ile Val Leu Gln Phe Gly Arg Val Ala Glu Asp 
            500                 505                 510         


Ala Phe Thr Leu Asp Tyr Arg Tyr Pro Leu Cys Ala Leu Gln Ala Phe 
        515                 520                 525             


Ala Ile Ala Leu Ser Ser Phe Asp Gly Lys Leu Ala Cys Glu 
    530                 535                 540         


<210>  90
<211>  487
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TUBBY LIKE PROTEIN 1 (TULP1), ISOFORM CRA_A 
<Accession No.: EAX03839.1>

<400>  90

Met Pro Leu Arg Asp Glu Thr Leu Arg Glu Val Trp Ala Ser Asp Ser 
1               5                   10                  15      


Gly His Glu Glu Glu Ser Leu Ser Pro Glu Ala Pro Arg Arg Pro Lys 
            20                  25                  30          


Gln Arg Pro Ala Pro Ala Gln Arg Leu Arg Lys Lys Arg Thr Glu Ala 
        35                  40                  45              


Pro Glu Ser Pro Cys Pro Thr Gly Ser Lys Pro Arg Lys Pro Gly Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Ala Glu 
65                  70                  75                  80  


Glu Lys Lys Glu Lys Ile Leu Leu Pro Pro Lys Lys Pro Leu Arg Glu 
                85                  90                  95      


Lys Ser Ser Ala Asp Leu Lys Glu Arg Arg Ala Lys Ala Gln Gly Pro 
            100                 105                 110         


Arg Gly Asp Leu Gly Ser Pro Asp Pro Pro Pro Lys Pro Leu Arg Val 
        115                 120                 125             


Arg Asn Lys Glu Ala Pro Ala Gly Glu Gly Thr Lys Met Arg Lys Thr 
    130                 135                 140                 


Lys Lys Lys Gly Ser Gly Glu Ala Asp Lys Asp Pro Ser Gly Ser Pro 
145                 150                 155                 160 


Ala Ser Ala Arg Lys Ser Pro Ala Ala Met Phe Leu Val Gly Glu Gly 
                165                 170                 175     


Ser Pro Asp Lys Lys Ala Leu Lys Lys Lys Gly Thr Pro Lys Gly Ala 
            180                 185                 190         


Arg Lys Glu Glu Glu Glu Glu Glu Glu Ala Ala Thr Val Ile Lys Asn 
        195                 200                 205             


Ser Asn Gln Lys Gly Lys Ala Lys Gly Lys Gly Lys Lys Lys Glu Glu 
    210                 215                 220                 


Arg Ala Pro Ser Pro Pro Val Glu Val Asp Glu Pro Arg Glu Phe Val 
225                 230                 235                 240 


Leu Arg Pro Ala Pro Gln Gly Arg Thr Val Arg Cys Arg Leu Thr Arg 
                245                 250                 255     


Asp Lys Lys Gly Met Asp Arg Gly Met Tyr Pro Ser Tyr Phe Leu His 
            260                 265                 270         


Leu Asp Thr Glu Lys Lys Val Phe Leu Leu Ala Gly Arg Lys Arg Lys 
        275                 280                 285             


Arg Ser Lys Thr Ala Asn Tyr Leu Ile Ser Ile Asp Pro Thr Asn Leu 
    290                 295                 300                 


Ser Arg Gly Gly Glu Asn Phe Ile Gly Lys Leu Arg Ser Asn Leu Leu 
305                 310                 315                 320 


Gly Asn Arg Phe Thr Val Phe Asp Asn Gly Gln Asn Pro Gln Arg Gly 
                325                 330                 335     


Tyr Ser Thr Asn Val Ala Ser Leu Arg Gln Glu Leu Ala Ala Val Ile 
            340                 345                 350         


Tyr Glu Thr Asn Val Leu Gly Phe Arg Gly Pro Arg Arg Met Thr Val 
        355                 360                 365             


Ile Ile Pro Gly Met Ser Ala Glu Asn Glu Arg Val Pro Ile Arg Pro 
    370                 375                 380                 


Arg Asn Ala Ser Asp Gly Leu Leu Val Arg Trp Gln Asn Lys Thr Leu 
385                 390                 395                 400 


Glu Ser Leu Ile Glu Leu His Asn Lys Pro Pro Val Trp Asn Asp Asp 
                405                 410                 415     


Ser Gly Ser Tyr Thr Leu Asn Phe Gln Gly Arg Val Thr Gln Ala Ser 
            420                 425                 430         


Val Lys Asn Phe Gln Ile Val His Ala Asp Asp Pro Asp Tyr Ile Val 
        435                 440                 445             


Leu Gln Phe Gly Arg Val Ala Glu Asp Ala Phe Thr Leu Asp Tyr Arg 
    450                 455                 460                 


Tyr Pro Leu Cys Ala Leu Gln Ala Phe Ala Ile Ala Leu Ser Ser Phe 
465                 470                 475                 480 


Asp Gly Lys Leu Ala Cys Glu 
                485         


<210>  91
<211>  540
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TUBBY LIKE PROTEIN 1 (TULP1), ISOFORM CRA_B 
<Accession No.: EAX03840.1>

<400>  91

Met Pro Leu Arg Asp Glu Thr Leu Arg Glu Val Trp Ala Ser Asp Ser 
1               5                   10                  15      


Gly His Glu Glu Glu Ser Leu Ser Pro Glu Ala Pro Arg Arg Pro Lys 
            20                  25                  30          


Gln Arg Pro Ala Pro Ala Gln Arg Leu Arg Lys Lys Arg Thr Glu Ala 
        35                  40                  45              


Pro Glu Ser Pro Cys Pro Thr Gly Ser Lys Pro Arg Lys Pro Gly Ala 
    50                  55                  60                  


Gly Arg Arg Gly Arg Pro Arg Glu Glu Pro Ser Pro Asp Pro Ala Gln 
65                  70                  75                  80  


Ala Arg Ala Pro Gln Thr Val Tyr Ala Arg Phe Leu Arg Asp Pro Glu 
                85                  90                  95      


Ala Lys Lys Arg Asp Pro Arg Glu Thr Phe Leu Val Ala Arg Ala Pro 
            100                 105                 110         


Asp Ala Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Ala Glu Glu Lys Lys Glu Lys Ile Leu Leu Pro Pro Lys 
    130                 135                 140                 


Lys Pro Leu Arg Glu Lys Ser Ser Ala Asp Leu Lys Glu Arg Arg Ala 
145                 150                 155                 160 


Lys Ala Gln Gly Pro Arg Gly Asp Leu Gly Ser Pro Asp Pro Pro Pro 
                165                 170                 175     


Lys Pro Leu Arg Val Arg Asn Lys Glu Ala Pro Ala Gly Glu Gly Thr 
            180                 185                 190         


Lys Met Arg Lys Thr Lys Lys Lys Gly Ser Gly Glu Ala Asp Lys Asp 
        195                 200                 205             


Pro Ser Gly Ser Pro Ala Ser Ala Arg Lys Ser Pro Ala Ala Met Phe 
    210                 215                 220                 


Leu Val Gly Glu Gly Ser Pro Asp Lys Lys Ala Leu Lys Lys Lys Gly 
225                 230                 235                 240 


Thr Pro Lys Gly Ala Arg Lys Glu Glu Glu Glu Glu Glu Glu Ala Ala 
                245                 250                 255     


Thr Val Ile Lys Asn Ser Asn Gln Lys Gly Lys Ala Lys Gly Lys Gly 
            260                 265                 270         


Lys Lys Lys Glu Glu Arg Ala Pro Ser Pro Pro Val Glu Val Asp Glu 
        275                 280                 285             


Pro Arg Glu Phe Val Leu Arg Pro Ala Pro Gln Gly Arg Thr Val Arg 
    290                 295                 300                 


Cys Arg Leu Thr Arg Asp Lys Lys Gly Met Asp Arg Gly Met Tyr Pro 
305                 310                 315                 320 


Ser Tyr Phe Leu His Leu Asp Thr Glu Lys Lys Val Phe Leu Leu Ala 
                325                 330                 335     


Gly Arg Lys Arg Lys Arg Ser Lys Thr Ala Asn Tyr Leu Ile Ser Ile 
            340                 345                 350         


Asp Pro Thr Asn Leu Ser Arg Gly Gly Glu Asn Phe Ile Gly Lys Leu 
        355                 360                 365             


Arg Ser Asn Leu Leu Gly Asn Arg Phe Thr Val Phe Asp Asn Gly Gln 
    370                 375                 380                 


Asn Pro Gln Arg Gly Tyr Ser Thr Asn Val Ala Ser Leu Arg Gln Glu 
385                 390                 395                 400 


Leu Ala Ala Val Ile Tyr Glu Thr Asn Val Leu Gly Phe Arg Gly Pro 
                405                 410                 415     


Arg Arg Met Thr Val Ile Ile Pro Gly Met Ser Ala Glu Asn Glu Arg 
            420                 425                 430         


Val Pro Ile Arg Pro Arg Asn Ala Ser Asp Gly Leu Leu Val Arg Trp 
        435                 440                 445             


Gln Asn Lys Thr Leu Glu Ser Leu Ile Glu Leu His Asn Lys Pro Pro 
    450                 455                 460                 


Val Trp Asn Asp Asp Ser Gly Ser Tyr Thr Leu Asn Phe Gln Gly Arg 
465                 470                 475                 480 


Val Thr Gln Ala Ser Val Lys Asn Phe Gln Ile Val His Ala Asp Asp 
                485                 490                 495     


Pro Asp Tyr Ile Val Leu Gln Phe Gly Arg Val Ala Glu Asp Ala Phe 
            500                 505                 510         


Thr Leu Asp Tyr Arg Tyr Pro Leu Cys Ala Leu Gln Ala Phe Ala Ile 
        515                 520                 525             


Ala Leu Ser Ser Phe Asp Gly Lys Leu Ala Cys Glu 
    530                 535                 540 


<210>  92
<211>  561
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TUBBY LIKE PROTEIN 1 (TULP1), HOMOLOG ISOFORM A 
<Accession No.: NP_003311.2>

<400>  92

Met Gly Ala Arg Thr Pro Leu Pro Ser Phe Trp Val Ser Phe Phe Ala 
1               5                   10                  15      


Glu Thr Gly Ile Leu Phe Pro Gly Gly Thr Pro Trp Pro Met Gly Ser 
            20                  25                  30          


Gln His Ser Lys Gln His Arg Lys Pro Gly Pro Leu Lys Arg Gly His 
        35                  40                  45              


Arg Arg Asp Arg Arg Thr Thr Arg Arg Lys Tyr Trp Lys Glu Gly Arg 
    50                  55                  60                  


Glu Ile Ala Arg Val Leu Asp Asp Glu Gly Arg Asn Leu Arg Gln Gln 
65                  70                  75                  80  


Lys Leu Asp Arg Gln Arg Ala Leu Leu Glu Gln Lys Gln Lys Lys Lys 
                85                  90                  95      


Arg Gln Glu Pro Leu Met Val Gln Ala Asn Ala Asp Gly Arg Pro Arg 
            100                 105                 110         


Ser Arg Arg Ala Arg Gln Ser Glu Glu Gln Ala Pro Leu Val Glu Ser 
        115                 120                 125             


Tyr Leu Ser Ser Ser Gly Ser Thr Ser Tyr Gln Val Gln Glu Ala Asp 
    130                 135                 140                 


Ser Leu Ala Ser Val Gln Leu Gly Ala Thr Arg Pro Thr Ala Pro Ala 
145                 150                 155                 160 


Ser Ala Lys Arg Thr Lys Ala Ala Ala Thr Ala Gly Gly Gln Gly Gly 
                165                 170                 175     


Ala Ala Arg Lys Glu Lys Lys Gly Lys His Lys Gly Thr Ser Gly Pro 
            180                 185                 190         


Ala Ala Leu Ala Glu Asp Lys Ser Glu Ala Gln Gly Pro Val Gln Ile 
        195                 200                 205             


Leu Thr Val Gly Gln Ser Asp His Ala Gln Asp Ala Gly Glu Thr Ala 
    210                 215                 220                 


Ala Gly Gly Gly Glu Arg Pro Ser Gly Gln Asp Leu Arg Ala Thr Met 
225                 230                 235                 240 


Gln Arg Lys Gly Ile Ser Ser Ser Met Ser Phe Asp Glu Asp Glu Glu 
                245                 250                 255     


Asp Glu Glu Glu Asn Ser Ser Ser Ser Ser Gln Leu Asn Ser Asn Thr 
            260                 265                 270         


Arg Pro Ser Ser Ala Thr Ser Arg Lys Ser Val Arg Glu Ala Ala Ser 
        275                 280                 285             


Ala Pro Ser Pro Thr Ala Pro Glu Gln Pro Val Asp Val Glu Val Gln 
    290                 295                 300                 


Asp Leu Glu Glu Phe Ala Leu Arg Pro Ala Pro Gln Gly Ile Thr Ile 
305                 310                 315                 320 


Lys Cys Arg Ile Thr Arg Asp Lys Lys Gly Met Asp Arg Gly Met Tyr 
                325                 330                 335     


Pro Thr Tyr Phe Leu His Leu Asp Arg Glu Asp Gly Lys Lys Val Phe 
            340                 345                 350         


Leu Leu Ala Gly Arg Lys Arg Lys Lys Ser Lys Thr Ser Asn Tyr Leu 
        355                 360                 365             


Ile Ser Val Asp Pro Thr Asp Leu Ser Arg Gly Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Gly Lys Leu Arg Ser Asn Leu Met Gly Thr Lys Phe Thr Val Tyr Asp 
385                 390                 395                 400 


Asn Gly Val Asn Pro Gln Lys Ala Ser Ser Ser Thr Leu Glu Ser Gly 
                405                 410                 415     


Thr Leu Arg Gln Glu Leu Ala Ala Val Cys Tyr Glu Thr Asn Val Leu 
            420                 425                 430         


Gly Phe Lys Gly Pro Arg Lys Met Ser Val Ile Val Pro Gly Met Asn 
        435                 440                 445             


Met Val His Glu Arg Val Ser Ile Arg Pro Arg Asn Glu His Glu Thr 
    450                 455                 460                 


Leu Leu Ala Arg Trp Gln Asn Lys Asn Thr Glu Ser Ile Ile Glu Leu 
465                 470                 475                 480 


Gln Asn Lys Thr Pro Val Trp Asn Asp Asp Thr Gln Ser Tyr Val Leu 
                485                 490                 495     


Asn Phe His Gly Arg Val Thr Gln Ala Ser Val Lys Asn Phe Gln Ile 
            500                 505                 510         


Ile His Gly Asn Asp Pro Asp Tyr Ile Val Met Gln Phe Gly Arg Val 
        515                 520                 525             


Ala Glu Asp Val Phe Thr Met Asp Tyr Asn Tyr Pro Leu Cys Ala Leu 
    530                 535                 540                 


Gln Ala Phe Ala Ile Ala Leu Ser Ser Phe Asp Ser Lys Leu Ala Cys 
545                 550                 555                 560 


Glu 
    


<210>  93
<211>  506
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TUBBY LIKE PROTEIN 1 (TULP1) <Accession No.: NP_813977.1>

<400>  93

Met Thr Ser Lys Pro His Ser Asp Trp Ile Pro Tyr Ser Val Leu Asp 
1               5                   10                  15      


Asp Glu Gly Arg Asn Leu Arg Gln Gln Lys Leu Asp Arg Gln Arg Ala 
            20                  25                  30          


Leu Leu Glu Gln Lys Gln Lys Lys Lys Arg Gln Glu Pro Leu Met Val 
        35                  40                  45              


Gln Ala Asn Ala Asp Gly Arg Pro Arg Ser Arg Arg Ala Arg Gln Ser 
    50                  55                  60                  


Glu Glu Gln Ala Pro Leu Val Glu Ser Tyr Leu Ser Ser Ser Gly Ser 
65                  70                  75                  80  


Thr Ser Tyr Gln Val Gln Glu Ala Asp Ser Leu Ala Ser Val Gln Leu 
                85                  90                  95      


Gly Ala Thr Arg Pro Thr Ala Pro Ala Ser Ala Lys Arg Thr Lys Ala 
            100                 105                 110         


Ala Ala Thr Ala Gly Gly Gln Gly Gly Ala Ala Arg Lys Glu Lys Lys 
        115                 120                 125             


Gly Lys His Lys Gly Thr Ser Gly Pro Ala Ala Leu Ala Glu Asp Lys 
    130                 135                 140                 


Ser Glu Ala Gln Gly Pro Val Gln Ile Leu Thr Val Gly Gln Ser Asp 
145                 150                 155                 160 


His Ala Gln Asp Ala Gly Glu Thr Ala Ala Gly Gly Gly Glu Arg Pro 
                165                 170                 175     


Ser Gly Gln Asp Leu Arg Ala Thr Met Gln Arg Lys Gly Ile Ser Ser 
            180                 185                 190         


Ser Met Ser Phe Asp Glu Asp Glu Glu Asp Glu Glu Glu Asn Ser Ser 
        195                 200                 205             


Ser Ser Ser Gln Leu Asn Ser Asn Thr Arg Pro Ser Ser Ala Thr Ser 
    210                 215                 220                 


Arg Lys Ser Val Arg Glu Ala Ala Ser Ala Pro Ser Pro Thr Ala Pro 
225                 230                 235                 240 


Glu Gln Pro Val Asp Val Glu Val Gln Asp Leu Glu Glu Phe Ala Leu 
                245                 250                 255     


Arg Pro Ala Pro Gln Gly Ile Thr Ile Lys Cys Arg Ile Thr Arg Asp 
            260                 265                 270         


Lys Lys Gly Met Asp Arg Gly Met Tyr Pro Thr Tyr Phe Leu His Leu 
        275                 280                 285             


Asp Arg Glu Asp Gly Lys Lys Val Phe Leu Leu Ala Gly Arg Lys Arg 
    290                 295                 300                 


Lys Lys Ser Lys Thr Ser Asn Tyr Leu Ile Ser Val Asp Pro Thr Asp 
305                 310                 315                 320 


Leu Ser Arg Gly Gly Asp Ser Tyr Ile Gly Lys Leu Arg Ser Asn Leu 
                325                 330                 335     


Met Gly Thr Lys Phe Thr Val Tyr Asp Asn Gly Val Asn Pro Gln Lys 
            340                 345                 350         


Ala Ser Ser Ser Thr Leu Glu Ser Gly Thr Leu Arg Gln Glu Leu Ala 
        355                 360                 365             


Ala Val Cys Tyr Glu Thr Asn Val Leu Gly Phe Lys Gly Pro Arg Lys 
    370                 375                 380                 


Met Ser Val Ile Val Pro Gly Met Asn Met Val His Glu Arg Val Ser 
385                 390                 395                 400 


Ile Arg Pro Arg Asn Glu His Glu Thr Leu Leu Ala Arg Trp Gln Asn 
                405                 410                 415     


Lys Asn Thr Glu Ser Ile Ile Glu Leu Gln Asn Lys Thr Pro Val Trp 
            420                 425                 430         


Asn Asp Asp Thr Gln Ser Tyr Val Leu Asn Phe His Gly Arg Val Thr 
        435                 440                 445             


Gln Ala Ser Val Lys Asn Phe Gln Ile Ile His Gly Asn Asp Pro Asp 
    450                 455                 460                 


Tyr Ile Val Met Gln Phe Gly Arg Val Ala Glu Asp Val Phe Thr Met 
465                 470                 475                 480 


Asp Tyr Asn Tyr Pro Leu Cys Ala Leu Gln Ala Phe Ala Ile Ala Leu 
                485                 490                 495     


Ser Ser Phe Asp Ser Lys Leu Ala Cys Glu 
            500                 505     


<210>  94
<211>  360
<212>  PRT
<213>  Homo sapiens

<220>
<223>  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 13 
(KCNJ13) <Accession No.: O60928.1>

<400>  94

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Thr Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Pro Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Gly Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  95
<211>  360
<212>  PRT
<213>  Homo sapiens

<220>
<223>  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 
13 (KCNJ13) <Accession No.: AAH37290.1>

<400>  95

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Tyr Val Leu Ala Glu 
65                  70                  75                  80  


Met Asn Gly Asp Leu Glu Leu Asp His Asp Ala Pro Pro Glu Asn His 
                85                  90                  95      


Thr Ile Cys Val Lys Tyr Ile Thr Ser Phe Thr Ala Ala Phe Ser Phe 
            100                 105                 110         


Ser Leu Glu Thr Gln Leu Thr Ile Gly Tyr Gly Thr Met Phe Pro Ser 
        115                 120                 125             


Gly Asp Cys Pro Ser Ala Ile Ala Leu Leu Ala Ile Gln Met Leu Leu 
    130                 135                 140                 


Gly Leu Met Leu Glu Ala Phe Ile Thr Gly Ala Phe Val Ala Lys Ile 
145                 150                 155                 160 


Ala Arg Pro Lys Asn Arg Ala Phe Ser Ile Arg Phe Thr Asp Ile Ala 
                165                 170                 175     


Val Val Ala His Met Asp Gly Lys Pro Asn Leu Ile Phe Gln Val Ala 
            180                 185                 190         


Asn Thr Arg Pro Ser Pro Leu Thr Ser Val Arg Val Ser Ala Val Leu 
        195                 200                 205             


Tyr Gln Glu Arg Glu Asn Gly Lys Leu Tyr Gln Thr Ser Val Asp Phe 
    210                 215                 220                 


His Leu Asp Gly Ile Ser Ser Asp Glu Cys Pro Phe Phe Ile Phe Pro 
225                 230                 235                 240 


Leu Thr Tyr Tyr His Ser Ile Thr Pro Ser Ser Pro Leu Ala Thr Leu 
                245                 250                 255     


Leu Gln His Glu Asn Pro Ser His Phe Glu Leu Val Val Phe Leu Ser 
            260                 265                 270         


Ala Met Gln Glu Gly Thr Gly Glu Ile Cys Gln Arg Arg Thr Ser Tyr 
        275                 280                 285             


Leu Gln Ser Glu Ile Met Leu His His Cys Phe Ala Ser Leu Leu Thr 
    290                 295                 300                 


Arg Gly Ser Lys Cys Glu Tyr Gln Ile Lys Met Glu Asn Phe Asp Lys 
305                 310                 315                 320 


Thr Val Pro Glu Phe Pro Thr Pro Leu Val Ser Lys Ser Pro Asn Arg 
                325                 330                 335     


Thr Asp Leu Asp Ile His Ile Asn Gly Gln Ser Ile Asp Asn Phe Gln 
            340                 345                 350         


Ile Ser Glu Thr Gly Leu Thr Glu 
        355                 360 


<210>  96
<211>  318
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MITOCHONDRIALLY ENCODED NADH DEHYDROGENASE 1 (MT-ND1) 
<Accession No.: P03886.1>

<400>  96

Met Pro Met Ala Asn Leu Leu Leu Leu Ile Val Pro Ile Leu Ile Ala 
1               5                   10                  15      


Met Ala Phe Leu Met Leu Thr Glu Arg Lys Ile Leu Gly Tyr Met Gln 
            20                  25                  30          


Leu Arg Lys Gly Pro Asn Val Val Gly Pro Tyr Gly Leu Leu Gln Pro 
        35                  40                  45              


Phe Ala Asp Ala Met Lys Leu Phe Thr Lys Glu Pro Leu Lys Pro Ala 
    50                  55                  60                  


Thr Ser Thr Ile Thr Leu Tyr Ile Thr Ala Pro Thr Leu Ala Leu Thr 
65                  70                  75                  80  


Ile Ala Leu Leu Leu Trp Thr Pro Leu Pro Met Pro Asn Pro Leu Val 
                85                  90                  95      


Asn Leu Asn Leu Gly Leu Leu Phe Ile Leu Ala Thr Ser Ser Leu Ala 
            100                 105                 110         


Val Tyr Ser Ile Leu Trp Ser Gly Trp Ala Ser Asn Ser Asn Tyr Ala 
        115                 120                 125             


Leu Ile Gly Ala Leu Arg Ala Val Ala Gln Thr Ile Ser Tyr Glu Val 
    130                 135                 140                 


Thr Leu Ala Ile Ile Leu Leu Ser Thr Leu Leu Met Ser Gly Ser Phe 
145                 150                 155                 160 


Asn Leu Ser Thr Leu Ile Thr Thr Gln Glu His Leu Trp Leu Leu Leu 
                165                 170                 175     


Pro Ser Trp Pro Leu Ala Met Met Trp Phe Ile Ser Thr Leu Ala Glu 
            180                 185                 190         


Thr Asn Arg Thr Pro Phe Asp Leu Ala Glu Gly Glu Ser Glu Leu Val 
        195                 200                 205             


Ser Gly Phe Asn Ile Glu Tyr Ala Ala Gly Pro Phe Ala Leu Phe Phe 
    210                 215                 220                 


Met Ala Glu Tyr Thr Asn Ile Ile Met Met Asn Thr Leu Thr Thr Thr 
225                 230                 235                 240 


Ile Phe Leu Gly Thr Thr Tyr Asp Ala Leu Ser Pro Glu Leu Tyr Thr 
                245                 250                 255     


Thr Tyr Phe Val Thr Lys Thr Leu Leu Leu Thr Ser Leu Phe Leu Trp 
            260                 265                 270         


Ile Arg Thr Ala Tyr Pro Arg Phe Arg Tyr Asp Gln Leu Met His Leu 
        275                 280                 285             


Leu Trp Lys Asn Phe Leu Pro Leu Thr Leu Ala Leu Leu Met Trp Tyr 
    290                 295                 300                 


Val Ser Met Pro Ile Thr Ile Ser Ser Ile Pro Pro Gln Thr 
305                 310                 315             


<210>  97
<211>  459
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MITOCHONDRIALLY ENCODED NADH DEHYDROGENASE 4 (MT-ND4) 
<Accession No.: ACT53103.1>

<400>  97

Met Leu Lys Leu Ile Val Pro Thr Ile Met Leu Leu Pro Leu Thr Trp 
1               5                   10                  15      


Leu Ser Lys Lys His Met Ile Trp Ile Asn Thr Thr Thr His Ser Leu 
            20                  25                  30          


Ile Ile Ser Ile Ile Pro Leu Leu Phe Phe Asn Gln Ile Asn Asn Asn 
        35                  40                  45              


Leu Phe Ser Cys Ser Pro Thr Phe Ser Ser Asp Pro Leu Thr Thr Pro 
    50                  55                  60                  


Leu Leu Met Leu Thr Thr Trp Leu Leu Pro Leu Thr Ile Met Ala Ser 
65                  70                  75                  80  


Gln Arg His Leu Ser Ser Glu Pro Leu Ser Arg Lys Lys Leu Tyr Leu 
                85                  90                  95      


Ser Met Leu Ile Ser Leu Gln Ile Ser Leu Ile Met Thr Phe Thr Ala 
            100                 105                 110         


Thr Glu Leu Ile Met Phe Tyr Ile Phe Phe Glu Thr Thr Leu Ile Pro 
        115                 120                 125             


Thr Leu Ala Ile Ile Thr Arg Trp Gly Asn Gln Pro Glu Arg Leu Asn 
    130                 135                 140                 


Ala Gly Thr Tyr Phe Leu Phe Tyr Thr Leu Val Gly Ser Leu Pro Leu 
145                 150                 155                 160 


Leu Ile Ala Leu Ile Tyr Thr His Asn Thr Leu Gly Ser Leu Asn Ile 
                165                 170                 175     


Leu Leu Leu Thr Leu Thr Ala Gln Glu Leu Ser Asn Ser Trp Ala Asn 
            180                 185                 190         


Asn Leu Met Trp Leu Ala Tyr Thr Met Ala Phe Met Val Lys Met Pro 
        195                 200                 205             


Leu Tyr Gly Leu His Leu Trp Leu Pro Lys Ala His Val Glu Ala Pro 
    210                 215                 220                 


Ile Ala Gly Ser Met Val Leu Ala Ala Val Leu Leu Lys Leu Gly Gly 
225                 230                 235                 240 


Tyr Gly Met Met Arg Leu Thr Leu Ile Leu Asn Pro Leu Thr Lys His 
                245                 250                 255     


Met Ala Tyr Pro Phe Leu Val Leu Ser Leu Trp Gly Met Ile Met Thr 
            260                 265                 270         


Ser Ser Ile Cys Leu Arg Gln Thr Asp Leu Lys Ser Leu Ile Ala Tyr 
        275                 280                 285             


Ser Ser Ile Ser His Met Ala Leu Val Val Thr Ala Ile Leu Ile Gln 
    290                 295                 300                 


Thr Pro Trp Ser Phe Thr Gly Ala Val Ile Leu Met Ile Ala His Gly 
305                 310                 315                 320 


Leu Thr Ser Ser Leu Leu Phe Cys Leu Ala Asn Ser Asn Tyr Glu Arg 
                325                 330                 335     


Thr His Ser Arg Ile Met Ile Leu Ser Gln Gly Leu Gln Thr Leu Leu 
            340                 345                 350         


Pro Leu Met Ala Phe Trp Trp Leu Leu Ala Ser Leu Ala Asn Leu Ala 
        355                 360                 365             


Leu Pro Pro Thr Ile Asn Leu Leu Gly Glu Leu Ser Val Leu Val Thr 
    370                 375                 380                 


Thr Phe Ser Trp Ser Asn Ile Thr Leu Leu Leu Thr Gly Leu Asn Met 
385                 390                 395                 400 


Leu Val Thr Ala Leu Tyr Ser Leu Tyr Met Phe Thr Thr Thr Gln Trp 
                405                 410                 415     


Gly Ser Leu Thr His His Ile Asn Asn Met Lys Pro Ser Phe Thr Arg 
            420                 425                 430         


Glu Asn Thr Leu Met Phe Met His Leu Ser Pro Ile Leu Leu Leu Ser 
        435                 440                 445             


Leu Asn Pro Asp Ile Ile Thr Gly Phe Ser Ser 
    450                 455                 


<210>  98
<211>  174
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MITOCHONDRIALLY ENCODED NADH DEHYDROGENASE 6 (MT-ND6)
 <Accession No.: ACT53105.1>

<400>  98

Met Met Tyr Ala Leu Phe Leu Leu Ser Val Gly Leu Val Met Gly Phe 
1               5                   10                  15      


Val Gly Phe Ser Ser Lys Pro Ser Pro Ile Tyr Gly Gly Leu Val Leu 
            20                  25                  30          


Ile Val Ser Gly Val Val Gly Cys Val Ile Ile Leu Asn Phe Gly Gly 
        35                  40                  45              


Gly Tyr Met Gly Leu Met Val Phe Leu Ile Tyr Leu Gly Gly Met Met 
    50                  55                  60                  


Val Val Phe Gly Tyr Thr Thr Ala Met Ala Ile Glu Glu Tyr Pro Glu 
65                  70                  75                  80  


Ala Trp Gly Ser Gly Val Glu Val Leu Val Ser Val Leu Val Gly Leu 
                85                  90                  95      


Ala Met Glu Val Gly Leu Val Leu Trp Val Lys Glu Tyr Asp Gly Val 
            100                 105                 110         


Val Val Val Val Asn Phe Asn Ser Val Gly Ser Trp Met Ile Tyr Glu 
        115                 120                 125             


Gly Glu Gly Ser Gly Leu Ile Arg Glu Asp Pro Ile Gly Ala Gly Ala 
    130                 135                 140                 


Leu Tyr Asp Tyr Gly Arg Trp Leu Val Val Val Thr Gly Trp Thr Leu 
145                 150                 155                 160 


Phe Val Gly Val Tyr Ile Val Ile Glu Ile Ala Arg Gly Asn 
                165                 170                 


<210>  99
<211>  1306
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ANGIOTENSIN I CONVERTING ENZYME (ACE) <Accession No.: P12821.1>

<400>  99

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Ala Arg Ser 
    1220                 1225                 1230             


Glu Gly  Pro Leu Pro Asp Ser  Gly Arg Val Ser Phe  Leu Gly Leu 
    1235                 1240                 1245             


Asp Leu  Asp Ala Gln Gln Ala  Arg Val Gly Gln Trp  Leu Leu Leu 
    1250                 1255                 1260             


Phe Leu  Gly Ile Ala Leu Leu  Val Ala Thr Leu Gly  Leu Ser Gln 
    1265                 1270                 1275             


Arg Leu  Phe Ser Ile Arg His  Arg Ser Leu His Arg  His Ser His 
    1280                 1285                 1290             


Gly Pro  Gln Phe Gly Ser Glu  Val Glu Leu Arg His  Ser 
    1295                 1300                 1305     


<210>  100
<211>  1306
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ANGIOTENSIN I CONVERTING ENZYME (ACE), ISOFORM 1 PRECURSOR 
<Accession No.: NP_000780.1>

<400>  100

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Ala Arg Ser 
    1220                 1225                 1230             


Glu Gly  Pro Leu Pro Asp Ser  Gly Arg Val Ser Phe  Leu Gly Leu 
    1235                 1240                 1245             


Asp Leu  Asp Ala Gln Gln Ala  Arg Val Gly Gln Trp  Leu Leu Leu 
    1250                 1255                 1260             


Phe Leu  Gly Ile Ala Leu Leu  Val Ala Thr Leu Gly  Leu Ser Gln 
    1265                 1270                 1275             


Arg Leu  Phe Ser Ile Arg His  Arg Ser Leu His Arg  His Ser His 
    1280                 1285                 1290             


Gly Pro  Gln Phe Gly Ser Glu  Val Glu Leu Arg His  Ser 
    1295                 1300                 1305     


<210>  101
<211>  732
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ANGIOTENSIN I CONVERTING ENZYME (ACE), ISOFORM 2 
PRECURSOR <Accession No.: NP_690043.1>

<400>  101

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp 
        195                 200                 205             


Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile 
    210                 215                 220                 


Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg 
225                 230                 235                 240 


Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu 
                245                 250                 255     


Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln 
            260                 265                 270         


Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg 
        275                 280                 285             


His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His 
    290                 295                 300                 


Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu 
305                 310                 315                 320 


Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met 
                325                 330                 335     


Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp 
            340                 345                 350         


Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn 
        355                 360                 365             


Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His 
    370                 375                 380                 


Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln 
385                 390                 395                 400 


Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met 
                405                 410                 415     


Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu 
            420                 425                 430         


Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu 
        435                 440                 445             


Ala Leu Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu 
    450                 455                 460                 


Ser Ser Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys 
465                 470                 475                 480 


Met Ala Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp 
                485                 490                 495     


Gln Trp Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr 
            500                 505                 510         


Asn Gln Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro 
        515                 520                 525             


Pro Val Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His 
    530                 535                 540                 


Ile Pro Ser Ser Val Pro Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile 
545                 550                 555                 560 


Gln Phe Gln Phe His Glu Ala Leu Cys Gln Ala Ala Gly His Thr Gly 
                565                 570                 575     


Pro Leu His Lys Cys Asp Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg 
            580                 585                 590         


Leu Ala Thr Ala Met Lys Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala 
        595                 600                 605             


Met Gln Leu Ile Thr Gly Gln Pro Asn Met Ser Ala Ser Ala Met Leu 
    610                 615                 620                 


Ser Tyr Phe Lys Pro Leu Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu 
625                 630                 635                 640 


His Gly Glu Lys Leu Gly Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser 
                645                 650                 655     


Ala Arg Ser Glu Gly Pro Leu Pro Asp Ser Gly Arg Val Ser Phe Leu 
            660                 665                 670         


Gly Leu Asp Leu Asp Ala Gln Gln Ala Arg Val Gly Gln Trp Leu Leu 
        675                 680                 685             


Leu Phe Leu Gly Ile Ala Leu Leu Val Ala Thr Leu Gly Leu Ser Gln 
    690                 695                 700                 


Arg Leu Phe Ser Ile Arg His Arg Ser Leu His Arg His Ser His Gly 
705                 710                 715                 720 


Pro Gln Phe Gly Ser Glu Val Glu Leu Arg His Ser 
                725                 730         


<210>  102
<211>  178
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTERLEUKIN 10 (IL10) <Accession No.: CAG46790.1>

<400>  102

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  103
<211>  653
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RAB ESCORT PROTEIN 1 (CHM) <Accession No.: EAW98559.1>

<400>  103

Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210>  104
<211>  224
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOSCHISIN (RS1) <Accession No.: NP_000321.1>

<400>  104

Met Ser Arg Lys Ile Glu Gly Phe Leu Leu Leu Leu Leu Phe Gly Tyr 
1               5                   10                  15      


Glu Ala Thr Leu Gly Leu Ser Ser Thr Glu Asp Glu Gly Glu Asp Pro 
            20                  25                  30          


Trp Tyr Gln Lys Ala Cys Lys Cys Asp Cys Gln Gly Gly Pro Asn Ala 
        35                  40                  45              


Leu Trp Ser Ala Gly Ala Thr Ser Leu Asp Cys Ile Pro Glu Cys Pro 
    50                  55                  60                  


Tyr His Lys Pro Leu Gly Phe Glu Ser Gly Glu Val Thr Pro Asp Gln 
65                  70                  75                  80  


Ile Thr Cys Ser Asn Pro Glu Gln Tyr Val Gly Trp Tyr Ser Ser Trp 
                85                  90                  95      


Thr Ala Asn Lys Ala Arg Leu Asn Ser Gln Gly Phe Gly Cys Ala Trp 
            100                 105                 110         


Leu Ser Lys Phe Gln Asp Ser Ser Gln Trp Leu Gln Ile Asp Leu Lys 
        115                 120                 125             


Glu Ile Lys Val Ile Ser Gly Ile Leu Thr Gln Gly Arg Cys Asp Ile 
    130                 135                 140                 


Asp Glu Trp Met Thr Lys Tyr Ser Val Gln Tyr Arg Thr Asp Glu Arg 
145                 150                 155                 160 


Leu Asn Trp Ile Tyr Tyr Lys Asp Gln Thr Gly Asn Asn Arg Val Phe 
                165                 170                 175     


Tyr Gly Asn Ser Asp Arg Thr Ser Thr Val Gln Asn Leu Leu Arg Pro 
            180                 185                 190         


Pro Ile Ile Ser Arg Phe Ile Arg Leu Ile Pro Leu Gly Trp His Val 
        195                 200                 205             


Arg Ile Ala Ile Arg Met Glu Leu Leu Glu Cys Val Ser Lys Cys Ala 
    210                 215                 220                 


<210>  105
<211>  50
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOSCHISIN (RS1), PARTIAL <Accession No.: ABK40506.1>

<400>  105

Val Phe Tyr Gly Asn Ser Asp Arg Thr Ser Thr Val Gln Asn Leu Leu 
1               5                   10                  15      


Arg Pro Pro Ile Ile Ser Arg Phe Ile Arg Leu Ile Pro Leu Gly Cys 
            20                  25                  30          


His Val Arg Ile Ala Ile Arg Met Glu Leu Leu Glu Cys Val Ser Lys 
        35                  40                  45              


Cys Ala 
    50  


<210>  106
<211>  593
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 1 (BBS1) <Accession No.: AAM92770.1>

<400>  106

Met Ala Ala Ala Ser Ser Ser Asp Ser Asp Ala Cys Gly Ala Glu Ser 
1               5                   10                  15      


Asn Glu Ala Asn Ser Lys Trp Leu Asp Ala His Tyr Asp Pro Met Ala 
            20                  25                  30          


Asn Ile His Thr Phe Ser Ala Cys Leu Ala Leu Ala Asp Leu His Gly 
        35                  40                  45              


Asp Gly Glu Tyr Lys Leu Val Val Gly Asp Leu Gly Pro Gly Gly Gln 
    50                  55                  60                  


Gln Pro Arg Leu Lys Val Leu Lys Gly Pro Leu Val Met Thr Glu Ser 
65                  70                  75                  80  


Pro Leu Pro Ala Leu Pro Ala Ala Ala Ala Thr Phe Leu Met Glu Gln 
                85                  90                  95      


His Glu Pro Arg Thr Pro Ala Leu Ala Leu Ala Ser Gly Pro Cys Val 
            100                 105                 110         


Tyr Val Tyr Lys Asn Leu Arg Pro Tyr Phe Lys Phe Ser Leu Pro Gln 
        115                 120                 125             


Leu Pro Pro Asn Pro Leu Glu Gln Asp Leu Trp Asn Gln Ala Lys Glu 
    130                 135                 140                 


Asp Arg Ile Asp Pro Leu Thr Leu Lys Glu Met Leu Glu Ser Ile Arg 
145                 150                 155                 160 


Glu Thr Ala Glu Glu Pro Leu Ser Ile Gln Ser Leu Arg Phe Leu Gln 
                165                 170                 175     


Leu Glu Leu Ser Glu Met Glu Ala Phe Val Asn Gln His Lys Ser Asn 
            180                 185                 190         


Ser Ile Lys Arg Gln Thr Val Ile Thr Thr Met Thr Thr Leu Lys Lys 
        195                 200                 205             


Asn Leu Ala Asp Glu Asp Ala Val Ser Cys Leu Val Leu Gly Thr Glu 
    210                 215                 220                 


Asn Lys Glu Leu Leu Val Leu Asp Pro Glu Ala Phe Thr Ile Leu Ala 
225                 230                 235                 240 


Lys Met Ser Leu Pro Ser Val Pro Val Phe Leu Glu Val Ser Gly Gln 
                245                 250                 255     


Phe Asp Val Glu Phe Arg Leu Ala Ala Ala Cys Arg Asn Gly Asn Ile 
            260                 265                 270         


Tyr Ile Leu Arg Arg Asp Ser Lys His Pro Lys Tyr Cys Ile Glu Leu 
        275                 280                 285             


Ser Ala Gln Pro Val Gly Leu Ile Arg Val His Lys Val Leu Val Val 
    290                 295                 300                 


Gly Ser Thr Gln Asp Ser Leu His Gly Phe Thr His Lys Gly Lys Lys 
305                 310                 315                 320 


Leu Trp Thr Val Gln Met Pro Ala Ala Ile Leu Thr Met Asn Leu Leu 
                325                 330                 335     


Glu Gln His Ser Arg Gly Leu Gln Ala Val Met Ala Gly Leu Ala Asn 
            340                 345                 350         


Gly Glu Val Arg Ile Tyr Arg Asp Lys Ala Leu Leu Asn Val Ile His 
        355                 360                 365             


Thr Pro Asp Ala Val Thr Ser Leu Cys Phe Gly Arg Tyr Gly Arg Glu 
    370                 375                 380                 


Asp Asn Thr Leu Ile Met Thr Thr Arg Gly Gly Gly Leu Ile Ile Lys 
385                 390                 395                 400 


Ile Leu Lys Arg Thr Ala Val Phe Val Glu Gly Gly Ser Glu Val Gly 
                405                 410                 415     


Pro Pro Pro Ala Gln Ala Met Lys Leu Asn Val Pro Arg Lys Thr Arg 
            420                 425                 430         


Leu Tyr Val Asp Gln Thr Leu Arg Glu Arg Glu Ala Gly Thr Ala Met 
        435                 440                 445             


His Arg Ala Phe Gln Thr Asp Leu Tyr Leu Leu Arg Leu Arg Ala Ala 
    450                 455                 460                 


Arg Ala Tyr Leu Gln Ala Leu Glu Ser Ser Leu Ser Pro Leu Ser Thr 
465                 470                 475                 480 


Thr Ala Arg Glu Pro Leu Lys Leu His Ala Val Val Gln Gly Leu Gly 
                485                 490                 495     


Pro Thr Phe Lys Leu Thr Leu His Leu Gln Asn Thr Ser Thr Thr Arg 
            500                 505                 510         


Pro Val Leu Gly Leu Leu Val Cys Phe Leu Tyr Asn Glu Ala Leu Tyr 
        515                 520                 525             


Ser Leu Pro Arg Ala Phe Phe Lys Val Pro Leu Leu Val Pro Gly Leu 
    530                 535                 540                 


Asn Tyr Pro Leu Glu Thr Phe Val Glu Ser Leu Ser Asn Lys Gly Ile 
545                 550                 555                 560 


Ser Asp Ile Ile Lys Val Leu Val Leu Arg Glu Gly Gln Ser Ala Pro 
                565                 570                 575     


Leu Leu Ser Ala His Val Asn Met Pro Gly Ser Glu Gly Leu Ala Ala 
            580                 585                 590         


Ala 
    


<210>  107
<211>  721
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 2 (BBS2) <Accession No.: AAH14140.1>

<400>  107

Met Leu Leu Pro Val Phe Thr Leu Lys Leu Arg His Lys Ile Ser Pro 
1               5                   10                  15      


Arg Met Val Ala Ile Gly Arg Tyr Asp Gly Thr His Pro Cys Leu Ala 
            20                  25                  30          


Ala Ala Thr Gln Thr Gly Lys Val Phe Ile His Asn Pro His Thr Arg 
        35                  40                  45              


Asn Gln His Val Ser Ala Ser Arg Val Phe Gln Ser Pro Leu Glu Ser 
    50                  55                  60                  


Asp Val Ser Leu Leu Asn Ile Asn Gln Ala Val Ser Cys Leu Thr Ala 
65                  70                  75                  80  


Gly Val Leu Asn Pro Glu Leu Gly Tyr Asp Ala Leu Leu Val Gly Thr 
                85                  90                  95      


Gln Thr Asn Leu Leu Ala Tyr Asp Val Tyr Asn Asn Ser Asp Leu Phe 
            100                 105                 110         


Tyr Arg Glu Val Ala Asp Gly Ala Asn Val Val Val Leu Gly Thr Leu 
        115                 120                 125             


Gly Asp Ile Ser Ser Pro Leu Ala Ile Ile Gly Gly Asn Cys Ala Leu 
    130                 135                 140                 


Gln Gly Phe Asn His Glu Gly Ser Asp Leu Phe Trp Thr Val Thr Gly 
145                 150                 155                 160 


Asp Asn Val Asn Ser Leu Ala Leu Cys Asp Phe Asp Gly Asp Gly Lys 
                165                 170                 175     


Lys Glu Leu Leu Val Gly Ser Glu Asp Phe Asp Ile Arg Val Phe Lys 
            180                 185                 190         


Glu Asp Glu Ile Val Ala Glu Met Thr Glu Thr Glu Ile Val Thr Ser 
        195                 200                 205             


Leu Cys Pro Met Tyr Gly Ser Arg Phe Gly Tyr Ala Leu Ser Asn Gly 
    210                 215                 220                 


Thr Val Gly Val Tyr Asp Lys Thr Ser Arg Tyr Trp Arg Ile Lys Ser 
225                 230                 235                 240 


Lys Asn His Ala Met Ser Ile His Ala Phe Asp Leu Asn Ser Asp Gly 
                245                 250                 255     


Val Asn Glu Leu Ile Thr Gly Trp Ser Asn Gly Lys Val Asp Ala Arg 
            260                 265                 270         


Ser Asp Arg Thr Gly Glu Val Ile Phe Lys Asp Asn Phe Ser Ser Ala 
        275                 280                 285             


Ile Ala Gly Val Val Glu Gly Asp Tyr Arg Met Asp Gly His Ile Gln 
    290                 295                 300                 


Leu Ile Cys Cys Ser Val Asp Gly Glu Ile Arg Gly Tyr Leu Pro Gly 
305                 310                 315                 320 


Thr Ala Glu Met Arg Gly Asn Leu Met Asp Thr Ser Ala Glu Gln Asp 
                325                 330                 335     


Leu Ile Arg Glu Leu Ser Gln Lys Lys Gln Asn Leu Leu Leu Glu Leu 
            340                 345                 350         


Arg Asn Tyr Glu Glu Asn Ala Lys Ala Glu Leu Ala Ser Pro Leu Asn 
        355                 360                 365             


Glu Ala Asp Gly His Arg Gly Ile Ile Pro Ala Asn Thr Arg Leu His 
    370                 375                 380                 


Thr Thr Leu Ser Val Ser Leu Gly Asn Glu Thr Gln Thr Ala His Thr 
385                 390                 395                 400 


Glu Leu Arg Ile Ser Thr Ser Asn Asp Thr Ile Ile Arg Ala Val Leu 
                405                 410                 415     


Ile Phe Ala Glu Gly Ile Phe Thr Gly Glu Ser His Val Val His Pro 
            420                 425                 430         


Ser Ile His Asn Leu Ser Ser Ser Ile Cys Ile Pro Ile Val Pro Pro 
        435                 440                 445             


Lys Asp Val Pro Val Asp Leu His Leu Lys Ala Phe Val Gly Tyr Arg 
    450                 455                 460                 


Ser Ser Thr Gln Phe His Val Phe Glu Ser Thr Arg Gln Leu Pro Arg 
465                 470                 475                 480 


Phe Ser Met Tyr Ala Leu Thr Ser Leu Asp Pro Ala Ser Glu Pro Ile 
                485                 490                 495     


Ser Tyr Val Asn Phe Thr Ile Ala Glu Arg Ala Gln Arg Val Val Val 
            500                 505                 510         


Trp Leu Gly Gln Asn Phe Leu Leu Pro Glu Asp Thr His Ile Gln Asn 
        515                 520                 525             


Ala Pro Phe Gln Val Cys Phe Thr Ser Leu Arg Asn Gly Gly His Leu 
    530                 535                 540                 


His Ile Lys Ile Lys Leu Ser Gly Glu Ile Thr Ile Asn Thr Asp Asp 
545                 550                 555                 560 


Ile Asp Leu Ala Gly Asp Ile Ile Gln Ser Met Ala Ser Phe Phe Ala 
                565                 570                 575     


Ile Glu Asp Leu Gln Val Glu Ala Asp Phe Pro Val Tyr Phe Glu Glu 
            580                 585                 590         


Leu Arg Lys Val Leu Val Lys Val Asp Glu Tyr His Ser Val His Gln 
        595                 600                 605             


Lys Leu Ser Ala Asp Met Ala Asp His Ser Asn Leu Ile Arg Ser Leu 
    610                 615                 620                 


Leu Val Gly Ala Glu Asp Ala Arg Leu Met Arg Asp Met Lys Thr Met 
625                 630                 635                 640 


Lys Ser Arg Tyr Met Glu Leu Tyr Asp Leu Asn Arg Asp Leu Leu Asn 
                645                 650                 655     


Gly Tyr Lys Ile Arg Cys Asn Asn His Thr Glu Leu Leu Gly Asn Leu 
            660                 665                 670         


Lys Ala Val Asn Gln Ala Ile Gln Arg Ala Gly Arg Leu Arg Val Gly 
        675                 680                 685             


Lys Pro Lys Asn Gln Val Ile Thr Ala Cys Arg Asp Ala Ile Arg Ser 
    690                 695                 700                 


Asn Asn Ile Asn Thr Leu Phe Lys Ile Met Arg Val Gly Thr Ala Ser 
705                 710                 715                 720 


Ser 
    


<210>  108
<211>  193
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ADP RIBOSYLATION FACTOR LIKE GTPASE 6 (ARL6), ISOFORM 
BB3SL <Accession No.: NP_001310442.1>

<400>  108

Met Gly Leu Leu Asp Arg Leu Ser Val Leu Leu Gly Leu Lys Lys Lys 
1               5                   10                  15      


Glu Val His Val Leu Cys Leu Gly Leu Asp Asn Ser Gly Lys Thr Thr 
            20                  25                  30          


Ile Ile Asn Lys Leu Lys Pro Ser Asn Ala Gln Ser Gln Asn Ile Leu 
        35                  40                  45              


Pro Thr Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser Leu Ser 
    50                  55                  60                  


Phe Thr Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn Leu Trp 
65                  70                  75                  80  


Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile Asp Ser 
                85                  90                  95      


Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp Thr Leu 
            100                 105                 110         


Leu Asn His Pro Asp Ile Lys His Arg Arg Ile Pro Ile Leu Phe Phe 
        115                 120                 125             


Ala Asn Lys Met Asp Leu Arg Asp Ala Val Thr Ser Val Lys Val Ser 
    130                 135                 140                 


Gln Leu Leu Cys Leu Glu Asn Ile Lys Asp Lys Pro Trp His Ile Cys 
145                 150                 155                 160 


Ala Ser Asp Ala Ile Lys Gly Glu Gly Leu Gln Glu Gly Val Asp Trp 
                165                 170                 175     


Leu Gln Glu Lys Thr Ile Gln Ser Asp Pro Asp Cys Glu Asp Met Lys 
            180                 185                 190         


Arg 
    


<210>  109
<211>  186
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ADP RIBOSYLATION FACTOR LIKE GTPASE 6 (ARL6), 
ISOFORM 1 <Accession No.: NP_001265222.1>

<400>  109

Met Gly Leu Leu Asp Arg Leu Ser Val Leu Leu Gly Leu Lys Lys Lys 
1               5                   10                  15      


Glu Val His Val Leu Cys Leu Gly Leu Asp Asn Ser Gly Lys Thr Thr 
            20                  25                  30          


Ile Ile Asn Lys Leu Lys Pro Ser Asn Ala Gln Ser Gln Asn Ile Leu 
        35                  40                  45              


Pro Thr Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser Leu Ser 
    50                  55                  60                  


Phe Thr Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn Leu Trp 
65                  70                  75                  80  


Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile Asp Ser 
                85                  90                  95      


Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp Thr Leu 
            100                 105                 110         


Leu Asn His Pro Asp Ile Lys His Arg Arg Ile Pro Ile Leu Phe Phe 
        115                 120                 125             


Ala Asn Lys Met Asp Leu Arg Asp Ala Val Thr Ser Val Lys Val Ser 
    130                 135                 140                 


Gln Leu Leu Cys Leu Glu Asn Ile Lys Asp Lys Pro Trp His Ile Cys 
145                 150                 155                 160 


Ala Ser Asp Ala Ile Lys Gly Glu Gly Leu Gln Glu Gly Val Asp Trp 
                165                 170                 175     


Leu Gln Asp Gln Ile Gln Thr Val Lys Thr 
            180                 185     


<210>  110
<211>  159
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ADP RIBOSYLATION FACTOR LIKE GTPASE 6 (ARL6), ISOFORM 2 
<Accession No.: NP_001310443.1>

<400>  110

Met Gly Leu Leu Asp Arg Leu Ser Val Leu Leu Gly Leu Lys Lys Lys 
1               5                   10                  15      


Glu Val His Val Leu Cys Leu Gly Leu Asp Asn Ser Gly Lys Thr Thr 
            20                  25                  30          


Ile Ile Asn Lys Leu Lys Pro Ser Asn Ala Gln Ser Gln Asn Ile Leu 
        35                  40                  45              


Pro Thr Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser Leu Ser 
    50                  55                  60                  


Phe Thr Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn Leu Trp 
65                  70                  75                  80  


Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile Asp Ser 
                85                  90                  95      


Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp Thr Leu 
            100                 105                 110         


Leu Asn His Pro Asp Ile Lys His Arg Arg Ile Pro Ile Leu Phe Phe 
        115                 120                 125             


Ala Asn Lys Met Asp Leu Arg Asp Ala Val Thr Ser Val Lys Val Ser 
    130                 135                 140                 


Gln Leu Leu Cys Leu Glu Asn Ile Lys Asp Lys Pro Trp His Ile 
145                 150                 155                 


<210>  111
<211>  519
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 4 (BBS4) <Accession No.: AAH27624.1>

<400>  111

Met Ala Glu Glu Arg Val Ala Thr Arg Thr Gln Phe Pro Val Ser Thr 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Thr Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Thr Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Thr Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu Leu Thr Thr Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys Ala Phe Glu His 
    210                 215                 220                 


Leu Gly Asn Ala Leu Thr Tyr Asp Pro Thr Asn Tyr Lys Ala Ile Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Met Met Gln Thr His Gly Asp Phe Asp Val Ala Leu 
                245                 250                 255     


Thr Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu Ser Pro Pro Leu 
            260                 265                 270         


Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys Lys Tyr Val Ala 
        275                 280                 285             


Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala Pro Phe Asp Trp 
    290                 295                 300                 


Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Thr Met Gln Gln Tyr 
305                 310                 315                 320 


Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn Phe Gln Pro Lys 
                325                 330                 335     


Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu Thr Asn Leu Glu 
            340                 345                 350         


Asp Thr Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His Leu Asp 
        355                 360                 365             


Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu Tyr Asn 
    370                 375                 380                 


Gln Gly Glu Lys Lys Asn Ala Leu Val Gln Tyr Gln Glu Met Glu Lys 
385                 390                 395                 400 


Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp Ser Glu 
                405                 410                 415     


Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val Gly Glu 
            420                 425                 430         


Ala Leu Val Trp Thr Lys Pro Val Lys Asp Pro Lys Ser Lys His Gln 
        435                 440                 445             


Thr Thr Ser Thr Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu Gly Ser 
    450                 455                 460                 


Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr Arg Thr 
465                 470                 475                 480 


Leu Pro Ser Gly Ala Gly Gly Thr Ser Gln Phe Thr Lys Pro Pro Ser 
                485                 490                 495     


Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser Pro Thr Glu Thr 
            500                 505                 510         


Ser Glu Gln Ile Arg Glu Lys 
        515                 


<210>  112
<211>  519
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 4 (BBS4), ISOFORM 1 
<Accession No.: NP_149017.2>

<400>  112

Met Ala Glu Glu Arg Val Ala Thr Arg Thr Gln Phe Pro Val Ser Thr 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Thr Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Thr Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Thr Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu Leu Thr Thr Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys Ala Phe Glu His 
    210                 215                 220                 


Leu Gly Asn Ala Leu Thr Tyr Asp Pro Thr Asn Tyr Lys Ala Ile Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Met Met Gln Thr His Gly Asp Phe Asp Val Ala Leu 
                245                 250                 255     


Thr Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu Ser Pro Pro Leu 
            260                 265                 270         


Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys Lys Tyr Val Ala 
        275                 280                 285             


Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala Pro Phe Asp Trp 
    290                 295                 300                 


Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Thr Met Gln Gln Tyr 
305                 310                 315                 320 


Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn Phe Gln Pro Lys 
                325                 330                 335     


Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu Thr Asn Leu Glu 
            340                 345                 350         


Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His Leu Asp 
        355                 360                 365             


Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu Tyr Asn 
    370                 375                 380                 


Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln Glu Met Glu Lys 
385                 390                 395                 400 


Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp Ser Glu 
                405                 410                 415     


Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val Gly Glu 
            420                 425                 430         


Ala Leu Val Trp Thr Lys Pro Val Lys Asp Pro Lys Ser Lys His Gln 
        435                 440                 445             


Thr Thr Ser Thr Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu Gly Ser 
    450                 455                 460                 


Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr Arg Thr 
465                 470                 475                 480 


Leu Pro Ser Gly Ala Gly Gly Thr Ser Gln Phe Thr Lys Pro Pro Ser 
                485                 490                 495     


Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser Pro Thr Glu Thr 
            500                 505                 510         


Ser Glu Gln Ile Arg Glu Lys 
        515                 


<210>  113
<211>  347
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 4 (BBS4), ISOFORM 2 <Accession No.:
 NP_001239607.1>

<400>  113

Met Leu Gly Lys Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile 
1               5                   10                  15      


Glu Val Tyr Lys Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu 
            20                  25                  30          


Leu Thr Thr Leu Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys 
        35                  40                  45              


Ala Phe Glu His Leu Gly Asn Ala Leu Thr Tyr Asp Pro Thr Asn Tyr 
    50                  55                  60                  


Lys Ala Ile Leu Ala Ala Gly Ser Met Met Gln Thr His Gly Asp Phe 
65                  70                  75                  80  


Asp Val Ala Leu Thr Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu 
                85                  90                  95      


Ser Pro Pro Leu Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys 
            100                 105                 110         


Lys Tyr Val Ala Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala 
        115                 120                 125             


Pro Phe Asp Trp Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Thr 
    130                 135                 140                 


Met Gln Gln Tyr Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn 
145                 150                 155                 160 


Phe Gln Pro Lys Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu 
                165                 170                 175     


Thr Asn Leu Glu Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala 
            180                 185                 190         


Val His Leu Asp Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val 
        195                 200                 205             


Leu Leu Tyr Asn Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln 
    210                 215                 220                 


Glu Met Glu Lys Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu 
225                 230                 235                 240 


Phe Asp Ser Glu Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu 
                245                 250                 255     


Gln Val Gly Glu Ala Leu Val Trp Thr Lys Pro Val Lys Asp Pro Lys 
            260                 265                 270         


Ser Lys His Gln Thr Thr Ser Thr Ser Lys Pro Ala Ser Phe Gln Gln 
        275                 280                 285             


Pro Leu Gly Ser Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala 
    290                 295                 300                 


Ala Tyr Arg Thr Leu Pro Ser Gly Ala Gly Gly Thr Ser Gln Phe Thr 
305                 310                 315                 320 


Lys Pro Pro Ser Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser 
                325                 330                 335     


Pro Thr Glu Thr Ser Glu Gln Ile Arg Glu Lys 
            340                 345         


<210>  114
<211>  496
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 4 (BBS4), ISOFORM 3 <Accession 
No.: NP_001307594.1>

<400>  114

Met Ala Glu Glu Arg Val Ala Thr Arg Thr Gln Phe Pro Val Ser Thr 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Thr Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Thr Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Thr Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu Leu Thr Thr Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Ala Ile Leu Ala Ala Gly Ser Met Met Gln 
    210                 215                 220                 


Thr His Gly Asp Phe Asp Val Ala Leu Thr Lys Tyr Arg Val Val Ala 
225                 230                 235                 240 


Cys Ala Val Pro Glu Ser Pro Pro Leu Trp Asn Asn Ile Gly Met Cys 
                245                 250                 255     


Phe Phe Gly Lys Lys Lys Tyr Val Ala Ala Ile Ser Cys Leu Lys Arg 
            260                 265                 270         


Ala Asn Tyr Leu Ala Pro Phe Asp Trp Lys Ile Leu Tyr Asn Leu Gly 
        275                 280                 285             


Leu Val His Leu Thr Met Gln Gln Tyr Ala Ser Ala Phe His Phe Leu 
    290                 295                 300                 


Ser Ala Ala Ile Asn Phe Gln Pro Lys Met Gly Glu Leu Tyr Met Leu 
305                 310                 315                 320 


Leu Ala Val Ala Leu Thr Asn Leu Glu Asp Ile Glu Asn Ala Lys Arg 
                325                 330                 335     


Ala Tyr Ala Glu Ala Val His Leu Asp Lys Cys Asn Pro Leu Val Asn 
            340                 345                 350         


Leu Asn Tyr Ala Val Leu Leu Tyr Asn Gln Gly Glu Lys Lys Asn Ala 
        355                 360                 365             


Leu Ala Gln Tyr Gln Glu Met Glu Lys Lys Val Ser Leu Leu Lys Asp 
    370                 375                 380                 


Asn Ser Ser Leu Glu Phe Asp Ser Glu Met Val Glu Met Ala Gln Lys 
385                 390                 395                 400 


Leu Gly Ala Ala Leu Gln Val Gly Glu Ala Leu Val Trp Thr Lys Pro 
                405                 410                 415     


Val Lys Asp Pro Lys Ser Lys His Gln Thr Thr Ser Thr Ser Lys Pro 
            420                 425                 430         


Ala Ser Phe Gln Gln Pro Leu Gly Ser Asn Gln Ala Leu Gly Gln Ala 
        435                 440                 445             


Met Ser Ser Ala Ala Ala Tyr Arg Thr Leu Pro Ser Gly Ala Gly Gly 
    450                 455                 460                 


Thr Ser Gln Phe Thr Lys Pro Pro Ser Leu Pro Leu Glu Pro Glu Pro 
465                 470                 475                 480 


Ala Val Glu Ser Ser Pro Thr Glu Thr Ser Glu Gln Ile Arg Glu Lys 
                485                 490                 495     


<210>  115
<211>  341
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 5 (BBS5) <Accession No.: NP_689597.1>

<400>  115

Met Ser Val Leu Asp Ala Leu Trp Glu Asp Arg Asp Val Arg Phe Asp 
1               5                   10                  15      


Leu Ser Ala Gln Gln Met Lys Thr Arg Pro Gly Glu Val Leu Ile Asp 
            20                  25                  30          


Cys Leu Asp Ser Ile Glu Asp Thr Lys Gly Asn Asn Gly Asp Arg Gly 
        35                  40                  45              


Arg Leu Leu Val Thr Asn Leu Arg Ile Leu Trp His Ser Leu Ala Leu 
    50                  55                  60                  


Ser Arg Val Asn Val Ser Val Gly Tyr Asn Cys Ile Leu Asn Ile Thr 
65                  70                  75                  80  


Thr Arg Thr Ala Asn Ser Lys Leu Arg Gly Gln Thr Glu Ala Leu Tyr 
                85                  90                  95      


Ile Leu Thr Lys Cys Asn Ser Thr Arg Phe Glu Phe Ile Phe Thr Asn 
            100                 105                 110         


Leu Val Pro Gly Ser Pro Arg Leu Phe Thr Ser Val Met Ala Val His 
        115                 120                 125             


Arg Ala Tyr Glu Thr Ser Lys Met Tyr Arg Asp Phe Lys Leu Arg Ser 
    130                 135                 140                 


Ala Leu Ile Gln Asn Lys Gln Leu Arg Leu Leu Pro Gln Glu His Val 
145                 150                 155                 160 


Tyr Asp Lys Ile Asn Gly Val Trp Asn Leu Ser Ser Asp Gln Gly Asn 
                165                 170                 175     


Leu Gly Thr Phe Phe Ile Thr Asn Val Arg Ile Val Trp His Ala Asn 
            180                 185                 190         


Met Asn Asp Ser Phe Asn Val Ser Ile Pro Tyr Leu Gln Ile Arg Ser 
        195                 200                 205             


Ile Lys Ile Arg Asp Ser Lys Phe Gly Leu Ala Leu Val Ile Glu Ser 
    210                 215                 220                 


Ser Gln Gln Ser Gly Gly Tyr Val Leu Gly Phe Lys Ile Asp Pro Val 
225                 230                 235                 240 


Glu Lys Leu Gln Glu Ser Val Lys Glu Ile Asn Ser Leu His Lys Val 
                245                 250                 255     


Tyr Ser Ala Ser Pro Ile Phe Gly Val Asp Tyr Glu Met Glu Glu Lys 
            260                 265                 270         


Pro Gln Pro Leu Glu Ala Leu Thr Val Glu Gln Ile Gln Asp Asp Val 
        275                 280                 285             


Glu Ile Asp Ser Asp Gly His Thr Asp Ala Phe Val Ala Tyr Phe Ala 
    290                 295                 300                 


Asp Gly Asn Lys Gln Gln Asp Arg Glu Pro Val Phe Ser Glu Glu Leu 
305                 310                 315                 320 


Gly Leu Ala Ile Glu Lys Leu Lys Asp Gly Phe Thr Leu Gln Gly Leu 
                325                 330                 335     


Trp Glu Val Met Ser 
            340     


<210>  116
<211>  341
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 5 (BBS5), ISOFORM 1 <Accession 
No.: AAT08182.1>

<400>  116

Met Ser Val Leu Asp Ala Leu Trp Glu Asp Arg Asp Val Arg Phe Asp 
1               5                   10                  15      


Leu Ser Ala Gln Gln Met Lys Thr Arg Pro Gly Glu Val Leu Ile Asp 
            20                  25                  30          


Cys Leu Asp Ser Ile Glu Asp Thr Lys Gly Asn Asn Gly Asp Arg Gly 
        35                  40                  45              


Arg Leu Leu Val Thr Asn Leu Arg Ile Leu Trp His Ser Leu Ala Leu 
    50                  55                  60                  


Ser Arg Val Asn Val Ser Val Gly Tyr Asn Cys Ile Leu Asn Ile Thr 
65                  70                  75                  80  


Thr Arg Thr Ala Asn Ser Lys Leu Arg Gly Gln Thr Glu Ala Leu Tyr 
                85                  90                  95      


Ile Leu Thr Lys Cys Asn Ser Thr Arg Phe Glu Phe Ile Phe Thr Asn 
            100                 105                 110         


Leu Val Pro Gly Ser Pro Arg Leu Phe Thr Ser Val Met Ala Val His 
        115                 120                 125             


Arg Ala Tyr Glu Thr Ser Lys Met Tyr Arg Asp Phe Lys Leu Arg Ser 
    130                 135                 140                 


Ala Leu Ile Gln Asn Lys Gln Leu Arg Leu Leu Pro Gln Glu His Val 
145                 150                 155                 160 


Tyr Asp Lys Ile Asn Gly Val Trp Asn Leu Ser Ser Asp Gln Gly Asn 
                165                 170                 175     


Leu Gly Thr Phe Phe Ile Thr Asn Val Arg Ile Val Trp His Ala Asn 
            180                 185                 190         


Met Asn Asp Ser Phe Asn Val Ser Ile Pro Tyr Leu Gln Ile Arg Ser 
        195                 200                 205             


Ile Lys Ile Arg Asp Ser Lys Phe Gly Leu Ala Leu Val Ile Glu Ser 
    210                 215                 220                 


Ser Gln Gln Ser Gly Gly Tyr Val Leu Gly Phe Lys Ile Asp Pro Val 
225                 230                 235                 240 


Glu Lys Leu Gln Glu Ser Val Lys Glu Ile Asn Ser Leu His Lys Val 
                245                 250                 255     


Tyr Ser Ala Ser Pro Ile Phe Gly Val Asp Tyr Glu Met Glu Glu Lys 
            260                 265                 270         


Pro Gln Pro Leu Glu Ala Leu Thr Val Glu Gln Ile Gln Asp Asp Val 
        275                 280                 285             


Glu Ile Asp Ser Asp Gly His Thr Asp Ala Phe Val Ala Tyr Phe Ala 
    290                 295                 300                 


Asp Gly Asn Lys Gln Gln Asp Arg Glu Pro Val Phe Ser Glu Glu Leu 
305                 310                 315                 320 


Gly Leu Ala Ile Glu Lys Leu Lys Asp Gly Phe Thr Leu Gln Gly Leu 
                325                 330                 335     


Trp Glu Val Met Ser 
            340     


<210>  117
<211>  320
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 5 (BBS5), ISOFORM 2 <Accession 
No.: AAT08183.1>

<400>  117

Met Ser Val Leu Asp Ala Leu Trp Glu Asp Arg Asp Val Arg Phe Asp 
1               5                   10                  15      


Leu Ser Ala Gln Gln Met Lys Thr Arg Pro Gly Glu Val Leu Ile Asp 
            20                  25                  30          


Cys Leu Asp Ser Ile Glu Asp Thr Lys Gly Asn Asn Gly Asp Arg Gly 
        35                  40                  45              


Arg Leu Leu Val Thr Asn Leu Arg Ile Leu Trp His Ser Leu Ala Leu 
    50                  55                  60                  


Ser Arg Val Asn Val Ser Val Gly Tyr Asn Cys Ile Leu Asn Ile Thr 
65                  70                  75                  80  


Thr Arg Thr Ala Asn Ser Lys Leu Arg Gly Gln Thr Glu Ala Leu Tyr 
                85                  90                  95      


Ile Leu Thr Lys Cys Asn Ser Thr Arg Phe Glu Phe Ile Phe Thr Asn 
            100                 105                 110         


Leu Val Pro Gly Ser Pro Arg Leu Phe Thr Ser Val Met Ala Val His 
        115                 120                 125             


Arg Ala Tyr Glu Thr Ser Lys Met Tyr Arg Asp Phe Lys Leu Arg Ser 
    130                 135                 140                 


Ala Leu Ile Gln Asn Lys Gln Leu Arg Leu Leu Pro Gln Glu His Val 
145                 150                 155                 160 


Tyr Asp Lys Ile Asn Gly Val Trp Asn Leu Ser Ser Asp Gln Gly Asn 
                165                 170                 175     


Leu Gly Thr Phe Phe Ile Thr Asn Val Arg Ile Val Trp His Ala Asn 
            180                 185                 190         


Met Asn Asp Ser Phe Asn Val Ser Ile Pro Tyr Leu Gln Ile Ser Gly 
        195                 200                 205             


Gly Tyr Val Leu Gly Phe Lys Ile Asp Pro Val Glu Lys Leu Gln Glu 
    210                 215                 220                 


Ser Val Lys Glu Ile Asn Ser Leu His Lys Val Tyr Ser Ala Ser Pro 
225                 230                 235                 240 


Ile Phe Gly Val Asp Tyr Glu Met Glu Glu Lys Pro Gln Pro Leu Glu 
                245                 250                 255     


Ala Leu Thr Val Glu Gln Ile Gln Asp Asp Val Glu Ile Asp Ser Asp 
            260                 265                 270         


Gly His Thr Asp Ala Phe Val Ala Tyr Phe Ala Asp Gly Asn Lys Gln 
        275                 280                 285             


Gln Asp Arg Glu Pro Val Phe Ser Glu Glu Leu Gly Leu Ala Ile Glu 
    290                 295                 300                 


Lys Leu Lys Asp Gly Phe Thr Leu Gln Gly Leu Trp Glu Val Met Ser 
305                 310                 315                 320 


<210>  118
<211>  570
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MCKUSICK-KAUFMAN SYNDROME (MKKS)  <Accession No.: AAH28973.1>

<400>  118

Met Ser Arg Leu Glu Ala Lys Lys Pro Ser Leu Cys Lys Ser Glu Pro 
1               5                   10                  15      


Leu Thr Thr Glu Arg Val Arg Thr Thr Leu Ser Val Leu Lys Arg Ile 
            20                  25                  30          


Val Thr Ser Cys Tyr Gly Pro Ser Gly Arg Leu Lys Gln Leu His Asn 
        35                  40                  45              


Gly Phe Gly Gly Tyr Val Cys Thr Thr Ser Gln Ser Ser Ala Leu Leu 
    50                  55                  60                  


Ser His Leu Leu Val Thr His Pro Ile Leu Lys Ile Leu Thr Ala Ser 
65                  70                  75                  80  


Ile Gln Asn His Val Ser Ser Phe Ser Asp Cys Gly Leu Phe Thr Ala 
                85                  90                  95      


Ile Leu Cys Cys Asn Leu Ile Glu Asn Val Gln Arg Leu Gly Leu Thr 
            100                 105                 110         


Pro Thr Thr Val Ile Arg Leu Asn Lys His Leu Leu Ser Leu Cys Ile 
        115                 120                 125             


Ser Tyr Leu Lys Ser Glu Thr Cys Gly Cys Arg Ile Pro Val Asp Phe 
    130                 135                 140                 


Ser Ser Thr Gln Ile Leu Leu Cys Leu Val Arg Ser Ile Leu Thr Ser 
145                 150                 155                 160 


Lys Pro Ala Cys Met Leu Thr Arg Lys Glu Thr Glu His Val Ser Ala 
                165                 170                 175     


Leu Ile Leu Arg Ala Phe Leu Leu Thr Ile Pro Glu Asn Ala Glu Gly 
            180                 185                 190         


His Ile Ile Leu Gly Lys Ser Leu Ile Val Pro Leu Lys Gly Gln Arg 
        195                 200                 205             


Val Ile Asp Ser Thr Val Leu Pro Gly Ile Leu Ile Glu Met Ser Glu 
    210                 215                 220                 


Val Gln Leu Met Arg Leu Leu Pro Ile Lys Lys Ser Thr Ala Leu Lys 
225                 230                 235                 240 


Val Ala Leu Phe Cys Thr Thr Leu Ser Gly Asp Thr Ser Asp Thr Gly 
                245                 250                 255     


Glu Gly Thr Val Val Val Ser Tyr Gly Val Ser Leu Glu Asn Ala Val 
            260                 265                 270         


Leu Asp Gln Leu Leu Asn Leu Gly Arg Gln Leu Ile Ser Asp His Val 
        275                 280                 285             


Asp Leu Val Leu Cys Gln Lys Val Ile His Pro Ser Leu Lys Gln Phe 
    290                 295                 300                 


Leu Asn Met His Arg Ile Ile Ala Ile Asp Arg Ile Gly Val Thr Leu 
305                 310                 315                 320 


Met Glu Pro Leu Thr Lys Met Thr Gly Thr Gln Pro Ile Gly Ser Leu 
                325                 330                 335     


Gly Ser Ile Cys Pro Asn Ser Tyr Gly Ser Val Lys Asp Val Cys Thr 
            340                 345                 350         


Ala Lys Phe Gly Ser Lys His Phe Phe His Leu Ile Pro Asn Glu Ala 
        355                 360                 365             


Thr Ile Cys Ser Leu Leu Leu Cys Asn Arg Asn Asp Thr Ala Trp Asp 
    370                 375                 380                 


Glu Leu Lys Leu Thr Cys Gln Thr Ala Leu His Val Leu Gln Leu Thr 
385                 390                 395                 400 


Leu Lys Glu Pro Trp Ala Leu Leu Gly Gly Gly Cys Thr Glu Thr His 
                405                 410                 415     


Leu Ala Ala Tyr Ile Arg His Lys Thr His Asn Asp Pro Glu Ser Ile 
            420                 425                 430         


Leu Lys Asp Asp Glu Cys Thr Gln Thr Glu Leu Gln Leu Ile Ala Glu 
        435                 440                 445             


Ala Phe Cys Ser Ala Leu Glu Ser Val Val Gly Ser Leu Glu His Asp 
    450                 455                 460                 


Gly Gly Glu Ile Leu Thr Asp Met Lys Tyr Gly His Leu Trp Ser Val 
465                 470                 475                 480 


Gln Ala Asp Ser Pro Cys Val Ala Asn Trp Pro Asp Leu Leu Ser Gln 
                485                 490                 495     


Cys Gly Cys Gly Leu Tyr Asn Ser Gln Glu Glu Leu Asn Trp Ser Phe 
            500                 505                 510         


Leu Arg Ser Thr Cys Arg Pro Phe Val Pro Gln Ser Cys Leu Pro His 
        515                 520                 525             


Glu Ala Val Val Ser Ala Ser Asn Leu Thr Leu Asp Cys Leu Thr Ala 
    530                 535                 540                 


Lys Leu Ser Gly Leu Gln Val Ala Val Glu Thr Ala Asn Leu Ile Leu 
545                 550                 555                 560 


Asp Leu Ser Tyr Val Ile Glu Asp Lys Asn 
                565                 570 


<210>  119
<211>  63
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MCKUSICK-KAUFMAN SYNDROME (MKKS), ISOFORM CRA_A <Accession 
No.: EAX10343.1>

<400>  119

Met Ser Leu Arg Asn Leu Trp Arg Asp Tyr Lys Val Leu Val Val Met 
1               5                   10                  15      


Val Pro Leu Val Gly Leu Ile His Leu Gly Trp Tyr Arg Ile Lys Ser 
            20                  25                  30          


Ser Pro Val Phe Gln Ile Pro Lys Asn Asp Asp Ile Pro Glu Gln Asp 
        35                  40                  45              


Ser Leu Gly Leu Ser Asn Leu Gln Lys Ser Gln Ile Gln Gly Lys 
    50                  55                  60              


<210>  120
<211>  570
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MCKUSICK-KAUFMAN SYNDROME (MKKS), ISOFORM CRA_B <Accession 
No.: EAX10344.1>

<400>  120

Met Ser Arg Leu Glu Ala Lys Lys Pro Ser Leu Cys Lys Ser Glu Pro 
1               5                   10                  15      


Leu Thr Thr Glu Arg Val Arg Thr Thr Leu Ser Val Leu Lys Arg Ile 
            20                  25                  30          


Val Thr Ser Cys Tyr Gly Pro Ser Gly Arg Leu Lys Gln Leu His Asn 
        35                  40                  45              


Gly Phe Gly Gly Tyr Val Cys Thr Thr Ser Gln Ser Ser Ala Leu Leu 
    50                  55                  60                  


Ser His Leu Leu Val Thr His Pro Ile Leu Lys Ile Leu Thr Ala Ser 
65                  70                  75                  80  


Ile Gln Asn His Val Ser Ser Phe Ser Asp Cys Gly Leu Phe Thr Ala 
                85                  90                  95      


Ile Leu Cys Cys Asn Leu Ile Glu Asn Val Gln Arg Leu Gly Leu Thr 
            100                 105                 110         


Pro Thr Thr Val Ile Arg Leu Asn Lys His Leu Leu Ser Leu Cys Ile 
        115                 120                 125             


Ser Tyr Leu Lys Ser Glu Thr Cys Gly Cys Arg Ile Pro Val Asp Phe 
    130                 135                 140                 


Ser Ser Thr Gln Ile Leu Leu Cys Leu Val Arg Ser Ile Leu Thr Ser 
145                 150                 155                 160 


Lys Pro Ala Cys Met Leu Thr Arg Lys Glu Thr Glu His Val Ser Ala 
                165                 170                 175     


Leu Ile Leu Arg Ala Phe Leu Leu Thr Ile Pro Glu Asn Ala Glu Gly 
            180                 185                 190         


His Ile Ile Leu Gly Lys Ser Leu Ile Val Pro Leu Lys Gly Gln Arg 
        195                 200                 205             


Val Ile Asp Ser Thr Val Leu Pro Gly Ile Leu Ile Glu Met Ser Glu 
    210                 215                 220                 


Val Gln Leu Met Arg Leu Leu Pro Ile Lys Lys Ser Thr Ala Leu Lys 
225                 230                 235                 240 


Val Ala Leu Phe Cys Thr Thr Leu Ser Gly Asp Thr Ser Asp Thr Gly 
                245                 250                 255     


Glu Gly Thr Val Val Val Ser Tyr Gly Val Ser Leu Glu Asn Ala Val 
            260                 265                 270         


Leu Asp Gln Leu Leu Asn Leu Gly Arg Gln Leu Ile Ser Asp His Val 
        275                 280                 285             


Asp Leu Val Leu Cys Gln Lys Val Ile His Pro Ser Leu Lys Gln Phe 
    290                 295                 300                 


Leu Asn Met His Arg Ile Ile Ala Ile Asp Arg Ile Gly Val Thr Leu 
305                 310                 315                 320 


Met Glu Pro Leu Thr Lys Met Thr Gly Thr Gln Pro Ile Gly Ser Leu 
                325                 330                 335     


Gly Ser Ile Cys Pro Asn Ser Tyr Gly Ser Val Lys Asp Val Cys Thr 
            340                 345                 350         


Ala Lys Phe Gly Ser Lys His Phe Phe His Leu Ile Pro Asn Glu Ala 
        355                 360                 365             


Thr Ile Cys Ser Leu Leu Leu Cys Asn Arg Asn Asp Thr Ala Trp Asp 
    370                 375                 380                 


Glu Leu Lys Leu Thr Cys Gln Thr Ala Leu His Val Leu Gln Leu Thr 
385                 390                 395                 400 


Leu Lys Glu Pro Trp Ala Leu Leu Gly Gly Gly Cys Thr Glu Thr His 
                405                 410                 415     


Leu Ala Ala Tyr Ile Arg His Lys Thr His Asn Asp Pro Glu Ser Ile 
            420                 425                 430         


Leu Lys Asp Asp Glu Cys Thr Gln Thr Glu Leu Gln Leu Ile Ala Glu 
        435                 440                 445             


Ala Phe Cys Ser Ala Leu Glu Ser Val Val Gly Ser Leu Glu His Asp 
    450                 455                 460                 


Gly Gly Glu Ile Leu Thr Asp Met Lys Tyr Gly His Leu Trp Ser Val 
465                 470                 475                 480 


Gln Ala Asp Ser Pro Cys Val Ala Asn Trp Pro Asp Leu Leu Ser Gln 
                485                 490                 495     


Cys Gly Cys Gly Leu Tyr Asn Ser Gln Glu Glu Leu Asn Trp Ser Phe 
            500                 505                 510         


Leu Arg Ser Thr Arg Arg Pro Phe Val Pro Gln Ser Cys Leu Pro His 
        515                 520                 525             


Glu Ala Val Gly Ser Ala Ser Asn Leu Thr Leu Asp Cys Leu Thr Ala 
    530                 535                 540                 


Lys Leu Ser Gly Leu Gln Val Ala Val Glu Thr Ala Asn Leu Ile Leu 
545                 550                 555                 560 


Asp Leu Ser Tyr Val Ile Glu Asp Lys Asn 
                565                 570 


<210>  121
<211>  672
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 7 (BBS7) <Accession No.: AAH32691.1>

<400>  121

Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr 
1               5                   10                  15      


Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr 
            20                  25                  30          


Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 
        35                  40                  45              


Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro 
    50                  55                  60                  


Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu 
65                  70                  75                  80  


Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg 
                85                  90                  95      


Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys 
            100                 105                 110         


Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 
        115                 120                 125             


Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 
145                 150                 155                 160 


Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 
                165                 170                 175     


Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val 
            180                 185                 190         


Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 
        195                 200                 205             


Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser 
    210                 215                 220                 


Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 
225                 230                 235                 240 


Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 
                245                 250                 255     


Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 
            260                 265                 270         


Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 
        275                 280                 285             


Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 
    290                 295                 300                 


Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu 
305                 310                 315                 320 


Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 
                325                 330                 335     


Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 
            340                 345                 350         


Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 
        355                 360                 365             


Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 
    370                 375                 380                 


Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 
385                 390                 395                 400 


Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 
                405                 410                 415     


Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 
            420                 425                 430         


Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln 
        435                 440                 445             


Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 
    450                 455                 460                 


Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr 
465                 470                 475                 480 


Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 
                485                 490                 495     


Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr 
            500                 505                 510         


Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 
        515                 520                 525             


Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr 
    530                 535                 540                 


Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys 
545                 550                 555                 560 


Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu 
                565                 570                 575     


Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn 
            580                 585                 590         


Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu 
        595                 600                 605             


Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 
    610                 615                 620                 


Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn 
625                 630                 635                 640 


Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 
                645                 650                 655     


Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 
            660                 665                 670         


<210>  122
<211>  715
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 7 (BBS7), ISOFORM A <Accession No.: 
NP_789794.1>

<400>  122

Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr 
1               5                   10                  15      


Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr 
            20                  25                  30          


Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 
        35                  40                  45              


Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro 
    50                  55                  60                  


Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu 
65                  70                  75                  80  


Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg 
                85                  90                  95      


Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys 
            100                 105                 110         


Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 
        115                 120                 125             


Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 
145                 150                 155                 160 


Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 
                165                 170                 175     


Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val 
            180                 185                 190         


Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 
        195                 200                 205             


Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser 
    210                 215                 220                 


Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 
225                 230                 235                 240 


Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 
                245                 250                 255     


Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 
            260                 265                 270         


Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 
        275                 280                 285             


Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 
    290                 295                 300                 


Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu 
305                 310                 315                 320 


Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 
                325                 330                 335     


Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 
            340                 345                 350         


Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 
        355                 360                 365             


Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 
    370                 375                 380                 


Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 
385                 390                 395                 400 


Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 
                405                 410                 415     


Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 
            420                 425                 430         


Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln 
        435                 440                 445             


Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 
    450                 455                 460                 


Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr 
465                 470                 475                 480 


Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 
                485                 490                 495     


Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr 
            500                 505                 510         


Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 
        515                 520                 525             


Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr 
    530                 535                 540                 


Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys 
545                 550                 555                 560 


Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu 
                565                 570                 575     


Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn 
            580                 585                 590         


Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu 
        595                 600                 605             


Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 
    610                 615                 620                 


Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn 
625                 630                 635                 640 


Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 
                645                 650                 655     


Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 
            660                 665                 670         


Met Ile Thr Asp Leu Phe Ile Asp Lys Phe Lys Phe Lys Gly Thr Asn 
        675                 680                 685             


Val Lys Thr Lys Val Pro Leu Leu Leu Glu Ile Leu Asp Ser Tyr Asp 
    690                 695                 700                 


Gln Asn Ala Leu Ile Ser Phe Phe Asp Ala Ala 
705                 710                 715 


<210>  123
<211>  672
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 7 (BBS7), ISOFORM B <Accession 
No.: NP_060660.2>

<400>  123

Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr 
1               5                   10                  15      


Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr 
            20                  25                  30          


Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 
        35                  40                  45              


Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro 
    50                  55                  60                  


Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu 
65                  70                  75                  80  


Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg 
                85                  90                  95      


Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys 
            100                 105                 110         


Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 
        115                 120                 125             


Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 
145                 150                 155                 160 


Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 
                165                 170                 175     


Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val 
            180                 185                 190         


Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 
        195                 200                 205             


Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser 
    210                 215                 220                 


Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 
225                 230                 235                 240 


Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 
                245                 250                 255     


Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 
            260                 265                 270         


Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 
        275                 280                 285             


Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 
    290                 295                 300                 


Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu 
305                 310                 315                 320 


Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 
                325                 330                 335     


Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 
            340                 345                 350         


Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 
        355                 360                 365             


Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 
    370                 375                 380                 


Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 
385                 390                 395                 400 


Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 
                405                 410                 415     


Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 
            420                 425                 430         


Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln 
        435                 440                 445             


Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 
    450                 455                 460                 


Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr 
465                 470                 475                 480 


Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 
                485                 490                 495     


Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr 
            500                 505                 510         


Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 
        515                 520                 525             


Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr 
    530                 535                 540                 


Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys 
545                 550                 555                 560 


Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu 
                565                 570                 575     


Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn 
            580                 585                 590         


Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu 
        595                 600                 605             


Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 
    610                 615                 620                 


Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn 
625                 630                 635                 640 


Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 
                645                 650                 655     


Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 
            660                 665                 670         


<210>  124
<211>  505
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TETRATRICOPEPTIDE REPEAT DOMAIN 8 (TTC8)  <Accession 
No.: AAH95433.1>

<400>  124

Met Ser Ser Glu Met Glu Pro Leu Leu Leu Ala Trp Ser Tyr Phe Arg 
1               5                   10                  15      


Arg Arg Lys Phe Gln Leu Cys Ala Asp Leu Cys Thr Gln Met Leu Glu 
            20                  25                  30          


Lys Ser Pro Tyr Asp Gln Ala Ala Trp Ile Leu Lys Ala Arg Ala Leu 
        35                  40                  45              


Thr Glu Met Val Tyr Ile Asp Glu Ile Asp Val Asp Gln Glu Gly Ile 
    50                  55                  60                  


Ala Glu Met Met Leu Asp Glu Asn Ala Ile Ala Gln Val Pro Arg Pro 
65                  70                  75                  80  


Gly Thr Ser Leu Lys Leu Pro Gly Thr Asn Gln Thr Gly Gly Pro Ser 
                85                  90                  95      


Gln Ala Val Arg Pro Ile Thr Gln Ala Gly Arg Pro Ile Thr Gly Phe 
            100                 105                 110         


Leu Arg Pro Ser Thr Gln Ser Gly Arg Pro Gly Thr Met Glu Gln Ala 
        115                 120                 125             


Ile Arg Thr Pro Arg Thr Ala Tyr Thr Ala Arg Pro Ile Thr Ser Ser 
    130                 135                 140                 


Ser Gly Arg Phe Val Arg Leu Gly Thr Ala Ser Met Leu Thr Ser Pro 
145                 150                 155                 160 


Asp Gly Pro Phe Ile Asn Leu Ser Arg Leu Asn Leu Thr Lys Tyr Ser 
                165                 170                 175     


Gln Lys Pro Lys Leu Ala Lys Ala Leu Phe Glu Tyr Ile Phe His His 
            180                 185                 190         


Glu Asn Asp Val Lys Thr Ala Leu Asp Leu Ala Ala Leu Ser Thr Glu 
        195                 200                 205             


His Ser Gln Tyr Lys Asp Trp Trp Trp Lys Val Gln Ile Gly Lys Cys 
    210                 215                 220                 


Tyr Tyr Arg Leu Gly Met Tyr Arg Glu Ala Glu Lys Gln Phe Lys Ser 
225                 230                 235                 240 


Ala Leu Lys Gln Gln Glu Met Val Asp Thr Phe Leu Tyr Leu Ala Lys 
                245                 250                 255     


Val Tyr Val Ser Leu Asp Gln Pro Val Thr Ala Leu Asn Leu Phe Lys 
            260                 265                 270         


Gln Gly Leu Asp Lys Phe Pro Gly Glu Val Thr Leu Leu Cys Gly Ile 
        275                 280                 285             


Ala Arg Ile Tyr Glu Glu Met Asn Asn Met Ser Ser Ala Ala Glu Tyr 
    290                 295                 300                 


Tyr Lys Glu Val Leu Lys Gln Asp Asn Thr His Val Glu Ala Ile Ala 
305                 310                 315                 320 


Cys Ile Gly Ser Asn His Phe Tyr Ser Asp Gln Pro Glu Ile Ala Leu 
                325                 330                 335     


Arg Phe Tyr Arg Arg Leu Leu Gln Met Gly Ile Tyr Asn Gly Gln Leu 
            340                 345                 350         


Phe Asn Asn Leu Gly Leu Cys Cys Phe Tyr Ala Gln Gln Tyr Asp Met 
        355                 360                 365             


Thr Leu Thr Ser Phe Glu Arg Ala Leu Ser Leu Ala Glu Asn Glu Glu 
    370                 375                 380                 


Glu Ala Ala Asp Val Trp Tyr Asn Leu Gly His Val Ala Val Gly Ile 
385                 390                 395                 400 


Gly Asp Thr Asn Leu Ala His Gln Cys Phe Arg Leu Ala Leu Val Asn 
                405                 410                 415     


Asn Asn Asn His Ala Glu Ala Tyr Asn Asn Leu Ala Val Leu Glu Met 
            420                 425                 430         


Arg Lys Gly His Val Glu Gln Ala Arg Ala Leu Leu Gln Thr Ala Ser 
        435                 440                 445             


Ser Leu Ala Pro His Met Tyr Glu Pro His Phe Asn Phe Ala Thr Ile 
    450                 455                 460                 


Ser Asp Lys Ile Gly Asp Leu Gln Arg Ser Tyr Val Ala Ala Gln Lys 
465                 470                 475                 480 


Ser Glu Ala Ala Phe Pro Asp His Val Asp Thr Gln His Leu Ile Lys 
                485                 490                 495     


Gln Leu Arg Gln His Phe Ala Met Leu 
            500                 505 


<210>  125
<211>  515
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TETRATRICOPEPTIDE REPEAT DOMAIN 8 (TTC8), ISOFORM A 
<Accession No.: NP_653197.2>

<400>  125

Met Ser Ser Glu Met Glu Pro Leu Leu Leu Ala Trp Ser Tyr Phe Arg 
1               5                   10                  15      


Arg Arg Lys Phe Gln Leu Cys Ala Asp Leu Cys Thr Gln Met Leu Glu 
            20                  25                  30          


Lys Ser Pro Tyr Asp Gln Glu Pro Asp Pro Glu Leu Pro Val His Gln 
        35                  40                  45              


Ala Ala Trp Ile Leu Lys Ala Arg Ala Leu Thr Glu Met Val Tyr Ile 
    50                  55                  60                  


Asp Glu Ile Asp Val Asp Gln Glu Gly Ile Ala Glu Met Met Leu Asp 
65                  70                  75                  80  


Glu Asn Ala Ile Ala Gln Val Pro Arg Pro Gly Thr Ser Leu Lys Leu 
                85                  90                  95      


Pro Gly Thr Asn Gln Thr Gly Gly Pro Ser Gln Ala Val Arg Pro Ile 
            100                 105                 110         


Thr Gln Ala Gly Arg Pro Ile Thr Gly Phe Leu Arg Pro Ser Thr Gln 
        115                 120                 125             


Ser Gly Arg Pro Gly Thr Met Glu Gln Ala Ile Arg Thr Pro Arg Thr 
    130                 135                 140                 


Ala Tyr Thr Ala Arg Pro Ile Thr Ser Ser Ser Gly Arg Phe Val Arg 
145                 150                 155                 160 


Leu Gly Thr Ala Ser Met Leu Thr Ser Pro Asp Gly Pro Phe Ile Asn 
                165                 170                 175     


Leu Ser Arg Leu Asn Leu Thr Lys Tyr Ser Gln Lys Pro Lys Leu Ala 
            180                 185                 190         


Lys Ala Leu Phe Glu Tyr Ile Phe His His Glu Asn Asp Val Lys Thr 
        195                 200                 205             


Ala Leu Asp Leu Ala Ala Leu Ser Thr Glu His Ser Gln Tyr Lys Asp 
    210                 215                 220                 


Trp Trp Trp Lys Val Gln Ile Gly Lys Cys Tyr Tyr Arg Leu Gly Met 
225                 230                 235                 240 


Tyr Arg Glu Ala Glu Lys Gln Phe Lys Ser Ala Leu Lys Gln Gln Glu 
                245                 250                 255     


Met Val Asp Thr Phe Leu Tyr Leu Ala Lys Val Tyr Val Ser Leu Asp 
            260                 265                 270         


Gln Pro Val Thr Ala Leu Asn Leu Phe Lys Gln Gly Leu Asp Lys Phe 
        275                 280                 285             


Pro Gly Glu Val Thr Leu Leu Cys Gly Ile Ala Arg Ile Tyr Glu Glu 
    290                 295                 300                 


Met Asn Asn Met Ser Ser Ala Ala Glu Tyr Tyr Lys Glu Val Leu Lys 
305                 310                 315                 320 


Gln Asp Asn Thr His Val Glu Ala Ile Ala Cys Ile Gly Ser Asn His 
                325                 330                 335     


Phe Tyr Ser Asp Gln Pro Glu Ile Ala Leu Arg Phe Tyr Arg Arg Leu 
            340                 345                 350         


Leu Gln Met Gly Ile Tyr Asn Gly Gln Leu Phe Asn Asn Leu Gly Leu 
        355                 360                 365             


Cys Cys Phe Tyr Ala Gln Gln Tyr Asp Met Thr Leu Thr Ser Phe Glu 
    370                 375                 380                 


Arg Ala Leu Ser Leu Ala Glu Asn Glu Glu Glu Ala Ala Asp Val Trp 
385                 390                 395                 400 


Tyr Asn Leu Gly His Val Ala Val Gly Ile Gly Asp Thr Asn Leu Ala 
                405                 410                 415     


His Gln Cys Phe Arg Leu Ala Leu Val Asn Asn Asn Asn His Ala Glu 
            420                 425                 430         


Ala Tyr Asn Asn Leu Ala Val Leu Glu Met Arg Lys Gly His Val Glu 
        435                 440                 445             


Gln Ala Arg Ala Leu Leu Gln Thr Ala Ser Ser Leu Ala Pro His Met 
    450                 455                 460                 


Tyr Glu Pro His Phe Asn Phe Ala Thr Ile Ser Asp Lys Ile Gly Asp 
465                 470                 475                 480 


Leu Gln Arg Ser Tyr Val Ala Ala Gln Lys Ser Glu Ala Ala Phe Pro 
                485                 490                 495     


Asp His Val Asp Thr Gln His Leu Ile Lys Gln Leu Arg Gln His Phe 
            500                 505                 510         


Ala Met Leu 
        515 


<210>  126
<211>  505
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TETRATRICOPEPTIDE REPEAT DOMAIN 8 (TTC8), ISOFORM B 
<Accession No.: NP_938051.1>

<400>  126

Met Ser Ser Glu Met Glu Pro Leu Leu Leu Ala Trp Ser Tyr Phe Arg 
1               5                   10                  15      


Arg Arg Lys Phe Gln Leu Cys Ala Asp Leu Cys Thr Gln Met Leu Glu 
            20                  25                  30          


Lys Ser Pro Tyr Asp Gln Ala Ala Trp Ile Leu Lys Ala Arg Ala Leu 
        35                  40                  45              


Thr Glu Met Val Tyr Ile Asp Glu Ile Asp Val Asp Gln Glu Gly Ile 
    50                  55                  60                  


Ala Glu Met Met Leu Asp Glu Asn Ala Ile Ala Gln Val Pro Arg Pro 
65                  70                  75                  80  


Gly Thr Ser Leu Lys Leu Pro Gly Thr Asn Gln Thr Gly Gly Pro Ser 
                85                  90                  95      


Gln Ala Val Arg Pro Ile Thr Gln Ala Gly Arg Pro Ile Thr Gly Phe 
            100                 105                 110         


Leu Arg Pro Ser Thr Gln Ser Gly Arg Pro Gly Thr Met Glu Gln Ala 
        115                 120                 125             


Ile Arg Thr Pro Arg Thr Ala Tyr Thr Ala Arg Pro Ile Thr Ser Ser 
    130                 135                 140                 


Ser Gly Arg Phe Val Arg Leu Gly Thr Ala Ser Met Leu Thr Ser Pro 
145                 150                 155                 160 


Asp Gly Pro Phe Ile Asn Leu Ser Arg Leu Asn Leu Thr Lys Tyr Ser 
                165                 170                 175     


Gln Lys Pro Lys Leu Ala Lys Ala Leu Phe Glu Tyr Ile Phe His His 
            180                 185                 190         


Glu Asn Asp Val Lys Thr Ala Leu Asp Leu Ala Ala Leu Ser Thr Glu 
        195                 200                 205             


His Ser Gln Tyr Lys Asp Trp Trp Trp Lys Val Gln Ile Gly Lys Cys 
    210                 215                 220                 


Tyr Tyr Arg Leu Gly Met Tyr Arg Glu Ala Glu Lys Gln Phe Lys Ser 
225                 230                 235                 240 


Ala Leu Lys Gln Gln Glu Met Val Asp Thr Phe Leu Tyr Leu Ala Lys 
                245                 250                 255     


Val Tyr Val Ser Leu Asp Gln Pro Val Thr Ala Leu Asn Leu Phe Lys 
            260                 265                 270         


Gln Gly Leu Asp Lys Phe Pro Gly Glu Val Thr Leu Leu Cys Gly Ile 
        275                 280                 285             


Ala Arg Ile Tyr Glu Glu Met Asn Asn Met Ser Ser Ala Ala Glu Tyr 
    290                 295                 300                 


Tyr Lys Glu Val Leu Lys Gln Asp Asn Thr His Val Glu Ala Ile Ala 
305                 310                 315                 320 


Cys Ile Gly Ser Asn His Phe Tyr Ser Asp Gln Pro Glu Ile Ala Leu 
                325                 330                 335     


Arg Phe Tyr Arg Arg Leu Leu Gln Met Gly Ile Tyr Asn Gly Gln Leu 
            340                 345                 350         


Phe Asn Asn Leu Gly Leu Cys Cys Phe Tyr Ala Gln Gln Tyr Asp Met 
        355                 360                 365             


Thr Leu Thr Ser Phe Glu Arg Ala Leu Ser Leu Ala Glu Asn Glu Glu 
    370                 375                 380                 


Glu Ala Ala Asp Val Trp Tyr Asn Leu Gly His Val Ala Val Gly Ile 
385                 390                 395                 400 


Gly Asp Thr Asn Leu Ala His Gln Cys Phe Arg Leu Ala Leu Val Asn 
                405                 410                 415     


Asn Asn Asn His Ala Glu Ala Tyr Asn Asn Leu Ala Val Leu Glu Met 
            420                 425                 430         


Arg Lys Gly His Val Glu Gln Ala Arg Ala Leu Leu Gln Thr Ala Ser 
        435                 440                 445             


Ser Leu Ala Pro His Met Tyr Glu Pro His Phe Asn Phe Ala Thr Ile 
    450                 455                 460                 


Ser Asp Lys Ile Gly Asp Leu Gln Arg Ser Tyr Val Ala Ala Gln Lys 
465                 470                 475                 480 


Ser Glu Ala Ala Phe Pro Asp His Val Asp Thr Gln His Leu Ile Lys 
                485                 490                 495     


Gln Leu Arg Gln His Phe Ala Met Leu 
            500                 505 


<210>  127
<211>  887
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 9 (BBS9) <Accession No.: AAI03832.1>

<400>  127

Met Ser Leu Phe Lys Ala Arg Asp Trp Trp Ser Thr Ile Leu Gly Asp 
1               5                   10                  15      


Lys Glu Glu Phe Asp Gln Gly Cys Leu Cys Leu Ala Asn Val Asp Asn 
            20                  25                  30          


Ser Gly Asn Gly Gln Asp Lys Ile Ile Val Gly Ser Phe Met Gly Tyr 
        35                  40                  45              


Leu Arg Ile Phe Ser Pro His Pro Ala Lys Thr Gly Asp Gly Ala Gln 
    50                  55                  60                  


Ala Glu Asp Leu Leu Leu Glu Val Asp Leu Arg Asp Pro Val Leu Gln 
65                  70                  75                  80  


Val Glu Val Gly Lys Phe Val Ser Gly Thr Glu Met Leu His Leu Ala 
                85                  90                  95      


Val Leu His Ser Arg Lys Leu Cys Val Tyr Ser Val Ser Gly Thr Leu 
            100                 105                 110         


Gly Asn Val Glu His Gly Asn Gln Cys Gln Met Lys Leu Met Tyr Glu 
        115                 120                 125             


His Asn Leu Gln Arg Thr Ala Cys Asn Met Thr Tyr Gly Ser Phe Gly 
    130                 135                 140                 


Gly Val Lys Gly Arg Asp Leu Ile Cys Ile Gln Ser Met Asp Gly Met 
145                 150                 155                 160 


Leu Met Val Phe Glu Gln Glu Ser Tyr Ala Phe Gly Arg Phe Leu Pro 
                165                 170                 175     


Gly Phe Leu Leu Pro Gly Pro Leu Ala Tyr Ser Ser Arg Thr Asp Ser 
            180                 185                 190         


Phe Leu Thr Val Ser Ser Cys Gln Gln Val Glu Ser Tyr Lys Tyr Gln 
        195                 200                 205             


Val Leu Ala Phe Ala Thr Asp Ala Asp Lys Arg Gln Glu Thr Glu Gln 
    210                 215                 220                 


Gln Lys Leu Gly Ser Gly Lys Arg Leu Val Val Asp Trp Thr Leu Asn 
225                 230                 235                 240 


Ile Gly Glu Gln Ala Leu Asp Ile Cys Ile Val Ser Phe Asn Gln Ser 
                245                 250                 255     


Ala Ser Ser Val Phe Val Leu Gly Glu Arg Asn Phe Phe Cys Leu Lys 
            260                 265                 270         


Asp Asn Gly Gln Ile Arg Phe Met Lys Lys Leu Asp Trp Ser Pro Ser 
        275                 280                 285             


Cys Phe Leu Pro Tyr Cys Ser Val Ser Glu Gly Thr Ile Asn Thr Leu 
    290                 295                 300                 


Ile Gly Asn His Asn Asn Met Leu His Ile Tyr Gln Asp Val Thr Leu 
305                 310                 315                 320 


Lys Trp Ala Thr Gln Leu Pro His Ile Pro Val Ala Val Arg Val Gly 
                325                 330                 335     


Cys Leu His Asp Leu Lys Gly Val Ile Val Thr Leu Ser Asp Asp Gly 
            340                 345                 350         


His Leu Gln Cys Ser Tyr Leu Gly Thr Asp Pro Ser Leu Phe Gln Ala 
        355                 360                 365             


Pro Asn Val Gln Ser Arg Glu Leu Asn Tyr Asp Glu Leu Asp Val Glu 
    370                 375                 380                 


Met Lys Glu Leu Gln Lys Ile Ile Lys Asp Val Asn Lys Ser Gln Gly 
385                 390                 395                 400 


Val Trp Pro Met Thr Glu Arg Glu Asp Asp Leu Asn Val Ser Val Val 
                405                 410                 415     


Val Ser Pro Asn Phe Asp Ser Val Ser Gln Ala Thr Asp Val Glu Val 
            420                 425                 430         


Gly Thr Asp Leu Val Pro Ser Val Thr Val Lys Val Thr Leu Gln Asn 
        435                 440                 445             


Arg Val Ile Leu Gln Lys Ala Lys Leu Ser Val Tyr Val Gln Pro Pro 
    450                 455                 460                 


Leu Glu Leu Thr Cys Asp Gln Phe Thr Phe Glu Phe Met Thr Pro Asp 
465                 470                 475                 480 


Leu Thr Arg Thr Val Ser Phe Ser Val Tyr Leu Lys Arg Ser Tyr Thr 
                485                 490                 495     


Pro Ser Glu Leu Glu Gly Asn Ala Val Val Ser Tyr Ser Arg Pro Thr 
            500                 505                 510         


Asp Arg Asn Pro Asp Gly Ile Pro Arg Val Ile Gln Cys Lys Phe Arg 
        515                 520                 525             


Leu Pro Leu Lys Leu Ile Cys Leu Pro Gly Gln Pro Ser Lys Thr Ala 
    530                 535                 540                 


Ser His Lys Ile Thr Ile Asp Thr Asn Lys Ser Pro Val Ser Leu Leu 
545                 550                 555                 560 


Ser Leu Phe Pro Gly Phe Ala Ser Gln Ser Asp Asp Asp Gln Val Asn 
                565                 570                 575     


Val Met Gly Phe His Phe Leu Gly Gly Ala Arg Ile Thr Val Leu Ala 
            580                 585                 590         


Ser Lys Thr Ser Gln Arg Tyr Arg Ile Gln Ser Glu Gln Phe Glu Asp 
        595                 600                 605             


Leu Trp Leu Ile Thr Asn Glu Leu Ile Leu Arg Leu Gln Glu Tyr Phe 
    610                 615                 620                 


Glu Lys Gln Gly Val Lys Asp Phe Ala Cys Ser Phe Ser Gly Ser Ile 
625                 630                 635                 640 


Pro Leu Gln Glu Tyr Phe Glu Leu Ile Asp His His Phe Glu Leu Arg 
                645                 650                 655     


Ile Asn Gly Glu Lys Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln 
            660                 665                 670         


Phe Arg Ala Ile Gln Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr 
        675                 680                 685             


Pro Ala Pro Leu Gln His Leu Asp Thr Leu Leu Asp Gly Thr Tyr Lys 
    690                 695                 700                 


Gln Val Ile Ala Leu Ala Asp Ala Val Glu Glu Asn Gln Gly Asn Leu 
705                 710                 715                 720 


Phe Gln Ser Phe Thr Arg Leu Lys Ser Ala Thr His Leu Val Ile Leu 
                725                 730                 735     


Leu Ile Ala Leu Trp Gln Lys Leu Ser Ala Asp Gln Val Ala Ile Leu 
            740                 745                 750         


Glu Ala Ala Phe Leu Pro Leu Gln Glu Asp Thr Gln Glu Leu Gly Trp 
        755                 760                 765             


Glu Glu Thr Val Asp Ala Ala Ile Ser His Leu Leu Lys Thr Cys Leu 
    770                 775                 780                 


Ser Lys Ser Ser Lys Glu Gln Ala Leu Asn Leu Asn Ser Gln Leu Asn 
785                 790                 795                 800 


Ile Pro Lys Asp Thr Ser Gln Leu Lys Lys His Ile Thr Leu Leu Cys 
                805                 810                 815     


Asp Arg Leu Ser Lys Gly Gly Arg Leu Cys Leu Ser Thr Asp Ala Ala 
            820                 825                 830         


Ala Pro Gln Thr Met Val Met Pro Gly Gly Cys Thr Thr Ile Pro Glu 
        835                 840                 845             


Ser Asp Leu Glu Glu Arg Ser Val Glu Gln Asp Ser Thr Glu Leu Phe 
    850                 855                 860                 


Thr Asn His Arg His Leu Thr Ala Glu Thr Pro Arg Pro Glu Val Ser 
865                 870                 875                 880 


Pro Leu Gln Gly Val Ser Glu 
                885         


<210>  128
<211>  723
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 10 (BBS10) <Accession No.: AAH26355.2>

<400>  128

Met Leu Ser Ser Met Ala Ala Ala Gly Ser Val Lys Ala Ala Leu Gln 
1               5                   10                  15      


Val Ala Glu Val Leu Glu Ala Ile Val Ser Cys Cys Val Gly Pro Glu 
            20                  25                  30          


Gly Arg Gln Val Leu Cys Thr Lys Pro Thr Gly Glu Val Leu Leu Ser 
        35                  40                  45              


Arg Asn Gly Gly Arg Leu Leu Glu Ala Leu His Leu Glu His Pro Ile 
    50                  55                  60                  


Ala Arg Met Ile Val Asp Cys Val Ser Ser His Leu Lys Lys Thr Gly 
65                  70                  75                  80  


Asp Gly Ala Lys Thr Phe Ile Ile Phe Leu Cys His Leu Leu Arg Gly 
                85                  90                  95      


Leu His Ala Ile Thr Asp Arg Glu Lys Asp Pro Leu Met Cys Glu Asn 
            100                 105                 110         


Ile Gln Thr His Gly Arg His Trp Lys Asn Cys Ser Arg Trp Lys Phe 
        115                 120                 125             


Ile Ser Gln Ala Leu Leu Thr Phe Gln Thr Gln Ile Leu Asp Gly Ile 
    130                 135                 140                 


Met Asp Gln Tyr Leu Ser Arg His Phe Leu Ser Ile Phe Ser Ser Ala 
145                 150                 155                 160 


Lys Glu Arg Thr Leu Cys Arg Ser Ser Leu Glu Leu Leu Leu Glu Ala 
                165                 170                 175     


Tyr Phe Cys Gly Arg Val Gly Arg Asn Asn His Lys Phe Ile Ser Gln 
            180                 185                 190         


Leu Met Cys Asp Tyr Phe Phe Lys Cys Met Thr Cys Lys Ser Gly Ile 
        195                 200                 205             


Gly Val Phe Glu Leu Val Asp Asp His Phe Val Glu Leu Asn Val Gly 
    210                 215                 220                 


Val Thr Gly Leu Pro Val Ser Asp Ser Arg Ile Ile Ala Gly Leu Val 
225                 230                 235                 240 


Leu Gln Lys Asp Phe Ser Val Tyr Arg Pro Ala Asp Gly Asp Met Arg 
                245                 250                 255     


Met Val Ile Val Thr Glu Thr Ile Gln Pro Leu Phe Ser Thr Ser Gly 
            260                 265                 270         


Ser Glu Phe Ile Leu Asn Ser Glu Ala Gln Phe Gln Thr Ser Gln Phe 
        275                 280                 285             


Trp Ile Met Glu Lys Thr Lys Ala Ile Met Lys His Leu His Ser Gln 
    290                 295                 300                 


Asn Val Lys Leu Leu Ile Ser Ser Val Lys Gln Pro Asp Leu Val Ser 
305                 310                 315                 320 


Tyr Tyr Ala Gly Val Asn Gly Ile Ser Val Val Glu Cys Leu Ser Ser 
                325                 330                 335     


Glu Glu Val Ser Leu Ile Arg Arg Ile Ile Gly Leu Ser Pro Phe Val 
            340                 345                 350         


Pro Pro Gln Ala Phe Ser Gln Cys Glu Ile Pro Asn Thr Ala Leu Val 
        355                 360                 365             


Lys Phe Cys Lys Pro Leu Ile Leu Arg Ser Lys Arg Tyr Val His Leu 
    370                 375                 380                 


Gly Leu Ile Ser Thr Cys Ala Phe Ile Pro His Ser Ile Val Leu Cys 
385                 390                 395                 400 


Gly Pro Val His Gly Leu Ile Glu Gln His Glu Asp Ala Leu His Gly 
                405                 410                 415     


Ala Leu Lys Met Leu Arg Gln Leu Phe Lys Asp Leu Asp Leu Asn Tyr 
            420                 425                 430         


Met Thr Gln Thr Asn Asp Gln Asn Gly Thr Ser Ser Leu Phe Ile Tyr 
        435                 440                 445             


Lys Asn Ser Gly Glu Ser Tyr Gln Ala Pro Asp Pro Gly Asn Gly Ser 
    450                 455                 460                 


Ile Gln Arg Pro Tyr Gln Asp Thr Val Ala Glu Asn Lys Asp Ala Leu 
465                 470                 475                 480 


Glu Lys Thr Gln Thr Tyr Leu Lys Val His Ser Asn Leu Val Ile Pro 
                485                 490                 495     


Asp Val Glu Leu Glu Thr Tyr Ile Pro Tyr Ser Thr Pro Thr Leu Thr 
            500                 505                 510         


Pro Thr Asp Thr Phe Gln Thr Val Glu Thr Leu Thr Cys Leu Ser Leu 
        515                 520                 525             


Glu Arg Asn Arg Leu Thr Asp Tyr Tyr Glu Pro Leu Leu Lys Asn Asn 
    530                 535                 540                 


Ser Thr Ala Tyr Ser Thr Arg Gly Asn Arg Ile Glu Ile Ser Tyr Glu 
545                 550                 555                 560 


Asn Leu Gln Val Thr Asn Ile Thr Arg Lys Gly Ser Met Leu Pro Val 
                565                 570                 575     


Ser Cys Lys Leu Pro Asn Met Gly Thr Ser Gln Ser Tyr Leu Ser Ser 
            580                 585                 590         


Ser Met Pro Ala Gly Cys Val Leu Pro Val Gly Gly Asn Phe Asp Ile 
        595                 600                 605             


Leu Leu His Tyr Tyr Leu Leu Asn Tyr Ala Lys Lys Cys His Gln Ser 
    610                 615                 620                 


Glu Glu Thr Met Val Ser Met Ile Ile Ala Asn Ala Leu Leu Gly Ile 
625                 630                 635                 640 


Pro Lys Val Leu Tyr Lys Ser Lys Thr Gly Lys Tyr Ser Phe Pro His 
                645                 650                 655     


Thr Tyr Ile Arg Ala Val His Ala Leu Gln Thr Asn Gln Pro Leu Val 
            660                 665                 670         


Ser Ser Gln Thr Gly Leu Glu Ser Val Met Gly Lys Tyr Gln Leu Leu 
        675                 680                 685             


Thr Ser Val Leu Gln Cys Leu Thr Lys Ile Leu Thr Ile Asp Met Val 
    690                 695                 700                 


Ile Thr Val Lys Arg His Pro Gln Lys Val His Asn Gln Asp Ser Glu 
705                 710                 715                 720 


Asp Glu Leu 
            


<210>  129
<211>  653
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRIPARTITE MOTIF CONTAINING 32 (TRIM32)  <Accession 
No.: AAH03154.1>

<400>  129

Met Ala Ala Ala Ala Ala Ser His Leu Asn Leu Asp Ala Leu Arg Glu 
1               5                   10                  15      


Val Leu Glu Cys Pro Ile Cys Met Glu Ser Phe Thr Glu Glu Gln Leu 
            20                  25                  30          


Arg Pro Lys Leu Leu His Cys Gly His Thr Ile Cys Arg Gln Cys Leu 
        35                  40                  45              


Glu Lys Leu Leu Ala Ser Ser Ile Asn Gly Val Arg Cys Pro Phe Cys 
    50                  55                  60                  


Ser Lys Ile Thr Arg Ile Thr Ser Leu Thr Gln Leu Thr Asp Asn Leu 
65                  70                  75                  80  


Thr Val Leu Lys Ile Ile Asp Thr Ala Gly Leu Ser Glu Ala Val Gly 
                85                  90                  95      


Leu Leu Met Cys Arg Ser Cys Gly Arg Arg Leu Pro Arg Gln Phe Cys 
            100                 105                 110         


Arg Ser Cys Gly Leu Val Leu Cys Glu Pro Cys Arg Glu Ala Asp His 
        115                 120                 125             


Gln Pro Pro Gly His Cys Thr Leu Pro Val Lys Glu Ala Ala Glu Glu 
    130                 135                 140                 


Arg Arg Arg Asp Phe Gly Glu Lys Leu Thr Arg Leu Arg Glu Leu Met 
145                 150                 155                 160 


Gly Glu Leu Gln Arg Arg Lys Ala Ala Leu Glu Gly Val Ser Lys Asp 
                165                 170                 175     


Leu Gln Ala Arg Tyr Lys Ala Val Leu Gln Glu Tyr Gly His Glu Glu 
            180                 185                 190         


Arg Arg Val Gln Asp Glu Leu Ala Arg Ser Arg Lys Phe Phe Thr Gly 
        195                 200                 205             


Ser Leu Ala Glu Val Glu Lys Ser Asn Ser Gln Val Val Glu Glu Gln 
    210                 215                 220                 


Ser Tyr Leu Leu Asn Ile Ala Glu Val Gln Ala Val Ser Arg Cys Asp 
225                 230                 235                 240 


Tyr Phe Leu Ala Lys Ile Lys Gln Ala Asp Val Ala Leu Leu Glu Glu 
                245                 250                 255     


Thr Ala Asp Glu Glu Glu Pro Glu Leu Thr Ala Ser Leu Pro Arg Glu 
            260                 265                 270         


Leu Thr Leu Gln Asp Val Glu Leu Leu Lys Val Gly His Val Gly Pro 
        275                 280                 285             


Leu Gln Ile Gly Gln Ala Val Lys Lys Pro Arg Thr Val Asn Val Glu 
    290                 295                 300                 


Asp Ser Trp Ala Met Glu Ala Thr Ala Ser Ala Ala Ser Thr Ser Val 
305                 310                 315                 320 


Thr Phe Arg Glu Met Asp Met Ser Pro Glu Glu Val Val Ala Ser Pro 
                325                 330                 335     


Arg Ala Ser Pro Ala Lys Gln Arg Gly Pro Glu Ala Ala Ser Asn Ile 
            340                 345                 350         


Gln Gln Cys Leu Phe Leu Lys Lys Met Gly Ala Lys Gly Ser Thr Pro 
        355                 360                 365             


Gly Met Phe Asn Leu Pro Val Ser Leu Tyr Val Thr Ser Gln Gly Glu 
    370                 375                 380                 


Val Leu Val Ala Asp Arg Gly Asn Tyr Arg Ile Gln Val Phe Thr Arg 
385                 390                 395                 400 


Lys Gly Phe Leu Lys Glu Ile Arg Arg Ser Pro Ser Gly Ile Asp Ser 
                405                 410                 415     


Phe Val Leu Ser Phe Leu Gly Ala Asp Leu Pro Asn Leu Thr Pro Leu 
            420                 425                 430         


Ser Val Ala Met Asn Cys Gln Gly Leu Ile Gly Val Thr Asp Ser Tyr 
        435                 440                 445             


Asp Asn Ser Leu Lys Val Tyr Thr Leu Asp Gly His Cys Val Ala Cys 
    450                 455                 460                 


His Arg Ser Gln Leu Ser Lys Pro Trp Gly Ile Thr Ala Leu Pro Ser 
465                 470                 475                 480 


Gly Gln Phe Val Val Thr Asp Val Glu Gly Gly Lys Leu Trp Cys Phe 
                485                 490                 495     


Thr Val Asp Arg Gly Ser Gly Val Val Lys Tyr Ser Cys Leu Cys Ser 
            500                 505                 510         


Ala Val Arg Pro Lys Phe Val Thr Cys Asp Ala Glu Gly Thr Val Tyr 
        515                 520                 525             


Phe Thr Gln Gly Leu Gly Leu Asn Leu Glu Asn Arg Gln Asn Glu His 
    530                 535                 540                 


His Leu Glu Gly Gly Phe Ser Ile Gly Ser Val Gly Pro Asp Gly Gln 
545                 550                 555                 560 


Leu Gly Arg Gln Ile Ser His Phe Phe Ser Glu Asn Glu Asp Phe Arg 
                565                 570                 575     


Cys Ile Ala Gly Met Cys Val Asp Ala Arg Gly Asp Leu Ile Val Ala 
            580                 585                 590         


Asp Ser Ser Arg Lys Glu Ile Leu His Phe Pro Lys Gly Gly Gly Tyr 
        595                 600                 605             


Ser Val Leu Ile Arg Glu Gly Leu Thr Cys Pro Val Gly Ile Ala Leu 
    610                 615                 620                 


Thr Pro Lys Gly Gln Leu Leu Val Leu Asp Cys Trp Asp His Cys Ile 
625                 630                 635                 640 


Lys Ile Tyr Ser Tyr His Leu Arg Arg Tyr Ser Thr Pro 
                645                 650             


<210>  130
<211>  653
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRIPARTITE MOTIF CONTAINING 32 (TRIM32), ISOFORM CRA_A 
<Accession No.: EAW87447.1>

<400>  130

Met Ala Ala Ala Ala Ala Ser His Leu Asn Leu Asp Ala Leu Arg Glu 
1               5                   10                  15      


Val Leu Glu Cys Pro Ile Cys Met Glu Ser Phe Thr Glu Glu Gln Leu 
            20                  25                  30          


Arg Pro Lys Leu Leu His Cys Gly His Thr Ile Cys Arg Gln Cys Leu 
        35                  40                  45              


Glu Lys Leu Leu Ala Ser Ser Ile Asn Gly Val Arg Cys Pro Phe Cys 
    50                  55                  60                  


Ser Lys Ile Thr Arg Ile Thr Ser Leu Thr Gln Leu Thr Asp Asn Leu 
65                  70                  75                  80  


Thr Val Leu Lys Ile Ile Asp Thr Ala Gly Leu Ser Glu Ala Val Gly 
                85                  90                  95      


Leu Leu Met Cys Arg Ser Cys Gly Arg Arg Leu Pro Arg Gln Phe Cys 
            100                 105                 110         


Arg Ser Cys Gly Leu Val Leu Cys Glu Pro Cys Arg Glu Ala Asp His 
        115                 120                 125             


Gln Pro Pro Gly His Cys Thr Leu Pro Val Lys Glu Ala Ala Glu Glu 
    130                 135                 140                 


Arg Arg Arg Asp Phe Gly Glu Lys Leu Thr Arg Leu Arg Glu Leu Met 
145                 150                 155                 160 


Gly Glu Leu Gln Arg Arg Lys Ala Ala Leu Glu Gly Val Ser Lys Asp 
                165                 170                 175     


Leu Gln Ala Arg Tyr Lys Ala Val Leu Gln Glu Tyr Gly His Glu Glu 
            180                 185                 190         


Arg Arg Val Gln Asp Glu Leu Ala Arg Ser Arg Lys Phe Phe Thr Gly 
        195                 200                 205             


Ser Leu Ala Glu Val Glu Lys Ser Asn Ser Gln Val Val Glu Glu Gln 
    210                 215                 220                 


Ser Tyr Leu Leu Asn Ile Ala Glu Val Gln Ala Val Ser Arg Cys Asp 
225                 230                 235                 240 


Tyr Phe Leu Ala Lys Ile Lys Gln Ala Asp Val Ala Leu Leu Glu Glu 
                245                 250                 255     


Thr Ala Asp Glu Glu Glu Pro Glu Leu Thr Ala Ser Leu Pro Arg Glu 
            260                 265                 270         


Leu Thr Leu Gln Asp Val Glu Leu Leu Lys Val Gly His Val Gly Pro 
        275                 280                 285             


Leu Gln Ile Gly Gln Ala Val Lys Lys Pro Arg Thr Val Asn Val Glu 
    290                 295                 300                 


Asp Ser Trp Ala Met Glu Ala Thr Ala Ser Ala Ala Ser Thr Ser Val 
305                 310                 315                 320 


Thr Phe Arg Glu Met Asp Met Ser Pro Glu Glu Val Val Ala Ser Pro 
                325                 330                 335     


Arg Ala Ser Pro Ala Lys Gln Arg Gly Pro Glu Ala Ala Ser Asn Ile 
            340                 345                 350         


Gln Gln Cys Leu Phe Leu Lys Lys Met Gly Ala Lys Gly Ser Thr Pro 
        355                 360                 365             


Gly Met Phe Asn Leu Pro Val Ser Leu Tyr Val Thr Ser Gln Gly Glu 
    370                 375                 380                 


Val Leu Val Ala Asp Arg Gly Asn Tyr Arg Ile Gln Val Phe Thr Arg 
385                 390                 395                 400 


Lys Gly Phe Leu Lys Glu Ile Arg Arg Ser Pro Ser Gly Ile Asp Ser 
                405                 410                 415     


Phe Val Leu Ser Phe Leu Gly Ala Asp Leu Pro Asn Leu Thr Pro Leu 
            420                 425                 430         


Ser Val Ala Met Asn Cys Gln Gly Leu Ile Gly Val Thr Asp Ser Tyr 
        435                 440                 445             


Asp Asn Ser Leu Lys Val Tyr Thr Leu Asp Gly His Cys Val Ala Cys 
    450                 455                 460                 


His Arg Ser Gln Leu Ser Lys Pro Trp Gly Ile Thr Ala Leu Pro Ser 
465                 470                 475                 480 


Gly Gln Phe Val Val Thr Asp Val Glu Gly Gly Lys Leu Trp Cys Phe 
                485                 490                 495     


Thr Val Asp Arg Gly Ser Gly Val Val Lys Tyr Ser Cys Leu Cys Ser 
            500                 505                 510         


Ala Val Arg Pro Lys Phe Val Thr Cys Asp Ala Glu Gly Thr Val Tyr 
        515                 520                 525             


Phe Thr Gln Gly Leu Gly Leu Asn Leu Glu Asn Arg Gln Asn Glu His 
    530                 535                 540                 


His Leu Glu Gly Gly Phe Ser Ile Gly Ser Val Gly Pro Asp Gly Gln 
545                 550                 555                 560 


Leu Gly Arg Gln Ile Ser His Phe Phe Ser Glu Asn Glu Asp Phe Arg 
                565                 570                 575     


Cys Ile Ala Gly Met Cys Val Asp Ala Arg Gly Asp Leu Ile Val Ala 
            580                 585                 590         


Asp Ser Ser Arg Lys Glu Ile Leu His Phe Pro Lys Gly Gly Gly Tyr 
        595                 600                 605             


Ser Val Leu Ile Arg Glu Gly Leu Thr Cys Pro Val Gly Ile Ala Leu 
    610                 615                 620                 


Thr Pro Lys Gly Gln Leu Leu Val Leu Asp Cys Trp Asp His Cys Ile 
625                 630                 635                 640 


Lys Ile Tyr Ser Tyr His Leu Arg Arg Tyr Ser Thr Pro 
                645                 650             


<210>  131
<211>  710
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BARDET-BIEDL SYNDROME 12 (BBS12) <Accession No.: AAH55426.1>

<400>  131

Met Val Met Ala Cys Arg Val Val Asn Lys Arg Arg His Met Gly Leu 
1               5                   10                  15      


Gln Gln Leu Ser Ser Phe Ala Glu Thr Gly Arg Thr Phe Leu Gly Pro 
            20                  25                  30          


Leu Lys Ser Ser Lys Phe Ile Ile Asp Glu Glu Cys His Glu Ser Val 
        35                  40                  45              


Leu Ile Ser Ser Thr Val Arg Leu Leu Glu Ser Leu Asp Leu Thr Ser 
    50                  55                  60                  


Ala Val Gly Gln Leu Leu Asn Glu Ala Val Gln Ala Gln Asn Asn Thr 
65                  70                  75                  80  


Tyr Arg Thr Gly Ile Ser Thr Leu Leu Phe Leu Val Gly Ala Trp Ser 
                85                  90                  95      


Ser Ala Val Glu Glu Cys Leu His Leu Gly Val Pro Ile Ser Ile Ile 
            100                 105                 110         


Val Ser Val Met Ser Glu Gly Leu Asn Phe Cys Ser Glu Glu Val Val 
        115                 120                 125             


Ser Leu His Val Pro Val His Asn Ile Phe Asp Cys Met Asp Ser Thr 
    130                 135                 140                 


Lys Thr Phe Ser Gln Leu Glu Thr Phe Ser Val Ser Leu Cys Pro Phe 
145                 150                 155                 160 


Leu Gln Val Pro Ser Asp Thr Asp Leu Ile Glu Glu Leu His Gly Leu 
                165                 170                 175     


Lys Asp Val Ala Ser Gln Thr Leu Thr Ile Ser Asn Leu Ser Gly Arg 
            180                 185                 190         


Pro Leu Arg Ser Tyr Glu Leu Phe Lys Pro Gln Thr Lys Val Glu Ala 
        195                 200                 205             


Asp Asn Asn Thr Ser Arg Thr Leu Lys Asn Ser Leu Leu Ala Asp Thr 
    210                 215                 220                 


Cys Cys Arg Gln Ser Ile Leu Ile His Ser Arg His Phe Asn Arg Thr 
225                 230                 235                 240 


Asp Asn Thr Glu Gly Val Ser Lys Pro Asp Gly Phe Gln Glu His Val 
                245                 250                 255     


Thr Ala Thr His Lys Thr Tyr Arg Cys Asn Asp Leu Val Glu Leu Ala 
            260                 265                 270         


Val Gly Leu Ser His Gly Asp His Ser Ser Met Lys Leu Val Glu Glu 
        275                 280                 285             


Ala Val Gln Leu Gln Tyr Gln Asn Ala Cys Val Gln Gln Gly Asn Cys 
    290                 295                 300                 


Thr Lys Pro Phe Met Phe Asp Ile Ser Arg Ile Phe Thr Cys Cys Leu 
305                 310                 315                 320 


Pro Gly Leu Pro Glu Thr Ser Ser Cys Val Cys Pro Gly Tyr Ile Thr 
                325                 330                 335     


Val Val Ser Val Ser Asn Asn Pro Val Ile Lys Glu Leu Gln Asn Gln 
            340                 345                 350         


Pro Val Arg Ile Val Leu Ile Glu Gly Asp Leu Thr Glu Asn Tyr Arg 
        355                 360                 365             


His Leu Gly Phe Asn Lys Ser Ala Asn Ile Lys Thr Val Leu Asp Ser 
    370                 375                 380                 


Met Gln Leu Gln Glu Asp Ser Ser Glu Glu Leu Trp Ala Asn His Val 
385                 390                 395                 400 


Leu Gln Val Leu Ile Gln Phe Lys Val Asn Leu Val Leu Val Gln Gly 
                405                 410                 415     


Asn Val Ser Glu Arg Leu Ile Glu Lys Cys Ile Asn Ser Lys Arg Leu 
            420                 425                 430         


Val Ile Gly Ser Val Asn Gly Ser Val Met Gln Ala Phe Ala Glu Ala 
        435                 440                 445             


Ala Gly Ala Val Gln Val Ala Tyr Ile Thr Gln Val Asn Glu Asp Cys 
    450                 455                 460                 


Val Gly Asn Gly Val Cys Val Thr Phe Trp Arg Ser Ser Pro Leu Asp 
465                 470                 475                 480 


Val Val Asp Arg Asn Asn Arg Ile Ala Ile Leu Leu Lys Thr Glu Gly 
                485                 490                 495     


Ile Asn Leu Val Thr Ala Val Leu Thr Asn Pro Val Thr Ala Gln Met 
            500                 505                 510         


Gln Ile Lys Glu Asp Arg Phe Trp Thr Cys Ala Tyr Arg Leu Tyr Tyr 
        515                 520                 525             


Ala Leu Lys Glu Glu Lys Val Phe Leu Gly Gly Gly Ala Val Glu Phe 
    530                 535                 540                 


Leu Cys Leu Ser Cys Leu His Ile Leu Ala Glu Gln Ser Leu Lys Lys 
545                 550                 555                 560 


Glu Asn His Ala Cys Ser Gly Trp Leu His Asn Thr Ser Ser Trp Leu 
                565                 570                 575     


Ala Ser Ser Leu Ala Ile Tyr Arg Pro Thr Val Leu Lys Phe Leu Ala 
            580                 585                 590         


Asn Gly Trp Gln Lys Tyr Leu Ser Thr Leu Leu Tyr Asn Thr Ala Asn 
        595                 600                 605             


Tyr Ser Ser Glu Phe Glu Val Ser Thr Tyr Ile Gln His His Leu Gln 
    610                 615                 620                 


Asn Ala Thr Asp Ser Gly Ser Pro Ser Ser Tyr Ile Leu Asn Glu Tyr 
625                 630                 635                 640 


Ser Lys Leu Asn Ser Arg Ile Phe Asn Ser Asp Ile Ser Asn Lys Leu 
                645                 650                 655     


Glu Gln Ile Pro Arg Val Tyr Asp Val Val Thr Pro Lys Ile Glu Ala 
            660                 665                 670         


Trp Arg Arg Ala Leu Asp Leu Val Leu Leu Val Leu Gln Thr Asp Ser 
        675                 680                 685             


Glu Ile Ile Thr Gly His Gly His Thr Gln Ile Asn Ser Gln Glu Leu 
    690                 695                 700                 


Thr Gly Phe Leu Phe Leu 
705                 710 


<210>  132
<211>  559
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MKS TRANSITION ZONE COMPLEX SUBUNIT 1 (MKS1)  
<Accession No.: NP_060247.2>

<400>  132

Met Ala Glu Thr Val Trp Ser Thr Asp Thr Gly Glu Ala Val Tyr Arg 
1               5                   10                  15      


Ser Arg Asp Pro Val Arg Asn Leu Arg Leu Arg Val His Leu Gln Arg 
            20                  25                  30          


Ile Thr Ser Ser Asn Phe Leu His Tyr Gln Pro Ala Ala Glu Leu Gly 
        35                  40                  45              


Lys Asp Leu Ile Asp Leu Ala Thr Phe Arg Pro Gln Pro Thr Ala Ser 
    50                  55                  60                  


Gly His Arg Pro Glu Glu Asp Glu Glu Glu Glu Ile Val Ile Gly Trp 
65                  70                  75                  80  


Gln Glu Lys Leu Phe Ser Gln Phe Glu Val Asp Leu Tyr Gln Asn Glu 
                85                  90                  95      


Thr Ala Cys Gln Ser Pro Leu Asp Tyr Gln Tyr Arg Gln Glu Ile Leu 
            100                 105                 110         


Lys Leu Glu Asn Ser Gly Gly Lys Lys Asn Arg Arg Ile Phe Thr Tyr 
        115                 120                 125             


Thr Asp Ser Asp Arg Tyr Thr Asn Leu Glu Glu His Cys Gln Arg Met 
    130                 135                 140                 


Thr Thr Ala Ala Ser Glu Val Pro Ser Phe Leu Val Glu Arg Met Ala 
145                 150                 155                 160 


Asn Val Arg Arg Arg Arg Gln Asp Arg Arg Gly Met Glu Gly Gly Ile 
                165                 170                 175     


Leu Lys Ser Arg Ile Val Thr Trp Glu Pro Ser Glu Glu Phe Val Arg 
            180                 185                 190         


Asn Asn His Val Ile Asn Thr Pro Leu Gln Thr Met His Ile Met Ala 
        195                 200                 205             


Asp Leu Gly Pro Tyr Lys Lys Leu Gly Tyr Lys Lys Tyr Glu His Val 
    210                 215                 220                 


Leu Cys Thr Leu Lys Val Asp Ser Asn Gly Val Ile Thr Val Lys Pro 
225                 230                 235                 240 


Asp Phe Thr Gly Leu Lys Gly Pro Tyr Arg Ile Glu Thr Glu Gly Glu 
                245                 250                 255     


Lys Gln Glu Leu Trp Lys Tyr Thr Ile Asp Asn Val Ser Pro His Ala 
            260                 265                 270         


Gln Pro Glu Glu Glu Glu Arg Glu Arg Arg Val Phe Lys Asp Leu Tyr 
        275                 280                 285             


Gly Arg His Lys Glu Tyr Leu Ser Ser Leu Val Gly Thr Asp Phe Glu 
    290                 295                 300                 


Met Thr Val Pro Gly Ala Leu Arg Leu Phe Val Asn Gly Glu Val Val 
305                 310                 315                 320 


Ser Ala Gln Gly Tyr Glu Tyr Asp Asn Leu Tyr Val His Phe Phe Val 
                325                 330                 335     


Glu Leu Pro Thr Ala His Trp Ser Ser Pro Ala Phe Gln Gln Leu Ser 
            340                 345                 350         


Gly Val Thr Gln Thr Cys Thr Thr Lys Ser Leu Ala Met Asp Lys Val 
        355                 360                 365             


Ala His Phe Ser Tyr Pro Phe Thr Phe Glu Ala Phe Phe Leu His Glu 
    370                 375                 380                 


Asp Glu Ser Ser Asp Ala Leu Pro Glu Trp Pro Val Leu Tyr Cys Glu 
385                 390                 395                 400 


Val Leu Ser Leu Asp Phe Trp Gln Arg Tyr Arg Val Glu Gly Tyr Gly 
                405                 410                 415     


Ala Val Val Leu Pro Ala Thr Pro Gly Ser His Thr Leu Thr Val Ser 
            420                 425                 430         


Thr Trp Arg Pro Val Glu Leu Gly Thr Val Ala Glu Leu Arg Arg Phe 
        435                 440                 445             


Phe Ile Gly Gly Ser Leu Glu Leu Glu Asp Leu Ser Tyr Val Arg Ile 
    450                 455                 460                 


Pro Gly Ser Phe Lys Gly Glu Arg Leu Ser Arg Phe Gly Leu Arg Thr 
465                 470                 475                 480 


Glu Thr Thr Gly Thr Val Thr Phe Arg Leu His Cys Leu Gln Gln Ser 
                485                 490                 495     


Arg Ala Phe Met Glu Ser Ser Ser Leu Gln Lys Arg Met Arg Ser Val 
            500                 505                 510         


Leu Asp Arg Leu Glu Gly Phe Ser Gln Gln Ser Ser Ile His Asn Val 
        515                 520                 525             


Leu Glu Ala Phe Arg Arg Ala Arg Arg Arg Met Gln Glu Ala Arg Glu 
    530                 535                 540                 


Ser Leu Pro Gln Asp Leu Val Ser Pro Ser Gly Thr Leu Val Ser 
545                 550                 555                 


<210>  133
<211>  587
<212>  PRT
<213>  Homo sapiens

<220>
<223>  WD REPEAT CONTAINING PLANAR CELL POLARITY EFFECTOR (WDPCP),
 HOMOLOG ISOFORM 1 <Accession No.: NP_001036157.1>

<400>  133

Met Phe Ser Ser Leu His Ser Ala Leu Leu Thr Asp Ser Phe Ile Ile 
1               5                   10                  15      


Leu Ser Phe Leu Ala Gln Asn Lys Leu Cys Phe Ile Gln Phe Thr Lys 
            20                  25                  30          


Lys Met Glu Ser Ser Asp Val Asn Lys Arg Leu Glu Lys Leu Ser Ala 
        35                  40                  45              


Leu Asp Tyr Lys Ile Phe Tyr Tyr Glu Ile Pro Gly Pro Ile Asn Lys 
    50                  55                  60                  


Thr Thr Glu Arg His Leu Ala Ile Asn Cys Val His Asp Arg Val Val 
65                  70                  75                  80  


Cys Trp Trp Pro Leu Val Asn Asp Asp Ala Trp Pro Trp Ala Pro Ile 
                85                  90                  95      


Ser Ser Glu Lys Asp Arg Ala Asn Leu Leu Leu Leu Gly Tyr Ala Gln 
            100                 105                 110         


Gly Arg Leu Glu Val Leu Ser Ser Val Arg Thr Glu Trp Asp Pro Leu 
        115                 120                 125             


Asp Val Arg Phe Gly Thr Lys Gln Pro Tyr Gln Val Phe Thr Val Glu 
    130                 135                 140                 


His Ser Val Ser Val Asp Lys Glu Pro Met Ala Asp Ser Cys Ile Tyr 
145                 150                 155                 160 


Glu Cys Ile Arg Asn Lys Ile Gln Cys Val Ser Val Thr Arg Ile Pro 
                165                 170                 175     


Leu Lys Ser Lys Ala Ile Ser Cys Cys Arg Asn Val Thr Glu Asp Lys 
            180                 185                 190         


Leu Ile Leu Gly Cys Glu Asp Ser Ser Leu Ile Leu Tyr Glu Thr His 
        195                 200                 205             


Arg Arg Val Thr Leu Leu Ala Gln Thr Glu Leu Leu Pro Ser Leu Ile 
    210                 215                 220                 


Ser Cys His Pro Ser Gly Ala Ile Leu Leu Val Gly Ser Asn Gln Gly 
225                 230                 235                 240 


Glu Leu Gln Ile Phe Asp Met Ala Leu Ser Pro Ile Asn Ile Gln Leu 
                245                 250                 255     


Leu Ala Glu Asp Arg Leu Pro Arg Glu Thr Leu Gln Phe Ser Lys Leu 
            260                 265                 270         


Phe Asp Ala Ser Ser Ser Leu Val Gln Met Gln Trp Ile Ala Pro Gln 
        275                 280                 285             


Val Val Ser Gln Lys Gly Glu Gly Ser Asp Ile Tyr Asp Leu Leu Phe 
    290                 295                 300                 


Leu Arg Phe Glu Arg Gly Pro Leu Gly Val Leu Leu Phe Lys Leu Gly 
305                 310                 315                 320 


Val Phe Thr Arg Gly Gln Leu Gly Leu Ile Asp Ile Ile Phe Gln Tyr 
                325                 330                 335     


Ile His Cys Asp Glu Ile Tyr Glu Ala Ile Asn Ile Leu Ser Ser Met 
            340                 345                 350         


Asn Trp Asp Thr Leu Gly His Gln Cys Phe Ile Ser Met Ser Ala Ile 
        355                 360                 365             


Val Asn His Leu Leu Arg Gln Lys Leu Thr Pro Glu Arg Glu Ala Gln 
    370                 375                 380                 


Leu Glu Thr Ser Leu Gly Thr Phe Tyr Ala Pro Thr Arg Pro Leu Leu 
385                 390                 395                 400 


Asp Ser Thr Ile Leu Glu Tyr Arg Asp Gln Ile Ser Lys Tyr Ala Arg 
                405                 410                 415     


Arg Phe Phe His His Leu Leu Arg Tyr Gln Arg Phe Glu Lys Ala Phe 
            420                 425                 430         


Leu Leu Ala Val Asp Val Gly Ala Arg Asp Leu Phe Met Asp Ile His 
        435                 440                 445             


Tyr Leu Ala Leu Asp Lys Gly Glu Leu Ala Leu Ala Glu Val Ala Arg 
    450                 455                 460                 


Lys Arg Ala Ser Asp Ile Asp Ala Glu Ser Ile Thr Ser Gly Val Glu 
465                 470                 475                 480 


Leu Leu Gly Pro Leu Asp Arg Gly Asp Met Leu Asn Glu Ala Phe Ile 
                485                 490                 495     


Gly Leu Ser Leu Ala Pro Gln Gly Glu Asp Ser Phe Pro Asp Asn Leu 
            500                 505                 510         


Pro Pro Ser Cys Pro Thr His Arg His Ile Leu Gln Gln Arg Ile Leu 
        515                 520                 525             


Asn Gly Ser Ser Asn Arg Gln Ile Ile Asp Arg Arg Asn Glu Leu Glu 
    530                 535                 540                 


Lys Asp Ile Cys Ser Gly Phe Leu Met Thr Asn Thr Cys Asn Ala Glu 
545                 550                 555                 560 


Asp Gly Glu Leu Arg Glu Asp Gly Arg Glu Gln Glu Ile Arg Asp Gly 
                565                 570                 575     


Gly Ser Leu Lys Met Ile His Phe Gly Leu Val 
            580                 585         


<210>  134
<211>  746
<212>  PRT
<213>  Homo sapiens

<220>
<223>  WD REPEAT CONTAINING PLANAR CELL POLARITY EFFECTOR (WDPCP), 
HOMOLOG ISOFORM 2 <Accession No.: NP_056994.3>

<400>  134

Met Arg Arg Glu Phe Cys Trp Asp Ala Tyr Ser Lys Ala Ala Gly Ser 
1               5                   10                  15      


Arg Ala Ser Ser Pro Leu Pro Arg Gln Asp Arg Asp Ser Phe Cys His 
            20                  25                  30          


Gln Met Ser Phe Cys Leu Thr Glu Leu His Leu Trp Ser Leu Lys Asn 
        35                  40                  45              


Thr Leu His Ile Ala Asp Arg Asp Ile Gly Ile Tyr Gln Tyr Tyr Asp 
    50                  55                  60                  


Lys Lys Asp Pro Pro Ala Thr Glu His Gly Asn Leu Glu Lys Lys Gln 
65                  70                  75                  80  


Lys Leu Ala Glu Ser Arg Asp Tyr Pro Trp Thr Leu Lys Asn Arg Arg 
                85                  90                  95      


Pro Glu Lys Leu Arg Asp Ser Leu Lys Glu Leu Glu Glu Leu Met Gln 
            100                 105                 110         


Asn Ser Arg Cys Val Leu Ser Lys Trp Lys Asn Lys Tyr Val Cys Gln 
        115                 120                 125             


Leu Leu Phe Gly Ser Gly Val Leu Val Ser Leu Ser Leu Ser Gly Pro 
    130                 135                 140                 


Gln Leu Glu Lys Val Val Ile Asp Arg Ser Leu Val Gly Lys Leu Ile 
145                 150                 155                 160 


Ser Asp Thr Ile Ser Asp Ala Leu Leu Thr Asp Ser Phe Ile Ile Leu 
                165                 170                 175     


Ser Phe Leu Ala Gln Asn Lys Leu Cys Phe Ile Gln Phe Thr Lys Lys 
            180                 185                 190         


Met Glu Ser Ser Asp Val Asn Lys Arg Leu Glu Lys Leu Ser Ala Leu 
        195                 200                 205             


Asp Tyr Lys Ile Phe Tyr Tyr Glu Ile Pro Gly Pro Ile Asn Lys Thr 
    210                 215                 220                 


Thr Glu Arg His Leu Ala Ile Asn Cys Val His Asp Arg Val Val Cys 
225                 230                 235                 240 


Trp Trp Pro Leu Val Asn Asp Asp Ala Trp Pro Trp Ala Pro Ile Ser 
                245                 250                 255     


Ser Glu Lys Asp Arg Ala Asn Leu Leu Leu Leu Gly Tyr Ala Gln Gly 
            260                 265                 270         


Arg Leu Glu Val Leu Ser Ser Val Arg Thr Glu Trp Asp Pro Leu Asp 
        275                 280                 285             


Val Arg Phe Gly Thr Lys Gln Pro Tyr Gln Val Phe Thr Val Glu His 
    290                 295                 300                 


Ser Val Ser Val Asp Lys Glu Pro Met Ala Asp Ser Cys Ile Tyr Glu 
305                 310                 315                 320 


Cys Ile Arg Asn Lys Ile Gln Cys Val Ser Val Thr Arg Ile Pro Leu 
                325                 330                 335     


Lys Ser Lys Ala Ile Ser Cys Cys Arg Asn Val Thr Glu Asp Lys Leu 
            340                 345                 350         


Ile Leu Gly Cys Glu Asp Ser Ser Leu Ile Leu Tyr Glu Thr His Arg 
        355                 360                 365             


Arg Val Thr Leu Leu Ala Gln Thr Glu Leu Leu Pro Ser Leu Ile Ser 
    370                 375                 380                 


Cys His Pro Ser Gly Ala Ile Leu Leu Val Gly Ser Asn Gln Gly Glu 
385                 390                 395                 400 


Leu Gln Ile Phe Asp Met Ala Leu Ser Pro Ile Asn Ile Gln Leu Leu 
                405                 410                 415     


Ala Glu Asp Arg Leu Pro Arg Glu Thr Leu Gln Phe Ser Lys Leu Phe 
            420                 425                 430         


Asp Ala Ser Ser Ser Leu Val Gln Met Gln Trp Ile Ala Pro Gln Val 
        435                 440                 445             


Val Ser Gln Lys Gly Glu Gly Ser Asp Ile Tyr Asp Leu Leu Phe Leu 
    450                 455                 460                 


Arg Phe Glu Arg Gly Pro Leu Gly Val Leu Leu Phe Lys Leu Gly Val 
465                 470                 475                 480 


Phe Thr Arg Gly Gln Leu Gly Leu Ile Asp Ile Ile Phe Gln Tyr Ile 
                485                 490                 495     


His Cys Asp Glu Ile Tyr Glu Ala Ile Asn Ile Leu Ser Ser Met Asn 
            500                 505                 510         


Trp Asp Thr Leu Gly His Gln Cys Phe Ile Ser Met Ser Ala Ile Val 
        515                 520                 525             


Asn His Leu Leu Arg Gln Lys Leu Thr Pro Glu Arg Glu Ala Gln Leu 
    530                 535                 540                 


Glu Thr Ser Leu Gly Thr Phe Tyr Ala Pro Thr Arg Pro Leu Leu Asp 
545                 550                 555                 560 


Ser Thr Ile Leu Glu Tyr Arg Asp Gln Ile Ser Lys Tyr Ala Arg Arg 
                565                 570                 575     


Phe Phe His His Leu Leu Arg Tyr Gln Arg Phe Glu Lys Ala Phe Leu 
            580                 585                 590         


Leu Ala Val Asp Val Gly Ala Arg Asp Leu Phe Met Asp Ile His Tyr 
        595                 600                 605             


Leu Ala Leu Asp Lys Gly Glu Leu Ala Leu Ala Glu Val Ala Arg Lys 
    610                 615                 620                 


Arg Ala Ser Asp Ile Asp Ala Glu Ser Ile Thr Ser Gly Val Glu Leu 
625                 630                 635                 640 


Leu Gly Pro Leu Asp Arg Gly Asp Met Leu Asn Glu Ala Phe Ile Gly 
                645                 650                 655     


Leu Ser Leu Ala Pro Gln Gly Glu Asp Ser Phe Pro Asp Asn Leu Pro 
            660                 665                 670         


Pro Ser Cys Pro Thr His Arg His Ile Leu Gln Gln Arg Ile Leu Asn 
        675                 680                 685             


Gly Ser Ser Asn Arg Gln Ile Ile Asp Arg Arg Asn Glu Leu Glu Lys 
    690                 695                 700                 


Asp Ile Cys Ser Gly Phe Leu Met Thr Asn Thr Cys Asn Ala Glu Asp 
705                 710                 715                 720 


Gly Glu Leu Arg Glu Asp Gly Arg Glu Gln Glu Ile Arg Asp Gly Gly 
                725                 730                 735     


Ser Leu Lys Met Ile His Phe Gly Leu Val 
            740                 745     


<210>  135
<211>  722
<212>  PRT
<213>  Homo sapiens

<220>
<223>  WD REPEAT CONTAINING PLANAR CELL POLARITY EFFECTOR (WDPCP), 
HOMOLOG ISOFORM 3 <Accession No.: NP_001340973.1>

<400>  135

Met Asp Arg Asp Ser Phe Cys His Gln Met Ser Phe Cys Leu Thr Glu 
1               5                   10                  15      


Leu His Leu Trp Ser Leu Lys Asn Thr Leu His Ile Ala Asp Arg Asp 
            20                  25                  30          


Ile Gly Ile Tyr Gln Tyr Tyr Asp Lys Lys Asp Pro Pro Ala Thr Glu 
        35                  40                  45              


His Gly Asn Leu Glu Lys Lys Gln Lys Leu Ala Glu Ser Arg Asp Tyr 
    50                  55                  60                  


Pro Trp Thr Leu Lys Asn Arg Arg Pro Glu Lys Leu Arg Asp Ser Leu 
65                  70                  75                  80  


Lys Glu Leu Glu Glu Leu Met Gln Asn Ser Arg Cys Val Leu Ser Lys 
                85                  90                  95      


Trp Lys Asn Lys Tyr Val Cys Gln Leu Leu Phe Gly Ser Gly Val Leu 
            100                 105                 110         


Val Ser Leu Ser Leu Ser Gly Pro Gln Leu Glu Lys Val Val Ile Asp 
        115                 120                 125             


Arg Ser Leu Val Gly Lys Leu Ile Ser Asp Thr Ile Ser Asp Ala Leu 
    130                 135                 140                 


Leu Thr Asp Ser Phe Ile Ile Leu Ser Phe Leu Ala Gln Asn Lys Leu 
145                 150                 155                 160 


Cys Phe Ile Gln Phe Thr Lys Lys Met Glu Ser Ser Asp Val Asn Lys 
                165                 170                 175     


Arg Leu Glu Lys Leu Ser Ala Leu Asp Tyr Lys Ile Phe Tyr Tyr Glu 
            180                 185                 190         


Ile Pro Gly Pro Ile Asn Lys Thr Thr Glu Arg His Leu Ala Ile Asn 
        195                 200                 205             


Cys Val His Asp Arg Val Val Cys Trp Trp Pro Leu Val Asn Asp Asp 
    210                 215                 220                 


Ala Trp Pro Trp Ala Pro Ile Ser Ser Glu Lys Asp Arg Ala Asn Leu 
225                 230                 235                 240 


Leu Leu Leu Gly Tyr Ala Gln Gly Arg Leu Glu Val Leu Ser Ser Val 
                245                 250                 255     


Arg Thr Glu Trp Asp Pro Leu Asp Val Arg Phe Gly Thr Lys Gln Pro 
            260                 265                 270         


Tyr Gln Val Phe Thr Val Glu His Ser Val Ser Val Asp Lys Glu Pro 
        275                 280                 285             


Met Ala Asp Ser Cys Ile Tyr Glu Cys Ile Arg Asn Lys Ile Gln Cys 
    290                 295                 300                 


Val Ser Val Thr Arg Ile Pro Leu Lys Ser Lys Ala Ile Ser Cys Cys 
305                 310                 315                 320 


Arg Asn Val Thr Glu Asp Lys Leu Ile Leu Gly Cys Glu Asp Ser Ser 
                325                 330                 335     


Leu Ile Leu Tyr Glu Thr His Arg Arg Val Thr Leu Leu Ala Gln Thr 
            340                 345                 350         


Glu Leu Leu Pro Ser Leu Ile Ser Cys His Pro Ser Gly Ala Ile Leu 
        355                 360                 365             


Leu Val Gly Ser Asn Gln Gly Glu Leu Gln Ile Phe Asp Met Ala Leu 
    370                 375                 380                 


Ser Pro Ile Asn Ile Gln Leu Leu Ala Glu Asp Arg Leu Pro Arg Glu 
385                 390                 395                 400 


Thr Leu Gln Phe Ser Lys Leu Phe Asp Ala Ser Ser Ser Leu Val Gln 
                405                 410                 415     


Met Gln Trp Ile Ala Pro Gln Val Val Ser Gln Lys Gly Glu Gly Ser 
            420                 425                 430         


Asp Ile Tyr Asp Leu Leu Phe Leu Arg Phe Glu Arg Gly Pro Leu Gly 
        435                 440                 445             


Val Leu Leu Phe Lys Leu Gly Val Phe Thr Arg Gly Gln Leu Gly Leu 
    450                 455                 460                 


Ile Asp Ile Ile Phe Gln Tyr Ile His Cys Asp Glu Ile Tyr Glu Ala 
465                 470                 475                 480 


Ile Asn Ile Leu Ser Ser Met Asn Trp Asp Thr Leu Gly His Gln Cys 
                485                 490                 495     


Phe Ile Ser Met Ser Ala Ile Val Asn His Leu Leu Arg Gln Lys Leu 
            500                 505                 510         


Thr Pro Glu Arg Glu Ala Gln Leu Glu Thr Ser Leu Gly Thr Phe Tyr 
        515                 520                 525             


Ala Pro Thr Arg Pro Leu Leu Asp Ser Thr Ile Leu Glu Tyr Arg Asp 
    530                 535                 540                 


Gln Ile Ser Lys Tyr Ala Arg Arg Phe Phe His His Leu Leu Arg Tyr 
545                 550                 555                 560 


Gln Arg Phe Glu Lys Ala Phe Leu Leu Ala Val Asp Val Gly Ala Arg 
                565                 570                 575     


Asp Leu Phe Met Asp Ile His Tyr Leu Ala Leu Asp Lys Gly Glu Leu 
            580                 585                 590         


Ala Leu Ala Glu Val Ala Arg Lys Arg Ala Ser Asp Ile Asp Ala Glu 
        595                 600                 605             


Ser Ile Thr Ser Gly Val Glu Leu Leu Gly Pro Leu Asp Arg Gly Asp 
    610                 615                 620                 


Met Leu Asn Glu Ala Phe Ile Gly Leu Ser Leu Ala Pro Gln Gly Glu 
625                 630                 635                 640 


Asp Ser Phe Pro Asp Asn Leu Pro Pro Ser Cys Pro Thr His Arg His 
                645                 650                 655     


Ile Leu Gln Gln Arg Ile Leu Asn Gly Ser Ser Asn Arg Gln Ile Ile 
            660                 665                 670         


Asp Arg Arg Asn Glu Leu Glu Lys Asp Ile Cys Ser Gly Phe Leu Met 
        675                 680                 685             


Thr Asn Thr Cys Asn Ala Glu Asp Gly Glu Leu Arg Glu Asp Gly Arg 
    690                 695                 700                 


Glu Gln Glu Ile Arg Asp Gly Gly Ser Leu Lys Met Ile His Phe Gly 
705                 710                 715                 720 


Leu Val 
        


<210>  136
<211>  649
<212>  PRT
<213>  Homo sapiens

<220>
<223>  WD REPEAT CONTAINING PLANAR CELL POLARITY EFFECTOR (WDPCP), 
HOMOLOG ISOFORM 4 <Accession No.: NP_001340974.1>

<400>  136

Met Arg Arg Glu Phe Cys Trp Asp Ala Tyr Ser Lys Ala Ala Gly Ser 
1               5                   10                  15      


Arg Ala Ser Ser Pro Leu Pro Arg Gln Asp Arg Asp Ser Phe Cys His 
            20                  25                  30          


Gln Met Ser Phe Cys Leu Thr Glu Leu His Leu Trp Ser Leu Lys Asn 
        35                  40                  45              


Thr Leu His Ile Ala Asp Arg Asp Ile Gly Ile Tyr Gln Tyr Tyr Asp 
    50                  55                  60                  


Lys Lys Asp Pro Pro Ala Thr Glu His Gly Asn Leu Glu Lys Lys Gln 
65                  70                  75                  80  


Lys Leu Ala Glu Ser Arg Asp Tyr Pro Trp Thr Leu Lys Asn Arg Arg 
                85                  90                  95      


Pro Glu Lys Leu Arg Asp Ser Leu Lys Glu Leu Glu Glu Leu Met Gln 
            100                 105                 110         


Asn Ser Arg Cys Val Leu Ser Lys Trp Lys Asn Lys Tyr Val Cys Gln 
        115                 120                 125             


Leu Leu Phe Gly Ser Gly Val Leu Val Ser Leu Ser Leu Ser Gly Pro 
    130                 135                 140                 


Gln Leu Glu Lys Val Val Ile Asp Arg Ser Leu Val Gly Lys Leu Ile 
145                 150                 155                 160 


Ser Asp Thr Ile Ser Asp Ala Leu Leu Thr Asp Ser Phe Ile Ile Leu 
                165                 170                 175     


Ser Phe Leu Ala Gln Asn Lys Leu Cys Phe Ile Gln Phe Thr Lys Lys 
            180                 185                 190         


Met Glu Ser Ser Asp Val Asn Lys Arg Leu Glu Lys Leu Ser Ala Leu 
        195                 200                 205             


Asp Tyr Lys Ile Phe Tyr Tyr Glu Ile Pro Gly Pro Ile Asn Lys Thr 
    210                 215                 220                 


Thr Glu Arg His Leu Ala Ile Asn Cys Val His Asp Arg Val Val Cys 
225                 230                 235                 240 


Trp Trp Pro Leu Val Asn Asp Asp Ala Trp Pro Trp Ala Pro Ile Ser 
                245                 250                 255     


Ser Glu Lys Asp Arg Ala Asn Leu Leu Leu Leu Gly Tyr Ala Gln Gly 
            260                 265                 270         


Arg Leu Glu Val Leu Ser Ser Val Arg Thr Glu Trp Asp Pro Leu Asp 
        275                 280                 285             


Val Arg Phe Gly Thr Lys Gln Pro Tyr Gln Val Phe Thr Val Glu His 
    290                 295                 300                 


Ser Val Ser Val Asp Lys Glu Pro Met Ala Asp Ser Cys Ile Tyr Glu 
305                 310                 315                 320 


Cys Ile Arg Asn Lys Ile Gln Cys Val Ser Val Thr Arg Ile Pro Leu 
                325                 330                 335     


Lys Ser Lys Ala Ile Ser Cys Cys Arg Asn Val Thr Glu Asp Lys Leu 
            340                 345                 350         


Ile Leu Gly Cys Glu Asp Ser Ser Leu Ile Leu Tyr Glu Thr His Arg 
        355                 360                 365             


Arg Val Thr Leu Leu Ala Gln Thr Glu Leu Leu Pro Ser Leu Ile Ser 
    370                 375                 380                 


Cys His Pro Ser Gly Ala Ile Leu Leu Val Gly Ser Asn Gln Gly Glu 
385                 390                 395                 400 


Leu Gln Ile Phe Asp Met Ala Leu Ser Pro Ile Asn Ile Gln Leu Leu 
                405                 410                 415     


Ala Glu Asp Arg Leu Pro Arg Glu Thr Leu Gln Phe Ser Lys Leu Phe 
            420                 425                 430         


Asp Ala Ser Ser Ser Leu Val Gln Met Gln Trp Ile Ala Pro Gln Val 
        435                 440                 445             


Val Ser Gln Lys Gly Glu Gly Ser Asp Ile Tyr Asp Leu Leu Phe Leu 
    450                 455                 460                 


Arg Phe Glu Arg Gly Pro Leu Gly Val Leu Leu Phe Lys Leu Gly Val 
465                 470                 475                 480 


Phe Thr Arg Gly Gln Leu Gly Leu Ile Asp Ile Ile Phe Gln Tyr Ile 
                485                 490                 495     


His Cys Asp Glu Ile Tyr Glu Ala Ile Asn Ile Leu Ser Ser Met Asn 
            500                 505                 510         


Trp Asp Thr Leu Gly His Gln Cys Phe Ile Ser Met Ser Ala Ile Val 
        515                 520                 525             


Asn His Leu Leu Arg Gln Lys Leu Thr Pro Glu Arg Glu Ala Gln Leu 
    530                 535                 540                 


Glu Thr Ser Leu Gly Thr Phe Tyr Ala Pro Thr Arg Pro Leu Leu Asp 
545                 550                 555                 560 


Ser Thr Ile Leu Glu Tyr Arg Asp Gln Ile Ser Lys Tyr Ala Arg Arg 
                565                 570                 575     


Phe Phe His His Leu Leu Arg Trp Ser Leu Ala Leu Ser Pro Arg Leu 
            580                 585                 590         


Glu Cys Ser Asp Val Ile Ala Val His Cys His Leu His Leu Leu Gly 
        595                 600                 605             


Ser Ser Asp Ser Ser Ala Ser Ala Ser Arg Val Ala Gly Thr Thr Gly 
    610                 615                 620                 


Met Cys His His Thr Gln Leu Ile Phe Val Val Phe Ser Arg Asp Gly 
625                 630                 635                 640 


Ile Ser Pro Cys Trp Pro Gly Trp Ser 
                645                 


<210>  137
<211>  713
<212>  PRT
<213>  Homo sapiens

<220>
<223>  SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 (SDCCAG8) 
 <Accession No.: Q86SQ7.1>

<400>  137

Met Ala Lys Ser Pro Glu Asn Ser Thr Leu Glu Glu Ile Leu Gly Gln 
1               5                   10                  15      


Tyr Gln Arg Ser Leu Arg Glu His Ala Ser Arg Ser Ile His Gln Leu 
            20                  25                  30          


Thr Cys Ala Leu Lys Glu Gly Asp Val Thr Ile Gly Glu Asp Ala Pro 
        35                  40                  45              


Asn Leu Ser Phe Ser Thr Ser Val Gly Asn Glu Asp Ala Arg Thr Ala 
    50                  55                  60                  


Trp Pro Glu Leu Gln Gln Ser His Ala Val Asn Gln Leu Lys Asp Leu 
65                  70                  75                  80  


Leu Arg Gln Gln Ala Asp Lys Glu Ser Glu Val Ser Pro Ser Arg Arg 
                85                  90                  95      


Arg Lys Met Ser Pro Leu Arg Ser Leu Glu His Glu Glu Thr Asn Met 
            100                 105                 110         


Pro Thr Met His Asp Leu Val His Thr Ile Asn Asp Gln Ser Gln Tyr 
        115                 120                 125             


Ile His His Leu Glu Ala Glu Val Lys Phe Cys Lys Glu Glu Leu Ser 
    130                 135                 140                 


Gly Met Lys Asn Lys Ile Gln Val Val Val Leu Glu Asn Glu Gly Leu 
145                 150                 155                 160 


Gln Gln Gln Leu Lys Ser Gln Arg Gln Glu Glu Thr Leu Arg Glu Gln 
                165                 170                 175     


Thr Leu Leu Asp Ala Ser Gly Asn Met His Asn Ser Trp Ile Thr Thr 
            180                 185                 190         


Gly Glu Asp Ser Gly Val Gly Glu Thr Ser Lys Arg Pro Phe Ser His 
        195                 200                 205             


Asp Asn Ala Asp Phe Gly Lys Ala Ala Ser Ala Gly Glu Gln Leu Glu 
    210                 215                 220                 


Leu Glu Lys Leu Lys Leu Thr Tyr Glu Glu Lys Cys Glu Ile Glu Glu 
225                 230                 235                 240 


Ser Gln Leu Lys Phe Leu Arg Asn Asp Leu Ala Glu Tyr Gln Arg Thr 
                245                 250                 255     


Cys Glu Asp Leu Lys Glu Gln Leu Lys His Lys Glu Phe Leu Leu Ala 
            260                 265                 270         


Ala Asn Thr Cys Asn Arg Val Gly Gly Leu Cys Leu Lys Cys Ala Gln 
        275                 280                 285             


His Glu Ala Val Leu Ser Gln Thr His Thr Asn Val His Met Gln Thr 
    290                 295                 300                 


Ile Glu Arg Leu Val Lys Glu Arg Asp Asp Leu Met Ser Ala Leu Val 
305                 310                 315                 320 


Ser Val Arg Ser Ser Leu Ala Asp Thr Gln Gln Arg Glu Ala Ser Ala 
                325                 330                 335     


Tyr Glu Gln Val Lys Gln Val Leu Gln Ile Ser Glu Glu Ala Asn Phe 
            340                 345                 350         


Glu Lys Thr Lys Ala Leu Ile Gln Cys Asp Gln Leu Arg Lys Glu Leu 
        355                 360                 365             


Glu Arg Gln Ala Glu Arg Leu Glu Lys Glu Leu Ala Ser Gln Gln Glu 
    370                 375                 380                 


Lys Arg Ala Ile Glu Lys Asp Met Met Lys Lys Glu Ile Thr Lys Glu 
385                 390                 395                 400 


Arg Glu Tyr Met Gly Ser Lys Met Leu Ile Leu Ser Gln Asn Ile Ala 
                405                 410                 415     


Gln Leu Glu Ala Gln Val Glu Lys Val Thr Lys Glu Lys Ile Ser Ala 
            420                 425                 430         


Ile Asn Gln Leu Glu Glu Ile Gln Ser Gln Leu Ala Ser Arg Glu Met 
        435                 440                 445             


Asp Val Thr Lys Val Cys Gly Glu Met Arg Tyr Gln Leu Asn Lys Thr 
    450                 455                 460                 


Asn Met Glu Lys Asp Glu Ala Glu Lys Glu His Arg Glu Phe Arg Ala 
465                 470                 475                 480 


Lys Thr Asn Arg Asp Leu Glu Ile Lys Asp Gln Glu Ile Glu Lys Leu 
                485                 490                 495     


Arg Ile Glu Leu Asp Glu Ser Lys Gln His Leu Glu Gln Glu Gln Gln 
            500                 505                 510         


Lys Ala Ala Leu Ala Arg Glu Glu Cys Leu Arg Leu Thr Glu Leu Leu 
        515                 520                 525             


Gly Glu Ser Glu His Gln Leu His Leu Thr Arg Gln Glu Lys Asp Ser 
    530                 535                 540                 


Ile Gln Gln Ser Phe Ser Lys Glu Ala Lys Ala Gln Ala Leu Gln Ala 
545                 550                 555                 560 


Gln Gln Arg Glu Gln Glu Leu Thr Gln Lys Ile Gln Gln Met Glu Ala 
                565                 570                 575     


Gln His Asp Lys Thr Glu Asn Glu Gln Tyr Leu Leu Leu Thr Ser Gln 
            580                 585                 590         


Asn Thr Phe Leu Thr Lys Leu Lys Glu Glu Cys Cys Thr Leu Ala Lys 
        595                 600                 605             


Lys Leu Glu Gln Ile Ser Gln Lys Thr Arg Ser Glu Ile Ala Gln Leu 
    610                 615                 620                 


Ser Gln Glu Lys Arg Tyr Thr Tyr Asp Lys Leu Gly Lys Leu Gln Arg 
625                 630                 635                 640 


Arg Asn Glu Glu Leu Glu Glu Gln Cys Val Gln His Gly Arg Val His 
                645                 650                 655     


Glu Thr Met Lys Gln Arg Leu Arg Gln Leu Asp Lys His Ser Gln Ala 
            660                 665                 670         


Thr Ala Gln Gln Leu Val Gln Leu Leu Ser Lys Gln Asn Gln Leu Leu 
        675                 680                 685             


Leu Glu Arg Gln Ser Leu Ser Glu Glu Val Asp Arg Leu Arg Thr Gln 
    690                 695                 700                 


Leu Pro Ser Met Pro Gln Ser Asp Cys 
705                 710             


<210>  138
<211>  299
<212>  PRT
<213>  Homo sapiens

<220>
<223>  LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE 1 (LZTFL1)  
<Accession No.: CAB95836.1>

<400>  138

Met Ala Glu Leu Gly Leu Asn Glu His His Gln Asn Glu Val Ile Asn 
1               5                   10                  15      


Tyr Met Arg Phe Ala Arg Ser Lys Arg Gly Leu Arg Leu Lys Thr Val 
            20                  25                  30          


Asp Ser Cys Phe Gln Asp Leu Lys Glu Ser Arg Leu Val Glu Asp Thr 
        35                  40                  45              


Phe Thr Ile Asp Glu Val Ser Glu Val Leu Asn Gly Leu Gln Ala Val 
    50                  55                  60                  


Val His Ser Glu Val Glu Ser Glu Leu Ile Asn Thr Ala Tyr Thr Asn 
65                  70                  75                  80  


Val Leu Leu Leu Arg Gln Leu Phe Ala Gln Ala Glu Lys Trp Tyr Leu 
                85                  90                  95      


Lys Leu Gln Thr Asp Ile Ser Glu Leu Glu Asn Arg Glu Leu Leu Glu 
            100                 105                 110         


Gln Val Ala Glu Phe Glu Lys Ala Glu Ile Thr Ser Ser Asn Lys Lys 
        115                 120                 125             


Pro Ile Leu Asp Val Thr Lys Pro Lys Leu Ala Pro Leu Asn Glu Gly 
    130                 135                 140                 


Gly Thr Ala Glu Leu Leu Asn Lys Glu Ile Leu Arg Leu Gln Glu Glu 
145                 150                 155                 160 


Asn Glu Lys Leu Lys Ser Arg Leu Lys Thr Ile Glu Ile Gln Ala Thr 
                165                 170                 175     


Asn Ala Leu Asp Glu Lys Ser Lys Leu Glu Lys Ala Leu Gln Asp Leu 
            180                 185                 190         


Gln Leu Asp Gln Gly Asn Gln Lys Asp Phe Ile Lys Ala Gln Asp Leu 
        195                 200                 205             


Ser Asn Leu Glu Asn Thr Val Ala Ala Leu Lys Ser Glu Phe Gln Lys 
    210                 215                 220                 


Thr Leu Asn Asp Lys Thr Glu Asn Gln Lys Ser Leu Glu Glu Asn Leu 
225                 230                 235                 240 


Ala Thr Ala Lys His Asp Leu Leu Arg Val Gln Glu Gln Leu His Met 
                245                 250                 255     


Ala Glu Lys Glu Leu Glu Lys Lys Phe Gln Gln Thr Ala Ala Tyr Arg 
            260                 265                 270         


Asn Met Lys Glu Ile Leu Thr Lys Lys Asn Asp Gln Ile Lys Asp Leu 
        275                 280                 285             


Arg Lys Arg Leu Ala Gln Tyr Glu Pro Glu Asp 
    290                 295                 


<210>  139
<211>  103
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BBSOME INTERACTING PROTEIN 1 (BBIP1), ISOFORM 1 
<Accession No.: NP_001182233.1>

<400>  139

Met Leu Lys Ala Ala Ala Lys Arg Pro Glu Leu Ser Gly Leu Leu Lys 
1               5                   10                  15      


Phe Asn Asn Tyr Gly Ile Leu Ser Glu Ser Pro Leu Thr Ser Gln Arg 
            20                  25                  30          


Thr Thr Trp Leu Leu Tyr Gln Ser Pro Ser Phe Ile Pro Gly Phe Ala 
        35                  40                  45              


Tyr Pro Ser Arg Cys Leu Lys Thr Ile Gly Gly Val Tyr Lys Gln Ala 
    50                  55                  60                  


Arg Lys Lys His Tyr Ile Gln Gln Leu Arg Tyr Gly Arg Ser Glu Val 
65                  70                  75                  80  


Asn Val Pro Gly Ser Ser Ser Lys Ala Arg Ala Thr Val Cys Gly Arg 
                85                  90                  95      


Tyr Asn Asp Asn Gly Ala Val 
            100             


<210>  140
<211>  92
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BBSOME INTERACTING PROTEIN 1 (BBIP1), ISOFORM 2 <Accession 
No.: NP_001182234.1>

<400>  140

Met Leu Lys Ala Ala Ala Lys Arg Pro Glu Leu Ser Gly Lys Asn Thr 
1               5                   10                  15      


Ile Ser Asn Asn Ser Asp Met Ala Glu Val Lys Ser Met Phe Arg Glu 
            20                  25                  30          


Val Leu Pro Lys Gln Gly Pro Leu Phe Val Glu Asp Ile Met Thr Met 
        35                  40                  45              


Val Leu Cys Lys Pro Lys Leu Leu Pro Leu Lys Ser Leu Thr Leu Glu 
    50                  55                  60                  


Lys Leu Glu Lys Met His Gln Ala Ala Gln Asn Thr Ile Arg Gln Gln 
65                  70                  75                  80  


Glu Met Ala Glu Lys Asp Gln Arg Gln Ile Thr His 
                85                  90          


<210>  141
<211>  186
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTRAFLAGELLAR TRANSPORT 27 (IFT27), HOMOLOG ISOFORM 1 
<Accession No.: NP_001349932.1>

<400>  141

Met Val Lys Leu Ala Ala Lys Cys Ile Leu Ala Gly Asp Pro Ala Val 
1               5                   10                  15      


Gly Lys Thr Ala Leu Ala Gln Ile Phe Arg Ser Asp Gly Ala His Phe 
            20                  25                  30          


Gln Lys Ser Tyr Thr Leu Thr Thr Gly Met Asp Leu Val Val Lys Thr 
        35                  40                  45              


Val Pro Val Pro Asp Thr Gly Asp Ser Val Glu Leu Phe Ile Phe Asp 
    50                  55                  60                  


Ser Ala Gly Lys Glu Leu Phe Ser Glu Met Leu Asp Lys Leu Trp Glu 
65                  70                  75                  80  


Ser Pro Asn Val Leu Cys Leu Val Tyr Asp Val Thr Asn Glu Glu Ser 
                85                  90                  95      


Phe Asn Asn Cys Ser Lys Trp Leu Glu Lys Ala Arg Ser Gln Ala Pro 
            100                 105                 110         


Gly Ile Ser Leu Pro Gly Val Leu Val Gly Asn Lys Thr Asp Leu Ala 
        115                 120                 125             


Gly Arg Arg Ala Val Asp Ser Ala Glu Ala Arg Ala Trp Ala Leu Gly 
    130                 135                 140                 


Gln Gly Leu Glu Cys Phe Glu Thr Ser Val Lys Glu Met Glu Asn Phe 
145                 150                 155                 160 


Glu Ala Pro Phe His Cys Leu Ala Lys Gln Phe His Gln Leu Tyr Arg 
                165                 170                 175     


Glu Lys Val Glu Val Phe Arg Ala Leu Ala 
            180                 185     


<210>  142
<211>  185
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTRAFLAGELLAR TRANSPORT 27 (IFT27), HOMOLOG ISOFORM 2 
<Accession No.: NP_006851.1>

<400>  142

Met Val Lys Leu Ala Ala Lys Cys Ile Leu Ala Asp Pro Ala Val Gly 
1               5                   10                  15      


Lys Thr Ala Leu Ala Gln Ile Phe Arg Ser Asp Gly Ala His Phe Gln 
            20                  25                  30          


Lys Ser Tyr Thr Leu Thr Thr Gly Met Asp Leu Val Val Lys Thr Val 
        35                  40                  45              


Pro Val Pro Asp Thr Gly Asp Ser Val Glu Leu Phe Ile Phe Asp Ser 
    50                  55                  60                  


Ala Gly Lys Glu Leu Phe Ser Glu Met Leu Asp Lys Leu Trp Glu Ser 
65                  70                  75                  80  


Pro Asn Val Leu Cys Leu Val Tyr Asp Val Thr Asn Glu Glu Ser Phe 
                85                  90                  95      


Asn Asn Cys Ser Lys Trp Leu Glu Lys Ala Arg Ser Gln Ala Pro Gly 
            100                 105                 110         


Ile Ser Leu Pro Gly Val Leu Val Gly Asn Lys Thr Asp Leu Ala Gly 
        115                 120                 125             


Arg Arg Ala Val Asp Ser Ala Glu Ala Arg Ala Trp Ala Leu Gly Gln 
    130                 135                 140                 


Gly Leu Glu Cys Phe Glu Thr Ser Val Lys Glu Met Glu Asn Phe Glu 
145                 150                 155                 160 


Ala Pro Phe His Cys Leu Ala Lys Gln Phe His Gln Leu Tyr Arg Glu 
                165                 170                 175     


Lys Val Glu Val Phe Arg Ala Leu Ala 
            180                 185 


<210>  143
<211>  201
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GUANYLATE CYCLASE ACTIVATOR 1A (GUCA1A) <Accession No.:
 EAX04084.1>

<400>  143

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  144
<211>  276
<212>  PRT
<213>  Homo sapiens

<220>
<223>  OPA1 MITOCHONDRIAL DYNAMIN LIKE GTPASE (OPA1); <Accession No.: 
AAH58013.1>

<400>  144

Met Thr Glu Pro Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys Leu 
1               5                   10                  15      


Lys Glu Ala Val Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn Asp 
            20                  25                  30          


Phe Ala Glu Asp Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu Asp 
        35                  40                  45              


Arg Ser Ile Ser Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe Met 
    50                  55                  60                  


Glu Glu Ala Leu Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile Glu 
65                  70                  75                  80  


Asn Met Val Gly Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys Asn 
                85                  90                  95      


Arg Thr Gln Glu Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu Glu 
            100                 105                 110         


Lys Met Leu Lys Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser Asp 
        115                 120                 125             


Glu Ile Thr Thr Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu Val 
    130                 135                 140                 


Asp Pro Ser Leu Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg His 
145                 150                 155                 160 


Phe Leu Lys Thr Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly Phe 
                165                 170                 175     


Tyr Tyr Tyr Gln Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn Asp 
            180                 185                 190         


Val Val Leu Phe Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala Asn 
        195                 200                 205             


Thr Leu Arg Gln Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu Lys 
    210                 215                 220                 


Asn Val Lys Glu Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys Lys 
225                 230                 235                 240 


Ile Lys Leu Leu Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu Lys 
                245                 250                 255     


Lys Val Arg Glu Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala Leu 
            260                 265                 270         


His Gln Glu Lys 
        275     


<210>  145
<211>  364
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RP1 AXONEMAL MICROTUBULE ASSOCIATED (RP1) <Accession No.: 
AAA20120.1>

<400>  145

Met Gln Lys Trp Phe Ser Ala Phe Asp Asp Ala Ile Ile Gln Arg Gln 
1               5                   10                  15      


Trp Arg Ala Asn Pro Ser Arg Gly Gly Gly Gly Val Ser Phe Thr Lys 
            20                  25                  30          


Glu Val Asp Thr Asn Val Ala Thr Gly Ala Pro Pro Arg Arg Gln Arg 
        35                  40                  45              


Val Pro Gly Arg Ala Cys Pro Trp Arg Glu Pro Ile Arg Gly Arg Arg 
    50                  55                  60                  


Gly Ala Arg Pro Gly Gly Gly Asp Ala Gly Gly Thr Pro Gly Glu Thr 
65                  70                  75                  80  


Val Arg His Cys Ser Ala Pro Glu Asp Pro Ile Phe Arg Phe Ser Ser 
                85                  90                  95      


Leu His Ser Tyr Pro Phe Pro Gly Thr Ile Lys Ser Arg Asp Met Ser 
            100                 105                 110         


Trp Lys Arg His His Leu Ile Pro Glu Thr Phe Gly Val Lys Arg Arg 
        115                 120                 125             


Arg Lys Arg Gly Pro Val Glu Ser Asp Pro Leu Arg Gly Glu Pro Gly 
    130                 135                 140                 


Ser Ala Arg Ala Ala Val Ser Glu Leu Met Gln Leu Phe Pro Arg Gly 
145                 150                 155                 160 


Leu Phe Glu Asp Ala Leu Pro Pro Ile Val Leu Arg Ser Gln Val Tyr 
                165                 170                 175     


Ser Leu Val Pro Asp Arg Thr Val Ala Asp Arg Gln Leu Lys Glu Leu 
            180                 185                 190         


Gln Glu Gln Gly Glu Ile Arg Ile Val Gln Leu Gly Phe Asp Leu Asp 
        195                 200                 205             


Ala His Gly Ile Ile Phe Thr Glu Asp Tyr Arg Thr Arg Val Leu Lys 
    210                 215                 220                 


Ala Cys Asp Gly Arg Pro Tyr Ala Gly Ala Val Gln Lys Phe Leu Ala 
225                 230                 235                 240 


Ser Val Leu Pro Ala Cys Gly Asp Leu Ser Phe Gln Gln Asp Gln Met 
                245                 250                 255     


Thr Gln Thr Phe Gly Phe Arg Asp Ser Glu Ile Thr His Leu Val Asn 
            260                 265                 270         


Ala Gly Val Leu Thr Val Arg Asp Ala Gly Ser Trp Trp Leu Ala Val 
        275                 280                 285             


Pro Gly Ala Gly Arg Phe Ile Lys Tyr Phe Val Lys Gly Arg Gln Ala 
    290                 295                 300                 


Val Leu Ser Met Val Arg Lys Ala Lys Tyr Arg Glu Leu Leu Leu Ser 
305                 310                 315                 320 


Glu Leu Leu Gly Arg Arg Ala Pro Val Val Val Arg Leu Gly Leu Thr 
                325                 330                 335     


Tyr His Val His Asp Leu Ile Gly Ala Gln Leu Val Asp Cys Ile Ser 
            340                 345                 350         


Thr Thr Ser Gly Thr Leu Leu Arg Leu Pro Glu Thr 
        355                 360                 


<210>  146
<211>  350
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RP2 ACTIVATOR OF ARL3 GTPASE (RP2) <Accession No.: ANZ79619.1>

<400>  146

Met Gly Cys Phe Phe Ser Lys Arg Arg Lys Ala Asp Lys Glu Ser Arg 
1               5                   10                  15      


Pro Glu Asn Glu Glu Glu Arg Pro Lys Gln Tyr Ser Trp Asp Gln Arg 
            20                  25                  30          


Glu Lys Val Asp Pro Lys Asp Tyr Met Phe Ser Gly Leu Lys Asp Glu 
        35                  40                  45              


Thr Val Gly Arg Leu Pro Gly Thr Val Ala Gly Gln Gln Phe Leu Ile 
    50                  55                  60                  


Gln Asp Cys Glu Asn Cys Asn Ile Tyr Ile Phe Asp His Ser Ala Thr 
65                  70                  75                  80  


Val Thr Ile Asp Asp Cys Thr Asn Cys Ile Ile Phe Leu Gly Pro Val 
                85                  90                  95      


Lys Gly Ser Val Phe Phe Arg Asn Cys Arg Asp Cys Lys Cys Thr Leu 
            100                 105                 110         


Ala Cys Gln Gln Phe Arg Val Arg Asp Cys Arg Lys Leu Glu Val Phe 
        115                 120                 125             


Leu Cys Cys Ala Thr Gln Pro Ile Ile Glu Ser Ser Ser Asn Ile Lys 
    130                 135                 140                 


Phe Gly Cys Phe Gln Trp Tyr Tyr Pro Glu Leu Ala Phe Gln Phe Lys 
145                 150                 155                 160 


Asp Ala Gly Leu Ser Ile Phe Asn Asn Thr Trp Ser Asn Ile His Asp 
                165                 170                 175     


Phe Thr Pro Val Ser Gly Glu Leu Asn Trp Ser Leu Leu Pro Glu Asp 
            180                 185                 190         


Ala Val Val Gln Asp Tyr Val Pro Ile Pro Thr Thr Glu Glu Leu Lys 
        195                 200                 205             


Ala Val Arg Val Ser Thr Glu Ala Asn Arg Ser Ile Val Pro Ile Ser 
    210                 215                 220                 


Arg Gly Gln Arg Gln Lys Ser Ser Asp Glu Ser Cys Leu Val Val Leu 
225                 230                 235                 240 


Phe Ala Gly Asp Tyr Thr Ile Ala Asn Ala Arg Lys Leu Ile Asp Glu 
                245                 250                 255     


Met Val Gly Lys Gly Phe Phe Leu Val Gln Thr Lys Glu Val Ser Met 
            260                 265                 270         


Lys Ala Glu Asp Ala Gln Arg Val Phe Arg Glu Lys Ala Pro Asp Phe 
        275                 280                 285             


Leu Pro Leu Leu Asn Lys Gly Pro Val Ile Ala Leu Glu Phe Asn Gly 
    290                 295                 300                 


Asp Gly Ala Val Glu Val Cys Gln Leu Ile Val Asn Glu Ile Phe Asn 
305                 310                 315                 320 


Gly Thr Lys Met Phe Val Ser Glu Ser Lys Glu Thr Ala Ser Gly Asp 
                325                 330                 335     


Val Asp Ser Phe Tyr Asn Phe Ala Asp Ile Gln Met Gly Ile 
            340                 345                 350 


<210>  147
<211>  346
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PERIPHERIN 2 (PRPH2) <Accession No.: NP_000313.2>

<400>  147

Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 
1               5                   10                  15      


Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 
            20                  25                  30          


Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 
        35                  40                  45              


Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu 
    50                  55                  60                  


Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys 
65                  70                  75                  80  


Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro 
                85                  90                  95      


Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu 
            100                 105                 110         


Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn 
        115                 120                 125             


Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 
    130                 135                 140                 


Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 
145                 150                 155                 160 


Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 
                165                 170                 175     


Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val 
            180                 185                 190         


Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly 
        195                 200                 205             


Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln 
    210                 215                 220                 


Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr 
225                 230                 235                 240 


Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 
            260                 265                 270         


Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 
        275                 280                 285             


Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Gln 
    290                 295                 300                 


Gly Trp Leu Leu Glu Arg Ser Val Pro Glu Thr Trp Lys Ala Phe Leu 
305                 310                 315                 320 


Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly 
                325                 330                 335     


Ala Asp Ala Gly Gln Ala Pro Glu Ala Gly 
            340                 345     


<210>  148
<211>  499
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 31(PRPF31) <Accession No.: 
AAI17390.1>

<400>  148

Met Ser Leu Ala Asp Glu Leu Leu Ala Asp Leu Glu Glu Ala Ala Glu 
1               5                   10                  15      


Glu Glu Glu Gly Gly Ser Tyr Gly Glu Glu Glu Glu Glu Pro Ala Ile 
            20                  25                  30          


Glu Asp Val Gln Glu Glu Thr Gln Leu Asp Leu Ser Gly Asp Ser Val 
        35                  40                  45              


Lys Thr Ile Ala Lys Leu Trp Asp Ser Lys Met Phe Ala Glu Ile Met 
    50                  55                  60                  


Met Lys Ile Glu Glu Tyr Ile Ser Lys Gln Ala Lys Ala Ser Glu Val 
65                  70                  75                  80  


Met Gly Pro Val Glu Ala Ala Pro Glu Tyr Arg Val Ile Val Asp Ala 
                85                  90                  95      


Asn Asn Leu Thr Val Glu Ile Glu Asn Glu Leu Asn Ile Ile His Lys 
            100                 105                 110         


Phe Ile Arg Asp Lys Tyr Ser Lys Arg Phe Pro Glu Leu Glu Ser Leu 
        115                 120                 125             


Val Pro Asn Ala Leu Asp Tyr Ile Arg Thr Val Lys Glu Leu Gly Asn 
    130                 135                 140                 


Ser Leu Asp Lys Cys Lys Asn Asn Glu Asn Leu Gln Gln Ile Leu Thr 
145                 150                 155                 160 


Asn Ala Thr Ile Met Val Val Ser Val Thr Ala Ser Thr Thr Gln Gly 
                165                 170                 175     


Gln Gln Leu Ser Glu Glu Glu Leu Glu Arg Leu Glu Glu Ala Cys Asp 
            180                 185                 190         


Met Ala Leu Glu Leu Asn Ala Ser Lys His Arg Ile Tyr Glu Tyr Val 
        195                 200                 205             


Glu Ser Arg Met Ser Phe Ile Ala Pro Asn Leu Ser Ile Ile Ile Gly 
    210                 215                 220                 


Ala Ser Thr Ala Ala Lys Ile Met Gly Val Ala Gly Gly Leu Thr Asn 
225                 230                 235                 240 


Leu Ser Lys Met Pro Ala Cys Asn Ile Met Leu Leu Gly Ala Gln Arg 
                245                 250                 255     


Lys Thr Leu Ser Gly Phe Ser Ser Thr Ser Val Leu Pro His Thr Gly 
            260                 265                 270         


Tyr Ile Tyr His Ser Asp Ile Val Gln Ser Leu Pro Pro Asp Leu Arg 
        275                 280                 285             


Arg Lys Ala Ala Arg Leu Val Ala Ala Lys Cys Thr Leu Ala Ala Arg 
    290                 295                 300                 


Val Asp Ser Phe His Glu Ser Thr Glu Gly Lys Val Gly Tyr Glu Leu 
305                 310                 315                 320 


Lys Asp Glu Ile Glu Arg Lys Phe Asp Lys Trp Gln Glu Pro Pro Pro 
                325                 330                 335     


Val Lys Gln Val Lys Pro Leu Pro Ala Pro Leu Asp Gly Gln Arg Lys 
            340                 345                 350         


Lys Arg Gly Gly Arg Arg Tyr Arg Lys Met Lys Glu Arg Leu Gly Leu 
        355                 360                 365             


Thr Glu Ile Arg Lys Gln Ala Asn Arg Met Ser Phe Gly Glu Ile Glu 
    370                 375                 380                 


Glu Asp Ala Tyr Gln Glu Asp Leu Gly Phe Ser Leu Gly His Leu Gly 
385                 390                 395                 400 


Lys Ser Gly Ser Gly Arg Val Arg Gln Thr Gln Val Asn Glu Ala Thr 
                405                 410                 415     


Lys Ala Arg Ile Ser Lys Thr Leu Gln Arg Thr Leu Gln Lys Gln Ser 
            420                 425                 430         


Val Val Tyr Gly Gly Lys Ser Thr Ile Arg Asp Arg Ser Ser Gly Thr 
        435                 440                 445             


Ala Ser Ser Val Ala Phe Thr Pro Leu Gln Gly Leu Glu Ile Val Asn 
    450                 455                 460                 


Pro Gln Ala Ala Glu Lys Lys Val Ala Glu Ala Asn Gln Lys Tyr Phe 
465                 470                 475                 480 


Ser Ser Met Ala Glu Phe Leu Lys Val Lys Gly Glu Lys Ser Gly Leu 
                485                 490                 495     


Met Ser Thr 
            


<210>  149
<211>  499
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 31(PRPF31), ISOFORM CRA_A 
<Accession No.: EAW72190.1>

<400>  149

Met Ser Leu Ala Asp Glu Leu Leu Ala Asp Leu Glu Glu Ala Ala Glu 
1               5                   10                  15      


Glu Glu Glu Gly Gly Ser Tyr Gly Glu Glu Glu Glu Glu Pro Ala Ile 
            20                  25                  30          


Glu Asp Val Gln Glu Glu Thr Gln Leu Asp Leu Ser Gly Asp Ser Val 
        35                  40                  45              


Lys Thr Ile Ala Lys Leu Trp Asp Ser Lys Met Phe Ala Glu Ile Met 
    50                  55                  60                  


Met Lys Ile Glu Glu Tyr Ile Ser Lys Gln Ala Lys Ala Ser Glu Val 
65                  70                  75                  80  


Met Gly Pro Val Glu Ala Ala Pro Glu Tyr Arg Val Ile Val Asp Ala 
                85                  90                  95      


Asn Asn Leu Thr Val Glu Ile Glu Asn Glu Leu Asn Ile Ile His Lys 
            100                 105                 110         


Phe Ile Arg Asp Lys Tyr Ser Lys Arg Phe Pro Glu Leu Glu Ser Leu 
        115                 120                 125             


Val Pro Asn Ala Leu Asp Tyr Ile Arg Thr Val Lys Glu Leu Gly Asn 
    130                 135                 140                 


Ser Leu Asp Lys Cys Lys Asn Asn Glu Asn Leu Gln Gln Ile Leu Thr 
145                 150                 155                 160 


Asn Ala Thr Ile Met Val Val Ser Val Thr Ala Ser Thr Thr Gln Gly 
                165                 170                 175     


Gln Gln Leu Ser Glu Glu Glu Leu Glu Arg Leu Glu Glu Ala Cys Asp 
            180                 185                 190         


Met Ala Leu Glu Leu Asn Ala Ser Lys His Arg Ile Tyr Glu Tyr Val 
        195                 200                 205             


Glu Ser Arg Met Ser Phe Ile Ala Pro Asn Leu Ser Ile Ile Ile Gly 
    210                 215                 220                 


Ala Ser Thr Ala Ala Lys Ile Met Gly Val Ala Gly Gly Leu Thr Asn 
225                 230                 235                 240 


Leu Ser Lys Met Pro Ala Cys Asn Ile Met Leu Leu Gly Ala Gln Arg 
                245                 250                 255     


Lys Thr Leu Ser Gly Phe Ser Ser Thr Ser Val Leu Pro His Thr Gly 
            260                 265                 270         


Tyr Ile Tyr His Ser Asp Ile Val Gln Ser Leu Pro Pro Asp Leu Arg 
        275                 280                 285             


Arg Lys Ala Ala Arg Leu Val Ala Ala Lys Cys Thr Leu Ala Ala Arg 
    290                 295                 300                 


Val Asp Ser Phe His Glu Ser Thr Glu Gly Lys Val Gly Tyr Glu Leu 
305                 310                 315                 320 


Lys Asp Glu Ile Glu Arg Lys Phe Asp Lys Trp Gln Glu Pro Pro Pro 
                325                 330                 335     


Val Lys Gln Val Lys Pro Leu Pro Ala Pro Leu Asp Gly Gln Arg Lys 
            340                 345                 350         


Lys Arg Gly Gly Arg Arg Tyr Arg Lys Met Lys Glu Arg Leu Gly Leu 
        355                 360                 365             


Thr Glu Ile Arg Lys Gln Ala Asn Arg Met Ser Phe Gly Glu Ile Glu 
    370                 375                 380                 


Glu Asp Ala Tyr Gln Glu Asp Leu Gly Phe Ser Leu Gly His Leu Gly 
385                 390                 395                 400 


Lys Ser Gly Ser Gly Arg Val Arg Gln Thr Gln Val Asn Glu Ala Thr 
                405                 410                 415     


Lys Ala Arg Ile Ser Lys Thr Leu Gln Arg Thr Leu Gln Lys Gln Ser 
            420                 425                 430         


Val Val Tyr Gly Gly Lys Ser Thr Ile Arg Asp Arg Ser Ser Gly Thr 
        435                 440                 445             


Ala Ser Ser Val Ala Phe Thr Pro Leu Gln Gly Leu Glu Ile Val Asn 
    450                 455                 460                 


Pro Gln Ala Ala Glu Lys Lys Val Ala Glu Ala Asn Gln Lys Tyr Phe 
465                 470                 475                 480 


Ser Ser Met Ala Glu Phe Leu Lys Val Lys Gly Glu Lys Ser Gly Leu 
                485                 490                 495     


Met Ser Thr 
            


<210>  150
<211>  300
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 31(PRPF31), ISOFORM CRA_A 
<Accession No.: EAW72191.1>

<400>  150

Met Phe Ala Glu Ile Met Met Lys Ile Glu Glu Tyr Ile Ser Lys Gln 
1               5                   10                  15      


Ala Lys Ala Ser Glu Val Met Gly Pro Val Glu Ala Ala Pro Glu Tyr 
            20                  25                  30          


Arg Val Ile Val Asp Ala Asn Asn Leu Thr Val Glu Ile Glu Asn Glu 
        35                  40                  45              


Leu Asn Ile Ile His Lys Phe Ile Arg Asp Lys Tyr Ser Lys Arg Phe 
    50                  55                  60                  


Pro Glu Leu Glu Ser Leu Val Pro Asn Ala Leu Asp Tyr Ile Arg Thr 
65                  70                  75                  80  


Val Lys Glu Leu Gly Asn Ser Leu Asp Lys Cys Lys Asn Asn Glu Asn 
                85                  90                  95      


Leu Gln Gln Ile Leu Thr Asn Ala Thr Ile Met Val Val Ser Val Thr 
            100                 105                 110         


Ala Ser Thr Thr Gln Gly Gln Gln Leu Ser Glu Glu Glu Leu Glu Arg 
        115                 120                 125             


Leu Glu Glu Ala Cys Asp Met Ala Leu Glu Leu Asn Ala Ser Lys His 
    130                 135                 140                 


Arg Ile Tyr Glu Tyr Val Glu Ser Arg Met Ser Phe Ile Ala Pro Asn 
145                 150                 155                 160 


Leu Ser Ile Ile Ile Gly Ala Ser Thr Ala Ala Lys Ile Met Gly Val 
                165                 170                 175     


Ala Gly Gly Leu Thr Asn Leu Ser Lys Met Pro Ala Cys Asn Ile Met 
            180                 185                 190         


Leu Leu Gly Ala Gln Arg Lys Thr Leu Ser Gly Phe Ser Ser Thr Ser 
        195                 200                 205             


Val Leu Pro His Thr Gly Tyr Ile Tyr His Ser Asp Ile Val Gln Ser 
    210                 215                 220                 


Leu Pro Pro Asp Leu Arg Arg Lys Ala Ala Arg Leu Val Ala Ala Lys 
225                 230                 235                 240 


Cys Thr Leu Ala Ala Arg Val Asp Ser Phe His Glu Ser Thr Glu Gly 
                245                 250                 255     


Lys Val Gly Tyr Glu Leu Lys Asp Glu Ile Glu Arg Lys Phe Asp Lys 
            260                 265                 270         


Trp Gln Glu Pro Pro Pro Val Lys Gln Val Lys Pro Leu Pro Ala Pro 
        275                 280                 285             


Leu Asp Gly Gln Arg Lys Lys Arg Gly Gly Arg Arg 
    290                 295                 300 


<210>  151
<211>  2335
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8) <Accession No.: 
AAH64370.1>

<400>  151

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln His Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210>  152
<211>  2145
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_A 
<Accession No.: EAW90588.1>

<400>  152

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Val Ser  Lys Trp Thr Gln Leu  Gly His Ser 
    2120                 2125                 2130             


Val Cys  Pro Thr His Phe Val  Pro Lys Thr Gln Thr  
    2135                 2140                 2145 


<210>  153
<211>  2335
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_B 
<Accession No.: EAW90589.1>

<400>  153

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Cys Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210>  154
<211>  103
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_C 
<Accession No.: EAW90590.1>

<400>  154

Met Met Ser Thr Leu Tyr Arg Gln Asn Thr Asp Lys Gly Asn Asn Pro 
1               5                   10                  15      


Lys Gly Tyr Leu Pro Ser His Tyr Glu Arg Val Gln Met Leu Leu Ser 
            20                  25                  30          


Asp Arg Phe Leu Gly Phe Phe Met Val Pro Ala Gln Ser Ser Trp Asn 
        35                  40                  45              


Tyr Asn Phe Met Gly Val Arg His Asp Pro Asn Met Lys Tyr Glu Leu 
    50                  55                  60                  


Gln Leu Ala Asn Pro Lys Glu Phe Tyr His Glu Val His Arg Pro Ser 
65                  70                  75                  80  


His Phe Leu Asn Phe Ala Leu Leu Gln Glu Gly Glu Val Tyr Ser Ala 
                85                  90                  95      


Asp Arg Glu Asp Leu Tyr Ala 
            100             


<210>  155
<211>  1525
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_D 
<Accession No.: EAW90591.1>

<400>  155

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Cys Glu Gln  Arg Ser Gly 
    1490                 1495                 1500             


Lys Ser  Asp Pro Glu Ala Arg  Gln Asp Tyr Tyr Tyr  Arg Thr Thr 
    1505                 1510                 1515             


Pro His  Leu Ala His Ser Asp  
    1520                 1525 


<210>  156
<211>  132
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_E 
<Accession No.: EAW90592.1>

<400>  156

Met Glu Ile Ser Ala Pro Ser Gln Gln Arg Gln Gln Ile Ala Glu Ile 
1               5                   10                  15      


Glu Lys Gln Thr Lys Glu Gln Ser Gln Leu Thr Ala Thr Gln Thr Arg 
            20                  25                  30          


Thr Val Asn Lys His Gly Asp Glu Ile Ile Thr Ser Thr Thr Ser Asn 
        35                  40                  45              


Tyr Glu Thr Gln Thr Phe Ser Ser Lys Thr Glu Trp Arg Val Arg Ala 
    50                  55                  60                  


Ile Ser Ala Ala Asn Leu His Leu Arg Thr Asn His Ile Tyr Val Ser 
65                  70                  75                  80  


Ser Asp Asp Ile Lys Glu Thr Gly Tyr Thr Tyr Ile Leu Pro Lys Asn 
                85                  90                  95      


Val Leu Lys Lys Phe Ile Cys Ile Ser Asp Leu Arg Ala Gln Val Ser 
            100                 105                 110         


Lys Trp Thr Gln Leu Gly His Ser Val Cys Pro Thr His Phe Val Pro 
        115                 120                 125             


Lys Thr Gln Thr 
    130         


<210>  157
<211>  2335
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_F 
<Accession No.: EAW90593.1>

<400>  157

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210>  158
<211>  268
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PRE-MRNA PROCESSING FACTOR 8 (PRPF8), ISOFORM CRA_G 
<Accession No.: EAW90594.1>

<400>  158

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Met Ser Pro Pro Met 
225                 230                 235                 240 


Pro Arg Ser Trp Leu Thr Thr His Leu Gly Met Ala Arg Arg Pro Leu 
                245                 250                 255     


Ser Ser His Ala Ala Ser Arg Gln Ala Pro Val His 
            260                 265             


<210>  159
<211>  3165
<212>  PRT
<213>  Homo sapiens

<220>
<223>  EYES SHUT HOMOLOG (EYS) <Accession No.: CAR64275.1>

<400>  159

Met Thr Asp Lys Ser Ile Val Ile Leu Ser Leu Met Val Phe His Ser 
1               5                   10                  15      


Ser Phe Ile Asn Gly Lys Thr Cys Arg Arg Gln Leu Val Glu Glu Trp 
            20                  25                  30          


His Pro Gln Pro Ser Ser Tyr Val Val Asn Trp Thr Leu Thr Glu Asn 
        35                  40                  45              


Ile Cys Leu Asp Phe Tyr Arg Asp Cys Trp Phe Leu Gly Val Asn Thr 
    50                  55                  60                  


Lys Ile Asp Thr Ser Gly Asn Gln Ala Val Pro Gln Ile Cys Pro Leu 
65                  70                  75                  80  


Gln Ile Gln Leu Gly Asp Ile Leu Val Ile Ser Ser Glu Pro Ser Leu 
                85                  90                  95      


Gln Phe Pro Glu Ile Asn Leu Met Asn Val Ser Glu Thr Ser Phe Val 
            100                 105                 110         


Gly Cys Val Gln Asn Thr Thr Thr Glu Asp Gln Leu Leu Phe Gly Cys 
        115                 120                 125             


Arg Leu Lys Gly Met His Thr Val Asn Ser Lys Trp Leu Ser Val Gly 
    130                 135                 140                 


Thr His Tyr Phe Ile Thr Val Met Ala Ser Gly Pro Ser Pro Cys Pro 
145                 150                 155                 160 


Leu Gly Leu Arg Leu Asn Val Thr Val Lys Gln Gln Phe Cys Gln Glu 
                165                 170                 175     


Ser Leu Ser Ser Glu Phe Cys Ser Gly His Gly Lys Cys Leu Ser Glu 
            180                 185                 190         


Ala Trp Ser Lys Thr Tyr Ser Cys His Cys Gln Pro Pro Phe Ser Gly 
        195                 200                 205             


Lys Tyr Cys Gln Glu Leu Asp Ala Cys Ser Phe Lys Pro Cys Lys Asn 
    210                 215                 220                 


Asn Gly Ser Cys Ile Asn Lys Arg Glu Asn Trp Asp Glu Gln Ala Tyr 
225                 230                 235                 240 


Glu Cys Val Cys His Pro Pro Phe Thr Gly Lys Asn Cys Ser Glu Ile 
                245                 250                 255     


Ile Gly Gln Cys Gln Pro His Val Cys Phe His Gly Asn Cys Ser Asn 
            260                 265                 270         


Ile Thr Ser Asn Ser Phe Ile Cys Glu Cys Asp Glu Gln Phe Ser Gly 
        275                 280                 285             


Pro Phe Cys Glu Val Ser Ala Lys Pro Cys Val Ser Leu Leu Phe Trp 
    290                 295                 300                 


Lys Arg Gly Ile Cys Pro Asn Ser Ser Ser Ala Tyr Thr Tyr Glu Cys 
305                 310                 315                 320 


Pro Lys Gly Ser Ser Ser Gln Asn Gly Glu Thr Asp Val Ser Glu Phe 
                325                 330                 335     


Ser Leu Val Pro Cys Gln Asn Gly Thr Asp Cys Ile Lys Ile Ser Asn 
            340                 345                 350         


Asp Val Met Cys Ile Cys Ser Pro Ile Phe Thr Asp Leu Leu Cys Lys 
        355                 360                 365             


Ser Ile Gln Thr Ser Cys Glu Ser Phe Pro Leu Arg Asn Asn Ala Thr 
    370                 375                 380                 


Cys Lys Lys Cys Glu Lys Asp Tyr Pro Cys Ser Cys Ile Ser Gly Phe 
385                 390                 395                 400 


Thr Glu Lys Asn Cys Glu Lys Ala Ile Asp His Cys Lys Leu Leu Ser 
                405                 410                 415     


Ile Asn Cys Leu Asn Glu Glu Trp Cys Phe Asn Ile Ile Gly Arg Phe 
            420                 425                 430         


Lys Tyr Val Cys Ile Pro Gly Cys Thr Lys Asn Pro Cys Trp Phe Leu 
        435                 440                 445             


Lys Asn Val Tyr Leu Ile His Gln His Leu Cys Tyr Cys Gly Val Thr 
    450                 455                 460                 


Phe His Gly Ile Cys Gln Asp Lys Gly Pro Ala Gln Phe Glu Tyr Val 
465                 470                 475                 480 


Trp Gln Leu Gly Phe Ala Gly Ser Glu Gly Glu Lys Cys Gln Gly Val 
                485                 490                 495     


Ile Asp Ala Tyr Phe Phe Leu Ala Ala Asn Cys Thr Glu Asp Ala Thr 
            500                 505                 510         


Tyr Val Asn Asp Pro Glu Asp Asn Asn Ser Ser Cys Trp Phe Pro His 
        515                 520                 525             


Glu Gly Thr Lys Glu Ile Cys Ala Asn Gly Cys Ser Cys Leu Ser Glu 
    530                 535                 540                 


Glu Asp Ser Gln Glu Tyr Arg Tyr Leu Cys Phe Leu Arg Trp Ala Gly 
545                 550                 555                 560 


Asn Met Tyr Leu Glu Asn Thr Thr Asp Asp Gln Glu Asn Glu Cys Gln 
                565                 570                 575     


His Glu Ala Val Cys Lys Asp Glu Ile Asn Arg Pro Arg Cys Ser Cys 
            580                 585                 590         


Ser Leu Ser Tyr Ile Gly Arg Leu Cys Val Val Asn Val Asp Tyr Cys 
        595                 600                 605             


Leu Gly Asn His Ser Ile Ser Val His Gly Leu Cys Leu Ala Leu Ser 
    610                 615                 620                 


His Asn Cys Asn Cys Ser Gly Leu Gln Arg Tyr Glu Arg Asn Ile Cys 
625                 630                 635                 640 


Glu Ile Asp Thr Glu Asp Cys Lys Ser Ala Ser Arg Lys Asn Gly Thr 
                645                 650                 655     


Thr Ser Thr His Leu Arg Gly Tyr Phe Phe Arg Lys Cys Val Pro Gly 
            660                 665                 670         


Phe Lys Gly Thr Gln Cys Glu Ile Asp Ile Asp Glu Cys Ala Ser His 
        675                 680                 685             


Pro Cys Lys Asn Gly Ala Thr Cys Ile Asp Gln Pro Gly Asn Tyr Phe 
    690                 695                 700                 


Cys Gln Cys Val Pro Pro Phe Lys Val Val Asp Gly Phe Ser Cys Leu 
705                 710                 715                 720 


Cys Asn Pro Gly Tyr Val Gly Ile Arg Cys Glu Gln Asp Ile Asp Asp 
                725                 730                 735     


Cys Ile Leu Asn Ala Cys Glu His Asn Ser Thr Cys Lys Asp Leu His 
            740                 745                 750         


Leu Ser Tyr Gln Cys Val Cys Leu Ser Asp Trp Glu Gly Asn Phe Cys 
        755                 760                 765             


Glu Gln Glu Ser Asn Glu Cys Lys Met Asn Pro Cys Lys Asn Asn Ser 
    770                 775                 780                 


Thr Cys Thr Asp Leu Tyr Lys Ser Tyr Arg Cys Glu Cys Thr Ser Gly 
785                 790                 795                 800 


Trp Thr Gly Gln Asn Cys Ser Glu Glu Ile Asn Glu Cys Asp Ser Asp 
                805                 810                 815     


Pro Cys Met Asn Gly Gly Leu Cys His Glu Ser Thr Ile Pro Gly Gln 
            820                 825                 830         


Phe Val Cys Leu Cys Pro Pro Leu Tyr Thr Gly Gln Phe Cys His Gln 
        835                 840                 845             


Arg Tyr Asn Leu Cys Asp Leu Leu His Asn Pro Cys Arg Asn Asn Ser 
    850                 855                 860                 


Thr Cys Leu Ala Leu Val Asp Ala Asn Gln His Cys Ile Cys Arg Glu 
865                 870                 875                 880 


Glu Phe Glu Gly Lys Asn Cys Glu Ile Asp Val Lys Asp Cys Leu Phe 
                885                 890                 895     


Leu Ser Cys Gln Asp Tyr Gly Asp Cys Glu Asp Met Val Asn Asn Phe 
            900                 905                 910         


Arg Cys Ile Cys Arg Pro Gly Phe Ser Gly Ser Leu Cys Glu Ile Glu 
        915                 920                 925             


Ile Asn Glu Cys Ser Ser Glu Pro Cys Lys Asn Asn Gly Thr Cys Val 
    930                 935                 940                 


Asp Leu Thr Asn Arg Phe Phe Cys Asn Cys Glu Pro Glu Tyr His Gly 
945                 950                 955                 960 


Pro Phe Cys Glu Leu Asp Val Asn Lys Cys Lys Ile Ser Pro Cys Leu 
                965                 970                 975     


Asp Glu Glu Asn Cys Val Tyr Arg Thr Asp Gly Tyr Asn Cys Leu Cys 
            980                 985                 990         


Ala Pro Gly Tyr Thr Gly Ile Asn  Cys Glu Ile Asn Leu  Asp Glu Cys 
        995                 1000                 1005             


Leu Ser  Glu Pro Cys Leu His  Asp Gly Val Cys Ile  Asp Gly Ile 
    1010                 1015                 1020             


Asn His  Tyr Thr Cys Asp Cys  Lys Ser Gly Phe Phe  Gly Thr His 
    1025                 1030                 1035             


Cys Glu  Thr Asn Ala Asn Asp  Cys Leu Ser Asn Pro  Cys Leu His 
    1040                 1045                 1050             


Gly Arg  Tyr Thr Glu Leu Ile  Asn Glu Tyr Pro Cys  Ser Cys Asp 
    1055                 1060                 1065             


Ala Asp  Gly Thr Ser Thr Gln  Cys Lys Ile Lys Ile  Asn Asp Cys 
    1070                 1075                 1080             


Thr Ser  Ile Pro Cys Met Asn  Glu Gly Phe Cys Gln  Lys Ser Ala 
    1085                 1090                 1095             


His Gly  Phe Thr Cys Ile Cys  Pro Arg Gly Tyr Thr  Gly Ala Tyr 
    1100                 1105                 1110             


Cys Glu  Lys Ser Ile Asp Asn  Cys Ala Glu Pro Glu  Leu Asn Ser 
    1115                 1120                 1125             


Val Ile  Cys Leu Asn Gly Gly  Ile Cys Val Asp Gly  Pro Gly His 
    1130                 1135                 1140             


Thr Phe  Asp Cys Arg Cys Leu  Pro Gly Phe Ser Gly  Gln Phe Cys 
    1145                 1150                 1155             


Glu Ile  Asn Ile Asn Glu Cys  Ser Ser Ser Pro Cys  Leu His Gly 
    1160                 1165                 1170             


Ala Asp  Cys Glu Asp His Ile  Asn Gly His Val Cys  Lys Cys Gln 
    1175                 1180                 1185             


Pro Gly  Trp Ser Gly His His  Cys Glu Asn Glu Leu  Glu Cys Ile 
    1190                 1195                 1200             


Pro Asn  Ser Cys Val His Glu  Leu Cys Met Glu Asn  Glu Pro Gly 
    1205                 1210                 1215             


Ser Thr  Cys Leu Cys Thr Pro  Gly Phe Met Thr Cys  Ser Ile Gly 
    1220                 1225                 1230             


Leu Leu  Cys Gly Asp Glu Ile  Arg Arg Ile Thr Cys  Leu Thr Pro 
    1235                 1240                 1245             


Ile Phe  Gln Arg Thr Asp Pro  Ile Ser Thr Gln Thr  Tyr Thr Ile 
    1250                 1255                 1260             


Pro Pro  Ser Glu Thr Leu Val  Ser Ser Phe Pro Ser  Ile Lys Ala 
    1265                 1270                 1275             


Thr Arg  Ile Pro Ala Ile Met  Asp Thr Tyr Pro Val  Asp Gln Gly 
    1280                 1285                 1290             


Pro Lys  Gln Thr Gly Ile Val  Lys His Asp Ile Leu  Pro Thr Thr 
    1295                 1300                 1305             


Gly Leu  Ala Thr Leu Arg Ile  Ser Thr Pro Leu Glu  Ser Tyr Leu 
    1310                 1315                 1320             


Leu Gln  Glu Leu Ile Val Thr  Arg Glu Leu Ser Ala  Lys His Ser 
    1325                 1330                 1335             


Leu Leu  Ser Ser Ala Asp Val  Ser Ser Ser Arg Phe  Leu Asn Phe 
    1340                 1345                 1350             


Gly Ile  Arg Asp Pro Ala Gln  Ile Val Gln Asp Lys  Thr Ser Val 
    1355                 1360                 1365             


Ser His  Met Pro Ile Arg Thr  Ser Ala Ala Thr Leu  Gly Phe Phe 
    1370                 1375                 1380             


Phe Pro  Asp Arg Arg Ala Arg  Thr Pro Phe Ile Met  Ser Ser Leu 
    1385                 1390                 1395             


Met Ser  Asp Phe Ile Phe Pro  Thr Gln Ser Leu Leu  Phe Glu Asn 
    1400                 1405                 1410             


Cys Gln  Thr Val Ala Leu Ser  Ala Thr Pro Thr Thr  Ser Val Ile 
    1415                 1420                 1425             


Arg Ser  Ile Pro Gly Ala Asp  Ile Glu Leu Asn Arg  Gln Ser Leu 
    1430                 1435                 1440             


Leu Ser  Arg Gly Phe Leu Leu  Ile Ala Ala Ser Ile  Ser Ala Thr 
    1445                 1450                 1455             


Pro Val  Val Ser Arg Gly Ala  Gln Glu Asp Ile Glu  Glu Tyr Ser 
    1460                 1465                 1470             


Ala Asp  Ser Leu Ile Ser Arg  Arg Glu His Trp Arg  Leu Leu Ser 
    1475                 1480                 1485             


Pro Ser  Met Ser Pro Ile Phe  Pro Ala Lys Val Ile  Ile Ser Lys 
    1490                 1495                 1500             


Gln Val  Thr Ile Leu Asn Ser  Ser Ala Leu His Arg  Phe Ser Thr 
    1505                 1510                 1515             


Lys Ala  Phe Asn Pro Ser Glu  Tyr Gln Ala Ile Thr  Glu Ala Ser 
    1520                 1525                 1530             


Ser Asn  Gln Arg Leu Thr Asn  Ile Lys Ser Gln Ala  Ala Asp Ser 
    1535                 1540                 1545             


Leu Arg  Glu Leu Ser Gln Thr  Cys Ala Thr Cys Ser  Met Thr Glu 
    1550                 1555                 1560             


Ile Lys  Ser Ser Arg Glu Phe  Ser Asp Gln Val Leu  His Ser Lys 
    1565                 1570                 1575             


Gln Ser  His Phe Tyr Glu Thr  Phe Trp Met Asn Ser  Ala Ile Leu 
    1580                 1585                 1590             


Ala Ser  Trp Tyr Ala Leu Met  Gly Ala Gln Thr Ile  Thr Ser Gly 
    1595                 1600                 1605             


His Ser  Phe Ser Ser Ala Thr  Glu Ile Thr Pro Ser  Val Ala Phe 
    1610                 1615                 1620             


Thr Glu  Val Pro Ser Leu Phe  Pro Ser Lys Lys Ser  Ala Lys Arg 
    1625                 1630                 1635             


Thr Ile  Leu Ser Ser Ser Leu  Glu Glu Ser Ile Thr  Leu Ser Ser 
    1640                 1645                 1650             


Asn Leu  Asp Val Asn Leu Cys  Leu Asp Lys Thr Cys  Leu Ser Ile 
    1655                 1660                 1665             


Val Pro  Ser Gln Thr Ile Ser  Ser Asp Leu Met Asn  Ser Asp Leu 
    1670                 1675                 1680             


Thr Ser  Lys Met Thr Thr Asp  Glu Leu Ser Val Ser  Glu Asn Ile 
    1685                 1690                 1695             


Leu Lys  Leu Leu Lys Ile Arg  Gln Tyr Gly Ile Thr  Met Gly Pro 
    1700                 1705                 1710             


Thr Glu  Val Leu Asn Gln Glu  Ser Leu Leu Asp Met  Glu Lys Ser 
    1715                 1720                 1725             


Lys Gly  Ser His Thr Leu Phe  Lys Leu His Pro Ser  Asp Ser Ser 
    1730                 1735                 1740             


Leu Asp  Phe Glu Leu Asn Leu  Gln Ile Tyr Pro Asp  Val Thr Leu 
    1745                 1750                 1755             


Lys Thr  Tyr Ser Glu Ile Thr  His Ala Asn Asp Phe  Lys Asn Asn 
    1760                 1765                 1770             


Leu Pro  Pro Leu Thr Gly Ser  Val Pro Asp Phe Ser  Glu Val Thr 
    1775                 1780                 1785             


Thr Asn  Val Ala Phe Tyr Thr  Val Ser Ala Thr Pro  Ala Leu Ser 
    1790                 1795                 1800             


Ile Gln  Thr Ser Ser Ser Met  Ser Val Ile Arg Pro  Asp Trp Pro 
    1805                 1810                 1815             


Tyr Phe  Thr Asp Tyr Met Thr  Ser Leu Lys Lys Glu  Val Lys Thr 
    1820                 1825                 1830             


Ser Ser  Glu Trp Ser Lys Trp  Glu Leu Gln Pro Ser  Val Gln Tyr 
    1835                 1840                 1845             


Gln Glu  Phe Pro Thr Ala Ser  Arg His Leu Pro Phe  Thr Arg Ser 
    1850                 1855                 1860             


Leu Thr  Leu Ser Ser Leu Glu  Ser Ile Leu Ala Pro  Gln Arg Leu 
    1865                 1870                 1875             


Met Ile  Ser Asp Phe Ser Cys  Val Arg Tyr Tyr Gly  Asp Ser Tyr 
    1880                 1885                 1890             


Leu Glu  Phe Gln Asn Val Ala  Leu Asn Pro Gln Asn  Asn Ile Ser 
    1895                 1900                 1905             


Leu Glu  Phe Gln Thr Phe Ser  Ser Tyr Gly Leu Leu  Leu His Val 
    1910                 1915                 1920             


Lys Gln  Asp Ser Asn Leu Val  Asp Gly Phe Phe Ile  Gln Leu Phe 
    1925                 1930                 1935             


Ile Glu  Asn Gly Thr Leu Lys  Tyr His Phe Tyr Cys  Pro Gly Glu 
    1940                 1945                 1950             


Ala Lys  Phe Lys Ser Ile Asn  Thr Thr Val Arg Val  Asp Asn Gly 
    1955                 1960                 1965             


Gln Lys  Tyr Thr Leu Leu Ile  Arg Gln Glu Leu Asp  Pro Cys Asn 
    1970                 1975                 1980             


Ala Glu  Leu Thr Ile Leu Gly  Arg Asn Thr Gln Ile  Cys Glu Ser 
    1985                 1990                 1995             


Ile Asn  His Val Leu Gly Lys  Pro Leu Pro Lys Ser  Gly Ser Val 
    2000                 2005                 2010             


Phe Ile  Gly Gly Phe Pro Asp  Leu His Gly Lys Ile  Gln Met Pro 
    2015                 2020                 2025             


Val Pro  Val Lys Asn Phe Thr  Gly Cys Ile Glu Val  Ile Glu Ile 
    2030                 2035                 2040             


Asn Asn  Trp Arg Ser Phe Ile  Pro Ser Lys Ala Val  Lys Asn Tyr 
    2045                 2050                 2055             


His Ile  Asn Asn Cys Arg Ser  Gln Gly Phe Met Leu  Ser Pro Thr 
    2060                 2065                 2070             


Ala Ser  Phe Val Asp Ala Ser  Asp Val Thr Gln Gly  Val Asp Thr 
    2075                 2080                 2085             


Met Trp  Thr Ser Val Ser Pro  Ser Val Ala Ala Pro  Ser Val Cys 
    2090                 2095                 2100             


Gln Gln  Asp Val Cys His Asn  Gly Gly Thr Cys His  Ala Ile Phe 
    2105                 2110                 2115             


Leu Ser  Ser Gly Ile Val Ser  Phe Gln Cys Asp Cys  Pro Leu His 
    2120                 2125                 2130             


Phe Thr  Gly Arg Phe Cys Glu  Lys Asp Ala Gly Leu  Phe Phe Pro 
    2135                 2140                 2145             


Ser Phe  Asn Gly Asn Ser Tyr  Leu Glu Leu Pro Phe  Leu Lys Phe 
    2150                 2155                 2160             


Val Leu  Glu Lys Glu His Asn  Arg Thr Val Thr Ile  Tyr Leu Thr 
    2165                 2170                 2175             


Ile Lys  Thr Asn Ser Leu Asn  Gly Thr Ile Leu Tyr  Ser Asn Gly 
    2180                 2185                 2190             


Asn Asn  Cys Gly Lys Gln Phe  Leu His Leu Phe Leu  Val Glu Gly 
    2195                 2200                 2205             


Arg Pro  Ser Val Lys Tyr Gly  Cys Gly Asn Ser Gln  Asn Ile Leu 
    2210                 2215                 2220             


Thr Val  Ser Ala Asn Tyr Ser  Ile Asn Thr Asn Ala  Phe Thr Pro 
    2225                 2230                 2235             


Ile Thr  Ile Arg Tyr Thr Thr  Pro Val Gly Ser Pro  Gly Val Val 
    2240                 2245                 2250             


Cys Met  Ile Glu Met Thr Ala  Asp Gly Lys Pro Pro  Val Gln Lys 
    2255                 2260                 2265             


Lys Asp  Thr Glu Ile Ser His  Ala Ser Gln Ala Tyr  Phe Glu Ser 
    2270                 2275                 2280             


Met Phe  Leu Gly His Ile Pro  Ala Asn Val Gln Ile  His Lys Lys 
    2285                 2290                 2295             


Ala Gly  Pro Val Tyr Gly Phe  Arg Gly Cys Ile Leu  Asp Leu Gln 
    2300                 2305                 2310             


Val Asn  Asn Lys Glu Phe Phe  Ile Ile Asp Glu Ala  Arg His Gly 
    2315                 2320                 2325             


Lys Asn  Ile Glu Asn Cys His  Val Pro Trp Cys Ala  His His Leu 
    2330                 2335                 2340             


Cys Arg  Asn Asn Gly Thr Cys  Ile Ser Asp Asn Glu  Asn Leu Phe 
    2345                 2350                 2355             


Cys Glu  Cys Pro Arg Leu Tyr  Ser Gly Lys Leu Cys  Gln Phe Ala 
    2360                 2365                 2370             


Ser Cys  Glu Asn Asn Pro Cys  Gly Asn Gly Ala Thr  Cys Val Pro 
    2375                 2380                 2385             


Lys Ser  Gly Thr Asp Ile Val  Cys Leu Cys Pro Tyr  Gly Arg Ser 
    2390                 2395                 2400             


Gly Pro  Leu Cys Thr Asp Ala  Ile Asn Ile Thr Gln  Pro Arg Phe 
    2405                 2410                 2415             


Ser Gly  Thr Asp Ala Phe Gly  Tyr Thr Ser Phe Leu  Ala Tyr Ser 
    2420                 2425                 2430             


Arg Ile  Ser Asp Ile Ser Phe  Arg Tyr Glu Phe His  Leu Lys Phe 
    2435                 2440                 2445             


Gln Leu  Ala Asn Asn His Ser  Ala Leu Gln Asn Asn  Leu Ile Phe 
    2450                 2455                 2460             


Phe Thr  Glu Gln Lys Gly His  Gly Leu Asn Gly Asp  Asp Phe Leu 
    2465                 2470                 2475             


Ala Val  Gly Leu Leu Asn Gly  Ser Val Val Tyr Ser  Tyr Asn Leu 
    2480                 2485                 2490             


Gly Ser  Gly Ile Ala Ser Ile  Arg Ser Glu Pro Leu  Asn Leu Ser 
    2495                 2500                 2505             


Leu Gly  Val His Thr Val His  Leu Gly Lys Phe Phe  Gln Glu Gly 
    2510                 2515                 2520             


Trp Leu  Lys Val Asp Asp His  Lys Asn Lys Ser Ile  Ile Ala Pro 
    2525                 2530                 2535             


Gly Arg  Leu Val Gly Leu Asn  Val Phe Ser Gln Phe  Tyr Val Gly 
    2540                 2545                 2550             


Gly Tyr  Ser Glu Tyr Thr Pro  Asp Leu Leu Pro Asn  Gly Ala Asp 
    2555                 2560                 2565             


Phe Lys  Asn Gly Phe Gln Gly  Cys Ile Phe Thr Leu  Gln Val Arg 
    2570                 2575                 2580             


Thr Glu  Lys Asp Gly His Phe  Arg Gly Leu Gly Asn  Pro Glu Gly 
    2585                 2590                 2595             


His Pro  Asn Ala Gly Arg Ser  Val Gly Gln Cys His  Ala Ser Pro 
    2600                 2605                 2610             


Cys Ser  Leu Met Lys Cys Gly  Asn Gly Gly Thr Cys  Ile Glu Ser 
    2615                 2620                 2625             


Gly Thr  Ser Val Tyr Cys Asn  Cys Thr Thr Gly Trp  Lys Gly Ser 
    2630                 2635                 2640             


Phe Cys  Thr Glu Thr Val Ser  Thr Cys Asp Pro Glu  His Asp Pro 
    2645                 2650                 2655             


Pro His  His Cys Ser Arg Gly  Ala Thr Cys Ile Ser  Leu Pro His 
    2660                 2665                 2670             


Gly Tyr  Thr Cys Phe Cys Pro  Leu Gly Thr Thr Gly  Ile Tyr Cys 
    2675                 2680                 2685             


Glu Gln  Ala Leu Ile Leu Ile  Val Ile Leu Glu Lys  Pro Lys Pro 
    2690                 2695                 2700             


Ala Glu  Arg Lys Val Lys Lys  Glu Ala Leu Ser Ile  Ser Asp Pro 
    2705                 2710                 2715             


Ser Phe  Arg Ser Asn Glu Leu  Ser Trp Met Ser Phe  Ala Ser Phe 
    2720                 2725                 2730             


His Val  Arg Lys Lys Thr His  Ile Gln Leu Gln Phe  Gln Pro Leu 
    2735                 2740                 2745             


Ala Ala  Asp Gly Ile Leu Phe  Tyr Ala Ala Gln His  Leu Lys Ala 
    2750                 2755                 2760             


Gln Ser  Gly Asp Phe Leu Cys  Ile Ser Leu Val Asn  Ser Ser Val 
    2765                 2770                 2775             


Gln Leu  Arg Tyr Asn Leu Gly  Asp Arg Thr Ile Ile  Leu Glu Thr 
    2780                 2785                 2790             


Leu Gln  Lys Val Thr Ile Asn  Gly Ser Thr Trp His  Ile Ile Lys 
    2795                 2800                 2805             


Ala Gly  Arg Val Gly Ala Glu  Gly Tyr Leu Asp Leu  Asp Gly Ile 
    2810                 2815                 2820             


Asn Val  Thr Glu Lys Ala Ser  Thr Lys Met Ser Ser  Leu Asp Thr 
    2825                 2830                 2835             


Asn Thr  Asp Phe Tyr Ile Gly  Gly Val Ser Ser Leu  Asn Leu Val 
    2840                 2845                 2850             


Asn Pro  Met Ala Ile Glu Asn  Glu Pro Val Gly Phe  Gln Gly Cys 
    2855                 2860                 2865             


Ile Arg  Gln Val Ile Ile Asn  Asn Gln Glu Leu Gln  Leu Thr Glu 
    2870                 2875                 2880             


Phe Gly  Ala Lys Gly Gly Ser  Asn Val Gly Asp Cys  Asp Gly Thr 
    2885                 2890                 2895             


Ala Cys  Gly Tyr Asn Thr Cys  Arg Asn Gly Gly Glu  Cys Thr Val 
    2900                 2905                 2910             


Asn Gly  Thr Thr Phe Ser Cys  Arg Cys Leu Pro Asp  Trp Ala Gly 
    2915                 2920                 2925             


Asn Thr  Cys Asn Gln Ser Val  Ser Cys Leu Asn Asn  Leu Cys Leu 
    2930                 2935                 2940             


His Gln  Ser Leu Cys Ile Pro  Asp Gln Ser Phe Ser  Tyr Ser Cys 
    2945                 2950                 2955             


Leu Cys  Thr Leu Gly Trp Val  Gly Arg Tyr Cys Glu  Asn Lys Thr 
    2960                 2965                 2970             


Ser Phe  Ser Thr Ala Lys Phe  Met Gly Asn Ser Tyr  Ile Lys Tyr 
    2975                 2980                 2985             


Ile Asp  Pro Asn Tyr Arg Met  Arg Asn Leu Gln Phe  Thr Thr Ile 
    2990                 2995                 3000             


Ser Leu  Asn Phe Ser Thr Thr  Lys Thr Glu Gly Leu  Ile Val Trp 
    3005                 3010                 3015             


Met Gly  Ile Ala Gln Asn Glu  Glu Asn Asp Phe Leu  Ala Ile Gly 
    3020                 3025                 3030             


Leu His  Asn Gln Thr Leu Lys  Ile Ala Val Asn Leu  Gly Glu Arg 
    3035                 3040                 3045             


Ile Ser  Val Pro Met Ser Tyr  Asn Asn Gly Thr Phe  Cys Cys Asn 
    3050                 3055                 3060             


Lys Trp  His His Val Val Val  Ile Gln Asn Gln Thr  Leu Ile Lys 
    3065                 3070                 3075             


Ala Tyr  Ile Asn Asn Ser Leu  Ile Leu Ser Glu Asp  Ile Asp Pro 
    3080                 3085                 3090             


His Lys  Asn Phe Val Ala Leu  Asn Tyr Asp Gly Ile  Cys Tyr Leu 
    3095                 3100                 3105             


Gly Gly  Phe Glu Tyr Gly Arg  Lys Val Asn Ile Val  Thr Gln Glu 
    3110                 3115                 3120             


Ile Phe  Lys Thr Asn Phe Val  Gly Lys Ile Lys Asp  Val Val Phe 
    3125                 3130                 3135             


Phe Gln  Glu Pro Lys Asn Ile  Glu Leu Ile Lys Leu  Glu Gly Tyr 
    3140                 3145                 3150             


Asn Val  Tyr Asp Gly Asp Glu  Gln Asn Glu Val Thr  
    3155                 3160                 3165 


<210>  160
<211>  716
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FAM161 CENTROSOMAL PROTEIN A (FAM161A), ISOFORM 1 
<Accession No.: NP_001188472.1>

<400>  160

Met Ala Thr Ser His Arg Val Ala Lys Leu Val Ala Ser Ser Leu Gln 
1               5                   10                  15      


Thr Pro Val Asn Pro Ile Thr Gly Ala Arg Val Ala Gln Tyr Glu Arg 
            20                  25                  30          


Glu Asp Pro Leu Lys Ala Leu Ala Ala Ala Glu Ala Ile Leu Glu Asp 
        35                  40                  45              


Glu Glu Glu Glu Lys Val Ala Gln Pro Ala Gly Ala Ser Ala Asp Leu 
    50                  55                  60                  


Asn Thr Ser Phe Ser Gly Val Asp Glu His Ala Pro Ile Ser Tyr Glu 
65                  70                  75                  80  


Asp Phe Val Asn Phe Pro Asp Ile His His Ser Asn Glu Glu Tyr Phe 
                85                  90                  95      


Lys Lys Val Glu Glu Leu Lys Ala Ala His Ile Glu Thr Met Ala Lys 
            100                 105                 110         


Leu Glu Lys Met Tyr Gln Asp Lys Leu His Leu Lys Glu Val Gln Pro 
        115                 120                 125             


Val Val Ile Arg Glu Asp Ser Leu Ser Asp Ser Ser Arg Ser Val Ser 
    130                 135                 140                 


Glu Lys Asn Ser Tyr His Pro Val Ser Leu Met Thr Ser Phe Ser Glu 
145                 150                 155                 160 


Pro Asp Leu Gly Gln Ser Ser Ser Leu Tyr Val Ser Ser Ser Glu Glu 
                165                 170                 175     


Glu Leu Pro Asn Leu Glu Lys Glu Tyr Pro Arg Lys Asn Arg Met Met 
            180                 185                 190         


Thr Tyr Ala Lys Glu Leu Ile Asn Asn Met Trp Thr Asp Phe Cys Val 
        195                 200                 205             


Glu Asp Tyr Ile Arg Cys Lys Asp Thr Gly Phe His Ala Ala Glu Lys 
    210                 215                 220                 


Arg Arg Lys Lys Arg Lys Glu Trp Val Pro Thr Ile Thr Val Pro Glu 
225                 230                 235                 240 


Pro Phe Gln Met Met Ile Arg Glu Gln Lys Lys Lys Glu Glu Ser Met 
                245                 250                 255     


Lys Ser Lys Ser Asp Ile Glu Met Val His Lys Ala Leu Lys Lys Gln 
            260                 265                 270         


Glu Glu Asp Pro Glu Tyr Lys Lys Lys Phe Arg Ala Asn Pro Val Pro 
        275                 280                 285             


Ala Ser Val Phe Leu Pro Leu Tyr His Asp Leu Val Lys Gln Lys Glu 
    290                 295                 300                 


Glu Arg Arg Arg Ser Leu Lys Glu Lys Ser Lys Glu Ala Leu Leu Ala 
305                 310                 315                 320 


Ser Gln Lys Pro Phe Lys Phe Ile Ala Arg Glu Glu Gln Lys Arg Ala 
                325                 330                 335     


Ala Arg Glu Lys Gln Leu Arg Asp Phe Leu Lys Tyr Lys Lys Lys Thr 
            340                 345                 350         


Asn Arg Phe Lys Ala Arg Pro Ile Pro Arg Ser Thr Tyr Gly Ser Thr 
        355                 360                 365             


Thr Asn Asp Lys Leu Lys Glu Glu Glu Leu Tyr Arg Asn Leu Arg Thr 
    370                 375                 380                 


Gln Leu Arg Ala Gln Glu His Leu Gln Asn Ser Ser Pro Leu Pro Cys 
385                 390                 395                 400 


Arg Ser Ala Cys Gly Cys Arg Asn Pro Arg Cys Pro Glu Gln Ala Val 
                405                 410                 415     


Lys Leu Lys Cys Lys His Lys Val Arg Cys Pro Thr Pro Asp Phe Glu 
            420                 425                 430         


Asp Leu Pro Glu Arg Tyr Gln Lys His Leu Ser Glu His Lys Ser Pro 
        435                 440                 445             


Lys Leu Leu Thr Val Cys Lys Pro Phe Asp Leu His Ala Ser Pro His 
    450                 455                 460                 


Ala Ser Ile Lys Arg Glu Lys Ile Leu Ala Asp Ile Glu Ala Asp Glu 
465                 470                 475                 480 


Glu Asn Leu Lys Glu Thr Arg Trp Pro Tyr Leu Ser Pro Arg Arg Lys 
                485                 490                 495     


Ser Pro Val Arg Cys Ala Gly Val Asn Pro Val Pro Cys Asn Cys Asn 
            500                 505                 510         


Pro Pro Val Pro Thr Val Ser Ser Arg Gly Arg Glu Gln Ala Val Arg 
        515                 520                 525             


Arg Ser Leu Glu Glu Lys Lys Met Leu Glu Glu Glu Arg Asn Arg Ile 
    530                 535                 540                 


Leu Thr Lys Gln Lys Gln Arg Met Lys Glu Leu Gln Lys Leu Leu Thr 
545                 550                 555                 560 


Thr Arg Ala Lys Ala Tyr Asp Ser His Gln Ser Leu Ala Gln Ile Ser 
                565                 570                 575     


Lys Ser Arg Val Lys Cys Leu Arg Lys Ser Glu Lys Glu Arg Met Arg 
            580                 585                 590         


Glu Tyr Gln Arg Glu Leu Glu Glu Arg Glu Glu Lys Leu Lys Lys Arg 
        595                 600                 605             


Pro Leu Leu Phe Glu Arg Val Ala Gln Lys Asn Ala Arg Met Ala Ala 
    610                 615                 620                 


Glu Lys His Tyr Ser Asn Thr Leu Lys Ala Leu Gly Ile Ser Asp Glu 
625                 630                 635                 640 


Phe Val Ser Lys Lys Gly Gln Ser Gly Lys Val Leu Glu Tyr Phe Asn 
                645                 650                 655     


Asn Gln Glu Thr Lys Ser Val Thr Glu Asp Lys Glu Ser Phe Asn Glu 
            660                 665                 670         


Glu Glu Lys Ile Glu Glu Arg Glu Asn Gly Glu Glu Asn Tyr Phe Ile 
        675                 680                 685             


Asp Thr Asn Ser Gln Asp Ser Tyr Lys Glu Lys Asp Glu Ala Asn Glu 
    690                 695                 700                 


Glu Ser Glu Glu Glu Lys Ser Val Glu Glu Ser His 
705                 710                 715     


<210>  161
<211>  660
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FAM161 CENTROSOMAL PROTEIN A (FAM161A), ISOFORM 2 
<Accession No.: NP_115556.2>

<400>  161

Met Ala Thr Ser His Arg Val Ala Lys Leu Val Ala Ser Ser Leu Gln 
1               5                   10                  15      


Thr Pro Val Asn Pro Ile Thr Gly Ala Arg Val Ala Gln Tyr Glu Arg 
            20                  25                  30          


Glu Asp Pro Leu Lys Ala Leu Ala Ala Ala Glu Ala Ile Leu Glu Asp 
        35                  40                  45              


Glu Glu Glu Glu Lys Val Ala Gln Pro Ala Gly Ala Ser Ala Asp Leu 
    50                  55                  60                  


Asn Thr Ser Phe Ser Gly Val Asp Glu His Ala Pro Ile Ser Tyr Glu 
65                  70                  75                  80  


Asp Phe Val Asn Phe Pro Asp Ile His His Ser Asn Glu Glu Tyr Phe 
                85                  90                  95      


Lys Lys Val Glu Glu Leu Lys Ala Ala His Ile Glu Thr Met Ala Lys 
            100                 105                 110         


Leu Glu Lys Met Tyr Gln Asp Lys Leu His Leu Lys Glu Val Gln Pro 
        115                 120                 125             


Val Val Ile Arg Glu Asp Ser Leu Ser Asp Ser Ser Arg Ser Val Ser 
    130                 135                 140                 


Glu Lys Asn Ser Tyr His Pro Val Ser Leu Met Thr Ser Phe Ser Glu 
145                 150                 155                 160 


Pro Asp Leu Gly Gln Ser Ser Ser Leu Tyr Val Ser Ser Ser Glu Glu 
                165                 170                 175     


Glu Leu Pro Asn Leu Glu Lys Glu Tyr Pro Arg Lys Asn Arg Met Met 
            180                 185                 190         


Thr Tyr Ala Lys Glu Leu Ile Asn Asn Met Trp Thr Asp Phe Cys Val 
        195                 200                 205             


Glu Asp Tyr Ile Arg Cys Lys Asp Thr Gly Phe His Ala Ala Glu Lys 
    210                 215                 220                 


Arg Arg Lys Lys Arg Lys Glu Trp Val Pro Thr Ile Thr Val Pro Glu 
225                 230                 235                 240 


Pro Phe Gln Met Met Ile Arg Glu Gln Lys Lys Lys Glu Glu Ser Met 
                245                 250                 255     


Lys Ser Lys Ser Asp Ile Glu Met Val His Lys Ala Leu Lys Lys Gln 
            260                 265                 270         


Glu Glu Asp Pro Glu Tyr Lys Lys Lys Phe Arg Ala Asn Pro Val Pro 
        275                 280                 285             


Ala Ser Val Phe Leu Pro Leu Tyr His Asp Leu Val Lys Gln Lys Glu 
    290                 295                 300                 


Glu Arg Arg Arg Ser Leu Lys Glu Lys Ser Lys Glu Ala Leu Leu Ala 
305                 310                 315                 320 


Ser Gln Lys Pro Phe Lys Phe Ile Ala Arg Glu Glu Gln Lys Arg Ala 
                325                 330                 335     


Ala Arg Glu Lys Gln Leu Arg Asp Phe Leu Lys Tyr Lys Lys Lys Thr 
            340                 345                 350         


Asn Arg Phe Lys Ala Arg Pro Ile Pro Arg Ser Thr Tyr Gly Ser Thr 
        355                 360                 365             


Thr Asn Asp Lys Leu Lys Glu Glu Glu Leu Tyr Arg Asn Leu Arg Thr 
    370                 375                 380                 


Gln Leu Arg Ala Gln Glu His Leu Gln Asn Ser Ser Pro Leu Pro Cys 
385                 390                 395                 400 


Arg Ser Ala Cys Gly Cys Arg Asn Pro Arg Cys Pro Glu Gln Ala Val 
                405                 410                 415     


Lys Leu Lys Cys Lys His Lys Val Arg Cys Pro Thr Pro Asp Phe Glu 
            420                 425                 430         


Asp Leu Pro Glu Arg Tyr Gln Lys His Leu Ser Glu His Lys Ser Pro 
        435                 440                 445             


Lys Leu Leu Thr Val Cys Lys Pro Phe Asp Leu His Ala Ser Pro His 
    450                 455                 460                 


Ala Ser Ile Lys Arg Glu Lys Ile Leu Ala Asp Ile Glu Ala Asp Glu 
465                 470                 475                 480 


Glu Asn Leu Lys Glu Thr Arg Trp Pro Tyr Leu Ser Pro Arg Arg Lys 
                485                 490                 495     


Ser Pro Val Arg Cys Ala Gly Val Asn Pro Val Pro Cys Asn Cys Asn 
            500                 505                 510         


Pro Pro Val Pro Thr Val Ser Ser Arg Gly Arg Glu Gln Ala Val Arg 
        515                 520                 525             


Lys Ser Glu Lys Glu Arg Met Arg Glu Tyr Gln Arg Glu Leu Glu Glu 
    530                 535                 540                 


Arg Glu Glu Lys Leu Lys Lys Arg Pro Leu Leu Phe Glu Arg Val Ala 
545                 550                 555                 560 


Gln Lys Asn Ala Arg Met Ala Ala Glu Lys His Tyr Ser Asn Thr Leu 
                565                 570                 575     


Lys Ala Leu Gly Ile Ser Asp Glu Phe Val Ser Lys Lys Gly Gln Ser 
            580                 585                 590         


Gly Lys Val Leu Glu Tyr Phe Asn Asn Gln Glu Thr Lys Ser Val Thr 
        595                 600                 605             


Glu Asp Lys Glu Ser Phe Asn Glu Glu Glu Lys Ile Glu Glu Arg Glu 
    610                 615                 620                 


Asn Gly Glu Glu Asn Tyr Phe Ile Asp Thr Asn Ser Gln Asp Ser Tyr 
625                 630                 635                 640 


Lys Glu Lys Asp Glu Ala Asn Glu Glu Ser Glu Glu Glu Lys Ser Val 
                645                 650                 655     


Glu Glu Ser His 
            660 


<210>  162
<211>  999
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MER PROTO-ONCOGENE, TYROSINE KINASE (MERTK); 
<Accession No.: Q12866.2>

<400>  162

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  163
<211>  853
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PHOSPHODIESTERASE 6B (PDE6B) <Accession No.: AAH00249.1>

<400>  163

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Asp His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser Ser 
        835                 840                 845             


Thr Cys Cys Ile Leu 
    850             


<210>  164
<211>  803
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PHOSPHODIESTERASE 6B (PDE6B), ISOFORM CRA_A <Accession 
No.: EAW82661.1>

<400>  164

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Arg Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Ala Ile Leu Ser Phe Pro Arg Arg Asp Pro Ala His Val Arg Pro Thr 
785                 790                 795                 800 


Ala Glu Gln 
            


<210>  165
<211>  640
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PHOSPHODIESTERASE 6B (PDE6B), ISOFORM CRA_B <Accession 
No.: EAW82662.1>

<400>  165

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Val Leu Val Arg Phe Leu Phe Ser Ile Ser Lys Gly Tyr Arg Arg 
        355                 360                 365             


Ile Thr Tyr His Asn Trp Arg His Gly Phe Asn Val Ala Gln Thr Met 
    370                 375                 380                 


Phe Thr Leu Leu Met Thr Gly Lys Leu Lys Ser Tyr Tyr Thr Asp Leu 
385                 390                 395                 400 


Glu Ala Phe Ala Met Val Thr Ala Gly Leu Cys His Asp Ile Asp His 
                405                 410                 415     


Arg Gly Thr Asn Asn Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala 
            420                 425                 430         


Lys Leu His Gly Ser Ser Ile Leu Glu Arg His His Leu Glu Phe Gly 
        435                 440                 445             


Lys Phe Leu Leu Ser Glu Glu Thr Leu Asn Ile Tyr Gln Asn Leu Asn 
    450                 455                 460                 


Arg Arg Gln His Glu His Val Ile His Leu Met Asp Ile Ala Ile Ile 
465                 470                 475                 480 


Ala Thr Asp Leu Ala Leu Tyr Phe Lys Lys Arg Ala Met Phe Gln Lys 
                485                 490                 495     


Ile Val Asp Glu Ser Lys Asn Tyr Gln Asp Lys Lys Ser Trp Val Glu 
            500                 505                 510         


Tyr Leu Ser Leu Glu Thr Thr Arg Lys Glu Ile Val Met Ala Met Met 
        515                 520                 525             


Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln 
    530                 535                 540                 


Ser Lys Val Ala Leu Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp 
545                 550                 555                 560 


Leu Glu Arg Thr Val Leu Asp Gln Gln Pro Ile Pro Met Met Asp Arg 
                565                 570                 575     


Asn Lys Ala Ala Glu Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe 
            580                 585                 590         


Val Cys Thr Phe Val Tyr Lys Ala Ser Gly Ser Arg Val Arg His Arg 
        595                 600                 605             


Asn Leu Gln Trp Arg Pro Ser Thr Gln Val Phe Asn Leu Leu Tyr Pro 
    610                 615                 620                 


Val Ser Thr Val Pro Trp Asp Pro Met Ala Pro Ser Ile Phe Thr His 
625                 630                 635                 640 


<210>  166
<211>  865
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROMININ 1 (PROM1) <Accession No.: O43490.1>

<400>  166

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  167
<211>  856
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROMININ 1 (PROM1), ISOFORM CRA_A <Accession No.: EAW92750.1>

<400>  167

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830         


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845             


Val Met Thr Ser Pro Ser Gln His 
    850                 855     


<210>  168
<211>  81
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROMININ 1 (PROM1), ISOFORM CRA_B <Accession No.: EAW92751.1>

<400>  168

Met Phe His Leu Glu Met Ala Cys Lys Ser Asn His Arg Glu Thr Cys 
1               5                   10                  15      


Val Thr Pro Ser Asp Lys Phe Lys Arg Glu Arg Glu Ile Leu Arg Glu 
            20                  25                  30          


Lys Cys Cys Ser Phe Lys Ser Gly Val Val Leu Thr Asp Ala Asn Tyr 
        35                  40                  45              


Gly Val Gln Phe Asn Arg Val Phe Cys Cys Ile Arg Ile Asn Ile Asn 
    50                  55                  60                  


Trp Ser Ala Ala Asn Met Ser Ile Ile Arg Leu Val Ser Ser Val Leu 
65                  70                  75                  80  


Lys 
    


<210>  169
<211>  865
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROMININ 1 (PROM1), ISOFORM CRA_C <Accession No.: EAW92752.1>

<400>  169

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  170
<211>  860
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PHOSPHODIESTERASE 6A (PDE6A) <Accession No.: AAH35909.1>

<400>  170

Met Gly Glu Val Thr Ala Glu Glu Val Glu Lys Phe Leu Asp Ser Asn 
1               5                   10                  15      


Ile Gly Phe Ala Lys Gln Tyr Tyr Asn Leu His Tyr Arg Ala Lys Leu 
            20                  25                  30          


Ile Ser Asp Leu Leu Gly Ala Lys Glu Ala Ala Val Asp Phe Ser Asn 
        35                  40                  45              


Tyr His Ser Pro Ser Ser Met Glu Glu Ser Glu Ile Ile Phe Asp Leu 
    50                  55                  60                  


Leu Arg Asp Phe Gln Glu Asn Leu Gln Thr Glu Lys Cys Ile Phe Asn 
65                  70                  75                  80  


Val Met Lys Lys Leu Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu 
                85                  90                  95      


Phe Met Tyr Arg Thr Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu 
            100                 105                 110         


Phe Asn Val His Lys Asp Ala Val Leu Glu Asp Cys Leu Val Met Pro 
        115                 120                 125             


Asp Gln Glu Ile Val Phe Pro Leu Asp Met Gly Ile Val Gly His Val 
    130                 135                 140                 


Ala His Ser Lys Lys Ile Ala Asn Val Pro Asn Thr Glu Glu Asp Glu 
145                 150                 155                 160 


His Phe Cys Asp Phe Val Asp Ile Leu Thr Glu Tyr Lys Thr Lys Asn 
                165                 170                 175     


Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala Ile Ile 
            180                 185                 190         


Met Ala Val Asn Lys Val Asp Gly Ser His Phe Thr Lys Arg Asp Glu 
        195                 200                 205             


Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu Ile Met Lys Val 
    210                 215                 220                 


Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Ile 
225                 230                 235                 240 


Leu Leu Trp Ser Gly Ser Lys Val Phe Glu Glu Leu Thr Asp Ile Glu 
                245                 250                 255     


Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ala Phe Leu Asn Cys 
            260                 265                 270         


Asp Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Gln Lys Glu Phe 
        275                 280                 285             


Phe Asp Val Trp Pro Val Leu Met Gly Glu Val Pro Pro Tyr Ser Gly 
    290                 295                 300                 


Pro Arg Thr Pro Asp Gly Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp 
305                 310                 315                 320 


Tyr Ile Leu His Gly Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro 
                325                 330                 335     


Pro Asp His Trp Ala Leu Val Ser Gly Leu Pro Ala Tyr Val Ala Gln 
            340                 345                 350         


Asn Gly Leu Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe 
        355                 360                 365             


Ala Phe Gln Lys Glu Pro Leu Asp Glu Ser Gly Trp Met Ile Lys Asn 
    370                 375                 380                 


Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 
385                 390                 395                 400 


Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met Asp 
                405                 410                 415     


Glu Thr Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Leu 
            420                 425                 430         


Asn Pro Asp Thr Tyr Glu Ser Met Asn Lys Leu Glu Asn Arg Lys Asp 
        435                 440                 445             


Ile Phe Gln Asp Ile Val Lys Tyr His Val Lys Cys Asp Asn Glu Glu 
    450                 455                 460                 


Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr Gly Lys Glu Pro Trp 
465                 470                 475                 480 


Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile Leu Gln Ala Glu Leu Pro 
                485                 490                 495     


Asp Ala Asp Lys Tyr Glu Ile Asn Lys Phe His Phe Ser Asp Leu Pro 
            500                 505                 510         


Leu Thr Glu Leu Glu Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu 
        515                 520                 525             


Leu Lys Val Val Asp Lys Phe His Ile Pro Gln Glu Ala Leu Val Arg 
    530                 535                 540                 


Phe Met Tyr Ser Leu Ser Lys Gly Tyr Arg Lys Ile Thr Tyr His Asn 
545                 550                 555                 560 


Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val 
                565                 570                 575     


Thr Gly Lys Leu Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met 
            580                 585                 590         


Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn 
        595                 600                 605             


Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser 
    610                 615                 620                 


Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 
625                 630                 635                 640 


Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His Glu 
                645                 650                 655     


His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala 
            660                 665                 670         


Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln Ser 
        675                 680                 685             


Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu Glu 
    690                 695                 700                 


Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp 
705                 710                 715                 720 


Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala Leu 
                725                 730                 735     


Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val 
            740                 745                 750         


Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp Glu 
        755                 760                 765             


Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val 
    770                 775                 780                 


Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu Asp 
785                 790                 795                 800 


Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr 
                805                 810                 815     


Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln Ser 
            820                 825                 830         


Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser Pro 
        835                 840                 845             


Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
    850                 855                 860 


<210>  171
<211>  269
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PHOSPHODIESTERASE 6A (PDE6A), ISOFORM CRA_A <Accession 
No.: EAW61756.1>

<400>  171

Met Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn 
1               5                   10                  15      


Asn Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly 
            20                  25                  30          


Ser Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu 
        35                  40                  45              


Arg Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His 
    50                  55                  60                  


Glu His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu 
65                  70                  75                  80  


Ala Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln 
                85                  90                  95      


Ser Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu 
            100                 105                 110         


Glu Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys 
        115                 120                 125             


Asp Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala 
    130                 135                 140                 


Leu Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr 
145                 150                 155                 160 


Val Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp 
                165                 170                 175     


Glu Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe 
            180                 185                 190         


Val Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu 
        195                 200                 205             


Asp Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu 
    210                 215                 220                 


Tyr Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln 
225                 230                 235                 240 


Ser Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser 
                245                 250                 255     


Pro Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
            260                 265                 


<210>  172
<211>  860
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PHOSPHODIESTERASE 6A (PDE6A), ISOFORM CRA_B 
<Accession No.: EAW61757.1>

<400>  172

Met Gly Glu Val Thr Ala Glu Glu Val Glu Lys Phe Leu Asp Ser Asn 
1               5                   10                  15      


Ile Gly Phe Ala Lys Gln Tyr Tyr Asn Leu His Tyr Arg Ala Lys Leu 
            20                  25                  30          


Ile Ser Asp Leu Leu Gly Ala Lys Glu Ala Ala Val Asp Phe Ser Asn 
        35                  40                  45              


Tyr His Ser Pro Ser Ser Met Glu Glu Ser Glu Ile Ile Phe Asp Leu 
    50                  55                  60                  


Leu Arg Asp Phe Gln Glu Asn Leu Gln Thr Glu Lys Cys Ile Phe Asn 
65                  70                  75                  80  


Val Met Lys Lys Leu Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu 
                85                  90                  95      


Phe Met Tyr Arg Thr Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu 
            100                 105                 110         


Phe Asn Val His Lys Asp Ala Val Leu Glu Asp Cys Leu Val Met Pro 
        115                 120                 125             


Asp Gln Glu Ile Val Phe Pro Leu Asp Met Gly Ile Val Gly His Val 
    130                 135                 140                 


Ala His Ser Lys Lys Ile Ala Asn Val Pro Asn Thr Glu Glu Asp Glu 
145                 150                 155                 160 


His Phe Cys Asp Phe Val Asp Ile Leu Thr Glu Tyr Lys Thr Lys Asn 
                165                 170                 175     


Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala Ile Ile 
            180                 185                 190         


Met Ala Val Asn Lys Val Asp Gly Ser His Phe Thr Lys Arg Asp Glu 
        195                 200                 205             


Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu Ile Met Lys Val 
    210                 215                 220                 


Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Ile 
225                 230                 235                 240 


Leu Leu Trp Ser Gly Ser Lys Val Phe Glu Glu Leu Thr Asp Ile Glu 
                245                 250                 255     


Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ala Phe Leu Asn Cys 
            260                 265                 270         


Asp Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Gln Lys Glu Phe 
        275                 280                 285             


Phe Asp Val Trp Pro Val Leu Met Gly Glu Val Pro Pro Tyr Ser Gly 
    290                 295                 300                 


Pro Arg Thr Pro Asp Gly Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp 
305                 310                 315                 320 


Tyr Ile Leu His Gly Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro 
                325                 330                 335     


Pro Asp His Trp Ala Leu Val Ser Gly Leu Pro Ala Tyr Val Ala Gln 
            340                 345                 350         


Asn Gly Leu Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe 
        355                 360                 365             


Ala Phe Gln Lys Glu Pro Leu Asp Glu Ser Gly Trp Met Ile Lys Asn 
    370                 375                 380                 


Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 
385                 390                 395                 400 


Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met Asp 
                405                 410                 415     


Glu Thr Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Leu 
            420                 425                 430         


Asn Pro Asp Thr Tyr Glu Ser Met Asn Lys Leu Glu Asn Arg Lys Asp 
        435                 440                 445             


Ile Phe Gln Asp Ile Val Lys Tyr His Val Lys Cys Asp Asn Glu Glu 
    450                 455                 460                 


Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr Gly Lys Glu Pro Trp 
465                 470                 475                 480 


Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile Leu Gln Ala Glu Leu Pro 
                485                 490                 495     


Asp Ala Asp Lys Tyr Glu Ile Asn Lys Phe His Phe Ser Asp Leu Pro 
            500                 505                 510         


Leu Thr Glu Leu Glu Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu 
        515                 520                 525             


Leu Lys Val Val Asp Lys Phe His Ile Pro Gln Glu Ala Leu Val Arg 
    530                 535                 540                 


Phe Met Tyr Ser Leu Ser Lys Gly Tyr Arg Lys Ile Thr Tyr His Asn 
545                 550                 555                 560 


Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val 
                565                 570                 575     


Thr Gly Lys Leu Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met 
            580                 585                 590         


Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn 
        595                 600                 605             


Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser 
    610                 615                 620                 


Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 
625                 630                 635                 640 


Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His Glu 
                645                 650                 655     


His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala 
            660                 665                 670         


Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln Ser 
        675                 680                 685             


Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu Glu 
    690                 695                 700                 


Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp 
705                 710                 715                 720 


Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala Leu 
                725                 730                 735     


Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val 
            740                 745                 750         


Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp Glu 
        755                 760                 765             


Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val 
    770                 775                 780                 


Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu Asp 
785                 790                 795                 800 


Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr 
                805                 810                 815     


Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln Ser 
            820                 825                 830         


Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser Pro 
        835                 840                 845             


Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
    850                 855                 860 


<210>  173
<211>  1241
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2 (IMPG2)
 <Accession No.: EAW79803.1>

<400>  173

Met Ile Met Phe Pro Leu Phe Gly Lys Ile Ser Leu Gly Ile Leu Ile 
1               5                   10                  15      


Phe Val Leu Ile Glu Gly Asp Phe Pro Ser Leu Thr Ala Gln Thr Tyr 
            20                  25                  30          


Leu Ser Ile Glu Glu Ile Gln Glu Pro Lys Ser Ala Val Ser Phe Leu 
        35                  40                  45              


Leu Pro Glu Glu Ser Thr Asp Leu Ser Leu Ala Thr Lys Lys Lys Gln 
    50                  55                  60                  


Pro Leu Asp Arg Arg Glu Thr Glu Arg Gln Trp Leu Ile Arg Arg Arg 
65                  70                  75                  80  


Arg Ser Ile Leu Phe Pro Asn Gly Val Lys Ile Cys Pro Asp Glu Ser 
                85                  90                  95      


Val Ala Glu Ala Val Ala Asn His Val Lys Tyr Phe Lys Val Arg Val 
            100                 105                 110         


Cys Gln Glu Ala Val Trp Glu Ala Phe Arg Thr Phe Trp Asp Arg Leu 
        115                 120                 125             


Pro Gly Arg Glu Glu Tyr His Tyr Trp Met Asn Leu Cys Glu Asp Gly 
    130                 135                 140                 


Val Thr Ser Ile Phe Glu Met Gly Thr Asn Phe Ser Glu Ser Val Glu 
145                 150                 155                 160 


His Arg Ser Leu Ile Met Lys Lys Leu Thr Tyr Ala Lys Glu Thr Val 
                165                 170                 175     


Ser Ser Ser Glu Leu Ser Ser Pro Val Pro Val Gly Asp Thr Ser Thr 
            180                 185                 190         


Leu Gly Asp Thr Thr Leu Ser Val Pro His Pro Glu Val Asp Ala Tyr 
        195                 200                 205             


Glu Gly Ala Ser Glu Ser Ser Leu Glu Arg Pro Glu Glu Ser Ile Ser 
    210                 215                 220                 


Asn Glu Ile Glu Asn Val Ile Glu Glu Ala Thr Lys Pro Ala Gly Glu 
225                 230                 235                 240 


Gln Ile Ala Glu Phe Ser Ile His Leu Leu Gly Lys Gln Tyr Arg Glu 
                245                 250                 255     


Glu Leu Gln Asp Ser Ser Ser Phe His His Gln His Leu Glu Glu Glu 
            260                 265                 270         


Phe Ile Ser Glu Val Glu Asn Ala Phe Thr Gly Leu Pro Gly Tyr Lys 
        275                 280                 285             


Glu Ile Arg Val Leu Glu Phe Arg Ser Pro Lys Glu Asn Asp Ser Gly 
    290                 295                 300                 


Val Asp Val Tyr Tyr Ala Val Thr Phe Asn Gly Glu Ala Ile Ser Asn 
305                 310                 315                 320 


Thr Thr Trp Asp Leu Ile Ser Leu His Ser Asn Lys Val Glu Asn His 
                325                 330                 335     


Gly Leu Val Glu Leu Asp Asp Lys Pro Thr Val Val Tyr Thr Ile Ser 
            340                 345                 350         


Asn Phe Arg Asp Tyr Ile Ala Glu Thr Leu Gln Gln Asn Phe Leu Leu 
        355                 360                 365             


Gly Asn Ser Ser Leu Asn Pro Asp Pro Asp Ser Leu Gln Leu Ile Asn 
    370                 375                 380                 


Val Arg Gly Val Leu Arg His Gln Thr Glu Asp Leu Val Trp Asn Thr 
385                 390                 395                 400 


Gln Ser Ser Ser Leu Gln Ala Thr Pro Ser Ser Ile Leu Asp Asn Thr 
                405                 410                 415     


Phe Gln Ala Ala Trp Pro Ser Ala Asp Glu Ser Ile Thr Ser Ser Ile 
            420                 425                 430         


Pro Pro Leu Asp Phe Ser Ser Gly Pro Pro Ser Ala Thr Gly Arg Glu 
        435                 440                 445             


Leu Trp Ser Glu Ser Pro Leu Gly Asp Leu Val Ser Thr His Lys Leu 
    450                 455                 460                 


Ala Phe Pro Ser Lys Met Gly Leu Ser Ser Ser Pro Glu Val Leu Glu 
465                 470                 475                 480 


Val Ser Ser Leu Thr Leu His Ser Val Thr Pro Ala Val Leu Gln Thr 
                485                 490                 495     


Gly Leu Pro Val Ala Ser Glu Glu Arg Thr Ser Gly Ser His Leu Val 
            500                 505                 510         


Glu Asp Gly Leu Ala Asn Val Glu Glu Ser Glu Asp Phe Leu Ser Ile 
        515                 520                 525             


Asp Ser Leu Pro Ser Ser Ser Phe Thr Gln Pro Val Pro Lys Glu Thr 
    530                 535                 540                 


Ile Pro Ser Met Glu Asp Ser Asp Val Ser Leu Thr Ser Ser Pro Tyr 
545                 550                 555                 560 


Leu Thr Ser Ser Ile Pro Phe Gly Leu Asp Ser Leu Thr Ser Lys Val 
                565                 570                 575     


Lys Asp Gln Leu Lys Val Ser Pro Phe Leu Pro Asp Ala Ser Met Glu 
            580                 585                 590         


Lys Glu Leu Ile Phe Asp Gly Gly Leu Gly Ser Gly Ser Gly Gln Lys 
        595                 600                 605             


Val Asp Leu Ile Thr Trp Pro Trp Ser Glu Thr Ser Ser Glu Lys Ser 
    610                 615                 620                 


Ala Glu Pro Leu Ser Lys Pro Trp Leu Glu Asp Asp Asp Ser Leu Leu 
625                 630                 635                 640 


Pro Ala Glu Ile Glu Asp Lys Lys Leu Val Leu Val Asp Lys Met Asp 
                645                 650                 655     


Ser Thr Asp Gln Ile Ser Lys His Ser Lys Tyr Glu His Asp Asp Arg 
            660                 665                 670         


Ser Ile His Phe Pro Glu Glu Glu Pro Leu Ser Gly Pro Ala Val Pro 
        675                 680                 685             


Ile Phe Ala Asp Thr Ala Ala Glu Ser Ala Ser Leu Thr Leu Pro Lys 
    690                 695                 700                 


His Ile Ser Glu Val Pro Gly Val Asp Asp Tyr Ser Val Thr Lys Ala 
705                 710                 715                 720 


Pro Leu Ile Leu Thr Ser Val Ala Ile Ser Ala Ser Thr Asp Lys Ser 
                725                 730                 735     


Asp Gln Ala Asp Ala Ile Leu Arg Glu Asp Met Glu Gln Ile Thr Glu 
            740                 745                 750         


Ser Ser Asn Tyr Glu Trp Phe Asp Ser Glu Val Ser Met Val Lys Pro 
        755                 760                 765             


Asp Met Gln Thr Leu Trp Thr Ile Leu Pro Glu Ser Glu Arg Val Trp 
    770                 775                 780                 


Thr Arg Thr Ser Ser Leu Glu Lys Leu Ser Arg Asp Ile Leu Ala Ser 
785                 790                 795                 800 


Thr Pro Gln Ser Ala Asp Arg Leu Trp Leu Ser Val Thr Gln Ser Thr 
                805                 810                 815     


Lys Leu Pro Pro Thr Thr Ile Ser Thr Leu Leu Glu Asp Glu Val Ile 
            820                 825                 830         


Met Gly Val Gln Asp Ile Ser Leu Glu Leu Asp Arg Ile Gly Thr Asp 
        835                 840                 845             


Tyr Tyr Gln Pro Glu Gln Val Gln Glu Gln Asn Gly Lys Val Gly Ser 
    850                 855                 860                 


Tyr Val Glu Met Ser Thr Ser Val His Ser Thr Glu Met Val Ser Val 
865                 870                 875                 880 


Ala Trp Pro Thr Glu Gly Gly Asp Asp Leu Ser Tyr Thr Gln Thr Ser 
                885                 890                 895     


Gly Ala Leu Val Val Phe Phe Ser Leu Arg Val Thr Asn Met Met Phe 
            900                 905                 910         


Ser Glu Asp Leu Phe Asn Lys Asn Ser Leu Glu Tyr Lys Ala Leu Glu 
        915                 920                 925             


Gln Arg Phe Leu Glu Leu Leu Val Pro Tyr Leu Gln Ser Asn Leu Thr 
    930                 935                 940                 


Gly Phe Gln Asn Leu Glu Ile Leu Asn Phe Arg Asn Gly Ser Ile Val 
945                 950                 955                 960 


Val Asn Ser Arg Met Lys Phe Ala Asn Ser Val Pro Pro Asn Val Asn 
                965                 970                 975     


Asn Ala Val Tyr Met Ile Leu Glu Asp Phe Cys Thr Thr Ala Tyr Asn 
            980                 985                 990         


Thr Met Asn Leu Ala Ile Asp Lys  Tyr Ser Leu Asp Val  Glu Ser Gly 
        995                 1000                 1005             


Asp Glu  Ala Asn Pro Cys Lys  Phe Gln Ala Cys Asn  Glu Phe Ser 
    1010                 1015                 1020             


Glu Cys  Leu Val Asn Pro Trp  Ser Gly Glu Ala Lys  Cys Arg Cys 
    1025                 1030                 1035             


Phe Pro  Gly Tyr Leu Ser Val  Glu Glu Arg Pro Cys  Gln Ser Leu 
    1040                 1045                 1050             


Cys Asp  Leu Gln Pro Asp Phe  Cys Leu Asn Asp Gly  Lys Cys Asp 
    1055                 1060                 1065             


Ile Met  Pro Gly His Gly Ala  Ile Cys Arg Cys Arg  Val Gly Glu 
    1070                 1075                 1080             


Asn Trp  Trp Tyr Arg Gly Lys  His Cys Glu Glu Phe  Val Ser Glu 
    1085                 1090                 1095             


Pro Val  Ile Ile Gly Ile Thr  Ile Ala Ser Val Val  Gly Leu Leu 
    1100                 1105                 1110             


Val Ile  Phe Ser Ala Ile Ile  Tyr Phe Phe Ile Arg  Thr Leu Gln 
    1115                 1120                 1125             


Ala His  His Asp Arg Ser Glu  Arg Glu Ser Pro Phe  Ser Gly Ser 
    1130                 1135                 1140             


Ser Arg  Gln Pro Asp Ser Leu  Ser Ser Ile Glu Asn  Ala Val Lys 
    1145                 1150                 1155             


Tyr Asn  Pro Val Tyr Glu Ser  His Arg Ala Gly Cys  Glu Lys Tyr 
    1160                 1165                 1170             


Glu Gly  Pro Tyr Pro Gln His  Pro Phe Tyr Ser Ser  Ala Ser Gly 
    1175                 1180                 1185             


Asp Val  Ile Gly Gly Leu Ser  Arg Glu Glu Ile Arg  Gln Met Tyr 
    1190                 1195                 1200             


Glu Ser  Ser Glu Leu Ser Arg  Glu Glu Ile Gln Glu  Arg Met Arg 
    1205                 1210                 1215             


Val Leu  Glu Leu Tyr Ala Asn  Asp Pro Glu Phe Ala  Ala Phe Val 
    1220                 1225                 1230             


Arg Glu  Gln Gln Val Glu Glu  Val 
    1235                 1240     


<210>  174
<211>  623
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MALE GERM CELL ASSOCIATED KINASE (MAK) <Accession 
No.: AAN16405.1>

<400>  174

Met Asn Arg Tyr Thr Thr Met Arg Gln Leu Gly Asp Gly Thr Tyr Gly 
1               5                   10                  15      


Ser Val Leu Met Gly Lys Ser Asn Glu Ser Gly Glu Leu Val Ala Ile 
            20                  25                  30          


Lys Arg Met Lys Arg Lys Phe Tyr Ser Trp Asp Glu Cys Met Asn Leu 
        35                  40                  45              


Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Ile Lys 
    50                  55                  60                  


Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
65                  70                  75                  80  


Tyr Met Lys Glu Asn Leu Tyr Gln Leu Met Lys Asp Arg Asn Lys Leu 
                85                  90                  95      


Phe Pro Glu Ser Val Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
            100                 105                 110         


Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Met Lys Pro 
        115                 120                 125             


Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Glu Leu Arg Ser Gln Pro Pro Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Ser Val 
                165                 170                 175     


Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Ser Ile Met Ala Glu 
            180                 185                 190         


Leu Tyr Met Leu Arg Pro Leu Phe Pro Gly Thr Ser Glu Val Asp Glu 
        195                 200                 205             


Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Ser Asp Trp 
    210                 215                 220                 


Pro Glu Gly Tyr Gln Leu Ala Ser Ser Met Asn Phe Arg Phe Pro Gln 
225                 230                 235                 240 


Cys Val Pro Ile Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Asn Glu 
                245                 250                 255     


Ala Ile Gln Leu Met Thr Glu Met Leu Asn Trp Asp Pro Lys Lys Arg 
            260                 265                 270         


Pro Thr Ala Ser Gln Ala Leu Lys His Pro Tyr Phe Gln Val Gly Gln 
        275                 280                 285             


Val Leu Gly Pro Ser Ser Asn His Leu Glu Ser Lys Gln Ser Leu Asn 
    290                 295                 300                 


Lys Gln Leu Gln Pro Leu Glu Ser Lys Pro Ser Leu Val Glu Val Glu 
305                 310                 315                 320 


Pro Lys Pro Leu Pro Asp Ile Ile Asp Gln Val Val Gly Gln Pro Gln 
                325                 330                 335     


Pro Lys Thr Ser Gln Gln Pro Leu Gln Pro Ile Gln Pro Pro Gln Asn 
            340                 345                 350         


Leu Ser Val Gln Gln Pro Pro Lys Gln Gln Ser Gln Glu Lys Pro Pro 
        355                 360                 365             


Gln Thr Leu Phe Pro Ser Ile Val Lys Asn Met Pro Thr Lys Pro Asn 
    370                 375                 380                 


Gly Thr Leu Ser His Lys Ser Gly Arg Arg Arg Trp Gly Gln Thr Ile 
385                 390                 395                 400 


Phe Lys Ser Gly Asp Ser Trp Glu Glu Leu Glu Asp Tyr Asp Phe Gly 
                405                 410                 415     


Ala Ser His Ser Lys Lys Pro Ser Met Gly Val Phe Lys Glu Lys Arg 
            420                 425                 430         


Lys Lys Asp Ser Pro Phe Arg Leu Pro Glu Pro Val Pro Ser Gly Ser 
        435                 440                 445             


Asn His Ser Thr Gly Glu Asn Lys Ser Leu Pro Ala Val Thr Ser Leu 
    450                 455                 460                 


Lys Ser Asp Ser Glu Leu Ser Thr Ala Pro Thr Ser Lys Gln Tyr Tyr 
465                 470                 475                 480 


Leu Lys Gln Ser Arg Tyr Leu Pro Gly Val Asn Pro Lys Lys Val Ser 
                485                 490                 495     


Leu Ile Ala Ser Gly Lys Glu Ile Asn Pro His Thr Trp Ser Asn Gln 
            500                 505                 510         


Leu Phe Pro Lys Ser Leu Gly Pro Val Gly Ala Glu Leu Ala Phe Lys 
        515                 520                 525             


Arg Ser Asn Ala Gly Asn Leu Gly Ser Tyr Ala Thr Tyr Asn Gln Ser 
    530                 535                 540                 


Gly Tyr Ile Pro Ser Phe Leu Lys Lys Glu Val Gln Ser Ala Gly Gln 
545                 550                 555                 560 


Arg Ile His Leu Ala Pro Leu Asn Ala Thr Ala Ser Glu Tyr Thr Trp 
                565                 570                 575     


Asn Thr Lys Thr Gly Arg Gly Gln Phe Ser Gly Arg Thr Tyr Asn Pro 
            580                 585                 590         


Thr Ala Lys Asn Leu Asn Ile Val Asn Arg Ala Gln Pro Ile Pro Ser 
        595                 600                 605             


Val His Gly Arg Thr Asp Trp Val Ala Lys Tyr Gly Gly His Arg 
    610                 615                 620             


<210>  175
<211>  648
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MALE GERM CELL ASSOCIATED KINASE (MAK); RETINAL-ENRICHED 
ISOFORM <Accession No.: AEL29206.1>

<400>  175

Met Asn Arg Tyr Thr Thr Met Arg Gln Leu Gly Asp Gly Thr Tyr Gly 
1               5                   10                  15      


Ser Val Leu Met Gly Lys Ser Asn Glu Ser Gly Glu Leu Val Ala Ile 
            20                  25                  30          


Lys Arg Met Lys Arg Lys Phe Tyr Ser Trp Asp Glu Cys Met Asn Leu 
        35                  40                  45              


Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Ile Lys 
    50                  55                  60                  


Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
65                  70                  75                  80  


Tyr Met Lys Glu Asn Leu Tyr Gln Leu Met Lys Asp Arg Asn Lys Leu 
                85                  90                  95      


Phe Pro Glu Ser Val Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
            100                 105                 110         


Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Met Lys Pro 
        115                 120                 125             


Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Glu Leu Arg Ser Gln Pro Pro Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Ser Val 
                165                 170                 175     


Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Ser Ile Met Ala Glu 
            180                 185                 190         


Leu Tyr Met Leu Arg Pro Leu Phe Pro Gly Thr Ser Glu Val Asp Glu 
        195                 200                 205             


Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Ser Asp Trp 
    210                 215                 220                 


Pro Glu Gly Tyr Gln Leu Ala Ser Ser Met Asn Phe Arg Phe Pro Gln 
225                 230                 235                 240 


Cys Val Pro Ile Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Asn Glu 
                245                 250                 255     


Ala Ile Gln Leu Met Thr Glu Met Leu Asn Trp Asp Pro Lys Lys Arg 
            260                 265                 270         


Pro Thr Ala Ser Gln Ala Leu Lys His Pro Tyr Phe Gln Val Gly Gln 
        275                 280                 285             


Val Leu Gly Pro Ser Ser Asn His Leu Glu Ser Lys Gln Ser Leu Asn 
    290                 295                 300                 


Lys Gln Leu Gln Pro Leu Glu Ser Lys Pro Ser Leu Val Glu Val Glu 
305                 310                 315                 320 


Pro Lys Pro Leu Pro Asp Ile Ile Asp Gln Val Val Gly Gln Pro Gln 
                325                 330                 335     


Pro Lys Thr Ser Gln Gln Pro Leu Gln Pro Ile Gln Pro Pro Gln Asn 
            340                 345                 350         


Leu Ser Val Gln Gln Pro Pro Lys Gln Gln Ser Gln Glu Lys Pro Pro 
        355                 360                 365             


Gln Thr Leu Phe Pro Ser Ile Val Lys Asn Met Pro Thr Lys Pro Asn 
    370                 375                 380                 


Gly Thr Leu Ser His Lys Ser Gly Arg Arg Arg Trp Gly Gln Thr Ile 
385                 390                 395                 400 


Phe Lys Ser Gly Asp Ser Trp Glu Glu Leu Glu Asp Tyr Asp Phe Gly 
                405                 410                 415     


Ala Ser His Ser Lys Lys Pro Ser Met Gly Val Phe Lys Glu Lys Arg 
            420                 425                 430         


Lys Lys Asp Ser Pro Phe Arg Leu Pro Glu Pro Val Pro Ser Gly Ser 
        435                 440                 445             


Asn His Ser Thr Gly Glu Asn Lys Ser Leu Pro Ala Val Thr Ser Leu 
    450                 455                 460                 


Lys Ser Asp Ser Glu Leu Ser Thr Ala Pro Thr Ser Lys Gln Tyr Tyr 
465                 470                 475                 480 


Leu Lys Gln Ser Arg Tyr Leu Pro Gly Val Asn Pro Lys Lys Val Ser 
                485                 490                 495     


Leu Ile Ala Ser Gly Lys Glu Ile Asn Pro His Thr Trp Ser Asn Gln 
            500                 505                 510         


Leu Phe Pro Lys Ser Leu Gly Pro Val Gly Ala Glu Leu Ala Phe Lys 
        515                 520                 525             


Arg Ser Asn Ala Glu Glu Ser Ile Ile Lys Pro Ile Glu Lys Leu Ser 
    530                 535                 540                 


Cys Asn Glu Thr Phe Pro Glu Lys Leu Glu Asp Pro Gln Gly Asn Leu 
545                 550                 555                 560 


Gly Ser Tyr Ala Thr Tyr Asn Gln Ser Gly Tyr Ile Pro Ser Phe Leu 
                565                 570                 575     


Lys Lys Glu Val Gln Ser Ala Gly Gln Arg Ile His Leu Ala Pro Leu 
            580                 585                 590         


Asn Ala Thr Ala Ser Glu Tyr Thr Trp Asn Thr Lys Thr Gly Arg Gly 
        595                 600                 605             


Gln Phe Ser Gly Arg Thr Tyr Asn Pro Thr Ala Lys Asn Leu Asn Ile 
    610                 615                 620                 


Val Asn Arg Ala Gln Pro Ile Pro Ser Val His Gly Arg Thr Asp Trp 
625                 630                 635                 640 


Val Ala Lys Tyr Gly Gly His Arg 
                645             


<210>  176
<211>  1462
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTRAFLAGELLAR TRANSPORT 140 (IFT140) <Accession 
No.: NP_055529.2>

<400>  176

Met Ala Leu Tyr Tyr Asp His Gln Ile Glu Ala Pro Asp Ala Ala Gly 
1               5                   10                  15      


Ser Pro Ser Phe Ile Ser Trp His Pro Val His Pro Phe Leu Ala Val 
            20                  25                  30          


Ala Tyr Ile Ser Thr Thr Ser Thr Gly Ser Val Asp Ile Tyr Leu Glu 
        35                  40                  45              


Gln Gly Glu Cys Val Pro Asp Thr His Val Glu Arg Pro Phe Arg Val 
    50                  55                  60                  


Ala Ser Leu Cys Trp His Pro Thr Arg Leu Val Leu Ala Val Gly Trp 
65                  70                  75                  80  


Glu Thr Gly Glu Val Thr Val Phe Asn Lys Gln Asp Lys Glu Gln His 
                85                  90                  95      


Thr Met Pro Leu Thr His Thr Ala Asp Ile Thr Val Leu Arg Trp Ser 
            100                 105                 110         


Pro Ser Gly Asn Cys Leu Leu Ser Gly Asp Arg Leu Gly Val Leu Leu 
        115                 120                 125             


Leu Trp Arg Leu Asp Gln Arg Gly Arg Val Gln Gly Thr Pro Leu Leu 
    130                 135                 140                 


Lys His Glu Tyr Gly Lys His Leu Thr His Cys Ile Phe Arg Leu Pro 
145                 150                 155                 160 


Pro Pro Gly Glu Asp Leu Val Gln Leu Ala Lys Ala Ala Val Ser Gly 
                165                 170                 175     


Asp Glu Lys Ala Leu Asp Met Phe Asn Trp Lys Lys Ser Ser Ser Gly 
            180                 185                 190         


Ser Leu Leu Lys Met Gly Ser His Glu Gly Leu Leu Phe Phe Val Ser 
        195                 200                 205             


Leu Met Asp Gly Thr Val His Tyr Val Asp Glu Lys Gly Lys Thr Thr 
    210                 215                 220                 


Gln Val Val Ser Ala Asp Ser Thr Ile Gln Met Leu Phe Tyr Met Glu 
225                 230                 235                 240 


Lys Arg Glu Ala Leu Val Val Val Thr Glu Asn Leu Arg Leu Ser Leu 
                245                 250                 255     


Tyr Thr Val Pro Pro Glu Gly Lys Ala Glu Glu Val Met Lys Val Lys 
            260                 265                 270         


Leu Ser Gly Lys Thr Gly Arg Arg Ala Asp Ile Ala Leu Ile Glu Gly 
        275                 280                 285             


Ser Leu Leu Val Met Ala Val Gly Glu Ala Ala Leu Arg Phe Trp Asp 
    290                 295                 300                 


Ile Glu Arg Gly Glu Asn Tyr Ile Leu Ser Pro Asp Glu Lys Phe Gly 
305                 310                 315                 320 


Phe Glu Lys Gly Glu Asn Met Asn Cys Val Cys Tyr Cys Lys Val Lys 
                325                 330                 335     


Gly Leu Leu Ala Ala Gly Thr Asp Arg Gly Arg Val Ala Met Trp Arg 
            340                 345                 350         


Lys Val Pro Asp Phe Leu Gly Ser Pro Gly Ala Glu Gly Lys Asp Arg 
        355                 360                 365             


Trp Ala Leu Gln Thr Pro Thr Glu Leu Gln Gly Asn Ile Thr Gln Ile 
    370                 375                 380                 


Gln Trp Gly Ser Arg Lys Asn Leu Leu Ala Val Asn Ser Val Ile Ser 
385                 390                 395                 400 


Val Ala Ile Leu Ser Glu Arg Ala Met Ser Ser His Phe His Gln Gln 
                405                 410                 415     


Val Ala Ala Met Gln Val Ser Pro Ser Leu Leu Asn Val Cys Phe Leu 
            420                 425                 430         


Ser Thr Gly Val Ala His Ser Leu Arg Thr Asp Met His Ile Ser Gly 
        435                 440                 445             


Val Phe Ala Thr Lys Asp Ala Val Ala Val Trp Asn Gly Arg Gln Val 
    450                 455                 460                 


Ala Ile Phe Glu Leu Ser Gly Ala Ala Ile Arg Ser Ala Gly Thr Phe 
465                 470                 475                 480 


Leu Cys Glu Thr Pro Val Leu Ala Met His Glu Glu Asn Val Tyr Thr 
                485                 490                 495     


Val Glu Ser Asn Arg Val Gln Val Arg Thr Trp Gln Gly Thr Val Lys 
            500                 505                 510         


Gln Leu Leu Leu Phe Ser Glu Thr Glu Gly Asn Pro Cys Phe Leu Asp 
        515                 520                 525             


Ile Cys Gly Asn Phe Leu Val Val Gly Thr Asp Leu Ala His Phe Lys 
    530                 535                 540                 


Ser Phe Asp Leu Ser Arg Arg Glu Ala Lys Ala His Cys Ser Cys Arg 
545                 550                 555                 560 


Ser Leu Ala Glu Leu Val Pro Gly Val Gly Gly Ile Ala Ser Leu Arg 
                565                 570                 575     


Cys Ser Ser Ser Gly Ser Thr Ile Ser Ile Leu Pro Ser Lys Ala Asp 
            580                 585                 590         


Asn Ser Pro Asp Ser Lys Ile Cys Phe Tyr Asp Val Glu Met Asp Thr 
        595                 600                 605             


Val Thr Val Phe Asp Phe Lys Thr Gly Gln Ile Asp Arg Arg Glu Thr 
    610                 615                 620                 


Leu Ser Phe Asn Glu Gln Glu Thr Asn Lys Ser His Leu Phe Val Asp 
625                 630                 635                 640 


Glu Gly Leu Lys Asn Tyr Val Pro Val Asn His Phe Trp Asp Gln Ser 
                645                 650                 655     


Glu Pro Arg Leu Phe Val Cys Glu Ala Val Gln Glu Thr Pro Arg Ser 
            660                 665                 670         


Gln Pro Gln Ser Ala Asn Gly Gln Pro Gln Asp Gly Arg Ala Gly Pro 
        675                 680                 685             


Ala Ala Asp Val Leu Ile Leu Ser Phe Phe Ile Ser Glu Glu His Gly 
    690                 695                 700                 


Phe Leu Leu His Glu Ser Phe Pro Arg Pro Ala Thr Ser His Ser Leu 
705                 710                 715                 720 


Leu Gly Met Glu Val Pro Tyr Tyr Tyr Phe Thr Arg Lys Pro Glu Glu 
                725                 730                 735     


Ala Asp Arg Glu Asp Glu Val Glu Pro Gly Cys His His Ile Pro Gln 
            740                 745                 750         


Met Val Ser Arg Arg Pro Leu Arg Asp Phe Val Gly Leu Glu Asp Cys 
        755                 760                 765             


Asp Lys Ala Thr Arg Asp Ala Met Leu His Phe Ser Phe Phe Val Thr 
    770                 775                 780                 


Ile Gly Asp Met Asp Glu Ala Phe Lys Ser Ile Lys Leu Ile Lys Ser 
785                 790                 795                 800 


Glu Ala Val Trp Glu Asn Met Ala Arg Met Cys Val Lys Thr Gln Arg 
                805                 810                 815     


Leu Asp Val Ala Lys Val Cys Leu Gly Asn Met Gly His Ala Arg Gly 
            820                 825                 830         


Ala Arg Ala Leu Arg Glu Ala Glu Gln Glu Pro Glu Leu Glu Ala Arg 
        835                 840                 845             


Val Ala Val Leu Ala Thr Gln Leu Gly Met Leu Glu Asp Ala Glu Gln 
    850                 855                 860                 


Leu Tyr Arg Lys Cys Lys Arg His Asp Leu Leu Asn Lys Phe Tyr Gln 
865                 870                 875                 880 


Ala Ala Gly Arg Trp Gln Glu Ala Leu Gln Val Ala Glu His His Asp 
                885                 890                 895     


Arg Val His Leu Arg Ser Thr Tyr His Arg Tyr Ala Gly His Leu Glu 
            900                 905                 910         


Ala Ser Ala Asp Cys Ser Arg Ala Leu Ser Tyr Tyr Glu Lys Ser Asp 
        915                 920                 925             


Thr His Arg Phe Glu Val Pro Arg Met Leu Ser Glu Asp Leu Pro Ser 
    930                 935                 940                 


Leu Glu Leu Tyr Val Asn Lys Met Lys Asp Lys Thr Leu Trp Arg Trp 
945                 950                 955                 960 


Trp Ala Gln Tyr Leu Glu Ser Gln Gly Glu Met Asp Ala Ala Leu His 
                965                 970                 975     


Tyr Tyr Glu Leu Ala Arg Asp His Phe Ser Leu Val Arg Ile His Cys 
            980                 985                 990         


Phe Gln Gly Asn Val Gln Lys Ala  Ala Gln Ile Ala Asn  Glu Thr Gly 
        995                 1000                 1005             


Asn Leu  Ala Ala Ser Tyr His  Leu Ala Arg Gln Tyr  Glu Ser Gln 
    1010                 1015                 1020             


Glu Glu  Val Gly Gln Ala Val  His Phe Tyr Thr Arg  Ala Gln Ala 
    1025                 1030                 1035             


Phe Lys  Asn Ala Ile Arg Leu  Cys Lys Glu Asn Gly  Leu Asp Asp 
    1040                 1045                 1050             


Gln Leu  Met Asn Leu Ala Leu  Leu Ser Ser Pro Glu  Asp Met Ile 
    1055                 1060                 1065             


Glu Ala  Ala Arg Tyr Tyr Glu  Glu Lys Gly Val Gln  Met Asp Arg 
    1070                 1075                 1080             


Ala Val  Met Leu Tyr His Lys  Ala Gly His Phe Ser  Lys Ala Leu 
    1085                 1090                 1095             


Glu Leu  Ala Phe Ala Thr Gln  Gln Phe Val Ala Leu  Gln Leu Ile 
    1100                 1105                 1110             


Ala Glu  Asp Leu Asp Glu Thr  Ser Asp Pro Ala Leu  Leu Ala Arg 
    1115                 1120                 1125             


Cys Ser  Asp Phe Phe Ile Glu  His Ser Gln Tyr Glu  Arg Ala Val 
    1130                 1135                 1140             


Glu Leu  Leu Leu Ala Ala Arg  Lys Tyr Gln Glu Ala  Leu Gln Leu 
    1145                 1150                 1155             


Cys Leu  Gly Gln Asn Met Ser  Ile Thr Glu Glu Met  Ala Glu Lys 
    1160                 1165                 1170             


Met Thr  Val Ala Lys Asp Ser  Ser Asp Leu Pro Glu  Glu Ser Arg 
    1175                 1180                 1185             


Arg Glu  Leu Leu Glu Gln Ile  Ala Asp Cys Cys Met  Arg Gln Gly 
    1190                 1195                 1200             


Ser Tyr  His Leu Ala Thr Lys  Lys Tyr Thr Gln Ala  Gly Asn Lys 
    1205                 1210                 1215             


Leu Lys  Ala Met Arg Ala Leu  Leu Lys Ser Gly Asp  Thr Glu Lys 
    1220                 1225                 1230             


Ile Thr  Phe Phe Ala Ser Val  Ser Arg Gln Lys Glu  Ile Tyr Ile 
    1235                 1240                 1245             


Met Ala  Ala Asn Tyr Leu Gln  Ser Leu Asp Trp Arg  Lys Glu Pro 
    1250                 1255                 1260             


Glu Ile  Met Lys Asn Ile Ile  Gly Phe Tyr Thr Lys  Gly Arg Ala 
    1265                 1270                 1275             


Leu Asp  Leu Leu Ala Gly Phe  Tyr Asp Ala Cys Ala  Gln Val Glu 
    1280                 1285                 1290             


Ile Asp  Glu Tyr Gln Asn Tyr  Asp Lys Ala His Gly  Ala Leu Thr 
    1295                 1300                 1305             


Glu Ala  Tyr Lys Cys Leu Ala  Lys Ala Lys Ala Lys  Ser Pro Leu 
    1310                 1315                 1320             


Asp Gln  Glu Thr Arg Leu Ala  Gln Leu Gln Ser Arg  Met Ala Leu 
    1325                 1330                 1335             


Val Lys  Arg Phe Ile Gln Ala  Arg Arg Thr Tyr Thr  Glu Asp Pro 
    1340                 1345                 1350             


Lys Glu  Ser Ile Lys Gln Cys  Glu Leu Leu Leu Glu  Glu Pro Asp 
    1355                 1360                 1365             


Leu Asp  Ser Thr Ile Arg Ile  Gly Asp Val Tyr Gly  Phe Leu Val 
    1370                 1375                 1380             


Glu His  Tyr Val Arg Lys Glu  Glu Tyr Gln Thr Ala  Tyr Arg Phe 
    1385                 1390                 1395             


Leu Glu  Glu Met Arg Arg Arg  Leu Pro Leu Ala Asn  Met Ser Tyr 
    1400                 1405                 1410             


Tyr Val  Ser Pro Gln Ala Val  Asp Ala Val His Arg  Gly Leu Gly 
    1415                 1420                 1425             


Leu Pro  Leu Pro Arg Thr Val  Pro Glu Gln Val Arg  His Asn Ser 
    1430                 1435                 1440             


Met Glu  Asp Ala Arg Glu Leu  Asp Glu Glu Val Val  Glu Glu Ala 
    1445                 1450                 1455             


Asp Asp  Asp Pro 
    1460         


<210>  177
<211>  480
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HTRA SERINE PEPTIDASE 1 (HTRA1) <Accession No.: EAW49312.1>

<400>  177

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro 
            20                  25                  30          


Leu Ala Ala Gly Cys Pro Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro 
        35                  40                  45              


Gln Pro Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys 
    50                  55                  60                  


Cys Glu Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu 
65                  70                  75                  80  


Gly Pro Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro 
                85                  90                  95      


Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys 
            100                 105                 110         


Ala Ser Ser Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn 
        115                 120                 125             


Leu Cys Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg 
    130                 135                 140                 


Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu 
145                 150                 155                 160 


Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val 
                165                 170                 175     


Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu 
            180                 185                 190         


Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile 
        195                 200                 205             


Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn 
    210                 215                 220                 


Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala 
225                 230                 235                 240 


Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile 
                245                 250                 255     


Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu 
            260                 265                 270         


Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu 
        275                 280                 285             


Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly 
    290                 295                 300                 


Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp 
305                 310                 315                 320 


Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp 
                325                 330                 335     


Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser 
            340                 345                 350         


Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His 
        355                 360                 365             


Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly 
    370                 375                 380                 


Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp 
385                 390                 395                 400 


Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu 
                405                 410                 415     


Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp 
            420                 425                 430         


Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val 
        435                 440                 445             


Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg 
    450                 455                 460                 


Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
465                 470                 475                 480 


<210>  178
<211>  585
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 1 <Accession No.: NP_004174.1>

<400>  178

Met Thr Ile Thr Tyr Thr Ser Gln Val Ala Asn Ala Arg Leu Gly Ser 
1               5                   10                  15      


Phe Ser Arg Leu Leu Leu Cys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Gly Glu Phe Leu Ile Phe Leu Leu Cys Tyr Tyr Ile Ile Arg Phe 
        35                  40                  45              


Ile Tyr Arg Leu Ala Leu Thr Glu Glu Gln Gln Leu Met Phe Glu Lys 
    50                  55                  60                  


Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile Pro Ile Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg Trp Trp Asn Gln 
                85                  90                  95      


Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser Leu Val Ser Gly 
            100                 105                 110         


Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His Leu Val Gln Ala 
145                 150                 155                 160 


Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu Lys Leu Ser Leu 
                165                 170                 175     


Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe Ala Asn Leu Ser 
            180                 185                 190         


Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro Ile Leu Leu Gln 
        195                 200                 205             


Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln Cys Gly His Leu 
    210                 215                 220                 


Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu Leu Asp Leu Val 
            260                 265                 270         


Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr Val Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met Glu Pro Asp Met 
                325                 330                 335     


Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr Ala Ala Ser Ala 
            340                 345                 350         


Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe Asn Ile Ser Leu 
        355                 360                 365             


Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu Asp Glu Glu Asp 
    370                 375                 380                 


Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu Gln Ser His Asp 
385                 390                 395                 400 


His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu Leu Trp Pro Lys 
                405                 410                 415     


Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn His Lys Ala Ala 
            420                 425                 430         


Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala Trp Lys Leu Lys 
        435                 440                 445             


Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln Arg Pro Gly Tyr 
    450                 455                 460                 


Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro Met Phe Phe Pro 
465                 470                 475                 480 


Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val Thr Gly Ile Asp 
                485                 490                 495     


Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly Ala Lys Lys Ser 
            500                 505                 510         


Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met Glu His Pro Glu 
        515                 520                 525             


Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn Leu Thr Asp Met 
    530                 535                 540                 


Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu Glu Gln Ser Pro 
545                 550                 555                 560 


Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp Pro Tyr Trp Ala 
                565                 570                 575     


Leu Glu Asn Arg Asp Glu Ala His Ser 
            580                 585 


<210>  179
<211>  604
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 2 <Accession No.: NP_001132915.1>

<400>  179

Met Phe Glu Lys Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile 
1               5                   10                  15      


Pro Ile Ser Phe Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg 
            20                  25                  30          


Trp Trp Asn Gln Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser 
        35                  40                  45              


Leu Val Ser Gly Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu 
    50                  55                  60                  


Arg Arg Thr Leu Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu 
65                  70                  75                  80  


Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His 
                85                  90                  95      


Leu Val Gln Ala Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu 
            100                 105                 110         


Lys Leu Ser Leu Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe 
        115                 120                 125             


Ala Asn Leu Ser Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro 
    130                 135                 140                 


Ile Leu Leu Gln Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln 
145                 150                 155                 160 


Cys Gly His Leu Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr 
                165                 170                 175     


Thr Gln Val Val Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu 
            180                 185                 190         


Val Gly Arg Gln Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu 
        195                 200                 205             


Leu Asp Leu Val Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr 
    210                 215                 220                 


Val Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu 
225                 230                 235                 240 


Asp Asp Asp Asp Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln 
                245                 250                 255     


Val Ser Leu Leu Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met 
            260                 265                 270         


Glu Pro Asp Met Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr 
        275                 280                 285             


Ala Ala Ser Ala Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe 
    290                 295                 300                 


Asn Ile Ser Leu Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu 
305                 310                 315                 320 


Asp Glu Glu Asp Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu 
                325                 330                 335     


Gln Ser His Asp His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu 
            340                 345                 350         


Leu Trp Pro Lys Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn 
        355                 360                 365             


His Lys Ala Ala Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala 
    370                 375                 380                 


Trp Lys Leu Lys Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln 
385                 390                 395                 400 


Arg Pro Gly Tyr Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro 
                405                 410                 415     


Met Phe Phe Pro Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val 
            420                 425                 430         


Thr Gly Ile Asp Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly 
        435                 440                 445             


Ala Lys Lys Ser Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met 
    450                 455                 460                 


Glu His Pro Glu Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn 
465                 470                 475                 480 


Leu Thr Asp Met Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu 
                485                 490                 495     


Glu Gln Ser Pro Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp 
            500                 505                 510         


Pro Tyr Trp Ala Leu Glu Asn Arg Ser Val Leu His Leu Asn Gln Gly 
        515                 520                 525             


His Cys Ile Ala Leu Cys Pro Thr Pro Ala Ser Leu Ala Leu Ser Leu 
    530                 535                 540                 


Pro Phe Leu His Asn Phe Leu Gly Phe His His Cys Gln Ser Thr Leu 
545                 550                 555                 560 


Asp Leu Arg Pro Ala Leu Ala Trp Gly Ile Tyr Leu Ala Thr Phe Thr 
                565                 570                 575     


Gly Ile Leu Gly Lys Cys Ser Gly Pro Phe Leu Thr Ser Pro Trp Tyr 
            580                 585                 590         


His Pro Glu Asp Phe Leu Gly Pro Gly Glu Gly Arg 
        595                 600                 


<210>  180
<211>  525
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 3 <Accession No.: ALQ33849.1>

<400>  180

Met Phe Glu Lys Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile 
1               5                   10                  15      


Pro Ile Ser Phe Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg 
            20                  25                  30          


Trp Trp Asn Gln Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser 
        35                  40                  45              


Leu Val Ser Gly Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu 
    50                  55                  60                  


Arg Arg Thr Leu Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu 
65                  70                  75                  80  


Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His 
                85                  90                  95      


Leu Val Gln Ala Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu 
            100                 105                 110         


Lys Leu Ser Leu Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe 
        115                 120                 125             


Ala Asn Leu Ser Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro 
    130                 135                 140                 


Ile Leu Leu Gln Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln 
145                 150                 155                 160 


Cys Gly His Leu Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr 
                165                 170                 175     


Thr Gln Val Val Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu 
            180                 185                 190         


Val Gly Arg Gln Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu 
        195                 200                 205             


Leu Asp Leu Val Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr 
    210                 215                 220                 


Val Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu 
225                 230                 235                 240 


Asp Asp Asp Asp Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln 
                245                 250                 255     


Val Ser Leu Leu Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met 
            260                 265                 270         


Glu Pro Asp Met Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr 
        275                 280                 285             


Ala Ala Ser Ala Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe 
    290                 295                 300                 


Asn Ile Ser Leu Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu 
305                 310                 315                 320 


Asp Glu Glu Asp Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu 
                325                 330                 335     


Gln Ser His Asp His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu 
            340                 345                 350         


Leu Trp Pro Lys Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn 
        355                 360                 365             


His Lys Ala Ala Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala 
    370                 375                 380                 


Trp Lys Leu Lys Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln 
385                 390                 395                 400 


Arg Pro Gly Tyr Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro 
                405                 410                 415     


Met Phe Phe Pro Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val 
            420                 425                 430         


Thr Gly Ile Asp Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly 
        435                 440                 445             


Ala Lys Lys Ser Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met 
    450                 455                 460                 


Glu His Pro Glu Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn 
465                 470                 475                 480 


Leu Thr Asp Met Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu 
                485                 490                 495     


Glu Gln Ser Pro Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp 
            500                 505                 510         


Pro Tyr Trp Ala Leu Glu Asn Arg Asp Glu Ala His Ser 
        515                 520                 525 


<210>  181
<211>  474
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 4 <Accession No.: NP_001287716.1>

<400>  181

Met Phe Glu Lys Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile 
1               5                   10                  15      


Pro Ile Ser Phe Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg 
            20                  25                  30          


Trp Trp Asn Gln Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser 
        35                  40                  45              


Leu Val Ser Gly Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu 
    50                  55                  60                  


Arg Arg Thr Leu Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu 
65                  70                  75                  80  


Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His 
                85                  90                  95      


Leu Val Gln Ala Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu 
            100                 105                 110         


Lys Leu Ser Leu Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe 
        115                 120                 125             


Ala Asn Leu Ser Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro 
    130                 135                 140                 


Ile Leu Leu Gln Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln 
145                 150                 155                 160 


Cys Gly His Leu Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr 
                165                 170                 175     


Thr Gln Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp 
            180                 185                 190         


Asp Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln Val Ser Leu 
        195                 200                 205             


Leu Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met Glu Pro Asp 
    210                 215                 220                 


Met Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr Ala Ala Ser 
225                 230                 235                 240 


Ala Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe Asn Ile Ser 
                245                 250                 255     


Leu Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu Asp Glu Glu 
            260                 265                 270         


Asp Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu Gln Ser His 
        275                 280                 285             


Asp His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu Leu Trp Pro 
    290                 295                 300                 


Lys Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn His Lys Ala 
305                 310                 315                 320 


Ala Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala Trp Lys Leu 
                325                 330                 335     


Lys Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln Arg Pro Gly 
            340                 345                 350         


Tyr Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro Met Phe Phe 
        355                 360                 365             


Pro Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val Thr Gly Ile 
    370                 375                 380                 


Asp Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly Ala Lys Lys 
385                 390                 395                 400 


Ser Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met Glu His Pro 
                405                 410                 415     


Glu Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn Leu Thr Asp 
            420                 425                 430         


Met Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu Glu Gln Ser 
        435                 440                 445             


Pro Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp Pro Tyr Trp 
    450                 455                 460                 


Ala Leu Glu Asn Arg Asp Glu Ala His Ser 
465                 470                 


<210>  182
<211>  558
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 5 <Accession No.: NP_001350520.1>

<400>  182

Met Ser Leu Val Ser Gly Phe Val Glu Gly Lys Asp Glu Gln Gly Arg 
1               5                   10                  15      


Leu Leu Arg Arg Thr Leu Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu 
            20                  25                  30          


Ile Leu Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala 
        35                  40                  45              


Gln His Leu Val Gln Ala Gly Phe Met Thr Pro Ala Glu His Lys Gln 
    50                  55                  60                  


Leu Glu Lys Leu Ser Leu Pro His Asn Met Phe Trp Val Pro Trp Val 
65                  70                  75                  80  


Trp Phe Ala Asn Leu Ser Met Lys Ala Trp Leu Gly Gly Arg Ile Arg 
                85                  90                  95      


Asp Pro Ile Leu Leu Gln Ser Leu Leu Asn Glu Met Asn Thr Leu Arg 
            100                 105                 110         


Thr Gln Cys Gly His Leu Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu 
        115                 120                 125             


Val Tyr Thr Gln Val Val Thr Val Ala Val Tyr Ser Phe Phe Leu Thr 
    130                 135                 140                 


Cys Leu Val Gly Arg Gln Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly 
145                 150                 155                 160 


His Glu Leu Asp Leu Val Val Pro Val Phe Thr Phe Leu Gln Phe Phe 
                165                 170                 175     


Phe Tyr Val Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe 
            180                 185                 190         


Gly Glu Asp Asp Asp Asp Phe Glu Thr Asn Trp Ile Val Asp Arg Asn 
        195                 200                 205             


Leu Gln Val Ser Leu Leu Ala Val Asp Glu Met His Gln Asp Leu Pro 
    210                 215                 220                 


Arg Met Glu Pro Asp Met Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro 
225                 230                 235                 240 


Tyr Thr Ala Ala Ser Ala Gln Phe Arg Arg Ala Ser Phe Met Gly Ser 
                245                 250                 255     


Thr Phe Asn Ile Ser Leu Asn Lys Glu Glu Met Glu Phe Gln Pro Asn 
            260                 265                 270         


Gln Glu Asp Glu Glu Asp Ala His Ala Gly Ile Ile Gly Arg Phe Leu 
        275                 280                 285             


Gly Leu Gln Ser His Asp His His Pro Pro Arg Ala Asn Ser Arg Thr 
    290                 295                 300                 


Lys Leu Leu Trp Pro Lys Arg Glu Ser Leu Leu His Glu Gly Leu Pro 
305                 310                 315                 320 


Lys Asn His Lys Ala Ala Lys Gln Asn Val Arg Gly Gln Glu Asp Asn 
                325                 330                 335     


Lys Ala Trp Lys Leu Lys Ala Val Asp Ala Phe Lys Ser Ala Pro Leu 
            340                 345                 350         


Tyr Gln Arg Pro Gly Tyr Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro 
        355                 360                 365             


Thr Pro Met Phe Phe Pro Leu Glu Pro Ser Ala Pro Ser Lys Leu His 
    370                 375                 380                 


Ser Val Thr Gly Ile Asp Thr Lys Asp Lys Ser Leu Lys Thr Val Ser 
385                 390                 395                 400 


Ser Gly Ala Lys Lys Ser Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala 
                405                 410                 415     


Leu Met Glu His Pro Glu Val Ser Gln Val Arg Arg Lys Thr Val Glu 
            420                 425                 430         


Phe Asn Leu Thr Asp Met Pro Glu Ile Pro Glu Asn His Leu Lys Glu 
        435                 440                 445             


Pro Leu Glu Gln Ser Pro Thr Asn Ile His Thr Thr Leu Lys Asp His 
    450                 455                 460                 


Met Asp Pro Tyr Trp Ala Leu Glu Asn Arg Ser Val Leu His Leu Asn 
465                 470                 475                 480 


Gln Gly His Cys Ile Ala Leu Cys Pro Thr Pro Ala Ser Leu Ala Leu 
                485                 490                 495     


Ser Leu Pro Phe Leu His Asn Phe Leu Gly Phe His His Cys Gln Ser 
            500                 505                 510         


Thr Leu Asp Leu Arg Pro Ala Leu Ala Trp Gly Ile Tyr Leu Ala Thr 
        515                 520                 525             


Phe Thr Gly Ile Leu Gly Lys Cys Ser Gly Pro Phe Leu Thr Ser Pro 
    530                 535                 540                 


Trp Tyr His Pro Glu Asp Phe Leu Gly Pro Gly Glu Gly Arg 
545                 550                 555             


<210>  183
<211>  435
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 6 <Accession No.: NP_001350521.1>

<400>  183

Met Thr Ile Thr Tyr Thr Ser Gln Val Ala Asn Ala Arg Leu Gly Ser 
1               5                   10                  15      


Phe Ser Arg Leu Leu Leu Cys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Gly Glu Phe Leu Ile Phe Leu Leu Cys Tyr Tyr Ile Ile Arg Phe 
        35                  40                  45              


Ile Tyr Arg Leu Ala Leu Thr Glu Glu Gln Gln Leu Met Phe Glu Lys 
    50                  55                  60                  


Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile Pro Ile Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg Trp Trp Asn Gln 
                85                  90                  95      


Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser Leu Val Ser Gly 
            100                 105                 110         


Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His Leu Val Gln Ala 
145                 150                 155                 160 


Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu Lys Leu Ser Leu 
                165                 170                 175     


Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe Ala Asn Leu Ser 
            180                 185                 190         


Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro Ile Leu Leu Gln 
        195                 200                 205             


Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln Cys Gly His Leu 
    210                 215                 220                 


Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu Leu Asp Leu Val 
            260                 265                 270         


Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr Val Gly Trp Leu 
        275                 280                 285             


Lys Val Gly Leu Ser Arg Ala Leu Leu Gly Trp Arg His Gly Gln Arg 
    290                 295                 300                 


Gly His Gly Gln Gln Leu Pro Glu Thr Arg Met Gln Cys Gln Glu Arg 
305                 310                 315                 320 


Lys Val Ser Arg Val Glu Ser Ser Gln Ala Trp Trp Arg Thr Pro Val 
                325                 330                 335     


Ile Pro Ala Thr Arg Glu Ala Glu Ala Gly Glu Ser Leu Glu Pro Gly 
            340                 345                 350         


Arg Arg Arg Leu Trp Trp Gln Ser Ser Ser Ser Thr Pro Leu Glu Arg 
        355                 360                 365             


Met Met Met Ile Leu Arg Pro Thr Gly Leu Ser Thr Gly Ile Cys Arg 
    370                 375                 380                 


Cys Pro Cys Trp Leu Trp Met Arg Cys Thr Arg Thr Cys Leu Gly Trp 
385                 390                 395                 400 


Ser Arg Thr Cys Thr Gly Ile Ser Pro Ser His Ser Pro Pro Thr Gln 
                405                 410                 415     


Leu Leu Pro Pro Ser Ser Val Glu Pro Pro Leu Trp Ala Pro Pro Ser 
            420                 425                 430         


Thr Ser Ala 
        435 


<210>  184
<211>  340
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 7 <Accession No.: NP_001350522.1>

<400>  184

Met His Gln Asp Leu Pro Arg Met Glu Pro Asp Met Tyr Trp Asn Lys 
1               5                   10                  15      


Pro Glu Pro Gln Pro Pro Tyr Thr Ala Ala Ser Ala Gln Phe Arg Arg 
            20                  25                  30          


Ala Ser Phe Met Gly Ser Thr Phe Asn Ile Ser Leu Asn Lys Glu Glu 
        35                  40                  45              


Met Glu Phe Gln Pro Asn Gln Glu Asp Glu Glu Asp Ala His Ala Gly 
    50                  55                  60                  


Ile Ile Gly Arg Phe Leu Gly Leu Gln Ser His Asp His His Pro Pro 
65                  70                  75                  80  


Arg Ala Asn Ser Arg Thr Lys Leu Leu Trp Pro Lys Arg Glu Ser Leu 
                85                  90                  95      


Leu His Glu Gly Leu Pro Lys Asn His Lys Ala Ala Lys Gln Asn Val 
            100                 105                 110         


Arg Gly Gln Glu Asp Asn Lys Ala Trp Lys Leu Lys Ala Val Asp Ala 
        115                 120                 125             


Phe Lys Ser Ala Pro Leu Tyr Gln Arg Pro Gly Tyr Tyr Ser Ala Pro 
    130                 135                 140                 


Gln Thr Pro Leu Ser Pro Thr Pro Met Phe Phe Pro Leu Glu Pro Ser 
145                 150                 155                 160 


Ala Pro Ser Lys Leu His Ser Val Thr Gly Ile Asp Thr Lys Asp Lys 
                165                 170                 175     


Ser Leu Lys Thr Val Ser Ser Gly Ala Lys Lys Ser Phe Glu Leu Leu 
            180                 185                 190         


Ser Glu Ser Asp Gly Ala Leu Met Glu His Pro Glu Val Ser Gln Val 
        195                 200                 205             


Arg Arg Lys Thr Val Glu Phe Asn Leu Thr Asp Met Pro Glu Ile Pro 
    210                 215                 220                 


Glu Asn His Leu Lys Glu Pro Leu Glu Gln Ser Pro Thr Asn Ile His 
225                 230                 235                 240 


Thr Thr Leu Lys Asp His Met Asp Pro Tyr Trp Ala Leu Glu Asn Arg 
                245                 250                 255     


Ser Val Leu His Leu Asn Gln Gly His Cys Ile Ala Leu Cys Pro Thr 
            260                 265                 270         


Pro Ala Ser Leu Ala Leu Ser Leu Pro Phe Leu His Asn Phe Leu Gly 
        275                 280                 285             


Phe His His Cys Gln Ser Thr Leu Asp Leu Arg Pro Ala Leu Ala Trp 
    290                 295                 300                 


Gly Ile Tyr Leu Ala Thr Phe Thr Gly Ile Leu Gly Lys Cys Ser Gly 
305                 310                 315                 320 


Pro Phe Leu Thr Ser Pro Trp Tyr His Pro Glu Asp Phe Leu Gly Pro 
                325                 330                 335     


Gly Glu Gly Arg 
            340 


<210>  185
<211>  40
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BESTROPHIN 1 (BEST1), ISOFORM 8 <Accession No.: ALQ33852.1>

<400>  185

Met Phe Glu Lys Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile 
1               5                   10                  15      


Pro Ile Ser Phe Val Leu Gly Asp Glu His Leu Ala Tyr Ser Val Trp 
            20                  25                  30          


Thr Pro Val Cys Leu Arg Leu Asp 
        35                  40  


<210>  186
<211>  764
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR B  <Accession No.: AAA16820.1>

<400>  186

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Gln 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  187
<211>  30
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BETA-AMYLOID, PARTIAL  <Accession No.: AAB29908.1>

<400>  187

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala 
            20                  25                  30  


<210>  188
<211>  82
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BETA-AMYLOID, PARTIAL  <Accession No.: AAB26264.2>

<400>  188

Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys 
1               5                   10                  15      


Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
            20                  25                  30          


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
        35                  40                  45              


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Ile Ile 
    50                  55                  60                  


Thr Leu Val Met Leu Lys Lys Gln Tyr Thr Ser Asn His His Gly Val 
65                  70                  75                  80  


Val Glu 
        


<210>  189
<211>  128
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD59 GLYCOPROTEIN (CD59) <Accession No.: NP_001120697.1>

<400>  189

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  190
<211>  837
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CHANNELRHODOPSIN-1 (CHR1) [VOLVOX CARTERI F. NAGARIENSIS] 
<Accession No.: ABZ90901.1>

<400>  190

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp Asp Thr Val Lys 
    290                 295                 300                 


Gln Ser Thr Ala Lys Tyr Ala Ser Arg Asp Ser Phe Ile Thr Met Arg 
305                 310                 315                 320 


Asn Arg Met Arg Glu Lys Gly Leu Glu Val Arg Ala Ser Leu Asp Ala 
                325                 330                 335     


Gly Gly Gly Asp Ser Gly Met Glu Ala Gly Gly Gly Gly Ala Ala His 
            340                 345                 350         


Ala Gln Pro His Met Ala Lys Pro Gly Thr Glu Leu Gly Lys Thr Met 
        355                 360                 365             


Ser Ala Ser Phe Thr Asn Gly Ala Ala Thr Ser Leu Glu Pro Gly Arg 
    370                 375                 380                 


Val Ile Leu Ala Val Pro Asp Ile Ser Met Val Asp Phe Phe Arg Glu 
385                 390                 395                 400 


Gln Phe Ala Gln Leu Pro Val Pro Tyr Glu Val Val Pro Ala Leu Gly 
                405                 410                 415     


Ala Glu Asn Thr Val Gln Leu Val Gln Gln Ala Ala Met Leu Gly Gly 
            420                 425                 430         


Cys Asp Phe Val Leu Met His Pro Glu Phe Leu Arg Asp Arg Gly Pro 
        435                 440                 445             


Thr Gly Leu Leu Pro Gln Val Lys Met Met Gly Gln Arg Thr Ala Ala 
    450                 455                 460                 


Phe Gly Trp Ser Gln Met Gly Pro Met Arg Asp Leu Ile Glu Ser Ser 
465                 470                 475                 480 


Gly Val Gly Ala Trp Leu Glu Gly Pro Ser Phe Gly Ser Gly Ile Ser 
                485                 490                 495     


Gln Ala Ala Leu Gln Gln Leu Val Val Lys Met Gln Gln Ala Lys Arg 
            500                 505                 510         


Met Ala Ala Met Gly Ser Met Met Gly Gly Gly Met Gly Asn Gly Met 
        515                 520                 525             


Gly Met Gly Met Gly Met Gly Met Gly Met Gly Met Gly Asn Gly Met 
    530                 535                 540                 


Gly Asn Gly Met Gly Met Gly Asn Gly Met Gly Asn Gly Met Gly Met 
545                 550                 555                 560 


Gly Asn Gly Met Gly Asn Gly Met Gly Met Gly Asn Gly Met Gly Met 
                565                 570                 575     


Gly Asn Gly Met Gly Met Gly Asn Gly Met Gly Met Gly Asn Gly Met 
            580                 585                 590         


Gly Asn Gly Met Gly Asn Gly Met Gly Met Gly Asn Gly Met Gly Asn 
        595                 600                 605             


Gly Met Gly Asn Gly Met Gly Asn Gly Met Gly Asn Gly Met Gly Asn 
    610                 615                 620                 


Gly Met Gly Met Gly Asn Gly Met Gly Met Gly Asn Gly Met Gly Asn 
625                 630                 635                 640 


Gly Met Gly Asn Gly Met Gly Asn Gly Met Gly Asn Gly Met Gly Met 
                645                 650                 655     


Met Thr Pro Gly Ala Met Gly Met Gly Met Gly Gly Met Gly Asn Leu 
            660                 665                 670         


Ala Ala Ala Ala Gly Asn Ala Met Tyr Gly Gly Gly Gly Gly Gly Gly 
        675                 680                 685             


Gly Ser Thr Met Gly Ser Gly Asn Ala Ala Met Met Thr Gly Leu Val 
    690                 695                 700                 


Met Gly Gly Gly Asn Gly Val Gly Ala Gly Pro Gly Gly Val Val Ala 
705                 710                 715                 720 


Asn Leu Gly Ser Ser Ala Leu Gln Pro Gln Ser Gln Met Met Gly Gly 
                725                 730                 735     


Gly Asn Val Val Gly Met Ser Ser Pro Gln Leu Gln Leu Gln Gln Ser 
            740                 745                 750         


Ser Ser Met Pro Leu Gly Gly Leu Ala Pro Asn Arg Ile Gly Asn Asn 
        755                 760                 765             


Pro Leu Phe Gly Ala Ala Pro Ser Pro Leu His Ser Gln Pro Gly Ala 
    770                 775                 780                 


Ser Pro Thr Gly Leu Ser Ser Pro Gln Leu Gly Met Gly Ala Met Leu 
785                 790                 795                 800 


Pro Ala Gly Thr Ser Val Gly Ala Gly Gly Gly Ser Val Gly Pro Thr 
                805                 810                 815     


Glu Thr Asp Met Leu Gln Gln Leu Met Thr Glu Ile Asn Arg Leu Lys 
            820                 825                 830         


Asp Glu Leu Gly Glu 
        835         


<210>  191
<211>  747
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CHANNELRHODOPSIN-2 (CHR2) [VOLVOX CARTERI F. NAGARIENSIS 
<Accession No.: ABZ90903.1>

<400>  191

Met Asp His Pro Val Ala Arg Ser Leu Ile Gly Ser Ser Tyr Thr Asn 
1               5                   10                  15      


Leu Asn Asn Gly Ser Ile Val Ile Pro Ser Asp Ala Cys Phe Cys Met 
            20                  25                  30          


Lys Trp Leu Lys Ser Lys Gly Ser Pro Val Ala Leu Lys Met Ala Asn 
        35                  40                  45              


Ala Leu Gln Trp Ala Ala Phe Ala Leu Ser Val Ile Ile Leu Ile Tyr 
    50                  55                  60                  


Tyr Ala Tyr Ala Thr Trp Arg Thr Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Cys Cys Val Glu Leu Thr Lys Val Val Ile Glu Phe Phe His Glu 
                85                  90                  95      


Phe Asp Glu Pro Gly Met Leu Tyr Leu Ala Asn Gly Asn Arg Val Leu 
            100                 105                 110         


Trp Leu Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Asn Lys Arg Thr 
    130                 135                 140                 


Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ala Ala Met Ser Thr Gly Tyr Ile Lys Val Ile Phe Phe Leu Leu Gly 
                165                 170                 175     


Cys Met Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ser Tyr His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg 
        195                 200                 205             


Ala Met Ala Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Pro Glu Gly Phe Gly His Leu Ser Val Tyr Gly Ser 
225                 230                 235                 240 


Thr Ile Gly His Thr Ile Ile Asp Leu Leu Ser Lys Asn Cys Trp Gly 
                245                 250                 255     


Leu Leu Gly His Phe Leu Arg Leu Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Val Gln Lys Ile Arg Val Ala Gly Glu Glu 
        275                 280                 285             


Leu Glu Val Glu Thr Leu Met Thr Glu Glu Ala Pro Asp Thr Val Lys 
    290                 295                 300                 


Lys Ser Thr Ala Gln Tyr Ala Asn Arg Glu Ser Phe Leu Thr Met Arg 
305                 310                 315                 320 


Asp Lys Leu Lys Glu Lys Gly Phe Glu Val Arg Ala Ser Leu Asp Asn 
                325                 330                 335     


Ser Gly Ile Asp Ala Val Ile Asn His Asn Asn Asn Tyr Asn Asn Ala 
            340                 345                 350         


Leu Ala Asn Ala Ala Ala Ala Val Gly Lys Pro Gly Met Glu Leu Ser 
        355                 360                 365             


Lys Leu Asp His Val Ala Ala Asn Ala Ala Gly Met Gly Gly Ile Ala 
    370                 375                 380                 


Asp His Val Ala Thr Thr Ser Gly Ala Ile Ser Pro Gly Arg Val Ile 
385                 390                 395                 400 


Leu Ala Val Pro Asp Ile Ser Met Val Asp Tyr Phe Arg Glu Gln Phe 
                405                 410                 415     


Ala Gln Leu Pro Val Gln Tyr Glu Val Val Pro Ala Leu Gly Ala Asp 
            420                 425                 430         


Asn Ala Val Gln Leu Val Val Gln Ala Ala Gly Leu Gly Gly Cys Asp 
        435                 440                 445             


Phe Val Leu Leu His Pro Glu Phe Leu Arg Asp Lys Ser Ser Thr Ser 
    450                 455                 460                 


Leu Pro Ala Arg Leu Arg Ser Ile Gly Gln Arg Val Ala Ala Phe Gly 
465                 470                 475                 480 


Trp Ser Pro Val Gly Pro Val Arg Asp Leu Ile Glu Ser Ala Gly Leu 
                485                 490                 495     


Asp Gly Trp Leu Glu Gly Pro Ser Phe Gly Leu Gly Ile Ser Leu Pro 
            500                 505                 510         


Asn Leu Ala Ser Leu Val Leu Arg Met Gln His Ala Arg Lys Met Ala 
        515                 520                 525             


Ala Met Leu Gly Gly Met Gly Gly Met Leu Gly Ser Asn Leu Met Ser 
    530                 535                 540                 


Gly Ser Gly Gly Val Gly Leu Met Gly Ala Gly Ser Pro Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Ala Met Gly Val Gly Met Thr Gly Met Gly Met Val Gly Thr 
                565                 570                 575     


Asn Ala Met Gly Arg Gly Ala Val Gly Asn Ser Val Ala Asn Ala Ser 
            580                 585                 590         


Met Gly Gly Gly Ser Ala Gly Met Gly Met Gly Met Met Gly Met Val 
        595                 600                 605             


Gly Ala Gly Val Gly Gly Gln Gln Gln Met Gly Ala Asn Gly Met Gly 
    610                 615                 620                 


Pro Thr Ser Phe Gln Leu Gly Ser Asn Pro Leu Tyr Asn Thr Ala Pro 
625                 630                 635                 640 


Ser Pro Leu Ser Ser Gln Pro Gly Gly Asp Ala Ser Ala Ala Ala Ala 
                645                 650                 655     


Ala Ala Ala Ala Ala Ala Ala Thr Gly Ala Ala Ser Asn Ser Met Asn 
            660                 665                 670         


Ala Met Gln Ala Gly Gly Ser Val Arg Asn Ser Gly Ile Leu Ala Gly 
        675                 680                 685             


Gly Leu Gly Ser Met Met Gly Pro Pro Gly Ala Pro Ala Ala Pro Thr 
    690                 695                 700                 


Ala Ala Ala Thr Ala Ala Pro Ala Val Thr Met Gly Ala Pro Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Ala Ala Ser Glu Ala Glu Met Leu Gln Gln Leu Met Ala 
                725                 730                 735     


Glu Ile Asn Arg Leu Lys Ser Glu Leu Gly Glu 
            740                 745         


<210>  192
<211>  1676
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR C5, ISOFORM 1 <Accession No.: NP_001726.2>

<400>  192

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  193
<211>  1682
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR C5, ISOFORM 2 <Accession No.: NP_001304092.1>

<400>  193

Met Pro Gly Ser Leu Gly Arg Glu Ala Ser Gly Arg Ala Gly Pro Thr 
1               5                   10                  15      


Gly Cys Gly Ala Phe Ala Phe Gly Leu Arg Cys Arg Tyr Val Ile Ser 
            20                  25                  30          


Ala Pro Lys Ile Phe Arg Val Gly Ala Ser Glu Asn Ile Val Ile Gln 
        35                  40                  45              


Val Tyr Gly Tyr Thr Glu Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser 
    50                  55                  60                  


Tyr Pro Asp Lys Lys Phe Ser Tyr Ser Ser Gly His Val His Leu Ser 
65                  70                  75                  80  


Ser Glu Asn Lys Phe Gln Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys 
                85                  90                  95      


Gln Leu Pro Gly Gly Gln Asn Pro Val Ser Tyr Val Tyr Leu Glu Val 
            100                 105                 110         


Val Ser Lys His Phe Ser Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp 
        115                 120                 125             


Asn Gly Phe Leu Phe Ile His Thr Asp Lys Pro Val Tyr Thr Pro Asp 
    130                 135                 140                 


Gln Ser Val Lys Val Arg Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro 
145                 150                 155                 160 


Ala Lys Arg Glu Thr Val Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu 
                165                 170                 175     


Val Asp Met Val Glu Glu Ile Asp His Ile Gly Ile Ile Ser Phe Pro 
            180                 185                 190         


Asp Phe Lys Ile Pro Ser Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys 
        195                 200                 205             


Ala Lys Tyr Lys Glu Asp Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu 
    210                 215                 220                 


Val Lys Glu Tyr Val Leu Pro His Phe Ser Val Ser Ile Glu Pro Glu 
225                 230                 235                 240 


Tyr Asn Phe Ile Gly Tyr Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile 
                245                 250                 255     


Lys Ala Arg Tyr Phe Tyr Asn Lys Val Val Thr Glu Ala Asp Val Tyr 
            260                 265                 270         


Ile Thr Phe Gly Ile Arg Glu Asp Leu Lys Asp Asp Gln Lys Glu Met 
        275                 280                 285             


Met Gln Thr Ala Met Gln Asn Thr Met Leu Ile Asn Gly Ile Ala Gln 
    290                 295                 300                 


Val Thr Phe Asp Ser Glu Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser 
305                 310                 315                 320 


Leu Glu Asp Leu Asn Asn Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile 
                325                 330                 335     


Glu Ser Thr Gly Gly Phe Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys 
            340                 345                 350         


Tyr Val Leu Ser Pro Tyr Lys Leu Asn Leu Val Ala Thr Pro Leu Phe 
        355                 360                 365             


Leu Lys Pro Gly Ile Pro Tyr Pro Ile Lys Val Gln Val Lys Asp Ser 
    370                 375                 380                 


Leu Asp Gln Leu Val Gly Gly Val Pro Val Thr Leu Asn Ala Gln Thr 
385                 390                 395                 400 


Ile Asp Val Asn Gln Glu Thr Ser Asp Leu Asp Pro Ser Lys Ser Val 
                405                 410                 415     


Thr Arg Val Asp Asp Gly Val Ala Ser Phe Val Leu Asn Leu Pro Ser 
            420                 425                 430         


Gly Val Thr Val Leu Glu Phe Asn Val Lys Thr Asp Ala Pro Asp Leu 
        435                 440                 445             


Pro Glu Glu Asn Gln Ala Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser 
    450                 455                 460                 


Ser Leu Ser Gln Ser Tyr Leu Tyr Ile Asp Trp Thr Asp Asn His Lys 
465                 470                 475                 480 


Ala Leu Leu Val Gly Glu His Leu Asn Ile Ile Val Thr Pro Lys Ser 
                485                 490                 495     


Pro Tyr Ile Asp Lys Ile Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys 
            500                 505                 510         


Gly Lys Ile Ile His Phe Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser 
        515                 520                 525             


Tyr Gln Ser Ile Asn Ile Pro Val Thr Gln Asn Met Val Pro Ser Ser 
    530                 535                 540                 


Arg Leu Leu Val Tyr Tyr Ile Val Thr Gly Glu Gln Thr Ala Glu Leu 
545                 550                 555                 560 


Val Ser Asp Ser Val Trp Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln 
                565                 570                 575     


Leu Gln Val His Leu Ser Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln 
            580                 585                 590         


Thr Val Ser Leu Asn Met Ala Thr Gly Met Asp Ser Trp Val Ala Leu 
        595                 600                 605             


Ala Ala Val Asp Ser Ala Val Tyr Gly Val Gln Arg Gly Ala Lys Lys 
    610                 615                 620                 


Pro Leu Glu Arg Val Phe Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys 
625                 630                 635                 640 


Gly Ala Gly Gly Gly Leu Asn Asn Ala Asn Val Phe His Leu Ala Gly 
                645                 650                 655     


Leu Thr Phe Leu Thr Asn Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp 
            660                 665                 670         


Glu Pro Cys Lys Glu Ile Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys 
        675                 680                 685             


Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser Val Val Lys Lys Cys 
    690                 695                 700                 


Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
705                 710                 715                 720 


Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu 
                725                 730                 735     


Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn Ile Ser His Lys Asp 
            740                 745                 750         


Met Gln Leu Gly Arg Leu His Met Lys Thr Leu Leu Pro Val Ser Lys 
        755                 760                 765             


Pro Glu Ile Arg Ser Tyr Phe Pro Glu Ser Trp Leu Trp Glu Val His 
    770                 775                 780                 


Leu Val Pro Arg Arg Lys Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu 
785                 790                 795                 800 


Thr Thr Trp Glu Ile Gln Gly Val Gly Ile Ser Asn Thr Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Thr Val Lys Ala Lys Val Phe Lys Asp Val Phe Leu Glu 
            820                 825                 830         


Met Asn Ile Pro Tyr Ser Val Val Arg Gly Glu Gln Ile Gln Leu Lys 
        835                 840                 845             


Gly Thr Val Tyr Asn Tyr Arg Thr Ser Gly Met Gln Phe Cys Val Lys 
    850                 855                 860                 


Met Ser Ala Val Glu Gly Ile Cys Thr Ser Glu Ser Pro Val Ile Asp 
865                 870                 875                 880 


His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg Gln Lys Val Glu Gly 
                885                 890                 895     


Ser Ser Ser His Leu Val Thr Phe Thr Val Leu Pro Leu Glu Ile Gly 
            900                 905                 910         


Leu His Asn Ile Asn Phe Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile 
        915                 920                 925             


Leu Val Lys Thr Leu Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser 
    930                 935                 940                 


Tyr Ser Gly Val Thr Leu Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser 
945                 950                 955                 960 


Arg Arg Lys Glu Phe Pro Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys 
                965                 970                 975     


Thr Glu Ile Lys Arg Ile Leu Ser Val Lys Gly Leu Leu Val Gly Glu 
            980                 985                 990         


Ile Leu Ser Ala Val Leu Ser Gln  Glu Gly Ile Asn Ile  Leu Thr His 
        995                 1000                 1005             


Leu Pro  Lys Gly Ser Ala Glu  Ala Glu Leu Met Ser  Val Val Pro 
    1010                 1015                 1020             


Val Phe  Tyr Val Phe His Tyr  Leu Glu Thr Gly Asn  His Trp Asn 
    1025                 1030                 1035             


Ile Phe  His Ser Asp Pro Leu  Ile Glu Lys Gln Lys  Leu Lys Lys 
    1040                 1045                 1050             


Lys Leu  Lys Glu Gly Met Leu  Ser Ile Met Ser Tyr  Arg Asn Ala 
    1055                 1060                 1065             


Asp Tyr  Ser Tyr Ser Val Trp  Lys Gly Gly Ser Ala  Ser Thr Trp 
    1070                 1075                 1080             


Leu Thr  Ala Phe Ala Leu Arg  Val Leu Gly Gln Val  Asn Lys Tyr 
    1085                 1090                 1095             


Val Glu  Gln Asn Gln Asn Ser  Ile Cys Asn Ser Leu  Leu Trp Leu 
    1100                 1105                 1110             


Val Glu  Asn Tyr Gln Leu Asp  Asn Gly Ser Phe Lys  Glu Asn Ser 
    1115                 1120                 1125             


Gln Tyr  Gln Pro Ile Lys Leu  Gln Gly Thr Leu Pro  Val Glu Ala 
    1130                 1135                 1140             


Arg Glu  Asn Ser Leu Tyr Leu  Thr Ala Phe Thr Val  Ile Gly Ile 
    1145                 1150                 1155             


Arg Lys  Ala Phe Asp Ile Cys  Pro Leu Val Lys Ile  Asp Thr Ala 
    1160                 1165                 1170             


Leu Ile  Lys Ala Asp Asn Phe  Leu Leu Glu Asn Thr  Leu Pro Ala 
    1175                 1180                 1185             


Gln Ser  Thr Phe Thr Leu Ala  Ile Ser Ala Tyr Ala  Leu Ser Leu 
    1190                 1195                 1200             


Gly Asp  Lys Thr His Pro Gln  Phe Arg Ser Ile Val  Ser Ala Leu 
    1205                 1210                 1215             


Lys Arg  Glu Ala Leu Val Lys  Gly Asn Pro Pro Ile  Tyr Arg Phe 
    1220                 1225                 1230             


Trp Lys  Asp Asn Leu Gln His  Lys Asp Ser Ser Val  Pro Asn Thr 
    1235                 1240                 1245             


Gly Thr  Ala Arg Met Val Glu  Thr Thr Ala Tyr Ala  Leu Leu Thr 
    1250                 1255                 1260             


Ser Leu  Asn Leu Lys Asp Ile  Asn Tyr Val Asn Pro  Val Ile Lys 
    1265                 1270                 1275             


Trp Leu  Ser Glu Glu Gln Arg  Tyr Gly Gly Gly Phe  Tyr Ser Thr 
    1280                 1285                 1290             


Gln Asp  Thr Ile Asn Ala Ile  Glu Gly Leu Thr Glu  Tyr Ser Leu 
    1295                 1300                 1305             


Leu Val  Lys Gln Leu Arg Leu  Ser Met Asp Ile Asp  Val Ser Tyr 
    1310                 1315                 1320             


Lys His  Lys Gly Ala Leu His  Asn Tyr Lys Met Thr  Asp Lys Asn 
    1325                 1330                 1335             


Phe Leu  Gly Arg Pro Val Glu  Val Leu Leu Asn Asp  Asp Leu Ile 
    1340                 1345                 1350             


Val Ser  Thr Gly Phe Gly Ser  Gly Leu Ala Thr Val  His Val Thr 
    1355                 1360                 1365             


Thr Val  Val His Lys Thr Ser  Thr Ser Glu Glu Val  Cys Ser Phe 
    1370                 1375                 1380             


Tyr Leu  Lys Ile Asp Thr Gln  Asp Ile Glu Ala Ser  His Tyr Arg 
    1385                 1390                 1395             


Gly Tyr  Gly Asn Ser Asp Tyr  Lys Arg Ile Val Ala  Cys Ala Ser 
    1400                 1405                 1410             


Tyr Lys  Pro Ser Arg Glu Glu  Ser Ser Ser Gly Ser  Ser His Ala 
    1415                 1420                 1425             


Val Met  Asp Ile Ser Leu Pro  Thr Gly Ile Ser Ala  Asn Glu Glu 
    1430                 1435                 1440             


Asp Leu  Lys Ala Leu Val Glu  Gly Val Asp Gln Leu  Phe Thr Asp 
    1445                 1450                 1455             


Tyr Gln  Ile Lys Asp Gly His  Val Ile Leu Gln Leu  Asn Ser Ile 
    1460                 1465                 1470             


Pro Ser  Ser Asp Phe Leu Cys  Val Arg Phe Arg Ile  Phe Glu Leu 
    1475                 1480                 1485             


Phe Glu  Val Gly Phe Leu Ser  Pro Ala Thr Phe Thr  Val Tyr Glu 
    1490                 1495                 1500             


Tyr His  Arg Pro Asp Lys Gln  Cys Thr Met Phe Tyr  Ser Thr Ser 
    1505                 1510                 1515             


Asn Ile  Lys Ile Gln Lys Val  Cys Glu Gly Ala Ala  Cys Lys Cys 
    1520                 1525                 1530             


Val Glu  Ala Asp Cys Gly Gln  Met Gln Glu Glu Leu  Asp Leu Thr 
    1535                 1540                 1545             


Ile Ser  Ala Glu Thr Arg Lys  Gln Thr Ala Cys Lys  Pro Glu Ile 
    1550                 1555                 1560             


Ala Tyr  Ala Tyr Lys Val Ser  Ile Thr Ser Ile Thr  Val Glu Asn 
    1565                 1570                 1575             


Val Phe  Val Lys Tyr Lys Ala  Thr Leu Leu Asp Ile  Tyr Lys Thr 
    1580                 1585                 1590             


Gly Glu  Ala Val Ala Glu Lys  Asp Ser Glu Ile Thr  Phe Ile Lys 
    1595                 1600                 1605             


Lys Val  Thr Cys Thr Asn Ala  Glu Leu Val Lys Gly  Arg Gln Tyr 
    1610                 1615                 1620             


Leu Ile  Met Gly Lys Glu Ala  Leu Gln Ile Lys Tyr  Asn Phe Ser 
    1625                 1630                 1635             


Phe Arg  Tyr Ile Tyr Pro Leu  Asp Ser Leu Thr Trp  Ile Glu Tyr 
    1640                 1645                 1650             


Trp Pro  Arg Asp Thr Thr Cys  Ser Ser Cys Gln Ala  Phe Leu Ala 
    1655                 1660                 1665             


Asn Leu  Asp Glu Phe Ala Glu  Asp Ile Phe Leu Asn  Gly Cys 
    1670                 1675                 1680         


<210>  194
<211>  902
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR C5, ISOFORM 2 <Accession No.: NP_001304093.1>

<400>  194

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Ser Leu Ala Leu Ser Pro Arg Leu Glu Cys 
    850                 855                 860                 


Asn Gly Lys Ile Ser Gly His Cys Lys Leu Arg Leu Pro Gly Ser Ser 
865                 870                 875                 880 


Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Gly Thr His 
                885                 890                 895     


His His Ala Gln Pro Thr 
            900         


<210>  195
<211>  1676
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR C5A <Accession No.: 3PVM_A>

<400>  195

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  196
<211>  253
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR D, ISOFORM 1 <Accession No.: NP_001919.2>

<400>  196

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  197
<211>  260
<212>  PRT
<213>  Homo sapiens

<220>
<223>  COMPLEMENT FACTOR D, ISOFORM 2 <Accession No.: NP_001304264.1>

<400>  197

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Gly Glu Glu Ala Trp Ala Trp Ala Ala Pro Pro Arg Gly Arg 
            20                  25                  30          


Ile Leu Gly Gly Arg Glu Ala Glu Ala His Ala Arg Pro Tyr Met Ala 
        35                  40                  45              


Ser Val Gln Leu Asn Gly Ala His Leu Cys Gly Gly Val Leu Val Ala 
    50                  55                  60                  


Glu Gln Trp Val Leu Ser Ala Ala His Cys Leu Glu Asp Ala Ala Asp 
65                  70                  75                  80  


Gly Lys Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Gln Pro Glu 
                85                  90                  95      


Pro Ser Lys Arg Leu Tyr Asp Val Leu Arg Ala Val Pro His Pro Asp 
            100                 105                 110         


Ser Gln Pro Asp Thr Ile Asp His Asp Leu Leu Leu Leu Gln Leu Ser 
        115                 120                 125             


Glu Lys Ala Thr Leu Gly Pro Ala Val Arg Pro Leu Pro Trp Gln Arg 
    130                 135                 140                 


Val Asp Arg Asp Val Ala Pro Gly Thr Leu Cys Asp Val Ala Gly Trp 
145                 150                 155                 160 


Gly Ile Val Asn His Ala Gly Arg Arg Pro Asp Ser Leu Gln His Val 
                165                 170                 175     


Leu Leu Pro Val Leu Asp Arg Ala Thr Cys Asn Arg Arg Thr His His 
            180                 185                 190         


Asp Gly Ala Ile Thr Glu Arg Leu Met Cys Ala Glu Ser Asn Arg Arg 
        195                 200                 205             


Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly Val 
    210                 215                 220                 


Leu Glu Gly Val Val Thr Ser Gly Ser Arg Val Cys Gly Asn Arg Lys 
225                 230                 235                 240 


Lys Pro Gly Ile Tyr Thr Arg Val Ala Ser Tyr Ala Ala Trp Ile Asp 
                245                 250                 255     


Ser Val Leu Ala 
            260 


<210>  198
<211>  504
<212>  PRT
<213>  Homo sapiens

<220>
<223>  DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER C3 (DNAJC3), 
ALSO KNOWN AS P58IPK <Accession No.: NP_006251.1>

<400>  198

Met Val Ala Pro Gly Ser Val Thr Ser Arg Leu Gly Ser Val Phe Pro 
1               5                   10                  15      


Phe Leu Leu Val Leu Val Asp Leu Gln Tyr Glu Gly Ala Glu Cys Gly 
            20                  25                  30          


Val Asn Ala Asp Val Glu Lys His Leu Glu Leu Gly Lys Lys Leu Leu 
        35                  40                  45              


Ala Ala Gly Gln Leu Ala Asp Ala Leu Ser Gln Phe His Ala Ala Val 
    50                  55                  60                  


Asp Gly Asp Pro Asp Asn Tyr Ile Ala Tyr Tyr Arg Arg Ala Thr Val 
65                  70                  75                  80  


Phe Leu Ala Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys 
                85                  90                  95      


Val Ile Gln Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly 
            100                 105                 110         


His Leu Leu Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe 
        115                 120                 125             


Lys Lys Val Leu Lys Ser Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala 
    130                 135                 140                 


Gln Ser Gln Leu Ile Lys Ser Asp Glu Met Gln Arg Leu Arg Ser Gln 
145                 150                 155                 160 


Ala Leu Asn Ala Phe Gly Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe 
                165                 170                 175     


Leu Asp Lys Ile Leu Glu Val Cys Val Trp Asp Ala Glu Leu Arg Glu 
            180                 185                 190         


Leu Arg Ala Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile 
        195                 200                 205             


Ser Asp Leu Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala 
    210                 215                 220                 


Phe Tyr Lys Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu 
225                 230                 235                 240 


Ser Leu Ser Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys 
                245                 250                 255     


Arg Cys Phe Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile 
            260                 265                 270         


Glu Ser Ala Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr 
        275                 280                 285             


Ser Lys Tyr Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr 
    290                 295                 300                 


Thr Val Arg Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu 
305                 310                 315                 320 


Lys Pro Val Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu 
                325                 330                 335     


Pro Asp Asn Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile 
            340                 345                 350         


Glu Glu Met Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu 
        355                 360                 365             


His Asn Glu Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln 
    370                 375                 380                 


Arg Leu Leu Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly 
385                 390                 395                 400 


Val Lys Arg Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys 
                405                 410                 415     


Leu Ala Leu Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys 
            420                 425                 430         


Lys Lys Ala Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val 
        435                 440                 445             


Leu Ser Asp Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro 
    450                 455                 460                 


Leu Asp Ala Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg 
465                 470                 475                 480 


Ser Trp Asn Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro 
                485                 490                 495     


Phe Arg Phe Lys Phe His Phe Asn 
            500                 


<210>  199
<211>  533
<212>  PRT
<213>  Homo sapiens

<220>
<223>  DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER C3 (DNAJC3), 
ALSO KNOWN AS P58IPK, ISOFORM X1 <Accession No.: XP_011519406.1>

<400>  199

Met Val Ala Pro Gly Ser Val Thr Ser Arg Leu Gly Ser Val Phe Pro 
1               5                   10                  15      


Phe Leu Leu Val Leu Val Asp Leu Gln Tyr Glu Gly Ala Glu Cys Gly 
            20                  25                  30          


Val Asn Ala Asp Val Glu Lys His Leu Glu Leu Gly Lys Lys Leu Leu 
        35                  40                  45              


Ala Ala Gly Gln Leu Ala Asp Ala Leu Ser Gln Phe His Ala Ala Val 
    50                  55                  60                  


Asp Gly Asp Pro Asp Asn Tyr Ile Ala Tyr Tyr Arg Arg Ala Thr Val 
65                  70                  75                  80  


Phe Leu Ala Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys 
                85                  90                  95      


Val Ile Gln Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly 
            100                 105                 110         


His Leu Leu Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe 
        115                 120                 125             


Lys Lys Val Val Phe Pro Val Pro Ser Leu Leu Gly Leu Gln Arg Ser 
    130                 135                 140                 


Leu Leu Asp Asp Leu Tyr Leu Leu Phe Trp Phe Phe Leu Met Lys Lys 
145                 150                 155                 160 


Leu Lys Ser Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala Gln Ser Gln 
                165                 170                 175     


Leu Ile Lys Ser Asp Glu Met Gln Arg Leu Arg Ser Gln Ala Leu Asn 
            180                 185                 190         


Ala Phe Gly Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe Leu Asp Lys 
        195                 200                 205             


Ile Leu Glu Val Cys Val Trp Asp Ala Glu Leu Arg Glu Leu Arg Ala 
    210                 215                 220                 


Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile Ser Asp Leu 
225                 230                 235                 240 


Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala Phe Tyr Lys 
                245                 250                 255     


Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu Ser Leu Ser 
            260                 265                 270         


Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys Arg Cys Phe 
        275                 280                 285             


Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile Glu Ser Ala 
    290                 295                 300                 


Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr Ser Lys Tyr 
305                 310                 315                 320 


Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr Thr Val Arg 
                325                 330                 335     


Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu Lys Pro Val 
            340                 345                 350         


Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu Pro Asp Asn 
        355                 360                 365             


Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile Glu Glu Met 
    370                 375                 380                 


Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu His Asn Glu 
385                 390                 395                 400 


Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln Arg Leu Leu 
                405                 410                 415     


Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly Val Lys Arg 
            420                 425                 430         


Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys Leu Ala Leu 
        435                 440                 445             


Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys Lys Lys Ala 
    450                 455                 460                 


Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val Leu Ser Asp 
465                 470                 475                 480 


Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro Leu Asp Ala 
                485                 490                 495     


Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg Ser Trp Asn 
            500                 505                 510         


Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro Phe Arg Phe 
        515                 520                 525             


Lys Phe His Phe Asn 
    530             


<210>  200
<211>  450
<212>  PRT
<213>  Homo sapiens

<220>
<223>  DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER C3 (DNAJC3), 
ALSO KNOWN AS P58IPK, ISOFORM X2 <Accession No.: XP_011519407.1>

<400>  200

Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys Val Ile Gln 
1               5                   10                  15      


Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly His Leu Leu 
            20                  25                  30          


Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe Lys Lys Val 
        35                  40                  45              


Val Phe Pro Val Pro Ser Leu Leu Gly Leu Gln Arg Ser Leu Leu Asp 
    50                  55                  60                  


Asp Leu Tyr Leu Leu Phe Trp Phe Phe Leu Met Lys Lys Leu Lys Ser 
65                  70                  75                  80  


Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala Gln Ser Gln Leu Ile Lys 
                85                  90                  95      


Ser Asp Glu Met Gln Arg Leu Arg Ser Gln Ala Leu Asn Ala Phe Gly 
            100                 105                 110         


Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe Leu Asp Lys Ile Leu Glu 
        115                 120                 125             


Val Cys Val Trp Asp Ala Glu Leu Arg Glu Leu Arg Ala Glu Cys Phe 
    130                 135                 140                 


Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile Ser Asp Leu Lys Ala Ala 
145                 150                 155                 160 


Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala Phe Tyr Lys Ile Ser Thr 
                165                 170                 175     


Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu Ser Leu Ser Glu Val Arg 
            180                 185                 190         


Glu Cys Leu Lys Leu Asp Gln Asp His Lys Arg Cys Phe Ala His Tyr 
        195                 200                 205             


Lys Gln Val Lys Lys Leu Asn Lys Leu Ile Glu Ser Ala Glu Glu Leu 
    210                 215                 220                 


Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr Ser Lys Tyr Glu Ser Val 
225                 230                 235                 240 


Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr Thr Val Arg Ser Lys Glu 
                245                 250                 255     


Arg Ile Cys His Cys Phe Ser Lys Asp Glu Lys Pro Val Glu Ala Ile 
            260                 265                 270         


Arg Val Cys Ser Glu Val Leu Gln Met Glu Pro Asp Asn Val Asn Ala 
        275                 280                 285             


Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile Glu Glu Met Tyr Asp Glu 
    290                 295                 300                 


Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu His Asn Glu Asn Asp Gln 
305                 310                 315                 320 


Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln Arg Leu Leu Lys Gln Ser 
                325                 330                 335     


Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly Val Lys Arg Asn Ala Lys 
            340                 345                 350         


Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys Leu Ala Leu Gln Trp His 
        355                 360                 365             


Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys Lys Lys Ala Glu Lys Lys 
    370                 375                 380                 


Phe Ile Asp Ile Ala Ala Ala Lys Glu Val Leu Ser Asp Pro Glu Met 
385                 390                 395                 400 


Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro Leu Asp Ala Glu Ser Gln 
                405                 410                 415     


Gln Gly Gly Gly Gly Asn Pro Phe His Arg Ser Trp Asn Ser Trp Gln 
            420                 425                 430         


Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro Phe Arg Phe Lys Phe His 
        435                 440                 445             


Phe Asn 
    450 


<210>  201
<211>  421
<212>  PRT
<213>  Homo sapiens

<220>
<223>  DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER C3 (DNAJC3), 
ALSO KNOWN AS P58IPK, ISOFORM X3 <Accession No.: XP_016876163.1>

<400>  201

Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys Val Ile Gln 
1               5                   10                  15      


Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly His Leu Leu 
            20                  25                  30          


Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe Lys Lys Val 
        35                  40                  45              


Leu Lys Ser Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala Gln Ser Gln 
    50                  55                  60                  


Leu Ile Lys Ser Asp Glu Met Gln Arg Leu Arg Ser Gln Ala Leu Asn 
65                  70                  75                  80  


Ala Phe Gly Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe Leu Asp Lys 
                85                  90                  95      


Ile Leu Glu Val Cys Val Trp Asp Ala Glu Leu Arg Glu Leu Arg Ala 
            100                 105                 110         


Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile Ser Asp Leu 
        115                 120                 125             


Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala Phe Tyr Lys 
    130                 135                 140                 


Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu Ser Leu Ser 
145                 150                 155                 160 


Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys Arg Cys Phe 
                165                 170                 175     


Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile Glu Ser Ala 
            180                 185                 190         


Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr Ser Lys Tyr 
        195                 200                 205             


Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr Thr Val Arg 
    210                 215                 220                 


Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu Lys Pro Val 
225                 230                 235                 240 


Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu Pro Asp Asn 
                245                 250                 255     


Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile Glu Glu Met 
            260                 265                 270         


Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu His Asn Glu 
        275                 280                 285             


Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln Arg Leu Leu 
    290                 295                 300                 


Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly Val Lys Arg 
305                 310                 315                 320 


Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys Leu Ala Leu 
                325                 330                 335     


Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys Lys Lys Ala 
            340                 345                 350         


Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val Leu Ser Asp 
        355                 360                 365             


Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro Leu Asp Ala 
    370                 375                 380                 


Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg Ser Trp Asn 
385                 390                 395                 400 


Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro Phe Arg Phe 
                405                 410                 415     


Lys Phe His Phe Asn 
            420     


<210>  202
<211>  383
<212>  PRT
<213>  Homo sapiens

<220>
<223>  DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER C3 (DNAJC3), 
ALSO KNOWN AS P58IPK, ISOFORM X4 <Accession No.: XP_016876164.1>

<400>  202

Met Cys Phe Leu His Phe Phe Lys Lys Val Leu Lys Ser Asn Pro Ser 
1               5                   10                  15      


Glu Asn Glu Glu Lys Glu Ala Gln Ser Gln Leu Ile Lys Ser Asp Glu 
            20                  25                  30          


Met Gln Arg Leu Arg Ser Gln Ala Leu Asn Ala Phe Gly Ser Gly Asp 
        35                  40                  45              


Tyr Thr Ala Ala Ile Ala Phe Leu Asp Lys Ile Leu Glu Val Cys Val 
    50                  55                  60                  


Trp Asp Ala Glu Leu Arg Glu Leu Arg Ala Glu Cys Phe Ile Lys Glu 
65                  70                  75                  80  


Gly Glu Pro Arg Lys Ala Ile Ser Asp Leu Lys Ala Ala Ser Lys Leu 
                85                  90                  95      


Lys Asn Asp Asn Thr Glu Ala Phe Tyr Lys Ile Ser Thr Leu Tyr Tyr 
            100                 105                 110         


Gln Leu Gly Asp His Glu Leu Ser Leu Ser Glu Val Arg Glu Cys Leu 
        115                 120                 125             


Lys Leu Asp Gln Asp His Lys Arg Cys Phe Ala His Tyr Lys Gln Val 
    130                 135                 140                 


Lys Lys Leu Asn Lys Leu Ile Glu Ser Ala Glu Glu Leu Ile Arg Asp 
145                 150                 155                 160 


Gly Arg Tyr Thr Asp Ala Thr Ser Lys Tyr Glu Ser Val Met Lys Thr 
                165                 170                 175     


Glu Pro Ser Ile Ala Glu Tyr Thr Val Arg Ser Lys Glu Arg Ile Cys 
            180                 185                 190         


His Cys Phe Ser Lys Asp Glu Lys Pro Val Glu Ala Ile Arg Val Cys 
        195                 200                 205             


Ser Glu Val Leu Gln Met Glu Pro Asp Asn Val Asn Ala Leu Lys Asp 
    210                 215                 220                 


Arg Ala Glu Ala Tyr Leu Ile Glu Glu Met Tyr Asp Glu Ala Ile Gln 
225                 230                 235                 240 


Asp Tyr Glu Thr Ala Gln Glu His Asn Glu Asn Asp Gln Gln Ile Arg 
                245                 250                 255     


Glu Gly Leu Glu Lys Ala Gln Arg Leu Leu Lys Gln Ser Gln Lys Arg 
            260                 265                 270         


Asp Tyr Tyr Lys Ile Leu Gly Val Lys Arg Asn Ala Lys Lys Gln Glu 
        275                 280                 285             


Ile Ile Lys Ala Tyr Arg Lys Leu Ala Leu Gln Trp His Pro Asp Asn 
    290                 295                 300                 


Phe Gln Asn Glu Glu Glu Lys Lys Lys Ala Glu Lys Lys Phe Ile Asp 
305                 310                 315                 320 


Ile Ala Ala Ala Lys Glu Val Leu Ser Asp Pro Glu Met Arg Lys Lys 
                325                 330                 335     


Phe Asp Asp Gly Glu Asp Pro Leu Asp Ala Glu Ser Gln Gln Gly Gly 
            340                 345                 350         


Gly Gly Asn Pro Phe His Arg Ser Trp Asn Ser Trp Gln Gly Phe Asn 
        355                 360                 365             


Pro Phe Ser Ser Gly Gly Pro Phe Arg Phe Lys Phe His Phe Asn 
    370                 375                 380             


<210>  203
<211>  413
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BETA-2 ADRENOCEPTOR  <Accession No.: NP_000015.1>

<400>  203

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210>  204
<211>  252
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CASPASE-2 (CASP2) <Accession No.: AAX36439.1>

<400>  204

Pro Lys Arg Gly Pro Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg 
1               5                   10                  15      


Glu Thr Lys Gln Gly His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser 
            20                  25                  30          


Gly Leu Gln His Val Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser 
        35                  40                  45              


Leu Pro Phe Pro Val Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg 
    50                  55                  60                  


Leu Ser Thr Asp Thr Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro 
65                  70                  75                  80  


Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His 
                85                  90                  95      


Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu 
            100                 105                 110         


Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg 
        115                 120                 125             


Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu 
    130                 135                 140                 


Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met 
145                 150                 155                 160 


Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr 
                165                 170                 175     


Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile 
            180                 185                 190         


Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu 
        195                 200                 205             


Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe 
    210                 215                 220                 


Phe Ile Gln Ala Cys Arg Gly Gly Ala Ile Gly Ser Leu Gly His Leu 
225                 230                 235                 240 


Leu Leu Phe Thr Ala Ala Thr Ala Ser Leu Ala Leu 
                245                 250         


<210>  205
<211>  1242
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INSULIN RECEPTOR SUBSTRATE 1 (IRS1) <Accession No.: 
NP_005535.1>

<400>  205

Met Ala Ser Pro Pro Glu Ser Asp Gly Phe Ser Asp Val Arg Lys Val 
1               5                   10                  15      


Gly Tyr Leu Arg Lys Pro Lys Ser Met His Lys Arg Phe Phe Val Leu 
            20                  25                  30          


Arg Ala Ala Ser Glu Ala Gly Gly Pro Ala Arg Leu Glu Tyr Tyr Glu 
        35                  40                  45              


Asn Glu Lys Lys Trp Arg His Lys Ser Ser Ala Pro Lys Arg Ser Ile 
    50                  55                  60                  


Pro Leu Glu Ser Cys Phe Asn Ile Asn Lys Arg Ala Asp Ser Lys Asn 
65                  70                  75                  80  


Lys His Leu Val Ala Leu Tyr Thr Arg Asp Glu His Phe Ala Ile Ala 
                85                  90                  95      


Ala Asp Ser Glu Ala Glu Gln Asp Ser Trp Tyr Gln Ala Leu Leu Gln 
            100                 105                 110         


Leu His Asn Arg Ala Lys Gly His His Asp Gly Ala Ala Ala Leu Gly 
        115                 120                 125             


Ala Gly Gly Gly Gly Gly Ser Cys Ser Gly Ser Ser Gly Leu Gly Glu 
    130                 135                 140                 


Ala Gly Glu Asp Leu Ser Tyr Gly Asp Val Pro Pro Gly Pro Ala Phe 
145                 150                 155                 160 


Lys Glu Val Trp Gln Val Ile Leu Lys Pro Lys Gly Leu Gly Gln Thr 
                165                 170                 175     


Lys Asn Leu Ile Gly Ile Tyr Arg Leu Cys Leu Thr Ser Lys Thr Ile 
            180                 185                 190         


Ser Phe Val Lys Leu Asn Ser Glu Ala Ala Ala Val Val Leu Gln Leu 
        195                 200                 205             


Met Asn Ile Arg Arg Cys Gly His Ser Glu Asn Phe Phe Phe Ile Glu 
    210                 215                 220                 


Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Phe Trp Met Gln Val 
225                 230                 235                 240 


Asp Asp Ser Val Val Ala Gln Asn Met His Glu Thr Ile Leu Glu Ala 
                245                 250                 255     


Met Arg Ala Met Ser Asp Glu Phe Arg Pro Arg Ser Lys Ser Gln Ser 
            260                 265                 270         


Ser Ser Asn Cys Ser Asn Pro Ile Ser Val Pro Leu Arg Arg His His 
        275                 280                 285             


Leu Asn Asn Pro Pro Pro Ser Gln Val Gly Leu Thr Arg Arg Ser Arg 
    290                 295                 300                 


Thr Glu Ser Ile Thr Ala Thr Ser Pro Ala Ser Met Val Gly Gly Lys 
305                 310                 315                 320 


Pro Gly Ser Phe Arg Val Arg Ala Ser Ser Asp Gly Glu Gly Thr Met 
                325                 330                 335     


Ser Arg Pro Ala Ser Val Asp Gly Ser Pro Val Ser Pro Ser Thr Asn 
            340                 345                 350         


Arg Thr His Ala His Arg His Arg Gly Ser Ala Arg Leu His Pro Pro 
        355                 360                 365             


Leu Asn His Ser Arg Ser Ile Pro Met Pro Ala Ser Arg Cys Ser Pro 
    370                 375                 380                 


Ser Ala Thr Ser Pro Val Ser Leu Ser Ser Ser Ser Thr Ser Gly His 
385                 390                 395                 400 


Gly Ser Thr Ser Asp Cys Leu Phe Pro Arg Arg Ser Ser Ala Ser Val 
                405                 410                 415     


Ser Gly Ser Pro Ser Asp Gly Gly Phe Ile Ser Ser Asp Glu Tyr Gly 
            420                 425                 430         


Ser Ser Pro Cys Asp Phe Arg Ser Ser Phe Arg Ser Val Thr Pro Asp 
        435                 440                 445             


Ser Leu Gly His Thr Pro Pro Ala Arg Gly Glu Glu Glu Leu Ser Asn 
    450                 455                 460                 


Tyr Ile Cys Met Gly Gly Lys Gly Pro Ser Thr Leu Thr Ala Pro Asn 
465                 470                 475                 480 


Gly His Tyr Ile Leu Ser Arg Gly Gly Asn Gly His Arg Cys Thr Pro 
                485                 490                 495     


Gly Thr Gly Leu Gly Thr Ser Pro Ala Leu Ala Gly Asp Glu Ala Ala 
            500                 505                 510         


Ser Ala Ala Asp Leu Asp Asn Arg Phe Arg Lys Arg Thr His Ser Ala 
        515                 520                 525             


Gly Thr Ser Pro Thr Ile Thr His Gln Lys Thr Pro Ser Gln Ser Ser 
    530                 535                 540                 


Val Ala Ser Ile Glu Glu Tyr Thr Glu Met Met Pro Ala Tyr Pro Pro 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Arg Leu Pro Gly His Arg His Ser Ala Phe 
                565                 570                 575     


Val Pro Thr Arg Ser Tyr Pro Glu Glu Gly Leu Glu Met His Pro Leu 
            580                 585                 590         


Glu Arg Arg Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr 
        595                 600                 605             


Asp Asp Gly Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser 
    610                 615                 620                 


Gly Arg Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys Ser Val 
625                 630                 635                 640 


Ser Ala Pro Gln Gln Ile Ile Asn Pro Ile Arg Arg His Pro Gln Arg 
                645                 650                 655     


Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser 
            660                 665                 670         


Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala 
        675                 680                 685             


Val Pro Ser Gly Thr Ser Tyr Gly Lys Leu Trp Thr Asn Gly Val Gly 
    690                 695                 700                 


Gly His His Ser His Val Leu Pro His Pro Lys Pro Pro Val Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Lys Leu Leu Pro Cys Thr Gly Asp Tyr Met Asn Met Ser 
                725                 730                 735     


Pro Val Gly Asp Ser Asn Thr Ser Ser Pro Ser Asp Cys Tyr Tyr Gly 
            740                 745                 750         


Pro Glu Asp Pro Gln His Lys Pro Val Leu Ser Tyr Tyr Ser Leu Pro 
        755                 760                 765             


Arg Ser Phe Lys His Thr Gln Arg Pro Gly Glu Pro Glu Glu Gly Ala 
    770                 775                 780                 


Arg His Gln His Leu Arg Leu Ser Thr Ser Ser Gly Arg Leu Leu Tyr 
785                 790                 795                 800 


Ala Ala Thr Ala Asp Asp Ser Ser Ser Ser Thr Ser Ser Asp Ser Leu 
                805                 810                 815     


Gly Gly Gly Tyr Cys Gly Ala Arg Leu Glu Pro Ser Leu Pro His Pro 
            820                 825                 830         


His His Gln Val Leu Gln Pro His Leu Pro Arg Lys Val Asp Thr Ala 
        835                 840                 845             


Ala Gln Thr Asn Ser Arg Leu Ala Arg Pro Thr Arg Leu Ser Leu Gly 
    850                 855                 860                 


Asp Pro Lys Ala Ser Thr Leu Pro Arg Ala Arg Glu Gln Gln Gln Gln 
865                 870                 875                 880 


Gln Gln Pro Leu Leu His Pro Pro Glu Pro Lys Ser Pro Gly Glu Tyr 
                885                 890                 895     


Val Asn Ile Glu Phe Gly Ser Asp Gln Ser Gly Tyr Leu Ser Gly Pro 
            900                 905                 910         


Val Ala Phe His Ser Ser Pro Ser Val Arg Cys Pro Ser Gln Leu Gln 
        915                 920                 925             


Pro Ala Pro Arg Glu Glu Glu Thr Gly Thr Glu Glu Tyr Met Lys Met 
    930                 935                 940                 


Asp Leu Gly Pro Gly Arg Arg Ala Ala Trp Gln Glu Ser Thr Gly Val 
945                 950                 955                 960 


Glu Met Gly Arg Leu Gly Pro Ala Pro Pro Gly Ala Ala Ser Ile Cys 
                965                 970                 975     


Arg Pro Thr Arg Ala Val Pro Ser Ser Arg Gly Asp Tyr Met Thr Met 
            980                 985                 990         


Gln Met Ser Cys Pro Arg Gln Ser  Tyr Val Asp Thr Ser  Pro Ala Ala 
        995                 1000                 1005             


Pro Val  Ser Tyr Ala Asp Met  Arg Thr Gly Ile Ala  Ala Glu Glu 
    1010                 1015                 1020             


Val Ser  Leu Pro Arg Ala Thr  Met Ala Ala Ala Ser  Ser Ser Ser 
    1025                 1030                 1035             


Ala Ala  Ser Ala Ser Pro Thr  Gly Pro Gln Gly Ala  Ala Glu Leu 
    1040                 1045                 1050             


Ala Ala  His Ser Ser Leu Leu  Gly Gly Pro Gln Gly  Pro Gly Gly 
    1055                 1060                 1065             


Met Ser  Ala Phe Thr Arg Val  Asn Leu Ser Pro Asn  Arg Asn Gln 
    1070                 1075                 1080             


Ser Ala  Lys Val Ile Arg Ala  Asp Pro Gln Gly Cys  Arg Arg Arg 
    1085                 1090                 1095             


His Ser  Ser Glu Thr Phe Ser  Ser Thr Pro Ser Ala  Thr Arg Val 
    1100                 1105                 1110             


Gly Asn  Thr Val Pro Phe Gly  Ala Gly Ala Ala Val  Gly Gly Gly 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Ser Ser  Glu Asp Val Lys Arg  His Ser Ser 
    1130                 1135                 1140             


Ala Ser  Phe Glu Asn Val Trp  Leu Arg Pro Gly Glu  Leu Gly Gly 
    1145                 1150                 1155             


Ala Pro  Lys Glu Pro Ala Lys  Leu Cys Gly Ala Ala  Gly Gly Leu 
    1160                 1165                 1170             


Glu Asn  Gly Leu Asn Tyr Ile  Asp Leu Asp Leu Val  Lys Asp Phe 
    1175                 1180                 1185             


Lys Gln  Cys Pro Gln Glu Cys  Thr Pro Glu Pro Gln  Pro Pro Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro His Gln Pro  Leu Gly Ser Gly Glu  Ser Ser Ser 
    1205                 1210                 1215             


Thr Arg  Arg Ser Ser Glu Asp  Leu Ser Ala Tyr Ala  Ser Ile Ser 
    1220                 1225                 1230             


Phe Gln  Lys Gln Pro Glu Asp  Arg Gln 
    1235                 1240         


<210>  206
<211>  232
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HIF-1 RESPONSIVE PROTEIN RTP801 (RTP801) <Accession 
No.: Q9NX09.1>

<400>  206

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  207
<211>  414
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRANSFORMING GROWTH FACTOR BETA 2 (TGFB2) <Accession 
No.: AAH99635.1>

<400>  207

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  208
<211>  442
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRANSFORMING GROWTH FACTOR BETA 2 (TGFB2), ISOFORM CRA_A 
<Accession No.: EAW93326.1>

<400>  208

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210>  209
<211>  414
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRANSFORMING GROWTH FACTOR BETA 2 (TGFB2), ISOFORM CRA_B 
<Accession No.: EAW93327.1>

<400>  209

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  210
<211>  247
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) <Accession No.: 
AAO15434.1>

<400>  210

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  211
<211>  200
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CILIARY NEUROTROPHIC FACTOR (CNTF) <Accession No.: NP_000605.1>

<400>  211

Met Ala Phe Thr Glu His Ser Pro Leu Thr Pro His Arg Arg Asp Leu 
1               5                   10                  15      


Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Thr 
            20                  25                  30          


Ala Leu Thr Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 
        35                  40                  45              


Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Thr Asp Gln Trp 
    50                  55                  60                  


Ser Glu Leu Thr Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 
65                  70                  75                  80  


Arg Thr Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 
                85                  90                  95      


His Phe Thr Pro Thr Glu Gly Asp Phe His Gln Ala Ile His Thr Leu 
            100                 105                 110         


Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 
        115                 120                 125             


Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 
    130                 135                 140                 


Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 
145                 150                 155                 160 


Val Leu Gln Glu Leu Ser Gln Trp Thr Val Arg Ser Ile His Asp Leu 
                165                 170                 175     


Arg Phe Ile Ser Ser His Gln Thr Gly Ile Pro Ala Arg Gly Ser His 
            180                 185                 190         


Tyr Ile Ala Asn Asn Lys Lys Met 
        195                 200 


<210>  212
<211>  604
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 (PTGS2)
 <Accession No.: BAA05698.1>

<400>  212

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  213
<211>  359
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROSTAGLANDIN F RECEPTOR (PTGFR) <Accession No.: AAQ76788.1>

<400>  213

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Val Thr Met Ala Asn Ile 
            260                 265                 270         


Gly Ile Asn Gly Asn His Ser Leu Glu Thr Cys Glu Thr Thr Leu Phe 
        275                 280                 285             


Ala Leu Arg Met Ala Thr Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr 
    290                 295                 300                 


Ile Leu Leu Arg Lys Ala Val Leu Lys Asn Leu Tyr Lys Leu Ala Ser 
305                 310                 315                 320 


Gln Cys Cys Gly Val His Val Ile Ser Leu His Ile Trp Glu Leu Ser 
                325                 330                 335     


Ser Ile Lys Asn Ser Leu Lys Val Ala Ala Ile Ser Glu Ser Pro Val 
            340                 345                 350         


Ala Glu Lys Ser Ala Ser Thr 
        355                 


<210>  214
<211>  359
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROSTAGLANDIN F RECEPTOR (PTGFR), ISOFORM CRA_A 
<Accession No.: EAX06350.1>

<400>  214

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Val Thr Met Ala Asn Ile 
            260                 265                 270         


Gly Ile Asn Gly Asn His Ser Leu Glu Thr Cys Glu Thr Thr Leu Phe 
        275                 280                 285             


Ala Leu Arg Met Ala Thr Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr 
    290                 295                 300                 


Ile Leu Leu Arg Lys Ala Val Leu Lys Asn Leu Tyr Lys Leu Ala Ser 
305                 310                 315                 320 


Gln Cys Cys Gly Val His Val Ile Ser Leu His Ile Trp Glu Leu Ser 
                325                 330                 335     


Ser Ile Lys Asn Ser Leu Lys Val Ala Ala Ile Ser Glu Ser Pro Val 
            340                 345                 350         


Ala Glu Lys Ser Ala Ser Thr 
        355                 


<210>  215
<211>  297
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROSTAGLANDIN F RECEPTOR (PTGFR), ISOFORM CRA_B 
<Accession No.: EAX06351.1>

<400>  215

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Gly Tyr Arg Ile Ile Leu 
            260                 265                 270         


Asn Gly Lys Glu Lys Tyr Lys Val Tyr Glu Glu Gln Ser Asp Phe Leu 
        275                 280                 285             


His Arg Leu Gln Trp Pro Thr Leu Glu 
    290                 295         


<210>  216
<211>  463
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HYALURONIDASE  <Accession No.: AAC70915.1>

<400>  216

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala 
                165                 170                 175     


Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg 
            180                 185                 190         


Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly 
        195                 200                 205             


Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr 
    210                 215                 220                 


Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala 
225                 230                 235                 240 


Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His 
                245                 250                 255     


Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu 
            260                 265                 270         


Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr 
        275                 280                 285             


His Arg Arg Ser Gly Arg Phe Leu Ser Gln Asp Asp Leu Val Gln Ser 
    290                 295                 300                 


Ile Gly Val Ser Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp Gly 
305                 310                 315                 320 


Asp Leu Ser Leu Ser Ser Ser Glu Glu Glu Cys Trp His Leu His Asp 
                325                 330                 335     


Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Arg Ala 
            340                 345                 350         


Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala 
        355                 360                 365             


Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp Pro Asp 
    370                 375                 380                 


Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr Trp Gly 
385                 390                 395                 400 


Trp Ala Gly Pro Thr Cys Gln Glu Pro Ser Leu Gly Leu Lys Lys Gln 
                405                 410                 415     


Tyr Lys Ala Arg Ala Pro Ala Thr Ala Ser Ser Phe Pro Cys Cys His 
            420                 425                 430         


Phe Ser Ser Pro Gly Thr Thr Leu Ser His Ser Cys Ser Ile Gln Phe 
        435                 440                 445             


Thr Val Asn Pro Pro Lys His Thr Pro Arg Phe Pro Trp Asn Pro 
    450                 455                 460             


<210>  217
<211>  418
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF); 
<Accession No.: P36955.4>

<400>  217

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  218
<211>  418
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF); ISOFORM 1 
PRECURSOR <Accession No.: NP_001316832.1>

<400>  218

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  219
<211>  231
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF); ISOFORM 2  
<Accession No.: NP_001316834.1>

<400>  219

Met Lys Gly Lys Leu Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile 
1               5                   10                  15      


Ser Ile Leu Leu Leu Gly Val Ala His Phe Lys Gly Gln Trp Val Thr 
            20                  25                  30          


Lys Phe Asp Ser Arg Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu 
        35                  40                  45              


Glu Arg Thr Val Arg Val Pro Met Met Ser Asp Pro Lys Ala Val Leu 
    50                  55                  60                  


Arg Tyr Gly Leu Asp Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro 
65                  70                  75                  80  


Leu Thr Gly Ser Met Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr 
                85                  90                  95      


Gln Asn Leu Thr Leu Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His 
            100                 105                 110         


Asp Ile Asp Arg Glu Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro 
        115                 120                 125             


Lys Leu Lys Leu Ser Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu 
    130                 135                 140                 


Met Lys Leu Gln Ser Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr 
145                 150                 155                 160 


Gly Lys Pro Ile Lys Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu 
                165                 170                 175     


Trp Asn Glu Asp Gly Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro 
            180                 185                 190         


Ala His Leu Thr Phe Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile 
        195                 200                 205             


Phe Val Leu Arg Asp Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys 
    210                 215                 220                 


Ile Leu Asp Pro Arg Gly Pro 
225                 230     


<210>  220
<211>  191
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) 
<Accession No.: CAA44447.1>

<400>  220

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210>  221
<211>  170
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PLACENTAL GROWTH FACTOR (PGF)  <Accession No.: AAH07789.1>

<400>  221

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro 
    130                 135                 140                 


Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys 
145                 150                 155                 160 


His Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 170 


<210>  222
<211>  490
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOCILIN (MYOC) <Accession No.: BAA24532.1>

<400>  222

Met Pro Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val 
1               5                   10                  15      


Gly Ala Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg 
            20                  25                  30          


Cys Gln Tyr Thr Phe Ser Val Ala Ser Pro Asn Glu Ser Ser Cys Pro 
        35                  40                  45              


Glu Gln Ser Gln Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser 
    50                  55                  60                  


Ser Thr Gln Arg Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser 
65                  70                  75                  80  


Leu Glu Ser Leu Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro 
                85                  90                  95      


Gln Glu Thr Gln Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg 
            100                 105                 110         


Glu Arg Asp Gln Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr 
        115                 120                 125             


Ser Asn Leu Leu Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg 
    130                 135                 140                 


Leu Arg Gln Glu Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser 
145                 150                 155                 160 


Gln Glu Val Ala Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp 
                165                 170                 175     


Thr Ala Arg Ala Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn 
            180                 185                 190         


Leu Asp Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val 
        195                 200                 205             


Pro Ala Ser Arg Ile Leu Lys Glu Ser Pro Ser Gly Tyr Leu Arg Ser 
    210                 215                 220                 


Gly Glu Gly Asp Thr Gly Cys Gly Glu Leu Val Trp Val Gly Glu Pro 
225                 230                 235                 240 


Leu Thr Leu Arg Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp 
                245                 250                 255     


Met Arg Asp Pro Lys Pro Thr Tyr Pro Tyr Thr Gln Glu Thr Thr Trp 
            260                 265                 270         


Arg Ile Asp Thr Val Gly Thr Asp Val Arg Gln Val Phe Glu Tyr Asp 
        275                 280                 285             


Leu Ile Ser Gln Phe Met Gln Gly Tyr Pro Ser Lys Val His Ile Leu 
    290                 295                 300                 


Pro Arg Pro Leu Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu 
305                 310                 315                 320 


Tyr Phe Gln Gly Ala Glu Ser Arg Thr Val Ile Arg Tyr Glu Leu Asn 
                325                 330                 335     


Thr Glu Thr Val Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His 
            340                 345                 350         


Gly Gln Phe Pro Tyr Ser Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala 
        355                 360                 365             


Val Asp Glu Ala Gly Leu Trp Val Ile Tyr Ser Thr Asp Glu Ala Lys 
    370                 375                 380                 


Gly Ala Ile Val Leu Ser Lys Leu Asn Pro Glu Asn Leu Glu Leu Glu 
385                 390                 395                 400 


Gln Thr Trp Glu Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe 
                405                 410                 415     


Ile Ile Cys Gly Thr Leu Tyr Thr Val Ser Ser Tyr Thr Ser Ala Asp 
            420                 425                 430         


Ala Thr Val Asn Phe Ala Tyr Asp Thr Gly Thr Gly Ile Ser Lys Thr 
        435                 440                 445             


Leu Thr Ile Pro Phe Lys Asn Arg Tyr Lys Tyr Ser Ser Met Ile Asp 
    450                 455                 460                 


Tyr Asn Pro Leu Glu Lys Lys Leu Phe Ala Trp Asp Asn Leu Asn Met 
465                 470                 475                 480 


Val Thr Tyr Asp Ile Lys Leu Ser Lys Met 
                485                 490 


<210>  223
<211>  352
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C-C MOTIF CHEMOKINE RECEPTOR 5 (CCR5)  <Accession No.: 
NP_001093638.1>

<400>  223

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  224
<211>  557
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD19  <Accession No.: AAB60697.1>

<400>  224

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Gly Glu Gly 
            20                  25                  30          


Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr 
        35                  40                  45              


Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys 
    50                  55                  60                  


Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala 
65                  70                  75                  80  


Ser Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr 
                85                  90                  95      


Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp 
            100                 105                 110         


Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser 
        115                 120                 125             


Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly 
    130                 135                 140                 


Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp 
145                 150                 155                 160 


Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro 
                165                 170                 175     


Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala 
            180                 185                 190         


Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val 
        195                 200                 205             


Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys 
    210                 215                 220                 


Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met 
225                 230                 235                 240 


Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp 
                245                 250                 255     


Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His 
            260                 265                 270         


Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr 
        275                 280                 285             


Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys 
    290                 295                 300                 


Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu 
305                 310                 315                 320 


Arg Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys 
                325                 330                 335     


Val Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val 
            340                 345                 350         


Leu Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp 
        355                 360                 365             


Ala Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser 
    370                 375                 380                 


Asp Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val 
385                 390                 395                 400 


Gly Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu 
                405                 410                 415     


Glu Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln 
            420                 425                 430         


Leu Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu 
        435                 440                 445             


Gly Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn 
    450                 455                 460                 


Glu Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu 
465                 470                 475                 480 


Ser Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu 
                485                 490                 495     


Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro 
            500                 505                 510         


Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp 
        515                 520                 525             


Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala 
    530                 535                 540                 


Trp Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555         


<210>  225
<211>  1285
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CRUMBS CELL POLARITY COMPLEX COMPONENT 2 (CRB2), 
PRECURSOR <Accession No.: NP_775960.4>

<400>  225

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Thr Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Thr Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Thr  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Leu Pro Val Pro Ser  Lys Glu Cys Ser Leu  Asn Val Thr 
    1130                 1135                 1140             


Cys Leu  Asp Gly Ser Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn 
    1145                 1150                 1155             


Cys Ser  Cys Leu Glu Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro 
    1160                 1165                 1170             


Thr Leu  Pro Cys Glu Ala Asn  Pro Cys Leu Asn Gly  Gly Thr Cys 
    1175                 1180                 1185             


Arg Ala  Ala Gly Gly Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe 
    1190                 1195                 1200             


Ser Gly  Gln Phe Cys Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu 
    1205                 1210                 1215             


Pro Phe  Pro Leu Leu Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Leu Leu  Leu Leu Leu Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala 
    1235                 1240                 1245             


Arg Lys  Arg Arg Gln Ser Glu  Gly Thr Tyr Ser Pro  Ser Gln Gln 
    1250                 1255                 1260             


Glu Val  Ala Gly Ala Arg Leu  Glu Met Asp Ser Val  Leu Lys Val 
    1265                 1270                 1275             


Pro Pro  Glu Glu Arg Leu Ile  
    1280                 1285 


<210>  226
<211>  1276
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CRUMBS CELL POLARITY COMPLEX COMPONENT 2 (CRB2), 
ISOFORM X1 <Accession No.: XP_011516858.1>

<400>  226

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Val Ala Glu Ala Thr 
    850                 855                 860                 


Phe Arg Glu Gly Pro Pro Ala Ala Phe Ser Gly His Asn Ala Ser Ser 
865                 870                 875                 880 


Gly Arg Leu Leu Gly Gly Leu Ser Leu Ala Phe Arg Thr Arg Asp Ser 
                885                 890                 895     


Glu Ala Trp Leu Leu Arg Ala Ala Ala Gly Ala Leu Glu Gly Val Trp 
            900                 905                 910         


Leu Ala Val Arg Asn Gly Ser Leu Ala Gly Gly Val Arg Gly Gly His 
        915                 920                 925             


Gly Leu Pro Gly Ala Val Leu Pro Ile Pro Gly Pro Arg Val Ala Asp 
    930                 935                 940                 


Gly Ala Trp His Arg Val Arg Leu Ala Met Glu Arg Pro Ala Ala Thr 
945                 950                 955                 960 


Thr Ser Arg Trp Leu Leu Trp Leu Asp Gly Ala Ala Thr Pro Val Ala 
                965                 970                 975     


Leu Arg Gly Leu Ala Ser Asp Leu Gly Phe Leu Gln Gly Pro Gly Ala 
            980                 985                 990         


Val Arg Ile Leu Leu Ala Glu Asn  Phe Thr Gly Cys Leu  Gly Arg Val 
        995                 1000                 1005             


Ala Leu  Gly Gly Leu Pro Leu  Pro Leu Ala Arg Pro  Arg Pro Gly 
    1010                 1015                 1020             


Ala Ala  Pro Gly Ala Arg Glu  His Phe Ala Ser Trp  Pro Gly Thr 
    1025                 1030                 1035             


Pro Ala  Pro Ile Leu Gly Cys  Arg Gly Ala Pro Val  Cys Ala Pro 
    1040                 1045                 1050             


Ser Pro  Cys Leu His Asp Gly  Ala Cys Arg Asp Leu  Phe Asp Ala 
    1055                 1060                 1065             


Phe Ala  Cys Ala Cys Gly Pro  Gly Trp Glu Gly Pro  Arg Cys Glu 
    1070                 1075                 1080             


Ala His  Val Asp Pro Cys His  Ser Ala Pro Cys Ala  Arg Gly Arg 
    1085                 1090                 1095             


Cys His  Thr His Pro Asp Gly  Arg Phe Glu Cys Arg  Cys Pro Pro 
    1100                 1105                 1110             


Gly Phe  Gly Gly Pro Arg Cys  Arg Leu Pro Val Pro  Ser Lys Glu 
    1115                 1120                 1125             


Cys Ser  Leu Asn Val Thr Cys  Leu Asp Gly Ser Pro  Cys Glu Gly 
    1130                 1135                 1140             


Gly Ser  Pro Ala Ala Asn Cys  Ser Cys Leu Glu Gly  Leu Ala Gly 
    1145                 1150                 1155             


Gln Arg  Cys Gln Val Pro Thr  Leu Pro Cys Glu Ala  Asn Pro Cys 
    1160                 1165                 1170             


Leu Asn  Gly Gly Thr Cys Arg  Ala Ala Gly Gly Val  Ser Glu Cys 
    1175                 1180                 1185             


Ile Cys  Asn Ala Arg Phe Ser  Gly Gln Phe Cys Glu  Val Ala Lys 
    1190                 1195                 1200             


Gly Leu  Pro Leu Pro Leu Pro  Phe Pro Leu Leu Glu  Val Ala Val 
    1205                 1210                 1215             


Pro Ala  Ala Cys Ala Cys Leu  Leu Leu Leu Leu Leu  Gly Leu Leu 
    1220                 1225                 1230             


Ser Gly  Ile Leu Ala Ala Arg  Lys Arg Arg Gln Ser  Glu Gly Thr 
    1235                 1240                 1245             


Tyr Ser  Pro Ser Gln Gln Glu  Val Ala Gly Ala Arg  Leu Glu Met 
    1250                 1255                 1260             


Asp Ser  Val Leu Lys Val Pro  Pro Glu Glu Arg Leu  Ile 
    1265                 1270                 1275     


<210>  227
<211>  1220
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CRUMBS CELL POLARITY COMPLEX COMPONENT 2 (CRB2), 
ISOFORM X2 <Accession No.: XP_011516860.1>

<400>  227

Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala Leu 
1               5                   10                  15      


Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys Val 
            20                  25                  30          


Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys Ala 
        35                  40                  45              


Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp Arg 
    50                  55                  60                  


Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu Met 
65                  70                  75                  80  


Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser Cys 
                85                  90                  95      


Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr Gly 
            100                 105                 110         


Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro Cys 
        115                 120                 125             


Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys Asp 
    130                 135                 140                 


Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val Leu 
145                 150                 155                 160 


Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu Gly 
                165                 170                 175     


Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu Leu 
            180                 185                 190         


Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His Gly 
        195                 200                 205             


Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val Gln 
    210                 215                 220                 


Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe Leu 
225                 230                 235                 240 


Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu Val 
                245                 250                 255     


Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln Asp 
            260                 265                 270         


Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly Pro 
        275                 280                 285             


Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu His 
    290                 295                 300                 


Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys Pro 
305                 310                 315                 320 


Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys Gln 
                325                 330                 335     


Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu Ser 
            340                 345                 350         


Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly Pro 
        355                 360                 365             


Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro Ile 
    370                 375                 380                 


Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg Phe 
385                 390                 395                 400 


Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr Lys 
                405                 410                 415     


Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr Leu 
            420                 425                 430         


Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu Ala 
        435                 440                 445             


Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu Ala 
    450                 455                 460                 


Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu Cys 
465                 470                 475                 480 


Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr Pro 
                485                 490                 495     


Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe Ala 
            500                 505                 510         


Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro Glu 
        515                 520                 525             


Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln Cys 
    530                 535                 540                 


Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp Thr 
545                 550                 555                 560 


His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys Ala 
                565                 570                 575     


Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser Ser 
            580                 585                 590         


Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val Ser 
        595                 600                 605             


Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe Ala 
    610                 615                 620                 


Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg Ile 
625                 630                 635                 640 


Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg Trp 
                645                 650                 655     


Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp Gln 
            660                 665                 670         


Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu Ala 
        675                 680                 685             


Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln Asp 
    690                 695                 700                 


Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu Asp 
705                 710                 715                 720 


Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn Leu 
                725                 730                 735     


Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys Phe 
            740                 745                 750         


Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr Cys 
        755                 760                 765             


Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys Pro 
    770                 775                 780                 


Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp Gly 
785                 790                 795                 800 


Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala Ala 
                805                 810                 815     


Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu Ser 
            820                 825                 830         


Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala Ala 
        835                 840                 845             


Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser Leu 
    850                 855                 860                 


Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu Pro 
865                 870                 875                 880 


Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg Leu 
                885                 890                 895     


Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp Leu 
            900                 905                 910         


Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp Leu 
        915                 920                 925             


Gly Phe Leu Gln Gly Pro Gly Ala Val Arg Ile Leu Leu Ala Glu Asn 
    930                 935                 940                 


Phe Thr Gly Cys Leu Gly Arg Val Ala Leu Gly Gly Leu Pro Leu Pro 
945                 950                 955                 960 


Leu Ala Arg Pro Arg Pro Gly Ala Ala Pro Gly Ala Arg Glu His Phe 
                965                 970                 975     


Ala Ser Trp Pro Gly Thr Pro Ala Pro Ile Leu Gly Cys Arg Gly Ala 
            980                 985                 990         


Pro Val Cys Ala Pro Ser Pro Cys  Leu His Asp Gly Ala  Cys Arg Asp 
        995                 1000                 1005             


Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly Pro Gly  Trp Glu Gly 
    1010                 1015                 1020             


Pro Arg  Cys Glu Ala His Val  Asp Pro Cys His Ser  Ala Pro Cys 
    1025                 1030                 1035             


Ala Arg  Gly Arg Cys His Thr  His Pro Asp Gly Arg  Phe Glu Cys 
    1040                 1045                 1050             


Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg Cys Arg  Leu Pro Val 
    1055                 1060                 1065             


Pro Ser  Lys Glu Cys Ser Leu  Asn Val Thr Cys Leu  Asp Gly Ser 
    1070                 1075                 1080             


Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn Cys Ser  Cys Leu Glu 
    1085                 1090                 1095             


Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro Thr Leu  Pro Cys Glu 
    1100                 1105                 1110             


Ala Asn  Pro Cys Leu Asn Gly  Gly Thr Cys Arg Ala  Ala Gly Gly 
    1115                 1120                 1125             


Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe Ser Gly  Gln Phe Cys 
    1130                 1135                 1140             


Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu Pro Phe  Pro Leu Leu 
    1145                 1150                 1155             


Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys Leu Leu  Leu Leu Leu 
    1160                 1165                 1170             


Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala Arg Lys  Arg Arg Gln 
    1175                 1180                 1185             


Ser Glu  Gly Thr Tyr Ser Pro  Ser Gln Gln Glu Val  Ala Gly Ala 
    1190                 1195                 1200             


Arg Leu  Glu Met Asp Ser Val  Leu Lys Val Pro Pro  Glu Glu Arg 
    1205                 1210                 1215             


Leu Ile  
    1220 


<210>  228
<211>  1084
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) <Accession No.: NP_006028.2>

<400>  228

Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                  15      


Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                  25                  30          


Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                  40                  45              


Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                  55                  60                  


Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                  70                  75                  80  


Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                  90                  95      


His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                 105                 110         


Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                 120                 125             


Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                 135                 140                 


Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                 150                 155                 160 


Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                 170                 175     


Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                 185                 190         


His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His 
        195                 200                 205             


Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser 
    210                 215                 220                 


Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro 
225                 230                 235                 240 


Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu 
                245                 250                 255     


Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
            260                 265                 270         


Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr 
        275                 280                 285             


Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
    290                 295                 300                 


Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
305                 310                 315                 320 


Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
                325                 330                 335     


Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
            340                 345                 350         


Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
        355                 360                 365             


Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
    370                 375                 380                 


Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
385                 390                 395                 400 


Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His 
                405                 410                 415     


Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly 
            420                 425                 430         


Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg 
        435                 440                 445             


Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg 
    450                 455                 460                 


Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu 
465                 470                 475                 480 


Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln 
                485                 490                 495     


Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser 
            500                 505                 510         


Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu 
        515                 520                 525             


Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu 
    530                 535                 540                 


Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln 
545                 550                 555                 560 


Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val 
                565                 570                 575     


Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln 
            580                 585                 590         


Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr 
        595                 600                 605             


Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His 
    610                 615                 620                 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro 
625                 630                 635                 640 


Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu 
                645                 650                 655     


Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser 
            660                 665                 670         


Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg 
        675                 680                 685             


Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg 
    690                 695                 700                 


Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr 
705                 710                 715                 720 


Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys 
                725                 730                 735     


Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly 
            740                 745                 750         


Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala 
        755                 760                 765             


Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys 
    770                 775                 780                 


Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro 
785                 790                 795                 800 


Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn 
                805                 810                 815     


Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser 
            820                 825                 830         


Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln 
        835                 840                 845             


Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg 
    850                 855                 860                 


Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val 
865                 870                 875                 880 


Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly 
                885                 890                 895     


Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg 
            900                 905                 910         


Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu 
        915                 920                 925             


Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly 
    930                 935                 940                 


Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu 
945                 950                 955                 960 


Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His 
                965                 970                 975     


Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu 
            980                 985                 990         


Leu Gly Asn Glu Leu Asp Pro Leu  Pro Glu Lys Val Leu  Gln Gln Arg 
        995                 1000                 1005             


Pro Asn  Ala Asn Ala Val Arg  Ser Met Glu Lys Val  Met Glu Ile 
    1010                 1015                 1020             


His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg Thr Thr  Ser Thr Ala 
    1025                 1030                 1035             


Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys Glu Asn  Glu Glu Ala 
    1040                 1045                 1050             


Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser Val Gly  Val Lys Pro 
    1055                 1060                 1065             


Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met Glu Glu  Glu Pro Pro 
    1070                 1075                 1080             


Leu 
    


<210>  229
<211>  1108
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X2 
<Accession No.: XP_006712940.1>

<400>  229

Met Asn Ile Asp Leu Cys Ala Phe Glu Ile Gln Lys Thr Ser Ser Pro 
1               5                   10                  15      


Gly Tyr Glu Val Trp Phe Arg Lys Gln Tyr Leu Ala Val Asp Gly Asp 
            20                  25                  30          


Gly Leu Ser Gly Arg Asp Gln Pro Val Glu Leu Leu Asn Pro Ala Arg 
        35                  40                  45              


Val Asn His Met Pro Ser Thr Val Asp Val Ala Thr Ala Leu Pro Leu 
    50                  55                  60                  


Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln 
65                  70                  75                  80  


Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln 
                85                  90                  95      


Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile 
            100                 105                 110         


Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His 
        115                 120                 125             


Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala 
    130                 135                 140                 


Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg 
145                 150                 155                 160 


His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln Lys Leu 
                165                 170                 175     


Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala Val Ala Ser 
            180                 185                 190         


Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn Lys Lys Lys 
        195                 200                 205             


Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser Asp Pro Arg 
    210                 215                 220                 


Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln Ser Ser Pro 
225                 230                 235                 240 


Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val Leu Gly Met 
                245                 250                 255     


Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro 
            260                 265                 270         


Asn Leu Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg 
        275                 280                 285             


Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu 
    290                 295                 300                 


Lys Lys Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro 
305                 310                 315                 320 


Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala 
                325                 330                 335     


Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser 
            340                 345                 350         


Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro 
        355                 360                 365             


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
    370                 375                 380                 


Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu 
385                 390                 395                 400 


Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His 
                405                 410                 415     


Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala 
            420                 425                 430         


Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro 
        435                 440                 445             


Ala Gln Ala Pro Leu Val Thr Gly Leu Gly Ala Leu Pro Leu His Ala 
    450                 455                 460                 


Gln Ser Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu 
465                 470                 475                 480 


Arg Gln His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln 
                485                 490                 495     


Asn Ala Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln 
            500                 505                 510         


Phe Leu Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met 
        515                 520                 525             


Asn Lys Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser 
    530                 535                 540                 


His Pro Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu 
545                 550                 555                 560 


Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala 
                565                 570                 575     


Gln Ala Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu 
            580                 585                 590         


Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser 
        595                 600                 605             


Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln 
    610                 615                 620                 


Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly 
625                 630                 635                 640 


Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser 
                645                 650                 655     


Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr 
            660                 665                 670         


Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu Met Leu Lys 
        675                 680                 685             


His Gln Cys Thr Cys Gly Ser Ser Ser Ser His Pro Glu His Ala Gly 
    690                 695                 700                 


Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu Arg Gly 
705                 710                 715                 720 


Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu Glu Leu Gln 
                725                 730                 735     


Thr Val His Ser Glu Ala His Thr Leu Leu Tyr Gly Thr Asn Pro Leu 
            740                 745                 750         


Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu Leu Gly Ser Leu Ala Ser 
        755                 760                 765             


Val Phe Val Arg Leu Pro Cys Gly Gly Val Gly Val Asp Ser Asp Thr 
    770                 775                 780                 


Ile Trp Asn Glu Val His Ser Ala Gly Ala Ala Arg Leu Ala Val Gly 
785                 790                 795                 800 


Cys Val Val Glu Leu Val Phe Lys Val Ala Thr Gly Glu Leu Lys Asn 
                805                 810                 815     


Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Glu Glu Ser Thr 
            820                 825                 830         


Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu 
        835                 840                 845             


Leu Gln Gln Arg Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp 
    850                 855                 860                 


Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser 
865                 870                 875                 880 


Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro 
                885                 890                 895     


Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe 
            900                 905                 910         


Asn Val Asn Met Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp 
        915                 920                 925             


Ala Glu Tyr Leu Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser 
    930                 935                 940                 


Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val 
945                 950                 955                 960 


Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys 
                965                 970                 975     


Phe Gly Tyr Leu Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile 
            980                 985                 990         


Val Leu Ala Leu Glu Gly Gly His  Asp Leu Thr Ala Ile  Cys Asp Ala 
        995                 1000                 1005             


Ser Glu  Ala Cys Val Ser Ala  Leu Leu Gly Asn Glu  Leu Asp Pro 
    1010                 1015                 1020             


Leu Pro  Glu Lys Val Leu Gln  Gln Arg Pro Asn Ala  Asn Ala Val 
    1025                 1030                 1035             


Arg Ser  Met Glu Lys Val Met  Glu Ile His Ser Lys  Tyr Trp Arg 
    1040                 1045                 1050             


Cys Leu  Gln Arg Thr Thr Ser  Thr Ala Gly Arg Ser  Leu Ile Glu 
    1055                 1060                 1065             


Ala Gln  Thr Cys Glu Asn Glu  Glu Ala Glu Thr Val  Thr Ala Met 
    1070                 1075                 1080             


Ala Ser  Leu Ser Val Gly Val  Lys Pro Ala Glu Lys  Arg Pro Asp 
    1085                 1090                 1095             


Glu Glu  Pro Met Glu Glu Glu  Pro Pro Leu 
    1100                 1105             


<210>  230
<211>  1108
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X3 <Accession 
No.: XP_011510520.1>

<400>  230

Met Asn Ile Asp Leu Cys Ala Phe Glu Ile Gln Lys Thr Ser Ser Pro 
1               5                   10                  15      


Gly Tyr Glu Val Trp Phe Arg Lys Gln Tyr Leu Ala Val Asp Gly Asp 
            20                  25                  30          


Gly Leu Ser Gly Arg Asp Gln Pro Val Glu Leu Leu Asn Pro Ala Arg 
        35                  40                  45              


Val Asn His Met Pro Ser Thr Val Asp Val Ala Thr Ala Leu Pro Leu 
    50                  55                  60                  


Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln 
65                  70                  75                  80  


Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln 
                85                  90                  95      


Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile 
            100                 105                 110         


Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His 
        115                 120                 125             


Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala 
    130                 135                 140                 


Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg 
145                 150                 155                 160 


His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln Lys Leu 
                165                 170                 175     


Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala Val Ala Ser 
            180                 185                 190         


Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn Lys Lys Lys 
        195                 200                 205             


Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser Asp Pro Arg 
    210                 215                 220                 


Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln Ser Ser Pro 
225                 230                 235                 240 


Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val Leu Gly Met 
                245                 250                 255     


Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro 
            260                 265                 270         


Asn Leu Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg 
        275                 280                 285             


Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu 
    290                 295                 300                 


Lys Lys Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro 
305                 310                 315                 320 


Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala 
                325                 330                 335     


Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser 
            340                 345                 350         


Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro 
        355                 360                 365             


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
    370                 375                 380                 


Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu 
385                 390                 395                 400 


Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His 
                405                 410                 415     


Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala 
            420                 425                 430         


Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro 
        435                 440                 445             


Ala Gln Ala Pro Leu Val Thr Asp Trp Tyr Leu Ser Gly Leu Gly Ala 
    450                 455                 460                 


Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg Val Ser Pro 
465                 470                 475                 480 


Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg Thr Gln Ser 
                485                 490                 495     


Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu Val Ile Gln 
            500                 505                 510         


Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln Phe Gln Gln 
        515                 520                 525             


Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser Glu Pro Ala 
    530                 535                 540                 


Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu Leu Arg Glu 
545                 550                 555                 560 


His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly Gln 
                565                 570                 575     


Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln Glu Pro Ile 
            580                 585                 590         


Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly 
        595                 600                 605             


Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu 
    610                 615                 620                 


Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser 
625                 630                 635                 640 


Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu 
                645                 650                 655     


Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val 
            660                 665                 670         


Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp 
        675                 680                 685             


Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser Ser His 
    690                 695                 700                 


Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu 
705                 710                 715                 720 


Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr 
                725                 730                 735     


Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr 
            740                 745                 750         


Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Ser Leu Ala Ser 
        755                 760                 765             


Val Phe Val Arg Leu Pro Cys Gly Gly Val Gly Val Asp Ser Asp Thr 
    770                 775                 780                 


Ile Trp Asn Glu Val His Ser Ala Gly Ala Ala Arg Leu Ala Val Gly 
785                 790                 795                 800 


Cys Val Val Glu Leu Val Phe Lys Val Ala Thr Gly Glu Leu Lys Asn 
                805                 810                 815     


Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Glu Glu Ser Thr 
            820                 825                 830         


Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu 
        835                 840                 845             


Leu Gln Gln Arg Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp 
    850                 855                 860                 


Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser 
865                 870                 875                 880 


Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro 
                885                 890                 895     


Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe 
            900                 905                 910         


Asn Val Asn Met Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp 
        915                 920                 925             


Ala Glu Tyr Leu Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser 
    930                 935                 940                 


Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val 
945                 950                 955                 960 


Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys 
                965                 970                 975     


Phe Gly Tyr Leu Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile 
            980                 985                 990         


Val Leu Ala Leu Glu Gly Gly His  Asp Leu Thr Ala Ile  Cys Asp Ala 
        995                 1000                 1005             


Ser Glu  Ala Cys Val Ser Ala  Leu Leu Gly Asn Glu  Leu Asp Pro 
    1010                 1015                 1020             


Leu Pro  Glu Lys Val Leu Gln  Gln Arg Pro Asn Ala  Asn Ala Val 
    1025                 1030                 1035             


Arg Ser  Met Glu Lys Val Met  Glu Ile His Ser Lys  Tyr Trp Arg 
    1040                 1045                 1050             


Cys Leu  Gln Arg Thr Thr Ser  Thr Ala Gly Arg Ser  Leu Ile Glu 
    1055                 1060                 1065             


Ala Gln  Thr Cys Glu Asn Glu  Glu Ala Glu Thr Val  Thr Ala Met 
    1070                 1075                 1080             


Ala Ser  Leu Ser Val Gly Val  Lys Pro Ala Glu Lys  Arg Pro Asp 
    1085                 1090                 1095             


Glu Glu  Pro Met Glu Glu Glu  Pro Pro Leu 
    1100                 1105             


<210>  231
<211>  1103
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X4 <Accession
 No.: XP_011510521.1>

<400>  231

Met Asn Ile Asp Leu Cys Ala Phe Glu Ile Gln Lys Thr Ser Ser Pro 
1               5                   10                  15      


Gly Tyr Glu Val Trp Phe Arg Lys Gln Tyr Leu Ala Val Asp Gly Asp 
            20                  25                  30          


Gly Leu Ser Gly Arg Asp Gln Pro Val Glu Leu Leu Asn Pro Ala Arg 
        35                  40                  45              


Val Asn His Met Pro Ser Thr Val Asp Val Ala Thr Ala Leu Pro Leu 
    50                  55                  60                  


Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln 
65                  70                  75                  80  


Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln 
                85                  90                  95      


Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile 
            100                 105                 110         


Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His 
        115                 120                 125             


Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala 
    130                 135                 140                 


Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg 
145                 150                 155                 160 


His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln Lys Leu 
                165                 170                 175     


Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala Val Ala Ser 
            180                 185                 190         


Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn Lys Lys Lys 
        195                 200                 205             


Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser Asp Pro Arg 
    210                 215                 220                 


Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln Ser Ser Pro 
225                 230                 235                 240 


Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val Leu Gly Met 
                245                 250                 255     


Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro 
            260                 265                 270         


Asn Leu Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg 
        275                 280                 285             


Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu 
    290                 295                 300                 


Lys Lys Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro 
305                 310                 315                 320 


Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala 
                325                 330                 335     


Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser 
            340                 345                 350         


Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro 
        355                 360                 365             


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
    370                 375                 380                 


Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu 
385                 390                 395                 400 


Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His 
                405                 410                 415     


Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala 
            420                 425                 430         


Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro 
        435                 440                 445             


Ala Gln Ala Pro Leu Val Thr Gly Leu Gly Ala Leu Pro Leu His Ala 
    450                 455                 460                 


Gln Ser Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu 
465                 470                 475                 480 


Arg Gln His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln 
                485                 490                 495     


Asn Ala Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln 
            500                 505                 510         


Phe Leu Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met 
        515                 520                 525             


Asn Lys Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser 
    530                 535                 540                 


His Pro Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu 
545                 550                 555                 560 


Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala 
                565                 570                 575     


Gln Ala Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu 
            580                 585                 590         


Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser 
        595                 600                 605             


Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln 
    610                 615                 620                 


Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly 
625                 630                 635                 640 


Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser 
                645                 650                 655     


Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr 
            660                 665                 670         


Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu Met Leu Lys 
        675                 680                 685             


His Gln Cys Thr Cys Gly Ser Ser Ser Ser His Pro Glu His Ala Gly 
    690                 695                 700                 


Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu Arg Gly 
705                 710                 715                 720 


Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu Glu Leu Gln 
                725                 730                 735     


Thr Val His Ser Glu Ala His Thr Leu Leu Tyr Gly Thr Asn Pro Leu 
            740                 745                 750         


Asn Arg Gln Lys Leu Asp Ser Ser Leu Ala Ser Val Phe Val Arg Leu 
        755                 760                 765             


Pro Cys Gly Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val 
    770                 775                 780                 


His Ser Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu 
785                 790                 795                 800 


Val Phe Lys Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val 
                805                 810                 815     


Arg Pro Pro Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys 
            820                 825                 830         


Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu 
        835                 840                 845             


Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn 
    850                 855                 860                 


Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser 
865                 870                 875                 880 


Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro 
                885                 890                 895     


Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala 
            900                 905                 910         


Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala 
        915                 920                 925             


Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp 
    930                 935                 940                 


Val Val Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr 
945                 950                 955                 960 


Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr 
                965                 970                 975     


Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu 
            980                 985                 990         


Gly Gly His Asp Leu Thr Ala Ile  Cys Asp Ala Ser Glu  Ala Cys Val 
        995                 1000                 1005             


Ser Ala  Leu Leu Gly Asn Glu  Leu Asp Pro Leu Pro  Glu Lys Val 
    1010                 1015                 1020             


Leu Gln  Gln Arg Pro Asn Ala  Asn Ala Val Arg Ser  Met Glu Lys 
    1025                 1030                 1035             


Val Met  Glu Ile His Ser Lys  Tyr Trp Arg Cys Leu  Gln Arg Thr 
    1040                 1045                 1050             


Thr Ser  Thr Ala Gly Arg Ser  Leu Ile Glu Ala Gln  Thr Cys Glu 
    1055                 1060                 1065             


Asn Glu  Glu Ala Glu Thr Val  Thr Ala Met Ala Ser  Leu Ser Val 
    1070                 1075                 1080             


Gly Val  Lys Pro Ala Glu Lys  Arg Pro Asp Glu Glu  Pro Met Glu 
    1085                 1090                 1095             


Glu Glu  Pro Pro Leu 
    1100             


<210>  232
<211>  1090
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X5 <Accession 
No.: XP_011510522.1>

<400>  232

Met Arg Lys Leu Gly Pro Arg Glu Asp Gly Leu Ser Gly Arg Asp Gln 
1               5                   10                  15      


Pro Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr 
            20                  25                  30          


Val Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val 
        35                  40                  45              


Pro Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu 
    50                  55                  60                  


Pro Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys 
65                  70                  75                  80  


Gln Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg 
                85                  90                  95      


Gln His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His 
            100                 105                 110         


Ile Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu 
        115                 120                 125             


Leu Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu 
    130                 135                 140                 


Glu Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu 
145                 150                 155                 160 


Lys Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu 
                165                 170                 175     


Gln Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu 
            180                 185                 190         


Asn His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln 
        195                 200                 205             


His Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr 
    210                 215                 220                 


Ser Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe 
225                 230                 235                 240 


Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg 
                245                 250                 255     


Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg 
            260                 265                 270         


Lys Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val 
        275                 280                 285             


Thr Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro 
    290                 295                 300                 


Asn Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala 
305                 310                 315                 320 


Val Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala 
                325                 330                 335     


Arg Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu 
            340                 345                 350         


Pro Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr 
        355                 360                 365             


Ala Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln 
    370                 375                 380                 


Arg Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr 
385                 390                 395                 400 


Ser Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln 
                405                 410                 415     


His Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr 
            420                 425                 430         


Asp Trp Tyr Leu Ser Gly Leu Gly Ala Leu Pro Leu His Ala Gln Ser 
        435                 440                 445             


Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu Arg Gln 
    450                 455                 460                 


His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala 
465                 470                 475                 480 


Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu 
                485                 490                 495     


Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met Asn Lys 
            500                 505                 510         


Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser His Pro 
        515                 520                 525             


Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu Asp Glu 
    530                 535                 540                 


Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala Gln Ala 
545                 550                 555                 560 


Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala 
                565                 570                 575     


Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln 
            580                 585                 590         


Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile 
        595                 600                 605             


His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly Ile Pro 
    610                 615                 620                 


Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro 
625                 630                 635                 640 


Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr Lys Pro 
                645                 650                 655     


Arg Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu Met Leu Lys His Gln 
            660                 665                 670         


Cys Thr Cys Gly Ser Ser Ser Ser His Pro Glu His Ala Gly Arg Ile 
        675                 680                 685             


Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys 
    690                 695                 700                 


Glu Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu Glu Leu Gln Thr Val 
705                 710                 715                 720 


His Ser Glu Ala His Thr Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg 
                725                 730                 735     


Gln Lys Leu Asp Ser Lys Lys Leu Leu Gly Ser Leu Ala Ser Val Phe 
            740                 745                 750         


Val Arg Leu Pro Cys Gly Gly Val Gly Val Asp Ser Asp Thr Ile Trp 
        755                 760                 765             


Asn Glu Val His Ser Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val 
    770                 775                 780                 


Val Glu Leu Val Phe Lys Val Ala Thr Gly Glu Leu Lys Asn Gly Phe 
785                 790                 795                 800 


Ala Val Val Arg Pro Pro Gly His His Ala Glu Glu Ser Thr Pro Met 
                805                 810                 815     


Gly Phe Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln 
            820                 825                 830         


Gln Arg Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp Val His 
        835                 840                 845             


His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu 
    850                 855                 860                 


Tyr Met Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser 
865                 870                 875                 880 


Gly Ala Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val 
                885                 890                 895     


Asn Met Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu 
            900                 905                 910         


Tyr Leu Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe 
        915                 920                 925             


Ala Pro Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly 
    930                 935                 940                 


His Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly 
945                 950                 955                 960 


Tyr Leu Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu 
                965                 970                 975     


Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu 
            980                 985                 990         


Ala Cys Val Ser Ala Leu Leu Gly  Asn Glu Leu Asp Pro  Leu Pro Glu 
        995                 1000                 1005             


Lys Val  Leu Gln Gln Arg Pro  Asn Ala Asn Ala Val  Arg Ser Met 
    1010                 1015                 1020             


Glu Lys  Val Met Glu Ile His  Ser Lys Tyr Trp Arg  Cys Leu Gln 
    1025                 1030                 1035             


Arg Thr  Thr Ser Thr Ala Gly  Arg Ser Leu Ile Glu  Ala Gln Thr 
    1040                 1045                 1050             


Cys Glu  Asn Glu Glu Ala Glu  Thr Val Thr Ala Met  Ala Ser Leu 
    1055                 1060                 1065             


Ser Val  Gly Val Lys Pro Ala  Glu Lys Arg Pro Asp  Glu Glu Pro 
    1070                 1075                 1080             


Met Glu  Glu Glu Pro Pro Leu  
    1085                 1090 


<210>  233
<211>  1089
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X6 
<Accession No.: XP_011510523.1>

<400>  233

Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                  15      


Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                  25                  30          


Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                  40                  45              


Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                  55                  60                  


Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                  70                  75                  80  


Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                  90                  95      


His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                 105                 110         


Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                 120                 125             


Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                 135                 140                 


Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                 150                 155                 160 


Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                 170                 175     


Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                 185                 190         


His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His 
        195                 200                 205             


Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser 
    210                 215                 220                 


Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro 
225                 230                 235                 240 


Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu 
                245                 250                 255     


Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
            260                 265                 270         


Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr 
        275                 280                 285             


Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
    290                 295                 300                 


Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
305                 310                 315                 320 


Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
                325                 330                 335     


Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
            340                 345                 350         


Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
        355                 360                 365             


Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
    370                 375                 380                 


Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
385                 390                 395                 400 


Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His 
                405                 410                 415     


Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Asp 
            420                 425                 430         


Trp Tyr Leu Ser Gly Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu 
        435                 440                 445             


Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu Arg Gln His 
    450                 455                 460                 


Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln 
465                 470                 475                 480 


Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu 
                485                 490                 495     


Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile 
            500                 505                 510         


Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu 
        515                 520                 525             


Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro 
    530                 535                 540                 


Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly 
545                 550                 555                 560 


Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu 
                565                 570                 575     


Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu 
            580                 585                 590         


Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His 
        595                 600                 605             


Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val 
    610                 615                 620                 


Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala 
625                 630                 635                 640 


Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg 
                645                 650                 655     


Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys 
            660                 665                 670         


Thr Cys Gly Ser Ser Ser Ser His Pro Glu His Ala Gly Arg Ile Gln 
        675                 680                 685             


Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu 
    690                 695                 700                 


Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His 
705                 710                 715                 720 


Ser Glu Ala His Thr Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln 
                725                 730                 735     


Lys Leu Asp Ser Lys Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val 
            740                 745                 750         


Arg Leu Pro Cys Gly Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn 
        755                 760                 765             


Glu Val His Ser Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val 
    770                 775                 780                 


Glu Leu Val Phe Lys Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala 
785                 790                 795                 800 


Val Val Arg Pro Pro Gly His His Ala Glu Glu Ser Thr Pro Met Gly 
                805                 810                 815     


Phe Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln 
            820                 825                 830         


Arg Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His 
        835                 840                 845             


Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr 
    850                 855                 860                 


Met Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly 
865                 870                 875                 880 


Ala Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn 
                885                 890                 895     


Met Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr 
            900                 905                 910         


Leu Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala 
        915                 920                 925             


Pro Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly His 
    930                 935                 940                 


Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr 
945                 950                 955                 960 


Leu Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala 
                965                 970                 975     


Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala 
            980                 985                 990         


Cys Val Ser Ala Leu Leu Gly Asn  Glu Leu Asp Pro Leu  Pro Glu Lys 
        995                 1000                 1005             


Val Leu  Gln Gln Arg Pro Asn  Ala Asn Ala Val Arg  Ser Met Glu 
    1010                 1015                 1020             


Lys Val  Met Glu Ile His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg 
    1025                 1030                 1035             


Thr Thr  Ser Thr Ala Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys 
    1040                 1045                 1050             


Glu Asn  Glu Glu Ala Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser 
    1055                 1060                 1065             


Val Gly  Val Lys Pro Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met 
    1070                 1075                 1080             


Glu Glu  Glu Pro Pro Leu 
    1085                 


<210>  234
<211>  1084
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X7 
<Accession No.: XP_011510526.1>

<400>  234

Met Phe Asp Gly Leu Ser Gly Arg Asp Gln Pro Val Glu Leu Leu Asn 
1               5                   10                  15      


Pro Ala Arg Val Asn His Met Pro Ser Thr Val Asp Val Ala Thr Ala 
            20                  25                  30          


Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu 
        35                  40                  45              


Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln 
    50                  55                  60                  


Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln 
65                  70                  75                  80  


Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser 
                85                  90                  95      


Arg Gln His Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu 
            100                 105                 110         


Met Leu Ala Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys 
        115                 120                 125             


Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu 
    130                 135                 140                 


Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala 
145                 150                 155                 160 


Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn 
                165                 170                 175     


Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser 
            180                 185                 190         


Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln 
        195                 200                 205             


Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val 
    210                 215                 220                 


Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala 
225                 230                 235                 240 


Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala 
                245                 250                 255     


Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val 
            260                 265                 270         


Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser 
        275                 280                 285             


Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser 
    290                 295                 300                 


Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala 
305                 310                 315                 320 


Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala 
                325                 330                 335     


Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly 
            340                 345                 350         


Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala 
        355                 360                 365             


Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro 
    370                 375                 380                 


Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp 
385                 390                 395                 400 


Gly Gly Ala Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu Glu 
                405                 410                 415     


Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Asp Trp Tyr Leu Ser Gly 
            420                 425                 430         


Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg 
        435                 440                 445             


Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg 
    450                 455                 460                 


Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu 
465                 470                 475                 480 


Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln 
                485                 490                 495     


Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser 
            500                 505                 510         


Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu 
        515                 520                 525             


Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu 
    530                 535                 540                 


Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln 
545                 550                 555                 560 


Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val 
                565                 570                 575     


Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln 
            580                 585                 590         


Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr 
        595                 600                 605             


Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His 
    610                 615                 620                 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro 
625                 630                 635                 640 


Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu 
                645                 650                 655     


Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser 
            660                 665                 670         


Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg 
        675                 680                 685             


Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg 
    690                 695                 700                 


Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr 
705                 710                 715                 720 


Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys 
                725                 730                 735     


Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly 
            740                 745                 750         


Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala 
        755                 760                 765             


Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys 
    770                 775                 780                 


Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro 
785                 790                 795                 800 


Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn 
                805                 810                 815     


Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser 
            820                 825                 830         


Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln 
        835                 840                 845             


Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg 
    850                 855                 860                 


Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val 
865                 870                 875                 880 


Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly 
                885                 890                 895     


Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg 
            900                 905                 910         


Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu 
        915                 920                 925             


Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly 
    930                 935                 940                 


Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu 
945                 950                 955                 960 


Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His 
                965                 970                 975     


Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu 
            980                 985                 990         


Leu Gly Asn Glu Leu Asp Pro Leu  Pro Glu Lys Val Leu  Gln Gln Arg 
        995                 1000                 1005             


Pro Asn  Ala Asn Ala Val Arg  Ser Met Glu Lys Val  Met Glu Ile 
    1010                 1015                 1020             


His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg Thr Thr  Ser Thr Ala 
    1025                 1030                 1035             


Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys Glu Asn  Glu Glu Ala 
    1040                 1045                 1050             


Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser Val Gly  Val Lys Pro 
    1055                 1060                 1065             


Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met Glu Glu  Glu Pro Pro 
    1070                 1075                 1080             


Leu 
    


<210>  235
<211>  1079
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X8 
<Accession No.: XP_011510527.1>

<400>  235

Met Phe Asp Gly Leu Ser Gly Arg Asp Gln Pro Val Glu Leu Leu Asn 
1               5                   10                  15      


Pro Ala Arg Val Asn His Met Pro Ser Thr Val Asp Val Ala Thr Ala 
            20                  25                  30          


Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu 
        35                  40                  45              


Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln 
    50                  55                  60                  


Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln 
65                  70                  75                  80  


Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser 
                85                  90                  95      


Arg Gln His Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu 
            100                 105                 110         


Met Leu Ala Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys 
        115                 120                 125             


Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu 
    130                 135                 140                 


Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala 
145                 150                 155                 160 


Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn 
                165                 170                 175     


Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser 
            180                 185                 190         


Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln 
        195                 200                 205             


Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val 
    210                 215                 220                 


Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala 
225                 230                 235                 240 


Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala 
                245                 250                 255     


Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val 
            260                 265                 270         


Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser 
        275                 280                 285             


Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser 
    290                 295                 300                 


Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala 
305                 310                 315                 320 


Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala 
                325                 330                 335     


Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly 
            340                 345                 350         


Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala 
        355                 360                 365             


Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro 
    370                 375                 380                 


Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp 
385                 390                 395                 400 


Gly Gly Ala Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu Glu 
                405                 410                 415     


Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly Leu Gly Ala Leu Pro 
            420                 425                 430         


Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile 
        435                 440                 445             


His Lys Leu Arg Gln His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro 
    450                 455                 460                 


Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln 
465                 470                 475                 480 


His Gln Gln Phe Leu Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln 
                485                 490                 495     


Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln 
            500                 505                 510         


Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln 
        515                 520                 525             


Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu 
    530                 535                 540                 


Ala His Ala Gln Ala Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser 
545                 550                 555                 560 


Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg 
                565                 570                 575     


Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu 
            580                 585                 590         


Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu 
        595                 600                 605             


Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg 
    610                 615                 620                 


Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu 
625                 630                 635                 640 


Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu 
                645                 650                 655     


Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser Ser His Pro Glu 
            660                 665                 670         


His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly 
        675                 680                 685             


Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu 
    690                 695                 700                 


Glu Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr Gly Thr 
705                 710                 715                 720 


Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu Leu Gly Ser 
                725                 730                 735     


Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly Gly Val Gly Val Asp 
            740                 745                 750         


Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala Gly Ala Ala Arg Leu 
        755                 760                 765             


Ala Val Gly Cys Val Val Glu Leu Val Phe Lys Val Ala Thr Gly Glu 
    770                 775                 780                 


Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Glu 
785                 790                 795                 800 


Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala Val Ala 
                805                 810                 815     


Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser Lys Ile Leu Ile Val 
            820                 825                 830         


Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser 
        835                 840                 845             


Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp Gly Asn 
    850                 855                 860                 


Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly Pro Gly 
865                 870                 875                 880 


Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly Gly Leu Asp Pro Pro 
                885                 890                 895     


Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg Thr Val Val Met Pro 
            900                 905                 910         


Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser Gly Phe 
        915                 920                 925             


Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser 
    930                 935                 940                 


Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu Met Gly Leu Ala Gly 
945                 950                 955                 960 


Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile 
                965                 970                 975     


Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu Leu Gly Asn Glu Leu 
            980                 985                 990         


Asp Pro Leu Pro Glu Lys Val Leu  Gln Gln Arg Pro Asn  Ala Asn Ala 
        995                 1000                 1005             


Val Arg  Ser Met Glu Lys Val  Met Glu Ile His Ser  Lys Tyr Trp 
    1010                 1015                 1020             


Arg Cys  Leu Gln Arg Thr Thr  Ser Thr Ala Gly Arg  Ser Leu Ile 
    1025                 1030                 1035             


Glu Ala  Gln Thr Cys Glu Asn  Glu Glu Ala Glu Thr  Val Thr Ala 
    1040                 1045                 1050             


Met Ala  Ser Leu Ser Val Gly  Val Lys Pro Ala Glu  Lys Arg Pro 
    1055                 1060                 1065             


Asp Glu  Glu Pro Met Glu Glu  Glu Pro Pro Leu 
    1070                 1075                 


<210>  236
<211>  1069
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X9 <Accession 
No.: XP_016860883.1>

<400>  236

Met Asn Ile Asp Leu Cys Ala Phe Glu Ile Gln Lys Thr Ser Ser Pro 
1               5                   10                  15      


Gly Tyr Glu Val Trp Phe Arg Lys Gln Tyr Leu Ala Val Asp Gly Asp 
            20                  25                  30          


Gly Leu Ser Gly Arg Asp Gln Pro Val Glu Leu Leu Asn Pro Ala Arg 
        35                  40                  45              


Val Asn His Met Pro Ser Thr Val Asp Val Ala Thr Ala Leu Pro Leu 
    50                  55                  60                  


Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln 
65                  70                  75                  80  


Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln 
                85                  90                  95      


Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile 
            100                 105                 110         


Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His 
        115                 120                 125             


Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala 
    130                 135                 140                 


Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg 
145                 150                 155                 160 


His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln Lys Leu 
                165                 170                 175     


Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala Val Ala Ser 
            180                 185                 190         


Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn Lys Lys Lys 
        195                 200                 205             


Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser Asp Pro Arg 
    210                 215                 220                 


Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln Ser Ser Pro 
225                 230                 235                 240 


Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val Leu Gly Met 
                245                 250                 255     


Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Asp Ser Ala Cys 
            260                 265                 270         


Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly 
        275                 280                 285             


Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro 
    290                 295                 300                 


Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala 
305                 310                 315                 320 


Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu 
                325                 330                 335     


Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp 
            340                 345                 350         


Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe 
        355                 360                 365             


Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg 
    370                 375                 380                 


Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu 
385                 390                 395                 400 


Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Asp Trp Tyr Leu Ser 
                405                 410                 415     


Gly Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp 
            420                 425                 430         


Arg Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly 
        435                 440                 445             


Arg Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His 
    450                 455                 460                 


Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln 
465                 470                 475                 480 


Gln Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro 
                485                 490                 495     


Ser Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu 
            500                 505                 510         


Glu Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg 
        515                 520                 525             


Leu Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys 
    530                 535                 540                 


Gln Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu 
545                 550                 555                 560 


Val Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg 
                565                 570                 575     


Gln Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn 
            580                 585                 590         


Tyr Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly 
        595                 600                 605             


His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe 
    610                 615                 620                 


Pro Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly 
625                 630                 635                 640 


Leu Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser 
                645                 650                 655     


Ser Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser 
            660                 665                 670         


Arg Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly 
        675                 680                 685             


Arg Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His 
    690                 695                 700                 


Thr Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser 
705                 710                 715                 720 


Lys Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys 
                725                 730                 735     


Gly Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser 
            740                 745                 750         


Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe 
        755                 760                 765             


Lys Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro 
    770                 775                 780                 


Pro Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe 
785                 790                 795                 800 


Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val 
                805                 810                 815     


Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr 
            820                 825                 830         


Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His 
        835                 840                 845             


Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu 
    850                 855                 860                 


Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr 
865                 870                 875                 880 


Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe 
                885                 890                 895     


Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val 
            900                 905                 910         


Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu 
        915                 920                 925             


Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln 
    930                 935                 940                 


Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly 
945                 950                 955                 960 


His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala 
                965                 970                 975     


Leu Leu Gly Asn Glu Leu Asp Pro Leu Pro Glu Lys Val Leu Gln Gln 
            980                 985                 990         


Arg Pro Asn Ala Asn Ala Val Arg  Ser Met Glu Lys Val  Met Glu Ile 
        995                 1000                 1005             


His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg Thr Thr  Ser Thr Ala 
    1010                 1015                 1020             


Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys Glu Asn  Glu Glu Ala 
    1025                 1030                 1035             


Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser Val Gly  Val Lys Pro 
    1040                 1045                 1050             


Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met Glu Glu  Glu Pro Pro 
    1055                 1060                 1065             


Leu 
    


<210>  237
<211>  1065
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X10 <Accession 
No.: XP_011510528.1>

<400>  237

Met Ser Ser Gln Ser His Pro Val Asp Val Ala Thr Ala Leu Pro Leu 
1               5                   10                  15      


Gln Val Ala Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln 
            20                  25                  30          


Phe Ser Leu Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln 
        35                  40                  45              


Gln Glu Leu Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile 
    50                  55                  60                  


Leu Ile Ala Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His 
65                  70                  75                  80  


Glu Ala Gln Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala 
                85                  90                  95      


Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg 
            100                 105                 110         


His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln Lys Leu 
        115                 120                 125             


Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala Val Ala Ser 
    130                 135                 140                 


Thr Glu Val Lys Met Lys Leu Gln Glu Phe Val Leu Asn Lys Lys Lys 
145                 150                 155                 160 


Ala Leu Ala His Arg Asn Leu Asn His Cys Ile Ser Ser Asp Pro Arg 
                165                 170                 175     


Tyr Trp Tyr Gly Lys Thr Gln His Ser Ser Leu Asp Gln Ser Ser Pro 
            180                 185                 190         


Pro Gln Ser Gly Val Ser Thr Ser Tyr Asn His Pro Val Leu Gly Met 
        195                 200                 205             


Tyr Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro 
    210                 215                 220                 


Asn Leu Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg 
225                 230                 235                 240 


Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu 
                245                 250                 255     


Lys Lys Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro 
            260                 265                 270         


Gly Ser Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala 
        275                 280                 285             


Glu Asn Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser 
    290                 295                 300                 


Leu Ala His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Thr Gly Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu 
            340                 345                 350         


Thr Leu Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His 
        355                 360                 365             


Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala 
    370                 375                 380                 


Ala His Ser Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro 
385                 390                 395                 400 


Ala Gln Ala Pro Leu Val Thr Asp Trp Tyr Leu Ser Gly Leu Gly Ala 
                405                 410                 415     


Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg Val Ser Pro 
            420                 425                 430         


Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg Thr Gln Ser 
        435                 440                 445             


Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu Val Ile Gln 
    450                 455                 460                 


Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln Phe Gln Gln 
465                 470                 475                 480 


Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser Glu Pro Ala 
                485                 490                 495     


Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu Leu Arg Glu 
            500                 505                 510         


His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly Gln 
        515                 520                 525             


Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln Glu Pro Ile 
    530                 535                 540                 


Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly 
545                 550                 555                 560 


Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu 
                565                 570                 575     


Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser 
            580                 585                 590         


Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu 
        595                 600                 605             


Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val 
    610                 615                 620                 


Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp 
625                 630                 635                 640 


Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser Ser His 
                645                 650                 655     


Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu 
            660                 665                 670         


Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr 
        675                 680                 685             


Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr 
    690                 695                 700                 


Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu Leu 
705                 710                 715                 720 


Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly Gly Val Gly 
                725                 730                 735     


Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala Gly Ala Ala 
            740                 745                 750         


Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys Val Ala Thr 
        755                 760                 765             


Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His 
    770                 775                 780                 


Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala 
785                 790                 795                 800 


Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser Lys Ile Leu 
                805                 810                 815     


Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe 
            820                 825                 830         


Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp 
        835                 840                 845             


Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly 
    850                 855                 860                 


Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly Gly Leu Asp 
865                 870                 875                 880 


Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg Thr Val Val 
                885                 890                 895     


Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser 
            900                 905                 910         


Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn 
        915                 920                 925             


Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu Met Gly Leu 
    930                 935                 940                 


Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr 
945                 950                 955                 960 


Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu Leu Gly Asn 
                965                 970                 975     


Glu Leu Asp Pro Leu Pro Glu Lys Val Leu Gln Gln Arg Pro Asn Ala 
            980                 985                 990         


Asn Ala Val Arg Ser Met Glu Lys  Val Met Glu Ile His  Ser Lys Tyr 
        995                 1000                 1005             


Trp Arg  Cys Leu Gln Arg Thr  Thr Ser Thr Ala Gly  Arg Ser Leu 
    1010                 1015                 1020             


Ile Glu  Ala Gln Thr Cys Glu  Asn Glu Glu Ala Glu  Thr Val Thr 
    1025                 1030                 1035             


Ala Met  Ala Ser Leu Ser Val  Gly Val Lys Pro Ala  Glu Lys Arg 
    1040                 1045                 1050             


Pro Asp  Glu Glu Pro Met Glu  Glu Glu Pro Pro Leu  
    1055                 1060                 1065 


<210>  238
<211>  1062
<212>  PRT
<213>  Homo sapiens

<220>
<223>  HISTONE DEACETYLASE 4 (HDAC4) ISOFORM X11 <Accession 
No.: XP_006712943.1>

<400>  238

Met Pro Ser Thr Val Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala 
1               5                   10                  15      


Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu 
            20                  25                  30          


Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu 
        35                  40                  45              


Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala 
    50                  55                  60                  


Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His Glu Ala Gln 
65                  70                  75                  80  


Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala Met Lys His 
                85                  90                  95      


Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg His Arg Gln 
            100                 105                 110         


Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu 
        115                 120                 125             


Lys Asn Lys Glu Lys Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val 
    130                 135                 140                 


Lys Met Lys Leu Gln Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala 
145                 150                 155                 160 


His Arg Asn Leu Asn His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr 
                165                 170                 175     


Gly Lys Thr Gln His Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser 
            180                 185                 190         


Gly Val Ser Thr Ser Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala 
        195                 200                 205             


Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys 
    210                 215                 220                 


Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro 
225                 230                 235                 240 


Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg 
                245                 250                 255     


Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly 
            260                 265                 270         


Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly 
        275                 280                 285             


Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His 
    290                 295                 300                 


Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr 
305                 310                 315                 320 


Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro 
                325                 330                 335     


Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro 
            340                 345                 350         


Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro 
        355                 360                 365             


Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser 
    370                 375                 380                 


Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala 
385                 390                 395                 400 


Pro Leu Val Thr Asp Trp Tyr Leu Ser Gly Leu Gly Ala Leu Pro Leu 
                405                 410                 415     


His Ala Gln Ser Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile His 
            420                 425                 430         


Lys Leu Arg Gln His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu 
        435                 440                 445             


Pro Gln Asn Ala Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln His 
    450                 455                 460                 


Gln Gln Phe Leu Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu 
465                 470                 475                 480 


Gln Met Asn Lys Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro 
                485                 490                 495     


Glu Ser His Pro Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala 
            500                 505                 510         


Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala 
        515                 520                 525             


His Ala Gln Ala Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp 
    530                 535                 540                 


Glu Glu Glu Ala Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln 
545                 550                 555                 560 


Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu 
                565                 570                 575     


Gln Gln Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala 
            580                 585                 590         


Ala Gly Ile Pro Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala 
        595                 600                 605             


Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro 
    610                 615                 620                 


Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu Met 
625                 630                 635                 640 


Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser Ser His Pro Glu His 
                645                 650                 655     


Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu 
            660                 665                 670         


Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu Glu 
        675                 680                 685             


Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr Gly Thr Asn 
    690                 695                 700                 


Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu Leu Gly Ser Leu 
705                 710                 715                 720 


Ala Ser Val Phe Val Arg Leu Pro Cys Gly Gly Val Gly Val Asp Ser 
                725                 730                 735     


Asp Thr Ile Trp Asn Glu Val His Ser Ala Gly Ala Ala Arg Leu Ala 
            740                 745                 750         


Val Gly Cys Val Val Glu Leu Val Phe Lys Val Ala Thr Gly Glu Leu 
        755                 760                 765             


Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Glu Glu 
    770                 775                 780                 


Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala Val Ala Ala 
785                 790                 795                 800 


Lys Leu Leu Gln Gln Arg Leu Ser Val Ser Lys Ile Leu Ile Val Asp 
                805                 810                 815     


Trp Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp 
            820                 825                 830         


Pro Ser Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp Gly Asn Phe 
        835                 840                 845             


Phe Pro Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly Pro Gly Val 
    850                 855                 860                 


Gly Phe Asn Val Asn Met Ala Phe Thr Gly Gly Leu Asp Pro Pro Met 
865                 870                 875                 880 


Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg Thr Val Val Met Pro Ile 
                885                 890                 895     


Ala Ser Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser Gly Phe Asp 
            900                 905                 910         


Ala Val Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala 
        915                 920                 925             


Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu Met Gly Leu Ala Gly Gly 
    930                 935                 940                 


Arg Ile Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys 
945                 950                 955                 960 


Asp Ala Ser Glu Ala Cys Val Ser Ala Leu Leu Gly Asn Glu Leu Asp 
                965                 970                 975     


Pro Leu Pro Glu Lys Val Leu Gln Gln Arg Pro Asn Ala Asn Ala Val 
            980                 985                 990         


Arg Ser Met Glu Lys Val Met Glu  Ile His Ser Lys Tyr  Trp Arg Cys 
        995                 1000                 1005             


Leu Gln  Arg Thr Thr Ser Thr  Ala Gly Arg Ser Leu  Ile Glu Ala 
    1010                 1015                 1020             


Gln Thr  Cys Glu Asn Glu Glu  Ala Glu Thr Val Thr  Ala Met Ala 
    1025                 1030                 1035             


Ser Leu  Ser Val Gly Val Lys  Pro Ala Glu Lys Arg  Pro Asp Glu 
    1040                 1045                 1050             


Glu Pro  Met Glu Glu Glu Pro  Pro Leu 
    1055                 1060         


<210>  239
<211>  348
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RHODOPSIN (RHO) <Accession No.: NP_000530.1>

<400>  239

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  240
<211>  257
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NERVE GROWTH FACTOR (NGF) <Accession No.: CAA37703.1>

<400>  240

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  241
<211>  589
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NUCLEAR FACTOR, ERYTHROID 2 LIKE 2 (NRF2) <Accession 
No.: AAB32188.1>

<400>  241

Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
1               5                   10                  15      


Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
            20                  25                  30          


Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
        35                  40                  45              


Glu Gln Glu Lys Ala Phe Phe Thr Gln Leu Gln Leu Asp Glu Glu Thr 
    50                  55                  60                  


Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Thr Gln Ser Glu Thr 
65                  70                  75                  80  


Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
                85                  90                  95      


Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
            100                 105                 110         


Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
        115                 120                 125             


Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
    130                 135                 140                 


Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
145                 150                 155                 160 


Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
                165                 170                 175     


Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
            180                 185                 190         


Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
        195                 200                 205             


Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
    210                 215                 220                 


Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
225                 230                 235                 240 


Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
                245                 250                 255     


Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
            260                 265                 270         


Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
        275                 280                 285             


Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
    290                 295                 300                 


Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
305                 310                 315                 320 


Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
                325                 330                 335     


Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
            340                 345                 350         


Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
        355                 360                 365             


Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
    370                 375                 380                 


Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
385                 390                 395                 400 


Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
                405                 410                 415     


Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
            420                 425                 430         


Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
        435                 440                 445             


His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
    450                 455                 460                 


Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
465                 470                 475                 480 


Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
                485                 490                 495     


Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
            500                 505                 510         


Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
        515                 520                 525             


Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
    530                 535                 540                 


Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
545                 550                 555                 560 


Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
                565                 570                 575     


Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn 
            580                 585                 


<210>  242
<211>  210
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GLUTATHIONE S-TRANSFERASE PI 1 (GSTP1)  
<Accession No.: AAH10915.1>

<400>  242

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Val Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210>  243
<211>  212
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ROD-DERIVED CONE VIABILITY FACTOR (RDCVF) <Accession No.: 
NP_612463.1>

<400>  243

Met Ala Ser Leu Phe Ser Gly Arg Ile Leu Ile Arg Asn Asn Ser Asp 
1               5                   10                  15      


Gln Asp Glu Leu Asp Thr Glu Ala Glu Val Ser Arg Arg Leu Glu Asn 
            20                  25                  30          


Arg Leu Val Leu Leu Phe Phe Gly Ala Gly Ala Cys Pro Gln Cys Gln 
        35                  40                  45              


Ala Phe Val Pro Ile Leu Lys Asp Phe Phe Val Arg Leu Thr Asp Glu 
    50                  55                  60                  


Phe Tyr Val Leu Arg Ala Ala Gln Leu Ala Leu Val Tyr Val Ser Gln 
65                  70                  75                  80  


Asp Ser Thr Glu Glu Gln Gln Asp Leu Phe Leu Lys Asp Met Pro Lys 
                85                  90                  95      


Lys Trp Leu Phe Leu Pro Phe Glu Asp Asp Leu Arg Arg Asp Leu Gly 
            100                 105                 110         


Arg Gln Phe Ser Val Glu Arg Leu Pro Ala Val Val Val Leu Lys Pro 
        115                 120                 125             


Asp Gly Asp Val Leu Thr Arg Asp Gly Ala Asp Glu Ile Gln Arg Leu 
    130                 135                 140                 


Gly Thr Ala Cys Phe Ala Asn Trp Gln Glu Ala Ala Glu Val Leu Asp 
145                 150                 155                 160 


Arg Asn Phe Gln Leu Pro Glu Asp Leu Glu Asp Gln Glu Pro Arg Ser 
                165                 170                 175     


Leu Thr Glu Cys Leu Arg Arg His Lys Tyr Arg Val Glu Lys Ala Ala 
            180                 185                 190         


Arg Gly Gly Arg Asp Pro Gly Gly Gly Gly Gly Glu Glu Gly Gly Ala 
        195                 200                 205             


Gly Gly Leu Phe 
    210         


<210>  244
<211>  317
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINALDEHYDE BINDING PROTEIN 1 (RLBP1) <Accession No.: 
EAX02038.1>

<400>  244

Met Ser Glu Gly Val Gly Thr Phe Arg Met Val Pro Glu Glu Glu Gln 
1               5                   10                  15      


Glu Leu Arg Ala Gln Leu Glu Gln Leu Thr Thr Lys Asp His Gly Pro 
            20                  25                  30          


Val Phe Gly Pro Cys Ser Gln Leu Pro Arg His Thr Leu Gln Lys Ala 
        35                  40                  45              


Lys Asp Glu Leu Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 
    50                  55                  60                  


Glu Leu Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 
65                  70                  75                  80  


Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 
                85                  90                  95      


Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr Glu 
            100                 105                 110         


Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro Glu Leu Phe 
        115                 120                 125             


Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr Ile Glu Ala Gly Tyr 
    130                 135                 140                 


Pro Gly Val Leu Ser Ser Arg Asp Lys Tyr Gly Arg Val Val Met Leu 
145                 150                 155                 160 


Phe Asn Ile Glu Asn Trp Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 
                165                 170                 175     


Leu Gln Ala Tyr Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 
            180                 185                 190         


Thr Gln Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 
        195                 200                 205             


Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 
    210                 215                 220                 


Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His Phe 
225                 230                 235                 240 


Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn Val Val Lys Pro 
                245                 250                 255     


Phe Leu Lys Ser Lys Leu Leu Glu Arg Val Phe Val His Gly Asp Asp 
            260                 265                 270         


Leu Ser Gly Phe Tyr Gln Glu Ile Asp Glu Asn Ile Leu Pro Ser Asp 
        275                 280                 285             


Phe Gly Gly Thr Leu Pro Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 
    290                 295                 300                 


Leu Phe Gly Pro Gln Ala Gln Ala Glu Asn Thr Ala Phe 
305                 310                 315         


<210>  245
<211>  424
<212>  PRT
<213>  Homo sapiens

<220>
<223>  DOUBLE HOMEOBOX 4 (DUX4) <Accession No.: AUA60624.1>

<400>  245

Met Ala Leu Pro Thr Pro Ser Asp Ser Thr Leu Pro Ala Glu Ala Arg 
1               5                   10                  15      


Gly Arg Gly Arg Arg Arg Arg Leu Val Trp Thr Pro Ser Gln Ser Glu 
            20                  25                  30          


Ala Leu Arg Ala Cys Phe Glu Arg Asn Pro Tyr Pro Gly Ile Ala Thr 
        35                  40                  45              


Arg Glu Arg Leu Ala Gln Ala Ile Gly Ile Pro Glu Pro Arg Val Gln 
    50                  55                  60                  


Ile Trp Phe Gln Asn Glu Arg Ser Arg Gln Leu Arg Gln His Arg Arg 
65                  70                  75                  80  


Glu Ser Arg Pro Trp Pro Gly Arg Arg Gly Pro Pro Glu Gly Arg Arg 
                85                  90                  95      


Lys Arg Thr Ala Val Thr Gly Ser Gln Thr Ala Leu Leu Leu Arg Ala 
            100                 105                 110         


Phe Glu Lys Asp Arg Phe Pro Gly Ile Ala Ala Arg Glu Glu Leu Ala 
        115                 120                 125             


Arg Glu Thr Gly Leu Pro Glu Ser Arg Ile Gln Ile Trp Phe Gln Asn 
    130                 135                 140                 


Arg Arg Ala Arg His Pro Gly Gln Gly Gly Arg Ala Pro Ala Gln Ala 
145                 150                 155                 160 


Gly Gly Leu Cys Ser Ala Ala Pro Gly Gly Gly His Pro Ala Pro Ser 
                165                 170                 175     


Trp Val Ala Phe Ala His Thr Gly Ala Trp Gly Thr Gly Leu Pro Ala 
            180                 185                 190         


Pro His Val Pro Cys Ala Pro Gly Ala Leu Pro Gln Gly Ala Phe Val 
        195                 200                 205             


Ser Gln Ala Ala Arg Ala Ala Pro Ala Leu Gln Pro Ser Gln Ala Ala 
    210                 215                 220                 


Pro Ala Glu Gly Ile Ser Gln Pro Ala Pro Ala Arg Gly Asp Phe Ala 
225                 230                 235                 240 


Tyr Ala Ala Pro Ala Pro Pro Asp Gly Ala Leu Ser His Pro Gln Ala 
                245                 250                 255     


Pro Arg Trp Pro Pro His Pro Gly Lys Ser Arg Glu Asp Arg Asp Pro 
            260                 265                 270         


Gln Arg Asp Gly Leu Pro Gly Pro Cys Ala Val Ala Gln Pro Gly Pro 
        275                 280                 285             


Ala Gln Ala Gly Pro Gln Gly Gln Gly Val Leu Ala Pro Pro Thr Ser 
    290                 295                 300                 


Gln Gly Ser Pro Trp Trp Gly Trp Gly Arg Gly Pro Gln Val Ala Gly 
305                 310                 315                 320 


Thr Ala Trp Glu Pro Gln Ala Gly Ala Ala Pro Pro Pro Gln Pro Ala 
                325                 330                 335     


Pro Pro Asp Ala Ser Ala Ser Ala Arg Gln Gly Gln Met Gln Gly Ile 
            340                 345                 350         


Pro Ala Pro Ser Gln Ala Leu Gln Glu Pro Ala Pro Trp Ser Ala Leu 
        355                 360                 365             


Pro Cys Gly Leu Leu Leu Asp Glu Leu Leu Ala Ser Pro Glu Phe Leu 
    370                 375                 380                 


Gln Gln Ala Gln Pro Leu Leu Glu Thr Glu Ala Pro Gly Glu Leu Glu 
385                 390                 395                 400 


Ala Ser Glu Glu Ala Ala Ser Leu Glu Ala Pro Leu Ser Glu Glu Glu 
                405                 410                 415     


Tyr Arg Ala Leu Leu Glu Glu Leu 
            420                 


<210>  246
<211>  1016
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NLR FAMILY PYRIN DOMAIN CONTAINING 3 (NLRP3) <Accession 
No.: AAI43360.1>

<400>  246

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Cys Asn Gln Lys Leu Val Glu Leu Asp 
    770                 775                 780                 


Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val 
785                 790                 795                 800 


Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser 
                805                 810                 815     


Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser 
            820                 825                 830         


Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly 
        835                 840                 845             


Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys 
    850                 855                 860                 


Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys 
865                 870                 875                 880 


Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His 
                885                 890                 895     


Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu 
            900                 905                 910         


Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu 
        915                 920                 925             


Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu 
    930                 935                 940                 


Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp 
945                 950                 955                 960 


Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val Leu Lys Gln Gln 
                965                 970                 975     


Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr 
            980                 985                 990         


Glu Thr Lys Ser Ala Leu Glu Thr  Leu Gln Glu Glu Lys  Pro Glu Leu 
        995                 1000                 1005             


Thr Val  Val Phe Glu Pro Ser  Trp 
    1010                 1015     


<210>  247
<211>  612
<212>  PRT
<213>  Homo sapiens

<220>
<223>  SPLEEN ASSOCIATED TYROSINE KINASE (SYK), ISOFORM SYK(S) 
<Accession No.: NP_001167639.1>

<400>  247

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Ser Ser Pro Ala Gln Gly 
        275                 280                 285             


Asn Arg Gln Glu Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu Leu 
    290                 295                 300                 


Ala Pro Trp Ala Ala Asp Lys Gly Pro Gln Arg Glu Ala Leu Pro Met 
305                 310                 315                 320 


Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala Asp Pro Glu Glu Ile Arg 
                325                 330                 335     


Pro Lys Glu Val Tyr Leu Asp Arg Lys Leu Leu Thr Leu Glu Asp Lys 
            340                 345                 350         


Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys Lys Gly Tyr Tyr Gln 
        355                 360                 365             


Met Lys Lys Val Val Lys Thr Val Ala Val Lys Ile Leu Lys Asn Glu 
    370                 375                 380                 


Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu Ala Glu Ala Asn Val 
385                 390                 395                 400 


Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg Met Ile Gly Ile Cys 
                405                 410                 415     


Glu Ala Glu Ser Trp Met Leu Val Met Glu Met Ala Glu Leu Gly Pro 
            420                 425                 430         


Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Val Lys Asp Lys Asn Ile 
        435                 440                 445             


Ile Glu Leu Val His Gln Val Ser Met Gly Met Lys Tyr Leu Glu Glu 
    450                 455                 460                 


Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Val 
465                 470                 475                 480 


Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser Lys Ala Leu 
                485                 490                 495     


Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr His Gly Lys Trp Pro 
            500                 505                 510         


Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr Tyr Lys Phe Ser Ser 
        515                 520                 525             


Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ala Phe Ser 
    530                 535                 540                 


Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly Ser Glu Val Thr Ala 
545                 550                 555                 560 


Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro Ala Gly Cys Pro Arg 
                565                 570                 575     


Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr Tyr Asp Val Glu Asn 
            580                 585                 590         


Arg Pro Gly Phe Ala Ala Val Glu Leu Arg Leu Arg Asn Tyr Tyr Tyr 
        595                 600                 605             


Asp Val Val Asn 
    610         


<210>  248
<211>  635
<212>  PRT
<213>  Homo sapiens

<220>
<223>  SPLEEN ASSOCIATED TYROSINE KINASE (SYK), ISOFORM SYK(L) 
<Accession No.: NP_003168.2>

<400>  248

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly 
        275                 280                 285             


Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg 
    290                 295                 300                 


Lys Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe 
305                 310                 315                 320 


Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro 
                325                 330                 335     


Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr 
            340                 345                 350         


Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys 
        355                 360                 365             


Leu Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr 
    370                 375                 380                 


Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala 
385                 390                 395                 400 


Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu 
                405                 410                 415     


Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile 
            420                 425                 430         


Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met 
        435                 440                 445             


Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg 
    450                 455                 460                 


His Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met 
465                 470                 475                 480 


Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala 
                485                 490                 495     


Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp 
            500                 505                 510         


Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala 
        515                 520                 525             


Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile 
    530                 535                 540                 


Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val 
545                 550                 555                 560 


Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met 
                565                 570                 575     


Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly 
            580                 585                 590         


Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys 
        595                 600                 605             


Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu 
    610                 615                 620                 


Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
625                 630                 635 


<210>  249
<211>  267
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ADRENOCORTICOTROPIC HORMONE (ACTH), PREPROPROTEIN 
<Accession No.: NP_000930.1>

<400>  249

Met Pro Arg Ser Cys Cys Ser Arg Ser Gly Ala Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Gln Ala Ser Met Glu Val Arg Gly Trp Cys Leu Glu Ser Ser 
            20                  25                  30          


Gln Cys Gln Asp Leu Thr Thr Glu Ser Asn Leu Leu Glu Cys Ile Arg 
        35                  40                  45              


Ala Cys Lys Pro Asp Leu Ser Ala Glu Thr Pro Met Phe Pro Gly Asn 
    50                  55                  60                  


Gly Asp Glu Gln Pro Leu Thr Glu Asn Pro Arg Lys Tyr Val Met Gly 
65                  70                  75                  80  


His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Gly Ala Gly Gln Lys Arg Glu Asp Val Ser Ala Gly Glu Asp 
            100                 105                 110         


Cys Gly Pro Leu Pro Glu Gly Gly Pro Glu Pro Arg Ser Asp Gly Ala 
        115                 120                 125             


Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser Tyr Ser Met Glu His Phe 
    130                 135                 140                 


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
145                 150                 155                 160 


Pro Asn Gly Ala Glu Asp Glu Ser Ala Glu Ala Phe Pro Leu Glu Phe 
                165                 170                 175     


Lys Arg Glu Leu Thr Gly Gln Arg Leu Arg Glu Gly Asp Gly Pro Asp 
            180                 185                 190         


Gly Pro Ala Asp Asp Gly Ala Gly Ala Gln Ala Asp Leu Glu His Ser 
        195                 200                 205             


Leu Leu Val Ala Ala Glu Lys Lys Asp Glu Gly Pro Tyr Arg Met Glu 
    210                 215                 220                 


His Phe Arg Trp Gly Ser Pro Pro Lys Asp Lys Arg Tyr Gly Gly Phe 
225                 230                 235                 240 


Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr Leu Phe Lys Asn 
                245                 250                 255     


Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu 
            260                 265         


<210>  250
<211>  404
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CASPASE 1 (CASP1), ISOFORM ALPHA PRECURSOR 
<Accession No.: NP_001244047.1>

<400>  250

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Asp Gln Thr Ser Gly 
                85                  90                  95      


Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val Leu Ser Ser Phe Pro 
            100                 105                 110         


Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly 
        115                 120                 125             


Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile 
    130                 135                 140                 


Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser 
145                 150                 155                 160 


Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile 
                165                 170                 175     


Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu 
            180                 185                 190         


Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala 
        195                 200                 205             


Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg Pro Glu His 
    210                 215                 220                 


Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Arg 
225                 230                 235                 240 


Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu 
                245                 250                 255     


Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser 
            260                 265                 270         


Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp 
        275                 280                 285             


Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn 
    290                 295                 300                 


Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys 
305                 310                 315                 320 


Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp 
                325                 330                 335     


Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe Ile Gly Arg 
            340                 345                 350         


Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu 
        355                 360                 365             


Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala 
    370                 375                 380                 


Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu 
385                 390                 395                 400 


Phe Pro Gly His 
                


<210>  251
<211>  383
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CASPASE 1 (CASP1), ISOFORM BETA PRECURSOR <Accession 
No.: NP_001244048.1>

<400>  251

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Ala Pro Gln Ala Val 
                85                  90                  95      


Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val 
            100                 105                 110         


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
        115                 120                 125             


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala 
    130                 135                 140                 


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly 
145                 150                 155                 160 


Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly 
                165                 170                 175     


Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr 
            180                 185                 190         


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser 
        195                 200                 205             


Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
    210                 215                 220                 


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
225                 230                 235                 240 


Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
                245                 250                 255     


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
            260                 265                 270         


Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Thr 
        275                 280                 285             


Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys 
    290                 295                 300                 


Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val Ser Trp Arg 
305                 310                 315                 320 


His Pro Thr Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met 
                325                 330                 335     


Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val 
            340                 345                 350         


Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Thr Thr 
        355                 360                 365             


Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu Phe Pro Gly His 
    370                 375                 380             


<210>  252
<211>  128
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD59  <Accession No.: CAG46523.1>

<400>  252

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  253
<211>  114
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NOTCH REGULATED ANKYRIN REPEAT PROTEIN (NRARP) <Accession 
No.: NP_001004354.1>

<400>  253

Met Ser Gln Ala Glu Leu Ser Thr Cys Ser Ala Pro Gln Thr Gln Arg 
1               5                   10                  15      


Ile Phe Gln Glu Ala Val Arg Lys Gly Asn Thr Gln Glu Leu Gln Ser 
            20                  25                  30          


Leu Leu Gln Asn Met Thr Asn Cys Glu Phe Asn Val Asn Ser Phe Gly 
        35                  40                  45              


Pro Glu Gly Gln Thr Ala Leu His Gln Ser Val Ile Asp Gly Asn Leu 
    50                  55                  60                  


Glu Leu Val Lys Leu Leu Val Lys Phe Gly Ala Asp Ile Arg Leu Ala 
65                  70                  75                  80  


Asn Arg Asp Gly Trp Ser Ala Leu His Ile Ala Ala Phe Gly Gly His 
                85                  90                  95      


Gln Asp Ile Val Leu Tyr Leu Ile Thr Lys Ala Lys Tyr Ala Ala Ser 
            100                 105                 110         


Gly Arg 
        


<210>  254
<211>  491
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ALPHA-2-ANTIPLASMIN (A2AP), ISOFORM A PRECURSOR 
<Accession No.: NP_000925.2>

<400>  254

Met Ala Leu Leu Trp Gly Leu Leu Val Leu Ser Trp Ser Cys Leu Gln 
1               5                   10                  15      


Gly Pro Cys Ser Val Phe Ser Pro Val Ser Ala Met Glu Pro Leu Gly 
            20                  25                  30          


Arg Gln Leu Thr Ser Gly Pro Asn Gln Glu Gln Val Ser Pro Leu Thr 
        35                  40                  45              


Leu Leu Lys Leu Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys 
    50                  55                  60                  


Ser Pro Pro Gly Val Cys Ser Arg Asp Pro Thr Pro Glu Gln Thr His 
65                  70                  75                  80  


Arg Leu Ala Arg Ala Met Met Ala Phe Thr Ala Asp Leu Phe Ser Leu 
                85                  90                  95      


Val Ala Gln Thr Ser Thr Cys Pro Asn Leu Ile Leu Ser Pro Leu Ser 
            100                 105                 110         


Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala Gln Asn His Thr 
        115                 120                 125             


Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly Ser Gly Pro Cys Leu 
    130                 135                 140                 


Pro His Leu Leu Ser Arg Leu Cys Gln Asp Leu Gly Pro Gly Ala Phe 
145                 150                 155                 160 


Arg Leu Ala Ala Arg Met Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu 
                165                 170                 175     


Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser 
            180                 185                 190         


Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val 
        195                 200                 205             


Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro 
    210                 215                 220                 


Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly Phe 
225                 230                 235                 240 


Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg Asp Ser Phe His 
                245                 250                 255     


Leu Asp Glu Gln Phe Thr Val Pro Val Glu Met Met Gln Ala Arg Thr 
            260                 265                 270         


Tyr Pro Leu Arg Trp Phe Leu Leu Glu Gln Pro Glu Ile Gln Val Ala 
        275                 280                 285             


His Phe Pro Phe Lys Asn Asn Met Ser Phe Val Val Leu Val Pro Thr 
    290                 295                 300                 


His Phe Glu Trp Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp 
305                 310                 315                 320 


Thr Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu 
                325                 330                 335     


Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser 
            340                 345                 350         


Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg Gly Ile 
        355                 360                 365             


Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His Gln Ser Thr Leu 
    370                 375                 380                 


Glu Leu Ser Glu Val Gly Val Glu Ala Ala Ala Ala Thr Ser Ile Ala 
385                 390                 395                 400 


Met Ser Arg Met Ser Leu Ser Ser Phe Ser Val Asn Arg Pro Phe Leu 
                405                 410                 415     


Phe Phe Ile Phe Glu Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser 
            420                 425                 430         


Val Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln 
        435                 440                 445             


Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro 
    450                 455                 460                 


Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met 
465                 470                 475                 480 


Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 
                485                 490     


<210>  255
<211>  427
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ALPHA-2-ANTIPLASMIN (A2AP), ISOFORM B PRECURSOR 
<Accession No.: NP_001159393.1>

<400>  255

Met Ala Leu Leu Trp Gly Leu Leu Val Leu Ser Trp Ser Cys Leu Gln 
1               5                   10                  15      


Gly Pro Cys Ser Val Phe Ser Pro Val Ser Ala Met Glu Pro Leu Gly 
            20                  25                  30          


Arg Gln Leu Thr Ser Gly Pro Asn Gln Glu Gln Val Ser Pro Leu Thr 
        35                  40                  45              


Leu Leu Lys Leu Gly Asn Gln Val Gln Pro Gly Ala Gln Asn His Thr 
    50                  55                  60                  


Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly Ser Gly Pro Cys Leu 
65                  70                  75                  80  


Pro His Leu Leu Ser Arg Leu Cys Gln Asp Leu Gly Pro Gly Ala Phe 
                85                  90                  95      


Arg Leu Ala Ala Arg Met Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu 
            100                 105                 110         


Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser 
        115                 120                 125             


Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val 
    130                 135                 140                 


Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro 
145                 150                 155                 160 


Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly Phe 
                165                 170                 175     


Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg Asp Ser Phe His 
            180                 185                 190         


Leu Asp Glu Gln Phe Thr Val Pro Val Glu Met Met Gln Ala Arg Thr 
        195                 200                 205             


Tyr Pro Leu Arg Trp Phe Leu Leu Glu Gln Pro Glu Ile Gln Val Ala 
    210                 215                 220                 


His Phe Pro Phe Lys Asn Asn Met Ser Phe Val Val Leu Val Pro Thr 
225                 230                 235                 240 


His Phe Glu Trp Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp 
                245                 250                 255     


Thr Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu 
            260                 265                 270         


Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser 
        275                 280                 285             


Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg Gly Ile 
    290                 295                 300                 


Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His Gln Ser Thr Leu 
305                 310                 315                 320 


Glu Leu Ser Glu Val Gly Val Glu Ala Ala Ala Ala Thr Ser Ile Ala 
                325                 330                 335     


Met Ser Arg Met Ser Leu Ser Ser Phe Ser Val Asn Arg Pro Phe Leu 
            340                 345                 350         


Phe Phe Ile Phe Glu Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser 
        355                 360                 365             


Val Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln 
    370                 375                 380                 


Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro 
385                 390                 395                 400 


Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met 
                405                 410                 415     


Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 
            420                 425         


<210>  256
<211>  810
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PLASMINOGEN (PLG) <Accession No.: AAA60113.1>

<400>  256

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Leu Leu Pro Asn Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  257
<211>  217
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GROWTH HORMONE <Accession No.: AAA98618.1>

<400>  257

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  258
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INSULIN LIKE GROWTH FACTOR 1 (IGF1) <Accession No.: 
CAG46659.1>

<400>  258

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  259
<211>  269
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTERLEUKIN 1 BETA (IL1B) <Accession No.: AAA74137.1>

<400>  259

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  260
<211>  805
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ANGIOTENSIN I CONVERTING ENZYME 2 (ACE2) 
 <Accession No.: ACT66268.1>

<400>  260

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  261
<211>  1163
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTEGRIN ALPHA SUBUNIT PRECURSOR  <Accession No.: AAA51620.1>

<400>  261

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Leu Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Thr Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Thr Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Thr Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Thr Gln Leu Arg Glu Lys Ile Phe Pro Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Pro Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Pro 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Ala Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser Leu Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Gly  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


<210>  262
<211>  798
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTEGRIN ALPHA SUBUNIT PRECURSOR  <Accession No.: P05556.2>

<400>  262

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  263
<211>  151
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD40  <Accession No.: AAH64518.1>

<400>  263

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Phe His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Asp Ile Cys Gln Pro His Phe Pro Lys Asp 
    130                 135                 140                 


Arg Gly Leu Asn Leu Leu Met 
145                 150     


<210>  264
<211>  1366
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)  
<Accession No.: AAI43722.1>

<400>  264

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Arg 
        915                 920                 925             


Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val Leu 
    930                 935                 940                 


Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg Lys 
945                 950                 955                 960 


Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val Asn 
                965                 970                 975     


Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp Glu 
            980                 985                 990         


Val Ala Arg Glu Lys Ile Thr Met  Ser Arg Glu Leu Gly  Gln Gly Ser 
        995                 1000                 1005             


Phe Gly  Met Val Tyr Glu Gly  Val Ala Lys Gly Val  Val Lys Asp 
    1010                 1015                 1020             


Glu Pro  Glu Thr Arg Val Ala  Ile Lys Thr Val Asn  Glu Ala Ala 
    1025                 1030                 1035             


Ser Met  Arg Glu Arg Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met 
    1040                 1045                 1050             


Lys Glu  Phe Asn Cys His His  Val Val Arg Leu Leu  Gly Val Val 
    1055                 1060                 1065             


Ser Gln  Gly Gln Pro Thr Leu  Val Ile Met Glu Leu  Met Thr Arg 
    1070                 1075                 1080             


Gly Asp  Leu Lys Ser Tyr Leu  Arg Ser Leu Arg Pro  Glu Met Glu 
    1085                 1090                 1095             


Asn Asn  Pro Val Leu Ala Pro  Pro Ser Leu Ser Lys  Met Ile Gln 
    1100                 1105                 1110             


Met Ala  Gly Glu Ile Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Asn 
    1115                 1120                 1125             


Lys Phe  Val His Arg Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala 
    1130                 1135                 1140             


Glu Asp  Phe Thr Val Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp 
    1145                 1150                 1155             


Ile Tyr  Glu Thr Asp Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu 
    1160                 1165                 1170             


Pro Val  Arg Trp Met Ser Pro  Glu Ser Leu Lys Asp  Gly Val Phe 
    1175                 1180                 1185             


Thr Thr  Tyr Ser Asp Val Trp  Ser Phe Gly Val Val  Leu Trp Glu 
    1190                 1195                 1200             


Ile Ala  Thr Leu Ala Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu 
    1205                 1210                 1215             


Gln Val  Leu Arg Phe Val Met  Glu Gly Gly Leu Leu  Asp Lys Pro 
    1220                 1225                 1230             


Asp Asn  Cys Pro Asp Met Leu  Phe Glu Leu Met Arg  Met Cys Trp 
    1235                 1240                 1245             


Gln Tyr  Asn Pro Lys Met Arg  Pro Ser Phe Leu Glu  Ile Ile Ser 
    1250                 1255                 1260             


Ser Ile  Lys Glu Glu Met Glu  Pro Gly Phe Arg Glu  Val Ser Phe 
    1265                 1270                 1275             


Tyr Tyr  Ser Glu Glu Asn Lys  Leu Pro Glu Pro Glu  Glu Leu Asp 
    1280                 1285                 1290             


Leu Glu  Pro Glu Asn Met Glu  Ser Val Pro Leu Asp  Pro Ser Ala 
    1295                 1300                 1305             


Ser Ser  Ser Ser Leu Pro Leu  Pro Asp Arg His Ser  Gly His Lys 
    1310                 1315                 1320             


Ala Glu  Asn Gly Pro Gly Pro  Gly Val Leu Val Leu  Arg Ala Ser 
    1325                 1330                 1335             


Phe Asp  Glu Arg Gln Pro Tyr  Ala His Met Asn Gly  Gly Arg Lys 
    1340                 1345                 1350             


Asn Glu  Arg Ala Leu Pro Leu  Pro Gln Ser Ser Thr  Cys 
    1355                 1360                 1365     


<210>  265
<211>  2491
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INSULIN-LIKE GROWTH FACTOR 2 RECEPTOR (IGF2R)  
<Accession No.: AAK56918.1>

<400>  265

Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 
                485                 490                 495     


Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 
            500                 505                 510         


His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 
        515                 520                 525             


Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 
    530                 535                 540                 


Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 
545                 550                 555                 560 


Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 
                565                 570                 575     


Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 
            580                 585                 590         


Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 
        595                 600                 605             


Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 
    610                 615                 620                 


Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 
625                 630                 635                 640 


Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 
                645                 650                 655     


Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 
            660                 665                 670         


Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr 
        675                 680                 685             


Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met 
    690                 695                 700                 


Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His 
705                 710                 715                 720 


Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly 
                725                 730                 735     


Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe 
            740                 745                 750         


Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val 
        755                 760                 765             


Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala 
    770                 775                 780                 


Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser 
785                 790                 795                 800 


Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro 
                805                 810                 815     


Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met 
            820                 825                 830         


Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser 
        835                 840                 845             


Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser 
    850                 855                 860                 


Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly 
865                 870                 875                 880 


Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly 
                885                 890                 895     


Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val 
            900                 905                 910         


Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr 
        915                 920                 925             


Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val 
    930                 935                 940                 


Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly 
945                 950                 955                 960 


Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys 
                965                 970                 975     


Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln 
            980                 985                 990         


Thr Glu Glu Leu Lys Asn Trp Lys  Pro Ala Arg Pro Val  Gly Ile Glu 
        995                 1000                 1005             


Lys Ser  Leu Gln Leu Ser Thr  Glu Gly Phe Ile Thr  Leu Thr Tyr 
    1010                 1015                 1020             


Lys Gly  Pro Leu Ser Ala Lys  Gly Thr Ala Asp Ala  Phe Ile Val 
    1025                 1030                 1035             


Arg Phe  Val Cys Asn Asp Asp  Val Tyr Ser Gly Pro  Leu Lys Phe 
    1040                 1045                 1050             


Leu His  Gln Asp Ile Asp Ser  Gly Gln Gly Ile Arg  Asn Thr Tyr 
    1055                 1060                 1065             


Phe Glu  Phe Glu Thr Ala Leu  Ala Cys Val Pro Ser  Pro Val Asp 
    1070                 1075                 1080             


Cys Gln  Val Thr Asp Leu Ala  Gly Asn Glu Tyr Asp  Leu Thr Gly 
    1085                 1090                 1095             


Leu Ser  Thr Val Arg Lys Pro  Trp Thr Ala Val Asp  Thr Ser Val 
    1100                 1105                 1110             


Asp Gly  Arg Lys Arg Thr Phe  Tyr Leu Ser Val Cys  Asn Pro Leu 
    1115                 1120                 1125             


Pro Tyr  Ile Pro Gly Cys Gln  Gly Ser Ala Val Gly  Ser Cys Leu 
    1130                 1135                 1140             


Val Ser  Glu Gly Asn Ser Trp  Asn Leu Gly Val Val  Gln Met Ser 
    1145                 1150                 1155             


Pro Gln  Ala Ala Ala Asn Gly  Ser Leu Ser Ile Met  Tyr Val Asn 
    1160                 1165                 1170             


Gly Asp  Lys Cys Gly Asn Gln  Arg Phe Ser Thr Arg  Ile Thr Phe 
    1175                 1180                 1185             


Glu Cys  Ala Gln Ile Ser Gly  Ser Pro Ala Phe Gln  Leu Gln Asp 
    1190                 1195                 1200             


Gly Cys  Glu Tyr Val Phe Ile  Trp Arg Thr Val Glu  Ala Cys Pro 
    1205                 1210                 1215             


Val Val  Arg Val Glu Gly Asp  Asn Cys Glu Val Lys  Asp Pro Arg 
    1220                 1225                 1230             


His Gly  Asn Leu Tyr Asp Leu  Lys Pro Leu Gly Leu  Asn Asp Thr 
    1235                 1240                 1245             


Ile Val  Ser Ala Gly Glu Tyr  Thr Tyr Tyr Phe Arg  Val Cys Gly 
    1250                 1255                 1260             


Lys Leu  Ser Ser Asp Val Cys  Pro Thr Ser Asp Lys  Ser Lys Val 
    1265                 1270                 1275             


Val Ser  Ser Cys Gln Glu Lys  Arg Glu Pro Gln Gly  Phe His Lys 
    1280                 1285                 1290             


Val Ala  Gly Leu Leu Thr Gln  Lys Leu Thr Tyr Glu  Asn Gly Leu 
    1295                 1300                 1305             


Leu Lys  Met Asn Phe Thr Gly  Gly Asp Thr Cys His  Lys Val Tyr 
    1310                 1315                 1320             


Gln Arg  Ser Thr Ala Ile Phe  Phe Tyr Cys Asp Arg  Gly Thr Gln 
    1325                 1330                 1335             


Arg Pro  Val Phe Leu Lys Glu  Thr Ser Asp Cys Ser  Tyr Leu Phe 
    1340                 1345                 1350             


Glu Trp  Arg Thr Gln Tyr Ala  Cys Pro Pro Phe Asp  Leu Thr Glu 
    1355                 1360                 1365             


Cys Ser  Phe Lys Asp Gly Ala  Gly Asn Ser Phe Asp  Leu Ser Ser 
    1370                 1375                 1380             


Leu Ser  Arg Tyr Ser Asp Asn  Trp Glu Ala Ile Thr  Gly Thr Gly 
    1385                 1390                 1395             


Asp Pro  Glu His Tyr Leu Ile  Asn Val Cys Lys Ser  Leu Ala Pro 
    1400                 1405                 1410             


Gln Ala  Gly Thr Glu Pro Cys  Pro Pro Glu Ala Ala  Ala Cys Leu 
    1415                 1420                 1425             


Leu Gly  Gly Ser Lys Pro Val  Asn Leu Gly Arg Val  Arg Asp Gly 
    1430                 1435                 1440             


Pro Gln  Trp Arg Asp Gly Ile  Ile Val Leu Lys Tyr  Val Asp Gly 
    1445                 1450                 1455             


Asp Leu  Cys Pro Asp Gly Ile  Arg Lys Lys Ser Thr  Thr Ile Arg 
    1460                 1465                 1470             


Phe Thr  Cys Ser Glu Ser Gln  Val Asn Ser Arg Pro  Met Phe Ile 
    1475                 1480                 1485             


Ser Ala  Val Glu Asp Cys Glu  Tyr Thr Phe Ala Trp  Pro Thr Ala 
    1490                 1495                 1500             


Thr Ala  Cys Pro Met Lys Ser  Asn Glu His Asp Asp  Cys Gln Val 
    1505                 1510                 1515             


Thr Asn  Pro Ser Thr Gly His  Leu Phe Asp Leu Ser  Ser Leu Ser 
    1520                 1525                 1530             


Gly Arg  Ala Gly Phe Thr Ala  Ala Tyr Ser Glu Lys  Gly Leu Val 
    1535                 1540                 1545             


Tyr Met  Ser Ile Cys Gly Glu  Asn Glu Asn Cys Pro  Pro Gly Val 
    1550                 1555                 1560             


Gly Ala  Cys Phe Gly Gln Thr  Arg Ile Ser Val Gly  Lys Ala Asn 
    1565                 1570                 1575             


Lys Arg  Leu Arg Tyr Val Asp  Gln Val Leu Gln Leu  Val Tyr Lys 
    1580                 1585                 1590             


Asp Gly  Ser Pro Cys Pro Ser  Lys Ser Gly Leu Ser  Tyr Lys Ser 
    1595                 1600                 1605             


Val Ile  Ser Phe Val Cys Arg  Pro Glu Ala Arg Pro  Thr Asn Arg 
    1610                 1615                 1620             


Pro Met  Leu Ile Ser Leu Asp  Lys Gln Thr Cys Thr  Leu Phe Phe 
    1625                 1630                 1635             


Ser Trp  His Thr Pro Leu Ala  Cys Glu Gln Ala Thr  Glu Cys Ser 
    1640                 1645                 1650             


Val Arg  Asn Gly Ser Ser Ile  Val Asp Leu Ser Pro  Leu Ile His 
    1655                 1660                 1665             


Arg Thr  Gly Gly Tyr Glu Ala  Tyr Asp Glu Ser Glu  Asp Asp Ala 
    1670                 1675                 1680             


Ser Asp  Thr Asn Pro Asp Phe  Tyr Ile Asn Ile Cys  Gln Pro Leu 
    1685                 1690                 1695             


Asn Pro  Met His Gly Val Pro  Cys Pro Ala Gly Ala  Ala Val Cys 
    1700                 1705                 1710             


Lys Val  Pro Ile Asp Gly Pro  Pro Ile Asp Ile Gly  Arg Val Ala 
    1715                 1720                 1725             


Gly Pro  Pro Ile Leu Asn Pro  Ile Ala Asn Glu Ile  Tyr Leu Asn 
    1730                 1735                 1740             


Phe Glu  Ser Ser Thr Pro Cys  Leu Ala Asp Lys His  Phe Asn Tyr 
    1745                 1750                 1755             


Thr Ser  Leu Ile Ala Phe His  Cys Lys Arg Gly Val  Ser Met Gly 
    1760                 1765                 1770             


Thr Pro  Lys Leu Leu Arg Thr  Ser Glu Cys Asp Phe  Val Phe Glu 
    1775                 1780                 1785             


Trp Glu  Thr Pro Val Val Cys  Pro Asp Glu Val Arg  Met Asp Gly 
    1790                 1795                 1800             


Cys Thr  Leu Thr Asp Glu Gln  Leu Leu Tyr Ser Phe  Asn Leu Ser 
    1805                 1810                 1815             


Ser Leu  Ser Thr Ser Thr Phe  Lys Val Thr Arg Asp  Ser Arg Thr 
    1820                 1825                 1830             


Tyr Ser  Val Gly Val Cys Thr  Phe Ala Val Gly Pro  Glu Gln Gly 
    1835                 1840                 1845             


Gly Cys  Lys Asp Gly Gly Val  Cys Leu Leu Ser Gly  Thr Lys Gly 
    1850                 1855                 1860             


Ala Ser  Phe Gly Arg Leu Gln  Ser Met Lys Leu Asp  Tyr Arg His 
    1865                 1870                 1875             


Gln Asp  Glu Ala Val Val Leu  Ser Tyr Val Asn Gly  Asp Arg Cys 
    1880                 1885                 1890             


Pro Pro  Glu Thr Asp Asp Gly  Val Pro Cys Val Phe  Pro Phe Ile 
    1895                 1900                 1905             


Phe Asn  Gly Lys Ser Tyr Glu  Glu Cys Ile Ile Glu  Ser Arg Ala 
    1910                 1915                 1920             


Lys Leu  Trp Cys Ser Thr Thr  Ala Asp Tyr Asp Arg  Asp His Glu 
    1925                 1930                 1935             


Trp Gly  Phe Cys Arg His Ser  Asn Ser Tyr Arg Thr  Ser Ser Ile 
    1940                 1945                 1950             


Ile Phe  Lys Cys Asp Glu Asp  Glu Asp Ile Gly Arg  Pro Gln Val 
    1955                 1960                 1965             


Phe Ser  Glu Val Arg Gly Cys  Asp Val Thr Phe Glu  Trp Lys Thr 
    1970                 1975                 1980             


Lys Val  Val Cys Pro Pro Lys  Lys Leu Glu Cys Lys  Phe Val Gln 
    1985                 1990                 1995             


Lys His  Lys Thr Tyr Asp Leu  Arg Leu Leu Ser Ser  Leu Thr Gly 
    2000                 2005                 2010             


Ser Trp  Ser Leu Val His Asn  Gly Val Ser Tyr Tyr  Ile Asn Leu 
    2015                 2020                 2025             


Cys Gln  Lys Ile Tyr Lys Gly  Pro Leu Gly Cys Ser  Glu Arg Ala 
    2030                 2035                 2040             


Ser Ile  Cys Arg Arg Thr Thr  Thr Gly Asp Val Gln  Val Leu Gly 
    2045                 2050                 2055             


Leu Val  His Thr Gln Lys Leu  Gly Val Ile Gly Asp  Lys Val Val 
    2060                 2065                 2070             


Val Thr  Tyr Ser Lys Gly Tyr  Pro Cys Gly Gly Asn  Lys Thr Ala 
    2075                 2080                 2085             


Ser Ser  Val Ile Glu Leu Thr  Cys Thr Lys Thr Val  Gly Arg Pro 
    2090                 2095                 2100             


Ala Phe  Lys Arg Phe Asp Ile  Asp Ser Cys Thr Tyr  Tyr Phe Ser 
    2105                 2110                 2115             


Trp Asp  Ser Arg Ala Ala Cys  Ala Val Lys Pro Gln  Glu Val Gln 
    2120                 2125                 2130             


Met Val  Asn Gly Thr Ile Thr  Asn Pro Ile Asn Gly  Lys Ser Phe 
    2135                 2140                 2145             


Ser Leu  Gly Asp Ile Tyr Phe  Lys Leu Phe Arg Ala  Ser Gly Asp 
    2150                 2155                 2160             


Met Arg  Thr Asn Gly Asp Asn  Tyr Leu Tyr Glu Ile  Gln Leu Ser 
    2165                 2170                 2175             


Ser Ile  Thr Ser Ser Arg Asn  Pro Ala Cys Ser Gly  Ala Asn Ile 
    2180                 2185                 2190             


Cys Gln  Val Lys Pro Asn Asp  Gln His Phe Ser Arg  Lys Val Gly 
    2195                 2200                 2205             


Thr Ser  Asp Lys Thr Lys Tyr  Tyr Leu Gln Asp Gly  Asp Leu Asp 
    2210                 2215                 2220             


Val Val  Phe Ala Ser Ser Ser  Lys Cys Gly Lys Asp  Lys Thr Lys 
    2225                 2230                 2235             


Ser Val  Ser Ser Thr Ile Phe  Phe His Cys Asp Pro  Leu Val Glu 
    2240                 2245                 2250             


Asp Gly  Ile Pro Glu Phe Ser  His Glu Thr Ala Asp  Cys Gln Tyr 
    2255                 2260                 2265             


Leu Phe  Ser Trp Tyr Thr Ser  Ala Val Cys Pro Leu  Gly Val Gly 
    2270                 2275                 2280             


Phe Asp  Ser Glu Asn Pro Gly  Asp Asp Gly Gln Met  His Lys Gly 
    2285                 2290                 2295             


Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala Val Leu  Ser Leu Leu 
    2300                 2305                 2310             


Leu Val  Ala Leu Thr Cys Cys  Leu Leu Ala Leu Leu  Leu Tyr Lys 
    2315                 2320                 2325             


Lys Glu  Arg Arg Glu Thr Val  Ile Ser Lys Leu Thr  Thr Cys Cys 
    2330                 2335                 2340             


Arg Arg  Ser Ser Asn Val Ser  Tyr Lys Tyr Ser Lys  Val Asn Lys 
    2345                 2350                 2355             


Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu Trp Leu  Met Glu Glu 
    2360                 2365                 2370             


Ile Gln  Leu Pro Pro Pro Arg  Gln Gly Lys Glu Gly  Gln Glu Asn 
    2375                 2380                 2385             


Gly His  Ile Thr Thr Lys Ser  Val Lys Ala Leu Ser  Ser Leu His 
    2390                 2395                 2400             


Gly Asp  Asp Gln Asp Ser Glu  Asp Glu Val Leu Thr  Ile Pro Glu 
    2405                 2410                 2415             


Val Lys  Val His Ser Gly Arg  Gly Ala Gly Ala Glu  Ser Ser His 
    2420                 2425                 2430             


Pro Val  Arg Asn Ala Gln Ser  Asn Ala Leu Gln Glu  Arg Glu Asp 
    2435                 2440                 2445             


Asp Arg  Val Gly Leu Val Arg  Gly Glu Lys Ala Arg  Lys Gly Lys 
    2450                 2455                 2460             


Ser Ser  Ser Ala Gln Gln Lys  Thr Val Ser Ser Thr  Lys Leu Val 
    2465                 2470                 2475             


Ser Phe  His Asp Asp Ser Asp  Glu Asp Leu Leu His  Ile 
    2480                 2485                 2490     


<210>  266
<211>  232
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RTP801  <Accession No.: AAL38424.1>

<400>  266

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  267
<211>  457
<212>  PRT
<213>  Homo sapiens

<220>
<223>  METALLOPROTEINASE 2 (MMP2)  <Accession No.: BAA12023>

<400>  267

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Val Lys Gly Asp Thr Leu Ser Val Ile 
                405                 410                 415     


Gln Asp Gly Trp Leu Tyr Lys Tyr His Trp Lys Trp Ile Leu Glu Gln 
            420                 425                 430         


Arg Gln Ser Val Pro Val Leu Ser Arg Gln Thr Glu Lys His Lys Thr 
        435                 440                 445             


Tyr Glu Glu Leu Ser Ser Ile Thr Tyr 
    450                 455         


<210>  268
<211>  404
<212>  PRT
<213>  Homo sapiens

<220>
<223>  G-PROTEIN COUPLED RECEPTOR 143 (GPR143) <Accession No.: NP_000264>

<400>  268

Met Ala Ser Pro Arg Leu Gly Thr Phe Cys Cys Pro Thr Arg Asp Ala 
1               5                   10                  15      


Ala Thr Gln Leu Val Leu Ser Phe Gln Pro Arg Ala Phe His Ala Leu 
            20                  25                  30          


Cys Leu Gly Ser Gly Gly Leu Arg Leu Ala Leu Gly Leu Leu Gln Leu 
        35                  40                  45              


Leu Pro Gly Arg Arg Pro Ala Gly Pro Gly Ser Pro Ala Thr Ser Pro 
    50                  55                  60                  


Pro Ala Ser Val Arg Ile Leu Arg Ala Ala Ala Ala Cys Asp Leu Leu 
65                  70                  75                  80  


Gly Cys Leu Gly Met Val Ile Arg Ser Thr Val Trp Leu Gly Phe Pro 
                85                  90                  95      


Asn Phe Val Asp Ser Val Ser Asp Met Asn His Thr Glu Ile Trp Pro 
            100                 105                 110         


Ala Ala Phe Cys Val Gly Ser Ala Met Trp Ile Gln Leu Leu Tyr Ser 
        115                 120                 125             


Ala Cys Phe Trp Trp Leu Phe Cys Tyr Ala Val Asp Ala Tyr Leu Val 
    130                 135                 140                 


Ile Arg Arg Ser Ala Gly Leu Ser Thr Ile Leu Leu Tyr His Ile Met 
145                 150                 155                 160 


Ala Trp Gly Leu Ala Thr Leu Leu Cys Val Glu Gly Ala Ala Met Leu 
                165                 170                 175     


Tyr Tyr Pro Ser Val Ser Arg Cys Glu Arg Gly Leu Asp His Ala Ile 
            180                 185                 190         


Pro His Tyr Val Thr Met Tyr Leu Pro Leu Leu Leu Val Leu Val Ala 
        195                 200                 205             


Asn Pro Ile Leu Phe Gln Lys Thr Val Thr Ala Val Ala Ser Leu Leu 
    210                 215                 220                 


Lys Gly Arg Gln Gly Ile Tyr Thr Glu Asn Glu Arg Arg Met Gly Ala 
225                 230                 235                 240 


Val Ile Lys Ile Arg Phe Phe Lys Ile Met Leu Val Leu Ile Ile Cys 
                245                 250                 255     


Trp Leu Ser Asn Ile Ile Asn Glu Ser Leu Leu Phe Tyr Leu Glu Met 
            260                 265                 270         


Gln Thr Asp Ile Asn Gly Gly Ser Leu Lys Pro Val Arg Thr Ala Ala 
        275                 280                 285             


Lys Thr Thr Trp Phe Ile Met Gly Ile Leu Asn Pro Ala Gln Gly Phe 
    290                 295                 300                 


Leu Leu Ser Leu Ala Phe Tyr Gly Trp Thr Gly Cys Ser Leu Gly Phe 
305                 310                 315                 320 


Gln Ser Pro Arg Lys Glu Ile Gln Trp Glu Ser Leu Thr Thr Ser Ala 
                325                 330                 335     


Ala Glu Gly Ala His Pro Ser Pro Leu Met Pro His Glu Asn Pro Ala 
            340                 345                 350         


Ser Gly Lys Val Ser Gln Val Gly Gly Gln Thr Ser Asp Glu Ala Leu 
        355                 360                 365             


Ser Met Leu Ser Glu Gly Ser Asp Ala Ser Thr Ile Glu Ile His Thr 
    370                 375                 380                 


Ala Ser Glu Ser Cys Asn Lys Asn Glu Gly Asp Pro Ala Leu Pro Thr 
385                 390                 395                 400 


His Gly Asp Leu 
                


<210>  269
<211>  424
<212>  PRT
<213>  Homo sapiens

<220>
<223>  G-PROTEIN COUPLED RECEPTOR 143 (GPR143) <Accession No.:
 EAW98773.1>

<400>  269

Met Thr Gln Ala Gly Arg Arg Gly Pro Gly Thr Pro Glu Pro Arg Pro 
1               5                   10                  15      


Arg Thr Gln Pro Met Ala Ser Pro Arg Leu Gly Thr Phe Cys Cys Pro 
            20                  25                  30          


Thr Arg Asp Ala Ala Thr Gln Leu Val Leu Ser Phe Gln Pro Arg Ala 
        35                  40                  45              


Phe His Ala Leu Cys Leu Gly Ser Gly Gly Leu Arg Leu Ala Leu Gly 
    50                  55                  60                  


Leu Leu Gln Leu Leu Pro Gly Arg Arg Pro Ala Gly Pro Gly Ser Pro 
65                  70                  75                  80  


Ala Thr Ser Pro Pro Ala Ser Val Arg Ile Leu Arg Ala Ala Ala Ala 
                85                  90                  95      


Cys Asp Leu Leu Gly Cys Leu Gly Met Val Ile Arg Ser Thr Val Trp 
            100                 105                 110         


Leu Gly Phe Pro Asn Phe Val Asp Ser Val Ser Asp Met Asn His Thr 
        115                 120                 125             


Glu Ile Trp Pro Ala Ala Phe Cys Val Gly Ser Ala Met Trp Ile Gln 
    130                 135                 140                 


Leu Leu Tyr Ser Ala Cys Phe Trp Trp Leu Phe Cys Tyr Ala Val Asp 
145                 150                 155                 160 


Ala Tyr Leu Val Ile Arg Arg Ser Ala Gly Leu Ser Thr Ile Leu Leu 
                165                 170                 175     


Tyr His Ile Met Ala Trp Gly Leu Ala Thr Leu Leu Cys Val Glu Gly 
            180                 185                 190         


Ala Ala Met Leu Tyr Tyr Pro Ser Val Ser Arg Cys Glu Arg Gly Leu 
        195                 200                 205             


Asp His Ala Ile Pro His Tyr Val Thr Met Tyr Leu Pro Leu Leu Leu 
    210                 215                 220                 


Val Leu Val Ala Asn Pro Ile Leu Phe Gln Lys Thr Val Thr Ala Val 
225                 230                 235                 240 


Ala Ser Leu Leu Lys Gly Arg Gln Gly Ile Tyr Thr Glu Asn Glu Arg 
                245                 250                 255     


Arg Met Gly Ala Val Ile Lys Ile Arg Phe Phe Lys Ile Met Leu Val 
            260                 265                 270         


Leu Ile Ile Cys Trp Leu Ser Asn Ile Ile Asn Glu Ser Leu Leu Phe 
        275                 280                 285             


Tyr Leu Glu Met Gln Thr Asp Ile Asn Gly Gly Ser Leu Lys Pro Val 
    290                 295                 300                 


Arg Thr Ala Ala Lys Thr Thr Trp Phe Ile Met Gly Ile Leu Asn Pro 
305                 310                 315                 320 


Ala Gln Gly Phe Leu Leu Ser Leu Ala Phe Tyr Gly Trp Thr Gly Cys 
                325                 330                 335     


Ser Leu Gly Phe Gln Ser Pro Arg Lys Glu Ile Gln Trp Glu Ser Leu 
            340                 345                 350         


Thr Thr Ser Ala Ala Glu Gly Ala His Pro Ser Pro Leu Met Pro His 
        355                 360                 365             


Glu Asn Pro Ala Ser Gly Lys Val Ser Gln Val Gly Gly Gln Thr Ser 
    370                 375                 380                 


Asp Glu Ala Leu Ser Met Leu Ser Glu Gly Ser Asp Ala Ser Thr Ile 
385                 390                 395                 400 


Glu Ile His Thr Ala Ser Glu Ser Cys Asn Lys Asn Glu Gly Asp Pro 
                405                 410                 415     


Ala Leu Pro Thr His Gly Asp Leu 
            420                 


<210>  270
<211>  529
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TYROSINASE (TYR) <Accession No.: AAB60319.1>

<400>  270

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Gln Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  271
<211>  312
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CASPASE 2 (CASP2) <Accession No.: CAG46548.1>

<400>  271

Met His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu 
1               5                   10                  15      


Ala Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys 
            20                  25                  30          


Asp Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly 
        35                  40                  45              


Ser Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly 
    50                  55                  60                  


Pro Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln 
65                  70                  75                  80  


Gly His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His 
                85                  90                  95      


Val Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro 
            100                 105                 110         


Val Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp 
        115                 120                 125             


Thr Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln 
    130                 135                 140                 


Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala 
145                 150                 155                 160 


Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn 
                165                 170                 175     


Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp 
            180                 185                 190         


Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp 
        195                 200                 205             


Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu 
    210                 215                 220                 


Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile 
225                 230                 235                 240 


Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp 
                245                 250                 255     


Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala 
            260                 265                 270         


Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala 
        275                 280                 285             


Cys Arg Gly Gly Ala Ile Gly Ser Leu Gly His Leu Leu Leu Phe Thr 
    290                 295                 300                 


Ala Ala Thr Ala Ser Leu Ala Leu 
305                 310         


<210>  272
<211>  614
<212>  PRT
<213>  Homo sapiens

<220>
<223>  LEUCINE RICH REPEAT AND IG DOMAIN CONTAINING PROTEIN 1 (LINGO1)
 <Accession No.: AAH68558.1>

<400>  272

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Tyr Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Arg Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Arg Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  273
<211>  306
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1) <Accession No.:
 AAH08426.1>

<400>  273

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  274
<211>  563
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRIPEPTIDYL-PEPTIDASE 1 (TPP1) <Accession No.: NP_000382.3>

<400>  274

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  275
<211>  360
<212>  PRT
<213>  Homo sapiens

<220>
<223>  BATTENIN (CLN3) <Accession No.: AAI11069.1>

<400>  275

Met Leu Ser Ala Ala His Asp Ile Leu Ser His Lys Arg Thr Ser Gly 
1               5                   10                  15      


Asn Gln Ser His Ala Val Leu Leu Ala Asp Ile Leu Pro Thr Leu Val 
            20                  25                  30          


Ile Lys Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro 
        35                  40                  45              


Arg Val Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val 
    50                  55                  60                  


Ala Phe Ser His Ser Val Gly Thr Ser Leu Cys Gly Val Val Phe Ala 
65                  70                  75                  80  


Ser Ile Ser Ser Gly Leu Gly Glu Val Thr Phe Leu Ser Leu Thr Ala 
                85                  90                  95      


Phe Tyr Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Thr Gly Gly 
            100                 105                 110         


Ala Gly Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Thr Gln Ala Gly 
        115                 120                 125             


Leu Ser Pro Gln Gln Thr Leu Leu Ser Met Leu Gly Ile Pro Ala Leu 
    130                 135                 140                 


Leu Leu Ala Ser Tyr Phe Leu Leu Leu Thr Ser Pro Glu Ala Gln Asp 
145                 150                 155                 160 


Pro Gly Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile 
                165                 170                 175     


Arg Thr Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser 
            180                 185                 190         


Leu Arg Glu Arg Trp Thr Val Phe Lys Gly Leu Leu Trp Tyr Ile Val 
        195                 200                 205             


Pro Leu Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu 
    210                 215                 220                 


Phe Glu Leu Leu Phe Phe Trp Asn Thr Ser Leu Ser His Ala Gln Gln 
225                 230                 235                 240 


Tyr Arg Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg 
                245                 250                 255     


Ser Ser Leu Arg Cys Cys Arg Ile Arg Phe Thr Trp Ala Leu Ala Leu 
            260                 265                 270         


Leu Gln Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly 
        275                 280                 285             


Phe Leu Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly 
    290                 295                 300                 


Leu Leu Gly Gly Ala Ala Tyr Val Asn Thr Phe His Asn Ile Ala Leu 
305                 310                 315                 320 


Glu Thr Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Thr Cys Ile 
                325                 330                 335     


Ser Asp Thr Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu 
            340                 345                 350         


His Asp Phe Leu Cys Gln Leu Ser 
        355                 360 


<210>  276
<211>  311
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CLN6 TRANSMEMBRANE ER PROTEIN (CLN6) <Accession No.: 
NP_060352.1>

<400>  276

Met Glu Ala Thr Arg Arg Arg Gln His Leu Gly Ala Thr Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gln Leu Gly Ala Ser Phe Leu Gln Ala Arg His Gly Ser Val 
            20                  25                  30          


Ser Ala Asp Glu Ala Ala Arg Thr Ala Pro Phe His Leu Asp Leu Trp 
        35                  40                  45              


Phe Tyr Phe Thr Leu Gln Asn Trp Val Leu Asp Phe Gly Arg Pro Ile 
    50                  55                  60                  


Ala Met Leu Val Phe Pro Leu Glu Trp Phe Pro Leu Asn Lys Pro Ser 
65                  70                  75                  80  


Val Gly Asp Tyr Phe His Met Ala Tyr Asn Val Ile Thr Pro Phe Leu 
                85                  90                  95      


Leu Leu Lys Leu Ile Glu Arg Ser Pro Arg Thr Leu Pro Arg Ser Ile 
            100                 105                 110         


Thr Tyr Val Ser Ile Ile Ile Phe Ile Met Gly Ala Ser Ile His Leu 
        115                 120                 125             


Val Gly Asp Ser Val Asn His Arg Leu Leu Phe Ser Gly Tyr Gln His 
    130                 135                 140                 


His Leu Ser Val Arg Glu Asn Pro Ile Ile Lys Asn Leu Lys Pro Glu 
145                 150                 155                 160 


Thr Leu Ile Asp Ser Phe Glu Leu Leu Tyr Tyr Tyr Asp Glu Tyr Leu 
                165                 170                 175     


Gly His Cys Met Trp Tyr Ile Pro Phe Phe Leu Ile Leu Phe Met Tyr 
            180                 185                 190         


Phe Ser Gly Cys Phe Thr Ala Ser Lys Ala Glu Ser Leu Ile Pro Gly 
        195                 200                 205             


Pro Ala Leu Leu Leu Val Ala Pro Ser Gly Leu Tyr Tyr Trp Tyr Leu 
    210                 215                 220                 


Val Thr Glu Gly Gln Ile Phe Ile Leu Phe Ile Phe Thr Phe Phe Ala 
225                 230                 235                 240 


Met Leu Ala Leu Val Leu His Gln Lys Arg Lys Arg Leu Phe Leu Asp 
                245                 250                 255     


Ser Asn Gly Leu Phe Leu Phe Ser Ser Phe Ala Leu Thr Leu Leu Leu 
            260                 265                 270         


Val Ala Leu Trp Val Ala Trp Leu Trp Asn Asp Pro Val Leu Arg Lys 
        275                 280                 285             


Lys Tyr Pro Gly Val Ile Tyr Val Pro Glu Pro Trp Ala Phe Tyr Thr 
    290                 295                 300                 


Leu His Val Ser Ser Arg His 
305                 310     


<210>  277
<211>  518
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 8 (MFSD8) 
<Accession No.: AAH29503.1>

<400>  277

Met Ala Gly Leu Arg Asn Glu Ser Glu Gln Glu Pro Leu Leu Gly Asp 
1               5                   10                  15      


Thr Pro Gly Ser Arg Glu Trp Asp Ile Leu Glu Thr Glu Glu His Tyr 
            20                  25                  30          


Lys Ser Arg Trp Arg Ser Ile Arg Ile Leu Tyr Leu Thr Met Phe Leu 
        35                  40                  45              


Ser Ser Val Gly Phe Ser Val Val Met Met Ser Ile Trp Pro Tyr Leu 
    50                  55                  60                  


Gln Lys Ile Asp Pro Thr Ala Asp Thr Ser Phe Leu Gly Trp Val Ile 
65                  70                  75                  80  


Ala Ser Tyr Ser Leu Gly Gln Met Val Ala Ser Pro Ile Phe Gly Leu 
                85                  90                  95      


Trp Ser Asn Tyr Arg Pro Arg Lys Glu Pro Leu Ile Val Ser Ile Leu 
            100                 105                 110         


Ile Ser Val Ala Ala Asn Cys Leu Tyr Ala Tyr Leu His Ile Pro Ala 
        115                 120                 125             


Ser His Asn Lys Tyr Tyr Met Leu Val Ala Arg Gly Leu Leu Gly Ile 
    130                 135                 140                 


Gly Ala Gly Asn Val Ala Val Val Arg Ser Tyr Thr Ala Gly Ala Thr 
145                 150                 155                 160 


Ser Leu Gln Glu Arg Thr Ser Ser Met Ala Asn Ile Ser Met Cys Gln 
                165                 170                 175     


Ala Leu Gly Phe Ile Leu Gly Pro Val Phe Gln Thr Cys Phe Thr Phe 
            180                 185                 190         


Leu Gly Glu Lys Gly Val Thr Trp Asp Val Ile Lys Leu Gln Ile Asn 
        195                 200                 205             


Met Tyr Thr Thr Pro Val Leu Leu Ser Ala Phe Leu Gly Ile Leu Asn 
    210                 215                 220                 


Ile Ile Leu Ile Leu Ala Ile Leu Arg Glu His Arg Val Asp Asp Ser 
225                 230                 235                 240 


Gly Arg Gln Cys Lys Ser Ile Asn Phe Glu Glu Ala Ser Thr Asp Glu 
                245                 250                 255     


Ala Gln Val Pro Gln Gly Asn Ile Asp Gln Val Ala Val Val Ala Ile 
            260                 265                 270         


Asn Val Leu Phe Phe Val Thr Leu Phe Ile Phe Ala Leu Phe Glu Thr 
        275                 280                 285             


Ile Ile Thr Pro Leu Thr Met Asp Met Tyr Ala Trp Thr Gln Glu Gln 
    290                 295                 300                 


Ala Val Leu Tyr Asn Gly Ile Ile Leu Ala Ala Leu Gly Val Glu Ala 
305                 310                 315                 320 


Val Val Ile Phe Leu Gly Val Lys Leu Leu Ser Lys Lys Ile Gly Glu 
                325                 330                 335     


Arg Ala Ile Leu Leu Gly Gly Leu Ile Val Val Trp Val Gly Phe Phe 
            340                 345                 350         


Ile Leu Leu Pro Trp Gly Asn Gln Phe Pro Lys Ile Gln Trp Glu Asp 
        355                 360                 365             


Leu His Asn Asn Ser Ile Pro Asn Thr Thr Phe Gly Glu Ile Ile Ile 
    370                 375                 380                 


Gly Leu Trp Lys Ser Pro Met Glu Asp Asp Asn Glu Arg Pro Thr Gly 
385                 390                 395                 400 


Cys Ser Ile Glu Gln Ala Trp Cys Leu Tyr Thr Pro Val Ile His Leu 
                405                 410                 415     


Ala Gln Phe Leu Thr Ser Ala Val Leu Ile Gly Leu Gly Tyr Pro Val 
            420                 425                 430         


Cys Asn Leu Met Ser Tyr Thr Leu Tyr Ser Lys Ile Leu Gly Pro Lys 
        435                 440                 445             


Pro Gln Gly Val Tyr Met Gly Trp Leu Thr Ala Ser Gly Ser Gly Ala 
    450                 455                 460                 


Arg Ile Leu Gly Pro Met Phe Ile Ser Gln Val Tyr Ala His Trp Gly 
465                 470                 475                 480 


Pro Arg Trp Ala Phe Ser Leu Val Cys Gly Ile Ile Val Leu Thr Ile 
                485                 490                 495     


Thr Leu Leu Gly Val Val Tyr Lys Arg Leu Ile Ala Leu Ser Val Arg 
            500                 505                 510         


Tyr Gly Arg Ile Gln Glu 
        515             


<210>  278
<211>  2215
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A) <Accession No.: AAB03679.1>

<400>  278

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Cys Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Thr Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Ile Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Lys Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Gly  Ser Arg Ser Gly Lys  
    2210                 2215 


<210>  279
<211>  1178
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A), ISOFORM CRA_A  <Accession No.: EAW75018.1>

<400>  279

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Ser Val  Pro Gly Gly 
    1160                 1165                 1170             


Gly Asp  Thr Arg Ala 
    1175             


<210>  280
<211>  2215
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A), ISOFORM CRA_B <Accession No.: EAW75019.1>

<400>  280

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Cys Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Thr Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Ile Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Lys Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Gly  Ser Arg Ser Gly Lys  
    2210                 2215 


<210>  281
<211>  2217
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A), ISOFORM CRA_C <Accession No.: EAW75020.1>

<400>  281

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Cys Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Asp Ile Pro Val Leu  Lys Tyr Met Gly Asp  Tyr Pro Ser 
    1775                 1780                 1785             


Lys Arg  Thr Arg Ser Val Asn  Glu Leu Thr Asp Gln  Ile Phe Glu 
    1790                 1795                 1800             


Gly Pro  Leu Lys Ala Glu Pro  Leu Lys Asp Glu Ala  Tyr Val Gln 
    1805                 1810                 1815             


Ile Leu  Lys Gln Leu Thr Asp  Asn His Ile Arg Tyr  Ser Glu Glu 
    1820                 1825                 1830             


Arg Gly  Trp Glu Leu Leu Trp  Leu Cys Thr Gly Leu  Phe Pro Pro 
    1835                 1840                 1845             


Ser Asn  Ile Leu Leu Pro His  Val Gln Arg Phe Leu  Gln Ser Arg 
    1850                 1855                 1860             


Lys His  Cys Pro Leu Ala Ile  Asp Cys Leu Gln Arg  Leu Gln Lys 
    1865                 1870                 1875             


Ala Leu  Arg Asn Gly Ser Arg  Lys Tyr Pro Pro His  Leu Val Glu 
    1880                 1885                 1890             


Val Glu  Ala Ile Gln His Lys  Thr Thr Gln Ile Phe  His Lys Val 
    1895                 1900                 1905             


Tyr Phe  Pro Asp Asp Thr Asp  Glu Ala Phe Glu Val  Glu Ser Ser 
    1910                 1915                 1920             


Thr Lys  Ala Lys Asp Phe Cys  Gln Asn Ile Ala Thr  Arg Leu Leu 
    1925                 1930                 1935             


Leu Lys  Ser Ser Glu Gly Phe  Ser Leu Phe Val Lys  Ile Ala Asp 
    1940                 1945                 1950             


Lys Val  Ile Ser Val Pro Glu  Asn Asp Phe Phe Phe  Asp Phe Val 
    1955                 1960                 1965             


Arg His  Leu Thr Asp Trp Ile  Lys Lys Ala Arg Pro  Ile Lys Asp 
    1970                 1975                 1980             


Gly Ile  Val Pro Ser Leu Thr  Tyr Gln Val Phe Phe  Met Lys Lys 
    1985                 1990                 1995             


Leu Trp  Thr Thr Thr Val Pro  Gly Lys Asp Pro Met  Ala Asp Ser 
    2000                 2005                 2010             


Ile Phe  His Tyr Tyr Gln Glu  Leu Pro Lys Tyr Leu  Arg Gly Tyr 
    2015                 2020                 2025             


His Lys  Cys Thr Arg Glu Glu  Val Leu Gln Leu Gly  Ala Leu Ile 
    2030                 2035                 2040             


Tyr Arg  Val Lys Phe Glu Glu  Asp Lys Ser Tyr Phe  Pro Ser Ile 
    2045                 2050                 2055             


Pro Lys  Leu Leu Arg Glu Leu  Val Pro Gln Asp Leu  Ile Arg Gln 
    2060                 2065                 2070             


Val Ser  Pro Asp Asp Trp Lys  Arg Ser Ile Val Ala  Tyr Phe Asn 
    2075                 2080                 2085             


Lys His  Ala Gly Lys Ser Lys  Glu Glu Ala Lys Leu  Ala Phe Leu 
    2090                 2095                 2100             


Lys Leu  Ile Phe Lys Trp Pro  Thr Phe Gly Ser Ala  Phe Phe Glu 
    2105                 2110                 2115             


Val Lys  Gln Thr Thr Glu Pro  Asn Phe Pro Glu Ile  Leu Leu Ile 
    2120                 2125                 2130             


Ala Ile  Asn Lys Tyr Gly Val  Ser Leu Ile Asp Pro  Lys Thr Lys 
    2135                 2140                 2145             


Asp Ile  Leu Thr Thr His Pro  Phe Thr Lys Ile Ser  Asn Trp Ser 
    2150                 2155                 2160             


Ser Gly  Asn Thr Tyr Phe His  Ile Thr Ile Gly Asn  Leu Val Arg 
    2165                 2170                 2175             


Gly Ser  Lys Leu Leu Cys Glu  Thr Ser Leu Gly Tyr  Lys Met Asp 
    2180                 2185                 2190             


Asp Leu  Leu Thr Ser Tyr Ile  Ser Gln Met Leu Thr  Ala Met Ser 
    2195                 2200                 2205             


Lys Gln  Arg Gly Ser Arg Ser  Gly Lys 
    2210                 2215         


<210>  282
<211>  791
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A), ISOFORM CRA_D <Accession No.: EAW75021.1>

<400>  282

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Cys Val Phe Pro Pro Ala Pro 
        755                 760                 765             


Pro Leu Leu Ser Pro His Thr Gly Val Arg Val Val Phe Gly Ser Pro 
    770                 775                 780                 


Leu Leu Cys Pro His Glu His 
785                 790     


<210>  283
<211>  2177
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A), ISOFORM CRA_E <Accession No.: EAW75022.1>

<400>  283

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Gly Ala  Lys Thr Thr Ala Pro  Ser Phe Thr 
    1520                 1525                 1530             


Leu Ala  Thr Ile Lys Gly Asp  Glu Tyr Thr Phe Thr  Ser Ser Asn 
    1535                 1540                 1545             


Ala Glu  Asp Ile Arg Asp Leu  Val Val Thr Phe Leu  Glu Gly Leu 
    1550                 1555                 1560             


Arg Lys  Arg Ser Lys Tyr Val  Val Ala Leu Gln Asp  Asn Pro Asn 
    1565                 1570                 1575             


Pro Ala  Gly Glu Glu Ser Gly  Phe Leu Ser Phe Ala  Lys Gly Asp 
    1580                 1585                 1590             


Leu Ile  Ile Leu Asp His Asp  Thr Gly Glu Gln Val  Met Asn Ser 
    1595                 1600                 1605             


Gly Trp  Ala Asn Gly Ile Asn  Glu Arg Thr Lys Gln  Arg Gly Asp 
    1610                 1615                 1620             


Phe Pro  Thr Asp Cys Val Tyr  Val Met Pro Thr Val  Thr Met Pro 
    1625                 1630                 1635             


Pro Arg  Glu Ile Val Ala Leu  Val Thr Met Thr Pro  Asp Gln Arg 
    1640                 1645                 1650             


Gln Asp  Val Val Arg Leu Leu  Gln Leu Arg Thr Ala  Glu Pro Glu 
    1655                 1660                 1665             


Val Arg  Ala Lys Pro Tyr Thr  Leu Glu Glu Phe Ser  Tyr Asp Tyr 
    1670                 1675                 1680             


Phe Arg  Pro Pro Pro Lys His  Thr Leu Ser Arg Val  Met Val Ser 
    1685                 1690                 1695             


Lys Ala  Arg Gly Lys Asp Arg  Leu Trp Ser His Thr  Arg Glu Pro 
    1700                 1705                 1710             


Leu Lys  Gln Ala Leu Leu Lys  Lys Leu Leu Gly Ser  Glu Glu Leu 
    1715                 1720                 1725             


Ser Gln  Glu Ala Cys Leu Ala  Phe Ile Asp Ile Pro  Val Leu Lys 
    1730                 1735                 1740             


Tyr Met  Gly Asp Tyr Pro Ser  Lys Arg Thr Arg Ser  Val Asn Glu 
    1745                 1750                 1755             


Leu Thr  Asp Gln Ile Phe Glu  Gly Pro Leu Lys Ala  Glu Pro Leu 
    1760                 1765                 1770             


Lys Asp  Glu Ala Tyr Val Gln  Ile Leu Lys Gln Leu  Thr Asp Asn 
    1775                 1780                 1785             


His Ile  Arg Tyr Ser Glu Glu  Arg Gly Trp Glu Leu  Leu Trp Leu 
    1790                 1795                 1800             


Cys Thr  Gly Leu Phe Pro Pro  Ser Asn Ile Leu Leu  Pro His Val 
    1805                 1810                 1815             


Gln Arg  Phe Leu Gln Ser Arg  Lys His Cys Pro Leu  Ala Ile Asp 
    1820                 1825                 1830             


Cys Leu  Gln Arg Leu Gln Lys  Ala Leu Arg Asn Gly  Ser Arg Lys 
    1835                 1840                 1845             


Tyr Pro  Pro His Leu Val Glu  Val Glu Ala Ile Gln  His Lys Thr 
    1850                 1855                 1860             


Thr Gln  Ile Phe His Lys Val  Tyr Phe Pro Asp Asp  Thr Asp Glu 
    1865                 1870                 1875             


Ala Phe  Glu Val Glu Ser Ser  Thr Lys Ala Lys Asp  Phe Cys Gln 
    1880                 1885                 1890             


Asn Ile  Ala Thr Arg Leu Leu  Leu Lys Ser Ser Glu  Gly Phe Ser 
    1895                 1900                 1905             


Leu Phe  Val Lys Ile Ala Asp  Lys Val Ile Ser Val  Pro Glu Asn 
    1910                 1915                 1920             


Asp Phe  Phe Phe Asp Phe Val  Arg His Leu Thr Asp  Trp Ile Lys 
    1925                 1930                 1935             


Lys Ala  Arg Pro Ile Lys Asp  Gly Ile Val Pro Ser  Leu Thr Tyr 
    1940                 1945                 1950             


Gln Val  Phe Phe Met Lys Lys  Leu Trp Thr Thr Thr  Val Pro Gly 
    1955                 1960                 1965             


Lys Asp  Pro Met Ala Asp Ser  Ile Phe His Tyr Tyr  Gln Glu Leu 
    1970                 1975                 1980             


Pro Lys  Tyr Leu Arg Gly Tyr  His Lys Cys Thr Arg  Glu Glu Val 
    1985                 1990                 1995             


Leu Gln  Leu Gly Ala Leu Ile  Tyr Arg Val Lys Phe  Glu Glu Asp 
    2000                 2005                 2010             


Lys Ser  Tyr Phe Pro Ser Ile  Pro Lys Leu Leu Arg  Glu Leu Val 
    2015                 2020                 2025             


Pro Gln  Asp Leu Ile Arg Gln  Val Ser Pro Asp Asp  Trp Lys Arg 
    2030                 2035                 2040             


Ser Ile  Val Ala Tyr Phe Asn  Lys His Ala Gly Lys  Ser Lys Glu 
    2045                 2050                 2055             


Glu Ala  Lys Leu Ala Phe Leu  Lys Leu Ile Phe Lys  Trp Pro Thr 
    2060                 2065                 2070             


Phe Gly  Ser Ala Phe Phe Glu  Gln Thr Thr Glu Pro  Asn Phe Pro 
    2075                 2080                 2085             


Glu Ile  Leu Leu Ile Ala Ile  Asn Lys Tyr Gly Val  Ser Leu Ile 
    2090                 2095                 2100             


Asp Pro  Lys Thr Lys Asp Ile  Leu Thr Thr His Pro  Phe Thr Lys 
    2105                 2110                 2115             


Ile Ser  Asn Trp Ser Ser Gly  Asn Thr Tyr Phe His  Ile Thr Ile 
    2120                 2125                 2130             


Gly Asn  Leu Val Arg Gly Ser  Lys Leu Leu Cys Glu  Thr Ser Leu 
    2135                 2140                 2145             


Gly Tyr  Lys Met Asp Asp Leu  Leu Thr Ser Tyr Ile  Ser Gln Met 
    2150                 2155                 2160             


Leu Thr  Ala Met Ser Lys Gln  Arg Gly Ser Arg Ser  Gly Lys 
    2165                 2170                 2175         


<210>  284
<211>  1958
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MYOSIN VIIA (MYO7A), ISOFORM CRA_F <Accession No.: EAW75023.1>

<400>  284

Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu Gly 
1               5                   10                  15      


Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr Cys 
            20                  25                  30          


Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala Met 
        35                  40                  45              


Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys Leu 
    50                  55                  60                  


Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg Thr 
65                  70                  75                  80  


Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu Ala 
                85                  90                  95      


Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser Cys 
            100                 105                 110         


Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr Pro 
        115                 120                 125             


Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys Gly 
    130                 135                 140                 


Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala Ala 
145                 150                 155                 160 


Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser Ile 
                165                 170                 175     


Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser Phe 
            180                 185                 190         


Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe Phe 
        195                 200                 205             


Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu Ser 
    210                 215                 220                 


Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu Asp 
225                 230                 235                 240 


Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu Glu 
                245                 250                 255     


Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu Asn 
            260                 265                 270         


Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn His 
        275                 280                 285             


Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr Glu 
    290                 295                 300                 


Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp Ile 
305                 310                 315                 320 


Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile Phe 
                325                 330                 335     


Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro Thr 
            340                 345                 350         


Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr Leu 
        355                 360                 365             


Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu Phe 
    370                 375                 380                 


Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu Arg 
385                 390                 395                 400 


Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr Pro 
                405                 410                 415     


Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu Leu 
            420                 425                 430         


Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr Cys 
        435                 440                 445             


Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln Ile 
    450                 455                 460                 


Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu Glu 
465                 470                 475                 480 


Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln Lys 
                485                 490                 495     


Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys Asn 
            500                 505                 510         


Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg Lys 
        515                 520                 525             


Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu His 
    530                 535                 540                 


Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg Ile 
545                 550                 555                 560 


Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala Phe 
                565                 570                 575     


Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg Gly 
            580                 585                 590         


Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu Trp 
        595                 600                 605             


Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu Arg 
    610                 615                 620                 


Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys His 
625                 630                 635                 640 


Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu Leu 
                645                 650                 655     


Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln Met 
            660                 665                 670         


Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp Lys 
        675                 680                 685             


Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu Gly 
    690                 695                 700                 


Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu Met 
705                 710                 715                 720 


Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp Glu 
                725                 730                 735     


Glu Asp Leu Ser Glu Tyr Lys Phe Ala Lys Phe Ala Ala Thr Tyr Phe 
            740                 745                 750         


Gln Gly Thr Thr Thr His Ser Tyr Thr Arg Arg Pro Leu Lys Gln Pro 
        755                 760                 765             


Leu Leu Tyr His Asp Asp Glu Gly Asp Gln Leu Ala Ala Leu Ala Val 
    770                 775                 780                 


Trp Ile Thr Ile Leu Arg Phe Met Gly Asp Leu Pro Glu Pro Lys Tyr 
785                 790                 795                 800 


His Thr Ala Met Ser Asp Gly Ser Glu Lys Ile Pro Val Met Thr Lys 
                805                 810                 815     


Ile Tyr Glu Thr Leu Gly Lys Lys Thr Tyr Lys Arg Glu Leu Gln Ala 
            820                 825                 830         


Leu Gln Gly Glu Gly Glu Ala Gln Leu Pro Glu Gly Gln Lys Lys Ser 
        835                 840                 845             


Ser Val Arg His Lys Leu Val His Leu Thr Leu Lys Lys Lys Ser Lys 
    850                 855                 860                 


Leu Thr Glu Glu Val Thr Lys Arg Leu His Asp Gly Glu Ser Thr Val 
865                 870                 875                 880 


Gln Gly Asn Ser Met Leu Glu Asp Arg Pro Thr Ser Asn Leu Glu Lys 
                885                 890                 895     


Leu His Phe Ile Ile Gly Asn Gly Ile Leu Arg Pro Ala Leu Arg Asp 
            900                 905                 910         


Glu Ile Tyr Cys Gln Ile Ser Lys Gln Leu Thr His Asn Pro Ser Lys 
        915                 920                 925             


Ser Ser Tyr Ala Arg Gly Trp Ile Leu Val Ser Leu Cys Val Gly Cys 
    930                 935                 940                 


Phe Ala Pro Ser Glu Lys Phe Val Lys Tyr Leu Arg Asn Phe Ile His 
945                 950                 955                 960 


Gly Gly Pro Pro Gly Tyr Ala Pro Tyr Cys Glu Glu Arg Leu Arg Arg 
                965                 970                 975     


Thr Phe Val Asn Gly Thr Arg Thr Gln Pro Pro Ser Trp Leu Glu Leu 
            980                 985                 990         


Gln Ala Thr Lys Ser Lys Lys Pro  Ile Met Leu Pro Val  Thr Phe Met 
        995                 1000                 1005             


Asp Gly  Thr Thr Lys Thr Leu  Leu Thr Asp Ser Ala  Thr Thr Ala 
    1010                 1015                 1020             


Lys Glu  Leu Cys Asn Ala Leu  Ala Asp Lys Ile Ser  Leu Lys Asp 
    1025                 1030                 1035             


Arg Phe  Gly Phe Ser Leu Tyr  Ile Ala Leu Phe Asp  Lys Val Ser 
    1040                 1045                 1050             


Ser Leu  Gly Ser Gly Ser Asp  His Val Met Asp Ala  Ile Ser Gln 
    1055                 1060                 1065             


Cys Glu  Gln Tyr Ala Lys Glu  Gln Gly Ala Gln Glu  Arg Asn Ala 
    1070                 1075                 1080             


Pro Trp  Arg Leu Phe Phe Arg  Lys Glu Val Phe Thr  Pro Trp His 
    1085                 1090                 1095             


Ser Pro  Ser Glu Asp Asn Val  Ala Thr Asn Leu Ile  Tyr Gln Gln 
    1100                 1105                 1110             


Val Val  Arg Gly Val Lys Phe  Gly Glu Tyr Arg Cys  Glu Lys Glu 
    1115                 1120                 1125             


Asp Asp  Leu Ala Glu Leu Ala  Ser Gln Gln Tyr Phe  Val Asp Tyr 
    1130                 1135                 1140             


Gly Ser  Glu Met Ile Leu Glu  Arg Leu Leu Asn Leu  Val Pro Thr 
    1145                 1150                 1155             


Tyr Ile  Pro Asp Arg Glu Ile  Thr Pro Leu Lys Thr  Leu Glu Lys 
    1160                 1165                 1170             


Trp Ala  Gln Leu Ala Ile Ala  Ala His Lys Lys Gly  Ile Tyr Ala 
    1175                 1180                 1185             


Gln Arg  Arg Thr Asp Ala Gln  Lys Val Lys Glu Asp  Val Val Ser 
    1190                 1195                 1200             


Tyr Ala  Arg Phe Lys Trp Pro  Leu Leu Phe Ser Arg  Phe Tyr Glu 
    1205                 1210                 1215             


Ala Tyr  Lys Phe Ser Gly Pro  Ser Leu Pro Lys Asn  Asp Val Ile 
    1220                 1225                 1230             


Val Ala  Val Asn Trp Thr Gly  Val Tyr Phe Val Asp  Glu Gln Glu 
    1235                 1240                 1245             


Gln Val  Leu Leu Glu Leu Ser  Phe Pro Glu Ile Met  Ala Val Ser 
    1250                 1255                 1260             


Ser Ser  Arg Glu Cys Arg Val  Trp Leu Ser Leu Gly  Cys Ser Asp 
    1265                 1270                 1275             


Leu Gly  Cys Ala Ala Pro His  Ser Gly Trp Ala Gly  Leu Thr Pro 
    1280                 1285                 1290             


Ala Gly  Pro Cys Ser Pro Cys  Trp Ser Cys Arg Gly  Ala Lys Thr 
    1295                 1300                 1305             


Thr Ala  Pro Ser Phe Thr Leu  Ala Thr Ile Lys Gly  Asp Glu Tyr 
    1310                 1315                 1320             


Thr Phe  Thr Ser Ser Asn Ala  Glu Asp Ile Arg Asp  Leu Val Val 
    1325                 1330                 1335             


Thr Phe  Leu Glu Gly Leu Arg  Lys Arg Ser Lys Tyr  Val Val Ala 
    1340                 1345                 1350             


Leu Gln  Asp Asn Pro Asn Pro  Ala Gly Glu Glu Ser  Gly Phe Leu 
    1355                 1360                 1365             


Ser Phe  Ala Lys Gly Asp Leu  Ile Ile Leu Asp His  Asp Thr Gly 
    1370                 1375                 1380             


Glu Gln  Val Met Asn Ser Gly  Trp Ala Asn Gly Ile  Asn Glu Arg 
    1385                 1390                 1395             


Thr Lys  Gln Arg Gly Asp Phe  Pro Thr Asp Cys Val  Tyr Val Met 
    1400                 1405                 1410             


Pro Thr  Val Thr Met Pro Pro  Arg Glu Ile Val Ala  Leu Val Thr 
    1415                 1420                 1425             


Met Thr  Pro Asp Gln Arg Gln  Asp Val Val Arg Leu  Leu Gln Leu 
    1430                 1435                 1440             


Arg Thr  Ala Glu Pro Glu Val  Arg Ala Lys Pro Tyr  Thr Leu Glu 
    1445                 1450                 1455             


Glu Phe  Ser Tyr Asp Tyr Phe  Arg Pro Pro Pro Lys  His Thr Leu 
    1460                 1465                 1470             


Ser Arg  Val Met Val Ser Lys  Ala Arg Gly Lys Asp  Arg Leu Trp 
    1475                 1480                 1485             


Ser His  Thr Arg Glu Pro Leu  Lys Gln Ala Leu Leu  Lys Lys Leu 
    1490                 1495                 1500             


Leu Gly  Ser Glu Glu Leu Ser  Gln Glu Ala Cys Leu  Ala Phe Ile 
    1505                 1510                 1515             


Ala Val  Leu Lys Tyr Met Gly  Asp Tyr Pro Ser Lys  Arg Thr Arg 
    1520                 1525                 1530             


Ser Val  Asn Glu Leu Thr Asp  Gln Ile Phe Glu Gly  Pro Leu Lys 
    1535                 1540                 1545             


Ala Glu  Pro Leu Lys Asp Glu  Ala Tyr Val Gln Ile  Leu Lys Gln 
    1550                 1555                 1560             


Leu Thr  Asp Asn His Ile Arg  Tyr Ser Glu Glu Arg  Gly Trp Glu 
    1565                 1570                 1575             


Leu Leu  Trp Leu Cys Thr Gly  Leu Phe Pro Pro Ser  Asn Ile Leu 
    1580                 1585                 1590             


Leu Pro  His Val Gln Arg Phe  Leu Gln Ser Arg Lys  His Cys Pro 
    1595                 1600                 1605             


Leu Ala  Ile Asp Cys Leu Gln  Arg Leu Gln Lys Ala  Leu Arg Asn 
    1610                 1615                 1620             


Gly Ser  Arg Lys Tyr Pro Pro  His Leu Val Glu Val  Glu Ala Ile 
    1625                 1630                 1635             


Gln His  Lys Thr Thr Gln Ile  Phe His Lys Val Tyr  Phe Pro Asp 
    1640                 1645                 1650             


Asp Thr  Asp Glu Ala Phe Glu  Val Glu Ser Ser Thr  Lys Ala Lys 
    1655                 1660                 1665             


Asp Phe  Cys Gln Asn Ile Ala  Thr Arg Leu Leu Leu  Lys Ser Ser 
    1670                 1675                 1680             


Glu Gly  Phe Ser Leu Phe Val  Lys Ile Ala Asp Lys  Val Ile Ser 
    1685                 1690                 1695             


Val Pro  Glu Asn Asp Phe Phe  Phe Asp Phe Val Arg  His Leu Thr 
    1700                 1705                 1710             


Asp Trp  Ile Lys Lys Ala Arg  Pro Ile Lys Asp Gly  Ile Val Pro 
    1715                 1720                 1725             


Ser Leu  Thr Tyr Gln Val Phe  Phe Met Lys Lys Leu  Trp Thr Thr 
    1730                 1735                 1740             


Thr Val  Pro Gly Lys Asp Pro  Met Ala Asp Ser Ile  Phe His Tyr 
    1745                 1750                 1755             


Tyr Gln  Glu Leu Pro Lys Tyr  Leu Arg Gly Tyr His  Lys Cys Thr 
    1760                 1765                 1770             


Arg Glu  Glu Val Leu Gln Leu  Gly Ala Leu Ile Tyr  Arg Val Lys 
    1775                 1780                 1785             


Phe Glu  Glu Asp Lys Ser Tyr  Phe Pro Ser Ile Pro  Lys Leu Leu 
    1790                 1795                 1800             


Arg Glu  Leu Val Pro Gln Asp  Leu Ile Arg Gln Val  Ser Pro Asp 
    1805                 1810                 1815             


Asp Trp  Lys Arg Ser Ile Val  Ala Tyr Phe Asn Lys  His Ala Gly 
    1820                 1825                 1830             


Lys Ser  Lys Glu Glu Ala Lys  Leu Ala Phe Leu Lys  Leu Ile Phe 
    1835                 1840                 1845             


Lys Trp  Pro Thr Phe Gly Ser  Ala Phe Phe Glu Val  Lys Gln Thr 
    1850                 1855                 1860             


Thr Glu  Pro Asn Phe Pro Glu  Ile Leu Leu Ile Ala  Ile Asn Lys 
    1865                 1870                 1875             


Tyr Gly  Val Ser Leu Ile Asp  Pro Lys Thr Lys Asp  Ile Leu Thr 
    1880                 1885                 1890             


Thr His  Pro Phe Thr Lys Ile  Ser Asn Trp Ser Ser  Gly Asn Thr 
    1895                 1900                 1905             


Tyr Phe  His Ile Thr Ile Gly  Asn Leu Val Arg Gly  Ser Lys Leu 
    1910                 1915                 1920             


Leu Cys  Glu Thr Ser Leu Gly  Tyr Lys Met Asp Asp  Leu Leu Thr 
    1925                 1930                 1935             


Ser Tyr  Ile Ser Gln Met Leu  Thr Ala Met Ser Lys  Gln Arg Gly 
    1940                 1945                 1950             


Ser Arg  Ser Gly Lys 
    1955             


<210>  285
<211>  3354
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CADHERIN RELATED 23 (CDH23) <Accession No.: AAG27034.2>

<400>  285

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asp Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Lys Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Thr  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr His  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  286
<211>  1955
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROTOCADHERIN RELATED 15 (PCDH15) <Accession No.: AAK31581.1>

<400>  286

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Ser Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Leu Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Gln Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Arg Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Ile Leu Phe 
    1445                 1450                 1455             


Leu Leu  Tyr His Phe Gln Gln  Ser Arg Gly Asn Asn  Ser Val Ser 
    1460                 1465                 1470             


Glu Asp  Arg Lys His Gln Gln  Val Val Met Pro Phe  Ser Ser Asn 
    1475                 1480                 1485             


Thr Ile  Glu Ala His Lys Ser  Ala His Val Asp Gly  Ser Leu Lys 
    1490                 1495                 1500             


Ser Asn  Lys Leu Lys Ser Ala  Arg Lys Phe Thr Phe  Leu Ser Asp 
    1505                 1510                 1515             


Glu Asp  Asp Leu Ser Ala His  Asn Pro Leu Tyr Lys  Glu Asn Ile 
    1520                 1525                 1530             


Ser Gln  Val Ser Thr Asn Ser  Asp Ile Ser Gln Arg  Thr Asp Phe 
    1535                 1540                 1545             


Val Asp  Pro Phe Ser Pro Lys  Ile Gln Ala Lys Ser  Lys Ser Leu 
    1550                 1555                 1560             


Arg Gly  Pro Arg Glu Lys Ile  Gln Arg Leu Trp Ser  Gln Ser Val 
    1565                 1570                 1575             


Ser Leu  Pro Arg Arg Leu Met  Arg Lys Val Pro Asn  Arg Pro Glu 
    1580                 1585                 1590             


Ile Ile  Asp Leu Gln Gln Trp  Gln Gly Thr Arg Gln  Lys Ala Glu 
    1595                 1600                 1605             


Asn Glu  Asn Thr Gly Ile Cys  Thr Asn Lys Arg Gly  Ser Ser Asn 
    1610                 1615                 1620             


Pro Leu  Leu Thr Thr Glu Glu  Ala Asn Leu Thr Glu  Lys Glu Glu 
    1625                 1630                 1635             


Ile Arg  Gln Gly Glu Thr Leu  Met Ile Glu Gly Thr  Glu Gln Leu 
    1640                 1645                 1650             


Lys Ser  Leu Ser Ser Asp Ser  Ser Phe Cys Phe Pro  Arg Pro His 
    1655                 1660                 1665             


Phe Ser  Phe Ser Thr Leu Pro  Thr Val Ser Arg Thr  Val Glu Leu 
    1670                 1675                 1680             


Lys Ser  Glu Pro Asn Val Ile  Ser Ser Pro Ala Glu  Cys Ser Leu 
    1685                 1690                 1695             


Glu Leu  Ser Pro Ser Arg Pro  Cys Val Leu His Ser  Ser Leu Ser 
    1700                 1705                 1710             


Arg Arg  Glu Thr Pro Ile Cys  Met Leu Pro Ile Glu  Thr Glu Arg 
    1715                 1720                 1725             


Asn Ile  Phe Glu Asn Phe Ala  His Pro Pro Asn Ile  Ser Pro Ser 
    1730                 1735                 1740             


Ala Cys  Pro Leu Pro Pro Pro  Pro Pro Ile Ser Pro  Pro Ser Pro 
    1745                 1750                 1755             


Pro Pro  Ala Pro Ala Pro Leu  Ala Pro Pro Pro Asp  Ile Ser Pro 
    1760                 1765                 1770             


Phe Ser  Leu Phe Cys Pro Pro  Pro Ser Pro Pro Ser  Ile Pro Leu 
    1775                 1780                 1785             


Pro Leu  Pro Pro Pro Thr Phe  Phe Pro Leu Ser Val  Ser Thr Ser 
    1790                 1795                 1800             


Gly Pro  Pro Thr Pro Pro Leu  Leu Pro Pro Phe Pro  Thr Pro Leu 
    1805                 1810                 1815             


Pro Pro  Pro Pro Pro Ser Ile  Pro Cys Pro Pro Pro  Pro Ser Ala 
    1820                 1825                 1830             


Ser Phe  Leu Ser Thr Glu Cys  Val Cys Ile Thr Gly  Val Lys Cys 
    1835                 1840                 1845             


Thr Thr  Asn Leu Met Pro Ala  Glu Lys Ile Lys Ser  Ser Met Thr 
    1850                 1855                 1860             


Gln Leu  Ser Thr Thr Thr Val  Cys Lys Thr Asp Pro  Gln Arg Glu 
    1865                 1870                 1875             


Pro Lys  Gly Ile Leu Arg His  Val Lys Asn Leu Ala  Glu Leu Glu 
    1880                 1885                 1890             


Lys Ser  Val Ala Asn Met Tyr  Ser Gln Ile Glu Lys  Asn Tyr Leu 
    1895                 1900                 1905             


Arg Thr  Asn Val Ser Glu Leu  Gln Thr Met Cys Pro  Ser Glu Val 
    1910                 1915                 1920             


Thr Asn  Met Glu Ile Thr Ser  Glu Gln Asn Lys Gly  Ser Leu Asn 
    1925                 1930                 1935             


Asn Ile  Val Glu Gly Thr Glu  Lys Gln Ser His Ser  Gln Ser Thr 
    1940                 1945                 1950             


Ser Leu  
    1955 


<210>  287
<211>  1401
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROTOCADHERIN RELATED 15 (PCDH15), ISOFORM CRA_A 
<Accession No.: EAW54151.1>

<400>  287

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln 
    1400     


<210>  288
<211>  1783
<212>  PRT
<213>  Homo sapiens

<220>
<223>  PROTOCADHERIN RELATED 15 (PCDH15), ISOFORM X1 
<Accession No.: XP_016872062.1>

<400>  288

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu 
    1400                 1405                 1410             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1415                 1420                 1425             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1445                 1450                 1455             


Ser Ser  Met His Lys Tyr Glu  Met Pro Gln Tyr Gly  Ser Arg Arg 
    1460                 1465                 1470             


Arg Leu  Leu Pro Pro Ala Gly  Gln Glu Glu Tyr Gly  Glu Val Val 
    1475                 1480                 1485             


Gly Glu  Ala Glu Glu Glu Tyr  Glu Glu Glu Glu Glu  Glu Pro Lys 
    1490                 1495                 1500             


Lys Ile  Lys Lys Pro Lys Val  Glu Ile Arg Glu Pro  Ser Glu Glu 
    1505                 1510                 1515             


Glu Glu  Val Val Val Thr Ile  Glu Lys Pro Pro Ala  Ala Glu Pro 
    1520                 1525                 1530             


Thr Tyr  Thr Thr Trp Lys Arg  Ala Arg Ile Phe Pro  Met Ile Phe 
    1535                 1540                 1545             


Lys Lys  Val Arg Gly Leu Ala  Asp Lys Arg Gly Ile  Val Asp Leu 
    1550                 1555                 1560             


Glu Gly  Glu Glu Trp Gln Arg  Arg Leu Glu Glu Glu  Asp Lys Asp 
    1565                 1570                 1575             


Tyr Leu  Lys Leu Thr Leu Asp  Gln Glu Glu Ala Thr  Glu Ser Thr 
    1580                 1585                 1590             


Val Glu  Ser Glu Glu Glu Ser  Ser Ser Asp Tyr Thr  Glu Tyr Ser 
    1595                 1600                 1605             


Glu Glu  Glu Ser Glu Phe Ser  Glu Ser Glu Thr Thr  Glu Glu Glu 
    1610                 1615                 1620             


Ser Glu  Ser Glu Thr Pro Ser  Glu Glu Glu Glu Ser  Ser Thr Pro 
    1625                 1630                 1635             


Glu Ser  Glu Glu Ser Glu Ser  Thr Glu Ser Glu Gly  Glu Lys Ala 
    1640                 1645                 1650             


Arg Lys  Asn Ile Val Leu Ala  Arg Arg Arg Pro Met  Val Glu Glu 
    1655                 1660                 1665             


Val Lys  Glu Val Lys Gly Arg  Lys Glu Glu Pro Gln  Glu Glu Gln 
    1670                 1675                 1680             


Lys Glu  Pro Lys Met Glu Glu  Glu Glu His Ser Glu  Glu Glu Glu 
    1685                 1690                 1695             


Ser Gly  Pro Ala Pro Val Glu  Glu Ser Thr Asp Pro  Glu Ala Gln 
    1700                 1705                 1710             


Asp Ile  Pro Glu Glu Gly Ser  Ala Glu Ser Ala Ser  Val Glu Gly 
    1715                 1720                 1725             


Gly Val  Glu Ser Glu Glu Glu  Ser Glu Ser Gly Ser  Ser Ser Ser 
    1730                 1735                 1740             


Ser Ser  Glu Ser Gln Ser Gly  Gly Pro Trp Gly Tyr  Gln Val Pro 
    1745                 1750                 1755             


Ala Tyr  Asp Arg Ser Lys Asn  Ala Asn Gln Lys Lys  Ser Pro Gly 
    1760                 1765                 1770             


Ala Asn  Ser Glu Gly Tyr Asn  Thr Ala Leu 
    1775                 1780             


<210>  289
<211>  1546
<212>  PRT
<213>  Homo sapiens

<220>
<223>  USHERIN (USH2A), ISOFORM A <Accession No.: NP_009054.5>

<400>  289

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Lys Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Lys Cys  Val 
    1535                 1540                 1545     


<210>  290
<211>  5202
<212>  PRT
<213>  Homo sapiens

<220>
<223>  USHERIN (USH2A), ISOFORM B PRECURSOR  <Accession No.: 
NP_996816.2>

<400>  290

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Lys Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Thr Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  Val Tyr Gln Glu Arg  Pro Asp Asp 
    3995                 4000                 4005             


Pro Thr  Phe Asn Ser Pro Thr  Val His Ala Phe Thr  Val Lys Gly 
    4010                 4015                 4020             


Thr Ser  His Gln Ala His Leu  Tyr Gly Leu Glu Pro  Phe Thr Thr 
    4025                 4030                 4035             


Tyr Arg  Ile Gly Val Val Ala  Ala Asn His Ala Gly  Glu Ile Leu 
    4040                 4045                 4050             


Ser Pro  Trp Thr Leu Ile Gln  Thr Leu Glu Ser Ser  Pro Ser Gly 
    4055                 4060                 4065             


Leu Arg  Asn Phe Ile Val Glu  Gln Lys Glu Asn Gly  Arg Ala Leu 
    4070                 4075                 4080             


Leu Leu  Gln Trp Ser Glu Pro  Met Arg Thr Asn Gly  Val Ile Lys 
    4085                 4090                 4095             


Thr Tyr  Asn Ile Phe Ser Asp  Gly Phe Leu Glu Tyr  Ser Gly Leu 
    4100                 4105                 4110             


Asn Arg  Gln Phe Leu Phe Arg  Arg Leu Asp Pro Phe  Thr Leu Tyr 
    4115                 4120                 4125             


Thr Leu  Thr Leu Glu Ala Cys  Thr Arg Ala Gly Cys  Ala His Ser 
    4130                 4135                 4140             


Ala Pro  Gln Pro Leu Trp Thr  Asp Glu Ala Pro Pro  Asp Ser Gln 
    4145                 4150                 4155             


Leu Ala  Pro Thr Val His Ser  Val Lys Ser Thr Ser  Val Glu Leu 
    4160                 4165                 4170             


Ser Trp  Ser Glu Pro Val Asn  Pro Asn Gly Lys Ile  Ile Arg Tyr 
    4175                 4180                 4185             


Glu Val  Ile Arg Arg Cys Phe  Glu Gly Lys Ala Trp  Gly Asn Gln 
    4190                 4195                 4200             


Thr Ile  Gln Ala Asp Glu Lys  Ile Val Phe Thr Glu  Tyr Asn Thr 
    4205                 4210                 4215             


Glu Arg  Asn Thr Phe Met Tyr  Asn Asp Thr Gly Leu  Gln Pro Trp 
    4220                 4225                 4230             


Thr Gln  Cys Glu Tyr Lys Ile  Tyr Thr Trp Asn Ser  Ala Gly His 
    4235                 4240                 4245             


Thr Cys  Ser Ser Trp Asn Val  Val Arg Thr Leu Gln  Ala Pro Pro 
    4250                 4255                 4260             


Glu Gly  Leu Ser Pro Pro Val  Ile Ser Tyr Val Ser  Met Asn Pro 
    4265                 4270                 4275             


Gln Lys  Leu Leu Ile Ser Trp  Ile Pro Pro Glu Gln  Ser Asn Gly 
    4280                 4285                 4290             


Ile Ile  Gln Ser Tyr Arg Leu  Gln Arg Asn Glu Met  Leu Tyr Pro 
    4295                 4300                 4305             


Phe Ser  Phe Asp Pro Val Thr  Phe Asn Tyr Thr Asp  Glu Glu Leu 
    4310                 4315                 4320             


Leu Pro  Phe Ser Thr Tyr Ser  Tyr Ala Leu Gln Ala  Cys Thr Ser 
    4325                 4330                 4335             


Gly Gly  Cys Ser Thr Ser Lys  Pro Thr Ser Ile Thr  Thr Leu Glu 
    4340                 4345                 4350             


Ala Ala  Pro Ser Glu Val Ser  Pro Pro Asp Leu Trp  Ala Val Ser 
    4355                 4360                 4365             


Ala Thr  Gln Met Asn Val Cys  Trp Ser Pro Pro Thr  Val Gln Asn 
    4370                 4375                 4380             


Gly Lys  Ile Thr Lys Tyr Leu  Val Arg Tyr Asp Asn  Lys Glu Ser 
    4385                 4390                 4395             


Leu Ala  Gly Gln Gly Leu Cys  Leu Leu Val Ser His  Leu Gln Pro 
    4400                 4405                 4410             


Tyr Ser  Gln Tyr Asn Phe Ser  Leu Val Ala Cys Thr  Asn Gly Gly 
    4415                 4420                 4425             


Cys Thr  Ala Ser Val Ser Lys  Ser Ala Trp Thr Met  Glu Ala Leu 
    4430                 4435                 4440             


Pro Glu  Asn Met Asp Ser Pro  Thr Leu Gln Val Thr  Gly Ser Glu 
    4445                 4450                 4455             


Ser Ile  Glu Ile Thr Trp Lys  Pro Pro Arg Asn Pro  Asn Gly Gln 
    4460                 4465                 4470             


Ile Arg  Ser Tyr Glu Leu Arg  Arg Asp Gly Thr Ile  Val Tyr Thr 
    4475                 4480                 4485             


Gly Leu  Glu Thr Arg Tyr Arg  Asp Phe Thr Leu Thr  Pro Gly Val 
    4490                 4495                 4500             


Glu Tyr  Ser Tyr Thr Val Thr  Ala Ser Asn Ser Gln  Gly Gly Ile 
    4505                 4510                 4515             


Leu Ser  Pro Leu Val Lys Asp  Arg Thr Ser Pro Ser  Ala Pro Ser 
    4520                 4525                 4530             


Gly Met  Glu Pro Pro Lys Leu  Gln Ala Arg Gly Pro  Gln Glu Ile 
    4535                 4540                 4545             


Leu Val  Asn Trp Asp Pro Pro  Val Arg Thr Asn Gly  Asp Ile Ile 
    4550                 4555                 4560             


Asn Tyr  Thr Leu Phe Ile Arg  Glu Leu Phe Glu Arg  Glu Thr Lys 
    4565                 4570                 4575             


Ile Ile  His Ile Asn Thr Thr  His Asn Ser Phe Gly  Met Gln Ser 
    4580                 4585                 4590             


Tyr Ile  Val Asn Gln Leu Lys  Pro Phe His Arg Tyr  Glu Ile Arg 
    4595                 4600                 4605             


Ile Gln  Ala Cys Thr Thr Leu  Gly Cys Ala Ser Ser  Asp Trp Thr 
    4610                 4615                 4620             


Phe Ile  Gln Thr Pro Glu Ile  Ala Pro Leu Met Gln  Pro Pro Pro 
    4625                 4630                 4635             


His Leu  Glu Val Gln Met Ala  Pro Gly Gly Phe Gln  Pro Thr Val 
    4640                 4645                 4650             


Ser Leu  Leu Trp Thr Gly Pro  Leu Gln Pro Asn Gly  Lys Val Leu 
    4655                 4660                 4665             


Tyr Tyr  Glu Leu Tyr Arg Arg  Gln Ile Ala Thr Gln  Pro Arg Lys 
    4670                 4675                 4680             


Ser Asn  Pro Val Leu Ile Tyr  Asn Gly Ser Ser Thr  Ser Phe Ile 
    4685                 4690                 4695             


Asp Ser  Glu Leu Leu Pro Phe  Thr Glu Tyr Glu Tyr  Gln Val Trp 
    4700                 4705                 4710             


Ala Val  Asn Ser Ala Gly Lys  Ala Pro Ser Ser Trp  Thr Trp Cys 
    4715                 4720                 4725             


Arg Thr  Gly Pro Ala Pro Pro  Glu Gly Leu Arg Ala  Pro Thr Phe 
    4730                 4735                 4740             


His Val  Ile Ser Ser Thr Gln  Ala Val Val Asn Ile  Ser Ala Pro 
    4745                 4750                 4755             


Gly Lys  Pro Asn Gly Ile Val  Ser Leu Tyr Arg Leu  Phe Ser Ser 
    4760                 4765                 4770             


Ser Ala  His Gly Ala Glu Thr  Val Leu Ser Glu Gly  Met Ala Thr 
    4775                 4780                 4785             


Gln Gln  Thr Leu His Gly Leu  Gln Ala Phe Thr Asn  Tyr Ser Ile 
    4790                 4795                 4800             


Gly Val  Glu Ala Cys Thr Cys  Phe Asn Cys Cys Ser  Lys Gly Pro 
    4805                 4810                 4815             


Thr Ala  Glu Leu Arg Thr His  Pro Ala Pro Pro Ser  Gly Leu Ser 
    4820                 4825                 4830             


Ser Pro  Gln Ile Gly Thr Leu  Ala Ser Arg Thr Ala  Ser Phe Arg 
    4835                 4840                 4845             


Trp Ser  Pro Pro Met Phe Pro  Asn Gly Val Ile His  Ser Tyr Glu 
    4850                 4855                 4860             


Leu Gln  Phe His Val Ala Cys  Pro Pro Asp Ser Ala  Leu Pro Cys 
    4865                 4870                 4875             


Thr Pro  Ser Gln Ile Glu Thr  Lys Tyr Thr Gly Leu  Gly Gln Lys 
    4880                 4885                 4890             


Ala Ser  Leu Gly Gly Leu Gln  Pro Tyr Thr Thr Tyr  Lys Leu Arg 
    4895                 4900                 4905             


Val Val  Ala His Asn Glu Val  Gly Ser Thr Ala Ser  Glu Trp Ile 
    4910                 4915                 4920             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    4925                 4930                 4935             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    4940                 4945                 4950             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    4955                 4960                 4965             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    4970                 4975                 4980             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    4985                 4990                 4995             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    5000                 5005                 5010             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    5015                 5020                 5025             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    5030                 5035                 5040             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    5045                 5050                 5055             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    5060                 5065                 5070             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    5075                 5080                 5085             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    5090                 5095                 5100             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    5105                 5110                 5115             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    5120                 5125                 5130             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    5135                 5140                 5145             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    5150                 5155                 5160             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    5165                 5170                 5175             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    5180                 5185                 5190             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    5195                 5200         


<210>  291
<211>  1546
<212>  PRT
<213>  Homo sapiens

<220>
<223>  USHERIN (USH2A), TYPE IIA  <Accession No.: AAC23748.2>

<400>  291

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Ser Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Lys Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Lys Cys  Val 
    1535                 1540                 1545     


<210>  292
<211>  232
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CLARIN 1 (CLRN1) <Accession No.: AAH74971.1>

<400>  292

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys 
145                 150                 155                 160 


Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr 
                165                 170                 175     


Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile 
            180                 185                 190         


Phe Phe Cys Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu 
        195                 200                 205             


Ala Gly Phe Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr 
    210                 215                 220                 


Asn Val Ala Ala Asp Leu Met Tyr 
225                 230         


<210>  293
<211>  232
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CLARIN 1 (CLRN1), ISOFORM A <Accession No.: NP_777367.1>

<400>  293

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys 
145                 150                 155                 160 


Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr 
                165                 170                 175     


Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile 
            180                 185                 190         


Phe Phe Cys Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu 
        195                 200                 205             


Ala Gly Phe Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr 
    210                 215                 220                 


Asn Val Ala Ala Asp Leu Met Tyr 
225                 230         


<210>  294
<211>  245
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CLARIN 1 (CLRN1), ISOFORM D <Accession No.: NP_001182723.1>

<400>  294

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Val Ala Leu Trp Leu Pro Ala Thr Arg His Gln Ala Gln Gly Ser Cys 
145                 150                 155                 160 


Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys Ile His His 
                165                 170                 175     


Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr Val Tyr Lys 
            180                 185                 190         


Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile Phe Phe Cys 
        195                 200                 205             


Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu Ala Gly Phe 
    210                 215                 220                 


Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr Asn Val Ala 
225                 230                 235                 240 


Ala Asp Leu Met Tyr 
                245 


<210>  295
<211>  120
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CLARIN 1 (CLRN1), ISOFORM C <Accession No.: NP_443721.1>

<400>  295

Met Gln Ala Leu Gln Gln Gln Pro Val Phe Pro Asp Leu Leu Lys Ala 
1               5                   10                  15      


Ile Pro Val Ser Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu 
            20                  25                  30          


Ile Val Leu Thr Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe 
        35                  40                  45              


Gly Lys Pro Phe Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu 
    50                  55                  60                  


Ser Phe Ile Ser Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala 
65                  70                  75                  80  


Ser Glu Val Lys Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys 
                85                  90                  95      


Glu Gly Thr Tyr Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser 
            100                 105                 110         


Phe Trp Leu Thr Lys Gly His Ser 
        115                 120 


<210>  296
<211>  185
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CLARIN 1 (CLRN1), ISOFORM E <Accession No.: NP_001243748.1>

<400>  296

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Cys Tyr Phe Leu Asp Pro Phe Met Gly Leu Pro Thr 
                85                  90                  95      


Gly Val Pro His Leu Leu Ser Leu Pro Cys Ser Thr Ser Cys Arg Arg 
            100                 105                 110         


Glu His Thr Ser Glu Arg Val Gln Glu Pro Ala Gly Cys Phe Ser Ala 
        115                 120                 125             


Val Arg Ser Lys Leu His Ala Gly Pro Ala Ala Ala Thr Ser Phe Ser 
    130                 135                 140                 


Arg Phe Ala Gln Ser Asn Pro Ser Glu His Pro Arg Gln Cys His Ser 
145                 150                 155                 160 


Leu Leu Cys His Pro Tyr Cys Val Asn His Gly Gly Asp Ser Leu Leu 
                165                 170                 175     


His Val Gln Cys Phe Trp Lys Thr Phe 
            180                 185 


<210>  297
<211>  2273
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ATP BINDING CASSETTE SUBFAMILY A MEMBER 4 (ABCA4) 
<Accession No.: P78363.3>

<400>  297

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  298
<211>  2273
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ATP BINDING CASSETTE SUBFAMILY A MEMBER 4 (ABCA4), 
ISOFORM CRA_A <Accession No.: EAW73056.1>

<400>  298

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  299
<211>  1203
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ATP BINDING CASSETTE SUBFAMILY A MEMBER 4 (ABCA4), 
ISOFORM CRA_B <Accession No.: EAW73057.1>

<400>  299

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Val  Val Ile Pro Ser Ile  Cys Cys Arg Gly Pro  Ala Ala Ala 
    1175                 1180                 1185             


Arg Leu  Arg Val Ser Pro Pro  Arg Val Gln Pro Thr  Ser Met Thr 
    1190                 1195                 1200             


<210>  300
<211>  2256
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ATP BINDING CASSETTE SUBFAMILY A MEMBER 4 (ABCA4), 
ISOFORM CRA_C <Accession No.: EAW73058.1>

<400>  300

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Arg Gln  Glu Ile Pro 
    2120                 2125                 2130             


Arg Ala  Gly Glu Glu Cys Glu  Ala Leu Cys Thr Arg  Leu Ala Ile 
    2135                 2140                 2145             


Met Val  Lys Gly Ala Phe Arg  Cys Met Gly Thr Ile  Gln His Leu 
    2150                 2155                 2160             


Lys Ser  Lys Phe Gly Asp Gly  Tyr Ile Val Thr Met  Lys Ile Lys 
    2165                 2170                 2175             


Ser Pro  Lys Asp Asp Leu Leu  Pro Asp Leu Asn Pro  Val Glu Gln 
    2180                 2185                 2190             


Phe Phe  Gln Gly Asn Phe Pro  Gly Ser Val Gln Arg  Glu Arg His 
    2195                 2200                 2205             


Tyr Asn  Met Leu Gln Phe Gln  Val Ser Ser Ser Ser  Leu Ala Arg 
    2210                 2215                 2220             


Ile Phe  Gln Leu Leu Leu Ser  His Lys Asp Ser Leu  Leu Ile Glu 
    2225                 2230                 2235             


Glu Tyr  Ser Val Thr Gln Thr  Thr Leu Asp Gln Ala  Ser Val Cys 
    2240                 2245                 2250             


Lys Phe  Cys 
    2255     


<210>  301
<211>  314
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ELOVL FATTY ACID ELONGASE 4 (ELOVL4) <Accession 
No.: NP_073563.1>

<400>  301

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Leu Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Ala Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Met Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  302
<211>  212
<212>  PRT
<213>  Homo sapiens

<220>
<223>  INTERLEUKIN 6 (IL6)  <Accession No.: AAC41704.1>

<400>  302

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  303
<211>  233
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TNF-ALPHA (TNF)  <Accession No.: CAA26669.1>

<400>  303

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  304
<211>  364
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L OPSIN (OPN1LW) <Accession No.: NP_064445.2>

<400>  304

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Thr Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 
            100                 105                 110         


Asn Gln Val Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  305
<211>  364
<212>  PRT
<213>  Homo sapiens

<220>
<223>  M OPSIN (OPN1MW) <Accession No.: NP_000504.1>

<400>  305

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Ile Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val Val 
            100                 105                 110         


Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Val Leu Ala Phe Cys Phe Cys Trp Gly Pro Tyr Ala Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  306
<211>  1103
<212>  PRT
<213>  Homo sapiens

<220>
<223>  GUANYLATE CYCLASE 2D, RETINAL (GUCY2D) <Accession No.: 
Q02846.2>

<400>  306

Met Thr Ala Cys Ala Arg Arg Ala Gly Gly Leu Pro Asp Pro Gly Leu 
1               5                   10                  15      


Cys Gly Pro Ala Trp Trp Ala Pro Ser Leu Pro Arg Leu Pro Arg Ala 
            20                  25                  30          


Leu Pro Arg Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro 
        35                  40                  45              


Ala Leu Ser Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys 
    50                  55                  60                  


Asp Pro Ile Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Ala Arg Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe 
                85                  90                  95      


Glu Val Ala Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly 
            100                 105                 110         


Ala Val Ser Ser Ala Leu Ala Arg Val Ser Gly Leu Val Gly Pro Val 
        115                 120                 125             


Asn Pro Ala Ala Cys Arg Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly 
    130                 135                 140                 


Ile Ala Leu Val Pro Trp Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr 
145                 150                 155                 160 


Thr Ala Pro Ala Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu 
                165                 170                 175     


Arg Ala Phe Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp 
            180                 185                 190         


Leu Trp Val Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg 
        195                 200                 205             


Gly Leu Pro Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu Ser 
    210                 215                 220                 


Gly Ala Arg Glu Ala Leu Arg Lys Val Arg Asp Gly Pro Arg Val Thr 
225                 230                 235                 240 


Ala Val Ile Met Val Met His Ser Val Leu Leu Gly Gly Glu Glu Gln 
                245                 250                 255     


Arg Tyr Leu Leu Glu Ala Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser 
            260                 265                 270         


Leu Val Phe Leu Pro Phe Asp Thr Ile His Tyr Ala Leu Ser Pro Gly 
        275                 280                 285             


Pro Glu Ala Leu Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala 
    290                 295                 300                 


His Asp Ala Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser 
305                 310                 315                 320 


Val Leu Asp Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser 
                325                 330                 335     


Asp Leu Asn Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp 
            340                 345                 350         


Ala Val Phe Leu Leu Ala Arg Gly Val Ala Glu Ala Arg Ala Ala Ala 
        355                 360                 365             


Gly Gly Arg Trp Val Ser Gly Ala Ala Val Ala Arg His Ile Arg Asp 
    370                 375                 380                 


Ala Gln Val Pro Gly Phe Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro 
385                 390                 395                 400 


Pro Phe Val Leu Leu Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala 
                405                 410                 415     


Thr Tyr Met Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr 
            420                 425                 430         


Arg Met His Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser 
        435                 440                 445             


Cys Trp Phe Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly 
    450                 455                 460                 


Leu Val Phe Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu Ala Gly 
465                 470                 475                 480 


Ala Phe Leu Ala His Tyr Val Arg His Arg Leu Leu His Met Gln Met 
                485                 490                 495     


Val Ser Gly Pro Asn Lys Ile Ile Leu Thr Val Asp Asp Ile Thr Phe 
            500                 505                 510         


Leu His Pro His Gly Gly Thr Ser Arg Lys Val Ala Gln Gly Ser Arg 
        515                 520                 525             


Ser Ser Leu Gly Ala Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser 
    530                 535                 540                 


Gln His Leu Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val 
545                 550                 555                 560 


Trp Leu Lys Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala 
                565                 570                 575     


Thr Lys Thr Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn Val 
            580                 585                 590         


Ala Leu Tyr Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala 
        595                 600                 605             


Ala Leu Trp Glu Gly Asn Leu Ala Val Val Ser Glu His Cys Thr Arg 
    610                 615                 620                 


Gly Ser Leu Gln Asp Leu Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp 
625                 630                 635                 640 


Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr 
                645                 650                 655     


Leu His His Arg Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys 
            660                 665                 670         


Ile Val Asp Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly 
        675                 680                 685             


Arg Leu Leu Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu 
    690                 695                 700                 


Asp Gln Leu Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu 
705                 710                 715                 720 


Arg Arg Gly Thr Leu Ala Gly Asp Val Phe Ser Leu Ala Ile Ile Met 
                725                 730                 735     


Gln Glu Val Val Cys Arg Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr 
            740                 745                 750         


Pro Glu Glu Val Val Gln Arg Val Arg Ser Pro Pro Pro Leu Cys Arg 
        755                 760                 765             


Pro Leu Val Ser Met Asp Gln Ala Pro Val Glu Cys Ile Leu Leu Met 
    770                 775                 780                 


Lys Gln Cys Trp Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His 
785                 790                 795                 800 


Thr Phe Asp Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile 
                805                 810                 815     


Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu 
            820                 825                 830         


Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys 
        835                 840                 845             


Thr Asp Arg Leu Leu Thr Gln Met Leu Pro Pro Ser Val Ala Glu Ala 
    850                 855                 860                 


Leu Lys Thr Gly Thr Pro Val Glu Pro Glu Tyr Phe Glu Gln Val Thr 
865                 870                 875                 880 


Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Ser Ala Met Ser 
                885                 890                 895     


Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe 
            900                 905                 910         


Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly 
        915                 920                 925             


Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg 
    930                 935                 940                 


His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val 
945                 950                 955                 960 


Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val Arg Ile Arg 
                965                 970                 975     


Ile Gly Leu His Ser Gly Pro Cys Val Ala Gly Val Val Gly Leu Thr 
            980                 985                 990         


Met Pro Arg Tyr Cys Leu Phe Gly  Asp Thr Val Asn Thr  Ala Ser Arg 
        995                 1000                 1005             


Met Glu  Ser Thr Gly Leu Pro  Tyr Arg Ile His Val  Asn Leu Ser 
    1010                 1015                 1020             


Thr Val  Gly Ile Leu Arg Ala  Leu Asp Ser Gly Tyr  Gln Val Glu 
    1025                 1030                 1035             


Leu Arg  Gly Arg Thr Glu Leu  Lys Gly Lys Gly Ala  Glu Asp Thr 
    1040                 1045                 1050             


Phe Trp  Leu Val Gly Arg Arg  Gly Phe Asn Lys Pro  Ile Pro Lys 
    1055                 1060                 1065             


Pro Pro  Asp Leu Gln Pro Gly  Ser Ser Asn His Gly  Ile Ser Leu 
    1070                 1075                 1080             


Gln Glu  Ile Pro Pro Glu Arg  Arg Arg Lys Leu Glu  Lys Ala Arg 
    1085                 1090                 1095             


Pro Gly  Gln Phe Ser 
    1100             


<210>  307
<211>  533
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOID ISOMEROHYDROLASE RPE65 (RPE65) <Accession 
No.: NP_000320.1>

<400>  307

Met Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe 
1               5                   10                  15      


Glu Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly 
            20                  25                  30          


Arg Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 
        35                  40                  45              


Leu Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 
    50                  55                  60                  


Ala Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 
65                  70                  75                  80  


Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 
                85                  90                  95      


Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys 
            100                 105                 110         


Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val 
        115                 120                 125             


Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr 
    130                 135                 140                 


Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 
                165                 170                 175     


Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 
            180                 185                 190         


Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 
        195                 200                 205             


Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 
    210                 215                 220                 


Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val 
225                 230                 235                 240 


His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro 
                245                 250                 255     


Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly 
            260                 265                 270         


Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp 
        275                 280                 285             


Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 
305                 310                 315                 320 


Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 
                325                 330                 335     


Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu 
            340                 345                 350         


Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr 
        355                 360                 365             


Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val 
    370                 375                 380                 


Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr 
385                 390                 395                 400 


Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe 
                405                 410                 415     


Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 
            420                 425                 430         


Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 
        435                 440                 445             


Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 
    450                 455                 460                 


Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu 
465                 470                 475                 480 


Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly 
                485                 490                 495     


Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu 
            500                 505                 510         


Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly 
        515                 520                 525             


Leu Phe Lys Lys Ser 
    530             


<210>  308
<211>  441
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RETINOID ISOMEROHYDROLASE RPE65 (RPE65), ISOFORM X1 
<Accession No.: XP_016857516.1>

<400>  308

Met Thr Glu Lys Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe 
1               5                   10                  15      


Pro Asp Pro Cys Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg 
            20                  25                  30          


Gly Val Glu Val Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly 
        35                  40                  45              


Glu Asp Tyr Tyr Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn 
    50                  55                  60                  


Pro Glu Thr Leu Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val 
65                  70                  75                  80  


Ser Val Asn Gly Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr 
                85                  90                  95      


Val Tyr Asn Ile Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr 
            100                 105                 110         


Asn Ile Val Lys Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile 
        115                 120                 125             


Ser Lys Ser Glu Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys 
    130                 135                 140                 


Pro Ser Tyr Val His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe 
145                 150                 155                 160 


Val Glu Thr Pro Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp 
                165                 170                 175     


Ser Leu Trp Gly Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr 
            180                 185                 190         


Met Gly Val Trp Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu 
        195                 200                 205             


Asn Asn Lys Tyr Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn 
    210                 215                 220                 


Thr Tyr Glu Asp Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys 
225                 230                 235                 240 


Gly Phe Glu Phe Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu 
                245                 250                 255     


Asn Trp Glu Glu Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu 
            260                 265                 270         


Val Arg Arg Tyr Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly 
        275                 280                 285             


Lys Asn Leu Val Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys 
    290                 295                 300                 


Ser Asp Glu Thr Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro 
305                 310                 315                 320 


Arg Gln Ala Phe Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly 
                325                 330                 335     


Lys Pro Tyr Thr Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro 
            340                 345                 350         


Asp Arg Leu Cys Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp 
        355                 360                 365             


Gln Glu Pro Asp Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro 
    370                 375                 380                 


Asp Ala Leu Glu Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser 
385                 390                 395                 400 


Pro Gly Ala Gly Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys 
                405                 410                 415     


Asp Leu Ser Glu Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val 
            420                 425                 430         


Thr Phe His Gly Leu Phe Lys Lys Ser 
        435                 440     


<210>  309
<211>  360
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN LIKE 1 
(AIPL1) <Accession No.: CAH25996.1>

<400>  309

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile His Thr Gly Val 
                85                  90                  95      


Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala Gln Gly Lys Asp 
            100                 105                 110         


Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala Asn Met Phe Ala 
        115                 120                 125             


Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro 
    130                 135                 140                 


Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val Asp Ala Pro Ser 
145                 150                 155                 160 


Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys 
                165                 170                 175     


Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly 
            180                 185                 190         


Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu 
        195                 200                 205             


Arg Asn Leu Gln Thr Lys Cys Leu Leu Lys Lys Glu Glu Tyr Tyr Glu 
    210                 215                 220                 


Val Leu Glu His Thr Ser Asp Ile Leu Arg His His Pro Gly Ile Val 
225                 230                 235                 240 


Lys Ala Tyr Tyr Val Arg Ala Arg Ala His Ala Glu Val Trp Asn Glu 
                245                 250                 255     


Ala Glu Ala Lys Ala Asp Leu Gln Lys Val Leu Glu Leu Glu Pro Ser 
            260                 265                 270         


Met Gln Lys Ala Val Arg Arg Glu Leu Arg Leu Leu Glu Asn Arg Met 
        275                 280                 285             


Ala Glu Lys Gln Glu Glu Glu Arg Leu Arg Cys Arg Asn Met Leu Ser 
    290                 295                 300                 


Gln Gly Ala Thr Gln Pro Pro Ala Glu Pro Pro Thr Glu Pro Pro Ala 
305                 310                 315                 320 


Gln Ser Ser Thr Glu Pro Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala 
                325                 330                 335     


Glu Leu Ser Ala Gly Pro Pro Ala Glu Pro Ala Thr Glu Pro Pro Pro 
            340                 345                 350         


Ser Pro Gly His Ser Leu Gln His 
        355                 360 


<210>  310
<211>  362
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN LIKE 1 
(AIPL1) <Accession No.: CAH25995.1>

<400>  310

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Gly Gln Pro Met His Ile Ile Ile Gly Asn Met Phe Lys Leu Glu 
        35                  40                  45              


Val Trp Glu Ile Leu Leu Thr Ser Met Arg Val His Glu Val Ala Glu 
    50                  55                  60                  


Phe Trp Cys Asp Thr Ile His Thr Gly Val Tyr Pro Ile Leu Ser Arg 
65                  70                  75                  80  


Ser Leu Arg Gln Met Ala Gln Gly Lys Asp Pro Thr Glu Trp His Val 
                85                  90                  95      


His Thr Cys Gly Leu Ala Asn Met Phe Ala Tyr His Thr Leu Gly Tyr 
            100                 105                 110         


Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro Gln Pro Leu Val Phe Val 
        115                 120                 125             


Ile Glu Leu Leu Gln Val Asp Ala Pro Ser Asp Tyr Gln Arg Glu Thr 
    130                 135                 140                 


Trp Asn Leu Ser Asn His Glu Lys Met Lys Ala Val Pro Val Leu His 
145                 150                 155                 160 


Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly Arg Tyr Glu Glu Ala Ser 
                165                 170                 175     


Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu Arg Asn Leu Gln Thr Lys 
            180                 185                 190         


Glu Lys Pro Trp Glu Val Gln Trp Leu Lys Leu Glu Lys Met Ile Asn 
        195                 200                 205             


Thr Leu Ile Leu Asn Tyr Cys Gln Cys Leu Leu Lys Lys Glu Glu Tyr 
    210                 215                 220                 


Tyr Glu Val Leu Glu His Thr Ser Asp Ile Leu Arg His His Pro Gly 
225                 230                 235                 240 


Ile Val Lys Ala Tyr Tyr Val Arg Ala Arg Ala His Ala Glu Val Trp 
                245                 250                 255     


Asn Glu Ala Glu Ala Lys Ala Asp Leu Gln Lys Val Leu Glu Leu Glu 
            260                 265                 270         


Pro Ser Met Gln Lys Ala Val Arg Arg Glu Leu Arg Leu Leu Glu Asn 
        275                 280                 285             


Arg Met Ala Glu Lys Gln Glu Glu Glu Arg Leu Arg Cys Arg Asn Met 
    290                 295                 300                 


Leu Ser Gln Gly Ala Thr Gln Pro Pro Ala Glu Pro Pro Thr Glu Pro 
305                 310                 315                 320 


Pro Ala Gln Ser Ser Thr Glu Pro Pro Ala Glu Pro Pro Thr Ala Pro 
                325                 330                 335     


Ser Ala Glu Leu Ser Ala Gly Pro Pro Ala Glu Pro Ala Thr Glu Pro 
            340                 345                 350         


Pro Pro Ser Pro Gly His Ser Leu Gln His 
        355                 360         


<210>  311
<211>  321
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN LIKE 1
 (AIPL1) <Accession No.: CAG17883.1>

<400>  311

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys His Thr Ile Val Asp Ala Pro 
                85                  90                  95      


Ser Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met 
            100                 105                 110         


Lys Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu 
        115                 120                 125             


Gly Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys 
    130                 135                 140                 


Leu Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu 
145                 150                 155                 160 


Lys Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys 
                165                 170                 175     


Leu Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp 
            180                 185                 190         


Ile Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Val Arg Ala 
        195                 200                 205             


Arg Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu 
    210                 215                 220                 


Gln Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg 
225                 230                 235                 240 


Glu Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu 
                245                 250                 255     


Arg Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro 
            260                 265                 270         


Ala Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu Pro Pro 
        275                 280                 285             


Ala Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro 
    290                 295                 300                 


Ala Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln 
305                 310                 315                 320 


His 
    


<210>  312
<211>  324
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN LIKE 1 
(AIPL1) <Accession No.: CAG17882.1>

<400>  312

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


His Thr Gly Val Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala 
        35                  40                  45              


Gln Gly Lys Asp Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala 
    50                  55                  60                  


Asn Met Phe Ala Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu 
65                  70                  75                  80  


Gln Lys Glu Pro Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val 
                85                  90                  95      


Asp Ala Pro Ser Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His 
            100                 105                 110         


Glu Lys Met Lys Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu 
        115                 120                 125             


Phe Lys Leu Gly Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala 
    130                 135                 140                 


Ile Ile Cys Leu Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val 
145                 150                 155                 160 


Gln Trp Leu Lys Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr 
                165                 170                 175     


Cys Gln Cys Leu Leu Lys Lys Lys Glu Tyr Tyr Glu Val Leu Glu His 
            180                 185                 190         


Thr Ser Asp Ile Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr 
        195                 200                 205             


Val Arg Ala Arg Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys 
    210                 215                 220                 


Ala Asp Leu Gln Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala 
225                 230                 235                 240 


Val Arg Arg Glu Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln 
                245                 250                 255     


Glu Glu Glu Arg Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr 
            260                 265                 270         


Gln Pro Pro Ala Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr 
        275                 280                 285             


Glu Pro Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala 
    290                 295                 300                 


Gly Pro Pro Ala Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His 
305                 310                 315                 320 


Ser Leu Gln His 
                


<210>  313
<211>  384
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN LIKE 1 
(AIPL1) <Accession No.: AAH12055.1>

<400>  313

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile His Thr Gly Val 
                85                  90                  95      


Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala Gln Gly Lys Asp 
            100                 105                 110         


Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala Asn Met Phe Ala 
        115                 120                 125             


Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro 
    130                 135                 140                 


Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val Asp Ala Pro Ser 
145                 150                 155                 160 


Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys 
                165                 170                 175     


Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly 
            180                 185                 190         


Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu 
        195                 200                 205             


Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu Lys 
    210                 215                 220                 


Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys Leu 
225                 230                 235                 240 


Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp Ile 
                245                 250                 255     


Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Val Arg Ala Arg 
            260                 265                 270         


Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg Glu 
    290                 295                 300                 


Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu Arg 
305                 310                 315                 320 


Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro Ala 
                325                 330                 335     


Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu Pro Pro Ala 
            340                 345                 350         


Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro Ala 
        355                 360                 365             


Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln His 
    370                 375                 380                 


<210>  314
<211>  1676
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C5B isoform 1 <Accession No.: NP_001726.2>

<400>  314

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  315
<211>  1682
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C5B, isoform 2 <Accession No.: NP_001304092.1>

<400>  315

Met Pro Gly Ser Leu Gly Arg Glu Ala Ser Gly Arg Ala Gly Pro Thr 
1               5                   10                  15      


Gly Cys Gly Ala Phe Ala Phe Gly Leu Arg Cys Arg Tyr Val Ile Ser 
            20                  25                  30          


Ala Pro Lys Ile Phe Arg Val Gly Ala Ser Glu Asn Ile Val Ile Gln 
        35                  40                  45              


Val Tyr Gly Tyr Thr Glu Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser 
    50                  55                  60                  


Tyr Pro Asp Lys Lys Phe Ser Tyr Ser Ser Gly His Val His Leu Ser 
65                  70                  75                  80  


Ser Glu Asn Lys Phe Gln Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys 
                85                  90                  95      


Gln Leu Pro Gly Gly Gln Asn Pro Val Ser Tyr Val Tyr Leu Glu Val 
            100                 105                 110         


Val Ser Lys His Phe Ser Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp 
        115                 120                 125             


Asn Gly Phe Leu Phe Ile His Thr Asp Lys Pro Val Tyr Thr Pro Asp 
    130                 135                 140                 


Gln Ser Val Lys Val Arg Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro 
145                 150                 155                 160 


Ala Lys Arg Glu Thr Val Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu 
                165                 170                 175     


Val Asp Met Val Glu Glu Ile Asp His Ile Gly Ile Ile Ser Phe Pro 
            180                 185                 190         


Asp Phe Lys Ile Pro Ser Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys 
        195                 200                 205             


Ala Lys Tyr Lys Glu Asp Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu 
    210                 215                 220                 


Val Lys Glu Tyr Val Leu Pro His Phe Ser Val Ser Ile Glu Pro Glu 
225                 230                 235                 240 


Tyr Asn Phe Ile Gly Tyr Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile 
                245                 250                 255     


Lys Ala Arg Tyr Phe Tyr Asn Lys Val Val Thr Glu Ala Asp Val Tyr 
            260                 265                 270         


Ile Thr Phe Gly Ile Arg Glu Asp Leu Lys Asp Asp Gln Lys Glu Met 
        275                 280                 285             


Met Gln Thr Ala Met Gln Asn Thr Met Leu Ile Asn Gly Ile Ala Gln 
    290                 295                 300                 


Val Thr Phe Asp Ser Glu Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser 
305                 310                 315                 320 


Leu Glu Asp Leu Asn Asn Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile 
                325                 330                 335     


Glu Ser Thr Gly Gly Phe Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys 
            340                 345                 350         


Tyr Val Leu Ser Pro Tyr Lys Leu Asn Leu Val Ala Thr Pro Leu Phe 
        355                 360                 365             


Leu Lys Pro Gly Ile Pro Tyr Pro Ile Lys Val Gln Val Lys Asp Ser 
    370                 375                 380                 


Leu Asp Gln Leu Val Gly Gly Val Pro Val Thr Leu Asn Ala Gln Thr 
385                 390                 395                 400 


Ile Asp Val Asn Gln Glu Thr Ser Asp Leu Asp Pro Ser Lys Ser Val 
                405                 410                 415     


Thr Arg Val Asp Asp Gly Val Ala Ser Phe Val Leu Asn Leu Pro Ser 
            420                 425                 430         


Gly Val Thr Val Leu Glu Phe Asn Val Lys Thr Asp Ala Pro Asp Leu 
        435                 440                 445             


Pro Glu Glu Asn Gln Ala Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser 
    450                 455                 460                 


Ser Leu Ser Gln Ser Tyr Leu Tyr Ile Asp Trp Thr Asp Asn His Lys 
465                 470                 475                 480 


Ala Leu Leu Val Gly Glu His Leu Asn Ile Ile Val Thr Pro Lys Ser 
                485                 490                 495     


Pro Tyr Ile Asp Lys Ile Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys 
            500                 505                 510         


Gly Lys Ile Ile His Phe Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser 
        515                 520                 525             


Tyr Gln Ser Ile Asn Ile Pro Val Thr Gln Asn Met Val Pro Ser Ser 
    530                 535                 540                 


Arg Leu Leu Val Tyr Tyr Ile Val Thr Gly Glu Gln Thr Ala Glu Leu 
545                 550                 555                 560 


Val Ser Asp Ser Val Trp Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln 
                565                 570                 575     


Leu Gln Val His Leu Ser Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln 
            580                 585                 590         


Thr Val Ser Leu Asn Met Ala Thr Gly Met Asp Ser Trp Val Ala Leu 
        595                 600                 605             


Ala Ala Val Asp Ser Ala Val Tyr Gly Val Gln Arg Gly Ala Lys Lys 
    610                 615                 620                 


Pro Leu Glu Arg Val Phe Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys 
625                 630                 635                 640 


Gly Ala Gly Gly Gly Leu Asn Asn Ala Asn Val Phe His Leu Ala Gly 
                645                 650                 655     


Leu Thr Phe Leu Thr Asn Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp 
            660                 665                 670         


Glu Pro Cys Lys Glu Ile Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys 
        675                 680                 685             


Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser Val Val Lys Lys Cys 
    690                 695                 700                 


Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
705                 710                 715                 720 


Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu 
                725                 730                 735     


Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn Ile Ser His Lys Asp 
            740                 745                 750         


Met Gln Leu Gly Arg Leu His Met Lys Thr Leu Leu Pro Val Ser Lys 
        755                 760                 765             


Pro Glu Ile Arg Ser Tyr Phe Pro Glu Ser Trp Leu Trp Glu Val His 
    770                 775                 780                 


Leu Val Pro Arg Arg Lys Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu 
785                 790                 795                 800 


Thr Thr Trp Glu Ile Gln Gly Val Gly Ile Ser Asn Thr Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Thr Val Lys Ala Lys Val Phe Lys Asp Val Phe Leu Glu 
            820                 825                 830         


Met Asn Ile Pro Tyr Ser Val Val Arg Gly Glu Gln Ile Gln Leu Lys 
        835                 840                 845             


Gly Thr Val Tyr Asn Tyr Arg Thr Ser Gly Met Gln Phe Cys Val Lys 
    850                 855                 860                 


Met Ser Ala Val Glu Gly Ile Cys Thr Ser Glu Ser Pro Val Ile Asp 
865                 870                 875                 880 


His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg Gln Lys Val Glu Gly 
                885                 890                 895     


Ser Ser Ser His Leu Val Thr Phe Thr Val Leu Pro Leu Glu Ile Gly 
            900                 905                 910         


Leu His Asn Ile Asn Phe Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile 
        915                 920                 925             


Leu Val Lys Thr Leu Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser 
    930                 935                 940                 


Tyr Ser Gly Val Thr Leu Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser 
945                 950                 955                 960 


Arg Arg Lys Glu Phe Pro Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys 
                965                 970                 975     


Thr Glu Ile Lys Arg Ile Leu Ser Val Lys Gly Leu Leu Val Gly Glu 
            980                 985                 990         


Ile Leu Ser Ala Val Leu Ser Gln  Glu Gly Ile Asn Ile  Leu Thr His 
        995                 1000                 1005             


Leu Pro  Lys Gly Ser Ala Glu  Ala Glu Leu Met Ser  Val Val Pro 
    1010                 1015                 1020             


Val Phe  Tyr Val Phe His Tyr  Leu Glu Thr Gly Asn  His Trp Asn 
    1025                 1030                 1035             


Ile Phe  His Ser Asp Pro Leu  Ile Glu Lys Gln Lys  Leu Lys Lys 
    1040                 1045                 1050             


Lys Leu  Lys Glu Gly Met Leu  Ser Ile Met Ser Tyr  Arg Asn Ala 
    1055                 1060                 1065             


Asp Tyr  Ser Tyr Ser Val Trp  Lys Gly Gly Ser Ala  Ser Thr Trp 
    1070                 1075                 1080             


Leu Thr  Ala Phe Ala Leu Arg  Val Leu Gly Gln Val  Asn Lys Tyr 
    1085                 1090                 1095             


Val Glu  Gln Asn Gln Asn Ser  Ile Cys Asn Ser Leu  Leu Trp Leu 
    1100                 1105                 1110             


Val Glu  Asn Tyr Gln Leu Asp  Asn Gly Ser Phe Lys  Glu Asn Ser 
    1115                 1120                 1125             


Gln Tyr  Gln Pro Ile Lys Leu  Gln Gly Thr Leu Pro  Val Glu Ala 
    1130                 1135                 1140             


Arg Glu  Asn Ser Leu Tyr Leu  Thr Ala Phe Thr Val  Ile Gly Ile 
    1145                 1150                 1155             


Arg Lys  Ala Phe Asp Ile Cys  Pro Leu Val Lys Ile  Asp Thr Ala 
    1160                 1165                 1170             


Leu Ile  Lys Ala Asp Asn Phe  Leu Leu Glu Asn Thr  Leu Pro Ala 
    1175                 1180                 1185             


Gln Ser  Thr Phe Thr Leu Ala  Ile Ser Ala Tyr Ala  Leu Ser Leu 
    1190                 1195                 1200             


Gly Asp  Lys Thr His Pro Gln  Phe Arg Ser Ile Val  Ser Ala Leu 
    1205                 1210                 1215             


Lys Arg  Glu Ala Leu Val Lys  Gly Asn Pro Pro Ile  Tyr Arg Phe 
    1220                 1225                 1230             


Trp Lys  Asp Asn Leu Gln His  Lys Asp Ser Ser Val  Pro Asn Thr 
    1235                 1240                 1245             


Gly Thr  Ala Arg Met Val Glu  Thr Thr Ala Tyr Ala  Leu Leu Thr 
    1250                 1255                 1260             


Ser Leu  Asn Leu Lys Asp Ile  Asn Tyr Val Asn Pro  Val Ile Lys 
    1265                 1270                 1275             


Trp Leu  Ser Glu Glu Gln Arg  Tyr Gly Gly Gly Phe  Tyr Ser Thr 
    1280                 1285                 1290             


Gln Asp  Thr Ile Asn Ala Ile  Glu Gly Leu Thr Glu  Tyr Ser Leu 
    1295                 1300                 1305             


Leu Val  Lys Gln Leu Arg Leu  Ser Met Asp Ile Asp  Val Ser Tyr 
    1310                 1315                 1320             


Lys His  Lys Gly Ala Leu His  Asn Tyr Lys Met Thr  Asp Lys Asn 
    1325                 1330                 1335             


Phe Leu  Gly Arg Pro Val Glu  Val Leu Leu Asn Asp  Asp Leu Ile 
    1340                 1345                 1350             


Val Ser  Thr Gly Phe Gly Ser  Gly Leu Ala Thr Val  His Val Thr 
    1355                 1360                 1365             


Thr Val  Val His Lys Thr Ser  Thr Ser Glu Glu Val  Cys Ser Phe 
    1370                 1375                 1380             


Tyr Leu  Lys Ile Asp Thr Gln  Asp Ile Glu Ala Ser  His Tyr Arg 
    1385                 1390                 1395             


Gly Tyr  Gly Asn Ser Asp Tyr  Lys Arg Ile Val Ala  Cys Ala Ser 
    1400                 1405                 1410             


Tyr Lys  Pro Ser Arg Glu Glu  Ser Ser Ser Gly Ser  Ser His Ala 
    1415                 1420                 1425             


Val Met  Asp Ile Ser Leu Pro  Thr Gly Ile Ser Ala  Asn Glu Glu 
    1430                 1435                 1440             


Asp Leu  Lys Ala Leu Val Glu  Gly Val Asp Gln Leu  Phe Thr Asp 
    1445                 1450                 1455             


Tyr Gln  Ile Lys Asp Gly His  Val Ile Leu Gln Leu  Asn Ser Ile 
    1460                 1465                 1470             


Pro Ser  Ser Asp Phe Leu Cys  Val Arg Phe Arg Ile  Phe Glu Leu 
    1475                 1480                 1485             


Phe Glu  Val Gly Phe Leu Ser  Pro Ala Thr Phe Thr  Val Tyr Glu 
    1490                 1495                 1500             


Tyr His  Arg Pro Asp Lys Gln  Cys Thr Met Phe Tyr  Ser Thr Ser 
    1505                 1510                 1515             


Asn Ile  Lys Ile Gln Lys Val  Cys Glu Gly Ala Ala  Cys Lys Cys 
    1520                 1525                 1530             


Val Glu  Ala Asp Cys Gly Gln  Met Gln Glu Glu Leu  Asp Leu Thr 
    1535                 1540                 1545             


Ile Ser  Ala Glu Thr Arg Lys  Gln Thr Ala Cys Lys  Pro Glu Ile 
    1550                 1555                 1560             


Ala Tyr  Ala Tyr Lys Val Ser  Ile Thr Ser Ile Thr  Val Glu Asn 
    1565                 1570                 1575             


Val Phe  Val Lys Tyr Lys Ala  Thr Leu Leu Asp Ile  Tyr Lys Thr 
    1580                 1585                 1590             


Gly Glu  Ala Val Ala Glu Lys  Asp Ser Glu Ile Thr  Phe Ile Lys 
    1595                 1600                 1605             


Lys Val  Thr Cys Thr Asn Ala  Glu Leu Val Lys Gly  Arg Gln Tyr 
    1610                 1615                 1620             


Leu Ile  Met Gly Lys Glu Ala  Leu Gln Ile Lys Tyr  Asn Phe Ser 
    1625                 1630                 1635             


Phe Arg  Tyr Ile Tyr Pro Leu  Asp Ser Leu Thr Trp  Ile Glu Tyr 
    1640                 1645                 1650             


Trp Pro  Arg Asp Thr Thr Cys  Ser Ser Cys Gln Ala  Phe Leu Ala 
    1655                 1660                 1665             


Asn Leu  Asp Glu Phe Ala Glu  Asp Ile Phe Leu Asn  Gly Cys 
    1670                 1675                 1680         


<210>  316
<211>  902
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C5B, isoform 3 <Accession No.: NP_001304093.1>

<400>  316

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Ser Leu Ala Leu Ser Pro Arg Leu Glu Cys 
    850                 855                 860                 


Asn Gly Lys Ile Ser Gly His Cys Lys Leu Arg Leu Pro Gly Ser Ser 
865                 870                 875                 880 


Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Gly Thr His 
                885                 890                 895     


His His Ala Gln Pro Thr 
            900         


<210>  317
<211>  934
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C6 <Accession No.: NP_001108603.2>

<400>  317

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  318
<211>  843
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C7 <Accession No.: NP_000578.2>

<400>  318

Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 
    50                  55                  60                  


Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 
65                  70                  75                  80  


Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 
                85                  90                  95      


Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 
            100                 105                 110         


Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 
        115                 120                 125             


Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 
    130                 135                 140                 


Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 
145                 150                 155                 160 


Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 
                165                 170                 175     


Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 
            180                 185                 190         


Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 
        195                 200                 205             


Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 
    210                 215                 220                 


Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 
225                 230                 235                 240 


Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 
                245                 250                 255     


Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 
            260                 265                 270         


Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 
        275                 280                 285             


Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 
    290                 295                 300                 


Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 
305                 310                 315                 320 


Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 
                325                 330                 335     


Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 
            340                 345                 350         


Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 
        355                 360                 365             


Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 
    370                 375                 380                 


Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 
385                 390                 395                 400 


Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 
                405                 410                 415     


Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 
            420                 425                 430         


Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 
        435                 440                 445             


Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 
    450                 455                 460                 


Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 
                485                 490                 495     


Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 
            500                 505                 510         


Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 
        515                 520                 525             


Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 
    530                 535                 540                 


Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 
545                 550                 555                 560 


Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 
                565                 570                 575     


Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 
            580                 585                 590         


Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 
        595                 600                 605             


Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 
    610                 615                 620                 


His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 
625                 630                 635                 640 


Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 
                645                 650                 655     


Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 
            660                 665                 670         


Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 
        675                 680                 685             


Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 
    690                 695                 700                 


Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 
705                 710                 715                 720 


Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 
                725                 730                 735     


Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 
            740                 745                 750         


Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 
        755                 760                 765             


Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 
    770                 775                 780                 


Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 
785                 790                 795                 800 


Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 
                805                 810                 815     


Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 
            820                 825                 830         


Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840             


<210>  319
<211>  584
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C8 ALPHA SUBUNIT <Accession No.: NP_000553.1>

<400>  319

Met Phe Ala Val Val Phe Phe Ile Leu Ser Leu Met Thr Cys Gln Pro 
1               5                   10                  15      


Gly Val Thr Ala Gln Glu Lys Val Asn Gln Arg Val Arg Arg Ala Ala 
            20                  25                  30          


Thr Pro Ala Ala Val Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr 
        35                  40                  45              


Asp Cys Phe Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu 
    50                  55                  60                  


Gln Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp 
65                  70                  75                  80  


Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln Cys 
                85                  90                  95      


Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu Lys Arg His 
            100                 105                 110         


Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp Gly Ser Asp Glu Asp 
        115                 120                 125             


Asp Cys Glu Asp Val Arg Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu 
    130                 135                 140                 


Pro Ile Pro Gly Ser Gln Lys Ala Ala Leu Gly Tyr Asn Ile Leu Thr 
145                 150                 155                 160 


Gln Glu Asp Ala Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln 
                165                 170                 175     


Cys Glu Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser 
            180                 185                 190         


Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr Gly 
    210                 215                 220                 


Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu Ser Lys Val 
225                 230                 235                 240 


Lys Lys Asp Lys Ser Asp Ser Phe Gly Val Thr Ile Gly Ile Gly Pro 
                245                 250                 255     


Ala Gly Ser Pro Leu Leu Val Gly Val Gly Val Ser His Ser Gln Asp 
            260                 265                 270         


Thr Ser Phe Leu Asn Glu Leu Asn Lys Tyr Asn Glu Lys Lys Phe Ile 
        275                 280                 285             


Phe Thr Arg Ile Phe Thr Lys Val Gln Thr Ala His Phe Lys Met Arg 
    290                 295                 300                 


Lys Asp Asp Ile Met Leu Asp Glu Gly Met Leu Gln Ser Leu Met Glu 
305                 310                 315                 320 


Leu Pro Asp Gln Tyr Asn Tyr Gly Met Tyr Ala Lys Phe Ile Asn Asp 
                325                 330                 335     


Tyr Gly Thr His Tyr Ile Thr Ser Gly Ser Met Gly Gly Ile Tyr Glu 
            340                 345                 350         


Tyr Ile Leu Val Ile Asp Lys Ala Lys Met Glu Ser Leu Gly Ile Thr 
        355                 360                 365             


Ser Arg Asp Ile Thr Thr Cys Phe Gly Gly Ser Leu Gly Ile Gln Tyr 
    370                 375                 380                 


Glu Asp Lys Ile Asn Val Gly Gly Gly Leu Ser Gly Asp His Cys Lys 
385                 390                 395                 400 


Lys Phe Gly Gly Gly Lys Thr Glu Arg Ala Arg Lys Ala Met Ala Val 
                405                 410                 415     


Glu Asp Ile Ile Ser Arg Val Arg Gly Gly Ser Ser Gly Trp Ser Gly 
            420                 425                 430         


Gly Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr Arg Ser Trp Gly Arg 
        435                 440                 445             


Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe Glu Met Gln Pro Ile 
    450                 455                 460                 


His Glu Val Leu Arg His Thr Ser Leu Gly Pro Leu Glu Ala Lys Arg 
465                 470                 475                 480 


Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu Met Glu Phe Asn Ala 
                485                 490                 495     


Cys Arg Cys Gly Pro Cys Phe Asn Asn Gly Val Pro Ile Leu Glu Gly 
            500                 505                 510         


Thr Ser Cys Arg Cys Gln Cys Arg Leu Gly Ser Leu Gly Ala Ala Cys 
        515                 520                 525             


Glu Gln Thr Gln Thr Glu Gly Ala Lys Ala Asp Gly Ser Trp Ser Cys 
    530                 535                 540                 


Trp Ser Ser Trp Ser Val Cys Arg Ala Gly Ile Gln Glu Arg Arg Arg 
545                 550                 555                 560 


Glu Cys Asp Asn Pro Ala Pro Gln Asn Gly Gly Ala Ser Cys Pro Gly 
                565                 570                 575     


Arg Lys Val Gln Thr Gln Ala Cys 
            580                 


<210>  320
<211>  591
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C8 BETA SUBUNIT <Accession No.: AAA51862.1>

<400>  320

Met Lys Asn Ser Arg Thr Trp Ala Trp Arg Ala Pro Val Glu Leu Phe 
1               5                   10                  15      


Leu Leu Cys Ala Ala Leu Gly Cys Leu Ser Leu Pro Gly Ser Arg Gly 
            20                  25                  30          


Glu Arg Pro His Ser Phe Gly Ser Asn Ala Val Asn Lys Ser Phe Ala 
        35                  40                  45              


Lys Ser Arg Gln Met Arg Ser Val Asp Val Thr Leu Met Pro Ile Asp 
    50                  55                  60                  


Cys Glu Leu Ser Ser Trp Ser Ser Trp Thr Thr Cys Asp Pro Cys Gln 
65                  70                  75                  80  


Lys Lys Arg Tyr Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln Phe His 
                85                  90                  95      


Gly Glu Pro Cys Asn Phe Ser Asp Lys Glu Val Glu Asp Cys Val Thr 
            100                 105                 110         


Asn Arg Pro Cys Gly Ser Gln Val Arg Cys Glu Gly Phe Val Cys Ala 
        115                 120                 125             


Gln Thr Gly Arg Cys Val Asn Arg Arg Leu Leu Cys Asn Gly Asp Asn 
    130                 135                 140                 


Asp Cys Gly Asp Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile Tyr Lys 
145                 150                 155                 160 


Lys Cys Gln His Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser Leu Ala 
                165                 170                 175     


Ser Gly Ile Asn Leu Phe Thr Asn Ser Phe Glu Gly Pro Val Leu Asp 
            180                 185                 190         


His Arg Tyr Tyr Ala Gly Gly Cys Ser Pro His Tyr Ile Leu Asn Thr 
        195                 200                 205             


Arg Phe Arg Lys Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln Thr Gln 
    210                 215                 220                 


Gly Lys Tyr Glu Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser Asp Phe 
225                 230                 235                 240 


Glu Arg Asn Val Thr Glu Lys Met Ala Ser Lys Ser Gly Phe Ser Phe 
                245                 250                 255     


Gly Phe Lys Ile Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser Gln Ser 
            260                 265                 270         


Asp Arg Gly Lys His Tyr Ile Arg Arg Thr Lys Arg Phe Ser His Thr 
        275                 280                 285             


Lys Ser Val Phe Leu His Ala Arg Ser Asp Leu Glu Val Ala His Tyr 
    290                 295                 300                 


Lys Leu Lys Pro Arg Ser Leu Met Leu His Tyr Glu Phe Leu Gln Arg 
305                 310                 315                 320 


Val Lys Arg Leu Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg Asp Leu 
                325                 330                 335     


Phe Arg Asp Phe Gly Thr His Tyr Ile Thr Glu Ala Val Leu Gly Gly 
            340                 345                 350         


Ile Tyr Glu Tyr Thr Leu Val Met Asn Lys Glu Ala Met Glu Arg Gly 
        355                 360                 365             


Asp Tyr Thr Leu Asn Asn Val His Ala Cys Ala Lys Asn Asp Phe Lys 
    370                 375                 380                 


Ile Gly Gly Ala Ile Glu Glu Val Tyr Val Ser Leu Gly Val Ser Val 
385                 390                 395                 400 


Gly Lys Cys Arg Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn Lys Arg 
                405                 410                 415     


Asp Thr Met Val Glu Asp Leu Val Val Leu Val Arg Gly Gly Ala Ser 
            420                 425                 430         


Glu His Ile Thr Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala Asp Leu 
        435                 440                 445             


Met Gln Glu Trp Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile Ile Lys 
    450                 455                 460                 


Val Lys Val Glu Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp Phe Ala 
465                 470                 475                 480 


Tyr Ser Ser Thr Val Arg Gln Asn Met Lys Gln Ala Leu Glu Glu Phe 
                485                 490                 495     


Gln Lys Glu Val Ser Ser Cys His Cys Ala Pro Cys Gln Gly Asn Gly 
            500                 505                 510         


Val Pro Val Leu Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro Val Gly 
        515                 520                 525             


Ser Gln Gly Leu Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr Pro Ile 
    530                 535                 540                 


Asp Gly Lys Trp Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser Gly Arg 
545                 550                 555                 560 


Arg Lys Thr Arg Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln Asn Gly 
                565                 570                 575     


Gly Ser Pro Cys Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys Ser 
            580                 585                 590     


<210>  321
<211>  202
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C8 GAMMA SUBUNIT <Accession No.: AAA51888.1>

<400>  321

Met Leu Pro Pro Gly Thr Ala Thr Leu Leu Thr Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Leu Gly Gln Lys Pro Gln Arg Pro Arg Arg Pro Ala Ser Pro 
            20                  25                  30          


Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala Gln Gln Phe Ala 
        35                  40                  45              


Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Cys Arg Phe Leu Gln 
    50                  55                  60                  


Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His Val Ala Pro Gln 
65                  70                  75                  80  


Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu Asp Gly Ile Cys 
                85                  90                  95      


Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val Leu Gly Arg Phe 
            100                 105                 110         


Leu Leu Gln Ala Arg Gly Ala Arg Gly Ala Val His Val Val Val Ala 
        115                 120                 125             


Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu Glu Arg Ala Gly 
    130                 135                 140                 


Gln Leu Ser Val Lys Leu Tyr Ala Arg Ser Leu Pro Val Ser Asp Ser 
145                 150                 155                 160 


Val Leu Ser Gly Phe Glu Gln Arg Val Gln Glu Ala His Leu Thr Glu 
                165                 170                 175     


Asp Gln Ile Phe Tyr Phe Pro Lys Tyr Gly Phe Cys Glu Ala Ala Asp 
            180                 185                 190         


Gln Phe His Val Leu Asp Glu Val Arg Arg 
        195                 200         


