                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Yeh, Jen Jen
       Miffitt, Richard
       Rashid, Naim Ur
 
<120>  PURITY INDEPENDENT SUBTYPING OF TUMORS (PURIST), A PLATFORM AND 
       SAMPLE TYPE INDEPENDENT SINGLE SAMPLE CLASSIFIER FOR TREATMENT 
       DECISION MAKING IN PANCREATIC CANCER

<130>  421/454 PCT

<150>  US 62/827,473
<151>  2019-04-01

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  1441
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (165)..(1139)

<400>  1
atccagattt gcttttacat tttcttgcct gagtctgagg tgaacagtga acatatttac       60

atttgattta acagtgaacc ttaattcttt ctggcttcac agtgaaacaa gtttatgcaa      120

tcgatcaaat attttcatcc ctgaggttaa caattaccat caaa atg ttt tgt gga       176
                                                 Met Phe Cys Gly          
                                                 1                        

gac tat gtg caa gga acc atc ttc cca gct ccc aat ttc aat ccc ata        224
Asp Tyr Val Gln Gly Thr Ile Phe Pro Ala Pro Asn Phe Asn Pro Ile           
5                   10                  15                  20            

atg gat gcc caa atg cta gga gga gca ctc caa gga ttt gac tgt gac        272
Met Asp Ala Gln Met Leu Gly Gly Ala Leu Gln Gly Phe Asp Cys Asp           
                25                  30                  35                

aaa gac atg ctg atc aac att ctg act cag cgc tgc aat gca caa agg        320
Lys Asp Met Leu Ile Asn Ile Leu Thr Gln Arg Cys Asn Ala Gln Arg           
            40                  45                  50                    

atg atg att gca gag gca tac cag agc atg tat ggc cgg gac ctg att        368
Met Met Ile Ala Glu Ala Tyr Gln Ser Met Tyr Gly Arg Asp Leu Ile           
        55                  60                  65                        

ggg gat atg agg gag cag ctt tcg gat cac ttc aaa gat gtg atg gct        416
Gly Asp Met Arg Glu Gln Leu Ser Asp His Phe Lys Asp Val Met Ala           
    70                  75                  80                            

ggc ctc atg tac cca cca cca ctg tat gat gct cat gag ctc tgg cat        464
Gly Leu Met Tyr Pro Pro Pro Leu Tyr Asp Ala His Glu Leu Trp His           
85                  90                  95                  100           

gcc atg aag gga gta ggc act gat gag aat tgc ctc att gaa ata cta        512
Ala Met Lys Gly Val Gly Thr Asp Glu Asn Cys Leu Ile Glu Ile Leu           
                105                 110                 115               

gct tca aga aca aat gga gaa att ttc cag atg cga gaa gcc tac tgc        560
Ala Ser Arg Thr Asn Gly Glu Ile Phe Gln Met Arg Glu Ala Tyr Cys           
            120                 125                 130                   

ttg caa tac agc aat aac ctc caa gag gac att tat tca gag acc tca        608
Leu Gln Tyr Ser Asn Asn Leu Gln Glu Asp Ile Tyr Ser Glu Thr Ser           
        135                 140                 145                       

gga cac ttc aga gat act ctc atg aac ttg gtc cag ggg acc aga gag        656
Gly His Phe Arg Asp Thr Leu Met Asn Leu Val Gln Gly Thr Arg Glu           
    150                 155                 160                           

gaa gga tat aca gac cct gcg atg gct gct cag gat gca atg gtc cta        704
Glu Gly Tyr Thr Asp Pro Ala Met Ala Ala Gln Asp Ala Met Val Leu           
165                 170                 175                 180           

tgg gaa gcc tgt cag cag aag acg ggg gag cac aaa acc atg ctg caa        752
Trp Glu Ala Cys Gln Gln Lys Thr Gly Glu His Lys Thr Met Leu Gln           
                185                 190                 195               

atg atc ctg tgc aac aag agc tac cag cag ctg cgg ctg gtt ttc cag        800
Met Ile Leu Cys Asn Lys Ser Tyr Gln Gln Leu Arg Leu Val Phe Gln           
            200                 205                 210                   

gaa ttt caa aat att tct ggg caa gat atg gta gat gcc att aat gaa        848
Glu Phe Gln Asn Ile Ser Gly Gln Asp Met Val Asp Ala Ile Asn Glu           
        215                 220                 225                       

tgt tat gat gga tac ttt cag gag ctg ctg gtt gca att gtt ctc tgt        896
Cys Tyr Asp Gly Tyr Phe Gln Glu Leu Leu Val Ala Ile Val Leu Cys           
    230                 235                 240                           

gtt cga gac aaa cca gcc tat ttt gct tat aga tta tat agt gca att        944
Val Arg Asp Lys Pro Ala Tyr Phe Ala Tyr Arg Leu Tyr Ser Ala Ile           
245                 250                 255                 260           

cat gac ttt ggt ttc cat aat aaa act gta atc agg att ctc att gcc        992
His Asp Phe Gly Phe His Asn Lys Thr Val Ile Arg Ile Leu Ile Ala           
                265                 270                 275               

aga agt gaa ata gac ctg ctg acc ata agg aaa cga tac aaa gag cga       1040
Arg Ser Glu Ile Asp Leu Leu Thr Ile Arg Lys Arg Tyr Lys Glu Arg           
            280                 285                 290                   

tat gga aaa tcc cta ttt cat gat atc aga aat ttt gct tca ggg cat       1088
Tyr Gly Lys Ser Leu Phe His Asp Ile Arg Asn Phe Ala Ser Gly His           
        295                 300                 305                       

tat aag aaa gca ctg ctt gcc atc tgt gct ggt gat gct gag gac tac       1136
Tyr Lys Lys Ala Leu Leu Ala Ile Cys Ala Gly Asp Ala Glu Asp Tyr           
    310                 315                 320                           

taa aatgaagagg acttggagta ctgtgcactc ctctttctag acacttccaa            1189

atagagattt tctcacaaat ttgtactgtt catggcacta ttaacaaaac tatacaatca     1249

tattttctct tctatctttg aaattattct aagccaaaga aaactatgaa tgaaagtata     1309

tgatactgaa tttgcctact atcctgaatt tgcctactat ctaatcagca attaaataaa     1369

ttgtgcatga tggaataata gaaaaattgc attggaatag attttattta aatgtgaacc     1429

atcaacaacc ta                                                         1441


<210>  2
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Cys Gly Asp Tyr Val Gln Gly Thr Ile Phe Pro Ala Pro Asn 
1               5                   10                  15      


Phe Asn Pro Ile Met Asp Ala Gln Met Leu Gly Gly Ala Leu Gln Gly 
            20                  25                  30          


Phe Asp Cys Asp Lys Asp Met Leu Ile Asn Ile Leu Thr Gln Arg Cys 
        35                  40                  45              


Asn Ala Gln Arg Met Met Ile Ala Glu Ala Tyr Gln Ser Met Tyr Gly 
    50                  55                  60                  


Arg Asp Leu Ile Gly Asp Met Arg Glu Gln Leu Ser Asp His Phe Lys 
65                  70                  75                  80  


Asp Val Met Ala Gly Leu Met Tyr Pro Pro Pro Leu Tyr Asp Ala His 
                85                  90                  95      


Glu Leu Trp His Ala Met Lys Gly Val Gly Thr Asp Glu Asn Cys Leu 
            100                 105                 110         


Ile Glu Ile Leu Ala Ser Arg Thr Asn Gly Glu Ile Phe Gln Met Arg 
        115                 120                 125             


Glu Ala Tyr Cys Leu Gln Tyr Ser Asn Asn Leu Gln Glu Asp Ile Tyr 
    130                 135                 140                 


Ser Glu Thr Ser Gly His Phe Arg Asp Thr Leu Met Asn Leu Val Gln 
145                 150                 155                 160 


Gly Thr Arg Glu Glu Gly Tyr Thr Asp Pro Ala Met Ala Ala Gln Asp 
                165                 170                 175     


Ala Met Val Leu Trp Glu Ala Cys Gln Gln Lys Thr Gly Glu His Lys 
            180                 185                 190         


Thr Met Leu Gln Met Ile Leu Cys Asn Lys Ser Tyr Gln Gln Leu Arg 
        195                 200                 205             


Leu Val Phe Gln Glu Phe Gln Asn Ile Ser Gly Gln Asp Met Val Asp 
    210                 215                 220                 


Ala Ile Asn Glu Cys Tyr Asp Gly Tyr Phe Gln Glu Leu Leu Val Ala 
225                 230                 235                 240 


Ile Val Leu Cys Val Arg Asp Lys Pro Ala Tyr Phe Ala Tyr Arg Leu 
                245                 250                 255     


Tyr Ser Ala Ile His Asp Phe Gly Phe His Asn Lys Thr Val Ile Arg 
            260                 265                 270         


Ile Leu Ile Ala Arg Ser Glu Ile Asp Leu Leu Thr Ile Arg Lys Arg 
        275                 280                 285             


Tyr Lys Glu Arg Tyr Gly Lys Ser Leu Phe His Asp Ile Arg Asn Phe 
    290                 295                 300                 


Ala Ser Gly His Tyr Lys Lys Ala Leu Leu Ala Ile Cys Ala Gly Asp 
305                 310                 315                 320 


Ala Glu Asp Tyr 
                


<210>  3
<211>  3336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (359)..(2836)

<400>  3
ctctccggcg gccgctccag cccggccggg accccagagt tgcaggccca ggccagccgt       60

tgcaccgtta agccgggccg gtgacgccgg gcctttacgt cgcgcctgtg agcggccgag      120

gccgagcggc ctcccctcgg gctgcgagac ggagacatta cctcatccct caagattgct      180

cgctgcaaac acaacgctga gaaatggccc aagtaaagcg tgatcagggt cttgcattct      240

tggcacatct aggaagaacg tgcaaggatg cgaattgtga atcgcttctc caaacagagc      300

tgcttcatct gacccaagct ggcctggaga aaggaggaag aggcaagagt tgagaatt        358

atg gct gca gga aaa ttt gca agc ctt ccc aga aac atg ccg gtg aat        406
Met Ala Ala Gly Lys Phe Ala Ser Leu Pro Arg Asn Met Pro Val Asn           
1               5                   10                  15                

cac cag ttc ccc ctg gcc tca tcc atg gac ctt ctg agc agc agg tcc        454
His Gln Phe Pro Leu Ala Ser Ser Met Asp Leu Leu Ser Ser Arg Ser           
            20                  25                  30                    

cct ctc gct gag cat cgc cca gat gcc tat caa gat gtg tct ata cat        502
Pro Leu Ala Glu His Arg Pro Asp Ala Tyr Gln Asp Val Ser Ile His           
        35                  40                  45                        

ggc acc ctt cca cgg aag aaa aaa ggt cct cct ccc ata agg tcc tgt        550
Gly Thr Leu Pro Arg Lys Lys Lys Gly Pro Pro Pro Ile Arg Ser Cys           
    50                  55                  60                            

gat gac ttc agt cac atg ggc acc ctc ccc cac tcc aaa tcc cca cgg        598
Asp Asp Phe Ser His Met Gly Thr Leu Pro His Ser Lys Ser Pro Arg           
65                  70                  75                  80            

cag aac tcg cct gtg acc cag gat ggc atc cag gag agc cca tgg cag        646
Gln Asn Ser Pro Val Thr Gln Asp Gly Ile Gln Glu Ser Pro Trp Gln           
                85                  90                  95                

gac cgg cac ggc gaa acc ttc acc ttc agg gat cca cat ctt ctg gac        694
Asp Arg His Gly Glu Thr Phe Thr Phe Arg Asp Pro His Leu Leu Asp           
            100                 105                 110                   

cca act gtg gaa tat gtg aag ttc tcc aag gag agg cac atc atg gac        742
Pro Thr Val Glu Tyr Val Lys Phe Ser Lys Glu Arg His Ile Met Asp           
        115                 120                 125                       

agg acc ccc gag aaa ctg aag aag gag ctg gag gag gag ctg ctc ctg        790
Arg Thr Pro Glu Lys Leu Lys Lys Glu Leu Glu Glu Glu Leu Leu Leu           
    130                 135                 140                           

agc agc gag gac ctg cgc agc cat gcc tgg tac cac ggc cgc atc ccc        838
Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro           
145                 150                 155                 160           

cga cag gtg tct gaa aac ctt gtg cag cga gat ggt gac ttc cta gtt        886
Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp Gly Asp Phe Leu Val           
                165                 170                 175               

cgt gac tct ctg tcc agc cct ggg aac ttt gtc ctg acc tgt cag tgg        934
Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val Leu Thr Cys Gln Trp           
            180                 185                 190                   

aag aac ctc gct cag cac ttc aaa atc aac cgg aca gtt ctg cga ctc        982
Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg Thr Val Leu Arg Leu           
        195                 200                 205                       

agc gag gcc tac agc cgc gtg cag tac cag ttc gag atg gag agc ttc       1030
Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe Glu Met Glu Ser Phe           
    210                 215                 220                           

gac tcc atc ccc ggc ctg gtg cgc tgc tac gtg ggc aac cgc cgg ccc       1078
Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val Gly Asn Arg Arg Pro           
225                 230                 235                 240           

atc tcc cag cag agt ggc gcc atc atc ttc cag ccc atc aac agg acg       1126
Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln Pro Ile Asn Arg Thr           
                245                 250                 255               

gtg cct ctg cgg tgc ctg gag gag cat tat ggc acc tcc cca ggc cag       1174
Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly Thr Ser Pro Gly Gln           
            260                 265                 270                   

gcc cgg gag ggc agc ctc acc aag gga agg ccg gat gtg gcc aag agg       1222
Ala Arg Glu Gly Ser Leu Thr Lys Gly Arg Pro Asp Val Ala Lys Arg           
        275                 280                 285                       

ctg agc ctc acc atg ggt ggc gtc cag gcc cga gag cag aat ttg ccc       1270
Leu Ser Leu Thr Met Gly Gly Val Gln Ala Arg Glu Gln Asn Leu Pro           
    290                 295                 300                           

agg gga aac ctc ctc aga aac aaa gaa aag agt ggt agc cag ccc gcc       1318
Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser Gly Ser Gln Pro Ala           
305                 310                 315                 320           

tgc ctg gat cac atg cag gac aga aga gcc ttg tcc ctc aaa gcc cac       1366
Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala His           
                325                 330                 335               

cag tca gag agc tac ctg ccg att ggc tgc aag ctg cca cct cag tcc       1414
Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln Ser           
            340                 345                 350                   

tcg ggt gtg gac aca agc ccc tgc cca aac tca cct gtg ttc agg acg       1462
Ser Gly Val Asp Thr Ser Pro Cys Pro Asn Ser Pro Val Phe Arg Thr           
        355                 360                 365                       

gga agc gag cct gcc ctg agc cca gca gtg gtt cgg agg gtc tcc tca       1510
Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser Ser           
    370                 375                 380                           

gac gcc agg gct ggg gag gcg ctg agg gga tca gac agt caa ctg tgc       1558
Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu Cys           
385                 390                 395                 400           

cct aag ccc ccg cct aag ccc tgc aag gtg ccg ttc ctc aag gtt ccc       1606
Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val Pro           
                405                 410                 415               

tcg tct ccc tct gcc tgg ctc aac tca gag gcc aac tac tgt gaa ctg       1654
Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu Leu           
            420                 425                 430                   

aac cca gcg ttt gcc aca ggc tgc ggc agg gga gca aag cta ccc tca       1702
Asn Pro Ala Phe Ala Thr Gly Cys Gly Arg Gly Ala Lys Leu Pro Ser           
        435                 440                 445                       

tgt gcc cag gga agc cac aca gaa ctg ctc aca gcc aag cag aat gag       1750
Cys Ala Gln Gly Ser His Thr Glu Leu Leu Thr Ala Lys Gln Asn Glu           
    450                 455                 460                           

gcg cca ggt ccc cgg aac tct ggc gtc aac tac ttg atc ctt gat gat       1798
Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp Asp           
465                 470                 475                 480           

gat gac agg gaa aga cct tgg gaa cct gcg gca gct cag atg gag aag       1846
Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu Lys           
                485                 490                 495               

ggg cag tgg gac aag ggc gag ttt gtg acg ccc ctc ctg gag act gtc       1894
Gly Gln Trp Asp Lys Gly Glu Phe Val Thr Pro Leu Leu Glu Thr Val           
            500                 505                 510                   

tcc tcc ttc agg ccc aac gag ttt gag tca aag ttc ctt ccc cct gag       1942
Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro Glu           
        515                 520                 525                       

aat aag ccc ctg gaa aca gca atg ttg aaa cgt gca aaa gaa ctg ttc       1990
Asn Lys Pro Leu Glu Thr Ala Met Leu Lys Arg Ala Lys Glu Leu Phe           
    530                 535                 540                           

acc aac aac gac ccc aag gtc atc gcc cag cac gta ctg agc atg gac       2038
Thr Asn Asn Asp Pro Lys Val Ile Ala Gln His Val Leu Ser Met Asp           
545                 550                 555                 560           

tgc agg gtt gct agg ata ctt gga gtc tct gaa gag atg agg agg aac       2086
Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg Asn           
                565                 570                 575               

atg ggg gtg agc tca ggc ctg gaa ctc att acc ttg cct cac gga cac       2134
Met Gly Val Ser Ser Gly Leu Glu Leu Ile Thr Leu Pro His Gly His           
            580                 585                 590                   

cag ctg cgc ctg gac ata att gaa aga cac aac aca atg gcc atc ggc       2182
Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn Thr Met Ala Ile Gly           
        595                 600                 605                       

att gca gtg gac att ctg gga tgc acg ggc act ttg gag gac cga gcg       2230
Ile Ala Val Asp Ile Leu Gly Cys Thr Gly Thr Leu Glu Asp Arg Ala           
    610                 615                 620                           

gcc act ctg agt aag atc atc cag gtg gcg gtg gaa ctg aag gat tcc       2278
Ala Thr Leu Ser Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp Ser           
625                 630                 635                 640           

atg ggg gac ctc tat tcc ttc tca gct ctc atg aaa gcc ctg gaa atg       2326
Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu Met           
                645                 650                 655               

cca cag atc aca agg tta gaa aag acg tgg act gct ctg cgg cac cag       2374
Pro Gln Ile Thr Arg Leu Glu Lys Thr Trp Thr Ala Leu Arg His Gln           
            660                 665                 670                   

tac acc caa act gcc att ctc tat gag aaa cag ctg aag ccc ttc agc       2422
Tyr Thr Gln Thr Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe Ser           
        675                 680                 685                       

aaa ctc ctg cat gaa ggc aga gag tcc aca tgt gtt ccc cca aac aat       2470
Lys Leu Leu His Glu Gly Arg Glu Ser Thr Cys Val Pro Pro Asn Asn           
    690                 695                 700                           

gta tca gtc cca ctg ctg atg ccg ctt gtg acg tta atg gag cgc cag       2518
Val Ser Val Pro Leu Leu Met Pro Leu Val Thr Leu Met Glu Arg Gln           
705                 710                 715                 720           

gct gtg act ttt gaa gga acc gac atg tgg gaa aaa aac gac cag agc       2566
Ala Val Thr Phe Glu Gly Thr Asp Met Trp Glu Lys Asn Asp Gln Ser           
                725                 730                 735               

tgt gaa atc atg ctg aac cat ttg gca aca gcg cga ttc atg gcc gag       2614
Cys Glu Ile Met Leu Asn His Leu Ala Thr Ala Arg Phe Met Ala Glu           
            740                 745                 750                   

gct gca gac agc tac cgg atg aat gct gag agg atc ctg gca ggt ttt       2662
Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly Phe           
        755                 760                 765                       

caa cca gat gaa gaa atg aat gaa atc tgc aag act gaa ttt caa atg       2710
Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys Thr Glu Phe Gln Met           
    770                 775                 780                           

cga ttg cta tgg ggc agc aaa ggt gca caa gtc aat cag aca gag aga       2758
Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val Asn Gln Thr Glu Arg           
785                 790                 795                 800           

tat gag aaa ttc aac cag att tta act gcc ctc tcg cgt aaa ttg gaa       2806
Tyr Glu Lys Phe Asn Gln Ile Leu Thr Ala Leu Ser Arg Lys Leu Glu           
                805                 810                 815               

cct cct cct gta aag cag gca gag ctt tga taactctcca gagaaccttt         2856
Pro Pro Pro Val Lys Gln Ala Glu Leu                                       
            820                 825                                       

agaatatctt ttcaagtttc cccagcttca tctttgggaa agcttactgt ttttgataaa     2916

gtaataatgt gcaaatctga caatatacaa gcttttagta tccacaggat attaaacgtg     2976

taaattgcac agagcacact tatttatgaa ttgtctaaag ttactactga ttttaaaatg     3036

aataatttat tattaaggta actactgcta atgttgatca gcaaatttaa gagaagacct     3096

agctatgttg gctggttgct ttctattatc atggtatttg accattttag ttttaattcc     3156

atgtcagata agtgtaaata gaagagttta aaagcatgaa acatttcaga aggtatcagt     3216

tatatgatat tctttaaaca aatatgaaaa atgtaaatac tcatgaatga aaatacatct     3276

ttttgtgaaa cagttgtatc cagtctcttt catattaaac aactcatctt ggtacaataa     3336


<210>  4
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Gly Lys Phe Ala Ser Leu Pro Arg Asn Met Pro Val Asn 
1               5                   10                  15      


His Gln Phe Pro Leu Ala Ser Ser Met Asp Leu Leu Ser Ser Arg Ser 
            20                  25                  30          


Pro Leu Ala Glu His Arg Pro Asp Ala Tyr Gln Asp Val Ser Ile His 
        35                  40                  45              


Gly Thr Leu Pro Arg Lys Lys Lys Gly Pro Pro Pro Ile Arg Ser Cys 
    50                  55                  60                  


Asp Asp Phe Ser His Met Gly Thr Leu Pro His Ser Lys Ser Pro Arg 
65                  70                  75                  80  


Gln Asn Ser Pro Val Thr Gln Asp Gly Ile Gln Glu Ser Pro Trp Gln 
                85                  90                  95      


Asp Arg His Gly Glu Thr Phe Thr Phe Arg Asp Pro His Leu Leu Asp 
            100                 105                 110         


Pro Thr Val Glu Tyr Val Lys Phe Ser Lys Glu Arg His Ile Met Asp 
        115                 120                 125             


Arg Thr Pro Glu Lys Leu Lys Lys Glu Leu Glu Glu Glu Leu Leu Leu 
    130                 135                 140                 


Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro 
145                 150                 155                 160 


Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp Gly Asp Phe Leu Val 
                165                 170                 175     


Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val Leu Thr Cys Gln Trp 
            180                 185                 190         


Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg Thr Val Leu Arg Leu 
        195                 200                 205             


Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe Glu Met Glu Ser Phe 
    210                 215                 220                 


Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val Gly Asn Arg Arg Pro 
225                 230                 235                 240 


Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln Pro Ile Asn Arg Thr 
                245                 250                 255     


Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly Thr Ser Pro Gly Gln 
            260                 265                 270         


Ala Arg Glu Gly Ser Leu Thr Lys Gly Arg Pro Asp Val Ala Lys Arg 
        275                 280                 285             


Leu Ser Leu Thr Met Gly Gly Val Gln Ala Arg Glu Gln Asn Leu Pro 
    290                 295                 300                 


Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser Gly Ser Gln Pro Ala 
305                 310                 315                 320 


Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala His 
                325                 330                 335     


Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln Ser 
            340                 345                 350         


Ser Gly Val Asp Thr Ser Pro Cys Pro Asn Ser Pro Val Phe Arg Thr 
        355                 360                 365             


Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser Ser 
    370                 375                 380                 


Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu Cys 
385                 390                 395                 400 


Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val Pro 
                405                 410                 415     


Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu Leu 
            420                 425                 430         


Asn Pro Ala Phe Ala Thr Gly Cys Gly Arg Gly Ala Lys Leu Pro Ser 
        435                 440                 445             


Cys Ala Gln Gly Ser His Thr Glu Leu Leu Thr Ala Lys Gln Asn Glu 
    450                 455                 460                 


Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp Asp 
465                 470                 475                 480 


Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu Lys 
                485                 490                 495     


Gly Gln Trp Asp Lys Gly Glu Phe Val Thr Pro Leu Leu Glu Thr Val 
            500                 505                 510         


Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro Glu 
        515                 520                 525             


Asn Lys Pro Leu Glu Thr Ala Met Leu Lys Arg Ala Lys Glu Leu Phe 
    530                 535                 540                 


Thr Asn Asn Asp Pro Lys Val Ile Ala Gln His Val Leu Ser Met Asp 
545                 550                 555                 560 


Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg Asn 
                565                 570                 575     


Met Gly Val Ser Ser Gly Leu Glu Leu Ile Thr Leu Pro His Gly His 
            580                 585                 590         


Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn Thr Met Ala Ile Gly 
        595                 600                 605             


Ile Ala Val Asp Ile Leu Gly Cys Thr Gly Thr Leu Glu Asp Arg Ala 
    610                 615                 620                 


Ala Thr Leu Ser Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp Ser 
625                 630                 635                 640 


Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu Met 
                645                 650                 655     


Pro Gln Ile Thr Arg Leu Glu Lys Thr Trp Thr Ala Leu Arg His Gln 
            660                 665                 670         


Tyr Thr Gln Thr Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe Ser 
        675                 680                 685             


Lys Leu Leu His Glu Gly Arg Glu Ser Thr Cys Val Pro Pro Asn Asn 
    690                 695                 700                 


Val Ser Val Pro Leu Leu Met Pro Leu Val Thr Leu Met Glu Arg Gln 
705                 710                 715                 720 


Ala Val Thr Phe Glu Gly Thr Asp Met Trp Glu Lys Asn Asp Gln Ser 
                725                 730                 735     


Cys Glu Ile Met Leu Asn His Leu Ala Thr Ala Arg Phe Met Ala Glu 
            740                 745                 750         


Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly Phe 
        755                 760                 765             


Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys Thr Glu Phe Gln Met 
    770                 775                 780                 


Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val Asn Gln Thr Glu Arg 
785                 790                 795                 800 


Tyr Glu Lys Phe Asn Gln Ile Leu Thr Ala Leu Ser Arg Lys Leu Glu 
                805                 810                 815     


Pro Pro Pro Val Lys Gln Ala Glu Leu 
            820                 825 


<210>  5
<211>  911
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (190)..(420)

<400>  5
aggcgcgcgg ctgcccgagc gccggccggg ccatgacccc cgctgctctg tcttgcaggc       60

tcgtcgccgc ggccccccga gcccgaccgc cgccgccacc accaccagcg cccgggcggg      120

cctcgcgcgc ctcgggcgcg gctccgcagt gagcccacca agaaggaagc ggcctgcaga      180

ggtgccgac atg ggg ctt aag atg tcc tgc ctg aaa ggc ttt caa atg tgt      231
          Met Gly Leu Lys Met Ser Cys Leu Lys Gly Phe Gln Met Cys         
          1               5                   10                          

gtc agc agc agc agc agc agc cac gac gag gcc ccc gtc ctg aac gac        279
Val Ser Ser Ser Ser Ser Ser His Asp Glu Ala Pro Val Leu Asn Asp           
15                  20                  25                  30            

aag cac ctg gac gtg ccc gac atc atc atc acg ccc ccc acc ccc acg        327
Lys His Leu Asp Val Pro Asp Ile Ile Ile Thr Pro Pro Thr Pro Thr           
                35                  40                  45                

ggc atg atg ctg ccg agg gac ttg ggg agc aca gtc tgg ctg gat gag        375
Gly Met Met Leu Pro Arg Asp Leu Gly Ser Thr Val Trp Leu Asp Glu           
            50                  55                  60                    

aca ggg tcg tgc cca gat gat gga gaa atc gac cca gaa gcc tga            420
Thr Gly Ser Cys Pro Asp Asp Gly Glu Ile Asp Pro Glu Ala                   
        65                  70                  75                        

ggaggtgtcc tgggtttggc tggctggctc ctgctccagc ggcccggctt caggtgtccg      480

ggggcgtggc tgcctggagc aggtgtgctg aataccctgg atgggaactg agcgaacccg      540

ggcctccgct cagagagacg tggcaggacc agcgaggaat ccagcctgtc cacttccaga      600

acagtgtttc ccaggccccg ctgagtggac cggacctctg acacctccag gttcttgctg      660

actccggcct ggtgaaaggg agcgccatgg tcctggctgt tggggtccca gggagaggct      720

ctcttctgga caaacacacc ctcccagccc ccagggctgt gcaaacacat gcccctgcca      780

taagcaccaa caagaacttc ttgcaggtgg agtggctgtt ttttataagt tgttttacag      840

atacggaaac agtccaaaat gggatttata atttcttttt tgcattataa ataaagatcc      900

tctgtaacaa a                                                           911


<210>  6
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Leu Lys Met Ser Cys Leu Lys Gly Phe Gln Met Cys Val Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser His Asp Glu Ala Pro Val Leu Asn Asp Lys His 
            20                  25                  30          


Leu Asp Val Pro Asp Ile Ile Ile Thr Pro Pro Thr Pro Thr Gly Met 
        35                  40                  45              


Met Leu Pro Arg Asp Leu Gly Ser Thr Val Trp Leu Asp Glu Thr Gly 
    50                  55                  60                  


Ser Cys Pro Asp Asp Gly Glu Ile Asp Pro Glu Ala 
65                  70                  75      


<210>  7
<211>  3670
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (94)..(2592)

<400>  7
agtcgtagca agagtctcga ccactgaatg gaagaaaagg acttttaacc accattttgt       60

gacttacaga aaggaatttg aataaagaaa act atg ata ctt cag gcc cat ctt       114
                                     Met Ile Leu Gln Ala His Leu          
                                     1               5                    

cac tcc ctg tgt ctt ctt atg ctt tat ttg gca act gga tat ggc caa        162
His Ser Leu Cys Leu Leu Met Leu Tyr Leu Ala Thr Gly Tyr Gly Gln           
        10                  15                  20                        

gag ggg aag ttt agt gga ccc ctg aaa ccc atg aca ttt tct att tat        210
Glu Gly Lys Phe Ser Gly Pro Leu Lys Pro Met Thr Phe Ser Ile Tyr           
    25                  30                  35                            

gaa ggc caa gaa ccg agt caa att ata ttc cag ttt aag gcc aat cct        258
Glu Gly Gln Glu Pro Ser Gln Ile Ile Phe Gln Phe Lys Ala Asn Pro           
40                  45                  50                  55            

cct gct gtg act ttt gaa cta act ggg gag aca gac aac ata ttt gtg        306
Pro Ala Val Thr Phe Glu Leu Thr Gly Glu Thr Asp Asn Ile Phe Val           
                60                  65                  70                

ata gaa cgg gag gga ctt ctg tat tac aac aga gcc ttg gac agg gaa        354
Ile Glu Arg Glu Gly Leu Leu Tyr Tyr Asn Arg Ala Leu Asp Arg Glu           
            75                  80                  85                    

aca aga tct act cac aat ctc cag gtt gca gcc ctg gac gct aat gga        402
Thr Arg Ser Thr His Asn Leu Gln Val Ala Ala Leu Asp Ala Asn Gly           
        90                  95                  100                       

att ata gtg gag ggt cca gtc cct atc acc ata aaa gtg aag gac atc        450
Ile Ile Val Glu Gly Pro Val Pro Ile Thr Ile Lys Val Lys Asp Ile           
    105                 110                 115                           

aac gac aat cga ccc acg ttt ctc cag tca aag tac gaa ggc tca gta        498
Asn Asp Asn Arg Pro Thr Phe Leu Gln Ser Lys Tyr Glu Gly Ser Val           
120                 125                 130                 135           

agg cag aac tct cgc cca gga aag ccc ttc ttg tat gtc aat gcc aca        546
Arg Gln Asn Ser Arg Pro Gly Lys Pro Phe Leu Tyr Val Asn Ala Thr           
                140                 145                 150               

gac ctg gat gat ccg gcc act ccc aat ggc cag ctt tat tac cag att        594
Asp Leu Asp Asp Pro Ala Thr Pro Asn Gly Gln Leu Tyr Tyr Gln Ile           
            155                 160                 165                   

gtc atc cag ctt ccc atg atc aac aat gtc atg tac ttt cag atc aac        642
Val Ile Gln Leu Pro Met Ile Asn Asn Val Met Tyr Phe Gln Ile Asn           
        170                 175                 180                       

aac aaa acg gga gcc atc tct ctt acc cga gag gga tct cag gaa ttg        690
Asn Lys Thr Gly Ala Ile Ser Leu Thr Arg Glu Gly Ser Gln Glu Leu           
    185                 190                 195                           

aat cct gct aag aat cct tcc tat aat ctg gtg atc tca gtg aag gac        738
Asn Pro Ala Lys Asn Pro Ser Tyr Asn Leu Val Ile Ser Val Lys Asp           
200                 205                 210                 215           

atg gga ggc cag agt gag aat tcc ttc agt gat acc aca tct gtg gat        786
Met Gly Gly Gln Ser Glu Asn Ser Phe Ser Asp Thr Thr Ser Val Asp           
                220                 225                 230               

atc ata gtg aca gag aat att tgg aaa gca cca aaa cct gtg gag atg        834
Ile Ile Val Thr Glu Asn Ile Trp Lys Ala Pro Lys Pro Val Glu Met           
            235                 240                 245                   

gtg gaa aac tca act gat cct cac ccc atc aaa atc act cag gtg cgg        882
Val Glu Asn Ser Thr Asp Pro His Pro Ile Lys Ile Thr Gln Val Arg           
        250                 255                 260                       

tgg aat gat ccc ggt gca caa tat tcc tta gtt gac aaa gag aag ctg        930
Trp Asn Asp Pro Gly Ala Gln Tyr Ser Leu Val Asp Lys Glu Lys Leu           
    265                 270                 275                           

cca aga ttc cca ttt tca att gac cag gaa gga gat att tac gtg act        978
Pro Arg Phe Pro Phe Ser Ile Asp Gln Glu Gly Asp Ile Tyr Val Thr           
280                 285                 290                 295           

cag ccc ttg gac cga gaa gaa aag gat gca tat gtt ttt tat gca gtt       1026
Gln Pro Leu Asp Arg Glu Glu Lys Asp Ala Tyr Val Phe Tyr Ala Val           
                300                 305                 310               

gca aag gat gag tac gga aaa cca ctt tca tat ccg ctg gaa att cat       1074
Ala Lys Asp Glu Tyr Gly Lys Pro Leu Ser Tyr Pro Leu Glu Ile His           
            315                 320                 325                   

gta aaa gtt aaa gat att aat gat aat cca cct aca tgt ccg tca cca       1122
Val Lys Val Lys Asp Ile Asn Asp Asn Pro Pro Thr Cys Pro Ser Pro           
        330                 335                 340                       

gta acc gta ttt gag gtc cag gag aat gaa cga ctg ggt aac agt atc       1170
Val Thr Val Phe Glu Val Gln Glu Asn Glu Arg Leu Gly Asn Ser Ile           
    345                 350                 355                           

ggg acc ctt act gca cat gac agg gat gaa gaa aat act gcc aac agt       1218
Gly Thr Leu Thr Ala His Asp Arg Asp Glu Glu Asn Thr Ala Asn Ser           
360                 365                 370                 375           

ttt cta aac tac agg att gtg gag caa act ccc aaa ctt ccc atg gat       1266
Phe Leu Asn Tyr Arg Ile Val Glu Gln Thr Pro Lys Leu Pro Met Asp           
                380                 385                 390               

gga ctc ttc cta atc caa acc tat gct gga atg tta cag tta gct aaa       1314
Gly Leu Phe Leu Ile Gln Thr Tyr Ala Gly Met Leu Gln Leu Ala Lys           
            395                 400                 405                   

cag tcc ttg aag aag caa gat act cct cag tac aac tta acg ata gag       1362
Gln Ser Leu Lys Lys Gln Asp Thr Pro Gln Tyr Asn Leu Thr Ile Glu           
        410                 415                 420                       

gtg tct gac aaa gat ttc aag acc ctt tgt ttt gtg caa atc aac gtt       1410
Val Ser Asp Lys Asp Phe Lys Thr Leu Cys Phe Val Gln Ile Asn Val           
    425                 430                 435                           

att gat atc aat gat cag atc ccc atc ttt gaa aaa tca gat tat gga       1458
Ile Asp Ile Asn Asp Gln Ile Pro Ile Phe Glu Lys Ser Asp Tyr Gly           
440                 445                 450                 455           

aac ctg act ctt gct gaa gac aca aac att ggg tcc acc atc tta acc       1506
Asn Leu Thr Leu Ala Glu Asp Thr Asn Ile Gly Ser Thr Ile Leu Thr           
                460                 465                 470               

atc cag gcc act gat gct gat gag cca ttt act ggg agt tct aaa att       1554
Ile Gln Ala Thr Asp Ala Asp Glu Pro Phe Thr Gly Ser Ser Lys Ile           
            475                 480                 485                   

ctg tat cat atc ata aag gga gac agt gag gga cgc ctg ggg gtt gac       1602
Leu Tyr His Ile Ile Lys Gly Asp Ser Glu Gly Arg Leu Gly Val Asp           
        490                 495                 500                       

aca gat ccc cat acc aac acc gga tat gtc ata att aaa aag cct ctt       1650
Thr Asp Pro His Thr Asn Thr Gly Tyr Val Ile Ile Lys Lys Pro Leu           
    505                 510                 515                           

gat ttt gaa aca gca gct gtt tcc aac att gtg ttc aaa gca gaa aat       1698
Asp Phe Glu Thr Ala Ala Val Ser Asn Ile Val Phe Lys Ala Glu Asn           
520                 525                 530                 535           

cct gag cct cta gtg ttt ggt gtg aag tac aat gca agt tct ttt gcc       1746
Pro Glu Pro Leu Val Phe Gly Val Lys Tyr Asn Ala Ser Ser Phe Ala           
                540                 545                 550               

aag ttc acg ctt att gtg aca gat gtg aat gaa gca cct caa ttt tcc       1794
Lys Phe Thr Leu Ile Val Thr Asp Val Asn Glu Ala Pro Gln Phe Ser           
            555                 560                 565                   

caa cac gta ttc caa gcg aaa gtc agt gag gat gta gct ata ggc act       1842
Gln His Val Phe Gln Ala Lys Val Ser Glu Asp Val Ala Ile Gly Thr           
        570                 575                 580                       

aaa gtg ggc aat gtg act gcc aag gat cca gaa ggt ctg gac ata agc       1890
Lys Val Gly Asn Val Thr Ala Lys Asp Pro Glu Gly Leu Asp Ile Ser           
    585                 590                 595                           

tat tca ctg agg gga gac aca aga ggt tgg ctt aaa att gac cac gtg       1938
Tyr Ser Leu Arg Gly Asp Thr Arg Gly Trp Leu Lys Ile Asp His Val           
600                 605                 610                 615           

act ggt gag atc ttt agt gtg gct cca ttg gac aga gaa gcc gga agt       1986
Thr Gly Glu Ile Phe Ser Val Ala Pro Leu Asp Arg Glu Ala Gly Ser           
                620                 625                 630               

cca tat cgg gta caa gtg gtg gcc aca gaa gta ggg ggg tct tcc ttg       2034
Pro Tyr Arg Val Gln Val Val Ala Thr Glu Val Gly Gly Ser Ser Leu           
            635                 640                 645                   

agc tct gtg tca gag ttc cac ctg atc ctt atg gat gtg aat gac aac       2082
Ser Ser Val Ser Glu Phe His Leu Ile Leu Met Asp Val Asn Asp Asn           
        650                 655                 660                       

cct ccc agg cta gcc aag gac tac acg ggc ttg ttc ttc tgc cat ccc       2130
Pro Pro Arg Leu Ala Lys Asp Tyr Thr Gly Leu Phe Phe Cys His Pro           
    665                 670                 675                           

ctc agt gca cct gga agt ctc att ttc gag gct act gat gat gat cag       2178
Leu Ser Ala Pro Gly Ser Leu Ile Phe Glu Ala Thr Asp Asp Asp Gln           
680                 685                 690                 695           

cac tta ttt cgg ggt ccc cat ttt aca ttt tcc ctc ggc agt gga agc       2226
His Leu Phe Arg Gly Pro His Phe Thr Phe Ser Leu Gly Ser Gly Ser           
                700                 705                 710               

tta caa aac gac tgg gaa gtt tcc aaa atc aat ggt act cat gcc cga       2274
Leu Gln Asn Asp Trp Glu Val Ser Lys Ile Asn Gly Thr His Ala Arg           
            715                 720                 725                   

ctg tct acc agg cac aca gag ttt gag gag agg gag tat gtc gtc ttg       2322
Leu Ser Thr Arg His Thr Glu Phe Glu Glu Arg Glu Tyr Val Val Leu           
        730                 735                 740                       

atc cgc atc aat gat ggg ggt cgg cca ccc ttg gaa ggc att gtt tct       2370
Ile Arg Ile Asn Asp Gly Gly Arg Pro Pro Leu Glu Gly Ile Val Ser           
    745                 750                 755                           

tta cca gtt aca ttc tgc agt tgt gtg gaa gga agt tgt ttc cgg cca       2418
Leu Pro Val Thr Phe Cys Ser Cys Val Glu Gly Ser Cys Phe Arg Pro           
760                 765                 770                 775           

gca ggt cac cag act ggg ata ccc act gtg ggc atg gca gtt ggt ata       2466
Ala Gly His Gln Thr Gly Ile Pro Thr Val Gly Met Ala Val Gly Ile           
                780                 785                 790               

ctg ctg acc acc ctt ctg gtg att ggt ata att tta gca gtt gtg ttt       2514
Leu Leu Thr Thr Leu Leu Val Ile Gly Ile Ile Leu Ala Val Val Phe           
            795                 800                 805                   

atc cgc ata aag aag gat aaa ggc aaa gat aat gtt gaa agt gct caa       2562
Ile Arg Ile Lys Lys Asp Lys Gly Lys Asp Asn Val Glu Ser Ala Gln           
        810                 815                 820                       

gca tct gaa gtc aaa cct ctg aga agc tga atttgaaaag gaatgtttga         2612
Ala Ser Glu Val Lys Pro Leu Arg Ser                                       
    825                 830                                               

atttatatag caagtgctat ttcagcaaca accatctcat cctattactt ttcatctaac     2672

gtgcattata attttttaaa cagatattcc ctcttgtcct ttaatatttg ctaaatattt     2732

cttttttgag gtggagtctt gctctgtcgc ccaggctgga gtacagtggt gtgatcccag     2792

ctcactgcaa cctccgcctc ctgggttcac atgattctcc tgcctcagct tcctaagtag     2852

ctgggtttac aggcacccac caccatgccc agctaatttt tgtattttta atagagacgg     2912

ggtttcgcca tttggccagg ctggtcttga actcctgacg tcaagtgatc tgcctgcctt     2972

ggtctcccaa tacaggcatg aaccactgca cccacctact tagatatttc atgtgctata     3032

gacattagag agatttttca tttttccatg acatttttcc tctctgcaaa tggcttagct     3092

acttgtgttt ttcccttttg gggcaagaca gactcattaa atattctgta cattttttct     3152

ttatcaagga gatatatcag tgttgtctca tagaactgcc tggattccat ttatgttttt     3212

tctgattcca tcctgtgtcc ccttcatcct tgactccttt ggtatttcac tgaatttcaa     3272

acatttgtca gagaagaaaa acgtgaggac tcaggaaaaa taaataaata aaagaacagc     3332

cttttccctt agtattaaca gaaatgtttc tgtgtcatta accatcttta atcaatgtga     3392

catgttgctc tttggctgaa attcttcaac ttggaaatga cacagaccca cagaaggtgt     3452

tcaaacacaa cctactctgc aaaccttggt aaaggaacca gtcagctggc cagatttcct     3512

cactacctgc catgcataca tgctgcgcat gttttcttca ttcgtatgtt agtaaagttt     3572

tggttattat atatttaaca tgtggaagaa aacaagacat gaaaagagtg gtgacaaatc     3632

aagaataaac actggttgta gtcagttttg tttgttga                             3670


<210>  8
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Thr Asp Leu Asp Asp Pro Ala Thr Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Thr Gly Ala Ile Ser Leu Thr 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Thr Thr Ser Val Asp Ile Ile Val Thr Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Thr Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Thr Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Thr Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Thr Cys Pro Ser Pro Val Thr Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Thr Leu Thr Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Thr Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Thr Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro 
                405                 410                 415     


Gln Tyr Asn Leu Thr Ile Glu Val Ser Asp Lys Asp Phe Lys Thr Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn 
    450                 455                 460                 


Ile Gly Ser Thr Ile Leu Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Thr Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Thr Asp Pro His Thr Asn Thr Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Thr Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Thr Leu Ile Val Thr Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Thr Lys Val Gly Asn Val Thr Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Thr Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Thr 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Thr Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Thr 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Thr His Ala Arg Leu Ser Thr Arg His Thr Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Thr Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Thr Gly Ile Pro Thr 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Thr Thr Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210>  9
<211>  3355
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (62)..(847)

<400>  9
acaccttcgg cagcaggagg gcggcagctt ctcgcaggcg gcagggcggg cggccaggat       60

c atg tcc acc acc aca tgc caa gtg gtg gcg ttc ctc ctg tcc atc ctg      109
  Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu         
  1               5                   10                  15              

ggg ctg gcc ggc tgc atc gcg gcc acc ggg atg gac atg tgg agc acc        157
Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr           
            20                  25                  30                    

cag gac ctg tac gac aac ccc gtc acc tcc gtg ttc cag tac gaa ggg        205
Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly           
        35                  40                  45                        

ctc tgg agg agc tgc gtg agg cag agt tca ggc ttc acc gaa tgc agg        253
Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg           
    50                  55                  60                            

ccc tat ttc acc atc ctg gga ctt cca gcc atg ctg cag gca gtg cga        301
Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg           
65                  70                  75                  80            

gcc ctg atg atc gta ggc atc gtc ctg ggt gcc att ggc ctc ctg gta        349
Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val           
                85                  90                  95                

tcc atc ttt gcc ctg aaa tgc atc cgc att ggc agc atg gag gac tct        397
Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser           
            100                 105                 110                   

gcc aaa gcc aac atg aca ctg acc tcc ggg atc atg ttc att gtc tca        445
Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser           
        115                 120                 125                       

ggt ctt tgt gca att gct gga gtg tct gtg ttt gcc aac atg ctg gtg        493
Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val           
    130                 135                 140                           

act aac ttc tgg atg tcc aca gct aac atg tac acc ggc atg ggt ggg        541
Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly           
145                 150                 155                 160           

atg gtg cag act gtt cag acc agg tac aca ttt ggt gcg gct ctg ttc        589
Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe           
                165                 170                 175               

gtg ggc tgg gtc gct gga ggc ctc aca cta att ggg ggt gtg atg atg        637
Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met           
            180                 185                 190                   

tgc atc gcc tgc cgg ggc ctg gca cca gaa gaa acc aac tac aaa gcc        685
Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala           
        195                 200                 205                       

gtt tct tat cat gcc tca ggc cac agt gtt gcc tac aag cct gga ggc        733
Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly           
    210                 215                 220                           

ttc aag gcc agc act ggc ttt ggg tcc aac acc aaa aac aag aag ata        781
Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile           
225                 230                 235                 240           

tac gat gga ggt gcc cgc aca gag gac gag gta caa tct tat cct tcc        829
Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser           
                245                 250                 255               

aag cac gac tat gtg taa tgctctaaga cctctcagca cgggcggaag               877
Lys His Asp Tyr Val                                                       
            260                                                           

aaactcccgg agagctcacc caaaaaacaa ggagatccca tctagatttc ttcttgcttt      937

tgactcacag ctggaagtta gaaaagcctc gatttcatct ttggagaggc caaatggtct      997

tagcctcagt ctctgtctct aaatattcca ccataaaaca gctgagttat ttatgaatta     1057

gaggctatag ctcacatttt caatcctcta tttctttttt taaatataac tttctactct     1117

gatgagagaa tgtggtttta atctctctct cacattttga tgatttagac agactccccc     1177

tcttcctcct agtcaataaa cccattgatg atctatttcc cagcttatcc ccaagaaaac     1237

ttttgaaagg aaagagtaga cccaaagatg ttattttctg ctgtttgaat tttgtctccc     1297

cacccccaac ttggctagta ataaacactt actgaagaag aagcaataag agaaagatat     1357

ttgtaatctc tccagcccat gatctcggtt ttcttacact gtgatcttaa aagttaccaa     1417

accaaagtca ttttcagttt gaggcaacca aacctttcta ctgctgttga catcttctta     1477

ttacagcaac accattctag gagtttcctg agctctccac tggagtcctc tttctgtcgc     1537

gggtcagaaa ttgtccctag atgaatgaga aaattatttt ttttaattta agtcctaaat     1597

atagttaaaa taaataatgt tttagtaaaa tgatacacta tctctgtgaa atagcctcac     1657

ccctacatgt ggatagaagg aaatgaaaaa ataattgctt tgacattgtc tatatggtac     1717

tttgtaaagt catgcttaag tacaaattcc atgaaaagct cactgatcct aattctttcc     1777

ctttgaggtc tctatggctc tgattgtaca tgatagtaag tgtaagccat gtaaaaagta     1837

aataatgtct gggcacagtg gctcacgcct gtaatcctag cactttggga ggctgaggag     1897

gaaggatcac ttgagcccag aagttcgaga ctagcctggg caacatggag aagccctgtc     1957

tctacaaaat acagagagaa aaaatcagcc agtcatggtg gcctacacct gtagtcccag     2017

cattccggga ggctgaggtg ggaggatcac ttgagcccag ggaggttggg gctgcagtga     2077

gccatgatca caccactgca ctccagccag gtgacatagc gagatcctgt ctaaaaaaat     2137

aaaaaataaa taatggaaca cagcaagtcc taggaagtag gttaaaacta attctttaaa     2197

aaaaaaaaaa agttgagcct gaattaaatg taatgtttcc aagtgacagg tatccacatt     2257

tgcatggtta caagccactg ccagttagca gtagcacttt cctggcactg tggtcggttt     2317

tgttttgttt tgctttgttt agagacgggg tctcactttc caggctggcc tcaaactcct     2377

gcactcaagc aattcttcta ccctggcctc ccaagtagct ggaattacag gtgtgcgcca     2437

tcacaactag ctggtggtca gttttgttac tctgagagct gttcacttct ctgaattcac     2497

ctagagtggt tggaccatca gatgtttggg caaaactgaa agctctttgc aaccacacac     2557

cttccctgag cttacatcac tgcccttttg agcagaaagt ctaaattcct tccaagacag     2617

tagaattcca tcccagtacc aaagccagat aggcccccta ggaaactgag gtaagagcag     2677

tctctaaaaa ctacccacag cagcattggt gcaggggaac ttggccatta ggttattatt     2737

tgagaggaaa gtcctcacat caatagtaca tatgaaagtg acctccaagg ggattggtga     2797

atactcataa ggatcttcag gctgaacaga ctatgtctgg ggaaagaacg gattatgccc     2857

cattaaataa caagttgtgt tcaagagtca gagcagtgag ctcagaggcc cttctcactg     2917

agacagcaac atttaaacca aaccagagga agtatttgtg gaactcactg cctcagtttg     2977

ggtaaaggat gagcagacaa gtcaactaaa gaaaaaagaa aagcaaggag gagggttgag     3037

caatctagag catggagttt gttaagtgct ctctggattt gagttgaaga gcatccattt     3097

gagttgaagg ccacagggca caatgagctc tcccttctac caccagaaag tccctggtca     3157

ggtctcaggt agtgcggtgt ggctcagctg ggtttttaat tagcgcattc tctatccaac     3217

atttaattgt ttgaaagcct ccatatagtt agattgtgct ttgtaatttt gttgttgttg     3277

ctctatctta ttgtatatgc attgagtatt aacctgaatg ttttgttact taaatattaa     3337

aaacactgtt atcctaca                                                   3355


<210>  10
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  11
<211>  1146
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (158)..(838)

<400>  11
cattagcata acccttcctc aggaagagtg agattttata tttgacaata aagtgttaga       60

ctccatttct aaataccaga cttcaaaaga taaggttcaa aagtgttata agaagatatt      120

cctttttttg tcctagagaa cttattttcc tgtgaaa atg cct acc aca aag aag       175
                                         Met Pro Thr Thr Lys Lys          
                                         1               5                

aca ttg atg ttc tta tca agc ttt ttc acc agc ctt ggg tcc ttc att        223
Thr Leu Met Phe Leu Ser Ser Phe Phe Thr Ser Leu Gly Ser Phe Ile           
            10                  15                  20                    

gta att tgc tct att ctt ggg aca caa gca tgg atc acc agt aca att        271
Val Ile Cys Ser Ile Leu Gly Thr Gln Ala Trp Ile Thr Ser Thr Ile           
        25                  30                  35                        

gct gtt aga gac tct gct tca aat ggg agc att ttc atc act tac gga        319
Ala Val Arg Asp Ser Ala Ser Asn Gly Ser Ile Phe Ile Thr Tyr Gly           
    40                  45                  50                            

ctt ttt cgt ggg gag agt agt gaa gaa ttg agt cac gga ctt gca gaa        367
Leu Phe Arg Gly Glu Ser Ser Glu Glu Leu Ser His Gly Leu Ala Glu           
55                  60                  65                  70            

cca aag aaa aag ttt gca gtt tta gag ata ctg aat aat tct tcc caa        415
Pro Lys Lys Lys Phe Ala Val Leu Glu Ile Leu Asn Asn Ser Ser Gln           
                75                  80                  85                

aaa act ctg cat tcg gtg act atc ctg ttc ctg gtc ctg agt ttg atc        463
Lys Thr Leu His Ser Val Thr Ile Leu Phe Leu Val Leu Ser Leu Ile           
            90                  95                  100                   

acg tcg ctg ctg agc tct ggg ttt acc ttc tac aac agc atc agc aac        511
Thr Ser Leu Leu Ser Ser Gly Phe Thr Phe Tyr Asn Ser Ile Ser Asn           
        105                 110                 115                       

cct tac cag aca ttc ctg ggg ccg acg ggg gtg tac acc tgg aac ggg        559
Pro Tyr Gln Thr Phe Leu Gly Pro Thr Gly Val Tyr Thr Trp Asn Gly           
    120                 125                 130                           

ctc ggt gca tcc ttc gtt ttt gtg acc atg ata ctg ttt gtg gcg aac        607
Leu Gly Ala Ser Phe Val Phe Val Thr Met Ile Leu Phe Val Ala Asn           
135                 140                 145                 150           

acg cag tcc aac caa ctc tcc gaa gag ttg ttc caa atg ctt tac ccg        655
Thr Gln Ser Asn Gln Leu Ser Glu Glu Leu Phe Gln Met Leu Tyr Pro           
                155                 160                 165               

gca acc acc agt aaa gga acg acc cac agt tac gga tac tcg ttc tgg        703
Ala Thr Thr Ser Lys Gly Thr Thr His Ser Tyr Gly Tyr Ser Phe Trp           
            170                 175                 180                   

ctc ata ctg ctc gtc att ctt cta aat ata gtc act gta acc atc atc        751
Leu Ile Leu Leu Val Ile Leu Leu Asn Ile Val Thr Val Thr Ile Ile           
        185                 190                 195                       

att ttc tac cag aag gcc aga tac cag cgg aag cag gag cag aga aag        799
Ile Phe Tyr Gln Lys Ala Arg Tyr Gln Arg Lys Gln Glu Gln Arg Lys           
    200                 205                 210                           

cca atg gaa tat gct cca agg gac gga att tta ttc tga attctctttc         848
Pro Met Glu Tyr Ala Pro Arg Asp Gly Ile Leu Phe                           
215                 220                 225                               

atctcatttt ggcgttgcat ctattgtaca tcagccctga gtagtaactg gttagcttct      908

ctggacaatt cagcatggta acgtgactgt catctgtgac agcatttgtg tttcatgaca      968

ctgtgttctt cattgatgct gtactcctga aaatttttcc cacaaggttg gggaaatgaa     1028

tgggaaatgt cgctggtctg tgtggtattc aaagcagtag tatcatgatg agcgtaacga     1088

cccttctgac ctggtctcac gatctgaaat aataaaaggc tgtgtcatgt ttcttttc       1146


<210>  12
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Thr Thr Lys Lys Thr Leu Met Phe Leu Ser Ser Phe Phe Thr 
1               5                   10                  15      


Ser Leu Gly Ser Phe Ile Val Ile Cys Ser Ile Leu Gly Thr Gln Ala 
            20                  25                  30          


Trp Ile Thr Ser Thr Ile Ala Val Arg Asp Ser Ala Ser Asn Gly Ser 
        35                  40                  45              


Ile Phe Ile Thr Tyr Gly Leu Phe Arg Gly Glu Ser Ser Glu Glu Leu 
    50                  55                  60                  


Ser His Gly Leu Ala Glu Pro Lys Lys Lys Phe Ala Val Leu Glu Ile 
65                  70                  75                  80  


Leu Asn Asn Ser Ser Gln Lys Thr Leu His Ser Val Thr Ile Leu Phe 
                85                  90                  95      


Leu Val Leu Ser Leu Ile Thr Ser Leu Leu Ser Ser Gly Phe Thr Phe 
            100                 105                 110         


Tyr Asn Ser Ile Ser Asn Pro Tyr Gln Thr Phe Leu Gly Pro Thr Gly 
        115                 120                 125             


Val Tyr Thr Trp Asn Gly Leu Gly Ala Ser Phe Val Phe Val Thr Met 
    130                 135                 140                 


Ile Leu Phe Val Ala Asn Thr Gln Ser Asn Gln Leu Ser Glu Glu Leu 
145                 150                 155                 160 


Phe Gln Met Leu Tyr Pro Ala Thr Thr Ser Lys Gly Thr Thr His Ser 
                165                 170                 175     


Tyr Gly Tyr Ser Phe Trp Leu Ile Leu Leu Val Ile Leu Leu Asn Ile 
            180                 185                 190         


Val Thr Val Thr Ile Ile Ile Phe Tyr Gln Lys Ala Arg Tyr Gln Arg 
        195                 200                 205             


Lys Gln Glu Gln Arg Lys Pro Met Glu Tyr Ala Pro Arg Asp Gly Ile 
    210                 215                 220                 


Leu Phe 
225     


<210>  13
<211>  2214
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (105)..(1295)

<400>  13
agactgggct gggcaggtct gagagttagg gaaagtccgt tcccactgcc ctcggggaga       60

gaagaaagga gggggcaagg gagaagctgc tggtcggact caca atg aaa acg ctc       116
                                                 Met Lys Thr Leu          
                                                 1                        

ctt ctt ttg ctg ctg gtg ctc ctg gag ctg gga gag gcc caa gga tcc        164
Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu Ala Gln Gly Ser           
5                   10                  15                  20            

ctt cac agg gtg ccc ctc agg agg cat ccg tcc ctc aag aag aag ctg        212
Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu Lys Lys Lys Leu           
                25                  30                  35                

cgg gca cgg agc cag ctc tct gag ttc tgg aaa tcc cat aat ttg gac        260
Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser His Asn Leu Asp           
            40                  45                  50                    

atg atc cag ttc acc gag tcc tgc tca atg gac cag agt gcc aag gaa        308
Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln Ser Ala Lys Glu           
        55                  60                  65                        

ccc ctc atc aac tac ttg gat atg gaa tac ttc ggc act atc tcc att        356
Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile Ser Ile           
    70                  75                  80                            

ggc tcc cca cca cag aac ttc act gtc atc ttc gac act ggc tcc tcc        404
Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp Thr Gly Ser Ser           
85                  90                  95                  100           

aac ctc tgg gtc ccc tct gtg tac tgc act agc cca gcc tgc aag acg        452
Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro Ala Cys Lys Thr           
                105                 110                 115               

cac agc agg ttc cag cct tcc cag tcc agc aca tac agc cag cca ggt        500
His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr Ser Gln Pro Gly           
            120                 125                 130                   

caa tct ttc tcc att cag tat gga acc ggg agc ttg tcc ggg atc att        548
Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu Ser Gly Ile Ile           
        135                 140                 145                       

gga gcc gac caa gtc tct gtg gaa gga cta acc gtg gtt ggc cag cag        596
Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val Val Gly Gln Gln           
    150                 155                 160                           

ttt gga gaa agt gtc aca gag cca ggc cag acc ttt gtg gat gca gag        644
Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe Val Asp Ala Glu           
165                 170                 175                 180           

ttt gat gga att ctg ggc ctg gga tac ccc tcc ttg gct gtg gga gga        692
Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu Ala Val Gly Gly           
                185                 190                 195               

gtg act cca gta ttt gac aac atg atg gct cag aac ctg gtg gac ttg        740
Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn Leu Val Asp Leu           
            200                 205                 210                   

ccg atg ttt tct gtc tac atg agc agt aac cca gaa ggt ggt gcg ggg        788
Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu Gly Gly Ala Gly           
        215                 220                 225                       

agc gag ctg att ttt gga ggc tac gac cac tcc cat ttc tct ggg agc        836
Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His Phe Ser Gly Ser           
    230                 235                 240                           

ctg aat tgg gtc cca gtc acc aag caa gct tac tgg cag att gca ctg        884
Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp Gln Ile Ala Leu           
245                 250                 255                 260           

gat aac atc cag gtg gga ggc act gtt atg ttc tgc tcc gag ggc tgc        932
Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys Ser Glu Gly Cys           
                265                 270                 275               

cag gcc att gtg gac aca ggg act tcc ctc atc act ggc cct tcc gac        980
Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr Gly Pro Ser Asp           
            280                 285                 290                   

aag att aag cag ctg caa aac gcc att ggg gca gcc ccc gtg gat gga       1028
Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala Pro Val Asp Gly           
        295                 300                 305                       

gaa tat gct gtg gag tgt gcc aac ctt aac gtc atg ccg gat gtc acc       1076
Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met Pro Asp Val Thr           
    310                 315                 320                           

ttc acc att aac gga gtc ccc tat acc ctc agc cca act gcc tac acc       1124
Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro Thr Ala Tyr Thr           
325                 330                 335                 340           

cta ctg gac ttc gtg gat gga atg cag ttc tgc agc agt ggc ttt caa       1172
Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser Ser Gly Phe Gln           
                345                 350                 355               

gga ctt gac atc cac cct cca gct ggg ccc ctc tgg atc ctg ggg gat       1220
Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp Ile Leu Gly Asp           
            360                 365                 370                   

gtc ttc att cga cag ttt tac tca gtc ttt gac cgt ggg aat aac cgt       1268
Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg Gly Asn Asn Arg           
        375                 380                 385                       

gtg gga ctg gcc cca gca gtc ccc taa ggaggggcct tgtgtctgtg             1315
Val Gly Leu Ala Pro Ala Val Pro                                           
    390                 395                                               

cctgcctgtc tgacagacct tgaatatgtt aggctggggc attctttaca cctacaaaaa     1375

gttattttcc agagaatgta gctgtttcca gggttgcaac ttgaattaag accaaacaga     1435

acatgagaat acacacacac acacacatat acacacacac acacttcaca catacacacc     1495

actcccacca ccgtcatgat ggaggaatta cgttatacat tcatattttg tattgatttt     1555

tgattatgaa aatcaaaaat tttcacattt gattatgaaa atctccaaac atatgcacaa     1615

gcagagatca tggtataata aatccctttg caactccact cagccctgac aacccatcca     1675

cacacggcca ggcctgttta tctacactgc tgcccactcc tctctccagc tccacatgct     1735

gtacctggat cattctgaag caaattccga gcattacatc attttgtcca taaatatttc     1795

taacatcctt aaatatacaa tcggaattca agcatctccc attgtcccac aaatgtttgg     1855

ctgtttttgt agttggattg tttgtattag gattcaagca aggcccatat attgcattta     1915

tttgaaatgt ctgtaagtct ctttccatct acagagttta gcacatttga acgttgctgg     1975

ttgaaatccc gaggtgtcat ttgacatggt tctctgaact tatctttcct ataaaatggt     2035

agttagatct ggaggtctga ttttgtggca aaaatacttc ctaggtggtg ctgggtactt     2095

cttgttgcat cctgtcagga ggcagataat gctggtgcct ctctattggt aatgttaaga     2155

ctgctgggtg ggtttggagt tcttggcttt aatcattcat tacaaagttc agcatttta      2214


<210>  14
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys 
            260                 265                 270         


Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr 
        275                 280                 285             


Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala 
    290                 295                 300                 


Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met 
305                 310                 315                 320 


Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro 
                325                 330                 335     


Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser 
            340                 345                 350         


Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp 
        355                 360                 365             


Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg 
    370                 375                 380                 


Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val Pro 
385                 390                 395     


<210>  15
<211>  6128
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (370)..(2697)

<400>  15
gggcctgcct gccagctagc cggagccgcg ggtgagcgcg gcgagcggcg accctggtga       60

ggagcgcggc gcgggaggca cgttccttag ctccgccgcg gccgtcctcc gcggctcgag      120

gactccgctt ccttccctcc cctcccctgc gctccggcct ggggtctcgg cgcggggagc      180

ggagggaagg gacgaaggag gagtaggtga aagcggggtg aggggcggaa gggtcccggc      240

gcggggtgag gcgagggctg cctcttgttc tcccgccgct gccgccgtct cctggtcggg      300

tgccgcggcc agaggcgcgc ggggctgccg aggcacccgc actatgcagg cagactgccg      360

gccgccgcg atg gcg agc cgg gcg gtg gtg aga gcc agg cgc tgc ccg cag      411
          Met Ala Ser Arg Ala Val Val Arg Ala Arg Arg Cys Pro Gln         
          1               5                   10                          

tgt ccc caa gtc cgg gcc gcg gcc gcc gcc ccc gcc tgg gcc gcg ctc        459
Cys Pro Gln Val Arg Ala Ala Ala Ala Ala Pro Ala Trp Ala Ala Leu           
15                  20                  25                  30            

ccc ctc tcc cgc tcc ctc cct ccc tgc tcc aac tcc tcc tcc ttc tcc        507
Pro Leu Ser Arg Ser Leu Pro Pro Cys Ser Asn Ser Ser Ser Phe Ser           
                35                  40                  45                

atg cct ctg ttc ctc ctg ctc tta ctt gtc ctg ctc ctg ctg ctc gag        555
Met Pro Leu Phe Leu Leu Leu Leu Leu Val Leu Leu Leu Leu Leu Glu           
            50                  55                  60                    

gac gct gga gcc cag caa ggt gat gga tgt gga cac act gta cta ggc        603
Asp Ala Gly Ala Gln Gln Gly Asp Gly Cys Gly His Thr Val Leu Gly           
        65                  70                  75                        

cct gag agt gga acc ctt aca tcc ata aac tac cca cag acc tat ccc        651
Pro Glu Ser Gly Thr Leu Thr Ser Ile Asn Tyr Pro Gln Thr Tyr Pro           
    80                  85                  90                            

aac agc act gtt tgt gaa tgg gag atc cgt gta aag atg gga gag aga        699
Asn Ser Thr Val Cys Glu Trp Glu Ile Arg Val Lys Met Gly Glu Arg           
95                  100                 105                 110           

gtt cgc atc aaa ttt ggt gac ttt gac att gaa gat tct gat tct tgt        747
Val Arg Ile Lys Phe Gly Asp Phe Asp Ile Glu Asp Ser Asp Ser Cys           
                115                 120                 125               

cac ttt aat tac ttg aga att tat aat gga att gga gtc agc aga act        795
His Phe Asn Tyr Leu Arg Ile Tyr Asn Gly Ile Gly Val Ser Arg Thr           
            130                 135                 140                   

gaa ata ggc aaa tac tgt ggt ctg ggg ttg caa atg aac cat tca att        843
Glu Ile Gly Lys Tyr Cys Gly Leu Gly Leu Gln Met Asn His Ser Ile           
        145                 150                 155                       

gaa tca aaa ggc aat gaa atc aca ttg ctg ttc atg agt gga atc cat        891
Glu Ser Lys Gly Asn Glu Ile Thr Leu Leu Phe Met Ser Gly Ile His           
    160                 165                 170                           

gtt tct gga cgc gga ttt ttg gcc tca tac tct gtt ata gat aaa caa        939
Val Ser Gly Arg Gly Phe Leu Ala Ser Tyr Ser Val Ile Asp Lys Gln           
175                 180                 185                 190           

gat cta att act tgt ttg gac act gca tcc aat ttt ttg gaa cct gag        987
Asp Leu Ile Thr Cys Leu Asp Thr Ala Ser Asn Phe Leu Glu Pro Glu           
                195                 200                 205               

ttc agt aag tac tgc cca gct ggt tgt ctg ctt cct ttt gct gag ata       1035
Phe Ser Lys Tyr Cys Pro Ala Gly Cys Leu Leu Pro Phe Ala Glu Ile           
            210                 215                 220                   

tct gga aca att cct cat gga tat aga gat tcc tcg cca ttg tgc atg       1083
Ser Gly Thr Ile Pro His Gly Tyr Arg Asp Ser Ser Pro Leu Cys Met           
        225                 230                 235                       

gct ggt gtg cat gca gga gta gtg tca aac acg ttg ggc ggc caa atc       1131
Ala Gly Val His Ala Gly Val Val Ser Asn Thr Leu Gly Gly Gln Ile           
    240                 245                 250                           

agt gtt gta att agt aaa ggt atc ccc tat tat gaa agt tct ttg gct       1179
Ser Val Val Ile Ser Lys Gly Ile Pro Tyr Tyr Glu Ser Ser Leu Ala           
255                 260                 265                 270           

aac aac gtc aca tct gtg gtg gga cac tta tct aca agt ctt ttt aca       1227
Asn Asn Val Thr Ser Val Val Gly His Leu Ser Thr Ser Leu Phe Thr           
                275                 280                 285               

ttt aag aca agt gga tgt tat gga aca ctg ggg atg gag tct ggt gtg       1275
Phe Lys Thr Ser Gly Cys Tyr Gly Thr Leu Gly Met Glu Ser Gly Val           
            290                 295                 300                   

atc gcg gat cct caa ata aca gca tca tct gtg ctg gag tgg act gac       1323
Ile Ala Asp Pro Gln Ile Thr Ala Ser Ser Val Leu Glu Trp Thr Asp           
        305                 310                 315                       

cac aca ggg caa gag aac agt tgg aaa ccc aaa aaa gcc agg ctg aaa       1371
His Thr Gly Gln Glu Asn Ser Trp Lys Pro Lys Lys Ala Arg Leu Lys           
    320                 325                 330                           

aaa cct gga ccg cct tgg gct gct ttt gcc act gat gaa tac cag tgg       1419
Lys Pro Gly Pro Pro Trp Ala Ala Phe Ala Thr Asp Glu Tyr Gln Trp           
335                 340                 345                 350           

tta caa ata gat ttg aat aag gaa aag aaa ata aca ggc att ata acc       1467
Leu Gln Ile Asp Leu Asn Lys Glu Lys Lys Ile Thr Gly Ile Ile Thr           
                355                 360                 365               

act gga tcc acc atg gtg gag cac aat tac tat gtg tct gcc tac aga       1515
Thr Gly Ser Thr Met Val Glu His Asn Tyr Tyr Val Ser Ala Tyr Arg           
            370                 375                 380                   

atc ctg tac agt gat gat ggg cag aaa tgg act gtg tac aga gag cct       1563
Ile Leu Tyr Ser Asp Asp Gly Gln Lys Trp Thr Val Tyr Arg Glu Pro           
        385                 390                 395                       

ggt gtg gag caa gat aag ata ttt caa gga aac aaa gat tat cac cag       1611
Gly Val Glu Gln Asp Lys Ile Phe Gln Gly Asn Lys Asp Tyr His Gln           
    400                 405                 410                           

gat gtg cgt aat aac ttt ttg cca cca att att gca cgt ttt att aga       1659
Asp Val Arg Asn Asn Phe Leu Pro Pro Ile Ile Ala Arg Phe Ile Arg           
415                 420                 425                 430           

gtg aat cct acc caa tgg cag cag aaa att gcc atg aaa atg gag ctg       1707
Val Asn Pro Thr Gln Trp Gln Gln Lys Ile Ala Met Lys Met Glu Leu           
                435                 440                 445               

ctc gga tgt cag ttt att cct aaa ggt cgt cct cca aaa ctt act caa       1755
Leu Gly Cys Gln Phe Ile Pro Lys Gly Arg Pro Pro Lys Leu Thr Gln           
            450                 455                 460                   

cct cca cct cct cgg aac agc aat gac ctc aaa aac act aca gcc cct       1803
Pro Pro Pro Pro Arg Asn Ser Asn Asp Leu Lys Asn Thr Thr Ala Pro           
        465                 470                 475                       

cca aaa ata gcc aaa ggt cgt gcc cca aaa ttt acg caa cca cta caa       1851
Pro Lys Ile Ala Lys Gly Arg Ala Pro Lys Phe Thr Gln Pro Leu Gln           
    480                 485                 490                           

cct cgc agt agc aat gaa ttt cct gca cag aca gaa caa aca act gcc       1899
Pro Arg Ser Ser Asn Glu Phe Pro Ala Gln Thr Glu Gln Thr Thr Ala           
495                 500                 505                 510           

agt cct gat atc aga aat act acc gta act cca aat gta acc aaa gat       1947
Ser Pro Asp Ile Arg Asn Thr Thr Val Thr Pro Asn Val Thr Lys Asp           
                515                 520                 525               

gta gcg ctg gct gca gtt ctt gtc cct gtg ctg gtc atg gtc ctc act       1995
Val Ala Leu Ala Ala Val Leu Val Pro Val Leu Val Met Val Leu Thr           
            530                 535                 540                   

act ctc att ctc ata tta gtg tgt gct tgg cac tgg aga aac aga aag       2043
Thr Leu Ile Leu Ile Leu Val Cys Ala Trp His Trp Arg Asn Arg Lys           
        545                 550                 555                       

aaa aaa act gaa ggc acc tat gac tta cct tac tgg gac cgg gca ggt       2091
Lys Lys Thr Glu Gly Thr Tyr Asp Leu Pro Tyr Trp Asp Arg Ala Gly           
    560                 565                 570                           

tgg tgg aaa gga atg aag cag ttt ctt cct gca aaa gca gtg gac cat       2139
Trp Trp Lys Gly Met Lys Gln Phe Leu Pro Ala Lys Ala Val Asp His           
575                 580                 585                 590           

gag gaa acc cca gtt cgc tat agc agc agc gaa gtt aat cac ctg agt       2187
Glu Glu Thr Pro Val Arg Tyr Ser Ser Ser Glu Val Asn His Leu Ser           
                595                 600                 605               

cca aga gaa gtc acc aca gtg ctg cag gct gac tct gca gag tat gct       2235
Pro Arg Glu Val Thr Thr Val Leu Gln Ala Asp Ser Ala Glu Tyr Ala           
            610                 615                 620                   

cag cca ctg gta gga gga att gtt ggt aca ctt cat caa aga tct acc       2283
Gln Pro Leu Val Gly Gly Ile Val Gly Thr Leu His Gln Arg Ser Thr           
        625                 630                 635                       

ttt aaa cca gaa gaa gga aaa gaa gca ggc tat gca gac cta gat cct       2331
Phe Lys Pro Glu Glu Gly Lys Glu Ala Gly Tyr Ala Asp Leu Asp Pro           
    640                 645                 650                           

tac aac tca cca ggg cag gaa gtt tat cat gcc tat gct gaa cca ctc       2379
Tyr Asn Ser Pro Gly Gln Glu Val Tyr His Ala Tyr Ala Glu Pro Leu           
655                 660                 665                 670           

cca att acg ggg cct gag tat gca acc cca atc atc atg gac atg tca       2427
Pro Ile Thr Gly Pro Glu Tyr Ala Thr Pro Ile Ile Met Asp Met Ser           
                675                 680                 685               

ggg cac ccc aca act tca gtt ggt cag ccc tcc aca tcc act ttc aag       2475
Gly His Pro Thr Thr Ser Val Gly Gln Pro Ser Thr Ser Thr Phe Lys           
            690                 695                 700                   

gct acg ggg aac caa cct ccc cca cta gtg gga act tac aat aca ctt       2523
Ala Thr Gly Asn Gln Pro Pro Pro Leu Val Gly Thr Tyr Asn Thr Leu           
        705                 710                 715                       

ctc tcc agg act gac agc tgc tcc tca gcc cag gcc cag tat gat acc       2571
Leu Ser Arg Thr Asp Ser Cys Ser Ser Ala Gln Ala Gln Tyr Asp Thr           
    720                 725                 730                           

ccg aaa gct ggg aag cca ggt cta cct gcc cca gac gaa ttg gtg tac       2619
Pro Lys Ala Gly Lys Pro Gly Leu Pro Ala Pro Asp Glu Leu Val Tyr           
735                 740                 745                 750           

cag gtg cca cag agc aca caa gaa gta tca gga gca gga agg gat ggg       2667
Gln Val Pro Gln Ser Thr Gln Glu Val Ser Gly Ala Gly Arg Asp Gly           
                755                 760                 765               

gaa tgt gat gtt ttt aaa gaa atc ctt tga agatgatgct gctttttaca         2717
Glu Cys Asp Val Phe Lys Glu Ile Leu                                       
            770                 775                                       

aagcatcgtt ttaaagcaca tggccttttt tttttaatta ttagtggtag taatatatag     2777

aatgtattac ataactgtca ctgaagtggt tggggaaaat gtggtgactg aggtacagga     2837

aactactaat cttgccatct tgctttaagg tgttatggtg gcacagttac tgctcgcctg     2897

ttaaatttca aatgtcctgt ttgatactac tgtagaacac tatttttaat acagaaaaag     2957

ctccctataa tgcacttcag agaaattaaa aatcacagag tatttattac caatgctgca     3017

ggtacattaa tgaactcgag atggctctgt aagcctgact ggcaataacg cacggtactg     3077

ttcttgaaat acctaatggc ttgaaattct agtctgtttg tgaaagatgg gtactatcat     3137

gatttcctct tctattccta tattcttttc tggatttttt ttaataatta gtgatataag     3197

cattgttttt attgcagcca tatccactta tccatcttaa gatctgtagc tgggattttc     3257

tgacttgtaa tgagcagggg gattgctttt tcactttgtg acactcttta gagctttaat     3317

gcttcacagt atatggcctg gtctcatcct tgcgtgttcc acttgaggcc ctttggtgtc     3377

ttgccccatt cttgtgttta taaaatgttt gagtatttct gatgagtgat gcttgcctta     3437

gtctcatgaa ttcagatccc ttcatgtcct ttaagtatgc tcctcaatgt gtaaacagga     3497

acaactttat gatttgaaag ctttaaagga gattcttctc ccacccccaa ctttatttgc     3557

aatgggattt ttcctaggag agttatgaaa agttgaaggc ttctaaggga atactgtaaa     3617

catgacccac ttatatttat cacagtgaaa ggcaaaatta ttcactcaga agtaatataa     3677

attacctctt taaaaagtaa ccagaatttg tcctttttgg ttttatacat tcacaaacat     3737

atacattttt cttgagtctc aaggtatttt atatttttag tcagaaaaaa taatttttca     3797

tttcagtttt ccataaactg ttacacaaaa tataaaccta acgtgtattt ttcaggactg     3857

cgtgatcgtg cactttgtgt ggtaagaggt ttgagtagtc ctatatgtca cctagggaac     3917

agacattata gcttactagc aaatgaatat tcatgccttg tttttgatac ctcctggcag     3977

cttccatgtc accacttgtt catacctgcc cagagctagt tttagacatg gcaaaataga     4037

aatcatctgt aatttattag ctaacaatgt aaaaccatct tttaaagcct tcagactgtc     4097

aagacgacat gagcagctca ccatatgata aaaatacata aatttgacat tccctcttcc     4157

ataaaccttt gtttgtagat ttaatgttga acagtacttt tccataaagt tctagtcact     4217

tctgttggcc tgagccacca gattatgatg ttgccagaat tcactcaatt tgaataaaga     4277

tgaacagtat ttgttttctt gtttccatga attatatcag tattctaaaa catcgcttca     4337

gaaagagaac tgtttatttc tgcaggcttc ctgtcctttt gtggtatggt tttttggcct     4397

tattttcact ggcttttcct tctccaaact ttgaggcgtg atttcattca ttgaagaatc     4457

aatacatatt ttgtttcaaa atgtttgaaa caaaagacat agatggtaga cttttattaa     4517

aacatatatg gatgtggaaa gcacatatat taatgcagtc atcccttttc aggtgggaag     4577

agagcaaacc agttgatttt ttaattcatc cttagtacac agagaatata cttttcctca     4637

agtaatatac ctgtttgaag ctttaagaga gatgtttttg gtaactattt cattttccca     4697

aagaagtttg ctattcttgt gttaattgtg tatacctgat tgttttttcc tggaggtttt     4757

tgttgttgtt gtttagtttt gggttttttt ttttttaaga ggggcaagtg ttttctgaaa     4817

tgatgcatat tttaagactc gattcatatt gccactgtgc tatccttgaa ctaccaataa     4877

tttttataaa atatctagtt tttactactt ttatataaac tttactttcc agatgaagag     4937

ctgagcctga ttcaaatggt ttttctgctt tatacttctt tttagttcat tggtttttat     4997

agtagaggtt ttctattttt tttttttttt tttttactac atttatatgt ctgatacata     5057

tacggctttg gagacaatca agtaacaact gaaaatgtga aagtaaccat atctgacaaa     5117

attcccttga atttttatcc tttgcttgca acatttaaga ctcaaagtca ctggtatatt     5177

ggattaagtt ttttcctgtt aatgcaatta tagaaataca tcggagacac aacaaatgtg     5237

gccattacag gtttcataaa attacactga cttggctgtt acttgatctt aggaaacagc     5297

acagtttaag atattgtgaa ttctgactta tactttatta aatgctgtaa atctaaatag     5357

atcctgttgg atgtgatggg tctagtccag tttatttaag ttcatgtttc actgtttgca     5417

ctttgcattg aacaatgggt ttattcgctg atgtaaacgg ttcgagtgaa gaattaatgc     5477

agtaagtatg acaacacata cacacttgcc tctccccatc tccagaagag gggagcagag     5537

tccgagctta tctaaatatg aatgtggcca caaagctgtg gaaggtgaca aagcttaaac     5597

acctttgccc tggctctgca ttgtcaccta gagagcaaga ggtctataga aacatcatgt     5657

cacatgaaac gattctctgc tttttggttc tgaacttgaa gtccctaaac tgcaaaatct     5717

aagagttggg tggttattaa aatgctttta aagtcaactg tggcaccaat tctaatgtaa     5777

tccaacttgt gactgttttt ttttgttttg ttttgttttt gtgtgtgtgt gtgtggcact     5837

gggaaaagtg gaaacaaaca tgtattgaaa tacatattgg aaataaaaat ggtttgagcg     5897

tcagtgatat tctcccagaa tgtacttatc ttacctcggc atgtactgta gtcactcagt     5957

atttgtatat gttgctagaa tttagattgt aaaatagtga aattttaatg tgttcatttg     6017

tttttaatgt atatatgtct tgctcagatt atttggttta aataaaacaa ccttgaggtt     6077

tgtagctttt ccttatacta taaaatgcca gattcttcta ttttaacctc a              6128


<210>  16
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ser Arg Ala Val Val Arg Ala Arg Arg Cys Pro Gln Cys Pro 
1               5                   10                  15      


Gln Val Arg Ala Ala Ala Ala Ala Pro Ala Trp Ala Ala Leu Pro Leu 
            20                  25                  30          


Ser Arg Ser Leu Pro Pro Cys Ser Asn Ser Ser Ser Phe Ser Met Pro 
        35                  40                  45              


Leu Phe Leu Leu Leu Leu Leu Val Leu Leu Leu Leu Leu Glu Asp Ala 
    50                  55                  60                  


Gly Ala Gln Gln Gly Asp Gly Cys Gly His Thr Val Leu Gly Pro Glu 
65                  70                  75                  80  


Ser Gly Thr Leu Thr Ser Ile Asn Tyr Pro Gln Thr Tyr Pro Asn Ser 
                85                  90                  95      


Thr Val Cys Glu Trp Glu Ile Arg Val Lys Met Gly Glu Arg Val Arg 
            100                 105                 110         


Ile Lys Phe Gly Asp Phe Asp Ile Glu Asp Ser Asp Ser Cys His Phe 
        115                 120                 125             


Asn Tyr Leu Arg Ile Tyr Asn Gly Ile Gly Val Ser Arg Thr Glu Ile 
    130                 135                 140                 


Gly Lys Tyr Cys Gly Leu Gly Leu Gln Met Asn His Ser Ile Glu Ser 
145                 150                 155                 160 


Lys Gly Asn Glu Ile Thr Leu Leu Phe Met Ser Gly Ile His Val Ser 
                165                 170                 175     


Gly Arg Gly Phe Leu Ala Ser Tyr Ser Val Ile Asp Lys Gln Asp Leu 
            180                 185                 190         


Ile Thr Cys Leu Asp Thr Ala Ser Asn Phe Leu Glu Pro Glu Phe Ser 
        195                 200                 205             


Lys Tyr Cys Pro Ala Gly Cys Leu Leu Pro Phe Ala Glu Ile Ser Gly 
    210                 215                 220                 


Thr Ile Pro His Gly Tyr Arg Asp Ser Ser Pro Leu Cys Met Ala Gly 
225                 230                 235                 240 


Val His Ala Gly Val Val Ser Asn Thr Leu Gly Gly Gln Ile Ser Val 
                245                 250                 255     


Val Ile Ser Lys Gly Ile Pro Tyr Tyr Glu Ser Ser Leu Ala Asn Asn 
            260                 265                 270         


Val Thr Ser Val Val Gly His Leu Ser Thr Ser Leu Phe Thr Phe Lys 
        275                 280                 285             


Thr Ser Gly Cys Tyr Gly Thr Leu Gly Met Glu Ser Gly Val Ile Ala 
    290                 295                 300                 


Asp Pro Gln Ile Thr Ala Ser Ser Val Leu Glu Trp Thr Asp His Thr 
305                 310                 315                 320 


Gly Gln Glu Asn Ser Trp Lys Pro Lys Lys Ala Arg Leu Lys Lys Pro 
                325                 330                 335     


Gly Pro Pro Trp Ala Ala Phe Ala Thr Asp Glu Tyr Gln Trp Leu Gln 
            340                 345                 350         


Ile Asp Leu Asn Lys Glu Lys Lys Ile Thr Gly Ile Ile Thr Thr Gly 
        355                 360                 365             


Ser Thr Met Val Glu His Asn Tyr Tyr Val Ser Ala Tyr Arg Ile Leu 
    370                 375                 380                 


Tyr Ser Asp Asp Gly Gln Lys Trp Thr Val Tyr Arg Glu Pro Gly Val 
385                 390                 395                 400 


Glu Gln Asp Lys Ile Phe Gln Gly Asn Lys Asp Tyr His Gln Asp Val 
                405                 410                 415     


Arg Asn Asn Phe Leu Pro Pro Ile Ile Ala Arg Phe Ile Arg Val Asn 
            420                 425                 430         


Pro Thr Gln Trp Gln Gln Lys Ile Ala Met Lys Met Glu Leu Leu Gly 
        435                 440                 445             


Cys Gln Phe Ile Pro Lys Gly Arg Pro Pro Lys Leu Thr Gln Pro Pro 
    450                 455                 460                 


Pro Pro Arg Asn Ser Asn Asp Leu Lys Asn Thr Thr Ala Pro Pro Lys 
465                 470                 475                 480 


Ile Ala Lys Gly Arg Ala Pro Lys Phe Thr Gln Pro Leu Gln Pro Arg 
                485                 490                 495     


Ser Ser Asn Glu Phe Pro Ala Gln Thr Glu Gln Thr Thr Ala Ser Pro 
            500                 505                 510         


Asp Ile Arg Asn Thr Thr Val Thr Pro Asn Val Thr Lys Asp Val Ala 
        515                 520                 525             


Leu Ala Ala Val Leu Val Pro Val Leu Val Met Val Leu Thr Thr Leu 
    530                 535                 540                 


Ile Leu Ile Leu Val Cys Ala Trp His Trp Arg Asn Arg Lys Lys Lys 
545                 550                 555                 560 


Thr Glu Gly Thr Tyr Asp Leu Pro Tyr Trp Asp Arg Ala Gly Trp Trp 
                565                 570                 575     


Lys Gly Met Lys Gln Phe Leu Pro Ala Lys Ala Val Asp His Glu Glu 
            580                 585                 590         


Thr Pro Val Arg Tyr Ser Ser Ser Glu Val Asn His Leu Ser Pro Arg 
        595                 600                 605             


Glu Val Thr Thr Val Leu Gln Ala Asp Ser Ala Glu Tyr Ala Gln Pro 
    610                 615                 620                 


Leu Val Gly Gly Ile Val Gly Thr Leu His Gln Arg Ser Thr Phe Lys 
625                 630                 635                 640 


Pro Glu Glu Gly Lys Glu Ala Gly Tyr Ala Asp Leu Asp Pro Tyr Asn 
                645                 650                 655     


Ser Pro Gly Gln Glu Val Tyr His Ala Tyr Ala Glu Pro Leu Pro Ile 
            660                 665                 670         


Thr Gly Pro Glu Tyr Ala Thr Pro Ile Ile Met Asp Met Ser Gly His 
        675                 680                 685             


Pro Thr Thr Ser Val Gly Gln Pro Ser Thr Ser Thr Phe Lys Ala Thr 
    690                 695                 700                 


Gly Asn Gln Pro Pro Pro Leu Val Gly Thr Tyr Asn Thr Leu Leu Ser 
705                 710                 715                 720 


Arg Thr Asp Ser Cys Ser Ser Ala Gln Ala Gln Tyr Asp Thr Pro Lys 
                725                 730                 735     


Ala Gly Lys Pro Gly Leu Pro Ala Pro Asp Glu Leu Val Tyr Gln Val 
            740                 745                 750         


Pro Gln Ser Thr Gln Glu Val Ser Gly Ala Gly Arg Asp Gly Glu Cys 
        755                 760                 765             


Asp Val Phe Lys Glu Ile Leu 
    770                 775 


<210>  17
<211>  1949
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (87)..(1529)

<400>  17
aactgtcact gtggagagga gagagagagg acagagagca agtcactccc ggctgccttt       60

ttcacctctg acagagccca gacacc atg aac gca agt gaa ttc cga agg aga       113
                             Met Asn Ala Ser Glu Phe Arg Arg Arg          
                             1               5                            

ggg aag gag atg gtg gat tac atg gcc aac tac atg gaa ggc att gag        161
Gly Lys Glu Met Val Asp Tyr Met Ala Asn Tyr Met Glu Gly Ile Glu           
10                  15                  20                  25            

gga cgc cag gtc tac cct gac gtg gag ccc ggg tac ctg cgg ccg ctg        209
Gly Arg Gln Val Tyr Pro Asp Val Glu Pro Gly Tyr Leu Arg Pro Leu           
                30                  35                  40                

atc cct gcc gct gcc cct cag gag cca gac acg ttt gag gac atc atc        257
Ile Pro Ala Ala Ala Pro Gln Glu Pro Asp Thr Phe Glu Asp Ile Ile           
            45                  50                  55                    

aac gac gtt gag aag ata atc atg cct ggg gtg acg cac tgg cac agc        305
Asn Asp Val Glu Lys Ile Ile Met Pro Gly Val Thr His Trp His Ser           
        60                  65                  70                        

ccc tac ttc ttc gcc tac ttc ccc act gcc agc tcg tac ccg gcc atg        353
Pro Tyr Phe Phe Ala Tyr Phe Pro Thr Ala Ser Ser Tyr Pro Ala Met           
    75                  80                  85                            

ctt gcg gac atg ctg tgc ggg gcc att ggc tgc atc ggc ttc tcc tgg        401
Leu Ala Asp Met Leu Cys Gly Ala Ile Gly Cys Ile Gly Phe Ser Trp           
90                  95                  100                 105           

gcg gca agc cca gca tgc aca gag ctg gag act gtg atg atg gac tgg        449
Ala Ala Ser Pro Ala Cys Thr Glu Leu Glu Thr Val Met Met Asp Trp           
                110                 115                 120               

ctc ggg aag atg ctg gaa cta cca aag gca ttt ttg aat gag aaa gct        497
Leu Gly Lys Met Leu Glu Leu Pro Lys Ala Phe Leu Asn Glu Lys Ala           
            125                 130                 135                   

gga gaa ggg gga gga gtg atc cag gga agt gcc agt gaa gcc acc ctg        545
Gly Glu Gly Gly Gly Val Ile Gln Gly Ser Ala Ser Glu Ala Thr Leu           
        140                 145                 150                       

gtg gcc ctg ctg gcc gct cgg acc aaa gtg atc cat cgg ctg cag gca        593
Val Ala Leu Leu Ala Ala Arg Thr Lys Val Ile His Arg Leu Gln Ala           
    155                 160                 165                           

gcg tcc cca gag ctc aca cag gcc gct atc atg gag aag ctg gtg gct        641
Ala Ser Pro Glu Leu Thr Gln Ala Ala Ile Met Glu Lys Leu Val Ala           
170                 175                 180                 185           

tac tca tcc gat cag gca cac tcc tca gtg gaa aga gct ggg tta att        689
Tyr Ser Ser Asp Gln Ala His Ser Ser Val Glu Arg Ala Gly Leu Ile           
                190                 195                 200               

ggt gga gtg aaa tta aaa gcc atc ccc tca gat ggc aac ttc gcc atg        737
Gly Gly Val Lys Leu Lys Ala Ile Pro Ser Asp Gly Asn Phe Ala Met           
            205                 210                 215                   

cgt gcg tct gcc ctg cag gaa gcc ctg gag aga gac aaa gcg gct ggc        785
Arg Ala Ser Ala Leu Gln Glu Ala Leu Glu Arg Asp Lys Ala Ala Gly           
        220                 225                 230                       

ctg att cct ttc ttt atg gtt gcc acc ctg ggg acc aca aca tgc tgc        833
Leu Ile Pro Phe Phe Met Val Ala Thr Leu Gly Thr Thr Thr Cys Cys           
    235                 240                 245                           

tcc ttt gac aat ctc tta gaa gtc ggt cct atc tgc aac aag gaa gac        881
Ser Phe Asp Asn Leu Leu Glu Val Gly Pro Ile Cys Asn Lys Glu Asp           
250                 255                 260                 265           

ata tgg ctg cac gtt gat gca gcc tac gca ggc agt gca ttc atc tgc        929
Ile Trp Leu His Val Asp Ala Ala Tyr Ala Gly Ser Ala Phe Ile Cys           
                270                 275                 280               

cct gag ttc cgg cac ctt ctg aat gga gtg gag ttt gca gat tca ttc        977
Pro Glu Phe Arg His Leu Leu Asn Gly Val Glu Phe Ala Asp Ser Phe           
            285                 290                 295                   

aac ttt aat ccc cac aaa tgg cta ttg gtg aat ttt gac tgt tct gcc       1025
Asn Phe Asn Pro His Lys Trp Leu Leu Val Asn Phe Asp Cys Ser Ala           
        300                 305                 310                       

atg tgg gtg aaa aag aga aca gac tta acg gga gcc ttt aga ctg gac       1073
Met Trp Val Lys Lys Arg Thr Asp Leu Thr Gly Ala Phe Arg Leu Asp           
    315                 320                 325                           

ccc act tac ctg aag cac agc cat cag gat tca ggg ctt atc act gac       1121
Pro Thr Tyr Leu Lys His Ser His Gln Asp Ser Gly Leu Ile Thr Asp           
330                 335                 340                 345           

tac cgg cat tgg cag ata cca ctg ggc aga aga ttt cgc tct ttg aaa       1169
Tyr Arg His Trp Gln Ile Pro Leu Gly Arg Arg Phe Arg Ser Leu Lys           
                350                 355                 360               

atg tgg ttt gta ttt agg atg tat gga gtc aaa gga ctg cag gct tat       1217
Met Trp Phe Val Phe Arg Met Tyr Gly Val Lys Gly Leu Gln Ala Tyr           
            365                 370                 375                   

atc cgc aag cat gtc cag ctg tcc cat gag ttt gag tca ctg gtg cgc       1265
Ile Arg Lys His Val Gln Leu Ser His Glu Phe Glu Ser Leu Val Arg           
        380                 385                 390                       

cag gat ccc cgc ttt gaa atc tgt gtg gaa gtc att ctg ggg ctt gtc       1313
Gln Asp Pro Arg Phe Glu Ile Cys Val Glu Val Ile Leu Gly Leu Val           
    395                 400                 405                           

tgc ttt cgg cta aag ggt tcc aac aaa gtg aat gaa gct ctt ctg caa       1361
Cys Phe Arg Leu Lys Gly Ser Asn Lys Val Asn Glu Ala Leu Leu Gln           
410                 415                 420                 425           

aga ata aac agt gcc aaa aaa atc cac ttg gtt cca tgt cac ctc agg       1409
Arg Ile Asn Ser Ala Lys Lys Ile His Leu Val Pro Cys His Leu Arg           
                430                 435                 440               

gac aag ttt gtc ctg cgc ttt gcc atc tgt tct cgc acg gtg gaa tct       1457
Asp Lys Phe Val Leu Arg Phe Ala Ile Cys Ser Arg Thr Val Glu Ser           
            445                 450                 455                   

gcc cat gtg cag cgg gcc tgg gaa cac atc aaa gag ctg gcg gcc gac       1505
Ala His Val Gln Arg Ala Trp Glu His Ile Lys Glu Leu Ala Ala Asp           
        460                 465                 470                       

gtg ctg cga gca gag agg gag tag gagtgaagcc agctgcagga atcaaaaatt      1559
Val Leu Arg Ala Glu Arg Glu                                               
    475                 480                                               

gaagagagat atatctgaaa actggaataa gaagcaaata aatatcatcc tgccttcatg     1619

gaactcagct gtctgtggct tcccatgtct ttctccaaag ttatccagag ggttgtgatt     1679

ttgtctgctt agtatctcat caacaaagaa atattatttg ctaattaaaa agttaatctt     1739

catggccata gcttttattc attagctgtg atttttgttg attaaaacat tatagatttt     1799

catgttcttg cagtcatcag aagtggtagg aaagcctcac tgatatattt tccagggcaa     1859

tcaatgttca cgcaacttga aattatatct gtggtcttca aattgtcttt tgtcatgtgg     1919

ctaaatgcct aataaacaat tcaagtgaaa                                      1949


<210>  18
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Met Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  19
<211>  3624
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(1919)

<400>  19
ggactcgcgc tcgcccgctg gcgccctcgg cttctctccg cgcctgggag caccctccgc       60

cgcggccgtt ctccatgcgc agcgcccgcc cgaggagcta gacgtcagct tggagcggcg      120

ccggaccgtg g atg gcc ttg act gac ggc ggc tgg tgc ttg ccg aag cgc       170
             Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg          
             1               5                   10                       

ttc ggg gcc gcg ggt gcg gac gcc agc gac tcc aga gcc ttt cca gcg        218
Phe Gly Ala Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala           
    15                  20                  25                            

cgg gag ccc tcc acg ccg cct tcc ccc atc tct tcc tcg tcc tcc tcc        266
Arg Glu Pro Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser           
30                  35                  40                  45            

tgc tcc cgg ggc gga gag cgg ggc ccc ggc ggc gcc agc aac tgc ggg        314
Cys Ser Arg Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly           
                50                  55                  60                

acg cct cag ctc gac acg gag gcg gcg gcc gga ccc ccg gcc cgc tcg        362
Thr Pro Gln Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser           
            65                  70                  75                    

ctg ctg ctc agt tcc tac gct tcg cat ccc ttc ggg gct ccc cac gga        410
Leu Leu Leu Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly           
        80                  85                  90                        

cct tcg gcg cct ggg gtc gcg ggc ccc ggg ggc aac ctg tcg agc tgg        458
Pro Ser Ala Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp           
    95                  100                 105                           

gag gac ttg ctg ctg ttc act gac ctc gac caa gcc gcg acc gcc agc        506
Glu Asp Leu Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser           
110                 115                 120                 125           

aag ctg ctg tgg tcc agc cgc ggc gcc aag ctg agc ccc ttc gca ccc        554
Lys Leu Leu Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro           
                130                 135                 140               

gag cag ccg gag gag atg tac cag acc ctc gcc gct ctc tcc agc cag        602
Glu Gln Pro Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln           
            145                 150                 155                   

ggt ccg gcc gcc tac gac ggc gcg ccc ggc ggc ttc gtg cac tct gcg        650
Gly Pro Ala Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala           
        160                 165                 170                       

gcc gcg gcg gca gca gcc gcg gcg gcg gcc agc tcc ccg gtc tac gtg        698
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val           
    175                 180                 185                           

ccc acc acc cgc gtg ggt tcc atg ctg ccc ggc cta ccg tac cac ctg        746
Pro Thr Thr Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu           
190                 195                 200                 205           

cag ggg tcg ggc agt ggg cca gcc aac cac gcg ggc ggc gcg ggc gcg        794
Gln Gly Ser Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala           
                210                 215                 220               

cac ccc ggc tgg cct cag gcc tcg gcc gac agc cct cca tac ggc agc        842
His Pro Gly Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser           
            225                 230                 235                   

gga ggc ggc gcg gct ggc ggc ggg gcc gcg ggg cct ggc ggc gct ggc        890
Gly Gly Gly Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly           
        240                 245                 250                       

tca gcc gcg gcg cac gtc tcg gcg cgc ttc ccc tac tct ccc agc ccg        938
Ser Ala Ala Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro           
    255                 260                 265                           

ccc atg gcc aac ggc gcc gcg cgg gag ccg gga ggc tac gcg gcg gcg        986
Pro Met Ala Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala           
270                 275                 280                 285           

ggc agt ggg ggc gcg gga ggc gtg agc ggc ggc ggc agt agc ctg gcg       1034
Gly Ser Gly Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala           
                290                 295                 300               

gcc atg ggc ggc cgc gag ccc cag tac agc tcg ctg tcg gcc gcg cgg       1082
Ala Met Gly Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg           
            305                 310                 315                   

ccg ctg aac ggg acg tac cac cac cac cac cac cac cac cac cac cat       1130
Pro Leu Asn Gly Thr Tyr His His His His His His His His His His           
        320                 325                 330                       

ccg agc ccc tac tcg ccc tac gtg ggg gcg cca ctg acg cct gcc tgg       1178
Pro Ser Pro Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp           
    335                 340                 345                           

ccc gcc gga ccc ttc gag acc ccg gtg ctg cac agc ctg cag agc cgc       1226
Pro Ala Gly Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg           
350                 355                 360                 365           

gcc gga gcc ccg ctc ccg gtg ccc cgg ggt ccc agt gca gac ctg ctg       1274
Ala Gly Ala Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu           
                370                 375                 380               

gag gac ctg tcc gag agc cgc gag tgc gtg aac tgc ggc tcc atc cag       1322
Glu Asp Leu Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln           
            385                 390                 395                   

acg ccg ctg tgg cgg cgg gac ggc acc ggc cac tac ctg tgc aac gcc       1370
Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala           
        400                 405                 410                       

tgc ggg ctc tac agc aag atg aac ggc ctc agc cgg ccc ctc atc aag       1418
Cys Gly Leu Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys           
    415                 420                 425                           

ccg cag aag cgc gtg cct tca tca cgg cgg ctt gga ttg tcc tgt gcc       1466
Pro Gln Lys Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala           
430                 435                 440                 445           

aac tgt cac acc aca act acc acc tta tgg cgc aga aac gcc gag ggt       1514
Asn Cys His Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly           
                450                 455                 460               

gaa ccc gtg tgc aat gct tgt gga ctc tac atg aaa ctc cat ggg gtg       1562
Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val           
            465                 470                 475                   

ccc aga cca ctt gct atg aaa aaa gag gga att caa acc agg aaa cga       1610
Pro Arg Pro Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg           
        480                 485                 490                       

aaa cct aag aac ata aat aaa tca aag act tgc tct ggt aat agc aat       1658
Lys Pro Lys Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn           
    495                 500                 505                           

aat tcc att ccc atg act cca act tcc acc tct tct aac tca gat gat       1706
Asn Ser Ile Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp           
510                 515                 520                 525           

tgc agc aaa aat act tcc ccc aca aca caa cct aca gcc tca ggg gcg       1754
Cys Ser Lys Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala           
                530                 535                 540               

ggt gcc ccg gtg atg act ggt gcg gga gag agc acc aat ccc gag aac       1802
Gly Ala Pro Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn           
            545                 550                 555                   

agc gag ctc aag tat tcg ggt caa gat ggg ctc tac ata ggc gtc agt       1850
Ser Glu Leu Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser           
        560                 565                 570                       

ctc gcc tcg ccg gcc gaa gtc acg tcc tcc gtg cga ccg gat tcc tgg       1898
Leu Ala Ser Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp           
    575                 580                 585                           

tgc gcc ctg gcc ctg gcc tga gcccacgccg ccaggaggca gggagggctc          1949
Cys Ala Leu Ala Leu Ala                                                   
590                 595                                                   

cgccgcgggc ctcactccac tcgtgtctgc ttttgtgcag cggtccagac agtggcgact     2009

gcgctgacag aacgtgattc tcgtgccttt attttgaaag agatgttttt cccaagaggc     2069

ttgctgaaag agtgagagaa gatggaaggg aagggccagt gcaactgggc gcttgggcca     2129

ctccagccag cccgcctccg gggcggaccc tgctccactt ccagaagcca ggactaggac     2189

ctgggccttg cctgctatgg aatattgaga gagatttttt aaaaaagatt ttgcattttg     2249

tccaaaatca tgtgcttctt ctgatcaatt ttggttgttc cagaatttct tcataccttt     2309

tccacatcca gatttcatgt gcgttcatgg agaagatcac ttgaggccat ttggtacaca     2369

tctctggagg ctgagtcggt tcatgaggtc tcttatcaaa aatattactc agtttgcaag     2429

actgcattgt aactttaaca tacactgtga ctgacgtttc tcaaagttca tattgtgtgg     2489

ctgatctgaa gtcagtcgga atttgtaaac agggtagcaa acaagatatt tttcttccat     2549

gtatacaata atttttttaa aaagtgcaat ttgcgttgca gcaatcagtg ttaaatcatt     2609

tgcataagat ttaacagcat tttttataat gaatgtaaac attttaactt aatggtactt     2669

aaaataattt aaaagaaaaa tgttaactta gacattctta tgcttctttt acaactacat     2729

cccattttat atttccaatt gttaaagaaa aatatttcaa gaacaaatct tctctcagga     2789

aaattgcctt tctctatttg ttaagaattt ttatacaaga acaccaatat acccccttta     2849

ttttactgtg gaatatgtgc tggaaaaatt gcaacaacac tttactacct aacggatagc     2909

atttgtaaat actctaggta tctgtaaaca ctctgatgaa gtctgtatag tgtgactaac     2969

ccacaggcag gttggtttac attaattttt ttttttgaat gggatgtcct atggaaacct     3029

atttcaccag agttttaaaa ataaaaaggg tattgttttg tcttctgtac agtgagttcc     3089

ttcccttttc aaagctttct ttttatgctg tatgtgacta tagatattca tataaaacaa     3149

gtgcacgtga agtttgcaaa atgctttaag gccttccttt caaagcatag tccttttgga     3209

gccgttttgt accttttata ccttggctta tttgaagttg acacatgggg ttagttacta     3269

ctctccatgt gcattgggga cagtttttat aagtgggaag gactcagtat tattatattt     3329

gagatgataa gcattttgtt tgggaacaat gcttaaaaat attccagaaa gttcagattt     3389

tttttctttg tgaatgaaat atattctggc ccacgaacag ggcgatttcc tttcagtttt     3449

ttccttttgc aacgtgcctt gaagtctcaa agctcacctg aggttgcaga cgttaccccc     3509

aacagaagat aggtagaaat gattccagtg gcctctttgt attttcttca ttgttgagta     3569

gatttcagga aatcaggagg tgtttcacaa tacagaatga tggcctttaa ctgtg          3624


<210>  20
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      


Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          


Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              


Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  


Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  


Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      


Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         


Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             


Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 


Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 


Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         


Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             


Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 


Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     


Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         


Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             


Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 


Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 


Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     


Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         


Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             


Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 


Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     


Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         


Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 


Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     


Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         


Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             


Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 


Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 


Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     


Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         


Ala Leu Ala 
        595 


<210>  21
<211>  1493
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (334)..(1410)

<400>  21
agtagtcgcc tggcaggaga atttgaaagg gtgccccaaa ggacaatctc taaaggggta       60

agggagatac ctaccttgtc tggtagggga gatgtttcgt tttcatgctt taccagaaaa      120

tccacttccc tgccgacctt agtttcaaag cttattctta attagagaca agaaacctgt      180

ttcaacttga agacaccgta tgaggtgaat ggacagccag ccaccacaat gaaagaaatc      240

aaaccaggaa taacctatgc tgaacccacg cctcaatcgt ccccaagtgt ttcctgacac      300

gcatctttgc ttacagtgca tcacaactga aga atg ggg ttc aac ttg acg ctt       354
                                     Met Gly Phe Asn Leu Thr Leu          
                                     1               5                    

gca aaa tta cca aat aac gag ctg cac ggc caa gag agt cac aat tca        402
Ala Lys Leu Pro Asn Asn Glu Leu His Gly Gln Glu Ser His Asn Ser           
        10                  15                  20                        

ggc aac agg agc gac ggg cca gga aag aac acc acc ctt cac aat gaa        450
Gly Asn Arg Ser Asp Gly Pro Gly Lys Asn Thr Thr Leu His Asn Glu           
    25                  30                  35                            

ttt gac aca att gtc ttg ccg gtg ctt tat ctc att ata ttt gtg gca        498
Phe Asp Thr Ile Val Leu Pro Val Leu Tyr Leu Ile Ile Phe Val Ala           
40                  45                  50                  55            

agc atc ttg ctg aat ggt tta gca gtg tgg atc ttc ttc cac att agg        546
Ser Ile Leu Leu Asn Gly Leu Ala Val Trp Ile Phe Phe His Ile Arg           
                60                  65                  70                

aat aaa acc agc ttc ata ttc tat ctc aaa aac ata gtg gtt gca gac        594
Asn Lys Thr Ser Phe Ile Phe Tyr Leu Lys Asn Ile Val Val Ala Asp           
            75                  80                  85                    

ctc ata atg acg ctg aca ttt cca ttt cga ata gtc cat gat gca gga        642
Leu Ile Met Thr Leu Thr Phe Pro Phe Arg Ile Val His Asp Ala Gly           
        90                  95                  100                       

ttt gga cct tgg tac ttc aag ttt att ctc tgc aga tac act tca gtt        690
Phe Gly Pro Trp Tyr Phe Lys Phe Ile Leu Cys Arg Tyr Thr Ser Val           
    105                 110                 115                           

ttg ttt tat gca aac atg tat act tcc atc gtg ttc ctt ggg ctg ata        738
Leu Phe Tyr Ala Asn Met Tyr Thr Ser Ile Val Phe Leu Gly Leu Ile           
120                 125                 130                 135           

agc att gat cgc tat ctg aag gtg gtc aag cca ttt ggg gac tct cgg        786
Ser Ile Asp Arg Tyr Leu Lys Val Val Lys Pro Phe Gly Asp Ser Arg           
                140                 145                 150               

atg tac agc ata acc ttc acg aag gtt tta tct gtt tgt gtt tgg gtg        834
Met Tyr Ser Ile Thr Phe Thr Lys Val Leu Ser Val Cys Val Trp Val           
            155                 160                 165                   

atc atg gct gtt ttg tct ttg cca aac atc atc cta aca aat ggt cag        882
Ile Met Ala Val Leu Ser Leu Pro Asn Ile Ile Leu Thr Asn Gly Gln           
        170                 175                 180                       

cca aca gag gac aat atc cat gac tgc tca aaa ctt aaa agt cct ttg        930
Pro Thr Glu Asp Asn Ile His Asp Cys Ser Lys Leu Lys Ser Pro Leu           
    185                 190                 195                           

ggg gtc aaa tgg cat acg gca gtc acc tat gtg aac agc tgc ttg ttt        978
Gly Val Lys Trp His Thr Ala Val Thr Tyr Val Asn Ser Cys Leu Phe           
200                 205                 210                 215           

gtg gcc gtg ctg gtg att ctg atc gga tgt tac ata gcc ata tcc agg       1026
Val Ala Val Leu Val Ile Leu Ile Gly Cys Tyr Ile Ala Ile Ser Arg           
                220                 225                 230               

tac atc cac aaa tcc agc agg caa ttc ata agt cag tca agc cga aag       1074
Tyr Ile His Lys Ser Ser Arg Gln Phe Ile Ser Gln Ser Ser Arg Lys           
            235                 240                 245                   

cga aaa cat aac cag agc atc agg gtt gtt gtg gct gtg ttt ttt acc       1122
Arg Lys His Asn Gln Ser Ile Arg Val Val Val Ala Val Phe Phe Thr           
        250                 255                 260                       

tgc ttt cta cca tat cac ttg tgc aga att cct ttt act ttt agt cac       1170
Cys Phe Leu Pro Tyr His Leu Cys Arg Ile Pro Phe Thr Phe Ser His           
    265                 270                 275                           

tta gac agg ctt tta gat gaa tct gca caa aaa atc cta tat tac tgc       1218
Leu Asp Arg Leu Leu Asp Glu Ser Ala Gln Lys Ile Leu Tyr Tyr Cys           
280                 285                 290                 295           

aaa gaa att aca ctt ttc ttg tct gcg tgt aat gtt tgc ctg gat cca       1266
Lys Glu Ile Thr Leu Phe Leu Ser Ala Cys Asn Val Cys Leu Asp Pro           
                300                 305                 310               

ata att tac ttt ttc atg tgt agg tca ttt tca aga agg ctg ttc aaa       1314
Ile Ile Tyr Phe Phe Met Cys Arg Ser Phe Ser Arg Arg Leu Phe Lys           
            315                 320                 325                   

aaa tca aat atc aga acc agg agt gaa agc atc aga tca ctg caa agt       1362
Lys Ser Asn Ile Arg Thr Arg Ser Glu Ser Ile Arg Ser Leu Gln Ser           
        330                 335                 340                       

gtg aga aga tcg gaa gtt cgc ata tat tat gat tac act gat gtg tag       1410
Val Arg Arg Ser Glu Val Arg Ile Tyr Tyr Asp Tyr Thr Asp Val               
    345                 350                 355                           

gccttttatt gtttgttgga atcgatatgt acaaagtgta aataaatgtt tcttttcatt     1470

atccttgctt gagcccatca aaa                                             1493


<210>  22
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Phe Asn Leu Thr Leu Ala Lys Leu Pro Asn Asn Glu Leu His 
1               5                   10                  15      


Gly Gln Glu Ser His Asn Ser Gly Asn Arg Ser Asp Gly Pro Gly Lys 
            20                  25                  30          


Asn Thr Thr Leu His Asn Glu Phe Asp Thr Ile Val Leu Pro Val Leu 
        35                  40                  45              


Tyr Leu Ile Ile Phe Val Ala Ser Ile Leu Leu Asn Gly Leu Ala Val 
    50                  55                  60                  


Trp Ile Phe Phe His Ile Arg Asn Lys Thr Ser Phe Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys Asn Ile Val Val Ala Asp Leu Ile Met Thr Leu Thr Phe Pro Phe 
                85                  90                  95      


Arg Ile Val His Asp Ala Gly Phe Gly Pro Trp Tyr Phe Lys Phe Ile 
            100                 105                 110         


Leu Cys Arg Tyr Thr Ser Val Leu Phe Tyr Ala Asn Met Tyr Thr Ser 
        115                 120                 125             


Ile Val Phe Leu Gly Leu Ile Ser Ile Asp Arg Tyr Leu Lys Val Val 
    130                 135                 140                 


Lys Pro Phe Gly Asp Ser Arg Met Tyr Ser Ile Thr Phe Thr Lys Val 
145                 150                 155                 160 


Leu Ser Val Cys Val Trp Val Ile Met Ala Val Leu Ser Leu Pro Asn 
                165                 170                 175     


Ile Ile Leu Thr Asn Gly Gln Pro Thr Glu Asp Asn Ile His Asp Cys 
            180                 185                 190         


Ser Lys Leu Lys Ser Pro Leu Gly Val Lys Trp His Thr Ala Val Thr 
        195                 200                 205             


Tyr Val Asn Ser Cys Leu Phe Val Ala Val Leu Val Ile Leu Ile Gly 
    210                 215                 220                 


Cys Tyr Ile Ala Ile Ser Arg Tyr Ile His Lys Ser Ser Arg Gln Phe 
225                 230                 235                 240 


Ile Ser Gln Ser Ser Arg Lys Arg Lys His Asn Gln Ser Ile Arg Val 
                245                 250                 255     


Val Val Ala Val Phe Phe Thr Cys Phe Leu Pro Tyr His Leu Cys Arg 
            260                 265                 270         


Ile Pro Phe Thr Phe Ser His Leu Asp Arg Leu Leu Asp Glu Ser Ala 
        275                 280                 285             


Gln Lys Ile Leu Tyr Tyr Cys Lys Glu Ile Thr Leu Phe Leu Ser Ala 
    290                 295                 300                 


Cys Asn Val Cys Leu Asp Pro Ile Ile Tyr Phe Phe Met Cys Arg Ser 
305                 310                 315                 320 


Phe Ser Arg Arg Leu Phe Lys Lys Ser Asn Ile Arg Thr Arg Ser Glu 
                325                 330                 335     


Ser Ile Arg Ser Leu Gln Ser Val Arg Arg Ser Glu Val Arg Ile Tyr 
            340                 345                 350         


Tyr Asp Tyr Thr Asp Val 
        355             


<210>  23
<211>  4889
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (331)..(3486)

<400>  23
agatccgccg cgaagccggg atcgaaggcg acagcgcggc caagggggcg cggccgggac       60

aagctggggg ccggttgccc ggggcaggga cggcggcgac ccggccgctg gggaggcagg      120

aagatagacc cacggatctt aggaagggat ccgagagcgc agctgtgaaa ctggctgggg      180

ctgggggcac gaaaccgatc agcgctacgg agcgcagcgg ccggcgggtt ccagtgtcct      240

ccggcggcgc ggggagcagg tgaacaggtc ctcacgccca gctccgcgcc ctcacgcgct      300

ctcgccggga ccccgcttcc gctggcagcc atg ggc ccc ggc ccc agc cgc gcg       354
                                 Met Gly Pro Gly Pro Ser Arg Ala          
                                 1               5                        

ccc cgc gcc cca cgc ctg atg ctc tgt gcg ctc gcc ttg atg gtg gcg        402
Pro Arg Ala Pro Arg Leu Met Leu Cys Ala Leu Ala Leu Met Val Ala           
    10                  15                  20                            

gcc ggc ggc tgc gtc gtc tcc gcc ttc aac ctg gat acc cga ttc ctg        450
Ala Gly Gly Cys Val Val Ser Ala Phe Asn Leu Asp Thr Arg Phe Leu           
25                  30                  35                  40            

gta gtg aag gag gcc ggg aac ccg ggc agc ctc ttc ggc tac tcg gtc        498
Val Val Lys Glu Ala Gly Asn Pro Gly Ser Leu Phe Gly Tyr Ser Val           
                45                  50                  55                

gcc ctc cat cgg cag aca gag cgg cag cag cgc tac ctg ctc ctg gct        546
Ala Leu His Arg Gln Thr Glu Arg Gln Gln Arg Tyr Leu Leu Leu Ala           
            60                  65                  70                    

ggt gcc ccc cgg gag ctc gct gtg ccc gat ggc tac acc aac cgg act        594
Gly Ala Pro Arg Glu Leu Ala Val Pro Asp Gly Tyr Thr Asn Arg Thr           
        75                  80                  85                        

ggt gct gtg tac ctg tgc cca ctc act gcc cac aag gat gac tgt gag        642
Gly Ala Val Tyr Leu Cys Pro Leu Thr Ala His Lys Asp Asp Cys Glu           
    90                  95                  100                           

cgg atg aac atc aca gtg aaa aat gac cct ggc cat cac att att gag        690
Arg Met Asn Ile Thr Val Lys Asn Asp Pro Gly His His Ile Ile Glu           
105                 110                 115                 120           

gac atg tgg ctt gga gtg act gtg gcc agc cag ggc cct gca ggc aga        738
Asp Met Trp Leu Gly Val Thr Val Ala Ser Gln Gly Pro Ala Gly Arg           
                125                 130                 135               

gtt ctg gtc tgt gcc cac cgc tac acc cag gtg ctg tgg tca ggg tca        786
Val Leu Val Cys Ala His Arg Tyr Thr Gln Val Leu Trp Ser Gly Ser           
            140                 145                 150                   

gaa gac cag cgg cgc atg gtg ggc aag tgc tac gtg cga ggc aat gac        834
Glu Asp Gln Arg Arg Met Val Gly Lys Cys Tyr Val Arg Gly Asn Asp           
        155                 160                 165                       

cta gag ctg gac tcc agt gat gac tgg cag acc tac cac aac gag atg        882
Leu Glu Leu Asp Ser Ser Asp Asp Trp Gln Thr Tyr His Asn Glu Met           
    170                 175                 180                           

tgc aat agc aac aca gac tac ctg gag acg ggc atg tgc cag ctg ggc        930
Cys Asn Ser Asn Thr Asp Tyr Leu Glu Thr Gly Met Cys Gln Leu Gly           
185                 190                 195                 200           

acc agc ggt ggc ttc acc cag aac act gtg tac ttc ggc gcc ccc ggt        978
Thr Ser Gly Gly Phe Thr Gln Asn Thr Val Tyr Phe Gly Ala Pro Gly           
                205                 210                 215               

gcc tac aac tgg aaa gga aac agc tac atg att cag cgc aag gag tgg       1026
Ala Tyr Asn Trp Lys Gly Asn Ser Tyr Met Ile Gln Arg Lys Glu Trp           
            220                 225                 230                   

gac tta tct gag tat agt tac aag gac cca gag gac caa gga aac ctc       1074
Asp Leu Ser Glu Tyr Ser Tyr Lys Asp Pro Glu Asp Gln Gly Asn Leu           
        235                 240                 245                       

tat att ggg tac acg atg cag gta ggc agc ttc atc ctg cac ccc aaa       1122
Tyr Ile Gly Tyr Thr Met Gln Val Gly Ser Phe Ile Leu His Pro Lys           
    250                 255                 260                           

aac atc acc att gtg aca ggt gcc cca cgg cac cga cat atg ggc gcg       1170
Asn Ile Thr Ile Val Thr Gly Ala Pro Arg His Arg His Met Gly Ala           
265                 270                 275                 280           

gtg ttc ttg ctg agc cag gag gca ggc gga gac ctg cgg agg agg cag       1218
Val Phe Leu Leu Ser Gln Glu Ala Gly Gly Asp Leu Arg Arg Arg Gln           
                285                 290                 295               

gtg ctg gag ggc tcg cag gtg ggc gcc tat ttt ggc agc gcc att gcc       1266
Val Leu Glu Gly Ser Gln Val Gly Ala Tyr Phe Gly Ser Ala Ile Ala           
            300                 305                 310                   

ctg gca gac ctg aac aat gat ggg tgg cag gac ctc ctg gtg ggc gcc       1314
Leu Ala Asp Leu Asn Asn Asp Gly Trp Gln Asp Leu Leu Val Gly Ala           
        315                 320                 325                       

ccc tac tac ttc gag agg aaa gag gaa gta ggg ggt gcc atc tat gtc       1362
Pro Tyr Tyr Phe Glu Arg Lys Glu Glu Val Gly Gly Ala Ile Tyr Val           
    330                 335                 340                           

ttc atg aac cag gcg gga acc tcc ttc cct gct cac ccc tca ctc ctt       1410
Phe Met Asn Gln Ala Gly Thr Ser Phe Pro Ala His Pro Ser Leu Leu           
345                 350                 355                 360           

ctt cat ggc ccc agt ggc tct gcc ttt ggt tta tct gtg gcc agc att       1458
Leu His Gly Pro Ser Gly Ser Ala Phe Gly Leu Ser Val Ala Ser Ile           
                365                 370                 375               

ggt gac atc aac cag gat gga ttt cag gat att gct gtg gga gct ccg       1506
Gly Asp Ile Asn Gln Asp Gly Phe Gln Asp Ile Ala Val Gly Ala Pro           
            380                 385                 390                   

ttt gaa ggc ttg ggc aaa gtg tac atc tat cac agt agc tct aag ggg       1554
Phe Glu Gly Leu Gly Lys Val Tyr Ile Tyr His Ser Ser Ser Lys Gly           
        395                 400                 405                       

ctc ctt aga cag ccc cag cag gta atc cat gga gag aag ctg gga ctg       1602
Leu Leu Arg Gln Pro Gln Gln Val Ile His Gly Glu Lys Leu Gly Leu           
    410                 415                 420                           

cct ggg ttg gcc acc ttc ggc tat tcc ctc agt ggg cag atg gat gtg       1650
Pro Gly Leu Ala Thr Phe Gly Tyr Ser Leu Ser Gly Gln Met Asp Val           
425                 430                 435                 440           

gat gag aac ttc tac cca gac ctt cta gtg gga agc ctg tca gac cac       1698
Asp Glu Asn Phe Tyr Pro Asp Leu Leu Val Gly Ser Leu Ser Asp His           
                445                 450                 455               

att gtg ctg ctg cgg gcc cgg ccc gtc atc aac atc gtc cac aag acc       1746
Ile Val Leu Leu Arg Ala Arg Pro Val Ile Asn Ile Val His Lys Thr           
            460                 465                 470                   

ttg gtg ccc agg cca gct gtg ctg gac cct gca ctt tgc acg gcc acc       1794
Leu Val Pro Arg Pro Ala Val Leu Asp Pro Ala Leu Cys Thr Ala Thr           
        475                 480                 485                       

tct tgt gtg caa gtg gag ctg tgc ttt gct tac aac cag agt gcc ggg       1842
Ser Cys Val Gln Val Glu Leu Cys Phe Ala Tyr Asn Gln Ser Ala Gly           
    490                 495                 500                           

aac ccc aac tac agg cga aac atc acc ctg gcc tac act ctg gag gct       1890
Asn Pro Asn Tyr Arg Arg Asn Ile Thr Leu Ala Tyr Thr Leu Glu Ala           
505                 510                 515                 520           

gac agg gac cgc cgg ccg ccc cgg ctc cgc ttt gcc ggc agt gag tcc       1938
Asp Arg Asp Arg Arg Pro Pro Arg Leu Arg Phe Ala Gly Ser Glu Ser           
                525                 530                 535               

gct gtc ttc cac ggc ttc ttc tcc atg ccc gag atg cgc tgc cag aag       1986
Ala Val Phe His Gly Phe Phe Ser Met Pro Glu Met Arg Cys Gln Lys           
            540                 545                 550                   

ctg gag ctg ctc ctg atg gac aac ctc cgt gac aaa ctc cgc ccc atc       2034
Leu Glu Leu Leu Leu Met Asp Asn Leu Arg Asp Lys Leu Arg Pro Ile           
        555                 560                 565                       

atc atc tcc atg aac tac tct tta cct ttg cgg atg ccc gat cgc ccc       2082
Ile Ile Ser Met Asn Tyr Ser Leu Pro Leu Arg Met Pro Asp Arg Pro           
    570                 575                 580                           

cgg ctg ggg ctg cgg tcc ctg gac gcc tac ccg atc ctc aac cag gca       2130
Arg Leu Gly Leu Arg Ser Leu Asp Ala Tyr Pro Ile Leu Asn Gln Ala           
585                 590                 595                 600           

cag gct ctg gag aac cac act gag gtc cag ttc cag aag gag tgc ggg       2178
Gln Ala Leu Glu Asn His Thr Glu Val Gln Phe Gln Lys Glu Cys Gly           
                605                 610                 615               

cct gac aac aag tgt gag agc aac ttg cag atg cgg gca gcc ttc gtg       2226
Pro Asp Asn Lys Cys Glu Ser Asn Leu Gln Met Arg Ala Ala Phe Val           
            620                 625                 630                   

tca gag cag cag cag aag ctg agc agg ctc cag tac agc aga gac gtc       2274
Ser Glu Gln Gln Gln Lys Leu Ser Arg Leu Gln Tyr Ser Arg Asp Val           
        635                 640                 645                       

cgg aaa ttg ctc ctg agc atc aac gtg acg aac acc cgg acc tcg gag       2322
Arg Lys Leu Leu Leu Ser Ile Asn Val Thr Asn Thr Arg Thr Ser Glu           
    650                 655                 660                           

cgc tcc ggg gag gac gcc cac gag gcg ctg ctc acc ctg gtg gtg cct       2370
Arg Ser Gly Glu Asp Ala His Glu Ala Leu Leu Thr Leu Val Val Pro           
665                 670                 675                 680           

ccc gcc ctg ctg ctg tcc tca gtg cgc ccc ccc ggg gcc tgc caa gct       2418
Pro Ala Leu Leu Leu Ser Ser Val Arg Pro Pro Gly Ala Cys Gln Ala           
                685                 690                 695               

aat gag acc atc ttt tgc gag ctg ggg aac ccc ttc aaa cgg aac cag       2466
Asn Glu Thr Ile Phe Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Gln           
            700                 705                 710                   

agg atg gag ctg ctc atc gcc ttt gag gtc atc ggg gtg acc ctg cac       2514
Arg Met Glu Leu Leu Ile Ala Phe Glu Val Ile Gly Val Thr Leu His           
        715                 720                 725                       

aca agg gac ctt cag gtg cag ctg cag ctc tcc acg tcg agt cac cag       2562
Thr Arg Asp Leu Gln Val Gln Leu Gln Leu Ser Thr Ser Ser His Gln           
    730                 735                 740                           

gac aac ctg tgg ccc atg atc ctc act ctg ctg gtg gac tat aca ctc       2610
Asp Asn Leu Trp Pro Met Ile Leu Thr Leu Leu Val Asp Tyr Thr Leu           
745                 750                 755                 760           

cag acc tcg ctt agc atg gta aat cac cgg cta caa agc ttc ttt ggg       2658
Gln Thr Ser Leu Ser Met Val Asn His Arg Leu Gln Ser Phe Phe Gly           
                765                 770                 775               

ggg aca gtg atg ggt gag tct ggc atg aaa act gtg gag gat gta gga       2706
Gly Thr Val Met Gly Glu Ser Gly Met Lys Thr Val Glu Asp Val Gly           
            780                 785                 790                   

agc ccc ctc aag tat gaa ttc cag gtg ggc cca atg ggg gag ggg ctg       2754
Ser Pro Leu Lys Tyr Glu Phe Gln Val Gly Pro Met Gly Glu Gly Leu           
        795                 800                 805                       

gtg ggc ctg ggg acc ctg gtc cta ggt ctg gag tgg ccc tac gaa gtc       2802
Val Gly Leu Gly Thr Leu Val Leu Gly Leu Glu Trp Pro Tyr Glu Val           
    810                 815                 820                           

agc aat ggc aag tgg ctg ctg tat ccc acg gag atc acc gtc cat ggc       2850
Ser Asn Gly Lys Trp Leu Leu Tyr Pro Thr Glu Ile Thr Val His Gly           
825                 830                 835                 840           

aat ggg tcc tgg ccc tgc cga cca cct gga gac ctt atc aac cct ctc       2898
Asn Gly Ser Trp Pro Cys Arg Pro Pro Gly Asp Leu Ile Asn Pro Leu           
                845                 850                 855               

aac ctc act ctt tct gac cct ggg gac agg cca tca tcc cca cag cgc       2946
Asn Leu Thr Leu Ser Asp Pro Gly Asp Arg Pro Ser Ser Pro Gln Arg           
            860                 865                 870                   

agg cgg cga cag ctg gat cca ggg gga ggc cag ggc ccc cca cct gtc       2994
Arg Arg Arg Gln Leu Asp Pro Gly Gly Gly Gln Gly Pro Pro Pro Val           
        875                 880                 885                       

act ctg gct gct gcc aaa aaa gcc aag tct gag act gtg ctg acc tgt       3042
Thr Leu Ala Ala Ala Lys Lys Ala Lys Ser Glu Thr Val Leu Thr Cys           
    890                 895                 900                           

gcc aca ggg cgt gcc cac tgt gtg tgg cta gag tgc ccc atc cct gat       3090
Ala Thr Gly Arg Ala His Cys Val Trp Leu Glu Cys Pro Ile Pro Asp           
905                 910                 915                 920           

gcc ccc gtt gtc acc aac gtg act gtg aag gca cga gtg tgg aac agc       3138
Ala Pro Val Val Thr Asn Val Thr Val Lys Ala Arg Val Trp Asn Ser           
                925                 930                 935               

acc ttc atc gag gat tac aga gac ttt gac cga gtc cgg gta aat ggc       3186
Thr Phe Ile Glu Asp Tyr Arg Asp Phe Asp Arg Val Arg Val Asn Gly           
            940                 945                 950                   

tgg gct acc cta ttc ctc cga acc agc atc ccc acc atc aac atg gag       3234
Trp Ala Thr Leu Phe Leu Arg Thr Ser Ile Pro Thr Ile Asn Met Glu           
        955                 960                 965                       

aac aag acc acg tgg ttc tct gtg gac att gac tcg gag ctg gtg gag       3282
Asn Lys Thr Thr Trp Phe Ser Val Asp Ile Asp Ser Glu Leu Val Glu           
    970                 975                 980                           

gag ctg ccg gcc gaa atc gag ctg tgg ctg gtg ctg gtg gcc gtg ggt       3330
Glu Leu Pro Ala Glu Ile Glu Leu Trp Leu Val Leu Val Ala Val Gly           
985                 990                 995                 1000          

gca ggg ctg ctg ctg  ctg ggg ctg atc atc  ctc ctg ctg tgg aag         3375
Ala Gly Leu Leu Leu  Leu Gly Leu Ile Ile  Leu Leu Leu Trp Lys             
                1005                 1010                 1015            

tgc ggc ttc ttc aag  cga gcc cgc act cgc  gcc ctg tat gaa gct         3420
Cys Gly Phe Phe Lys  Arg Ala Arg Thr Arg  Ala Leu Tyr Glu Ala             
                1020                 1025                 1030            

aag agg cag aag gcg  gag atg aag agc cag  ccg tca gag aca gag         3465
Lys Arg Gln Lys Ala  Glu Met Lys Ser Gln  Pro Ser Glu Thr Glu             
                1035                 1040                 1045            

agg ctg acc gac gac  tac tga gggggcagcc ccccgccccc ggcccacctg         3516
Arg Leu Thr Asp Asp  Tyr                                                  
                1050                                                      

gtgtgacttc tttaagcgga cccgctatta tcagatcatg cccaagtacc acgcagtgcg     3576

gatccgggag gaggagcgct acccacctcc agggagcacc ctgcccacca agaagcactg     3636

ggtgaccagc tggcagactc gggaccaata ctactgacgt cctccctgat cccaccccct     3696

cctcccccag tgtccccttt cttcctattt atcataagtt atgcctctga cagtccacag     3756

gggccaccac ctttggctgg tagcagcagg ctcaggcaca tacacctcgt caagagcatg     3816

cacatgctgt ctggccctgg ggatcttccc acaggagggc cagcgctgtg gaccttacaa     3876

cgccgagtgc actgcattcc tgtgccctag atgcacgtgg ggcccactgc tcgtggactg     3936

tgctggtgca tcacggatgg tgcatgggct cgccgtgtct cagcctctgc cagcgccaaa     3996

acaagccaaa gagcctccca ccagagccgg gaggaaaagg cccctgcaat gtggtgacac     4056

ctcccccttt cacactggat ccatcttgag ccacagtcac tggattgact ttgctgtcaa     4116

aactactgac agggagcagc ccccgggccg ctggctggtg ggcccccaat gacacccatg     4176

ccagagaggt ggggatcctg cctaaggttg tctacggggg cacttggagg acctggcgtg     4236

ctcagaccca acagcaaagg aactagaaag aaggacccag aacggcttgc tttcctgcat     4296

ctctgtgaag cctctctcct tggccacaga ctgaactcgc agggaatgca gcaggaagga     4356

acaaagacag gcaaacggca acgtagcctg ggctcactgt gctggggcac ggcgggatcc     4416

tccacagaga ggaggggacc aattctggac agacagatgt tgggaggata cagaggagat     4476

gccacttctc actcaccact accagccagc ctcagaaggc cccagagaga ccctgcaaga     4536

ccacggaggg agcgacactt gaatgtagaa taggcagggg gccctgcccc accccatcca     4596

gccagacccc acgctgacca tgcgtcaggg gcctagaggt ggagttctta gctatccttg     4656

gctttcagag ccagcctggc tctgccccct cccccatggg ctgtgtccta aggcccattt     4716

gagaagctga ggctagttcc agaaaacctc tcctgacccc tgcctgttgg caggcccact     4776

ccccagcccc agccccttcc atggtactgt agcaggggaa ttccctcccc ctccttgtgc     4836

cttctttgta tataggcttc tcacggcgac caataaacag ctcccagttt gta            4889


<210>  24
<211>  1051
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  25
<211>  2238
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (99)..(1871)

<400>  25
aacagagcca ccttctgcgt cctgctgagc tctgttctct ccagcacctc ccaacccact       60

agtgcctggt tctcttgctc caccaggaac aagccacc atg tct cgc cag tca agt      116
                                          Met Ser Arg Gln Ser Ser         
                                          1               5               

gtg tcc ttc cgg agc ggg ggc agt cgt agc ttc agc acc gcc tct gcc        164
Val Ser Phe Arg Ser Gly Gly Ser Arg Ser Phe Ser Thr Ala Ser Ala           
            10                  15                  20                    

atc acc ccg tct gtc tcc cgc acc agc ttc acc tcc gtg tcc cgg tcc        212
Ile Thr Pro Ser Val Ser Arg Thr Ser Phe Thr Ser Val Ser Arg Ser           
        25                  30                  35                        

ggg ggt ggc ggt ggt ggt ggc ttc ggc agg gtc agc ctt gcg ggt gct        260
Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg Val Ser Leu Ala Gly Ala           
    40                  45                  50                            

tgt gga gtg ggt ggc tat ggc agc cgg agc ctc tac aac ctg ggg ggc        308
Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser Leu Tyr Asn Leu Gly Gly           
55                  60                  65                  70            

tcc aag agg ata tcc atc agc act agt ggt ggc agc ttc agg aac cgg        356
Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly Gly Ser Phe Arg Asn Arg           
                75                  80                  85                

ttt ggt gct ggt gct gga ggc ggc tat ggc ttt gga ggt ggt gcc ggt        404
Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly Phe Gly Gly Gly Ala Gly           
            90                  95                  100                   

agt gga ttt ggt ttc ggc ggt gga gct ggt ggt ggc ttt ggg ctc ggt        452
Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Gly Gly Phe Gly Leu Gly           
        105                 110                 115                       

ggc gga gct ggc ttt gga ggt ggc ttc ggt ggc cct ggc ttt cct gtc        500
Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly Gly Pro Gly Phe Pro Val           
    120                 125                 130                           

tgc cct cct gga ggt atc caa gag gtc act gtc aac cag agt ctc ctg        548
Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu Leu           
135                 140                 145                 150           

act ccc ctc aac ctg caa atc gac ccc agc atc cag agg gtg agg acc        596
Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser Ile Gln Arg Val Arg Thr           
                155                 160                 165               

gag gag cgc gag cag atc aag acc ctc aac aat aag ttt gcc tcc ttc        644
Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe           
            170                 175                 180                   

atc gac aag gtg cgg ttc ctg gag cag cag aac aag gtt ctg gac acc        692
Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp Thr           
        185                 190                 195                       

aag tgg acc ctg ctg cag gag cag ggc acc aag act gtg agg cag aac        740
Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln Asn           
    200                 205                 210                           

ctg gag ccg ttg ttc gag cag tac atc aac aac ctc agg agg cag ctg        788
Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln Leu           
215                 220                 225                 230           

gac agc atc gtg ggg gaa cgg ggc cgc ctg gac tca gag ctg aga aac        836
Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg Asn           
                235                 240                 245               

atg cag gac ctg gtg gaa gac ttc aag aac aag tat gag gat gaa atc        884
Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu Ile           
            250                 255                 260                   

aac aag cgt acc act gct gag aat gag ttt gtg atg ctg aag aag gat        932
Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe Val Met Leu Lys Lys Asp           
        265                 270                 275                       

gta gat gct gcc tac atg aac aag gtg gag ctg gag gcc aag gtt gat        980
Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Glu Ala Lys Val Asp           
    280                 285                 290                           

gca ctg atg gat gag att aac ttc atg aag atg ttc ttt gat gcg gag       1028
Ala Leu Met Asp Glu Ile Asn Phe Met Lys Met Phe Phe Asp Ala Glu           
295                 300                 305                 310           

ctg tcc cag atg cag acg cat gtc tct gac acc tca gtg gtc ctc tcc       1076
Leu Ser Gln Met Gln Thr His Val Ser Asp Thr Ser Val Val Leu Ser           
                315                 320                 325               

atg gac aac aac cgc aac ctg gac ctg gat agc atc atc gct gag gtc       1124
Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val           
            330                 335                 340                   

aag gcc cag tat gag gag att gcc aac cgc agc cgg aca gaa gcc gag       1172
Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg Ser Arg Thr Glu Ala Glu           
        345                 350                 355                       

tcc tgg tat cag acc aag tat gag gag ctg cag cag aca gct ggc cgg       1220
Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Gln Thr Ala Gly Arg           
    360                 365                 370                           

cat ggc gat gac ctc cgc aac acc aag cat gag atc tct gag atg aac       1268
His Gly Asp Asp Leu Arg Asn Thr Lys His Glu Ile Ser Glu Met Asn           
375                 380                 385                 390           

cgg atg atc cag agg ctg aga gcc gag att gac aat gtc aag aaa cag       1316
Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Asp Asn Val Lys Lys Gln           
                395                 400                 405               

tgc gcc aat ctg cag aac gcc att gcg gat gcc gag cag cgt ggg gag       1364
Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp Ala Glu Gln Arg Gly Glu           
            410                 415                 420                   

ctg gcc ctc aag gat gcc agg aac aag ctg gcc gag ctg gag gag gcc       1412
Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu Ala Glu Leu Glu Glu Ala           
        425                 430                 435                       

ctg cag aag gcc aag cag gac atg gcc cgg ctg ctg cgt gag tac cag       1460
Leu Gln Lys Ala Lys Gln Asp Met Ala Arg Leu Leu Arg Glu Tyr Gln           
    440                 445                 450                           

gag ctc atg aac acc aag ctg gcc ctg gac gtg gag atc gcc act tac       1508
Glu Leu Met Asn Thr Lys Leu Ala Leu Asp Val Glu Ile Ala Thr Tyr           
455                 460                 465                 470           

cgc aag ctg ctg gag ggc gag gaa tgc aga ctc agt gga gaa gga gtt       1556
Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Ser Gly Glu Gly Val           
                475                 480                 485               

gga cca gtc aac atc tct gtt gtc aca agc agt gtt tcc tct gga tat       1604
Gly Pro Val Asn Ile Ser Val Val Thr Ser Ser Val Ser Ser Gly Tyr           
            490                 495                 500                   

ggc agt ggc agt ggc tat ggc ggt ggc ctc ggt gga ggt ctt ggc ggc       1652
Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly           
        505                 510                 515                       

ggc ctc ggt gga ggt ctt gcc gga ggt agc agt gga agc tac tac tcc       1700
Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser Ser Gly Ser Tyr Tyr Ser           
    520                 525                 530                           

agc agc agt ggg ggt gtc ggc cta ggt ggt ggg ctc agt gtg ggg ggc       1748
Ser Ser Ser Gly Gly Val Gly Leu Gly Gly Gly Leu Ser Val Gly Gly           
535                 540                 545                 550           

tct ggc ttc agt gca agc agt ggc cga ggg ctg ggg gtg ggc ttt ggc       1796
Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly Leu Gly Val Gly Phe Gly           
                555                 560                 565               

agt ggc ggg ggt agc agc tcc agc gtc aaa ttt gtc tcc acc acc tcc       1844
Ser Gly Gly Gly Ser Ser Ser Ser Val Lys Phe Val Ser Thr Thr Ser           
            570                 575                 580                   

tcc tcc cgg aag agc ttc aag agc taa gaacctgctg caagtcactg             1891
Ser Ser Arg Lys Ser Phe Lys Ser                                           
        585                 590                                           

ccttccaagt gcagcaaccc agcccatgga gattgcctct tctaggcagt tgctcaagcc     1951

atgttttatc cttttctgga gagtagtcta gaccaagcca attgcagaac cacattcttt     2011

ggttcccagg agagccccat tcccagcccc tggtctcccg tgccgcagtt ctatattctg     2071

cttcaaatca gccttcaggt ttcccacagc atggcccctg ctgacacgag aacccaaagt     2131

tttcccaaat ctaaatcatc aaaacagaat ccccacccca atcccaaatt ttgttttggt     2191

tctaactacc tccagaatgt gttcaataaa atgcttttat aatataa                   2238


<210>  26
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  27
<211>  2308
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (70)..(1764)

<400>  27
agtcctgctt ctcttccctc tctcctccag cctctcacac tctcctcagc tctctcatct       60

cctggaacc atg gcc agc aca tcc acc acc atc agg agc cac agc agc agc      111
          Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser         
          1               5                   10                          

cgc cgg ggt ttc agt gcc aac tca gcc agg ctc cct ggg gtc agc cgc        159
Arg Arg Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg           
15                  20                  25                  30            

tct ggc ttc agc agc gtc tcc gtg tcc cgc tcc agg ggc agt ggt ggc        207
Ser Gly Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly           
                35                  40                  45                

ctg ggt ggt gca tgt gga gga gct ggc ttt ggc agc cgc agt ctg tat        255
Leu Gly Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr           
            50                  55                  60                    

ggc ctg ggg ggc tcc aag agg atc tcc att gga ggg ggc agc tgt gcc        303
Gly Leu Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala           
        65                  70                  75                        

atc agt ggc ggc tat ggc agc aga gcc gga ggc agc tat ggc ttt ggt        351
Ile Ser Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly           
    80                  85                  90                            

ggc gcc ggg agt gga ttt ggt ttc ggt ggt gga gcc ggc att ggc ttt        399
Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe           
95                  100                 105                 110           

ggt ctg ggt ggt gga gcc ggc ctt gct ggt ggc ttt ggg ggc cct ggc        447
Gly Leu Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly           
                115                 120                 125               

ttc cct gtg tgc ccc cct gga ggc atc caa gag gtc acc gtc aac cag        495
Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln           
            130                 135                 140                   

agt ctc ctg act ccc ctc aac ctg caa atc gat ccc acc atc cag cgg        543
Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg           
        145                 150                 155                       

gtg cgg gct gag gag cgt gaa cag atc aag acc ctc aac aac aag ttt        591
Val Arg Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe           
    160                 165                 170                           

gcc tcc ttc atc gac aag gtg cgg ttc ctg gag cag cag aac aag gtt        639
Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val           
175                 180                 185                 190           

ctg gaa aca aag tgg acc ctg ctg cag gag cag ggc acc aag act gtg        687
Leu Glu Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val           
                195                 200                 205               

agg cag aac ctg gag ccg ttg ttc gag cag tac atc aac aac ctc agg        735
Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg           
            210                 215                 220                   

agg cag ctg gac agc att gtc ggg gaa cgg ggc cgc ctg gac tca gag        783
Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu           
        225                 230                 235                       

ctc aga ggc atg cag gac ctg gtg gag gac ttc aag aac aaa tat gag        831
Leu Arg Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu           
    240                 245                 250                           

gat gaa atc aac aag cgc aca gca gca gag aat gaa ttt gtg act ctg        879
Asp Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu           
255                 260                 265                 270           

aag aag gat gtg gat gct gcc tac atg aac aag gtt gaa ctg caa gcc        927
Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala           
                275                 280                 285               

aag gca gac act ctc aca gac gag atc aac ttc ctg aga gcc ttg tat        975
Lys Ala Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr           
            290                 295                 300                   

gat gca gag ctg tcc cag atg cag acc cac atc tca gac aca tct gtg       1023
Asp Ala Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val           
        305                 310                 315                       

gtg ctg tcc atg gac aac aac cgc aac ctg gac ctg gac agc atc atc       1071
Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile           
    320                 325                 330                           

gct gag gtc aag gcc caa tat gag gag att gct cag aga agc cgg gct       1119
Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala           
335                 340                 345                 350           

gag gct gag tcc tgg tac cag acc aag tac gag gag ctg cag gtc aca       1167
Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr           
                355                 360                 365               

gca ggc aga cat ggg gac gac ctg cgc aac acc aag cag gag att gct       1215
Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala           
            370                 375                 380                   

gag atc aac cgc atg atc cag agg ctg aga tct gag atc gac cac gtc       1263
Glu Ile Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val           
        385                 390                 395                       

aag aag cag tgc gcc aac ctg cag gcc gcc att gct gat gct gag cag       1311
Lys Lys Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln           
    400                 405                 410                           

cgt ggg gag atg gcc ctc aag gat gcc aag aac aag ctg gaa ggg ctg       1359
Arg Gly Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu           
415                 420                 425                 430           

gag gat gcc ctg cag aag gcc aag cag gac ctg gcc cgg ctg ctg aag       1407
Glu Asp Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys           
                435                 440                 445               

gag tac cag gag ctg atg aat gtc aag ctg gcc ctg gac gtg gag atc       1455
Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile           
            450                 455                 460                   

gcc acc tac cgc aag ctg ctg gag ggt gag gag tgc agg ctg aat ggc       1503
Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly           
        465                 470                 475                       

gaa ggc gtt gga caa gtc aac atc tct gtg gtg cag tcc acc gtc tcc       1551
Glu Gly Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser           
    480                 485                 490                           

agt ggc tat ggc ggt gcc agt ggt gtc ggc agt ggc tta ggc ctg ggt       1599
Ser Gly Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly           
495                 500                 505                 510           

gga gga agc agc tac tcc tat ggc agt ggt ctt ggc gtt gga ggt ggc       1647
Gly Gly Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly           
                515                 520                 525               

ttc agt tcc agc agt ggc aga gcc att ggg ggt ggc ctc agc tct gtt       1695
Phe Ser Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val           
            530                 535                 540                   

gga ggc ggc agt tcc acc atc aag tac acc acc acc tcc tcc tcc agc       1743
Gly Gly Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser           
        545                 550                 555                       

agg aag agc tat aag cac taa agtgcgtctg ctagctctcg gtcccacagt          1794
Arg Lys Ser Tyr Lys His                                                   
    560                                                                   

cctcaggccc ctctctggct gcagagccct ctcctcaggt tgcctttcct ctcctggcct     1854

ccagtctccc ctgctgtccc aggtagagct gggtatggat gcttagtgcc ctcacttctt     1914

ctctctctct ctataccatc tgagcaccca ttgctcacca tcagatcaac ctctgatttt     1974

acatcatgat gtaatcacca ctggagcttc actgttacta aattattaat ttcttgcctc     2034

cagtgttcta tctctgaggc tgagcattat aagaaaatga cctctgctcc ttttcattgc     2094

agaaaattgc caggggctta tttcagaaca acttccactt actttccact ggctctcaaa     2154

ctctctaact tataagtgtt gtgaaccccc acccaggcag tatccatgaa agcacaagtg     2214

actagtccta tgatgtacaa agcctgtatc tctgtgatga tttctgtgct cttcgctgtt     2274

tgcaattgct aaataaagca gatttataat acaa                                 2308


<210>  28
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  29
<211>  1712
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (64)..(1434)

<400>  29
ctggtacctc ctgccagcat ctcttgggtt tgctgagaac tcacgggctc cagctacctg       60

gcc atg acc acc aca ttt ctg caa act tct tcc tcc acc ttt ggg ggt        108
    Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly           
    1               5                   10                  15            

ggc tca acc cga ggg ggt tcc ctc ctg gct ggg gga ggt ggc ttt ggt        156
Gly Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly           
                20                  25                  30                

ggg ggg agt ctc tct ggg gga ggt gga agc cga agt atc tca gct tct        204
Gly Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser           
            35                  40                  45                    

tct gct agg ttt gtc tct tca ggg tca gga gga gga tat ggg ggt ggc        252
Ser Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly           
        50                  55                  60                        

atg agg gtc tgt ggc ttt ggt gga ggg gct ggt agt gtt ttc ggt gga        300
Met Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly           
    65                  70                  75                            

ggc ttt gga ggg ggc gtt ggt ggg ggt ttt ggt ggt ggc ttt ggt ggt        348
Gly Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly           
80                  85                  90                  95            

ggc gat ggt ggt ctc ctc tct ggc aat gag aaa att acc atg cag aac        396
Gly Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn           
                100                 105                 110               

ctc aat gac cgc ctg gcc tcc tac ctg gac aag gta cgt gcc ctg gag        444
Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu           
            115                 120                 125                   

gag gcc aat gct gac ctg gag gtg aag atc cat gac tgg tac cag aag        492
Glu Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys           
        130                 135                 140                       

cag acc cca acc agc cca gaa tgc gac tac agc caa tac ttc aag acc        540
Gln Thr Pro Thr Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr           
    145                 150                 155                           

att gaa gag ctc cgg gac aag atc atg gcc acc acc atc gac aac tcc        588
Ile Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser           
160                 165                 170                 175           

cgg gtc atc ctg gag atc gac aat gcc agg ctg gct gcg gac gac ttc        636
Arg Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe           
                180                 185                 190               

agg ctc aag tat gag aat gag ctg gcc ctg cgc cag ggc gtt gag gct        684
Arg Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala           
            195                 200                 205                   

gac atc aac ggc ttg cgc cga gtc ctg gat gag ctg acc ctg gcc agg        732
Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg           
        210                 215                 220                       

act gac ctg gag atg cag atc gag ggc ctg aat gag gag cta gcc tac        780
Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr           
    225                 230                 235                           

ctg aag aag aac cac gaa gag gag atg aag gag ttc agc agc cag ctg        828
Leu Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu           
240                 245                 250                 255           

gcc ggc cag gtc aat gtg gag atg gac gca gca ccg ggt gtg gac ctg        876
Ala Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu           
                260                 265                 270               

acc cgt gtg ctg gca gag atg agg gag cag tac gag gcc atg gcg gag        924
Thr Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu           
            275                 280                 285                   

aag aac cgc cgg gat gtc gag gcc tgg ttc ttc agc aag act gag gag        972
Lys Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu           
        290                 295                 300                       

ctg aac aaa gag gtg gcc tcc aac aca gaa atg atc cag acc agc aag       1020
Leu Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys           
    305                 310                 315                           

acg gag atc aca gac ctg aga cgc acg atg cag gag ctg gag atc gag       1068
Thr Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu           
320                 325                 330                 335           

ctg cag tcc cag ctc agc atg aaa gct ggg ctg gag aac tca ctg gcc       1116
Leu Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala           
                340                 345                 350               

gag aca gag tgc cgc tat gcc acg cag ctg cag cag atc cag ggg ctc       1164
Glu Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu           
            355                 360                 365                   

att ggt ggc ctg gag gcc cag ctg agt gag ctc cga tgc gag atg gag       1212
Ile Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu           
        370                 375                 380                       

gct cag aac cag gag tac aag atg ctg ctt gac ata aag aca cgg ctg       1260
Ala Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu           
    385                 390                 395                           

gag cag gag atc gct act tac cgc agc ctg ctc gag ggc cag gat gcc       1308
Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala           
400                 405                 410                 415           

aag atg gct ggc att gcc atc agg gaa gcc tct tca gga ggt ggt ggt       1356
Lys Met Ala Gly Ile Ala Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly           
                420                 425                 430               

agc agc agc aat ttc cac atc aat gta gaa gag tca gtg gat gga cag       1404
Ser Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln           
            435                 440                 445                   

gtg gtt tct tcc cac aag aga gaa atc taa gtgtctattg caggagaaac         1454
Val Val Ser Ser His Lys Arg Glu Ile                                       
        450                 455                                           

gtcccttgcc actccccact ctcatcaggc caagtggagg actggccaga gggcctgcac     1514

atgcaaactc cagtccctgc cttcagagag ctgaaaaggg tccctcggtc ttttatttca     1574

gggctttgca tgcgctctat tccccctctg cctctcccca ccttctttgg agcaaggaga     1634

tgcagctgta ttgtgtaaca agctcatttg tacagtgtct gttcatgtaa taaagaatta     1694

cttttccttt tgcaaata                                                   1712


<210>  30
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly Gly 
1               5                   10                  15      


Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser Ser 
        35                  40                  45              


Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly Met 
    50                  55                  60                  


Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly 
                85                  90                  95      


Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn Leu 
            100                 105                 110         


Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu 
        115                 120                 125             


Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys Gln 
    130                 135                 140                 


Thr Pro Thr Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser Arg 
                165                 170                 175     


Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg 
            180                 185                 190         


Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala Asp 
        195                 200                 205             


Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr 
    210                 215                 220                 


Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr Leu 
225                 230                 235                 240 


Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu Ala 
                245                 250                 255     


Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Thr 
            260                 265                 270         


Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Lys 
        275                 280                 285             


Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu Leu 
    290                 295                 300                 


Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys Thr 
305                 310                 315                 320 


Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu Leu 
                325                 330                 335     


Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala Glu 
            340                 345                 350         


Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu Ile 
        355                 360                 365             


Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu Ala 
    370                 375                 380                 


Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu 
385                 390                 395                 400 


Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys 
                405                 410                 415     


Met Ala Gly Ile Ala Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln Val 
        435                 440                 445             


Val Ser Ser His Lys Arg Glu Ile 
    450                 455     


<210>  31
<211>  1517
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(1365)

<400>  31
acacaacttg gggcccctct cctctccagc ccttctcctg tgtgcctgcc tcctgccgcc       60

gccacc atg acc acc tcc atc cgc cag ttc acc tcc tcc agc tcc atc         108
       Met Thr Thr Ser Ile Arg Gln Phe Thr Ser Ser Ser Ser Ile            
       1               5                   10                             

aag ggc tcc tcc ggc ctg ggg ggc ggc tcg tcc cgc acc tcc tgc cgg        156
Lys Gly Ser Ser Gly Leu Gly Gly Gly Ser Ser Arg Thr Ser Cys Arg           
15                  20                  25                  30            

ctg tct ggc ggc ctg ggt gcc ggc tcc tgc agg ctg gga tct gct ggc        204
Leu Ser Gly Gly Leu Gly Ala Gly Ser Cys Arg Leu Gly Ser Ala Gly           
                35                  40                  45                

ggc ctg ggc agc acc ctc ggg ggt agc agc tac tcc agc tgc tac agc        252
Gly Leu Gly Ser Thr Leu Gly Gly Ser Ser Tyr Ser Ser Cys Tyr Ser           
            50                  55                  60                    

ttt ggc tct ggt ggt ggc tat ggc agc agc ttt ggg ggt gtt gat ggg        300
Phe Gly Ser Gly Gly Gly Tyr Gly Ser Ser Phe Gly Gly Val Asp Gly           
        65                  70                  75                        

ctg ctg gct gga ggt gag aag gcc acc atg cag aac ctc aat gac cgc        348
Leu Leu Ala Gly Gly Glu Lys Ala Thr Met Gln Asn Leu Asn Asp Arg           
    80                  85                  90                            

ctg gcc tcc tac ctg gac aag gtg cgt gcc ctg gag gag gcc aac act        396
Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Thr           
95                  100                 105                 110           

gag ctg gag gtg aag atc cgt gac tgg tac cag agg cag gcc ccg ggg        444
Glu Leu Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Ala Pro Gly           
                115                 120                 125               

ccc gcc cgt gac tac agc cag tac tac agg aca att gag gag ctg cag        492
Pro Ala Arg Asp Tyr Ser Gln Tyr Tyr Arg Thr Ile Glu Glu Leu Gln           
            130                 135                 140                   

aac aag atc ctc aca gcc acc gtg gac aat gcc aac atc ctg cta cag        540
Asn Lys Ile Leu Thr Ala Thr Val Asp Asn Ala Asn Ile Leu Leu Gln           
        145                 150                 155                       

att gac aat gcc cgt ctg gct gct gat gac ttc cgc acc aag ttt gag        588
Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu           
    160                 165                 170                           

aca gag cag gcc ctg cgc ctg agt gtg gag gcc gac atc aat ggc ctg        636
Thr Glu Gln Ala Leu Arg Leu Ser Val Glu Ala Asp Ile Asn Gly Leu           
175                 180                 185                 190           

cgc agg gtg ctg gat gag ctg acc ctg gcc aga gcc gac ctg gag atg        684
Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met           
                195                 200                 205               

cag att gag aac ctc aag gag gag ctg gcc tac ctg aag aag aac cac        732
Gln Ile Glu Asn Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His           
            210                 215                 220                   

gag gag gag atg aac gcc ctg cga ggc cag gtg ggt ggt gag atc aat        780
Glu Glu Glu Met Asn Ala Leu Arg Gly Gln Val Gly Gly Glu Ile Asn           
        225                 230                 235                       

gtg gag atg gac gct gcc cca ggc gtg gac ctg agc cgc atc ctc aac        828
Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn           
    240                 245                 250                           

gag atg cgt gac cag tat gag aag atg gca gag aag aac cgc aag gat        876
Glu Met Arg Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp           
255                 260                 265                 270           

gcc gag gat tgg ttc ttc agc aag aca gag gaa ctg aac cgc gag gtg        924
Ala Glu Asp Trp Phe Phe Ser Lys Thr Glu Glu Leu Asn Arg Glu Val           
                275                 280                 285               

gcc acc aac agt gag ctg gtg cag agt ggc aag agt gag atc tcg gag        972
Ala Thr Asn Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu           
            290                 295                 300                   

ctc cgg cgc acc atg cag gcc ttg gag ata gag ctg cag tcc cag ctc       1020
Leu Arg Arg Thr Met Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu           
        305                 310                 315                       

agc atg aaa gca tcc ctg gag ggc aac ctg gcg gag aca gag aac cgc       1068
Ser Met Lys Ala Ser Leu Glu Gly Asn Leu Ala Glu Thr Glu Asn Arg           
    320                 325                 330                           

tac tgc gtg cag ctg tcc cag atc cag ggg ctg att ggc agc gtg gag       1116
Tyr Cys Val Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu           
335                 340                 345                 350           

gag cag ctg gcc cag ctt cgc tgc gag atg gag cag cag aac cag gaa       1164
Glu Gln Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu           
                355                 360                 365               

tac aaa atc ctg ctg gat gtg aag acg cgg ctg gag cag gag att gcc       1212
Tyr Lys Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala           
            370                 375                 380                   

acc tac cgc cgc ctg ctg gag gga gag gat gcc cac ctg act cag tac       1260
Thr Tyr Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Thr Gln Tyr           
        385                 390                 395                       

aag aaa gaa ccg gtg acc acc cgt cag gtg cgt acc att gtg gaa gag       1308
Lys Lys Glu Pro Val Thr Thr Arg Gln Val Arg Thr Ile Val Glu Glu           
    400                 405                 410                           

gtc cag gat ggc aag gtc atc tcc tcc cgc gag cag gtc cac cag acc       1356
Val Gln Asp Gly Lys Val Ile Ser Ser Arg Glu Gln Val His Gln Thr           
415                 420                 425                 430           

acc cgc tga ggactcagct accccggccg gccacccagg aggcagggag               1405
Thr Arg                                                                   
                                                                          

gcagccgccc catctgcccc acagtctccg gcctctccag cctcagcccc ctgcttcagt     1465

cccttcccca tgcttccttg cctgatgaca ataaagcttg ttgactcagc ta             1517


<210>  32
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Thr Ser Ile Arg Gln Phe Thr Ser Ser Ser Ser Ile Lys Gly 
1               5                   10                  15      


Ser Ser Gly Leu Gly Gly Gly Ser Ser Arg Thr Ser Cys Arg Leu Ser 
            20                  25                  30          


Gly Gly Leu Gly Ala Gly Ser Cys Arg Leu Gly Ser Ala Gly Gly Leu 
        35                  40                  45              


Gly Ser Thr Leu Gly Gly Ser Ser Tyr Ser Ser Cys Tyr Ser Phe Gly 
    50                  55                  60                  


Ser Gly Gly Gly Tyr Gly Ser Ser Phe Gly Gly Val Asp Gly Leu Leu 
65                  70                  75                  80  


Ala Gly Gly Glu Lys Ala Thr Met Gln Asn Leu Asn Asp Arg Leu Ala 
                85                  90                  95      


Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Thr Glu Leu 
            100                 105                 110         


Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Ala Pro Gly Pro Ala 
        115                 120                 125             


Arg Asp Tyr Ser Gln Tyr Tyr Arg Thr Ile Glu Glu Leu Gln Asn Lys 
    130                 135                 140                 


Ile Leu Thr Ala Thr Val Asp Asn Ala Asn Ile Leu Leu Gln Ile Asp 
145                 150                 155                 160 


Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu 
                165                 170                 175     


Gln Ala Leu Arg Leu Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg 
            180                 185                 190         


Val Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile 
        195                 200                 205             


Glu Asn Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu 
    210                 215                 220                 


Glu Met Asn Ala Leu Arg Gly Gln Val Gly Gly Glu Ile Asn Val Glu 
225                 230                 235                 240 


Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met 
                245                 250                 255     


Arg Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu 
            260                 265                 270         


Asp Trp Phe Phe Ser Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr 
        275                 280                 285             


Asn Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg 
    290                 295                 300                 


Arg Thr Met Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met 
305                 310                 315                 320 


Lys Ala Ser Leu Glu Gly Asn Leu Ala Glu Thr Glu Asn Arg Tyr Cys 
                325                 330                 335     


Val Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu Glu Gln 
            340                 345                 350         


Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys 
        355                 360                 365             


Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr 
    370                 375                 380                 


Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Thr Gln Tyr Lys Lys 
385                 390                 395                 400 


Glu Pro Val Thr Thr Arg Gln Val Arg Thr Ile Val Glu Glu Val Gln 
                405                 410                 415     


Asp Gly Lys Val Ile Ser Ser Arg Glu Gln Val His Gln Thr Thr Arg 
            420                 425                 430         


<210>  33
<211>  1121
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (60)..(1031)

<400>  33
accatctccc actcctgcag ctcttctcac aggaccagcc actagcgcag cctcgagcg        59

atg gcc tat gtc ccc gca ccg ggc tac cag ccc acc tac aac ccg acg        107
Met Ala Tyr Val Pro Ala Pro Gly Tyr Gln Pro Thr Tyr Asn Pro Thr           
1               5                   10                  15                

ctg cct tac tac cag ccc atc ccg ggc ggg ctc aac gtg gga atg tct        155
Leu Pro Tyr Tyr Gln Pro Ile Pro Gly Gly Leu Asn Val Gly Met Ser           
            20                  25                  30                    

gtt tac atc caa gga gtg gcc agc gag cac atg aag cgg ttc ttc gtg        203
Val Tyr Ile Gln Gly Val Ala Ser Glu His Met Lys Arg Phe Phe Val           
        35                  40                  45                        

aac ttt gtg gtt ggg cag gat ccg ggc tca gac gtc gcc ttc cac ttc        251
Asn Phe Val Val Gly Gln Asp Pro Gly Ser Asp Val Ala Phe His Phe           
    50                  55                  60                            

aat ccg cgg ttt gac ggc tgg gac aag gtg gtc ttc aac acg ttg cag        299
Asn Pro Arg Phe Asp Gly Trp Asp Lys Val Val Phe Asn Thr Leu Gln           
65                  70                  75                  80            

ggc ggg aag tgg ggc agc gag gag agg aag agg agc atg ccc ttc aaa        347
Gly Gly Lys Trp Gly Ser Glu Glu Arg Lys Arg Ser Met Pro Phe Lys           
                85                  90                  95                

aag ggt gcc gcc ttt gag ctg gtc ttc ata gtc ctg gct gag cac tac        395
Lys Gly Ala Ala Phe Glu Leu Val Phe Ile Val Leu Ala Glu His Tyr           
            100                 105                 110                   

aag gtg gtg gta aat gga aat ccc ttc tat gag tac ggg cac cgg ctt        443
Lys Val Val Val Asn Gly Asn Pro Phe Tyr Glu Tyr Gly His Arg Leu           
        115                 120                 125                       

ccc cta cag atg gtc acc cac ctg caa gtg gat ggg gat ctg caa ctt        491
Pro Leu Gln Met Val Thr His Leu Gln Val Asp Gly Asp Leu Gln Leu           
    130                 135                 140                           

caa tca atc aac ttc atc gga ggc cag ccc ctc cgg ccc cag gga ccc        539
Gln Ser Ile Asn Phe Ile Gly Gly Gln Pro Leu Arg Pro Gln Gly Pro           
145                 150                 155                 160           

ccg atg atg cca cct tac cct ggt ccc gga cat tgc cat caa cag ctg        587
Pro Met Met Pro Pro Tyr Pro Gly Pro Gly His Cys His Gln Gln Leu           
                165                 170                 175               

aac agc ctg ccc acc atg gaa gga ccc cca acc ttc aac ccg cct gtg        635
Asn Ser Leu Pro Thr Met Glu Gly Pro Pro Thr Phe Asn Pro Pro Val           
            180                 185                 190                   

cca tat ttc ggg agg ctg caa gga ggg ctc aca gct cga aga acc atc        683
Pro Tyr Phe Gly Arg Leu Gln Gly Gly Leu Thr Ala Arg Arg Thr Ile           
        195                 200                 205                       

atc atc aag ggc tat gtg cct ccc aca ggc aag agc ttt gct atc aac        731
Ile Ile Lys Gly Tyr Val Pro Pro Thr Gly Lys Ser Phe Ala Ile Asn           
    210                 215                 220                           

ttc aag gtg ggc tcc tca ggg gac ata gct ctg cac att aat ccc cgc        779
Phe Lys Val Gly Ser Ser Gly Asp Ile Ala Leu His Ile Asn Pro Arg           
225                 230                 235                 240           

atg ggc aac ggt acc gtg gtc cgg aac agc ctt ctg aat ggc tcg tgg        827
Met Gly Asn Gly Thr Val Val Arg Asn Ser Leu Leu Asn Gly Ser Trp           
                245                 250                 255               

gga tcc gag gag aag aag atc acc cac aac cca ttt ggt ccc gga cag        875
Gly Ser Glu Glu Lys Lys Ile Thr His Asn Pro Phe Gly Pro Gly Gln           
            260                 265                 270                   

ttc ttt gat ctg tcc att cgc tgt ggc ttg gat cgc ttc aag gtt tac        923
Phe Phe Asp Leu Ser Ile Arg Cys Gly Leu Asp Arg Phe Lys Val Tyr           
        275                 280                 285                       

gcc aat ggc cag cac ctc ttt gac ttt gcc cat cgc ctc tcg gcc ttc        971
Ala Asn Gly Gln His Leu Phe Asp Phe Ala His Arg Leu Ser Ala Phe           
    290                 295                 300                           

cag agg gtg gac aca ttg gaa atc cag ggt gat gtc acc ttg tcc tat       1019
Gln Arg Val Asp Thr Leu Glu Ile Gln Gly Asp Val Thr Leu Ser Tyr           
305                 310                 315                 320           

gtc cag atc taa tctattcctg gggccataac tcatgggaaa acagaattat           1071
Val Gln Ile                                                               
                                                                          

cccctaggac tcctttctaa gcccctaata aaatgtctga gggtgtctca                1121


<210>  34
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Tyr Val Pro Ala Pro Gly Tyr Gln Pro Thr Tyr Asn Pro Thr 
1               5                   10                  15      


Leu Pro Tyr Tyr Gln Pro Ile Pro Gly Gly Leu Asn Val Gly Met Ser 
            20                  25                  30          


Val Tyr Ile Gln Gly Val Ala Ser Glu His Met Lys Arg Phe Phe Val 
        35                  40                  45              


Asn Phe Val Val Gly Gln Asp Pro Gly Ser Asp Val Ala Phe His Phe 
    50                  55                  60                  


Asn Pro Arg Phe Asp Gly Trp Asp Lys Val Val Phe Asn Thr Leu Gln 
65                  70                  75                  80  


Gly Gly Lys Trp Gly Ser Glu Glu Arg Lys Arg Ser Met Pro Phe Lys 
                85                  90                  95      


Lys Gly Ala Ala Phe Glu Leu Val Phe Ile Val Leu Ala Glu His Tyr 
            100                 105                 110         


Lys Val Val Val Asn Gly Asn Pro Phe Tyr Glu Tyr Gly His Arg Leu 
        115                 120                 125             


Pro Leu Gln Met Val Thr His Leu Gln Val Asp Gly Asp Leu Gln Leu 
    130                 135                 140                 


Gln Ser Ile Asn Phe Ile Gly Gly Gln Pro Leu Arg Pro Gln Gly Pro 
145                 150                 155                 160 


Pro Met Met Pro Pro Tyr Pro Gly Pro Gly His Cys His Gln Gln Leu 
                165                 170                 175     


Asn Ser Leu Pro Thr Met Glu Gly Pro Pro Thr Phe Asn Pro Pro Val 
            180                 185                 190         


Pro Tyr Phe Gly Arg Leu Gln Gly Gly Leu Thr Ala Arg Arg Thr Ile 
        195                 200                 205             


Ile Ile Lys Gly Tyr Val Pro Pro Thr Gly Lys Ser Phe Ala Ile Asn 
    210                 215                 220                 


Phe Lys Val Gly Ser Ser Gly Asp Ile Ala Leu His Ile Asn Pro Arg 
225                 230                 235                 240 


Met Gly Asn Gly Thr Val Val Arg Asn Ser Leu Leu Asn Gly Ser Trp 
                245                 250                 255     


Gly Ser Glu Glu Lys Lys Ile Thr His Asn Pro Phe Gly Pro Gly Gln 
            260                 265                 270         


Phe Phe Asp Leu Ser Ile Arg Cys Gly Leu Asp Arg Phe Lys Val Tyr 
        275                 280                 285             


Ala Asn Gly Gln His Leu Phe Asp Phe Ala His Arg Leu Ser Ala Phe 
    290                 295                 300                 


Gln Arg Val Asp Thr Leu Glu Ile Gln Gly Asp Val Thr Leu Ser Tyr 
305                 310                 315                 320 


Val Gln Ile 
            


<210>  35
<211>  1490
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (29)..(475)

<400>  35
agcctagcac tctgacctag cagtcaac atg aag gct ctc att gtt ctg ggg          52
                               Met Lys Ala Leu Ile Val Leu Gly            
                               1               5                          

ctt gtc ctc ctt tct gtt acg gtc cag ggc aag gtc ttt gaa agg tgt        100
Leu Val Leu Leu Ser Val Thr Val Gln Gly Lys Val Phe Glu Arg Cys           
    10                  15                  20                            

gag ttg gcc aga act ctg aaa aga ttg gga atg gat ggc tac agg gga        148
Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly Met Asp Gly Tyr Arg Gly           
25                  30                  35                  40            

atc agc cta gca aac tgg atg tgt ttg gcc aaa tgg gag agt ggt tac        196
Ile Ser Leu Ala Asn Trp Met Cys Leu Ala Lys Trp Glu Ser Gly Tyr           
                45                  50                  55                

aac aca cga gct aca aac tac aat gct gga gac aga agc act gat tat        244
Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly Asp Arg Ser Thr Asp Tyr           
            60                  65                  70                    

ggg ata ttt cag atc aat agc cgc tac tgg tgt aat gat ggc aaa acc        292
Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp Cys Asn Asp Gly Lys Thr           
        75                  80                  85                        

cca gga gca gtt aat gcc tgt cat tta tcc tgc agt gct ttg ctg caa        340
Pro Gly Ala Val Asn Ala Cys His Leu Ser Cys Ser Ala Leu Leu Gln           
    90                  95                  100                           

gat aac atc gct gat gct gta gct tgt gca aag agg gtt gtc cgt gat        388
Asp Asn Ile Ala Asp Ala Val Ala Cys Ala Lys Arg Val Val Arg Asp           
105                 110                 115                 120           

cca caa ggc att aga gca tgg gtg gca tgg aga aat cgt tgt caa aac        436
Pro Gln Gly Ile Arg Ala Trp Val Ala Trp Arg Asn Arg Cys Gln Asn           
                125                 130                 135               

aga gat gtc cgt cag tat gtt caa ggt tgt gga gtg taa ctccagaatt         485
Arg Asp Val Arg Gln Tyr Val Gln Gly Cys Gly Val                           
            140                 145                                       

ttccttcttc agctcatttt gtctctctca cattaaggga gtaggaatta agtgaaaggt      545

cacactacca ttatttcccc ttcaaacaaa taatattttt acagaagcag gagcaaaata      605

tggcctttct tctaagagat ataatgttca ctaatgtggt tattttacat taagcctaca      665

acatttttca gtttgcaaat agaactaata ctggtgaaaa tttacctaaa accttggtta      725

tcaaatacat ctccagtaca ttccgttctt tttttttttg agacagtctc gctctgtcgc      785

ccaggctgga gtgcagtggc gcaatctcgg ctcactgcaa cctccacctc ccgggttcac      845

gccattctcc tgcctcagcc tcccgagtag ctgggattac gggcgcccgc caccacgccc      905

ggctaatttt ttgtattttt agtagagaca gggtttcacc gtgttagcca ggatggtctc      965

gatctcctga ccttgtgatc cacccacctc ggcctcccaa agtgctggga ttacaggcgt     1025

gagccactgc gcccggccac attcagttct tatcaaagaa ataacccaga cttaatcttg     1085

aatgatacga ttatgcccaa tattaagtaa aaaatataag aaaaggttat cttaaataga     1145

tcttaggcaa aataccagct gatgaaggca tctgatgcct tcatctgttc agtcatctcc     1205

aaaaacagta aaaataacca ctttttgttg ggcaatatga aatttttaaa ggagtagaat     1265

accaaatgat agaaacagac tgcctgaatt gagaattttg atttcttaaa gtgtgtttct     1325

ttctaaattg ctgttcctta atttgattaa tttaattcat gtattatgat taaatctgag     1385

gcagatgagc ttacaagtat tgaaataatt actaattaat cacaaatgtg aagttatgca     1445

tgatgtaaaa aatacaaaca ttctaattaa aggctttgca acaca                     1490


<210>  36
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala 
            100                 105                 110         


Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
        115                 120                 125             


Ala Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln 
    130                 135                 140                 


Gly Cys Gly Val 
145             


<210>  37
<211>  14352
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (56)..(13537)

<400>  37
catttcgcca gctcctctgg gggtgacagg caagtgagac gtgctcagag ctccg atg        58
                                                             Met          
                                                             1            

cca agg cca ggg acc atg gcg ctg tgt ctg ctg acc ttg gtc ctc tcg        106
Pro Arg Pro Gly Thr Met Ala Leu Cys Leu Leu Thr Leu Val Leu Ser           
            5                   10                  15                    

ctc ttg ccc cca caa gct gct gca gaa cag gac ctc agt gtg aac agg        154
Leu Leu Pro Pro Gln Ala Ala Ala Glu Gln Asp Leu Ser Val Asn Arg           
        20                  25                  30                        

gct gtg tgg gat gga gga ggg tgc atc tcc caa ggg gac gtc ttg aac        202
Ala Val Trp Asp Gly Gly Gly Cys Ile Ser Gln Gly Asp Val Leu Asn           
    35                  40                  45                            

cgt cag tgc cag cag ctg tct cag cac gtt agg aca ggt tct gcg gca        250
Arg Gln Cys Gln Gln Leu Ser Gln His Val Arg Thr Gly Ser Ala Ala           
50                  55                  60                  65            

aac acc gcc aca ggt aca aca tct aca aat gtc gtg gag cca aga atg        298
Asn Thr Ala Thr Gly Thr Thr Ser Thr Asn Val Val Glu Pro Arg Met           
                70                  75                  80                

tat ttg agt tgc agc acc aac cct gag atg acc tcg att gag tcc agt        346
Tyr Leu Ser Cys Ser Thr Asn Pro Glu Met Thr Ser Ile Glu Ser Ser           
            85                  90                  95                    

gtg act tca gac act cct ggt gtc tcc agt acc agg atg aca cca aca        394
Val Thr Ser Asp Thr Pro Gly Val Ser Ser Thr Arg Met Thr Pro Thr           
        100                 105                 110                       

gaa tcc aga aca act tca gaa tct acc agt gac agc acc aca ctt ttc        442
Glu Ser Arg Thr Thr Ser Glu Ser Thr Ser Asp Ser Thr Thr Leu Phe           
    115                 120                 125                           

ccc agt tct act gaa gac act tca tct cct aca act cct gaa ggc acc        490
Pro Ser Ser Thr Glu Asp Thr Ser Ser Pro Thr Thr Pro Glu Gly Thr           
130                 135                 140                 145           

gac gtg ccc atg tca aca cca agt gaa gaa agc att tca tca aca atg        538
Asp Val Pro Met Ser Thr Pro Ser Glu Glu Ser Ile Ser Ser Thr Met           
                150                 155                 160               

gct ttt gtc agc act gca cct ctt ccc agt ttt gag gcc tac aca tct        586
Ala Phe Val Ser Thr Ala Pro Leu Pro Ser Phe Glu Ala Tyr Thr Ser           
            165                 170                 175                   

tta aca tat aag gtt gat atg agc aca cct ctg acc act tct act cag        634
Leu Thr Tyr Lys Val Asp Met Ser Thr Pro Leu Thr Thr Ser Thr Gln           
        180                 185                 190                       

gca agt tca tct cct act act cct gaa agc acc acc ata ccc aaa tca        682
Ala Ser Ser Ser Pro Thr Thr Pro Glu Ser Thr Thr Ile Pro Lys Ser           
    195                 200                 205                           

act aac agt gaa gga agc act cca tta aca agt atg cct gcc agc acc        730
Thr Asn Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Ala Ser Thr           
210                 215                 220                 225           

atg aag gtg gcc agt tca gag gct atc acc ctt ttg aca act cct gtt        778
Met Lys Val Ala Ser Ser Glu Ala Ile Thr Leu Leu Thr Thr Pro Val           
                230                 235                 240               

gaa atc agc aca cct gtg acc att tct gct caa gcc agt tca tct cct        826
Glu Ile Ser Thr Pro Val Thr Ile Ser Ala Gln Ala Ser Ser Ser Pro           
            245                 250                 255                   

aca act gct gaa ggt ccc agc ctg tca aac tca gct cct agt gga gga        874
Thr Thr Ala Glu Gly Pro Ser Leu Ser Asn Ser Ala Pro Ser Gly Gly           
        260                 265                 270                       

agc act cca tta aca aga atg cct ctc agc gtg atg ctg gtg gtc agt        922
Ser Thr Pro Leu Thr Arg Met Pro Leu Ser Val Met Leu Val Val Ser           
    275                 280                 285                           

tct gag gct agc acc ctt tca aca act cct gct gcc acc aac att cct        970
Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Ala Ala Thr Asn Ile Pro           
290                 295                 300                 305           

gtg atc act tct act gaa gcc agt tca tct cct aca acg gct gaa ggc       1018
Val Ile Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Glu Gly           
                310                 315                 320               

acc agc ata cca acc tca act tat act gaa gga agc act cca tta aca       1066
Thr Ser Ile Pro Thr Ser Thr Tyr Thr Glu Gly Ser Thr Pro Leu Thr           
            325                 330                 335                   

agt acg cct gcc agc acc atg ccg gtt gcc act tct gaa atg agc aca       1114
Ser Thr Pro Ala Ser Thr Met Pro Val Ala Thr Ser Glu Met Ser Thr           
        340                 345                 350                       

ctt tca ata act cct gtt gac acc agc aca ctt gtg acc act tct act       1162
Leu Ser Ile Thr Pro Val Asp Thr Ser Thr Leu Val Thr Thr Ser Thr           
    355                 360                 365                           

gaa ccc agt tca ctt cct aca act gct gaa gct acc agc atg cta acc       1210
Glu Pro Ser Ser Leu Pro Thr Thr Ala Glu Ala Thr Ser Met Leu Thr           
370                 375                 380                 385           

tca act ctt agt gaa gga agc act cca tta aca aat atg cct gtc agc       1258
Ser Thr Leu Ser Glu Gly Ser Thr Pro Leu Thr Asn Met Pro Val Ser           
                390                 395                 400               

acc ata ttg gtg gcc agt tct gag gct agc acc act tca aca att cct       1306
Thr Ile Leu Val Ala Ser Ser Glu Ala Ser Thr Thr Ser Thr Ile Pro           
            405                 410                 415                   

gtt gac tcc aaa act ttt gtg acc act gct agt gaa gcc agc tca tct       1354
Val Asp Ser Lys Thr Phe Val Thr Thr Ala Ser Glu Ala Ser Ser Ser           
        420                 425                 430                       

ccc aca act gct gaa gat acc agc att gca acc tca act cct agt gaa       1402
Pro Thr Thr Ala Glu Asp Thr Ser Ile Ala Thr Ser Thr Pro Ser Glu           
    435                 440                 445                           

gga agc act cca tta aca agt atg cct gtc agc acc act cca gtg gcc       1450
Gly Ser Thr Pro Leu Thr Ser Met Pro Val Ser Thr Thr Pro Val Ala           
450                 455                 460                 465           

agt tct gag gct agc aac ctt tca aca act cct gtt gac tcc aaa act       1498
Ser Ser Glu Ala Ser Asn Leu Ser Thr Thr Pro Val Asp Ser Lys Thr           
                470                 475                 480               

cag gtg acc act tct act gaa gcc agt tca tct cct cca act gct gaa       1546
Gln Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Pro Thr Ala Glu           
            485                 490                 495                   

gtt aac agc atg cca acc tca act cct agt gaa gga agc act cca tta       1594
Val Asn Ser Met Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu           
        500                 505                 510                       

aca agt atg tct gtc agc acc atg ccg gtg gcc agt tct gag gct agc       1642
Thr Ser Met Ser Val Ser Thr Met Pro Val Ala Ser Ser Glu Ala Ser           
    515                 520                 525                           

acc ctt tca aca act cct gtt gac acc agc aca cct gtg acc act tct       1690
Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser           
530                 535                 540                 545           

agt gaa gcc agt tca tct tct aca act cct gaa ggt acc agc ata cca       1738
Ser Glu Ala Ser Ser Ser Ser Thr Thr Pro Glu Gly Thr Ser Ile Pro           
                550                 555                 560               

acc tca act cct agt gaa gga agc act cca tta aca aac atg cct gtc       1786
Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Asn Met Pro Val           
            565                 570                 575                   

agc acc agg ctg gtg gtc agt tct gag gct agc acc act tca aca act       1834
Ser Thr Arg Leu Val Val Ser Ser Glu Ala Ser Thr Thr Ser Thr Thr           
        580                 585                 590                       

cct gct gac tcc aac act ttt gtg acc act tct agt gaa gct agt tca       1882
Pro Ala Asp Ser Asn Thr Phe Val Thr Thr Ser Ser Glu Ala Ser Ser           
    595                 600                 605                           

tct tct aca act gct gaa ggt acc agc atg cca acc tca act tac agt       1930
Ser Ser Thr Thr Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser           
610                 615                 620                 625           

gaa aga ggc act aca ata aca agt atg tct gtc agc acc aca ctg gtg       1978
Glu Arg Gly Thr Thr Ile Thr Ser Met Ser Val Ser Thr Thr Leu Val           
                630                 635                 640               

gcc agt tct gag gct agc acc ctt tca aca act cct gtt gac tcc aac       2026
Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Ser Asn           
            645                 650                 655                   

act cct gtg acc act tca act gaa gcc act tca tct tct aca act gcg       2074
Thr Pro Val Thr Thr Ser Thr Glu Ala Thr Ser Ser Ser Thr Thr Ala           
        660                 665                 670                       

gaa ggt acc agc atg cca acc tca act tat act gaa gga agc act cca       2122
Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Thr Glu Gly Ser Thr Pro           
    675                 680                 685                           

tta aca agt atg cct gtc aac acc aca ctg gtg gcc agt tct gag gct       2170
Leu Thr Ser Met Pro Val Asn Thr Thr Leu Val Ala Ser Ser Glu Ala           
690                 695                 700                 705           

agc acc ctt tca aca act cct gtt gac acc agc aca cct gtg acc act       2218
Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr           
                710                 715                 720               

tca act gaa gcc agt tcc tct cct aca act gct gat ggt gcc agt atg       2266
Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Asp Gly Ala Ser Met           
            725                 730                 735                   

cca acc tca act cct agt gaa gga agc act cca tta aca agt atg cct       2314
Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Pro           
        740                 745                 750                       

gtc agc aaa acg ctg ttg acc agt tct gag gct agc acc ctt tca aca       2362
Val Ser Lys Thr Leu Leu Thr Ser Ser Glu Ala Ser Thr Leu Ser Thr           
    755                 760                 765                           

act cct ctt gac aca agc aca cat atc acc act tct act gaa gcc agt       2410
Thr Pro Leu Asp Thr Ser Thr His Ile Thr Thr Ser Thr Glu Ala Ser           
770                 775                 780                 785           

tgc tct cct aca acc act gaa ggt acc agc atg cca atc tca act cct       2458
Cys Ser Pro Thr Thr Thr Glu Gly Thr Ser Met Pro Ile Ser Thr Pro           
                790                 795                 800               

agt gaa gga agt cct tta tta aca agt ata cct gtc agc atc aca ccg       2506
Ser Glu Gly Ser Pro Leu Leu Thr Ser Ile Pro Val Ser Ile Thr Pro           
            805                 810                 815                   

gtg acc agt cct gag gct agc acc ctt tca aca act cct gtt gac tcc       2554
Val Thr Ser Pro Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Ser           
        820                 825                 830                       

aac agt cct gtg acc act tct act gaa gtc agt tca tct cct aca cct       2602
Asn Ser Pro Val Thr Thr Ser Thr Glu Val Ser Ser Ser Pro Thr Pro           
    835                 840                 845                           

gct gaa ggt acc agc atg cca acc tca act tat agt gaa gga aga act       2650
Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser Glu Gly Arg Thr           
850                 855                 860                 865           

cct tta aca agt atg cct gtc agc acc aca ctg gtg gcc act tct gca       2698
Pro Leu Thr Ser Met Pro Val Ser Thr Thr Leu Val Ala Thr Ser Ala           
                870                 875                 880               

atc agc acc ctt tca aca act cct gtt gac acc agc aca cct gtg acc       2746
Ile Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr           
            885                 890                 895                   

aat tct act gaa gcc cgt tcg tct cct aca act tct gaa ggt acc agc       2794
Asn Ser Thr Glu Ala Arg Ser Ser Pro Thr Thr Ser Glu Gly Thr Ser           
        900                 905                 910                       

atg cca acc tca act cct ggg gaa gga agc act cca tta aca agt atg       2842
Met Pro Thr Ser Thr Pro Gly Glu Gly Ser Thr Pro Leu Thr Ser Met           
    915                 920                 925                           

cct gac agc acc acg ccg gta gtc agt tct gag gct aga aca ctt tca       2890
Pro Asp Ser Thr Thr Pro Val Val Ser Ser Glu Ala Arg Thr Leu Ser           
930                 935                 940                 945           

gca act cct gtt gac acc agc aca cct gtg acc act tct act gaa gcc       2938
Ala Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser Thr Glu Ala           
                950                 955                 960               

act tca tct cct aca act gct gaa ggt acc agc ata cca acc tcg act       2986
Thr Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Ile Pro Thr Ser Thr           
            965                 970                 975                   

cct agt gaa gga acg act cca tta aca agc aca cct gtc agc cac acg       3034
Pro Ser Glu Gly Thr Thr Pro Leu Thr Ser Thr Pro Val Ser His Thr           
        980                 985                 990                       

ctg gtg gcc aat tct gag gct  agc acc ctt tca aca  act cct gtt gac     3082
Leu Val Ala Asn Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp         
    995                 1000                 1005                         

tcc  aac act cct ttg acc  act tct act gaa gcc  agt tca cct cct        3127
Ser  Asn Thr Pro Leu Thr  Thr Ser Thr Glu Ala  Ser Ser Pro Pro            
1010                 1015                 1020                            

ccc  act gct gaa ggt acc  agc atg cca acc tca  act cct agt gaa        3172
Pro  Thr Ala Glu Gly Thr  Ser Met Pro Thr Ser  Thr Pro Ser Glu            
1025                 1030                 1035                            

gga  agc act cca tta aca  cgt atg cct gtc agc  acc aca atg gtg        3217
Gly  Ser Thr Pro Leu Thr  Arg Met Pro Val Ser  Thr Thr Met Val            
1040                 1045                 1050                            

gcc  agt tct gaa acg agc  aca ctt tca aca act  cct gct gac acc        3262
Ala  Ser Ser Glu Thr Ser  Thr Leu Ser Thr Thr  Pro Ala Asp Thr            
1055                 1060                 1065                            

agc  aca cct gtg acc act  tat tct caa gcc agt  tca tct tct aca        3307
Ser  Thr Pro Val Thr Thr  Tyr Ser Gln Ala Ser  Ser Ser Ser Thr            
1070                 1075                 1080                            

act  gct gac ggt acc agc  atg cca acc tca act  tat agt gaa gga        3352
Thr  Ala Asp Gly Thr Ser  Met Pro Thr Ser Thr  Tyr Ser Glu Gly            
1085                 1090                 1095                            

agc  act cca cta aca agt  gtg cct gtc agc acc  agg ctg gtg gtc        3397
Ser  Thr Pro Leu Thr Ser  Val Pro Val Ser Thr  Arg Leu Val Val            
1100                 1105                 1110                            

agt  tct gag gct agc acc  ctt tcc aca act cct  gtc gac acc agc        3442
Ser  Ser Glu Ala Ser Thr  Leu Ser Thr Thr Pro  Val Asp Thr Ser            
1115                 1120                 1125                            

ata  cct gtc acc act tct  act gaa gcc agt tca  tct cct aca act        3487
Ile  Pro Val Thr Thr Ser  Thr Glu Ala Ser Ser  Ser Pro Thr Thr            
1130                 1135                 1140                            

gct  gaa ggt acc agc ata  cca acc tca cct ccc  agt gaa gga acc        3532
Ala  Glu Gly Thr Ser Ile  Pro Thr Ser Pro Pro  Ser Glu Gly Thr            
1145                 1150                 1155                            

act  ccg tta gca agt atg  cct gtc agc acc acg  ctg gtg gtc agt        3577
Thr  Pro Leu Ala Ser Met  Pro Val Ser Thr Thr  Leu Val Val Ser            
1160                 1165                 1170                            

tct  gag gct aac acc ctt  tca aca act cct gtg  gac tcc aaa act        3622
Ser  Glu Ala Asn Thr Leu  Ser Thr Thr Pro Val  Asp Ser Lys Thr            
1175                 1180                 1185                            

cag  gtg gcc act tct act  gaa gcc agt tca cct  cct cca act gct        3667
Gln  Val Ala Thr Ser Thr  Glu Ala Ser Ser Pro  Pro Pro Thr Ala            
1190                 1195                 1200                            

gaa  gtt acc agc atg cca  acc tca act cct gga  gaa aga agc act        3712
Glu  Val Thr Ser Met Pro  Thr Ser Thr Pro Gly  Glu Arg Ser Thr            
1205                 1210                 1215                            

cca  tta aca agt atg cct  gtc aga cac acg cca  gtg gcc agt tct        3757
Pro  Leu Thr Ser Met Pro  Val Arg His Thr Pro  Val Ala Ser Ser            
1220                 1225                 1230                            

gag  gct agc acc ctt tca  aca tct ccc gtt gac  acc agc aca cct        3802
Glu  Ala Ser Thr Leu Ser  Thr Ser Pro Val Asp  Thr Ser Thr Pro            
1235                 1240                 1245                            

gtg  acc act tct gct gaa  acc agt tcc tct cct  aca acc gct gaa        3847
Val  Thr Thr Ser Ala Glu  Thr Ser Ser Ser Pro  Thr Thr Ala Glu            
1250                 1255                 1260                            

ggt  acc agc ttg cca acc  tca act act agt gaa  gga agt act cta        3892
Gly  Thr Ser Leu Pro Thr  Ser Thr Thr Ser Glu  Gly Ser Thr Leu            
1265                 1270                 1275                            

tta  aca agt ata cct gtc  agc acc acg ctg gtg  acc agt cct gag        3937
Leu  Thr Ser Ile Pro Val  Ser Thr Thr Leu Val  Thr Ser Pro Glu            
1280                 1285                 1290                            

gct  agc acc ctt tta aca  act cct gtt gac act  aaa ggt cct gtg        3982
Ala  Ser Thr Leu Leu Thr  Thr Pro Val Asp Thr  Lys Gly Pro Val            
1295                 1300                 1305                            

gtc  act tct aat gaa gtc  agt tca tct cct aca  cct gct gaa ggt        4027
Val  Thr Ser Asn Glu Val  Ser Ser Ser Pro Thr  Pro Ala Glu Gly            
1310                 1315                 1320                            

acc  agc atg cca acc tca  act tat agt gaa gga  aga act cct tta        4072
Thr  Ser Met Pro Thr Ser  Thr Tyr Ser Glu Gly  Arg Thr Pro Leu            
1325                 1330                 1335                            

aca  agt ata cct gtc aac  acc aca ctg gtg gcc  agt tct gca atc        4117
Thr  Ser Ile Pro Val Asn  Thr Thr Leu Val Ala  Ser Ser Ala Ile            
1340                 1345                 1350                            

agc  atc ctt tca aca act  cct gtt gac aac agc  aca cct gtg acc        4162
Ser  Ile Leu Ser Thr Thr  Pro Val Asp Asn Ser  Thr Pro Val Thr            
1355                 1360                 1365                            

act  tct act gaa gcc tgt  tca tct cct aca act  tct gaa ggt acc        4207
Thr  Ser Thr Glu Ala Cys  Ser Ser Pro Thr Thr  Ser Glu Gly Thr            
1370                 1375                 1380                            

agc  atg cca aac tca aat  cct agt gaa gga acc  act ccg tta aca        4252
Ser  Met Pro Asn Ser Asn  Pro Ser Glu Gly Thr  Thr Pro Leu Thr            
1385                 1390                 1395                            

agt  ata cct gtc agc acc  acg ccg gta gtc agt  tct gag gct agc        4297
Ser  Ile Pro Val Ser Thr  Thr Pro Val Val Ser  Ser Glu Ala Ser            
1400                 1405                 1410                            

acc  ctt tca gca act cct  gtt gac acc agc acc  cct ggg acc act        4342
Thr  Leu Ser Ala Thr Pro  Val Asp Thr Ser Thr  Pro Gly Thr Thr            
1415                 1420                 1425                            

tct  gct gaa gcc act tca  tct cct aca act gct  gaa ggt atc agc        4387
Ser  Ala Glu Ala Thr Ser  Ser Pro Thr Thr Ala  Glu Gly Ile Ser            
1430                 1435                 1440                            

ata  cca acc tca act cct  agt gaa gga aag act  cca tta aaa agt        4432
Ile  Pro Thr Ser Thr Pro  Ser Glu Gly Lys Thr  Pro Leu Lys Ser            
1445                 1450                 1455                            

ata  cct gtc agc aac acg  ccg gtg gcc aat tct  gag gct agc acc        4477
Ile  Pro Val Ser Asn Thr  Pro Val Ala Asn Ser  Glu Ala Ser Thr            
1460                 1465                 1470                            

ctt  tca aca act cct gtt  gac tct aac agt cct  gtg gtc act tct        4522
Leu  Ser Thr Thr Pro Val  Asp Ser Asn Ser Pro  Val Val Thr Ser            
1475                 1480                 1485                            

aca  gca gtc agt tca tct  cct aca cct gct gaa  ggt acc agc ata        4567
Thr  Ala Val Ser Ser Ser  Pro Thr Pro Ala Glu  Gly Thr Ser Ile            
1490                 1495                 1500                            

gca  atc tca acg cct agt  gaa gga agc act gca  tta aca agt ata        4612
Ala  Ile Ser Thr Pro Ser  Glu Gly Ser Thr Ala  Leu Thr Ser Ile            
1505                 1510                 1515                            

cct  gtc agc acc aca aca  gtg gcc agt tct gaa  atc aac agc ctt        4657
Pro  Val Ser Thr Thr Thr  Val Ala Ser Ser Glu  Ile Asn Ser Leu            
1520                 1525                 1530                            

tca  aca act cct gct gtc  acc agc aca cct gtg  acc act tat tct        4702
Ser  Thr Thr Pro Ala Val  Thr Ser Thr Pro Val  Thr Thr Tyr Ser            
1535                 1540                 1545                            

caa  gcc agt tca tct cct  aca act gct gac ggt  acc agc atg caa        4747
Gln  Ala Ser Ser Ser Pro  Thr Thr Ala Asp Gly  Thr Ser Met Gln            
1550                 1555                 1560                            

acc  tca act tat agt gaa  gga agc act cca cta  aca agt ttg cct        4792
Thr  Ser Thr Tyr Ser Glu  Gly Ser Thr Pro Leu  Thr Ser Leu Pro            
1565                 1570                 1575                            

gtc  agc acc atg ctg gtg  gtc agt tct gag gct  aac acc ctt tca        4837
Val  Ser Thr Met Leu Val  Val Ser Ser Glu Ala  Asn Thr Leu Ser            
1580                 1585                 1590                            

aca  acc cct att gac tcc  aaa act cag gtg acc  gct tct act gaa        4882
Thr  Thr Pro Ile Asp Ser  Lys Thr Gln Val Thr  Ala Ser Thr Glu            
1595                 1600                 1605                            

gcc  agt tca tct aca acc  gct gaa ggt agc agc  atg aca atc tca        4927
Ala  Ser Ser Ser Thr Thr  Ala Glu Gly Ser Ser  Met Thr Ile Ser            
1610                 1615                 1620                            

act  cct agt gaa gga agt  cct cta tta aca agt  ata cct gtc agc        4972
Thr  Pro Ser Glu Gly Ser  Pro Leu Leu Thr Ser  Ile Pro Val Ser            
1625                 1630                 1635                            

acc  acg ccg gtg gcc agt  cct gag gct agc acc  ctt tca aca act        5017
Thr  Thr Pro Val Ala Ser  Pro Glu Ala Ser Thr  Leu Ser Thr Thr            
1640                 1645                 1650                            

cct  gtt gac tcc aac agt  cct gtg atc act tct  act gaa gtc agt        5062
Pro  Val Asp Ser Asn Ser  Pro Val Ile Thr Ser  Thr Glu Val Ser            
1655                 1660                 1665                            

tca  tct cct aca cct gct  gaa ggt acc agc atg  cca acc tca act        5107
Ser  Ser Pro Thr Pro Ala  Glu Gly Thr Ser Met  Pro Thr Ser Thr            
1670                 1675                 1680                            

tat  act gaa gga aga act  cct tta aca agt ata  act gtc aga aca        5152
Tyr  Thr Glu Gly Arg Thr  Pro Leu Thr Ser Ile  Thr Val Arg Thr            
1685                 1690                 1695                            

aca  ccg gtg gcc agc tct  gca atc agc acc ctt  tca aca act ccc        5197
Thr  Pro Val Ala Ser Ser  Ala Ile Ser Thr Leu  Ser Thr Thr Pro            
1700                 1705                 1710                            

gtt  gac aac agc aca cct  gtg acc act tct act  gaa gcc cgt tca        5242
Val  Asp Asn Ser Thr Pro  Val Thr Thr Ser Thr  Glu Ala Arg Ser            
1715                 1720                 1725                            

tct  cct aca act tct gaa  ggt acc agc atg cca  aac tca act cct        5287
Ser  Pro Thr Thr Ser Glu  Gly Thr Ser Met Pro  Asn Ser Thr Pro            
1730                 1735                 1740                            

agt  gaa gga acc act cca  tta aca agt ata cct  gtc agc acc acg        5332
Ser  Glu Gly Thr Thr Pro  Leu Thr Ser Ile Pro  Val Ser Thr Thr            
1745                 1750                 1755                            

ccg  gta ctc agt tct gag  gct agc acc ctt tca  gca act cct att        5377
Pro  Val Leu Ser Ser Glu  Ala Ser Thr Leu Ser  Ala Thr Pro Ile            
1760                 1765                 1770                            

gac  acc agc acc cct gtg  acc act tct act gaa  gcc act tcg tct        5422
Asp  Thr Ser Thr Pro Val  Thr Thr Ser Thr Glu  Ala Thr Ser Ser            
1775                 1780                 1785                            

cct  aca act gct gaa ggt  acc agc ata cca acc  tcg act ctt agt        5467
Pro  Thr Thr Ala Glu Gly  Thr Ser Ile Pro Thr  Ser Thr Leu Ser            
1790                 1795                 1800                            

gaa  gga atg act cca tta  aca agc aca cct gtc  agc cac acg ctg        5512
Glu  Gly Met Thr Pro Leu  Thr Ser Thr Pro Val  Ser His Thr Leu            
1805                 1810                 1815                            

gtg  gcc aat tct gag gct  agc acc ctt tca aca  act cct gtt gac        5557
Val  Ala Asn Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp            
1820                 1825                 1830                            

tct  aac agt cct gtg gtc  act tct aca gca gtc  agt tca tct cct        5602
Ser  Asn Ser Pro Val Val  Thr Ser Thr Ala Val  Ser Ser Ser Pro            
1835                 1840                 1845                            

aca  cct gct gaa ggt acc  agc ata gca acc tca  acg cct agt gaa        5647
Thr  Pro Ala Glu Gly Thr  Ser Ile Ala Thr Ser  Thr Pro Ser Glu            
1850                 1855                 1860                            

gga  agc act gca tta aca  agt ata cct gtc agc  acc aca aca gtg        5692
Gly  Ser Thr Ala Leu Thr  Ser Ile Pro Val Ser  Thr Thr Thr Val            
1865                 1870                 1875                            

gcc  agt tct gaa acc aac  acc ctt tca aca act  ccc gct gtc acc        5737
Ala  Ser Ser Glu Thr Asn  Thr Leu Ser Thr Thr  Pro Ala Val Thr            
1880                 1885                 1890                            

agc  aca cct gtg acc act  tat gct caa gtc agt  tca tct cct aca        5782
Ser  Thr Pro Val Thr Thr  Tyr Ala Gln Val Ser  Ser Ser Pro Thr            
1895                 1900                 1905                            

act  gct gac ggt agc agc  atg cca acc tca act  cct agg gaa gga        5827
Thr  Ala Asp Gly Ser Ser  Met Pro Thr Ser Thr  Pro Arg Glu Gly            
1910                 1915                 1920                            

agg  cct cca tta aca agt  ata cct gtc agc acc  aca aca gtg gcc        5872
Arg  Pro Pro Leu Thr Ser  Ile Pro Val Ser Thr  Thr Thr Val Ala            
1925                 1930                 1935                            

agt  tct gaa atc aac acc  ctt tca aca act ctt  gct gac acc agg        5917
Ser  Ser Glu Ile Asn Thr  Leu Ser Thr Thr Leu  Ala Asp Thr Arg            
1940                 1945                 1950                            

aca  cct gtg acc act tat  tct caa gcc agt tca  tct cct aca act        5962
Thr  Pro Val Thr Thr Tyr  Ser Gln Ala Ser Ser  Ser Pro Thr Thr            
1955                 1960                 1965                            

gct  gat ggt acc agc atg  cca acc cca gct tat  agt gaa gga agc        6007
Ala  Asp Gly Thr Ser Met  Pro Thr Pro Ala Tyr  Ser Glu Gly Ser            
1970                 1975                 1980                            

act  cca cta aca agt atg  cct ctc agc acc acg  ctg gtg gtc agt        6052
Thr  Pro Leu Thr Ser Met  Pro Leu Ser Thr Thr  Leu Val Val Ser            
1985                 1990                 1995                            

tct  gag gct agc act ctt  tcc aca act cct gtt  gac acc agc act        6097
Ser  Glu Ala Ser Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser Thr            
2000                 2005                 2010                            

cct  gcc acc act tct act  gaa ggc agt tca tct  cct aca act gca        6142
Pro  Ala Thr Thr Ser Thr  Glu Gly Ser Ser Ser  Pro Thr Thr Ala            
2015                 2020                 2025                            

gga  ggt acc agc ata caa  acc tca act cct agt  gaa cgg acc act        6187
Gly  Gly Thr Ser Ile Gln  Thr Ser Thr Pro Ser  Glu Arg Thr Thr            
2030                 2035                 2040                            

cca  tta gca ggt atg cct  gtc agc act acg ctt  gtg gtc agt tct        6232
Pro  Leu Ala Gly Met Pro  Val Ser Thr Thr Leu  Val Val Ser Ser            
2045                 2050                 2055                            

gag  ggt aac acc ctt tca  aca act cct gtt gac  tcc aaa act cag        6277
Glu  Gly Asn Thr Leu Ser  Thr Thr Pro Val Asp  Ser Lys Thr Gln            
2060                 2065                 2070                            

gtg  acc aat tct act gaa  gcc agt tca tct gca  acc gct gaa ggt        6322
Val  Thr Asn Ser Thr Glu  Ala Ser Ser Ser Ala  Thr Ala Glu Gly            
2075                 2080                 2085                            

agc  agc atg aca atc tca  gct cct agt gaa gga  agt cct cta cta        6367
Ser  Ser Met Thr Ile Ser  Ala Pro Ser Glu Gly  Ser Pro Leu Leu            
2090                 2095                 2100                            

aca  agt ata cct ctc agc  acc acg ccg gtg gcc  agt cct gag gct        6412
Thr  Ser Ile Pro Leu Ser  Thr Thr Pro Val Ala  Ser Pro Glu Ala            
2105                 2110                 2115                            

agc  acc ctt tca aca act  cct gtt gac tcc aac  agt cct gtg atc        6457
Ser  Thr Leu Ser Thr Thr  Pro Val Asp Ser Asn  Ser Pro Val Ile            
2120                 2125                 2130                            

act  tct act gaa gtc agt  tca tct cct ata cct  act gaa ggt acc        6502
Thr  Ser Thr Glu Val Ser  Ser Ser Pro Ile Pro  Thr Glu Gly Thr            
2135                 2140                 2145                            

agc  atg caa acc tca act  tat agt gac aga aga  act cct tta aca        6547
Ser  Met Gln Thr Ser Thr  Tyr Ser Asp Arg Arg  Thr Pro Leu Thr            
2150                 2155                 2160                            

agt  atg cct gtc agc acc  aca gtg gtg gcc agt  tct gca atc agc        6592
Ser  Met Pro Val Ser Thr  Thr Val Val Ala Ser  Ser Ala Ile Ser            
2165                 2170                 2175                            

acc  ctt tca aca act cct  gtt gac acc agc aca  cct gtg acc aat        6637
Thr  Leu Ser Thr Thr Pro  Val Asp Thr Ser Thr  Pro Val Thr Asn            
2180                 2185                 2190                            

tct  act gaa gcc cgt tca  tct cct aca act tct  gaa ggt acc agc        6682
Ser  Thr Glu Ala Arg Ser  Ser Pro Thr Thr Ser  Glu Gly Thr Ser            
2195                 2200                 2205                            

atg  cca acc tca act cct  agt gaa gga agc act  cca ttc aca agt        6727
Met  Pro Thr Ser Thr Pro  Ser Glu Gly Ser Thr  Pro Phe Thr Ser            
2210                 2215                 2220                            

atg  cct gtc agc acc atg  ccg gta gtt act tct  gag gct agc acc        6772
Met  Pro Val Ser Thr Met  Pro Val Val Thr Ser  Glu Ala Ser Thr            
2225                 2230                 2235                            

ctt  tca gca act cct gtt  gac acc agc aca cct  gtg acc act tct        6817
Leu  Ser Ala Thr Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr Ser            
2240                 2245                 2250                            

act  gaa gcc act tca tct  cct aca act gct gaa  ggt acc agc ata        6862
Thr  Glu Ala Thr Ser Ser  Pro Thr Thr Ala Glu  Gly Thr Ser Ile            
2255                 2260                 2265                            

cca  act tca act ctt agt  gaa gga acg act cca  tta aca agt ata        6907
Pro  Thr Ser Thr Leu Ser  Glu Gly Thr Thr Pro  Leu Thr Ser Ile            
2270                 2275                 2280                            

cct  gtc agc cac acg ctg  gtg gcc aat tct gag  gtt agc acc ctt        6952
Pro  Val Ser His Thr Leu  Val Ala Asn Ser Glu  Val Ser Thr Leu            
2285                 2290                 2295                            

tca  aca act cct gtt gac  tcc aac act cct ttc  act act tct act        6997
Ser  Thr Thr Pro Val Asp  Ser Asn Thr Pro Phe  Thr Thr Ser Thr            
2300                 2305                 2310                            

gaa  gcc agt tca cct cct  ccc act gct gaa ggt  acc agc atg cca        7042
Glu  Ala Ser Ser Pro Pro  Pro Thr Ala Glu Gly  Thr Ser Met Pro            
2315                 2320                 2325                            

acc  tca act tct agt gaa  gga aac act cca tta  aca cgt atg cct        7087
Thr  Ser Thr Ser Ser Glu  Gly Asn Thr Pro Leu  Thr Arg Met Pro            
2330                 2335                 2340                            

gtc  agc acc aca atg gtg  gcc agt ttt gaa aca  agc aca ctt tct        7132
Val  Ser Thr Thr Met Val  Ala Ser Phe Glu Thr  Ser Thr Leu Ser            
2345                 2350                 2355                            

aca  act cct gct gac acc  agc aca cct gtg act  act tat tct caa        7177
Thr  Thr Pro Ala Asp Thr  Ser Thr Pro Val Thr  Thr Tyr Ser Gln            
2360                 2365                 2370                            

gcc  ggt tca tct cct aca  act gct gac gat act  agc atg cca acc        7222
Ala  Gly Ser Ser Pro Thr  Thr Ala Asp Asp Thr  Ser Met Pro Thr            
2375                 2380                 2385                            

tca  act tat agt gaa gga  agc act cca cta aca  agt gtg cct gtc        7267
Ser  Thr Tyr Ser Glu Gly  Ser Thr Pro Leu Thr  Ser Val Pro Val            
2390                 2395                 2400                            

agc  acc atg ccg gtg gtc  agt tct gag gct agc  acc cat tcc aca        7312
Ser  Thr Met Pro Val Val  Ser Ser Glu Ala Ser  Thr His Ser Thr            
2405                 2410                 2415                            

act  cct gtt gac acc agc  aca cct gtc acc act  tct act gaa gcc        7357
Thr  Pro Val Asp Thr Ser  Thr Pro Val Thr Thr  Ser Thr Glu Ala            
2420                 2425                 2430                            

agt  tca tct cct aca act  gct gaa ggt acc agc  ata cca acc tca        7402
Ser  Ser Ser Pro Thr Thr  Ala Glu Gly Thr Ser  Ile Pro Thr Ser            
2435                 2440                 2445                            

cct  cct agt gaa gga acc  act ccg tta gca agt  atg cct gtc agc        7447
Pro  Pro Ser Glu Gly Thr  Thr Pro Leu Ala Ser  Met Pro Val Ser            
2450                 2455                 2460                            

acc  acg ccg gtg gtc agt  tct gag gct ggc acc  ctt tcc aca act        7492
Thr  Thr Pro Val Val Ser  Ser Glu Ala Gly Thr  Leu Ser Thr Thr            
2465                 2470                 2475                            

cct  gtt gac acc agc aca  cct atg acc act tct  act gaa gcc agt        7537
Pro  Val Asp Thr Ser Thr  Pro Met Thr Thr Ser  Thr Glu Ala Ser            
2480                 2485                 2490                            

tca  tct cct aca act gct  gaa gat atc gtc gtg  cca atc tca act        7582
Ser  Ser Pro Thr Thr Ala  Glu Asp Ile Val Val  Pro Ile Ser Thr            
2495                 2500                 2505                            

gct  agt gaa gga agt act  cta tta aca agt ata  cct gtc agc acc        7627
Ala  Ser Glu Gly Ser Thr  Leu Leu Thr Ser Ile  Pro Val Ser Thr            
2510                 2515                 2520                            

acg  cca gtg gcc agt cct  gag gct agc acc ctt  tca aca act cct        7672
Thr  Pro Val Ala Ser Pro  Glu Ala Ser Thr Leu  Ser Thr Thr Pro            
2525                 2530                 2535                            

gtt  gac tcc aac agt cct  gtg gtc act tct act  gaa atc agt tca        7717
Val  Asp Ser Asn Ser Pro  Val Val Thr Ser Thr  Glu Ile Ser Ser            
2540                 2545                 2550                            

tct  gct aca tcc gct gaa  ggt acc agc atg cct  acc tca act tat        7762
Ser  Ala Thr Ser Ala Glu  Gly Thr Ser Met Pro  Thr Ser Thr Tyr            
2555                 2560                 2565                            

agt  gaa gga agc act cca  tta aga agt atg cct  gtc agc acc aag        7807
Ser  Glu Gly Ser Thr Pro  Leu Arg Ser Met Pro  Val Ser Thr Lys            
2570                 2575                 2580                            

ccg  ttg gcc agt tct gag  gct agc act ctt tca  aca act cct gtt        7852
Pro  Leu Ala Ser Ser Glu  Ala Ser Thr Leu Ser  Thr Thr Pro Val            
2585                 2590                 2595                            

gac  acc agc ata cct gtc  acc act tct act gaa  acc agt tca tct        7897
Asp  Thr Ser Ile Pro Val  Thr Thr Ser Thr Glu  Thr Ser Ser Ser            
2600                 2605                 2610                            

cct  aca act gca aaa gat  acc agc atg cca atc  tca act cct agt        7942
Pro  Thr Thr Ala Lys Asp  Thr Ser Met Pro Ile  Ser Thr Pro Ser            
2615                 2620                 2625                            

gaa  gta agt act tca tta  aca agt ata ctt gtc  agc acc atg cca        7987
Glu  Val Ser Thr Ser Leu  Thr Ser Ile Leu Val  Ser Thr Met Pro            
2630                 2635                 2640                            

gtg  gcc agt tct gag gct  agc acc ctt tca aca  act cct gtt gac        8032
Val  Ala Ser Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp            
2645                 2650                 2655                            

acc  agg aca ctt gtg acc  act tcc act gga acc  agt tca tct cct        8077
Thr  Arg Thr Leu Val Thr  Thr Ser Thr Gly Thr  Ser Ser Ser Pro            
2660                 2665                 2670                            

aca  act gct gaa ggt agc  agc atg cca acc tca  act cct ggt gaa        8122
Thr  Thr Ala Glu Gly Ser  Ser Met Pro Thr Ser  Thr Pro Gly Glu            
2675                 2680                 2685                            

aga  agc act cca tta aca  aat ata ctt gtc agc  acc acg ctg ttg        8167
Arg  Ser Thr Pro Leu Thr  Asn Ile Leu Val Ser  Thr Thr Leu Leu            
2690                 2695                 2700                            

gcc  aat tct gag gct agc  acc ctt tca aca act  cct gtt gac acc        8212
Ala  Asn Ser Glu Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp Thr            
2705                 2710                 2715                            

agc  aca cct gtc acc act  tct gct gaa gcc agt  tct tct cct aca        8257
Ser  Thr Pro Val Thr Thr  Ser Ala Glu Ala Ser  Ser Ser Pro Thr            
2720                 2725                 2730                            

act  gct gaa ggt acc agc  atg cga atc tca act  cct agt gat gga        8302
Thr  Ala Glu Gly Thr Ser  Met Arg Ile Ser Thr  Pro Ser Asp Gly            
2735                 2740                 2745                            

agt  act cca tta aca agt  ata ctt gtc agc acc  ctg cca gtg gcc        8347
Ser  Thr Pro Leu Thr Ser  Ile Leu Val Ser Thr  Leu Pro Val Ala            
2750                 2755                 2760                            

agt  tct gag gct agc acc  gtt tca aca act gct  gtt gac acc agc        8392
Ser  Ser Glu Ala Ser Thr  Val Ser Thr Thr Ala  Val Asp Thr Ser            
2765                 2770                 2775                            

ata  cct gtc acc act tct  act gaa gcc agt tcc  tct cct aca act        8437
Ile  Pro Val Thr Thr Ser  Thr Glu Ala Ser Ser  Ser Pro Thr Thr            
2780                 2785                 2790                            

gct  gaa gtt acc agc atg  cca acc tca act cct  agt gaa aca agt        8482
Ala  Glu Val Thr Ser Met  Pro Thr Ser Thr Pro  Ser Glu Thr Ser            
2795                 2800                 2805                            

act  cca tta act agt atg  cct gtc aac cac acg  cca gtg gcc agt        8527
Thr  Pro Leu Thr Ser Met  Pro Val Asn His Thr  Pro Val Ala Ser            
2810                 2815                 2820                            

tct  gag gct ggc acc ctt  tca aca act cct gtt  gac acc agc aca        8572
Ser  Glu Ala Gly Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser Thr            
2825                 2830                 2835                            

cct  gtg acc act tct act  aaa gcc agt tca tct  cct aca act gct        8617
Pro  Val Thr Thr Ser Thr  Lys Ala Ser Ser Ser  Pro Thr Thr Ala            
2840                 2845                 2850                            

gaa  ggt atc gtc gtg cca  atc tca act gct agt  gaa gga agt act        8662
Glu  Gly Ile Val Val Pro  Ile Ser Thr Ala Ser  Glu Gly Ser Thr            
2855                 2860                 2865                            

cta  tta aca agt ata cct  gtc agc acc acg ccg  gtg gcc agt tct        8707
Leu  Leu Thr Ser Ile Pro  Val Ser Thr Thr Pro  Val Ala Ser Ser            
2870                 2875                 2880                            

gag  gct agc acc ctt tca  aca act cct gtt gat  acc agc ata cct        8752
Glu  Ala Ser Thr Leu Ser  Thr Thr Pro Val Asp  Thr Ser Ile Pro            
2885                 2890                 2895                            

gtc  acc act tct act gaa  ggc agt tct tct cct  aca act gct gaa        8797
Val  Thr Thr Ser Thr Glu  Gly Ser Ser Ser Pro  Thr Thr Ala Glu            
2900                 2905                 2910                            

ggt  acc agc atg cca atc  tca act cct agt gaa  gta agt act cca        8842
Gly  Thr Ser Met Pro Ile  Ser Thr Pro Ser Glu  Val Ser Thr Pro            
2915                 2920                 2925                            

tta  aca agt ata ctt gtc  agc acc gtg cca gtg  gcc ggt tct gag        8887
Leu  Thr Ser Ile Leu Val  Ser Thr Val Pro Val  Ala Gly Ser Glu            
2930                 2935                 2940                            

gct  agc acc ctt tca aca  act cct gtt gac acc  agg aca cct gtc        8932
Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp Thr  Arg Thr Pro Val            
2945                 2950                 2955                            

acc  act tct gct gaa gct  agt tct tct cct aca  act gct gaa ggt        8977
Thr  Thr Ser Ala Glu Ala  Ser Ser Ser Pro Thr  Thr Ala Glu Gly            
2960                 2965                 2970                            

acc  agc atg cca atc tca  act cct ggc gaa aga  aga act cca tta        9022
Thr  Ser Met Pro Ile Ser  Thr Pro Gly Glu Arg  Arg Thr Pro Leu            
2975                 2980                 2985                            

aca  agt atg tct gtc agc  acc atg ccg gtg gcc  agt tct gag gct        9067
Thr  Ser Met Ser Val Ser  Thr Met Pro Val Ala  Ser Ser Glu Ala            
2990                 2995                 3000                            

agc  acc ctt tca aga act  cct gct gac acc agc  aca cct gtg acc        9112
Ser  Thr Leu Ser Arg Thr  Pro Ala Asp Thr Ser  Thr Pro Val Thr            
3005                 3010                 3015                            

act  tct act gaa gcc agt  tcc tct cct aca act  gct gaa ggt acc        9157
Thr  Ser Thr Glu Ala Ser  Ser Ser Pro Thr Thr  Ala Glu Gly Thr            
3020                 3025                 3030                            

ggc  ata cca atc tca act  cct agt gaa gga agt  act cca tta aca        9202
Gly  Ile Pro Ile Ser Thr  Pro Ser Glu Gly Ser  Thr Pro Leu Thr            
3035                 3040                 3045                            

agt  ata cct gtc agc acc  acg cca gtg gcc att  cct gag gct agc        9247
Ser  Ile Pro Val Ser Thr  Thr Pro Val Ala Ile  Pro Glu Ala Ser            
3050                 3055                 3060                            

acc  ctt tca aca act cct  gtt gac tcc aac agt  cct gtg gtc act        9292
Thr  Leu Ser Thr Thr Pro  Val Asp Ser Asn Ser  Pro Val Val Thr            
3065                 3070                 3075                            

tct  act gaa gtc agt tca  tct cct aca cct gct  gaa ggt acc agc        9337
Ser  Thr Glu Val Ser Ser  Ser Pro Thr Pro Ala  Glu Gly Thr Ser            
3080                 3085                 3090                            

atg  cca atc tca act tat  agt gaa gga agc act  cca tta aca ggt        9382
Met  Pro Ile Ser Thr Tyr  Ser Glu Gly Ser Thr  Pro Leu Thr Gly            
3095                 3100                 3105                            

gtg  cct gtc agc acc aca  ccg gtg acc agt tct  gca atc agc acc        9427
Val  Pro Val Ser Thr Thr  Pro Val Thr Ser Ser  Ala Ile Ser Thr            
3110                 3115                 3120                            

ctt  tca aca act cct gtt  gac acc agc aca cct  gtg acc act tct        9472
Leu  Ser Thr Thr Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr Ser            
3125                 3130                 3135                            

act  gaa gcc cat tca tct  cct aca act tct gaa  ggt acc agc atg        9517
Thr  Glu Ala His Ser Ser  Pro Thr Thr Ser Glu  Gly Thr Ser Met            
3140                 3145                 3150                            

cca  acc tca act cct agt  gaa gga agt act cca  tta aca tat atg        9562
Pro  Thr Ser Thr Pro Ser  Glu Gly Ser Thr Pro  Leu Thr Tyr Met            
3155                 3160                 3165                            

cct  gtc agc acc atg ctg  gta gtc agt tct gag  gat agc acc ctt        9607
Pro  Val Ser Thr Met Leu  Val Val Ser Ser Glu  Asp Ser Thr Leu            
3170                 3175                 3180                            

tca  gca act cct gtt gac  acc agc aca cct gtg  acc act tct act        9652
Ser  Ala Thr Pro Val Asp  Thr Ser Thr Pro Val  Thr Thr Ser Thr            
3185                 3190                 3195                            

gaa  gcc act tca tct aca  act gct gaa ggt acc  agc att cca acc        9697
Glu  Ala Thr Ser Ser Thr  Thr Ala Glu Gly Thr  Ser Ile Pro Thr            
3200                 3205                 3210                            

tca  act cct agt gaa gga  atg act cca tta act  agt gta cct gtc        9742
Ser  Thr Pro Ser Glu Gly  Met Thr Pro Leu Thr  Ser Val Pro Val            
3215                 3220                 3225                            

agc  aac acg ccg gtg gcc  agt tct gag gct agc  atc ctt tca aca        9787
Ser  Asn Thr Pro Val Ala  Ser Ser Glu Ala Ser  Ile Leu Ser Thr            
3230                 3235                 3240                            

act  cct gtt gac tcc aac  act cct ttg acc act  tct act gaa gcc        9832
Thr  Pro Val Asp Ser Asn  Thr Pro Leu Thr Thr  Ser Thr Glu Ala            
3245                 3250                 3255                            

agt  tca tct cct ccc act  gct gaa ggt acc agc  atg cca acc tca        9877
Ser  Ser Ser Pro Pro Thr  Ala Glu Gly Thr Ser  Met Pro Thr Ser            
3260                 3265                 3270                            

act  cct agt gaa gga agc  act cca tta aca agt  atg cct gtc agc        9922
Thr  Pro Ser Glu Gly Ser  Thr Pro Leu Thr Ser  Met Pro Val Ser            
3275                 3280                 3285                            

acc  aca acg gtg gcc agt  tct gaa acg agc acc  ctt tca aca act        9967
Thr  Thr Thr Val Ala Ser  Ser Glu Thr Ser Thr  Leu Ser Thr Thr            
3290                 3295                 3300                            

cct  gct gac acc agc aca  cct gtg acc act tat  tct caa gcc agt       10012
Pro  Ala Asp Thr Ser Thr  Pro Val Thr Thr Tyr  Ser Gln Ala Ser            
3305                 3310                 3315                            

tca  tct cct cca att gct  gac ggt act agc atg  cca acc tca act       10057
Ser  Ser Pro Pro Ile Ala  Asp Gly Thr Ser Met  Pro Thr Ser Thr            
3320                 3325                 3330                            

tat  agt gaa gga agc act  cca cta aca aat atg  tct ttc agc acc       10102
Tyr  Ser Glu Gly Ser Thr  Pro Leu Thr Asn Met  Ser Phe Ser Thr            
3335                 3340                 3345                            

acg  cca gtg gtc agt tct  gag gct agc acc ctt  tcc aca act cct       10147
Thr  Pro Val Val Ser Ser  Glu Ala Ser Thr Leu  Ser Thr Thr Pro            
3350                 3355                 3360                            

gtt  gac acc agc aca cct  gtc acc act tct act  gaa gcc agt tta       10192
Val  Asp Thr Ser Thr Pro  Val Thr Thr Ser Thr  Glu Ala Ser Leu            
3365                 3370                 3375                            

tct  cct aca act gct gaa  ggt acc agc ata cca  acc tca agt cct       10237
Ser  Pro Thr Thr Ala Glu  Gly Thr Ser Ile Pro  Thr Ser Ser Pro            
3380                 3385                 3390                            

agt  gaa gga acc act cca  tta gca agt atg cct  gtc agc acc acg       10282
Ser  Glu Gly Thr Thr Pro  Leu Ala Ser Met Pro  Val Ser Thr Thr            
3395                 3400                 3405                            

ccg  gtg gtc agt tct gag  gtt aac acc ctt tca  aca act cct gtg       10327
Pro  Val Val Ser Ser Glu  Val Asn Thr Leu Ser  Thr Thr Pro Val            
3410                 3415                 3420                            

gac  tcc aac act ctg gtg  acc act tct act gaa  gcc agt tca tct       10372
Asp  Ser Asn Thr Leu Val  Thr Thr Ser Thr Glu  Ala Ser Ser Ser            
3425                 3430                 3435                            

cct  aca atc gct gaa ggt  acc agc ttg cca acc  tca act act agt       10417
Pro  Thr Ile Ala Glu Gly  Thr Ser Leu Pro Thr  Ser Thr Thr Ser            
3440                 3445                 3450                            

gaa  gga agc act cca tta  tca att atg cct ctc  agt acc acg ccg       10462
Glu  Gly Ser Thr Pro Leu  Ser Ile Met Pro Leu  Ser Thr Thr Pro            
3455                 3460                 3465                            

gtg  gcc agt tct gag gct  agc acc ctt tca aca  act cct gtt gac       10507
Val  Ala Ser Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp            
3470                 3475                 3480                            

acc  agc aca cct gtg acc  act tct tct cca acc  aat tca tct cct       10552
Thr  Ser Thr Pro Val Thr  Thr Ser Ser Pro Thr  Asn Ser Ser Pro            
3485                 3490                 3495                            

aca  act gct gaa gtt acc  agc atg cca aca tca  act gct ggt gaa       10597
Thr  Thr Ala Glu Val Thr  Ser Met Pro Thr Ser  Thr Ala Gly Glu            
3500                 3505                 3510                            

gga  agc act cca tta aca  aat atg cct gtc agc  acc aca ccg gtg       10642
Gly  Ser Thr Pro Leu Thr  Asn Met Pro Val Ser  Thr Thr Pro Val            
3515                 3520                 3525                            

gcc  agt tct gag gct agc  acc ctt tca aca act  cct gtt gac tcc       10687
Ala  Ser Ser Glu Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp Ser            
3530                 3535                 3540                            

aac  act ttt gtt acc agt  tct agt caa gcc agt  tca tct cca gca       10732
Asn  Thr Phe Val Thr Ser  Ser Ser Gln Ala Ser  Ser Ser Pro Ala            
3545                 3550                 3555                            

act  ctt cag gtc acc act  atg cgt atg tct act  cca agt gaa gga       10777
Thr  Leu Gln Val Thr Thr  Met Arg Met Ser Thr  Pro Ser Glu Gly            
3560                 3565                 3570                            

agc  tct tca tta aca act  atg ctc ctc agc agc  aca tat gtg acc       10822
Ser  Ser Ser Leu Thr Thr  Met Leu Leu Ser Ser  Thr Tyr Val Thr            
3575                 3580                 3585                            

agt  tct gag gct agc aca  cct tcc act cct tct  gtt gac aga agc       10867
Ser  Ser Glu Ala Ser Thr  Pro Ser Thr Pro Ser  Val Asp Arg Ser            
3590                 3595                 3600                            

aca  cct gtg acc act tct  act cag agc aat tct  act cct aca cct       10912
Thr  Pro Val Thr Thr Ser  Thr Gln Ser Asn Ser  Thr Pro Thr Pro            
3605                 3610                 3615                            

cct  gaa gtt atc acc ctg  cca atg tca act cct  agt gaa gta agc       10957
Pro  Glu Val Ile Thr Leu  Pro Met Ser Thr Pro  Ser Glu Val Ser            
3620                 3625                 3630                            

act  cca tta acc att atg  cct gtc agc acc aca  tcg gtg acc att       11002
Thr  Pro Leu Thr Ile Met  Pro Val Ser Thr Thr  Ser Val Thr Ile            
3635                 3640                 3645                            

tct  gag gct ggc aca gct  tca aca ctt cct gtt  gac acc agc aca       11047
Ser  Glu Ala Gly Thr Ala  Ser Thr Leu Pro Val  Asp Thr Ser Thr            
3650                 3655                 3660                            

cct  gtg atc act tct acc  caa gtc agt tca tct  cct gtg act cct       11092
Pro  Val Ile Thr Ser Thr  Gln Val Ser Ser Ser  Pro Val Thr Pro            
3665                 3670                 3675                            

gaa  ggt acc acc atg cca  atc tgg acg cct agt  gaa gga agc act       11137
Glu  Gly Thr Thr Met Pro  Ile Trp Thr Pro Ser  Glu Gly Ser Thr            
3680                 3685                 3690                            

cca  tta aca act atg cct  gtc agc acc aca cgt  gtg acc agc tct       11182
Pro  Leu Thr Thr Met Pro  Val Ser Thr Thr Arg  Val Thr Ser Ser            
3695                 3700                 3705                            

gag  ggt agc acc ctt tca  aca cct tct gtt gtc  acc agc aca cct       11227
Glu  Gly Ser Thr Leu Ser  Thr Pro Ser Val Val  Thr Ser Thr Pro            
3710                 3715                 3720                            

gtg  acc act tct act gaa  gcc att tca tct tct  gca act ctt gac       11272
Val  Thr Thr Ser Thr Glu  Ala Ile Ser Ser Ser  Ala Thr Leu Asp            
3725                 3730                 3735                            

agc  acc acc atg tct gtg  tca atg ccc atg gaa  ata agc acc ctt       11317
Ser  Thr Thr Met Ser Val  Ser Met Pro Met Glu  Ile Ser Thr Leu            
3740                 3745                 3750                            

ggg  acc act att ctt gtc  agt acc aca cct gtt  acg agg ttt cct       11362
Gly  Thr Thr Ile Leu Val  Ser Thr Thr Pro Val  Thr Arg Phe Pro            
3755                 3760                 3765                            

gag  agt agc acc cct tcc  ata cca tct gtt tac  acc agc atg tct       11407
Glu  Ser Ser Thr Pro Ser  Ile Pro Ser Val Tyr  Thr Ser Met Ser            
3770                 3775                 3780                            

atg  acc act gcc tct gaa  ggc agt tca tct cct  aca act ctt gaa       11452
Met  Thr Thr Ala Ser Glu  Gly Ser Ser Ser Pro  Thr Thr Leu Glu            
3785                 3790                 3795                            

ggc  acc acc acc atg cct  atg tca act acg agt  gaa aga agc act       11497
Gly  Thr Thr Thr Met Pro  Met Ser Thr Thr Ser  Glu Arg Ser Thr            
3800                 3805                 3810                            

tta  ttg aca act gtc ctc  atc agc cct ata tct  gtg atg agt cct       11542
Leu  Leu Thr Thr Val Leu  Ile Ser Pro Ile Ser  Val Met Ser Pro            
3815                 3820                 3825                            

tct  gag gcc agc aca ctt  tca aca cct cct ggt  gat acc agc aca       11587
Ser  Glu Ala Ser Thr Leu  Ser Thr Pro Pro Gly  Asp Thr Ser Thr            
3830                 3835                 3840                            

cct  ttg ctc acc tct acc  aaa gcc ggt tca ttc  tcc ata cct gct       11632
Pro  Leu Leu Thr Ser Thr  Lys Ala Gly Ser Phe  Ser Ile Pro Ala            
3845                 3850                 3855                            

gaa  gtc act acc ata cgt  att tca att acc agt  gaa aga agc act       11677
Glu  Val Thr Thr Ile Arg  Ile Ser Ile Thr Ser  Glu Arg Ser Thr            
3860                 3865                 3870                            

cca  tta aca act ctc ctt  gtc agc acc aca ctt  cca act agc ttt       11722
Pro  Leu Thr Thr Leu Leu  Val Ser Thr Thr Leu  Pro Thr Ser Phe            
3875                 3880                 3885                            

cct  ggg gcc agc ata gct  tcg aca cct cct ctt  gac aca agc aca       11767
Pro  Gly Ala Ser Ile Ala  Ser Thr Pro Pro Leu  Asp Thr Ser Thr            
3890                 3895                 3900                            

act  ttt acc cct tct act  gac act gcc tca act  ccc aca att cct       11812
Thr  Phe Thr Pro Ser Thr  Asp Thr Ala Ser Thr  Pro Thr Ile Pro            
3905                 3910                 3915                            

gta  gcc acc acc ata tct  gta tca gtg atc aca  gaa gga agc aca       11857
Val  Ala Thr Thr Ile Ser  Val Ser Val Ile Thr  Glu Gly Ser Thr            
3920                 3925                 3930                            

cct  ggg aca acc att ttt  att ccc agc act cct  gtc acc agt tct       11902
Pro  Gly Thr Thr Ile Phe  Ile Pro Ser Thr Pro  Val Thr Ser Ser            
3935                 3940                 3945                            

act  gct gat gtc ttt cct  gca aca act ggt gct  gta tct acc cct       11947
Thr  Ala Asp Val Phe Pro  Ala Thr Thr Gly Ala  Val Ser Thr Pro            
3950                 3955                 3960                            

gtg  ata act tcc act gaa  cta aac aca cca tca  acc tcc agt agt       11992
Val  Ile Thr Ser Thr Glu  Leu Asn Thr Pro Ser  Thr Ser Ser Ser            
3965                 3970                 3975                            

agt  acc acc aca tct ttt  tca act act aag gaa  ttt aca aca ccc       12037
Ser  Thr Thr Thr Ser Phe  Ser Thr Thr Lys Glu  Phe Thr Thr Pro            
3980                 3985                 3990                            

gca  atg act act gca gct  ccc ctc aca tat gtg  acc atg tct act       12082
Ala  Met Thr Thr Ala Ala  Pro Leu Thr Tyr Val  Thr Met Ser Thr            
3995                 4000                 4005                            

gcc  ccc agc aca ccc aga  aca acc agc aga ggc  tgc act act tct       12127
Ala  Pro Ser Thr Pro Arg  Thr Thr Ser Arg Gly  Cys Thr Thr Ser            
4010                 4015                 4020                            

gca  tca acg ctt tct gca  acc agt aca cct cac  acc tct act tct       12172
Ala  Ser Thr Leu Ser Ala  Thr Ser Thr Pro His  Thr Ser Thr Ser            
4025                 4030                 4035                            

gtc  acc acc cgt cct gtg  acc cct tca tca gaa  tcc agc agg ccg       12217
Val  Thr Thr Arg Pro Val  Thr Pro Ser Ser Glu  Ser Ser Arg Pro            
4040                 4045                 4050                            

tca  aca att act tct cac  acc atc cca cct aca  ttt cct cct gct       12262
Ser  Thr Ile Thr Ser His  Thr Ile Pro Pro Thr  Phe Pro Pro Ala            
4055                 4060                 4065                            

cac  tcc agt aca cct cca  aca acc tct gcc tcc  tcc acg act gtg       12307
His  Ser Ser Thr Pro Pro  Thr Thr Ser Ala Ser  Ser Thr Thr Val            
4070                 4075                 4080                            

aac  cct gag gct gtc acc  acc atg acc acc agg  aca aaa ccc agc       12352
Asn  Pro Glu Ala Val Thr  Thr Met Thr Thr Arg  Thr Lys Pro Ser            
4085                 4090                 4095                            

aca  cgg acc act tcc ttc  ccc acg gtg acc acc  acc gct gtc ccc       12397
Thr  Arg Thr Thr Ser Phe  Pro Thr Val Thr Thr  Thr Ala Val Pro            
4100                 4105                 4110                            

acg  aat act aca att aag  agc aac ccc acc tca  act cct act gtg       12442
Thr  Asn Thr Thr Ile Lys  Ser Asn Pro Thr Ser  Thr Pro Thr Val            
4115                 4120                 4125                            

cca  aga acc aca aca tgc  ttt gga gat ggg tgc  cag aat acg gcc       12487
Pro  Arg Thr Thr Thr Cys  Phe Gly Asp Gly Cys  Gln Asn Thr Ala            
4130                 4135                 4140                            

tct  cgc tgc aag aat gga  ggc acc tgg gat ggg  ctc aag tgc cag       12532
Ser  Arg Cys Lys Asn Gly  Gly Thr Trp Asp Gly  Leu Lys Cys Gln            
4145                 4150                 4155                            

tgt  ccc aac ctc tat tat  ggg gag ttg tgt gag  gag gtg gtc agc       12577
Cys  Pro Asn Leu Tyr Tyr  Gly Glu Leu Cys Glu  Glu Val Val Ser            
4160                 4165                 4170                            

agc  att gac ata ggg cca  ccg gag act atc tct  gcc caa atg gaa       12622
Ser  Ile Asp Ile Gly Pro  Pro Glu Thr Ile Ser  Ala Gln Met Glu            
4175                 4180                 4185                            

ctg  act gtg aca gtg acc  agt gtg aag ttc acc  gaa gag cta aaa       12667
Leu  Thr Val Thr Val Thr  Ser Val Lys Phe Thr  Glu Glu Leu Lys            
4190                 4195                 4200                            

aac  cac tct tcc cag gaa  ttc cag gag ttc aaa  cag aca ttc acg       12712
Asn  His Ser Ser Gln Glu  Phe Gln Glu Phe Lys  Gln Thr Phe Thr            
4205                 4210                 4215                            

gaa  cag atg aat att gtg  tat tcc ggg atc cct  gag tat gtc ggg       12757
Glu  Gln Met Asn Ile Val  Tyr Ser Gly Ile Pro  Glu Tyr Val Gly            
4220                 4225                 4230                            

gtg  aac atc aca aag cta  cgt ctt ggc agt gtg  gtg gtg gag cat       12802
Val  Asn Ile Thr Lys Leu  Arg Leu Gly Ser Val  Val Val Glu His            
4235                 4240                 4245                            

gac  gtc ctc cta aga acc  aag tac aca cca gaa  tac aag aca gta       12847
Asp  Val Leu Leu Arg Thr  Lys Tyr Thr Pro Glu  Tyr Lys Thr Val            
4250                 4255                 4260                            

ttg  gac aat gcc acc gaa  gta gtg aaa gag aaa  atc aca aaa gtg       12892
Leu  Asp Asn Ala Thr Glu  Val Val Lys Glu Lys  Ile Thr Lys Val            
4265                 4270                 4275                            

acc  aca cag caa ata atg  att aat gat att tgc  tca gac atg atg       12937
Thr  Thr Gln Gln Ile Met  Ile Asn Asp Ile Cys  Ser Asp Met Met            
4280                 4285                 4290                            

tgt  ttc aac acc act ggc  acc caa gtg caa aac  att acg gtg acc       12982
Cys  Phe Asn Thr Thr Gly  Thr Gln Val Gln Asn  Ile Thr Val Thr            
4295                 4300                 4305                            

cag  tac gac cct gaa gag  gac tgc cgg aag atg  gcc aag gaa tat       13027
Gln  Tyr Asp Pro Glu Glu  Asp Cys Arg Lys Met  Ala Lys Glu Tyr            
4310                 4315                 4320                            

gga  gac tac ttc gta gtg  gag tac cgg gac cag  aag cca tac tgc       13072
Gly  Asp Tyr Phe Val Val  Glu Tyr Arg Asp Gln  Lys Pro Tyr Cys            
4325                 4330                 4335                            

atc  agc ccc tgt gag cct  ggc ttc agt gtc tcc  aag aac tgt aac       13117
Ile  Ser Pro Cys Glu Pro  Gly Phe Ser Val Ser  Lys Asn Cys Asn            
4340                 4345                 4350                            

ctc  ggc aag tgc cag atg  tct cta agt gga cct  cag tgc ctc tgc       13162
Leu  Gly Lys Cys Gln Met  Ser Leu Ser Gly Pro  Gln Cys Leu Cys            
4355                 4360                 4365                            

gtg  acc acg gaa act cac  tgg tac agt ggg gag  acc tgt aac cag       13207
Val  Thr Thr Glu Thr His  Trp Tyr Ser Gly Glu  Thr Cys Asn Gln            
4370                 4375                 4380                            

ggc  acc cag aag agt ctg  gtg tac ggc ctc gtg  ggg gca ggg gtc       13252
Gly  Thr Gln Lys Ser Leu  Val Tyr Gly Leu Val  Gly Ala Gly Val            
4385                 4390                 4395                            

gtg  ctg atg ctg atc atc  ctg gta gct ctc ctg  atg ctc gtt ttc       13297
Val  Leu Met Leu Ile Ile  Leu Val Ala Leu Leu  Met Leu Val Phe            
4400                 4405                 4410                            

cgc  tcc aag aga gag gtg  aaa cgg caa aag tac  aga ttg tct cag       13342
Arg  Ser Lys Arg Glu Val  Lys Arg Gln Lys Tyr  Arg Leu Ser Gln            
4415                 4420                 4425                            

tta  tac aag tgg caa gaa  gag gac agt gga cca  gct cct ggg acc       13387
Leu  Tyr Lys Trp Gln Glu  Glu Asp Ser Gly Pro  Ala Pro Gly Thr            
4430                 4435                 4440                            

ttc  caa aac att ggc ttt  gac atc tgc caa gat  gat gat tcc atc       13432
Phe  Gln Asn Ile Gly Phe  Asp Ile Cys Gln Asp  Asp Asp Ser Ile            
4445                 4450                 4455                            

cac  ctg gag tcc atc tat  agt aat ttc cag ccc  tcc ttg aga cac       13477
His  Leu Glu Ser Ile Tyr  Ser Asn Phe Gln Pro  Ser Leu Arg His            
4460                 4465                 4470                            

ata  gac cct gaa aca aag  atc cga att cag agg  cct cag gta atg       13522
Ile  Asp Pro Glu Thr Lys  Ile Arg Ile Gln Arg  Pro Gln Val Met            
4475                 4480                 4485                            

acg  aca tca ttt taa ggcatggagc tgagaagtct gggagtgagg agatcccagt     13577
Thr  Thr Ser Phe                                                          
4490                                                                      

ccggctaagc ttggtggagc attttcccat tgagagcctt ccatgggaac tcaatgttcc    13637

cattgtaagt acaggaaaca agccctgtac ttaccaagga gaaagaggag agacagcagt    13697

gctgggagat tctcaaatag aaacccgtgg acgctccaat gggcttgtca tgatatcagg    13757

ctaggctttc ctgctcattt ttcaaagacg ctccagattt gagggtactc tgactgcaac    13817

atctttcacc ccattgatcg ccaggattga tttggttgat ctggctgagc aggcgggtgt    13877

ccccgtcctc cctcactgcc ccatatgtgt ccctcctaaa gctgcatgct cagttgaaga    13937

ggacgagagg acgaccttct ctgatagagg aggaccacgc ttcagtcaaa ggcatacaag    13997

tatctatctg gacttccctg ctagcacttc caaacaagct cagagatgtt cctcccctca    14057

tctgcccggg ttcagtacca tggacagcgc cctcgacccg ctgtttacaa ccatgacccc    14117

ttggacactg gactgcatgc actttacata tcacaaaatg ctctcataag aattattgca    14177

taccatcttc atgaaaaaca cctgtattta aatatagagc atttaccttt tggtatataa    14237

gattgtgggt attttttaag ttcttattgt tatgagttct gattttttcc ttagtaaata    14297

ttataatata tatttgtagt aactaaaaat aataaagcaa ttttattaca atttt         14352


<210>  38
<211>  4493
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Pro Arg Pro Gly Thr Met Ala Leu Cys Leu Leu Thr Leu Val Leu 
1               5                   10                  15      


Ser Leu Leu Pro Pro Gln Ala Ala Ala Glu Gln Asp Leu Ser Val Asn 
            20                  25                  30          


Arg Ala Val Trp Asp Gly Gly Gly Cys Ile Ser Gln Gly Asp Val Leu 
        35                  40                  45              


Asn Arg Gln Cys Gln Gln Leu Ser Gln His Val Arg Thr Gly Ser Ala 
    50                  55                  60                  


Ala Asn Thr Ala Thr Gly Thr Thr Ser Thr Asn Val Val Glu Pro Arg 
65                  70                  75                  80  


Met Tyr Leu Ser Cys Ser Thr Asn Pro Glu Met Thr Ser Ile Glu Ser 
                85                  90                  95      


Ser Val Thr Ser Asp Thr Pro Gly Val Ser Ser Thr Arg Met Thr Pro 
            100                 105                 110         


Thr Glu Ser Arg Thr Thr Ser Glu Ser Thr Ser Asp Ser Thr Thr Leu 
        115                 120                 125             


Phe Pro Ser Ser Thr Glu Asp Thr Ser Ser Pro Thr Thr Pro Glu Gly 
    130                 135                 140                 


Thr Asp Val Pro Met Ser Thr Pro Ser Glu Glu Ser Ile Ser Ser Thr 
145                 150                 155                 160 


Met Ala Phe Val Ser Thr Ala Pro Leu Pro Ser Phe Glu Ala Tyr Thr 
                165                 170                 175     


Ser Leu Thr Tyr Lys Val Asp Met Ser Thr Pro Leu Thr Thr Ser Thr 
            180                 185                 190         


Gln Ala Ser Ser Ser Pro Thr Thr Pro Glu Ser Thr Thr Ile Pro Lys 
        195                 200                 205             


Ser Thr Asn Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Ala Ser 
    210                 215                 220                 


Thr Met Lys Val Ala Ser Ser Glu Ala Ile Thr Leu Leu Thr Thr Pro 
225                 230                 235                 240 


Val Glu Ile Ser Thr Pro Val Thr Ile Ser Ala Gln Ala Ser Ser Ser 
                245                 250                 255     


Pro Thr Thr Ala Glu Gly Pro Ser Leu Ser Asn Ser Ala Pro Ser Gly 
            260                 265                 270         


Gly Ser Thr Pro Leu Thr Arg Met Pro Leu Ser Val Met Leu Val Val 
        275                 280                 285             


Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Ala Ala Thr Asn Ile 
    290                 295                 300                 


Pro Val Ile Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Glu 
305                 310                 315                 320 


Gly Thr Ser Ile Pro Thr Ser Thr Tyr Thr Glu Gly Ser Thr Pro Leu 
                325                 330                 335     


Thr Ser Thr Pro Ala Ser Thr Met Pro Val Ala Thr Ser Glu Met Ser 
            340                 345                 350         


Thr Leu Ser Ile Thr Pro Val Asp Thr Ser Thr Leu Val Thr Thr Ser 
        355                 360                 365             


Thr Glu Pro Ser Ser Leu Pro Thr Thr Ala Glu Ala Thr Ser Met Leu 
    370                 375                 380                 


Thr Ser Thr Leu Ser Glu Gly Ser Thr Pro Leu Thr Asn Met Pro Val 
385                 390                 395                 400 


Ser Thr Ile Leu Val Ala Ser Ser Glu Ala Ser Thr Thr Ser Thr Ile 
                405                 410                 415     


Pro Val Asp Ser Lys Thr Phe Val Thr Thr Ala Ser Glu Ala Ser Ser 
            420                 425                 430         


Ser Pro Thr Thr Ala Glu Asp Thr Ser Ile Ala Thr Ser Thr Pro Ser 
        435                 440                 445             


Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Val Ser Thr Thr Pro Val 
    450                 455                 460                 


Ala Ser Ser Glu Ala Ser Asn Leu Ser Thr Thr Pro Val Asp Ser Lys 
465                 470                 475                 480 


Thr Gln Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Pro Thr Ala 
                485                 490                 495     


Glu Val Asn Ser Met Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro 
            500                 505                 510         


Leu Thr Ser Met Ser Val Ser Thr Met Pro Val Ala Ser Ser Glu Ala 
        515                 520                 525             


Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr 
    530                 535                 540                 


Ser Ser Glu Ala Ser Ser Ser Ser Thr Thr Pro Glu Gly Thr Ser Ile 
545                 550                 555                 560 


Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Asn Met Pro 
                565                 570                 575     


Val Ser Thr Arg Leu Val Val Ser Ser Glu Ala Ser Thr Thr Ser Thr 
            580                 585                 590         


Thr Pro Ala Asp Ser Asn Thr Phe Val Thr Thr Ser Ser Glu Ala Ser 
        595                 600                 605             


Ser Ser Ser Thr Thr Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr 
    610                 615                 620                 


Ser Glu Arg Gly Thr Thr Ile Thr Ser Met Ser Val Ser Thr Thr Leu 
625                 630                 635                 640 


Val Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Ser 
                645                 650                 655     


Asn Thr Pro Val Thr Thr Ser Thr Glu Ala Thr Ser Ser Ser Thr Thr 
            660                 665                 670         


Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Thr Glu Gly Ser Thr 
        675                 680                 685             


Pro Leu Thr Ser Met Pro Val Asn Thr Thr Leu Val Ala Ser Ser Glu 
    690                 695                 700                 


Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr 
705                 710                 715                 720 


Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Asp Gly Ala Ser 
                725                 730                 735     


Met Pro Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Ser Met 
            740                 745                 750         


Pro Val Ser Lys Thr Leu Leu Thr Ser Ser Glu Ala Ser Thr Leu Ser 
        755                 760                 765             


Thr Thr Pro Leu Asp Thr Ser Thr His Ile Thr Thr Ser Thr Glu Ala 
    770                 775                 780                 


Ser Cys Ser Pro Thr Thr Thr Glu Gly Thr Ser Met Pro Ile Ser Thr 
785                 790                 795                 800 


Pro Ser Glu Gly Ser Pro Leu Leu Thr Ser Ile Pro Val Ser Ile Thr 
                805                 810                 815     


Pro Val Thr Ser Pro Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp 
            820                 825                 830         


Ser Asn Ser Pro Val Thr Thr Ser Thr Glu Val Ser Ser Ser Pro Thr 
        835                 840                 845             


Pro Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser Glu Gly Arg 
    850                 855                 860                 


Thr Pro Leu Thr Ser Met Pro Val Ser Thr Thr Leu Val Ala Thr Ser 
865                 870                 875                 880 


Ala Ile Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val 
                885                 890                 895     


Thr Asn Ser Thr Glu Ala Arg Ser Ser Pro Thr Thr Ser Glu Gly Thr 
            900                 905                 910         


Ser Met Pro Thr Ser Thr Pro Gly Glu Gly Ser Thr Pro Leu Thr Ser 
        915                 920                 925             


Met Pro Asp Ser Thr Thr Pro Val Val Ser Ser Glu Ala Arg Thr Leu 
    930                 935                 940                 


Ser Ala Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser Thr Glu 
945                 950                 955                 960 


Ala Thr Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Ile Pro Thr Ser 
                965                 970                 975     


Thr Pro Ser Glu Gly Thr Thr Pro Leu Thr Ser Thr Pro Val Ser His 
            980                 985                 990         


Thr Leu Val Ala Asn Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
        995                 1000                 1005             


Asp Ser  Asn Thr Pro Leu Thr  Thr Ser Thr Glu Ala  Ser Ser Pro 
    1010                 1015                 1020             


Pro Pro  Thr Ala Glu Gly Thr  Ser Met Pro Thr Ser  Thr Pro Ser 
    1025                 1030                 1035             


Glu Gly  Ser Thr Pro Leu Thr  Arg Met Pro Val Ser  Thr Thr Met 
    1040                 1045                 1050             


Val Ala  Ser Ser Glu Thr Ser  Thr Leu Ser Thr Thr  Pro Ala Asp 
    1055                 1060                 1065             


Thr Ser  Thr Pro Val Thr Thr  Tyr Ser Gln Ala Ser  Ser Ser Ser 
    1070                 1075                 1080             


Thr Thr  Ala Asp Gly Thr Ser  Met Pro Thr Ser Thr  Tyr Ser Glu 
    1085                 1090                 1095             


Gly Ser  Thr Pro Leu Thr Ser  Val Pro Val Ser Thr  Arg Leu Val 
    1100                 1105                 1110             


Val Ser  Ser Glu Ala Ser Thr  Leu Ser Thr Thr Pro  Val Asp Thr 
    1115                 1120                 1125             


Ser Ile  Pro Val Thr Thr Ser  Thr Glu Ala Ser Ser  Ser Pro Thr 
    1130                 1135                 1140             


Thr Ala  Glu Gly Thr Ser Ile  Pro Thr Ser Pro Pro  Ser Glu Gly 
    1145                 1150                 1155             


Thr Thr  Pro Leu Ala Ser Met  Pro Val Ser Thr Thr  Leu Val Val 
    1160                 1165                 1170             


Ser Ser  Glu Ala Asn Thr Leu  Ser Thr Thr Pro Val  Asp Ser Lys 
    1175                 1180                 1185             


Thr Gln  Val Ala Thr Ser Thr  Glu Ala Ser Ser Pro  Pro Pro Thr 
    1190                 1195                 1200             


Ala Glu  Val Thr Ser Met Pro  Thr Ser Thr Pro Gly  Glu Arg Ser 
    1205                 1210                 1215             


Thr Pro  Leu Thr Ser Met Pro  Val Arg His Thr Pro  Val Ala Ser 
    1220                 1225                 1230             


Ser Glu  Ala Ser Thr Leu Ser  Thr Ser Pro Val Asp  Thr Ser Thr 
    1235                 1240                 1245             


Pro Val  Thr Thr Ser Ala Glu  Thr Ser Ser Ser Pro  Thr Thr Ala 
    1250                 1255                 1260             


Glu Gly  Thr Ser Leu Pro Thr  Ser Thr Thr Ser Glu  Gly Ser Thr 
    1265                 1270                 1275             


Leu Leu  Thr Ser Ile Pro Val  Ser Thr Thr Leu Val  Thr Ser Pro 
    1280                 1285                 1290             


Glu Ala  Ser Thr Leu Leu Thr  Thr Pro Val Asp Thr  Lys Gly Pro 
    1295                 1300                 1305             


Val Val  Thr Ser Asn Glu Val  Ser Ser Ser Pro Thr  Pro Ala Glu 
    1310                 1315                 1320             


Gly Thr  Ser Met Pro Thr Ser  Thr Tyr Ser Glu Gly  Arg Thr Pro 
    1325                 1330                 1335             


Leu Thr  Ser Ile Pro Val Asn  Thr Thr Leu Val Ala  Ser Ser Ala 
    1340                 1345                 1350             


Ile Ser  Ile Leu Ser Thr Thr  Pro Val Asp Asn Ser  Thr Pro Val 
    1355                 1360                 1365             


Thr Thr  Ser Thr Glu Ala Cys  Ser Ser Pro Thr Thr  Ser Glu Gly 
    1370                 1375                 1380             


Thr Ser  Met Pro Asn Ser Asn  Pro Ser Glu Gly Thr  Thr Pro Leu 
    1385                 1390                 1395             


Thr Ser  Ile Pro Val Ser Thr  Thr Pro Val Val Ser  Ser Glu Ala 
    1400                 1405                 1410             


Ser Thr  Leu Ser Ala Thr Pro  Val Asp Thr Ser Thr  Pro Gly Thr 
    1415                 1420                 1425             


Thr Ser  Ala Glu Ala Thr Ser  Ser Pro Thr Thr Ala  Glu Gly Ile 
    1430                 1435                 1440             


Ser Ile  Pro Thr Ser Thr Pro  Ser Glu Gly Lys Thr  Pro Leu Lys 
    1445                 1450                 1455             


Ser Ile  Pro Val Ser Asn Thr  Pro Val Ala Asn Ser  Glu Ala Ser 
    1460                 1465                 1470             


Thr Leu  Ser Thr Thr Pro Val  Asp Ser Asn Ser Pro  Val Val Thr 
    1475                 1480                 1485             


Ser Thr  Ala Val Ser Ser Ser  Pro Thr Pro Ala Glu  Gly Thr Ser 
    1490                 1495                 1500             


Ile Ala  Ile Ser Thr Pro Ser  Glu Gly Ser Thr Ala  Leu Thr Ser 
    1505                 1510                 1515             


Ile Pro  Val Ser Thr Thr Thr  Val Ala Ser Ser Glu  Ile Asn Ser 
    1520                 1525                 1530             


Leu Ser  Thr Thr Pro Ala Val  Thr Ser Thr Pro Val  Thr Thr Tyr 
    1535                 1540                 1545             


Ser Gln  Ala Ser Ser Ser Pro  Thr Thr Ala Asp Gly  Thr Ser Met 
    1550                 1555                 1560             


Gln Thr  Ser Thr Tyr Ser Glu  Gly Ser Thr Pro Leu  Thr Ser Leu 
    1565                 1570                 1575             


Pro Val  Ser Thr Met Leu Val  Val Ser Ser Glu Ala  Asn Thr Leu 
    1580                 1585                 1590             


Ser Thr  Thr Pro Ile Asp Ser  Lys Thr Gln Val Thr  Ala Ser Thr 
    1595                 1600                 1605             


Glu Ala  Ser Ser Ser Thr Thr  Ala Glu Gly Ser Ser  Met Thr Ile 
    1610                 1615                 1620             


Ser Thr  Pro Ser Glu Gly Ser  Pro Leu Leu Thr Ser  Ile Pro Val 
    1625                 1630                 1635             


Ser Thr  Thr Pro Val Ala Ser  Pro Glu Ala Ser Thr  Leu Ser Thr 
    1640                 1645                 1650             


Thr Pro  Val Asp Ser Asn Ser  Pro Val Ile Thr Ser  Thr Glu Val 
    1655                 1660                 1665             


Ser Ser  Ser Pro Thr Pro Ala  Glu Gly Thr Ser Met  Pro Thr Ser 
    1670                 1675                 1680             


Thr Tyr  Thr Glu Gly Arg Thr  Pro Leu Thr Ser Ile  Thr Val Arg 
    1685                 1690                 1695             


Thr Thr  Pro Val Ala Ser Ser  Ala Ile Ser Thr Leu  Ser Thr Thr 
    1700                 1705                 1710             


Pro Val  Asp Asn Ser Thr Pro  Val Thr Thr Ser Thr  Glu Ala Arg 
    1715                 1720                 1725             


Ser Ser  Pro Thr Thr Ser Glu  Gly Thr Ser Met Pro  Asn Ser Thr 
    1730                 1735                 1740             


Pro Ser  Glu Gly Thr Thr Pro  Leu Thr Ser Ile Pro  Val Ser Thr 
    1745                 1750                 1755             


Thr Pro  Val Leu Ser Ser Glu  Ala Ser Thr Leu Ser  Ala Thr Pro 
    1760                 1765                 1770             


Ile Asp  Thr Ser Thr Pro Val  Thr Thr Ser Thr Glu  Ala Thr Ser 
    1775                 1780                 1785             


Ser Pro  Thr Thr Ala Glu Gly  Thr Ser Ile Pro Thr  Ser Thr Leu 
    1790                 1795                 1800             


Ser Glu  Gly Met Thr Pro Leu  Thr Ser Thr Pro Val  Ser His Thr 
    1805                 1810                 1815             


Leu Val  Ala Asn Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
    1820                 1825                 1830             


Asp Ser  Asn Ser Pro Val Val  Thr Ser Thr Ala Val  Ser Ser Ser 
    1835                 1840                 1845             


Pro Thr  Pro Ala Glu Gly Thr  Ser Ile Ala Thr Ser  Thr Pro Ser 
    1850                 1855                 1860             


Glu Gly  Ser Thr Ala Leu Thr  Ser Ile Pro Val Ser  Thr Thr Thr 
    1865                 1870                 1875             


Val Ala  Ser Ser Glu Thr Asn  Thr Leu Ser Thr Thr  Pro Ala Val 
    1880                 1885                 1890             


Thr Ser  Thr Pro Val Thr Thr  Tyr Ala Gln Val Ser  Ser Ser Pro 
    1895                 1900                 1905             


Thr Thr  Ala Asp Gly Ser Ser  Met Pro Thr Ser Thr  Pro Arg Glu 
    1910                 1915                 1920             


Gly Arg  Pro Pro Leu Thr Ser  Ile Pro Val Ser Thr  Thr Thr Val 
    1925                 1930                 1935             


Ala Ser  Ser Glu Ile Asn Thr  Leu Ser Thr Thr Leu  Ala Asp Thr 
    1940                 1945                 1950             


Arg Thr  Pro Val Thr Thr Tyr  Ser Gln Ala Ser Ser  Ser Pro Thr 
    1955                 1960                 1965             


Thr Ala  Asp Gly Thr Ser Met  Pro Thr Pro Ala Tyr  Ser Glu Gly 
    1970                 1975                 1980             


Ser Thr  Pro Leu Thr Ser Met  Pro Leu Ser Thr Thr  Leu Val Val 
    1985                 1990                 1995             


Ser Ser  Glu Ala Ser Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser 
    2000                 2005                 2010             


Thr Pro  Ala Thr Thr Ser Thr  Glu Gly Ser Ser Ser  Pro Thr Thr 
    2015                 2020                 2025             


Ala Gly  Gly Thr Ser Ile Gln  Thr Ser Thr Pro Ser  Glu Arg Thr 
    2030                 2035                 2040             


Thr Pro  Leu Ala Gly Met Pro  Val Ser Thr Thr Leu  Val Val Ser 
    2045                 2050                 2055             


Ser Glu  Gly Asn Thr Leu Ser  Thr Thr Pro Val Asp  Ser Lys Thr 
    2060                 2065                 2070             


Gln Val  Thr Asn Ser Thr Glu  Ala Ser Ser Ser Ala  Thr Ala Glu 
    2075                 2080                 2085             


Gly Ser  Ser Met Thr Ile Ser  Ala Pro Ser Glu Gly  Ser Pro Leu 
    2090                 2095                 2100             


Leu Thr  Ser Ile Pro Leu Ser  Thr Thr Pro Val Ala  Ser Pro Glu 
    2105                 2110                 2115             


Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp Ser Asn  Ser Pro Val 
    2120                 2125                 2130             


Ile Thr  Ser Thr Glu Val Ser  Ser Ser Pro Ile Pro  Thr Glu Gly 
    2135                 2140                 2145             


Thr Ser  Met Gln Thr Ser Thr  Tyr Ser Asp Arg Arg  Thr Pro Leu 
    2150                 2155                 2160             


Thr Ser  Met Pro Val Ser Thr  Thr Val Val Ala Ser  Ser Ala Ile 
    2165                 2170                 2175             


Ser Thr  Leu Ser Thr Thr Pro  Val Asp Thr Ser Thr  Pro Val Thr 
    2180                 2185                 2190             


Asn Ser  Thr Glu Ala Arg Ser  Ser Pro Thr Thr Ser  Glu Gly Thr 
    2195                 2200                 2205             


Ser Met  Pro Thr Ser Thr Pro  Ser Glu Gly Ser Thr  Pro Phe Thr 
    2210                 2215                 2220             


Ser Met  Pro Val Ser Thr Met  Pro Val Val Thr Ser  Glu Ala Ser 
    2225                 2230                 2235             


Thr Leu  Ser Ala Thr Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr 
    2240                 2245                 2250             


Ser Thr  Glu Ala Thr Ser Ser  Pro Thr Thr Ala Glu  Gly Thr Ser 
    2255                 2260                 2265             


Ile Pro  Thr Ser Thr Leu Ser  Glu Gly Thr Thr Pro  Leu Thr Ser 
    2270                 2275                 2280             


Ile Pro  Val Ser His Thr Leu  Val Ala Asn Ser Glu  Val Ser Thr 
    2285                 2290                 2295             


Leu Ser  Thr Thr Pro Val Asp  Ser Asn Thr Pro Phe  Thr Thr Ser 
    2300                 2305                 2310             


Thr Glu  Ala Ser Ser Pro Pro  Pro Thr Ala Glu Gly  Thr Ser Met 
    2315                 2320                 2325             


Pro Thr  Ser Thr Ser Ser Glu  Gly Asn Thr Pro Leu  Thr Arg Met 
    2330                 2335                 2340             


Pro Val  Ser Thr Thr Met Val  Ala Ser Phe Glu Thr  Ser Thr Leu 
    2345                 2350                 2355             


Ser Thr  Thr Pro Ala Asp Thr  Ser Thr Pro Val Thr  Thr Tyr Ser 
    2360                 2365                 2370             


Gln Ala  Gly Ser Ser Pro Thr  Thr Ala Asp Asp Thr  Ser Met Pro 
    2375                 2380                 2385             


Thr Ser  Thr Tyr Ser Glu Gly  Ser Thr Pro Leu Thr  Ser Val Pro 
    2390                 2395                 2400             


Val Ser  Thr Met Pro Val Val  Ser Ser Glu Ala Ser  Thr His Ser 
    2405                 2410                 2415             


Thr Thr  Pro Val Asp Thr Ser  Thr Pro Val Thr Thr  Ser Thr Glu 
    2420                 2425                 2430             


Ala Ser  Ser Ser Pro Thr Thr  Ala Glu Gly Thr Ser  Ile Pro Thr 
    2435                 2440                 2445             


Ser Pro  Pro Ser Glu Gly Thr  Thr Pro Leu Ala Ser  Met Pro Val 
    2450                 2455                 2460             


Ser Thr  Thr Pro Val Val Ser  Ser Glu Ala Gly Thr  Leu Ser Thr 
    2465                 2470                 2475             


Thr Pro  Val Asp Thr Ser Thr  Pro Met Thr Thr Ser  Thr Glu Ala 
    2480                 2485                 2490             


Ser Ser  Ser Pro Thr Thr Ala  Glu Asp Ile Val Val  Pro Ile Ser 
    2495                 2500                 2505             


Thr Ala  Ser Glu Gly Ser Thr  Leu Leu Thr Ser Ile  Pro Val Ser 
    2510                 2515                 2520             


Thr Thr  Pro Val Ala Ser Pro  Glu Ala Ser Thr Leu  Ser Thr Thr 
    2525                 2530                 2535             


Pro Val  Asp Ser Asn Ser Pro  Val Val Thr Ser Thr  Glu Ile Ser 
    2540                 2545                 2550             


Ser Ser  Ala Thr Ser Ala Glu  Gly Thr Ser Met Pro  Thr Ser Thr 
    2555                 2560                 2565             


Tyr Ser  Glu Gly Ser Thr Pro  Leu Arg Ser Met Pro  Val Ser Thr 
    2570                 2575                 2580             


Lys Pro  Leu Ala Ser Ser Glu  Ala Ser Thr Leu Ser  Thr Thr Pro 
    2585                 2590                 2595             


Val Asp  Thr Ser Ile Pro Val  Thr Thr Ser Thr Glu  Thr Ser Ser 
    2600                 2605                 2610             


Ser Pro  Thr Thr Ala Lys Asp  Thr Ser Met Pro Ile  Ser Thr Pro 
    2615                 2620                 2625             


Ser Glu  Val Ser Thr Ser Leu  Thr Ser Ile Leu Val  Ser Thr Met 
    2630                 2635                 2640             


Pro Val  Ala Ser Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
    2645                 2650                 2655             


Asp Thr  Arg Thr Leu Val Thr  Thr Ser Thr Gly Thr  Ser Ser Ser 
    2660                 2665                 2670             


Pro Thr  Thr Ala Glu Gly Ser  Ser Met Pro Thr Ser  Thr Pro Gly 
    2675                 2680                 2685             


Glu Arg  Ser Thr Pro Leu Thr  Asn Ile Leu Val Ser  Thr Thr Leu 
    2690                 2695                 2700             


Leu Ala  Asn Ser Glu Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp 
    2705                 2710                 2715             


Thr Ser  Thr Pro Val Thr Thr  Ser Ala Glu Ala Ser  Ser Ser Pro 
    2720                 2725                 2730             


Thr Thr  Ala Glu Gly Thr Ser  Met Arg Ile Ser Thr  Pro Ser Asp 
    2735                 2740                 2745             


Gly Ser  Thr Pro Leu Thr Ser  Ile Leu Val Ser Thr  Leu Pro Val 
    2750                 2755                 2760             


Ala Ser  Ser Glu Ala Ser Thr  Val Ser Thr Thr Ala  Val Asp Thr 
    2765                 2770                 2775             


Ser Ile  Pro Val Thr Thr Ser  Thr Glu Ala Ser Ser  Ser Pro Thr 
    2780                 2785                 2790             


Thr Ala  Glu Val Thr Ser Met  Pro Thr Ser Thr Pro  Ser Glu Thr 
    2795                 2800                 2805             


Ser Thr  Pro Leu Thr Ser Met  Pro Val Asn His Thr  Pro Val Ala 
    2810                 2815                 2820             


Ser Ser  Glu Ala Gly Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser 
    2825                 2830                 2835             


Thr Pro  Val Thr Thr Ser Thr  Lys Ala Ser Ser Ser  Pro Thr Thr 
    2840                 2845                 2850             


Ala Glu  Gly Ile Val Val Pro  Ile Ser Thr Ala Ser  Glu Gly Ser 
    2855                 2860                 2865             


Thr Leu  Leu Thr Ser Ile Pro  Val Ser Thr Thr Pro  Val Ala Ser 
    2870                 2875                 2880             


Ser Glu  Ala Ser Thr Leu Ser  Thr Thr Pro Val Asp  Thr Ser Ile 
    2885                 2890                 2895             


Pro Val  Thr Thr Ser Thr Glu  Gly Ser Ser Ser Pro  Thr Thr Ala 
    2900                 2905                 2910             


Glu Gly  Thr Ser Met Pro Ile  Ser Thr Pro Ser Glu  Val Ser Thr 
    2915                 2920                 2925             


Pro Leu  Thr Ser Ile Leu Val  Ser Thr Val Pro Val  Ala Gly Ser 
    2930                 2935                 2940             


Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val Asp Thr  Arg Thr Pro 
    2945                 2950                 2955             


Val Thr  Thr Ser Ala Glu Ala  Ser Ser Ser Pro Thr  Thr Ala Glu 
    2960                 2965                 2970             


Gly Thr  Ser Met Pro Ile Ser  Thr Pro Gly Glu Arg  Arg Thr Pro 
    2975                 2980                 2985             


Leu Thr  Ser Met Ser Val Ser  Thr Met Pro Val Ala  Ser Ser Glu 
    2990                 2995                 3000             


Ala Ser  Thr Leu Ser Arg Thr  Pro Ala Asp Thr Ser  Thr Pro Val 
    3005                 3010                 3015             


Thr Thr  Ser Thr Glu Ala Ser  Ser Ser Pro Thr Thr  Ala Glu Gly 
    3020                 3025                 3030             


Thr Gly  Ile Pro Ile Ser Thr  Pro Ser Glu Gly Ser  Thr Pro Leu 
    3035                 3040                 3045             


Thr Ser  Ile Pro Val Ser Thr  Thr Pro Val Ala Ile  Pro Glu Ala 
    3050                 3055                 3060             


Ser Thr  Leu Ser Thr Thr Pro  Val Asp Ser Asn Ser  Pro Val Val 
    3065                 3070                 3075             


Thr Ser  Thr Glu Val Ser Ser  Ser Pro Thr Pro Ala  Glu Gly Thr 
    3080                 3085                 3090             


Ser Met  Pro Ile Ser Thr Tyr  Ser Glu Gly Ser Thr  Pro Leu Thr 
    3095                 3100                 3105             


Gly Val  Pro Val Ser Thr Thr  Pro Val Thr Ser Ser  Ala Ile Ser 
    3110                 3115                 3120             


Thr Leu  Ser Thr Thr Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr 
    3125                 3130                 3135             


Ser Thr  Glu Ala His Ser Ser  Pro Thr Thr Ser Glu  Gly Thr Ser 
    3140                 3145                 3150             


Met Pro  Thr Ser Thr Pro Ser  Glu Gly Ser Thr Pro  Leu Thr Tyr 
    3155                 3160                 3165             


Met Pro  Val Ser Thr Met Leu  Val Val Ser Ser Glu  Asp Ser Thr 
    3170                 3175                 3180             


Leu Ser  Ala Thr Pro Val Asp  Thr Ser Thr Pro Val  Thr Thr Ser 
    3185                 3190                 3195             


Thr Glu  Ala Thr Ser Ser Thr  Thr Ala Glu Gly Thr  Ser Ile Pro 
    3200                 3205                 3210             


Thr Ser  Thr Pro Ser Glu Gly  Met Thr Pro Leu Thr  Ser Val Pro 
    3215                 3220                 3225             


Val Ser  Asn Thr Pro Val Ala  Ser Ser Glu Ala Ser  Ile Leu Ser 
    3230                 3235                 3240             


Thr Thr  Pro Val Asp Ser Asn  Thr Pro Leu Thr Thr  Ser Thr Glu 
    3245                 3250                 3255             


Ala Ser  Ser Ser Pro Pro Thr  Ala Glu Gly Thr Ser  Met Pro Thr 
    3260                 3265                 3270             


Ser Thr  Pro Ser Glu Gly Ser  Thr Pro Leu Thr Ser  Met Pro Val 
    3275                 3280                 3285             


Ser Thr  Thr Thr Val Ala Ser  Ser Glu Thr Ser Thr  Leu Ser Thr 
    3290                 3295                 3300             


Thr Pro  Ala Asp Thr Ser Thr  Pro Val Thr Thr Tyr  Ser Gln Ala 
    3305                 3310                 3315             


Ser Ser  Ser Pro Pro Ile Ala  Asp Gly Thr Ser Met  Pro Thr Ser 
    3320                 3325                 3330             


Thr Tyr  Ser Glu Gly Ser Thr  Pro Leu Thr Asn Met  Ser Phe Ser 
    3335                 3340                 3345             


Thr Thr  Pro Val Val Ser Ser  Glu Ala Ser Thr Leu  Ser Thr Thr 
    3350                 3355                 3360             


Pro Val  Asp Thr Ser Thr Pro  Val Thr Thr Ser Thr  Glu Ala Ser 
    3365                 3370                 3375             


Leu Ser  Pro Thr Thr Ala Glu  Gly Thr Ser Ile Pro  Thr Ser Ser 
    3380                 3385                 3390             


Pro Ser  Glu Gly Thr Thr Pro  Leu Ala Ser Met Pro  Val Ser Thr 
    3395                 3400                 3405             


Thr Pro  Val Val Ser Ser Glu  Val Asn Thr Leu Ser  Thr Thr Pro 
    3410                 3415                 3420             


Val Asp  Ser Asn Thr Leu Val  Thr Thr Ser Thr Glu  Ala Ser Ser 
    3425                 3430                 3435             


Ser Pro  Thr Ile Ala Glu Gly  Thr Ser Leu Pro Thr  Ser Thr Thr 
    3440                 3445                 3450             


Ser Glu  Gly Ser Thr Pro Leu  Ser Ile Met Pro Leu  Ser Thr Thr 
    3455                 3460                 3465             


Pro Val  Ala Ser Ser Glu Ala  Ser Thr Leu Ser Thr  Thr Pro Val 
    3470                 3475                 3480             


Asp Thr  Ser Thr Pro Val Thr  Thr Ser Ser Pro Thr  Asn Ser Ser 
    3485                 3490                 3495             


Pro Thr  Thr Ala Glu Val Thr  Ser Met Pro Thr Ser  Thr Ala Gly 
    3500                 3505                 3510             


Glu Gly  Ser Thr Pro Leu Thr  Asn Met Pro Val Ser  Thr Thr Pro 
    3515                 3520                 3525             


Val Ala  Ser Ser Glu Ala Ser  Thr Leu Ser Thr Thr  Pro Val Asp 
    3530                 3535                 3540             


Ser Asn  Thr Phe Val Thr Ser  Ser Ser Gln Ala Ser  Ser Ser Pro 
    3545                 3550                 3555             


Ala Thr  Leu Gln Val Thr Thr  Met Arg Met Ser Thr  Pro Ser Glu 
    3560                 3565                 3570             


Gly Ser  Ser Ser Leu Thr Thr  Met Leu Leu Ser Ser  Thr Tyr Val 
    3575                 3580                 3585             


Thr Ser  Ser Glu Ala Ser Thr  Pro Ser Thr Pro Ser  Val Asp Arg 
    3590                 3595                 3600             


Ser Thr  Pro Val Thr Thr Ser  Thr Gln Ser Asn Ser  Thr Pro Thr 
    3605                 3610                 3615             


Pro Pro  Glu Val Ile Thr Leu  Pro Met Ser Thr Pro  Ser Glu Val 
    3620                 3625                 3630             


Ser Thr  Pro Leu Thr Ile Met  Pro Val Ser Thr Thr  Ser Val Thr 
    3635                 3640                 3645             


Ile Ser  Glu Ala Gly Thr Ala  Ser Thr Leu Pro Val  Asp Thr Ser 
    3650                 3655                 3660             


Thr Pro  Val Ile Thr Ser Thr  Gln Val Ser Ser Ser  Pro Val Thr 
    3665                 3670                 3675             


Pro Glu  Gly Thr Thr Met Pro  Ile Trp Thr Pro Ser  Glu Gly Ser 
    3680                 3685                 3690             


Thr Pro  Leu Thr Thr Met Pro  Val Ser Thr Thr Arg  Val Thr Ser 
    3695                 3700                 3705             


Ser Glu  Gly Ser Thr Leu Ser  Thr Pro Ser Val Val  Thr Ser Thr 
    3710                 3715                 3720             


Pro Val  Thr Thr Ser Thr Glu  Ala Ile Ser Ser Ser  Ala Thr Leu 
    3725                 3730                 3735             


Asp Ser  Thr Thr Met Ser Val  Ser Met Pro Met Glu  Ile Ser Thr 
    3740                 3745                 3750             


Leu Gly  Thr Thr Ile Leu Val  Ser Thr Thr Pro Val  Thr Arg Phe 
    3755                 3760                 3765             


Pro Glu  Ser Ser Thr Pro Ser  Ile Pro Ser Val Tyr  Thr Ser Met 
    3770                 3775                 3780             


Ser Met  Thr Thr Ala Ser Glu  Gly Ser Ser Ser Pro  Thr Thr Leu 
    3785                 3790                 3795             


Glu Gly  Thr Thr Thr Met Pro  Met Ser Thr Thr Ser  Glu Arg Ser 
    3800                 3805                 3810             


Thr Leu  Leu Thr Thr Val Leu  Ile Ser Pro Ile Ser  Val Met Ser 
    3815                 3820                 3825             


Pro Ser  Glu Ala Ser Thr Leu  Ser Thr Pro Pro Gly  Asp Thr Ser 
    3830                 3835                 3840             


Thr Pro  Leu Leu Thr Ser Thr  Lys Ala Gly Ser Phe  Ser Ile Pro 
    3845                 3850                 3855             


Ala Glu  Val Thr Thr Ile Arg  Ile Ser Ile Thr Ser  Glu Arg Ser 
    3860                 3865                 3870             


Thr Pro  Leu Thr Thr Leu Leu  Val Ser Thr Thr Leu  Pro Thr Ser 
    3875                 3880                 3885             


Phe Pro  Gly Ala Ser Ile Ala  Ser Thr Pro Pro Leu  Asp Thr Ser 
    3890                 3895                 3900             


Thr Thr  Phe Thr Pro Ser Thr  Asp Thr Ala Ser Thr  Pro Thr Ile 
    3905                 3910                 3915             


Pro Val  Ala Thr Thr Ile Ser  Val Ser Val Ile Thr  Glu Gly Ser 
    3920                 3925                 3930             


Thr Pro  Gly Thr Thr Ile Phe  Ile Pro Ser Thr Pro  Val Thr Ser 
    3935                 3940                 3945             


Ser Thr  Ala Asp Val Phe Pro  Ala Thr Thr Gly Ala  Val Ser Thr 
    3950                 3955                 3960             


Pro Val  Ile Thr Ser Thr Glu  Leu Asn Thr Pro Ser  Thr Ser Ser 
    3965                 3970                 3975             


Ser Ser  Thr Thr Thr Ser Phe  Ser Thr Thr Lys Glu  Phe Thr Thr 
    3980                 3985                 3990             


Pro Ala  Met Thr Thr Ala Ala  Pro Leu Thr Tyr Val  Thr Met Ser 
    3995                 4000                 4005             


Thr Ala  Pro Ser Thr Pro Arg  Thr Thr Ser Arg Gly  Cys Thr Thr 
    4010                 4015                 4020             


Ser Ala  Ser Thr Leu Ser Ala  Thr Ser Thr Pro His  Thr Ser Thr 
    4025                 4030                 4035             


Ser Val  Thr Thr Arg Pro Val  Thr Pro Ser Ser Glu  Ser Ser Arg 
    4040                 4045                 4050             


Pro Ser  Thr Ile Thr Ser His  Thr Ile Pro Pro Thr  Phe Pro Pro 
    4055                 4060                 4065             


Ala His  Ser Ser Thr Pro Pro  Thr Thr Ser Ala Ser  Ser Thr Thr 
    4070                 4075                 4080             


Val Asn  Pro Glu Ala Val Thr  Thr Met Thr Thr Arg  Thr Lys Pro 
    4085                 4090                 4095             


Ser Thr  Arg Thr Thr Ser Phe  Pro Thr Val Thr Thr  Thr Ala Val 
    4100                 4105                 4110             


Pro Thr  Asn Thr Thr Ile Lys  Ser Asn Pro Thr Ser  Thr Pro Thr 
    4115                 4120                 4125             


Val Pro  Arg Thr Thr Thr Cys  Phe Gly Asp Gly Cys  Gln Asn Thr 
    4130                 4135                 4140             


Ala Ser  Arg Cys Lys Asn Gly  Gly Thr Trp Asp Gly  Leu Lys Cys 
    4145                 4150                 4155             


Gln Cys  Pro Asn Leu Tyr Tyr  Gly Glu Leu Cys Glu  Glu Val Val 
    4160                 4165                 4170             


Ser Ser  Ile Asp Ile Gly Pro  Pro Glu Thr Ile Ser  Ala Gln Met 
    4175                 4180                 4185             


Glu Leu  Thr Val Thr Val Thr  Ser Val Lys Phe Thr  Glu Glu Leu 
    4190                 4195                 4200             


Lys Asn  His Ser Ser Gln Glu  Phe Gln Glu Phe Lys  Gln Thr Phe 
    4205                 4210                 4215             


Thr Glu  Gln Met Asn Ile Val  Tyr Ser Gly Ile Pro  Glu Tyr Val 
    4220                 4225                 4230             


Gly Val  Asn Ile Thr Lys Leu  Arg Leu Gly Ser Val  Val Val Glu 
    4235                 4240                 4245             


His Asp  Val Leu Leu Arg Thr  Lys Tyr Thr Pro Glu  Tyr Lys Thr 
    4250                 4255                 4260             


Val Leu  Asp Asn Ala Thr Glu  Val Val Lys Glu Lys  Ile Thr Lys 
    4265                 4270                 4275             


Val Thr  Thr Gln Gln Ile Met  Ile Asn Asp Ile Cys  Ser Asp Met 
    4280                 4285                 4290             


Met Cys  Phe Asn Thr Thr Gly  Thr Gln Val Gln Asn  Ile Thr Val 
    4295                 4300                 4305             


Thr Gln  Tyr Asp Pro Glu Glu  Asp Cys Arg Lys Met  Ala Lys Glu 
    4310                 4315                 4320             


Tyr Gly  Asp Tyr Phe Val Val  Glu Tyr Arg Asp Gln  Lys Pro Tyr 
    4325                 4330                 4335             


Cys Ile  Ser Pro Cys Glu Pro  Gly Phe Ser Val Ser  Lys Asn Cys 
    4340                 4345                 4350             


Asn Leu  Gly Lys Cys Gln Met  Ser Leu Ser Gly Pro  Gln Cys Leu 
    4355                 4360                 4365             


Cys Val  Thr Thr Glu Thr His  Trp Tyr Ser Gly Glu  Thr Cys Asn 
    4370                 4375                 4380             


Gln Gly  Thr Gln Lys Ser Leu  Val Tyr Gly Leu Val  Gly Ala Gly 
    4385                 4390                 4395             


Val Val  Leu Met Leu Ile Ile  Leu Val Ala Leu Leu  Met Leu Val 
    4400                 4405                 4410             


Phe Arg  Ser Lys Arg Glu Val  Lys Arg Gln Lys Tyr  Arg Leu Ser 
    4415                 4420                 4425             


Gln Leu  Tyr Lys Trp Gln Glu  Glu Asp Ser Gly Pro  Ala Pro Gly 
    4430                 4435                 4440             


Thr Phe  Gln Asn Ile Gly Phe  Asp Ile Cys Gln Asp  Asp Asp Ser 
    4445                 4450                 4455             


Ile His  Leu Glu Ser Ile Tyr  Ser Asn Phe Gln Pro  Ser Leu Arg 
    4460                 4465                 4470             


His Ile  Asp Pro Glu Thr Lys  Ile Arg Ile Gln Arg  Pro Gln Val 
    4475                 4480                 4485             


Met Thr  Thr Ser Phe 
    4490             


<210>  39
<211>  3633
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (264)..(3395)

<400>  39
ctctcctggt ttgactggca cagggagcct gggctggaag aggcagcaaa agggaaaatc       60

agaagagtgg acactggcaa gaggagggca gcctttttcc cagcttcctt gcaccatgga      120

cagctcccat taagccacct ctccatcctg gggccaggac tcttatgccc cattcctgtc      180

aaattgagat ttcatccacc attctccaag gacagtgaag ttatacccta gttccagtgt      240

tgggatcagt ggcccctctg gac atg cct ctc ctg gaa ggt tct gtg ggg gtg      293
                          Met Pro Leu Leu Glu Gly Ser Val Gly Val         
                          1               5                   10          

gag gat ctt gtc ctc ctg gaa ccc ttg gtg gag gag tca ctg ctc aag        341
Glu Asp Leu Val Leu Leu Glu Pro Leu Val Glu Glu Ser Leu Leu Lys           
                15                  20                  25                

aat ctt cag ctt cgc tat gaa aac aag gag att tat acc tac att ggg        389
Asn Leu Gln Leu Arg Tyr Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly           
            30                  35                  40                    

aat gtg gtg atc tca gtg aat ccc tat caa cag ctt ccc atc tat ggg        437
Asn Val Val Ile Ser Val Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly           
        45                  50                  55                        

cca gag ttc att gcc aaa tat caa gac tat act ttc tat gag ctg aag        485
Pro Glu Phe Ile Ala Lys Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys           
    60                  65                  70                            

ccc cat atc tac gca ttg gca aat gtg gcg tac cag tca ctg agg gac        533
Pro His Ile Tyr Ala Leu Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp           
75                  80                  85                  90            

agg gac cga gac cag tgt atc ctc atc aca ggc gag agt gga tca ggg        581
Arg Asp Arg Asp Gln Cys Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly           
                95                  100                 105               

aag act gag gcc agc aag ctg gtg atg tct tat gtg gct gcc gtc tgt        629
Lys Thr Glu Ala Ser Lys Leu Val Met Ser Tyr Val Ala Ala Val Cys           
            110                 115                 120                   

ggg aaa gga gag cag gtg aac tct gtg aag gag cag ctg cta cag tct        677
Gly Lys Gly Glu Gln Val Asn Ser Val Lys Glu Gln Leu Leu Gln Ser           
        125                 130                 135                       

aac cca gtg ctg gag gct ttt ggc aat gcc aag acc att cgc aac aac        725
Asn Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn           
    140                 145                 150                           

aat tcc tcc cga ttt gga aaa tac atg gat att gaa ttt gac ttc aag        773
Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys           
155                 160                 165                 170           

gga tcc ccc ctc ggt ggt gtc atc aca aac tat ctg ctt gag aaa tcc        821
Gly Ser Pro Leu Gly Gly Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser           
                175                 180                 185               

cga tta gtg aag cag ctc aaa gga gaa agg aac ttc cac atc ttc tat        869
Arg Leu Val Lys Gln Leu Lys Gly Glu Arg Asn Phe His Ile Phe Tyr           
            190                 195                 200                   

cag ctg ctg gct gga gca gat gaa cag ctg ctg aag gcc ctg aag ctt        917
Gln Leu Leu Ala Gly Ala Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu           
        205                 210                 215                       

gag cgg gat aca act ggc tat gcc tat ctg aat cat gaa gta tcc aga        965
Glu Arg Asp Thr Thr Gly Tyr Ala Tyr Leu Asn His Glu Val Ser Arg           
    220                 225                 230                           

gtg gat ggc atg gac gac gcc tcc agc ttc agg gct gta cag agt gca       1013
Val Asp Gly Met Asp Asp Ala Ser Ser Phe Arg Ala Val Gln Ser Ala           
235                 240                 245                 250           

atg gca gtg att ggg ttc tcg gag gag gag att cga caa gtg cta gag       1061
Met Ala Val Ile Gly Phe Ser Glu Glu Glu Ile Arg Gln Val Leu Glu           
                255                 260                 265               

gtg aca tcc atg gtg cta aag ctg ggg aac gtg ttg gtg gct gat gag       1109
Val Thr Ser Met Val Leu Lys Leu Gly Asn Val Leu Val Ala Asp Glu           
            270                 275                 280                   

ttc cag gcc agt ggg ata cca gca agt ggc atc cgt gat ggg aga ggt       1157
Phe Gln Ala Ser Gly Ile Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly           
        285                 290                 295                       

gtt cgg gag att ggg gag atg gtg ggc ttg aat tca gaa gaa gta gag       1205
Val Arg Glu Ile Gly Glu Met Val Gly Leu Asn Ser Glu Glu Val Glu           
    300                 305                 310                           

aga gct ttg tgc tcg agg acc atg gaa aca gcc aag gaa aag gtg gtc       1253
Arg Ala Leu Cys Ser Arg Thr Met Glu Thr Ala Lys Glu Lys Val Val           
315                 320                 325                 330           

act gca ctg aat gtt atg cag gct cag tat gct cgg gac gcc ctg gct       1301
Thr Ala Leu Asn Val Met Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala           
                335                 340                 345               

aag aac atc tac agc cgc ctc ttt gac tgg ata gtg aat cga atc aat       1349
Lys Asn Ile Tyr Ser Arg Leu Phe Asp Trp Ile Val Asn Arg Ile Asn           
            350                 355                 360                   

gag agc atc aag gtg ggc atc ggg gaa aag aag aag gta atg gga gtc       1397
Glu Ser Ile Lys Val Gly Ile Gly Glu Lys Lys Lys Val Met Gly Val           
        365                 370                 375                       

ctt gat atc tac ggt ttt gag ata tta gag gat aat agc ttt gag caa       1445
Leu Asp Ile Tyr Gly Phe Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln           
    380                 385                 390                           

ttt gtg atc aac tac tgc aat gag aag ctg cag cag gtg ttc ata gag       1493
Phe Val Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Val Phe Ile Glu           
395                 400                 405                 410           

atg acc ctg aaa gaa gag caa gag gaa tat aag aga gaa ggc ata ccg       1541
Met Thr Leu Lys Glu Glu Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro           
                415                 420                 425               

tgg aca aag gtg gac tac ttt gat aat ggc atc att tgt aag ctc att       1589
Trp Thr Lys Val Asp Tyr Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile           
            430                 435                 440                   

gag cat aat cag cga ggt atc ctg gcc atg ttg gat gag gag tgc ctg       1637
Glu His Asn Gln Arg Gly Ile Leu Ala Met Leu Asp Glu Glu Cys Leu           
        445                 450                 455                       

cgg cct ggg gtg gtc agt gac tcc act ttc cta gca aag ctg aac cag       1685
Arg Pro Gly Val Val Ser Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln           
    460                 465                 470                           

ctc ttc tcc aag cat ggc cac tac gag agc aaa gtc acc cag aat gcc       1733
Leu Phe Ser Lys His Gly His Tyr Glu Ser Lys Val Thr Gln Asn Ala           
475                 480                 485                 490           

cag cgt cag tat gac cac acc atg ggc ctc agc tgc ttc cgc atc tgc       1781
Gln Arg Gln Tyr Asp His Thr Met Gly Leu Ser Cys Phe Arg Ile Cys           
                495                 500                 505               

cac tat gcg ggc aag gtg aca tac aac gtg acc agc ttt att gac aag       1829
His Tyr Ala Gly Lys Val Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys           
            510                 515                 520                   

aat aat gac cta ctc ttc cga gac ctg ttg cag gcc atg tgg aag gcc       1877
Asn Asn Asp Leu Leu Phe Arg Asp Leu Leu Gln Ala Met Trp Lys Ala           
        525                 530                 535                       

cag cac ccc ctc ctt cgg tcc ttg ttt cct gag ggc aat cct aag cag       1925
Gln His Pro Leu Leu Arg Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln           
    540                 545                 550                           

gca tct ctc aaa cgc ccc ccg act gct ggg gcc cag ttc aag agt tct       1973
Ala Ser Leu Lys Arg Pro Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser           
555                 560                 565                 570           

gtg gcc atc ctc atg aag aat ctg tat tcc aag agc ccc aac tac atc       2021
Val Ala Ile Leu Met Lys Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile           
                575                 580                 585               

agg tgc ata aag ccc aat gag cat cag cag cga ggt cag ttc tct tca       2069
Arg Cys Ile Lys Pro Asn Glu His Gln Gln Arg Gly Gln Phe Ser Ser           
            590                 595                 600                   

gac ctg gtg gca acc cag gct cgg tac ctg gga ctg ctg gag aac gta       2117
Asp Leu Val Ala Thr Gln Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val           
        605                 610                 615                       

cgg gtg cga cgg gca ggc tat gcc cac cgc cag ggt tat ggg ccc ttc       2165
Arg Val Arg Arg Ala Gly Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe           
    620                 625                 630                           

ctg gaa agg tac cga ttg ctg agc cgg agc acc tgg cct cac tgg aat       2213
Leu Glu Arg Tyr Arg Leu Leu Ser Arg Ser Thr Trp Pro His Trp Asn           
635                 640                 645                 650           

ggg gga gac cgg gaa ggt gtt gag aag gtc ctg ggg gag ctg agc atg       2261
Gly Gly Asp Arg Glu Gly Val Glu Lys Val Leu Gly Glu Leu Ser Met           
                655                 660                 665               

tcc tcg ggg gag ctg gcc ttt ggc aag aca aag atc ttc att aga agc       2309
Ser Ser Gly Glu Leu Ala Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser           
            670                 675                 680                   

ccc aag act ctt ttc tac ctc gaa gaa cag agg cgc ctg aga ctc cag       2357
Pro Lys Thr Leu Phe Tyr Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln           
        685                 690                 695                       

cag ctg gcc aca ctc ata cag aag att tac cga ggc tgg cgc tgc cgc       2405
Gln Leu Ala Thr Leu Ile Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg           
    700                 705                 710                           

acc cac tac caa ctg atg cga aag agt cag atc ctc atc tcc tct tgg       2453
Thr His Tyr Gln Leu Met Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp           
715                 720                 725                 730           

ttt cgg gga aac atg caa aag aaa tgc tat ggg aag ata aag gca tcc       2501
Phe Arg Gly Asn Met Gln Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser           
                735                 740                 745               

gtg tta ttg atc cag gct ttt gtg aga ggg tgg aag gcc cga aag aat       2549
Val Leu Leu Ile Gln Ala Phe Val Arg Gly Trp Lys Ala Arg Lys Asn           
            750                 755                 760                   

tat cgc aaa tat ttc cgg tca gag gct gcc ctc acc ttg gca gat ttc       2597
Tyr Arg Lys Tyr Phe Arg Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe           
        765                 770                 775                       

atc tac aag agc atg gta cag aaa ttc cta ctg ggg ctg aag aac aat       2645
Ile Tyr Lys Ser Met Val Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn           
    780                 785                 790                           

ttg cca tcc aca aac gtc tta gac aag aca tgg cca gcc gcc ccc tac       2693
Leu Pro Ser Thr Asn Val Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr           
795                 800                 805                 810           

aag tgc ctc agc aca gca aat cag gag ctg cag cag ctc ttc tac cag       2741
Lys Cys Leu Ser Thr Ala Asn Gln Glu Leu Gln Gln Leu Phe Tyr Gln           
                815                 820                 825               

tgg aag tgc aag agg ttc cgg gat cag ctg tcc ccg aag cag gta gag       2789
Trp Lys Cys Lys Arg Phe Arg Asp Gln Leu Ser Pro Lys Gln Val Glu           
            830                 835                 840                   

atc ctg agg gaa aag ctc tgt gcc agt gaa ctg ttc aag ggc aag aag       2837
Ile Leu Arg Glu Lys Leu Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys           
        845                 850                 855                       

gct tca tat ccc cag agt gtc ccc att cca ttc tgt ggt gac tac att       2885
Ala Ser Tyr Pro Gln Ser Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile           
    860                 865                 870                           

ggg ctg caa ggg aac ccc aag ctg cag aag ctg aaa ggc ggg gag gag       2933
Gly Leu Gln Gly Asn Pro Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu           
875                 880                 885                 890           

ggg cct gtt ctg atg gca gag gcc gtg aag aag gtc aat cgt ggc aat       2981
Gly Pro Val Leu Met Ala Glu Ala Val Lys Lys Val Asn Arg Gly Asn           
                895                 900                 905               

ggc aag act tct tct cgg att ctc ctc ctg acc aag ggc cat gtg att       3029
Gly Lys Thr Ser Ser Arg Ile Leu Leu Leu Thr Lys Gly His Val Ile           
            910                 915                 920                   

ctc aca gac acc aag aag tcc cag gcc aaa att gtc att ggg cta gac       3077
Leu Thr Asp Thr Lys Lys Ser Gln Ala Lys Ile Val Ile Gly Leu Asp           
        925                 930                 935                       

aat gtg gct ggg gtg tca gtc acc agc ctc aag gat ggg ctc ttt agc       3125
Asn Val Ala Gly Val Ser Val Thr Ser Leu Lys Asp Gly Leu Phe Ser           
    940                 945                 950                           

ttg cat ctg agt gag atg tca tcg gtg ggc tcc aag ggg gac ttc ctg       3173
Leu His Leu Ser Glu Met Ser Ser Val Gly Ser Lys Gly Asp Phe Leu           
955                 960                 965                 970           

ctg gtc agc gag cat gtg att gaa ctg ctg acc aaa atg tac cgg gct       3221
Leu Val Ser Glu His Val Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala           
                975                 980                 985               

gtg ctg gat gcc acg cag agg cag ctt aca gtc acc gtg act  gag aag      3269
Val Leu Asp Ala Thr Gln Arg Gln Leu Thr Val Thr Val Thr  Glu Lys          
            990                 995                 1000                  

ttc tca gtg  agg ttc aag gag aac  agt gtg gct gtc aag  gtc gtc        3314
Phe Ser Val  Arg Phe Lys Glu Asn  Ser Val Ala Val Lys  Val Val            
        1005                 1010                 1015                    

cag ggc cct  gca ggt ggt gac aac  agc aag cta cgc tac  aaa aaa        3359
Gln Gly Pro  Ala Gly Gly Asp Asn  Ser Lys Leu Arg Tyr  Lys Lys            
        1020                 1025                 1030                    

aag ggg agt  cat tgc ttg gag gtg  act gtg cag tga ggagggggca          3405
Lys Gly Ser  His Cys Leu Glu Val  Thr Val Gln                             
        1035                 1040                                         

ccatgcagag atggcagttg cttcctcctg aaccagcact aatccccctc tgccctcctg     3465

tgtgggagga tctctaaccc ctctgatcgt ggcgcatggc ttggggatta aactaccctt     3525

gaagaggacc cttgtcccaa acccttcttg ttctctcctc caaaagtagc ttcctccaac     3585

ccgcagcctc tctgcacact aataaaacat gtggcttgga aaggttca                  3633


<210>  40
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Leu Leu Glu Gly Ser Val Gly Val Glu Asp Leu Val Leu Leu 
1               5                   10                  15      


Glu Pro Leu Val Glu Glu Ser Leu Leu Lys Asn Leu Gln Leu Arg Tyr 
            20                  25                  30          


Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly Asn Val Val Ile Ser Val 
        35                  40                  45              


Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly Pro Glu Phe Ile Ala Lys 
    50                  55                  60                  


Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys Pro His Ile Tyr Ala Leu 
65                  70                  75                  80  


Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp Arg Asp Arg Asp Gln Cys 
                85                  90                  95      


Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Ser Lys 
            100                 105                 110         


Leu Val Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly Glu Gln Val 
        115                 120                 125             


Asn Ser Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala 
    130                 135                 140                 


Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn Asn Ser Ser Arg Phe Gly 
145                 150                 155                 160 


Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys Gly Ser Pro Leu Gly Gly 
                165                 170                 175     


Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser Arg Leu Val Lys Gln Leu 
            180                 185                 190         


Lys Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu Leu Ala Gly Ala 
        195                 200                 205             


Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu Glu Arg Asp Thr Thr Gly 
    210                 215                 220                 


Tyr Ala Tyr Leu Asn His Glu Val Ser Arg Val Asp Gly Met Asp Asp 
225                 230                 235                 240 


Ala Ser Ser Phe Arg Ala Val Gln Ser Ala Met Ala Val Ile Gly Phe 
                245                 250                 255     


Ser Glu Glu Glu Ile Arg Gln Val Leu Glu Val Thr Ser Met Val Leu 
            260                 265                 270         


Lys Leu Gly Asn Val Leu Val Ala Asp Glu Phe Gln Ala Ser Gly Ile 
        275                 280                 285             


Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly Val Arg Glu Ile Gly Glu 
    290                 295                 300                 


Met Val Gly Leu Asn Ser Glu Glu Val Glu Arg Ala Leu Cys Ser Arg 
305                 310                 315                 320 


Thr Met Glu Thr Ala Lys Glu Lys Val Val Thr Ala Leu Asn Val Met 
                325                 330                 335     


Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala Lys Asn Ile Tyr Ser Arg 
            340                 345                 350         


Leu Phe Asp Trp Ile Val Asn Arg Ile Asn Glu Ser Ile Lys Val Gly 
        355                 360                 365             


Ile Gly Glu Lys Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe 
    370                 375                 380                 


Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln Phe Val Ile Asn Tyr Cys 
385                 390                 395                 400 


Asn Glu Lys Leu Gln Gln Val Phe Ile Glu Met Thr Leu Lys Glu Glu 
                405                 410                 415     


Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro Trp Thr Lys Val Asp Tyr 
            420                 425                 430         


Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile Glu His Asn Gln Arg Gly 
        435                 440                 445             


Ile Leu Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Val Val Ser 
    450                 455                 460                 


Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln Leu Phe Ser Lys His Gly 
465                 470                 475                 480 


His Tyr Glu Ser Lys Val Thr Gln Asn Ala Gln Arg Gln Tyr Asp His 
                485                 490                 495     


Thr Met Gly Leu Ser Cys Phe Arg Ile Cys His Tyr Ala Gly Lys Val 
            500                 505                 510         


Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys Asn Asn Asp Leu Leu Phe 
        515                 520                 525             


Arg Asp Leu Leu Gln Ala Met Trp Lys Ala Gln His Pro Leu Leu Arg 
    530                 535                 540                 


Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln Ala Ser Leu Lys Arg Pro 
545                 550                 555                 560 


Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser Val Ala Ile Leu Met Lys 
                565                 570                 575     


Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn 
            580                 585                 590         


Glu His Gln Gln Arg Gly Gln Phe Ser Ser Asp Leu Val Ala Thr Gln 
        595                 600                 605             


Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly 
    610                 615                 620                 


Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe Leu Glu Arg Tyr Arg Leu 
625                 630                 635                 640 


Leu Ser Arg Ser Thr Trp Pro His Trp Asn Gly Gly Asp Arg Glu Gly 
                645                 650                 655     


Val Glu Lys Val Leu Gly Glu Leu Ser Met Ser Ser Gly Glu Leu Ala 
            660                 665                 670         


Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser Pro Lys Thr Leu Phe Tyr 
        675                 680                 685             


Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln Gln Leu Ala Thr Leu Ile 
    690                 695                 700                 


Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg Thr His Tyr Gln Leu Met 
705                 710                 715                 720 


Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp Phe Arg Gly Asn Met Gln 
                725                 730                 735     


Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser Val Leu Leu Ile Gln Ala 
            740                 745                 750         


Phe Val Arg Gly Trp Lys Ala Arg Lys Asn Tyr Arg Lys Tyr Phe Arg 
        755                 760                 765             


Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe Ile Tyr Lys Ser Met Val 
    770                 775                 780                 


Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn Leu Pro Ser Thr Asn Val 
785                 790                 795                 800 


Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr Lys Cys Leu Ser Thr Ala 
                805                 810                 815     


Asn Gln Glu Leu Gln Gln Leu Phe Tyr Gln Trp Lys Cys Lys Arg Phe 
            820                 825                 830         


Arg Asp Gln Leu Ser Pro Lys Gln Val Glu Ile Leu Arg Glu Lys Leu 
        835                 840                 845             


Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys Ala Ser Tyr Pro Gln Ser 
    850                 855                 860                 


Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile Gly Leu Gln Gly Asn Pro 
865                 870                 875                 880 


Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu Gly Pro Val Leu Met Ala 
                885                 890                 895     


Glu Ala Val Lys Lys Val Asn Arg Gly Asn Gly Lys Thr Ser Ser Arg 
            900                 905                 910         


Ile Leu Leu Leu Thr Lys Gly His Val Ile Leu Thr Asp Thr Lys Lys 
        915                 920                 925             


Ser Gln Ala Lys Ile Val Ile Gly Leu Asp Asn Val Ala Gly Val Ser 
    930                 935                 940                 


Val Thr Ser Leu Lys Asp Gly Leu Phe Ser Leu His Leu Ser Glu Met 
945                 950                 955                 960 


Ser Ser Val Gly Ser Lys Gly Asp Phe Leu Leu Val Ser Glu His Val 
                965                 970                 975     


Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala Val Leu Asp Ala Thr Gln 
            980                 985                 990         


Arg Gln Leu Thr Val Thr Val Thr  Glu Lys Phe Ser Val  Arg Phe Lys 
        995                 1000                 1005             


Glu Asn  Ser Val Ala Val Lys  Val Val Gln Gly Pro  Ala Gly Gly 
    1010                 1015                 1020             


Asp Asn  Ser Lys Leu Arg Tyr  Lys Lys Lys Gly Ser  His Cys Leu 
    1025                 1030                 1035             


Glu Val  Thr Val Gln 
    1040             


<210>  41
<211>  2772
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (49)..(1470)

<400>  41
ggcctgctgg gttagtgctg gcagccccct gaggccaagg acagcagc atg aca gtc        57
                                                     Met Thr Val          
                                                     1                    

acc agg act cac cac ttc aag gag ggg tcc ctc aga gca cct gcc ata        105
Thr Arg Thr His His Phe Lys Glu Gly Ser Leu Arg Ala Pro Ala Ile           
    5                   10                  15                            

ccc ctg cac agt gct gcg gct gag ttg gct tca aac cat cca aga ggc        153
Pro Leu His Ser Ala Ala Ala Glu Leu Ala Ser Asn His Pro Arg Gly           
20                  25                  30                  35            

cca gaa gca aac ctg gag gtg aga ccc aaa gaa agc tgg aac cat gct        201
Pro Glu Ala Asn Leu Glu Val Arg Pro Lys Glu Ser Trp Asn His Ala           
                40                  45                  50                

gac ttt gta cac tgt gag gac aca gag tct gtt cct gga aag ccc agt        249
Asp Phe Val His Cys Glu Asp Thr Glu Ser Val Pro Gly Lys Pro Ser           
            55                  60                  65                    

gtc aac gca gat gag gaa gtc gga ggt ccc caa atc tgc cgt gta tgt        297
Val Asn Ala Asp Glu Glu Val Gly Gly Pro Gln Ile Cys Arg Val Cys           
        70                  75                  80                        

ggg gac aag gcc act ggc tat cac ttc aat gtc atg aca tgt gaa gga        345
Gly Asp Lys Ala Thr Gly Tyr His Phe Asn Val Met Thr Cys Glu Gly           
    85                  90                  95                            

tgc aag ggc ttt ttc agg agg gcc atg aaa cgc aac gcc cgg ctg agg        393
Cys Lys Gly Phe Phe Arg Arg Ala Met Lys Arg Asn Ala Arg Leu Arg           
100                 105                 110                 115           

tgc ccc ttc cgg aag ggc gcc tgc gag atc acc cgg aag acc cgg cga        441
Cys Pro Phe Arg Lys Gly Ala Cys Glu Ile Thr Arg Lys Thr Arg Arg           
                120                 125                 130               

cag tgc cag gcc tgc cgc ctg cgc aag tgc ctg gag agc ggc atg aag        489
Gln Cys Gln Ala Cys Arg Leu Arg Lys Cys Leu Glu Ser Gly Met Lys           
            135                 140                 145                   

aag gag atg atc atg tcc gac gag gcc gtg gag gag agg cgg gcc ttg        537
Lys Glu Met Ile Met Ser Asp Glu Ala Val Glu Glu Arg Arg Ala Leu           
        150                 155                 160                       

atc aag cgg aag aaa agt gaa cgg aca ggg act cag cca ctg gga gtg        585
Ile Lys Arg Lys Lys Ser Glu Arg Thr Gly Thr Gln Pro Leu Gly Val           
    165                 170                 175                           

cag ggg ctg aca gag gag cag cgg atg atg atc agg gag ctg atg gac        633
Gln Gly Leu Thr Glu Glu Gln Arg Met Met Ile Arg Glu Leu Met Asp           
180                 185                 190                 195           

gct cag atg aaa acc ttt gac act acc ttc tcc cat ttc aag aat ttc        681
Ala Gln Met Lys Thr Phe Asp Thr Thr Phe Ser His Phe Lys Asn Phe           
                200                 205                 210               

cgg ctg cca ggg gtg ctt agc agt ggc tgc gag ttg cca gag tct ctg        729
Arg Leu Pro Gly Val Leu Ser Ser Gly Cys Glu Leu Pro Glu Ser Leu           
            215                 220                 225                   

cag gcc cca tcg agg gaa gaa gct gcc aag tgg agc cag gtc cgg aaa        777
Gln Ala Pro Ser Arg Glu Glu Ala Ala Lys Trp Ser Gln Val Arg Lys           
        230                 235                 240                       

gat ctg tgc tct ttg aag gtc tct ctg cag ctg cgg ggg gag gat ggc        825
Asp Leu Cys Ser Leu Lys Val Ser Leu Gln Leu Arg Gly Glu Asp Gly           
    245                 250                 255                           

agt gtc tgg aac tac aaa ccc cca gcc gac agt ggc ggg aaa gag atc        873
Ser Val Trp Asn Tyr Lys Pro Pro Ala Asp Ser Gly Gly Lys Glu Ile           
260                 265                 270                 275           

ttc tcc ctg ctg ccc cac atg gct gac atg tca acc tac atg ttc aaa        921
Phe Ser Leu Leu Pro His Met Ala Asp Met Ser Thr Tyr Met Phe Lys           
                280                 285                 290               

ggc atc atc agc ttt gcc aaa gtc atc tcc tac ttc agg gac ttg ccc        969
Gly Ile Ile Ser Phe Ala Lys Val Ile Ser Tyr Phe Arg Asp Leu Pro           
            295                 300                 305                   

atc gag gac cag atc tcc ctg ctg aag ggg gcc gct ttc gag ctg tgt       1017
Ile Glu Asp Gln Ile Ser Leu Leu Lys Gly Ala Ala Phe Glu Leu Cys           
        310                 315                 320                       

caa ctg aga ttc aac aca gtg ttc aac gcg gag act gga acc tgg gag       1065
Gln Leu Arg Phe Asn Thr Val Phe Asn Ala Glu Thr Gly Thr Trp Glu           
    325                 330                 335                           

tgt ggc cgg ctg tcc tac tgc ttg gaa gac act gca ggt ggc ttc cag       1113
Cys Gly Arg Leu Ser Tyr Cys Leu Glu Asp Thr Ala Gly Gly Phe Gln           
340                 345                 350                 355           

caa ctt cta ctg gag ccc atg ctg aaa ttc cac tac atg ctg aag aag       1161
Gln Leu Leu Leu Glu Pro Met Leu Lys Phe His Tyr Met Leu Lys Lys           
                360                 365                 370               

ctg cag ctg cat gag gag gag tat gtg ctg atg cag gcc atc tcc ctc       1209
Leu Gln Leu His Glu Glu Glu Tyr Val Leu Met Gln Ala Ile Ser Leu           
            375                 380                 385                   

ttc tcc cca gac cgc cca ggt gtg ctg cag cac cgc gtg gtg gac cag       1257
Phe Ser Pro Asp Arg Pro Gly Val Leu Gln His Arg Val Val Asp Gln           
        390                 395                 400                       

ctg cag gag caa ttc gcc att act ctg aag tcc tac att gaa tgc aat       1305
Leu Gln Glu Gln Phe Ala Ile Thr Leu Lys Ser Tyr Ile Glu Cys Asn           
    405                 410                 415                           

cgg ccc cag cct gct cat agg ttc ttg ttc ctg aag atc atg gct atg       1353
Arg Pro Gln Pro Ala His Arg Phe Leu Phe Leu Lys Ile Met Ala Met           
420                 425                 430                 435           

ctc acc gag ctc cgc agc atc aat gct cag cac acc cag cgg ctg ctg       1401
Leu Thr Glu Leu Arg Ser Ile Asn Ala Gln His Thr Gln Arg Leu Leu           
                440                 445                 450               

cgc atc cag gac ata cac ccc ttt gct acg ccc ctc atg cag gag ttg       1449
Arg Ile Gln Asp Ile His Pro Phe Ala Thr Pro Leu Met Gln Glu Leu           
            455                 460                 465                   

ttc ggc atc aca ggt agc tga gcggctgccc ttgggtgaca cctccgagag          1500
Phe Gly Ile Thr Gly Ser                                                   
        470                                                               

gcagccagac ccagagccct ctgagccgcc actcccgggc caagacagat ggacactgcc     1560

aagagccgac aatgccctgc tggcctgtct ccctagggaa ttcctgctat gacagctggc     1620

tagcattcct caggaaggac atgggtgccc cccaccccca gttcagtctg tagggagtga     1680

agccacagac tcttacgtgg agagtgcact gacctgtagg tcaggaccat cagagaggca     1740

aggttgccct ttccttttaa aaggccctgt ggtctgggga gaaatccctc agatcccact     1800

aaagtgtcaa ggtgtggaag ggaccaagcg accaaggatg ggccatctgg ggtctatgcc     1860

cacataccca cgtttgttcg cttcctgagt cttttcattg ctacctctaa tagtcctgtc     1920

tcccacttcc cactcgttcc cctcctcttc cgagctgctt tgtgggctcc aggcctgtac     1980

tcatcggcag gcgcatgagt atctgtggga gtcctctaga gagatgagaa gccaggaggc     2040

ctgcaccaaa tgtcagaagc ttggcatgac ctcattccgg ccacatcatt ctgtgtctct     2100

gcatccattt gaacacatta ttaagcaccg ataataggta gcctgctgtg gggtatacag     2160

cattgactca gatatagatc ctgagctcac agagtttata gttaaaaaaa caaacagaaa     2220

cacaaacaat ttggatcaaa aggagaaatg ataagtgaca aaagcagcac aaggaatttc     2280

cctgtgtgga tgctgagctg tgatggcggg cactgggtac ccaagtgaag gttcccgagg     2340

acatgagtct gtaggagcaa gggcacaaac tgcagctgtg agtgcgtgtg tgtgatttgg     2400

tgtaggtagg tctgtttgcc acttgatggg gcctgggttt gttcctgggg ctggaatgct     2460

gggtatgctc tgtgacaagg ctacgctgac aatcagttaa acacaccgga gaagaaccat     2520

ttacatgcac cttatatttc tgtgtacaca tctattctca aagctaaagg gtatgaaagt     2580

gcctgccttg tttatagcca cttgtgagta aaaatttttt tgcattttca caaattatac     2640

tttatataag gcattccaca cctaagaact agttttggga aatgtagccc tgggtttaat     2700

gtcaaatcaa ggcaaaagga attaaataat gtacttttgg ctaaaaaaaa aaaaaaaaaa     2760

aaaaaaaaaa aa                                                         2772


<210>  42
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Thr Val Thr Arg Thr His His Phe Lys Glu Gly Ser Leu Arg Ala 
1               5                   10                  15      


Pro Ala Ile Pro Leu His Ser Ala Ala Ala Glu Leu Ala Ser Asn His 
            20                  25                  30          


Pro Arg Gly Pro Glu Ala Asn Leu Glu Val Arg Pro Lys Glu Ser Trp 
        35                  40                  45              


Asn His Ala Asp Phe Val His Cys Glu Asp Thr Glu Ser Val Pro Gly 
    50                  55                  60                  


Lys Pro Ser Val Asn Ala Asp Glu Glu Val Gly Gly Pro Gln Ile Cys 
65                  70                  75                  80  


Arg Val Cys Gly Asp Lys Ala Thr Gly Tyr His Phe Asn Val Met Thr 
                85                  90                  95      


Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ala Met Lys Arg Asn Ala 
            100                 105                 110         


Arg Leu Arg Cys Pro Phe Arg Lys Gly Ala Cys Glu Ile Thr Arg Lys 
        115                 120                 125             


Thr Arg Arg Gln Cys Gln Ala Cys Arg Leu Arg Lys Cys Leu Glu Ser 
    130                 135                 140                 


Gly Met Lys Lys Glu Met Ile Met Ser Asp Glu Ala Val Glu Glu Arg 
145                 150                 155                 160 


Arg Ala Leu Ile Lys Arg Lys Lys Ser Glu Arg Thr Gly Thr Gln Pro 
                165                 170                 175     


Leu Gly Val Gln Gly Leu Thr Glu Glu Gln Arg Met Met Ile Arg Glu 
            180                 185                 190         


Leu Met Asp Ala Gln Met Lys Thr Phe Asp Thr Thr Phe Ser His Phe 
        195                 200                 205             


Lys Asn Phe Arg Leu Pro Gly Val Leu Ser Ser Gly Cys Glu Leu Pro 
    210                 215                 220                 


Glu Ser Leu Gln Ala Pro Ser Arg Glu Glu Ala Ala Lys Trp Ser Gln 
225                 230                 235                 240 


Val Arg Lys Asp Leu Cys Ser Leu Lys Val Ser Leu Gln Leu Arg Gly 
                245                 250                 255     


Glu Asp Gly Ser Val Trp Asn Tyr Lys Pro Pro Ala Asp Ser Gly Gly 
            260                 265                 270         


Lys Glu Ile Phe Ser Leu Leu Pro His Met Ala Asp Met Ser Thr Tyr 
        275                 280                 285             


Met Phe Lys Gly Ile Ile Ser Phe Ala Lys Val Ile Ser Tyr Phe Arg 
    290                 295                 300                 


Asp Leu Pro Ile Glu Asp Gln Ile Ser Leu Leu Lys Gly Ala Ala Phe 
305                 310                 315                 320 


Glu Leu Cys Gln Leu Arg Phe Asn Thr Val Phe Asn Ala Glu Thr Gly 
                325                 330                 335     


Thr Trp Glu Cys Gly Arg Leu Ser Tyr Cys Leu Glu Asp Thr Ala Gly 
            340                 345                 350         


Gly Phe Gln Gln Leu Leu Leu Glu Pro Met Leu Lys Phe His Tyr Met 
        355                 360                 365             


Leu Lys Lys Leu Gln Leu His Glu Glu Glu Tyr Val Leu Met Gln Ala 
    370                 375                 380                 


Ile Ser Leu Phe Ser Pro Asp Arg Pro Gly Val Leu Gln His Arg Val 
385                 390                 395                 400 


Val Asp Gln Leu Gln Glu Gln Phe Ala Ile Thr Leu Lys Ser Tyr Ile 
                405                 410                 415     


Glu Cys Asn Arg Pro Gln Pro Ala His Arg Phe Leu Phe Leu Lys Ile 
            420                 425                 430         


Met Ala Met Leu Thr Glu Leu Arg Ser Ile Asn Ala Gln His Thr Gln 
        435                 440                 445             


Arg Leu Leu Arg Ile Gln Asp Ile His Pro Phe Ala Thr Pro Leu Met 
    450                 455                 460                 


Gln Glu Leu Phe Gly Ile Thr Gly Ser 
465                 470             


<210>  43
<211>  3115
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (766)..(2388)

<400>  43
ctctctgcgc ctcgctccga ctccggcgcg caccaagcgg gaacccgcgc ccgagcccgg       60

cgggcgccgc tgctgctcct ctcggtcccc ggttcccggt ccccgaacgc gccgcggcga      120

ggctgcgccc ggcagtggag ccgctcggag ctgctgggct ttggcggccg ctcgctgctc      180

cgtctggccg gaggaccggc ggggaaggaa ggggaaagcg gggacacaca cactcgccgc      240

ggcgcgcgcg cactgcacac tcgtagccgc gcgcccccgc caaggcgcgt ccggagcgag      300

tttggccccg cggctccagc cccggcacct gcccgccctc agcgttgccc ccggccccgg      360

ccccgcccgc cgccccctcc gccctcccgc ccctcccgcc cctcccgccc ctcgcctgca      420

ctgctctccc ttcgctgtgg ggaagcgaca acgtcccgat aacttgcaga ctgtggcgca      480

actggtcttg gtagcggagg cacccgaatg ctgcccgggt gagatgagga agccaaggcc      540

cagcagagct gagatgtgac tgcagagccg tccaacccca gtcctgtgac ctttctctgg      600

tgcctgatac ctctcagcat ttgagggcct tttctcttcc tgcttcatct ctaaaggtcc      660

ttctaggaga gaggtgaaag aaacctggca aagaaaacgg tctcgacaat gagtaggcca      720

cccatcacta ctaactacag atgacttgcc atttcattta caaag atg tct tct gct      777
                                                  Met Ser Ser Ala         
                                                  1                       

gct gaa aat gga gag gca gca cct gga aaa caa aat gaa gaa aaa acc        825
Ala Glu Asn Gly Glu Ala Ala Pro Gly Lys Gln Asn Glu Glu Lys Thr           
5                   10                  15                  20            

tat aaa aag act gca tca tct gct att aaa ggt gct att cag ctg gga        873
Tyr Lys Lys Thr Ala Ser Ser Ala Ile Lys Gly Ala Ile Gln Leu Gly           
                25                  30                  35                

ata gga tac aca gtg ggt aat ctc act tcc aag cca gaa cga gat gtt        921
Ile Gly Tyr Thr Val Gly Asn Leu Thr Ser Lys Pro Glu Arg Asp Val           
            40                  45                  50                    

ctt atg caa gac ttt tat gtg gtg gaa agt gtg ttc cta ccc agc gaa        969
Leu Met Gln Asp Phe Tyr Val Val Glu Ser Val Phe Leu Pro Ser Glu           
        55                  60                  65                        

ggg agc aat ctg acc cca gca cat cac tac cca gac ttt aga ttt aag       1017
Gly Ser Asn Leu Thr Pro Ala His His Tyr Pro Asp Phe Arg Phe Lys           
    70                  75                  80                            

aca tac gct cca tta gca ttc cga tat ttc aga gaa ctt ttt ggt atc       1065
Thr Tyr Ala Pro Leu Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile           
85                  90                  95                  100           

aag cct gat gat tac ttg tat tcc atc tgc agt gaa cct cta ata gaa       1113
Lys Pro Asp Asp Tyr Leu Tyr Ser Ile Cys Ser Glu Pro Leu Ile Glu           
                105                 110                 115               

ctg tct aac cct gga gcc agt gga tcc ttg ttt ttt gtg acc agt gat       1161
Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu Phe Phe Val Thr Ser Asp           
            120                 125                 130                   

gat gaa ttt atc atc aaa aca gtt cag cac aaa gaa gct gag ttt ctt       1209
Asp Glu Phe Ile Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu           
        135                 140                 145                       

cag aag cta ctg cca ggc tat tac atg aat tta aac cag aat cca agg       1257
Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg           
    150                 155                 160                           

act ctt ttg cca aaa ttt tac gga ctg tat tgt atg caa tca gga ggc       1305
Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr Cys Met Gln Ser Gly Gly           
165                 170                 175                 180           

att aat atc agg att gtg gtg atg aac aac gtt ttg cca cgc tcc atg       1353
Ile Asn Ile Arg Ile Val Val Met Asn Asn Val Leu Pro Arg Ser Met           
                185                 190                 195               

aga atg cac ttt aca tat gac ttg aaa ggc tca acg tat aag cga aga       1401
Arg Met His Phe Thr Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg           
            200                 205                 210                   

gca tcc cgt aaa gag aga gag aaa tcc aac ccc aca ttt aag gac tta       1449
Ala Ser Arg Lys Glu Arg Glu Lys Ser Asn Pro Thr Phe Lys Asp Leu           
        215                 220                 225                       

gat ttc ctg caa gac atg cac gaa ggg ttg tat ttt gat acg gaa aca       1497
Asp Phe Leu Gln Asp Met His Glu Gly Leu Tyr Phe Asp Thr Glu Thr           
    230                 235                 240                           

tac aac gcg ctt atg aaa aca ctt cag aga gac tgc cgg gtg cta gaa       1545
Tyr Asn Ala Leu Met Lys Thr Leu Gln Arg Asp Cys Arg Val Leu Glu           
245                 250                 255                 260           

agc ttc aag atc atg gat tat agc ctt ctg ttg gga att cat ttc ctg       1593
Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His Phe Leu           
                265                 270                 275               

gac cat tcc ctc aaa gag aaa gag gag gag acc cca caa aat gtg cct       1641
Asp His Ser Leu Lys Glu Lys Glu Glu Glu Thr Pro Gln Asn Val Pro           
            280                 285                 290                   

gat gct aag cgg act ggg atg cag aag gtt ctc tac tca aca gcc atg       1689
Asp Ala Lys Arg Thr Gly Met Gln Lys Val Leu Tyr Ser Thr Ala Met           
        295                 300                 305                       

gaa tct atc cag ggt cca ggg aaa tct gga gat ggg ata atc aca gag       1737
Glu Ser Ile Gln Gly Pro Gly Lys Ser Gly Asp Gly Ile Ile Thr Glu           
    310                 315                 320                           

aac cca gac aca atg gga ggc att cca gct aaa agc cat agg gga gaa       1785
Asn Pro Asp Thr Met Gly Gly Ile Pro Ala Lys Ser His Arg Gly Glu           
325                 330                 335                 340           

aaa cta ctt tta ttt atg ggc att att gac att ctg caa tca tat agg       1833
Lys Leu Leu Leu Phe Met Gly Ile Ile Asp Ile Leu Gln Ser Tyr Arg           
                345                 350                 355               

tta atg aag aag tta gaa cat tcc tgg aaa gct ctt gtt tat gat ggg       1881
Leu Met Lys Lys Leu Glu His Ser Trp Lys Ala Leu Val Tyr Asp Gly           
            360                 365                 370                   

gac act gtt tct gtt cat aga cca agc ttt tat gca gac aga ttt ctt       1929
Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala Asp Arg Phe Leu           
        375                 380                 385                       

aag ttc atg aat tcc aga gtt ttc aag aaa att caa gct ttg aag gct       1977
Lys Phe Met Asn Ser Arg Val Phe Lys Lys Ile Gln Ala Leu Lys Ala           
    390                 395                 400                           

tca ccg tct aag aaa cgg tgc aat tca atc gcc gcc cta aag gcc act       2025
Ser Pro Ser Lys Lys Arg Cys Asn Ser Ile Ala Ala Leu Lys Ala Thr           
405                 410                 415                 420           

tca cag gag att gtg tcc tca att agc cag gaa tgg aag gat gag aag       2073
Ser Gln Glu Ile Val Ser Ser Ile Ser Gln Glu Trp Lys Asp Glu Lys           
                425                 430                 435               

cgg gat ttg ctg act gaa gga caa agt ttt agc agc ctt gat gaa gaa       2121
Arg Asp Leu Leu Thr Glu Gly Gln Ser Phe Ser Ser Leu Asp Glu Glu           
            440                 445                 450                   

gcc ctg gga tcc cga cac agg cca gac ctg gtc cct agc act cca tca       2169
Ala Leu Gly Ser Arg His Arg Pro Asp Leu Val Pro Ser Thr Pro Ser           
        455                 460                 465                       

ctg ttt gaa gct gct tcc ttg gca acc aca att tca tct tct tcc tta       2217
Leu Phe Glu Ala Ala Ser Leu Ala Thr Thr Ile Ser Ser Ser Ser Leu           
    470                 475                 480                           

tac gtc aat gag cac tat cca cac gac agg cct aca ctc tat tca aac       2265
Tyr Val Asn Glu His Tyr Pro His Asp Arg Pro Thr Leu Tyr Ser Asn           
485                 490                 495                 500           

agc aaa ggg tta cct tcc agt tca aca ttt acc ttg gaa gag ggg acc       2313
Ser Lys Gly Leu Pro Ser Ser Ser Thr Phe Thr Leu Glu Glu Gly Thr           
                505                 510                 515               

atc tac ttg acc gct gag ccc aac act ctg gaa gtg cag gat gac aat       2361
Ile Tyr Leu Thr Ala Glu Pro Asn Thr Leu Glu Val Gln Asp Asp Asn           
            520                 525                 530                   

gct tct gtg ctt gac gtc tat tta taa gtgaaaatgg tgatcaccta             2408
Ala Ser Val Leu Asp Val Tyr Leu                                           
        535                 540                                           

agcacatgga tgagacgtga gcacagttat ggcagagaag tttctccgca ccagaattat     2468

ccacagcaac ttggctgagc cccactacac acagagaaat catcaacctg acttaagagt     2528

tttcaagatg tcaacttcag gctgatcagc agatgggatg tgaaaaatac taccctattc     2588

tatcatttgc tgttgcttgc tgaactgtga agaactgcat gaactatatt taagctgctt     2648

tctgtaccat tgccaatcac ctttttggag ttggaagtgc tattttccta tggacttttg     2708

cattatttca ttgtgcatgc atccagtgat tatacataag caacatatgt aatctgctta     2768

tatattttta aaaatccatc cacacacatg gtaaattaag tataaattct tttgcaaaat     2828

tatagttcat gtcattgaaa gtttaaattg gtttcattta aagatcaata tactaggtct     2888

gccttcactt tatagaaaac tagcttctat aaagattttt tcactgttta ctagtgaaat     2948

gagaaaagca aagctattta taaaaggcct tatgtcgtgt acatacattg tctttgaaat     3008

atttgtgatc tagtttattg cttgtaaaag agaaattata taatttattt agtaaatact     3068

actgtaaact atagttttgt gagagaaata aaatattttg ttctcaa                   3115


<210>  44
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Ser Ala Ala Glu Asn Gly Glu Ala Ala Pro Gly Lys Gln Asn 
1               5                   10                  15      


Glu Glu Lys Thr Tyr Lys Lys Thr Ala Ser Ser Ala Ile Lys Gly Ala 
            20                  25                  30          


Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly Asn Leu Thr Ser Lys Pro 
        35                  40                  45              


Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser Val Phe 
    50                  55                  60                  


Leu Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Tyr Pro Asp 
65                  70                  75                  80  


Phe Arg Phe Lys Thr Tyr Ala Pro Leu Ala Phe Arg Tyr Phe Arg Glu 
                85                  90                  95      


Leu Phe Gly Ile Lys Pro Asp Asp Tyr Leu Tyr Ser Ile Cys Ser Glu 
            100                 105                 110         


Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu Phe Phe 
        115                 120                 125             


Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Gln His Lys Glu 
    130                 135                 140                 


Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn Leu Asn 
145                 150                 155                 160 


Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr Cys Met 
                165                 170                 175     


Gln Ser Gly Gly Ile Asn Ile Arg Ile Val Val Met Asn Asn Val Leu 
            180                 185                 190         


Pro Arg Ser Met Arg Met His Phe Thr Tyr Asp Leu Lys Gly Ser Thr 
        195                 200                 205             


Tyr Lys Arg Arg Ala Ser Arg Lys Glu Arg Glu Lys Ser Asn Pro Thr 
    210                 215                 220                 


Phe Lys Asp Leu Asp Phe Leu Gln Asp Met His Glu Gly Leu Tyr Phe 
225                 230                 235                 240 


Asp Thr Glu Thr Tyr Asn Ala Leu Met Lys Thr Leu Gln Arg Asp Cys 
                245                 250                 255     


Arg Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly 
            260                 265                 270         


Ile His Phe Leu Asp His Ser Leu Lys Glu Lys Glu Glu Glu Thr Pro 
        275                 280                 285             


Gln Asn Val Pro Asp Ala Lys Arg Thr Gly Met Gln Lys Val Leu Tyr 
    290                 295                 300                 


Ser Thr Ala Met Glu Ser Ile Gln Gly Pro Gly Lys Ser Gly Asp Gly 
305                 310                 315                 320 


Ile Ile Thr Glu Asn Pro Asp Thr Met Gly Gly Ile Pro Ala Lys Ser 
                325                 330                 335     


His Arg Gly Glu Lys Leu Leu Leu Phe Met Gly Ile Ile Asp Ile Leu 
            340                 345                 350         


Gln Ser Tyr Arg Leu Met Lys Lys Leu Glu His Ser Trp Lys Ala Leu 
        355                 360                 365             


Val Tyr Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 
    370                 375                 380                 


Asp Arg Phe Leu Lys Phe Met Asn Ser Arg Val Phe Lys Lys Ile Gln 
385                 390                 395                 400 


Ala Leu Lys Ala Ser Pro Ser Lys Lys Arg Cys Asn Ser Ile Ala Ala 
                405                 410                 415     


Leu Lys Ala Thr Ser Gln Glu Ile Val Ser Ser Ile Ser Gln Glu Trp 
            420                 425                 430         


Lys Asp Glu Lys Arg Asp Leu Leu Thr Glu Gly Gln Ser Phe Ser Ser 
        435                 440                 445             


Leu Asp Glu Glu Ala Leu Gly Ser Arg His Arg Pro Asp Leu Val Pro 
    450                 455                 460                 


Ser Thr Pro Ser Leu Phe Glu Ala Ala Ser Leu Ala Thr Thr Ile Ser 
465                 470                 475                 480 


Ser Ser Ser Leu Tyr Val Asn Glu His Tyr Pro His Asp Arg Pro Thr 
                485                 490                 495     


Leu Tyr Ser Asn Ser Lys Gly Leu Pro Ser Ser Ser Thr Phe Thr Leu 
            500                 505                 510         


Glu Glu Gly Thr Ile Tyr Leu Thr Ala Glu Pro Asn Thr Leu Glu Val 
        515                 520                 525             


Gln Asp Asp Asn Ala Ser Val Leu Asp Val Tyr Leu 
    530                 535                 540 


<210>  45
<211>  636
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (80)..(577)

<400>  45
gtgacagccg gggtgtgtgt ccgccgggct tggtgcctcc ggtggccctg cagcaccgtc       60

ccacctctgc caccctccg atg ggg ccg cta cct gtg tgc ctg cca atc atg       112
                     Met Gly Pro Leu Pro Val Cys Leu Pro Ile Met          
                     1               5                   10               

ctg ctc ctg cta ctg ccg tcg ctg ctg ctg ctg ctg ctt cta cct ggc        160
Leu Leu Leu Leu Leu Pro Ser Leu Leu Leu Leu Leu Leu Leu Pro Gly           
            15                  20                  25                    

ccc ggg tcc ggc gag gcc tcc agg ata tta cgt gtg cac cgg cgt ggg        208
Pro Gly Ser Gly Glu Ala Ser Arg Ile Leu Arg Val His Arg Arg Gly           
        30                  35                  40                        

atc ctg gaa ctg gca gga act gtg ggt tgt gtt ggt ccc cga acc ccc        256
Ile Leu Glu Leu Ala Gly Thr Val Gly Cys Val Gly Pro Arg Thr Pro           
    45                  50                  55                            

atc gcc tat atg aaa tat ggt tgc ttt tgt ggc ttg gga ggc cat ggc        304
Ile Ala Tyr Met Lys Tyr Gly Cys Phe Cys Gly Leu Gly Gly His Gly           
60                  65                  70                  75            

cag ccc cgc gat gcc att gac tgg tgc tgc cat ggc cac gac tgt tgt        352
Gln Pro Arg Asp Ala Ile Asp Trp Cys Cys His Gly His Asp Cys Cys           
                80                  85                  90                

tac act cga gct gag gag gcc ggc tgc agc ccc aag aca gag cgc tac        400
Tyr Thr Arg Ala Glu Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg Tyr           
            95                  100                 105                   

tcc tgg cag tgc gtc aat cag agc gtc ctg tgc gga ccg gca gag aac        448
Ser Trp Gln Cys Val Asn Gln Ser Val Leu Cys Gly Pro Ala Glu Asn           
        110                 115                 120                       

aaa tgc caa gaa ctg ttg tgc aag tgt gac cag gag att gct aac tgc        496
Lys Cys Gln Glu Leu Leu Cys Lys Cys Asp Gln Glu Ile Ala Asn Cys           
    125                 130                 135                           

tta gcc caa act gag tac aac tta aag tac ctc ttc tac ccc cag ttc        544
Leu Ala Gln Thr Glu Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln Phe           
140                 145                 150                 155           

cta tgt gag ccg gac tcg ccc aag tgt gac tga ctaccttgac ttgaaatgct      597
Leu Cys Glu Pro Asp Ser Pro Lys Cys Asp                                   
                160                 165                                   

cttttgcaca aggaaataaa gcgtcctctc agtaatgaa                             636


<210>  46
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Pro Leu Pro Val Cys Leu Pro Ile Met Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ser Leu Leu Leu Leu Leu Leu Leu Pro Gly Pro Gly Ser Gly Glu 
            20                  25                  30          


Ala Ser Arg Ile Leu Arg Val His Arg Arg Gly Ile Leu Glu Leu Ala 
        35                  40                  45              


Gly Thr Val Gly Cys Val Gly Pro Arg Thr Pro Ile Ala Tyr Met Lys 
    50                  55                  60                  


Tyr Gly Cys Phe Cys Gly Leu Gly Gly His Gly Gln Pro Arg Asp Ala 
65                  70                  75                  80  


Ile Asp Trp Cys Cys His Gly His Asp Cys Cys Tyr Thr Arg Ala Glu 
                85                  90                  95      


Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg Tyr Ser Trp Gln Cys Val 
            100                 105                 110         


Asn Gln Ser Val Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln Glu Leu 
        115                 120                 125             


Leu Cys Lys Cys Asp Gln Glu Ile Ala Asn Cys Leu Ala Gln Thr Glu 
    130                 135                 140                 


Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln Phe Leu Cys Glu Pro Asp 
145                 150                 155                 160 


Ser Pro Lys Cys Asp 
                165 


<210>  47
<211>  1751
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (31)..(489)

<400>  47
acacccacag ttgagctgcg ctggccagag atg cct gcc cac agc ctg gtg atg        54
                                 Met Pro Ala His Ser Leu Val Met          
                                 1               5                        

agc agc ccg gcc ctc ccg gcc ttc ctg ctc tgc agc acg ctg ctg gtc        102
Ser Ser Pro Ala Leu Pro Ala Phe Leu Leu Cys Ser Thr Leu Leu Val           
    10                  15                  20                            

atc aag atg tac gtg gtg gcc atc atc acg ggc caa gtg agg ctg cgg        150
Ile Lys Met Tyr Val Val Ala Ile Ile Thr Gly Gln Val Arg Leu Arg           
25                  30                  35                  40            

aag aag gcc ttt gcc aac ccc gag gat gcc ctg aga cac gga ggc ccc        198
Lys Lys Ala Phe Ala Asn Pro Glu Asp Ala Leu Arg His Gly Gly Pro           
                45                  50                  55                

cag tat tgc agg agc gac ccc gac gtg gaa cgc tgc ctc agg gcc cac        246
Gln Tyr Cys Arg Ser Asp Pro Asp Val Glu Arg Cys Leu Arg Ala His           
            60                  65                  70                    

cgg aac gac atg gag acc atc tac ccc ttc ctt ttc ctg ggc ttc gtc        294
Arg Asn Asp Met Glu Thr Ile Tyr Pro Phe Leu Phe Leu Gly Phe Val           
        75                  80                  85                        

tac tcc ttt ctg ggt cct aac cct ttt gtc gcc tgg atg cac ttc ctg        342
Tyr Ser Phe Leu Gly Pro Asn Pro Phe Val Ala Trp Met His Phe Leu           
    90                  95                  100                           

gtc ttc ctc gtg ggc cgt gtg gca cac acc gtg gcc tac ctg ggg aag        390
Val Phe Leu Val Gly Arg Val Ala His Thr Val Ala Tyr Leu Gly Lys           
105                 110                 115                 120           

ctg cgg gca ccc atc cgc tcc gtg acc tac acc ctg gcc cag ctc ccc        438
Leu Arg Ala Pro Ile Arg Ser Val Thr Tyr Thr Leu Ala Gln Leu Pro           
                125                 130                 135               

tgc gcc tcc atg gct ctg cag atc ctc tgg gaa gcg gcc cgc cac ctg        486
Cys Ala Ser Met Ala Leu Gln Ile Leu Trp Glu Ala Ala Arg His Leu           
            140                 145                 150                   

tga ccagcagctg atgcctcctt ggccaccaga ccatgggcca agagccgccg             539

tggctatacc tggggacttg atgttccttc cagattgtgg tgggccctga gtcctggttt      599

cctggcagcc tgctgcgcgt gtgggtctct gggcacagtg ggcctgtgtg tgtgcccgtg      659

tgtgtgtatg tgtgtgtgta tgtttcttag ccccttggat tcctgcacga agtggctgat      719

gggaaccatt tcaagacaga ttgtgaagat tgatagaaaa tccttcagct aaagtaacag      779

agcatcaaaa acatcactcc ctctccctcc ctaacagtga aaagagagaa gggagactct      839

atttaagatt cccaaaccta atgatcatct gaatcccggg ctaagaatgc agacttttca      899

gactgacccc agaaattctg gcccagccaa tctagaggca agcctggcca tctgtatttt      959

tttttttcca agacagagtc ttgctctgtt gcccaagctg gagtgaagtg gtacaatctg     1019

gctcactgca gcctccgcct cccgggttca agcgattctc ccgcctcagc ctcctgagta     1079

gctgggatta caggcgcgta tcaccatacc cagctaattt ttgtattttt agtagagacg     1139

ggttcaccat gttgcccagg agggtctcga actcctggcc tcaagtgatc caccggcctc     1199

ggcctcccaa agtgctggga tgacaggcat gaatcactgt gctcagccac catctggagt     1259

tttaaaaggc tcccatgtga gtccctgtga tggccaggcc aggggacccc tgccagttct     1319

ctgtggaagc aaggctgggg tcttgggttc ctgtatggtg gaagctgggt gagccaagga     1379

cagggctggc tcctctgccc ccgctgacgc ttcccttgcc gttggctttg gatgtctttg     1439

ctgcagtctt ctctctggct caggtgtggg tgggaggggc ccacaggaag ctcagccttc     1499

tcctcccaag gtttgagtcc ctccaaaggg cagtgggtgg aggaccggga gctttgggtg     1559

accagccact caaaggaact ttctggtccc ttcagtatct tcaaggtttg gaaactgcaa     1619

atgtcccctt gatggggaat ccgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     1679

gtgtgtgtgt tttctcctag acccgtgacc tgagatgtgt gatttttagt cattaaatgg     1739

aagtgtctgc ca                                                         1751


<210>  48
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Ala His Ser Leu Val Met Ser Ser Pro Ala Leu Pro Ala Phe 
1               5                   10                  15      


Leu Leu Cys Ser Thr Leu Leu Val Ile Lys Met Tyr Val Val Ala Ile 
            20                  25                  30          


Ile Thr Gly Gln Val Arg Leu Arg Lys Lys Ala Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Ala Leu Arg His Gly Gly Pro Gln Tyr Cys Arg Ser Asp Pro Asp 
    50                  55                  60                  


Val Glu Arg Cys Leu Arg Ala His Arg Asn Asp Met Glu Thr Ile Tyr 
65                  70                  75                  80  


Pro Phe Leu Phe Leu Gly Phe Val Tyr Ser Phe Leu Gly Pro Asn Pro 
                85                  90                  95      


Phe Val Ala Trp Met His Phe Leu Val Phe Leu Val Gly Arg Val Ala 
            100                 105                 110         


His Thr Val Ala Tyr Leu Gly Lys Leu Arg Ala Pro Ile Arg Ser Val 
        115                 120                 125             


Thr Tyr Thr Leu Ala Gln Leu Pro Cys Ala Ser Met Ala Leu Gln Ile 
    130                 135                 140                 


Leu Trp Glu Ala Ala Arg His Leu 
145                 150         


<210>  49
<211>  1224
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (147)..(623)

<400>  49
actggagaca ctgaagaagg caggggccct tagagtcttg gttgccaaac agatttgcag       60

atcaaggaga acccaggagt ttcaaagaag cgctagtaag gtctctgaga tccttgcact      120

agctacatcc tcagggtagg aggaag atg gct tcc aga agc atg cgg ctg ctc       173
                             Met Ala Ser Arg Ser Met Arg Leu Leu          
                             1               5                            

cta ttg ctg agc tgc ctg gcc aaa aca gga gtc ctg ggt gat atc atc        221
Leu Leu Leu Ser Cys Leu Ala Lys Thr Gly Val Leu Gly Asp Ile Ile           
10                  15                  20                  25            

atg aga ccc agc tgt gct cct gga tgg ttt tac cac aag tcc aat tgc        269
Met Arg Pro Ser Cys Ala Pro Gly Trp Phe Tyr His Lys Ser Asn Cys           
                30                  35                  40                

tat ggt tac ttc agg aag ctg agg aac tgg tct gat gcc gag ctc gag        317
Tyr Gly Tyr Phe Arg Lys Leu Arg Asn Trp Ser Asp Ala Glu Leu Glu           
            45                  50                  55                    

tgt cag tct tac gga aac gga gcc cac ctg gca tct atc ctg agt tta        365
Cys Gln Ser Tyr Gly Asn Gly Ala His Leu Ala Ser Ile Leu Ser Leu           
        60                  65                  70                        

aag gaa gcc agc acc ata gca gag tac ata agt ggc tat cag aga agc        413
Lys Glu Ala Ser Thr Ile Ala Glu Tyr Ile Ser Gly Tyr Gln Arg Ser           
    75                  80                  85                            

cag ccg ata tgg att ggc ctg cac gac cca cag aag agg cag cag tgg        461
Gln Pro Ile Trp Ile Gly Leu His Asp Pro Gln Lys Arg Gln Gln Trp           
90                  95                  100                 105           

cag tgg att gat ggg gcc atg tat ctg tac aga tcc tgg tct ggc aag        509
Gln Trp Ile Asp Gly Ala Met Tyr Leu Tyr Arg Ser Trp Ser Gly Lys           
                110                 115                 120               

tcc atg ggt ggg aac aag cac tgt gct gag atg agc tcc aat aac aac        557
Ser Met Gly Gly Asn Lys His Cys Ala Glu Met Ser Ser Asn Asn Asn           
            125                 130                 135                   

ttt tta act tgg agc agc aac gaa tgc aac aag cgc caa cac ttc ctg        605
Phe Leu Thr Trp Ser Ser Asn Glu Cys Asn Lys Arg Gln His Phe Leu           
        140                 145                 150                       

tgc aag tac cga cca tag agcaagaatc aagattctgc taactcctgc               653
Cys Lys Tyr Arg Pro                                                       
    155                                                                   

acagccccgt cctcttcctt tctgctagcc tggctaaatc tgctcattat ttcagagggg      713

aaacctagca aactaagagt gataagggcc ctactacact ggctttttta ggcttagaga      773

cagaaacttt agcattggcc cagtagtggc ttctagctct aaatgtttgc cccgccatcc      833

ctttccacag tatccttctt ccctcctccc ctgtctctgg ctgtctcgag cagtctagaa      893

gagtgcatct ccagcctatg aaacagctgg gtctttggcc ataagaagta aagatttgaa      953

gacagaagga agaaactcag gagtaagctt ctagacccct tcagcttcta cacccttctg     1013

ccctctctcc attgcctgca ccccacccca gccactcaac tcctgcttgt ttttcctttg     1073

gccatgggaa ggtttaccag tagaatcctt gctaggttga tgtgggccat acattccttt     1133

aataaaccat tgtgtacata agaggttgct gtgttccagt tcagtaatgg tgaatgtgga     1193

aaagtgaaat aagaccaaga aatacaccca a                                    1224


<210>  50
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ser Arg Ser Met Arg Leu Leu Leu Leu Leu Ser Cys Leu Ala 
1               5                   10                  15      


Lys Thr Gly Val Leu Gly Asp Ile Ile Met Arg Pro Ser Cys Ala Pro 
            20                  25                  30          


Gly Trp Phe Tyr His Lys Ser Asn Cys Tyr Gly Tyr Phe Arg Lys Leu 
        35                  40                  45              


Arg Asn Trp Ser Asp Ala Glu Leu Glu Cys Gln Ser Tyr Gly Asn Gly 
    50                  55                  60                  


Ala His Leu Ala Ser Ile Leu Ser Leu Lys Glu Ala Ser Thr Ile Ala 
65                  70                  75                  80  


Glu Tyr Ile Ser Gly Tyr Gln Arg Ser Gln Pro Ile Trp Ile Gly Leu 
                85                  90                  95      


His Asp Pro Gln Lys Arg Gln Gln Trp Gln Trp Ile Asp Gly Ala Met 
            100                 105                 110         


Tyr Leu Tyr Arg Ser Trp Ser Gly Lys Ser Met Gly Gly Asn Lys His 
        115                 120                 125             


Cys Ala Glu Met Ser Ser Asn Asn Asn Phe Leu Thr Trp Ser Ser Asn 
    130                 135                 140                 


Glu Cys Asn Lys Arg Gln His Phe Leu Cys Lys Tyr Arg Pro 
145                 150                 155             


<210>  51
<211>  977
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (350)..(646)

<400>  51
agagcagggg ttgcctcccc tcaccccggt ccaggatgcc cagtccccac gacacctccc       60

acttcccact gtggcctggg tgggctcagg ggctgccctt gacctggcct agagccctcc      120

cccagctggt ggtggagctg gcactctctg ggagggaggg ggctgggagg gaatgagtgg      180

gaatggcaag aggccagggt ttggtgggat caggttgagg caggtttggt ttccttaaaa      240

tgccaagttg ggggccagtg gggcccacat ataaatcctc accctgggag cctggctgcc      300

ttgctctcct tcctgggtct gtctctgcca cctggtctgc cacagatcc atg atg tgc      358
                                                      Met Met Cys         
                                                      1                   

agt tct ctg gag cag gcg ctg gct gtg ctg gtc act acc ttc cac aag        406
Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr Phe His Lys           
    5                   10                  15                            

tac tcc tgc caa gag ggc gac aag ttc aag ctg agt aag ggg gaa atg        454
Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys Gly Glu Met           
20                  25                  30                  35            

aag gaa ctt ctg cac aag gag ctg ccc agc ttt gtg ggg gag aaa gtg        502
Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly Glu Lys Val           
                40                  45                  50                

gat gag gag ggg ctg aag aag ctg atg ggc agc ctg gat gag aac agt        550
Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp Glu Asn Ser           
            55                  60                  65                    

gac cag cag gtg gac ttc cag gag tat gct gtt ttc ctg gca ctc atc        598
Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu Ala Leu Ile           
        70                  75                  80                        

act gtc atg tgc aat gac ttc ttc cag ggc tgc cca gac cga ccc tga        646
Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp Arg Pro               
    85                  90                  95                            

agcagaactc ttgacttcct gccatggatc tcttgggccc aggactgttg atgcctttga      706

gttttgtatt caataaactt tttttgtctg ttgataatat tttaattgct cagtgatgtt      766

ccataacccg gctggctcag ctggagtgct gggagatgag ggcctcctgg atcctgctcc      826

cttctgggct ctgactctcc tggaaatctc tccaaggcca gagctatgct ttaggtctca      886

attttggaat ttcaaacacc agcaaaaaat tggaaatcga gataggttgc tgacttttat      946

tttgtcaaat aaagatatta aaaaaggcaa a                                     977


<210>  52
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Met Cys Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr 
1               5                   10                  15      


Phe His Lys Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys 
            20                  25                  30          


Gly Glu Met Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly 
        35                  40                  45              


Glu Lys Val Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp 
    50                  55                  60                  


Glu Asn Ser Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu 
65                  70                  75                  80  


Ala Leu Ile Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp 
                85                  90                  95      


Arg Pro 
        


<210>  53
<211>  3330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (327)..(2042)

<400>  53
ggcggcggcg gcggcggaga gagctggctc agggcgtccg ctaggctcgg acgacctgct       60

gagcctccca aaccgcttcc ataaggcttt gcctttccaa cttcagctac agtgttagct      120

aagtttggaa agaaggaaaa aagaaaatcc ctgggcccct tttcttttgt tctttgccaa      180

agtcgtcgtt gtagtctttt tgcccaaggc tgttgtgttt ttagaggtgc tatctccagt      240

tccttgcact cctgttaaca agcacctcag cgagagcagc agcagcgata gcagccgcag      300

aagagccagc ggggtcgcct agtgtc atg acc agg gcg gga gat cac aac cgc       353
                             Met Thr Arg Ala Gly Asp His Asn Arg          
                             1               5                            

cag aga gga tgc tgt gga tcc ttg gcc gac tac ctg acc tct gca aaa        401
Gln Arg Gly Cys Cys Gly Ser Leu Ala Asp Tyr Leu Thr Ser Ala Lys           
10                  15                  20                  25            

ttc ctt ctc tac ctt ggt cat tct ctc tct act tgg gga gat cgg atg        449
Phe Leu Leu Tyr Leu Gly His Ser Leu Ser Thr Trp Gly Asp Arg Met           
                30                  35                  40                

tgg cac ttt gcg gtg tct gtg ttt ctg gta gag ctc tat gga aac agc        497
Trp His Phe Ala Val Ser Val Phe Leu Val Glu Leu Tyr Gly Asn Ser           
            45                  50                  55                    

ctc ctt ttg aca gca gtc tac ggg ctg gtg gtg gca ggg tct gtt ctg        545
Leu Leu Leu Thr Ala Val Tyr Gly Leu Val Val Ala Gly Ser Val Leu           
        60                  65                  70                        

gtc ctg gga gcc atc atc ggt gac tgg gtg gac aag aat gct aga ctt        593
Val Leu Gly Ala Ile Ile Gly Asp Trp Val Asp Lys Asn Ala Arg Leu           
    75                  80                  85                            

aaa gtg gcc cag acc tcg ctg gtg gta cag aat gtt tca gtc atc ctg        641
Lys Val Ala Gln Thr Ser Leu Val Val Gln Asn Val Ser Val Ile Leu           
90                  95                  100                 105           

tgt gga atc atc ctg atg atg gtt ttc tta cat aaa cat gag ctt ctg        689
Cys Gly Ile Ile Leu Met Met Val Phe Leu His Lys His Glu Leu Leu           
                110                 115                 120               

acc atg tac cat gga tgg gtt ctc act tcc tgc tat atc ctg atc atc        737
Thr Met Tyr His Gly Trp Val Leu Thr Ser Cys Tyr Ile Leu Ile Ile           
            125                 130                 135                   

act att gca aat att gca aat ttg gcc agt act gct act gca atc aca        785
Thr Ile Ala Asn Ile Ala Asn Leu Ala Ser Thr Ala Thr Ala Ile Thr           
        140                 145                 150                       

atc caa agg gat tgg att gtt gtt gtt gca gga gaa gac aga agc aaa        833
Ile Gln Arg Asp Trp Ile Val Val Val Ala Gly Glu Asp Arg Ser Lys           
    155                 160                 165                           

cta gca aat atg aat gcc aca ata cga agg att gac cag tta acc aac        881
Leu Ala Asn Met Asn Ala Thr Ile Arg Arg Ile Asp Gln Leu Thr Asn           
170                 175                 180                 185           

atc tta gcc ccc atg gct gtt ggc cag att atg aca ttt ggc tcc cca        929
Ile Leu Ala Pro Met Ala Val Gly Gln Ile Met Thr Phe Gly Ser Pro           
                190                 195                 200               

gtc atc ggc tgt ggc ttt att tcg gga tgg aac ttg gta tcc atg tgc        977
Val Ile Gly Cys Gly Phe Ile Ser Gly Trp Asn Leu Val Ser Met Cys           
            205                 210                 215                   

gtg gag tac gtt ctg ctc tgg aag gtt tac cag aaa acc cca gct cta       1025
Val Glu Tyr Val Leu Leu Trp Lys Val Tyr Gln Lys Thr Pro Ala Leu           
        220                 225                 230                       

gct gtg aaa gct ggt ctt aaa gaa gag gaa act gaa ttg aaa cag ctg       1073
Ala Val Lys Ala Gly Leu Lys Glu Glu Glu Thr Glu Leu Lys Gln Leu           
    235                 240                 245                           

aat tta cac aaa gat act gag cca aaa ccc ctg gag gga act cat cta       1121
Asn Leu His Lys Asp Thr Glu Pro Lys Pro Leu Glu Gly Thr His Leu           
250                 255                 260                 265           

atg ggt gtg aaa gac tct aac atc cat gag ctt gaa cat gag caa gag       1169
Met Gly Val Lys Asp Ser Asn Ile His Glu Leu Glu His Glu Gln Glu           
                270                 275                 280               

cct act tgt gcc tcc cag atg gct gag ccc ttc cgt acc ttc cga gat       1217
Pro Thr Cys Ala Ser Gln Met Ala Glu Pro Phe Arg Thr Phe Arg Asp           
            285                 290                 295                   

gga tgg gtc tcc tac tac aac cag cct gtg ttt ctg gct ggc atg ggt       1265
Gly Trp Val Ser Tyr Tyr Asn Gln Pro Val Phe Leu Ala Gly Met Gly           
        300                 305                 310                       

ctt gct ttc ctt tat atg act gtc ctg ggc ttt gac tgc atc acc aca       1313
Leu Ala Phe Leu Tyr Met Thr Val Leu Gly Phe Asp Cys Ile Thr Thr           
    315                 320                 325                           

ggg tac gcc tac act cag gga ctg agt ggt tcc atc ctc agt att ttg       1361
Gly Tyr Ala Tyr Thr Gln Gly Leu Ser Gly Ser Ile Leu Ser Ile Leu           
330                 335                 340                 345           

atg gga gca tca gct ata act gga ata atg gga act gta gct ttt act       1409
Met Gly Ala Ser Ala Ile Thr Gly Ile Met Gly Thr Val Ala Phe Thr           
                350                 355                 360               

tgg cta cgt cga aaa tgt ggt ttg gtt cgg aca ggt ctg atc tca gga       1457
Trp Leu Arg Arg Lys Cys Gly Leu Val Arg Thr Gly Leu Ile Ser Gly           
            365                 370                 375                   

ttg gca cag ctt tcc tgt ttg atc ttg tgt gtg atc tct gta ttc atg       1505
Leu Ala Gln Leu Ser Cys Leu Ile Leu Cys Val Ile Ser Val Phe Met           
        380                 385                 390                       

cct gga agc ccc ctg gac ttg tcc gtt tct cct ttt gaa gat atc cga       1553
Pro Gly Ser Pro Leu Asp Leu Ser Val Ser Pro Phe Glu Asp Ile Arg           
    395                 400                 405                           

tca agg ttc att caa gga gag tca att aca cct acc aag ata cct gaa       1601
Ser Arg Phe Ile Gln Gly Glu Ser Ile Thr Pro Thr Lys Ile Pro Glu           
410                 415                 420                 425           

att aca act gaa ata tac atg tct aat ggg tct aat tct gct aat att       1649
Ile Thr Thr Glu Ile Tyr Met Ser Asn Gly Ser Asn Ser Ala Asn Ile           
                430                 435                 440               

gtc ccg gag aca agt cct gaa tct gtg ccc ata atc tct gtc agt ctg       1697
Val Pro Glu Thr Ser Pro Glu Ser Val Pro Ile Ile Ser Val Ser Leu           
            445                 450                 455                   

ctg ttt gca ggc gtc att gct gct aga atc ggt ctt tgg tcc ttt gat       1745
Leu Phe Ala Gly Val Ile Ala Ala Arg Ile Gly Leu Trp Ser Phe Asp           
        460                 465                 470                       

tta act gtg aca cag ttg ctg caa gaa aat gta att gaa tct gaa aga       1793
Leu Thr Val Thr Gln Leu Leu Gln Glu Asn Val Ile Glu Ser Glu Arg           
    475                 480                 485                           

ggc att ata aat ggt gta cag aac tcc atg aac tat ctt ctt gat ctt       1841
Gly Ile Ile Asn Gly Val Gln Asn Ser Met Asn Tyr Leu Leu Asp Leu           
490                 495                 500                 505           

ctg cat ttc atc atg gtc atc ctg gct cca aat cct gaa gct ttt ggc       1889
Leu His Phe Ile Met Val Ile Leu Ala Pro Asn Pro Glu Ala Phe Gly           
                510                 515                 520               

ttg ctc gta ttg att tca gtc tcc ttt gtg gca atg ggc cac att atg       1937
Leu Leu Val Leu Ile Ser Val Ser Phe Val Ala Met Gly His Ile Met           
            525                 530                 535                   

tat ttc cga ttt gcc caa aat act ctg gga aac aag ctc ttt gct tgc       1985
Tyr Phe Arg Phe Ala Gln Asn Thr Leu Gly Asn Lys Leu Phe Ala Cys           
        540                 545                 550                       

ggt cct gat gca aaa gaa gtt agg aag gaa aat caa gca aat aca tct       2033
Gly Pro Asp Ala Lys Glu Val Arg Lys Glu Asn Gln Ala Asn Thr Ser           
    555                 560                 565                           

gtt gtt tga gacagtttaa ctgttgctat cctgttacta gattatatag               2082
Val Val                                                                   
570                                                                       

agcacatgtg cttattttgt actgcagaat tccaataaat ggctgggtgt tttgctctgt     2142

ttttaccaca gctgtgcctt gagaactaaa agctgtttag gaaacctaag tcagcagaaa     2202

ttaactgatt aatttccctt atgttgaggc atggaaaaaa aattggaaaa gaaaaactca     2262

gtttaaatac ggagactata atgataacac tgaattcccc tatttctcat gagtagatac     2322

aatcttacgt aaaagagtgg ttagtcacgt gaattcagtt atcatttgac agattcttat     2382

ctgtactaga attcagatat gtcagttttc tgcaaaactc actcttgttc aagactagct     2442

aatttatttt tttgcatctt agttattttt aaaaacaaat tcttcaagta tgaagactaa     2502

attttgataa ctaatattat ccttattgat cctattgatc ttaaggtatt tacatgtatg     2562

tggaaaaaca aaacacttaa ctagaattct ctaataaggt ttatggttta gcttaaagag     2622

cacctttgta tttttattat cagatggggc aacatattgt atgaagcata tgtagcactt     2682

cacagcatgg ttatcatgta agctgcaggt agaagcaaag ctgtaaagta gatttatcac     2742

acaatgactg catacagact tcaaatatgt caatagtttg gtcatagaac ctagaagcca     2802

aaagccacac agaagggcaa gaatcccaat ttaactcatg ttatcatcat tagtgatctg     2862

tgttgtagaa catgagggtg taagccttca gcctggcaag ttacatgtag aaagcccaca     2922

cttgtgaagg ttttgtttta caaatcactt gatttaacac actcaggtag aatattttta     2982

tttttactgt tttataccca gaagttattt ctacattgtt ctacagcaag aatattcata     3042

aaagtatccc tttcaaatgc ctttgagaag aatagaagaa aaaaagtttg tatatatttt     3102

aaaaaattgt tttaaaagtc agtttgcaac atgtctgtac caagatggta ctttgcctta     3162

accgtttata tgcactttca tggagactgc aatacgttgc tatgagcact ttctttatcc     3222

ttggagttta atcctttgct tcatctttct acagtatgac ataatgattt gctatgttgt     3282

aaaatctttg taaaaaattt ctatataaaa atattttgaa aatcttaa                  3330


<210>  54
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Arg Ala Gly Asp His Asn Arg Gln Arg Gly Cys Cys Gly Ser 
1               5                   10                  15      


Leu Ala Asp Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
            20                  25                  30          


Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
        35                  40                  45              


Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
    50                  55                  60                  


Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
65                  70                  75                  80  


Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                85                  90                  95      


Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
            100                 105                 110         


Val Phe Leu His Lys His Glu Leu Leu Thr Met Tyr His Gly Trp Val 
        115                 120                 125             


Leu Thr Ser Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
    130                 135                 140                 


Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
145                 150                 155                 160 


Val Val Ala Gly Glu Asp Arg Ser Lys Leu Ala Asn Met Asn Ala Thr 
                165                 170                 175     


Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
            180                 185                 190         


Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
        195                 200                 205             


Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Val Leu Leu Trp 
    210                 215                 220                 


Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Gly Leu Lys 
225                 230                 235                 240 


Glu Glu Glu Thr Glu Leu Lys Gln Leu Asn Leu His Lys Asp Thr Glu 
                245                 250                 255     


Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Ile His Glu Leu Glu His Glu Gln Glu Pro Thr Cys Ala Ser Gln Met 
        275                 280                 285             


Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
    290                 295                 300                 


Gln Pro Val Phe Leu Ala Gly Met Gly Leu Ala Phe Leu Tyr Met Thr 
305                 310                 315                 320 


Val Leu Gly Phe Asp Cys Ile Thr Thr Gly Tyr Ala Tyr Thr Gln Gly 
                325                 330                 335     


Leu Ser Gly Ser Ile Leu Ser Ile Leu Met Gly Ala Ser Ala Ile Thr 
            340                 345                 350         


Gly Ile Met Gly Thr Val Ala Phe Thr Trp Leu Arg Arg Lys Cys Gly 
        355                 360                 365             


Leu Val Arg Thr Gly Leu Ile Ser Gly Leu Ala Gln Leu Ser Cys Leu 
    370                 375                 380                 


Ile Leu Cys Val Ile Ser Val Phe Met Pro Gly Ser Pro Leu Asp Leu 
385                 390                 395                 400 


Ser Val Ser Pro Phe Glu Asp Ile Arg Ser Arg Phe Ile Gln Gly Glu 
                405                 410                 415     


Ser Ile Thr Pro Thr Lys Ile Pro Glu Ile Thr Thr Glu Ile Tyr Met 
            420                 425                 430         


Ser Asn Gly Ser Asn Ser Ala Asn Ile Val Pro Glu Thr Ser Pro Glu 
        435                 440                 445             


Ser Val Pro Ile Ile Ser Val Ser Leu Leu Phe Ala Gly Val Ile Ala 
    450                 455                 460                 


Ala Arg Ile Gly Leu Trp Ser Phe Asp Leu Thr Val Thr Gln Leu Leu 
465                 470                 475                 480 


Gln Glu Asn Val Ile Glu Ser Glu Arg Gly Ile Ile Asn Gly Val Gln 
                485                 490                 495     


Asn Ser Met Asn Tyr Leu Leu Asp Leu Leu His Phe Ile Met Val Ile 
            500                 505                 510         


Leu Ala Pro Asn Pro Glu Ala Phe Gly Leu Leu Val Leu Ile Ser Val 
        515                 520                 525             


Ser Phe Val Ala Met Gly His Ile Met Tyr Phe Arg Phe Ala Gln Asn 
    530                 535                 540                 


Thr Leu Gly Asn Lys Leu Phe Ala Cys Gly Pro Asp Ala Lys Glu Val 
545                 550                 555                 560 


Arg Lys Glu Asn Gln Ala Asn Thr Ser Val Val 
                565                 570     


<210>  55
<211>  492
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (41)..(295)

<400>  55
atccctgact cggggtcgcc tttggagcag agaggaggca atg gcc acc atg gag         55
                                            Met Ala Thr Met Glu           
                                            1               5             

aac aag gtg atc tgc gcc ctg gtc ctg gtg tcc atg ctg gcc ctc ggc        103
Asn Lys Val Ile Cys Ala Leu Val Leu Val Ser Met Leu Ala Leu Gly           
                10                  15                  20                

acc ctg gcc gag gcc cag aca gag acg tgt aca gtg gcc ccc cgt gaa        151
Thr Leu Ala Glu Ala Gln Thr Glu Thr Cys Thr Val Ala Pro Arg Glu           
            25                  30                  35                    

aga cag aat tgt ggt ttt cct ggt gtc acg ccc tcc cag tgt gca aat        199
Arg Gln Asn Cys Gly Phe Pro Gly Val Thr Pro Ser Gln Cys Ala Asn           
        40                  45                  50                        

aag ggc tgc tgt ttc gac gac acc gtt cgt ggg gtc ccc tgg tgc ttc        247
Lys Gly Cys Cys Phe Asp Asp Thr Val Arg Gly Val Pro Trp Cys Phe           
    55                  60                  65                            

tat cct aat acc atc gac gtc cct cca gaa gag gag tgt gaa ttt tag        295
Tyr Pro Asn Thr Ile Asp Val Pro Pro Glu Glu Glu Cys Glu Phe               
70                  75                  80                                

acacttctgc agggatctgc ctgcatcctg acgcggtgcc gtccccagca cggtgattag      355

tcccagagct cggctgccac ctccaccgga cacctcagac acgcttctgc agctgtgcct      415

cggctcacaa cacagattga ctgctctgac tttgactact caaaattggc ctaaaaatta      475

aaagagatcg atattaa                                                     492


<210>  56
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Thr Met Glu Asn Lys Val Ile Cys Ala Leu Val Leu Val Ser 
1               5                   10                  15      


Met Leu Ala Leu Gly Thr Leu Ala Glu Ala Gln Thr Glu Thr Cys Thr 
            20                  25                  30          


Val Ala Pro Arg Glu Arg Gln Asn Cys Gly Phe Pro Gly Val Thr Pro 
        35                  40                  45              


Ser Gln Cys Ala Asn Lys Gly Cys Cys Phe Asp Asp Thr Val Arg Gly 
    50                  55                  60                  


Val Pro Trp Cys Phe Tyr Pro Asn Thr Ile Asp Val Pro Pro Glu Glu 
65                  70                  75                  80  


Glu Cys Glu Phe 
                


<210>  57
<211>  1131
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (180)..(893)

<400>  57
agtgccccag gagctatgac aagcaaagga acatacttgc ctggagatag cctttgcgat       60

atttaaatgt ccgtggatac agaaatctct gcaggcaagt tgctccagag catattgcag      120

gacaagcctg taacgaatag ttaaattcac ggcatctgga ttcctaatcc ttttccgaa       179

atg gca ggt gtg agt gcc tgt ata aaa tat tct atg ttt acc ttc aac        227
Met Ala Gly Val Ser Ala Cys Ile Lys Tyr Ser Met Phe Thr Phe Asn           
1               5                   10                  15                

ttc ttg ttc tgg cta tgt ggt atc ttg atc cta gca tta gca ata tgg        275
Phe Leu Phe Trp Leu Cys Gly Ile Leu Ile Leu Ala Leu Ala Ile Trp           
            20                  25                  30                    

gta cga gta agc aat gac tct caa gca att ttt ggt tct gaa gat gta        323
Val Arg Val Ser Asn Asp Ser Gln Ala Ile Phe Gly Ser Glu Asp Val           
        35                  40                  45                        

ggc tct agc tcc tac gtt gct gtg gac ata ttg att gct gta ggt gcc        371
Gly Ser Ser Ser Tyr Val Ala Val Asp Ile Leu Ile Ala Val Gly Ala           
    50                  55                  60                            

atc atc atg att ctg ggc ttc ctg gga tgc tgc ggt gct ata aaa gaa        419
Ile Ile Met Ile Leu Gly Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu           
65                  70                  75                  80            

agt cgc tgc atg ctt ctg ttg ttt ttc ata ggc ttg ctt ctg atc ctg        467
Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu           
                85                  90                  95                

ctc ctg cag gtg gcg aca ggt atc cta gga gct gtt ttc aaa tct aag        515
Leu Leu Gln Val Ala Thr Gly Ile Leu Gly Ala Val Phe Lys Ser Lys           
            100                 105                 110                   

tct gat cgc att gtg aat gaa act ctc tat gaa aac aca aag ctt ttg        563
Ser Asp Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu Leu           
        115                 120                 125                       

agc gcc aca ggg gaa agt gaa aaa caa ttc cag gaa gcc ata att gtg        611
Ser Ala Thr Gly Glu Ser Glu Lys Gln Phe Gln Glu Ala Ile Ile Val           
    130                 135                 140                           

ttt caa gaa gag ttt aaa tgc tgc ggt ttg gtc aat gga gct gct gat        659
Phe Gln Glu Glu Phe Lys Cys Cys Gly Leu Val Asn Gly Ala Ala Asp           
145                 150                 155                 160           

tgg gga aat aat ttt caa cac tat cct gaa tta tgt gcc tgt cta gat        707
Trp Gly Asn Asn Phe Gln His Tyr Pro Glu Leu Cys Ala Cys Leu Asp           
                165                 170                 175               

aag cag aga cca tgc caa agc tat aat gga aaa caa gtt tac aaa gag        755
Lys Gln Arg Pro Cys Gln Ser Tyr Asn Gly Lys Gln Val Tyr Lys Glu           
            180                 185                 190                   

acc tgt att tct ttc ata aaa gac ttc ttg gca aaa aat ttg att ata        803
Thr Cys Ile Ser Phe Ile Lys Asp Phe Leu Ala Lys Asn Leu Ile Ile           
        195                 200                 205                       

gtt att gga ata tca ttt gga ctg gca gtt att gag ata ctg ggt ttg        851
Val Ile Gly Ile Ser Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu           
    210                 215                 220                           

gtg ttt tct atg gtc ctg tat tgc cag atc ggg aac aaa tga                893
Val Phe Ser Met Val Leu Tyr Cys Gln Ile Gly Asn Lys                       
225                 230                 235                               

atctgtggat gcatcaacct atcgtcagtc aaaccccttt aaaatgttgc tttggctttg      953

taaatttaaa tatgtaagtg ctatataagt caggagcagc tgtcttttta aaatgtctcg     1013

gctagctaga ccacagatat cttctagaca tattgaacac atttaagatt tgagggatat     1073

aagggaaaat gatatgaatg tgtattttta ctcaaaataa aagtaactgt ttacgttg       1131


<210>  58
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Gly Val Ser Ala Cys Ile Lys Tyr Ser Met Phe Thr Phe Asn 
1               5                   10                  15      


Phe Leu Phe Trp Leu Cys Gly Ile Leu Ile Leu Ala Leu Ala Ile Trp 
            20                  25                  30          


Val Arg Val Ser Asn Asp Ser Gln Ala Ile Phe Gly Ser Glu Asp Val 
        35                  40                  45              


Gly Ser Ser Ser Tyr Val Ala Val Asp Ile Leu Ile Ala Val Gly Ala 
    50                  55                  60                  


Ile Ile Met Ile Leu Gly Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu 
65                  70                  75                  80  


Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu 
                85                  90                  95      


Leu Leu Gln Val Ala Thr Gly Ile Leu Gly Ala Val Phe Lys Ser Lys 
            100                 105                 110         


Ser Asp Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu Leu 
        115                 120                 125             


Ser Ala Thr Gly Glu Ser Glu Lys Gln Phe Gln Glu Ala Ile Ile Val 
    130                 135                 140                 


Phe Gln Glu Glu Phe Lys Cys Cys Gly Leu Val Asn Gly Ala Ala Asp 
145                 150                 155                 160 


Trp Gly Asn Asn Phe Gln His Tyr Pro Glu Leu Cys Ala Cys Leu Asp 
                165                 170                 175     


Lys Gln Arg Pro Cys Gln Ser Tyr Asn Gly Lys Gln Val Tyr Lys Glu 
            180                 185                 190         


Thr Cys Ile Ser Phe Ile Lys Asp Phe Leu Ala Lys Asn Leu Ile Ile 
        195                 200                 205             


Val Ile Gly Ile Ser Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu 
    210                 215                 220                 


Val Phe Ser Met Val Leu Tyr Cys Gln Ile Gly Asn Lys 
225                 230                 235         


<210>  59
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  59
ttgtggagac tatgtgcaag gaaccatctt cccagctccc aatttcaatc ccataatgga       60

tgcccaaatg ctaggaggag cactccaagg atttgactgt                            100


<210>  60
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  60
ctcagagaga cgtggcagga ccagcgagga atccagcctg tccacttcca gaacagtgtt       60

tcccaggccc cgctgagtgg accggacctc tgacacctcc                            100


<210>  61
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  61
gacttttgaa ctaactgggg agacagacaa catatttgtg atagaacggg agggacttct       60

gtattacaac agagccttgg acagggaaac aagatctact                            100


<210>  62
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  62
tttcaggact gcgtgatcgt gcactttgtg tggtaagagg tttgagtagt cctatatgtc       60

acctagggaa cagacattat agcttactag caaatgaata                            100


<210>  63
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  63
gttgccaccc tggggaccac aacatgctgc tcctttgaca atctcttaga agtcggtcct       60

atctgcaaca aggaagacat atggctgcac gttgatgcag                            100


<210>  64
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  64
accaaataac gagctgcacg gccaagagag tcacaattca ggcaacagga gcgacgggcc       60

aggaaagaac accacccttc acaatgaatt tgacacaatt                            100


<210>  65
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  65
ctgctgcccc gagcctgatt cctagtcctg cttctcttcc ctctctcctc cagcctctca       60

cactctcctc agctctctca tctcctggaa ccatggccag                            100


<210>  66
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  66
tggtagcagc agcaatttcc acatcaatgt agaagagtca gtggatggac aggtggtttc       60

ttcccacaag agagaaatct aagtgtctat tgcaggagaa                            100


<210>  67
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  67
agccagtact acaggacaat tgaggagctg cagaacaaga tcctcacagc caccgtggac       60

aatgccaaca tcctgctaca gattgacaat gcccgtctgg                            100


<210>  68
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  68
agaagatcac ccacaaccca tttggtcccg gacagttctt tgatctgtcc attcgctgtg       60

gcttggatcg cttcaaggtt tacgccaatg gccagcacct                            100


<210>  69
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  69
cggcagagaa caaatgccaa gaactgttgt gcaagtgtga ccaggagatt gctaactgct       60

tagcccaaac tgagtacaac ttaaagtacc tcttctaccc                            100


<210>  70
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  70
tcctgggctt cgtctactcc tttctgggtc ctaacccttt tgtcgcctgg atgcacttcc       60

tggtcttcct cgtgggccgt gtggcacaca ccgtggccta                            100


<210>  71
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  71
aacccaggag tttcaaagaa gcgctagtaa ggtctctgag atccttgcac tagctacatc       60

ctcagggtag gaggaagatg gcttccagaa gcatgcggct                            100


<210>  72
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  72
ttttcctggc actcatcact gtcatgtgca atgacttctt ccagggctgc ccagaccgac       60

cctgaagcag aactcttgac ttcctgccat ggatctcttg                            100


<210>  73
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  73
cggtgccgtc cccagcacgg tgattagtcc cagagctcgg ctgccacctc caccggacac       60

ctcagacacg cttctgcagc tgtgcctcgg ctcacaacac                            100


<210>  74
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  74
ctggctatgt ggtatcttga tcctagcatt agcaatatgg gtacgagtaa gcaatgactc       60

tcaagcaatt tttggttctg aagatgtagg ctctagctcc                            100


<210>  75
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  75
tttgtggcaa aaatacttcc taggtggtgc tgggtacttc ttgttgcatc ctgtcaggag       60

gcagataatg ctggtgcctc tctattggta atgttaagac                            100


<210>  76
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  76
atgatggcaa aaccccagga gcagttaatg cctgtcattt atcctgcagt gctttgctgc       60

aagataacat cgctgatgct gtagcttgtg caaagagggt                            100


<210>  77
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  77
cagttctgca atcagcaccc tttcaacaac tcctgttgac accagcacac ctgtgaccaa       60

ttctactgaa gcccgttcat ctcctacaac ttctgaaggt                            100


<210>  78
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  78
catctcctct tggtttcggg gaaacatgca aaagaaatgc tatgggaaga taaaggcatc       60

cgtgttattg atccaggctt ttgtgagagg gtggaaggcc                            100


<210>  79
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  79
gcaattcgcc attactctga agtcctacat tgaatgcaat cggccccagc ctgctcatag       60

gttcttgttc ctgaagatca tggctatgct caccgagctc                            100


<210>  80
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  80
cttgctgaac tgtgaagaac tgcatgaact atatttaagc tgctttctgt accattgcca       60

atcacctttt tggagttgga agtgctattt tcctatggac                            100


<210>  81
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  81
gcaaaggtgc acaagtcaat cagacagaga gatatgagaa attcaaccag attttaactg       60

ccctctcgcg taaattggaa cctcctcctg taaagcaggc                            100


<210>  82
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  82
gacagtggcg actgcgctga cagaacgtga ttctcgtgcc tttattttga aagagatgtt       60

tttcccaaga ggcttgctga aagagtgaga gaagatggaa                            100


<210>  83
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  83
aactctccga agagttgttc caaatgcttt acccggcaac caccagtaaa ggaacgaccc       60

acagttacgg atactcgttc tggctcatac tgctcgtcat                            100


<210>  84
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  84
gaaagtcctc acatcaatag tacatatgaa agtgacctcc aaggggattg gtgaatactc       60

ataaggatct tcaggctgaa cagactatgt ctggggaaag                            100


<210>  85
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  85
tccacagaga ggaggggacc aattctggac agacagatgt tgggaggata cagaggagat       60

gccacttctc actcaccact accagccagc ctcagaaggc                            100


<210>  86
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  86
tgtggcaatg ggccacatta tgtatttccg atttgcccaa aatactctgg gaaacaagct       60

ctttgcttgc ggtcctgatg caaaagaagt taggaaggaa                            100


<210>  87
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  87
ctggttctct tgctccacca ggaacaagcc accatgtctc gccagtcaag tgtgtccttc       60

cggagcgggg gcagtcgtag cttcagcacc gcctctgcca                            100


<210>  88
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  88
ggaggagtcg gacgaggata tgggatttgg tctctttgac taatcaccaa aaagcaacca       60

acttagccag ttttatttgc aaaacaagga aataaaggct                            100


<210>  89
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  89
tactgaagaa tggagagaga attgaaaaag tggagcattc agacttgtct ttcagcaagg       60

actggtcttt ctatctcttg tactacactg aattcacccc                            100


<210>  90
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  90
ttaatagtca ttccaaatat gagatgcgtt gttacaggaa gtcccttgcc atcctaaaag       60

ccaccccact tctctctaag gagaatggcc cagtcctctc                            100


<210>  91
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  91
atgcccgaat gccagagaag gtcacatgga tgaggagaat gaggattttg cgccggctgc       60

tcagaagata ccgtgaatct aagaagatcg atcgccacat                            100


<210>  92
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  92
actgaatctc ccctcctcac agttgccatg tagacccctt gaagagggga ggggcctagg       60

gagccgcacc ttgtcatgta ccatcaataa agtaccctgt                            100


<210>  93
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  93
gtccttgggg aacatggaga ttccagtgtg cctgtatgga gtggaatgaa tgttgctggt       60

gtctctctga agactctgca cccagattta gggactgata                            100


<210>  94
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  94
agattcagct agtggccaag agatgcagtg ccaggaaccc ttaaacagtt gcacagcatc       60

tcagctcatc ttcactgcac cctggatttg catacattct                            100


<210>  95
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  95
ttctaagtat gtccatttcc catctcagct tcaagggagg tgtcagcagt attatctcca       60

ctttcaatct ccctccaagc tctactctgg aggagtctgt                            100


<210>  96
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  96
tcggtacatg gtgccaaccg cctcggggca aactcgctct tggacctggt tgtctttggt       60

cgggcatgtg ccctgagcat cgaagagtca tgcaggcctg                            100


<210>  97
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  97
gcgaaagtga tgagtctaaa aaagtagtcc ctccggttcc tctgtttccc cccatgtggc       60

gtcaggaagc gaggcaccgg gcgcactgcg ccccgaattc                            100


<210>  98
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  98
gagcctatag actatcagtt ccctttgggc ggattgttgt ttaacttgta aatgaaaaaa       60

ttctcttaaa ccacagcact attgagtgaa acattgaact                            100


<210>  99
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  99
gtggagtgtg accttgatgt gaccgggatc ccactctgat tgcatccatt tctctgaaag       60

acttgtttgt tctgcttctc ttcatataac tgagctggcc                            100


<210>  100
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  100
ccgatttcat gactgaacag tcaccgacga gagtgctggg gaataaaaag gggatcttca       60

ctcggcagag acaaccaaaa agtgcagcgt tccttttgcg                            100


<210>  101
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  101
gcaggcaaca cagggaacct caggccaggc accacagctc ttccactcac agactctcac       60

aactgcaccc ttgccgggca ccactccact gtatccctcc                            100


<210>  102
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  102
acaagggcaa cgagcgtttc gtttggactt ctcgacttga gtgcccgcct ccttcgccgc       60

cgcctctgca gtcctcagcg cagttatgcc cagttcttcc                            100


