                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  ANTIGENIC MULTIMERIC RESPIRATORY SYNCYTIAL VIRUS POLYPEPTIDES

<130>  01121-0042-00PCT

<150>  US 62/828,302
<151>  2019-04-02

<160>  226   

<170>  PatentIn version 3.5

<210>  1
<211>  297
<212>  PRT
<213>  Human respiratory syncytial virus A


<220>
<221>  misc_feature
<222>  (1)..(297)
<223>  RSV G A strain Native

<400>  1

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Arg Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Cys Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Val Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Val Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Ile Thr Ser Thr Thr Thr Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Asn Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Pro Ser Asn Pro Ser Asp Ile Thr Ser Leu Ile Thr 
            100                 105                 110         


Thr Ile Leu Asp Ser Thr Thr Pro Gly Val Lys Ser Thr Leu Gln Ser 
        115                 120                 125             


Thr Thr Val Gly Thr Lys Asn Thr Thr Thr Thr Gln Ala Gln Pro Asn 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Arg Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Pro 
        195                 200                 205             


Lys Thr Thr Lys Lys Gly Pro Lys Pro Gln Thr Thr Lys Ser Lys Glu 
    210                 215                 220                 


Ala Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Ile Thr Thr Leu Leu Thr Ser Asn Thr Thr Arg Asn Pro 
                245                 250                 255     


Glu Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Pro Ser Pro Ser Gln Val Ser Ile Thr Ser Glu Tyr Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Pro Arg 
    290                 295         


<210>  2
<211>  233
<212>  PRT
<213>  Human respiratory syncytial virus A


<220>
<221>  misc_feature
<222>  (1)..(233)
<223>  RSV G ectodomain, residues 66-297

<400>  2

Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr Ser 
1               5                   10                  15      


Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln Leu 
            20                  25                  30          


Gly Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr Thr 
        35                  40                  45              


Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro Thr 
    50                  55                  60                  


Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser Lys 
65                  70                  75                  80  


Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn 
                85                  90                  95      


Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser 
            100                 105                 110         


Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys 
        115                 120                 125             


Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe Lys 
    130                 135                 140                 


Thr Thr Lys Lys Asp His Lys Pro Gln Thr Thr Lys Pro Lys Glu Val 
145                 150                 155                 160 


Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys Thr 
                165                 170                 175     


Asn Ile Ile Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro Lys 
            180                 185                 190         


Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly Asn 
        195                 200                 205             


Leu Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln Pro 
    210                 215                 220                 


Ser Ser Pro Pro Asn Thr Thr Arg Gln 
225                 230             


<210>  3
<211>  43
<212>  PRT
<213>  Human respiratory syncytial virus A


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  RSV Gcc (central conserved region) A2 strain res 151-193. As 
       described in Murata et al. (2010) Vaccine 28:6242-6246 at Fig. 1.

<400>  3

Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn Asp Phe His Phe Glu 
1               5                   10                  15      


Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys 
            20                  25                  30          


Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys 
        35                  40              


<210>  4
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV Gcc B1-A2-foldon strain chimera sequence

<400>  4

Met Glu Glu Ser Glu Glu Ser Gly Gly Arg Lys Asn Pro Pro Lys Lys 
1               5                   10                  15      


Pro Lys Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser 
            20                  25                  30          


Ile Cys Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro 
        35                  40                  45              


Asn Lys Lys Glu Glu Glu Glu Glu Ser Glu Glu Ser Gly Gly Arg Gln 
    50                  55                  60                  


Asn Lys Pro Pro Ser Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe 
65                  70                  75                  80  


Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala 
                85                  90                  95      


Ile Cys Lys Arg Ile Pro Asn Lys Lys Glu Glu Glu Ser Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Ser Ser Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
    130                 135                 140                 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
145                 150                 155                 160 


Leu Gly Ser Gly Leu Glu Val Leu Phe Gln Gly Pro Leu Glu His His 
                165                 170                 175     


His His His His 
            180 


<210>  5
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV Gcc tetramer, A2-B1-A2-B1 strain chimera

<400>  5

Met Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn Asn Asp Phe His Phe 
1               5                   10                  15      


Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr 
            20                  25                  30          


Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Arg Lys Asn Pro Pro 
        35                  40                  45              


Lys Lys Pro Lys Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro 
    50                  55                  60                  


Cys Ser Ile Cys Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr 
65                  70                  75                  80  


Ile Pro Asn Lys Lys Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn Asn 
                85                  90                  95      


Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser 
            100                 105                 110         


Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Arg 
        115                 120                 125             


Lys Asn Pro Pro Lys Lys Pro Lys Asp Asp Tyr His Phe Glu Val Phe 
    130                 135                 140                 


Asn Phe Val Pro Cys Ser Ile Cys Gly Asn Asn Gln Leu Cys Lys Ser 
145                 150                 155                 160 


Ile Cys Lys Thr Ile Pro Asn Lys Lys 
                165                 


<210>  6
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV Gcc A2-?-B1 chimera particle

<400>  6

Met Glu Glu Ser Glu Glu Ser Gly Gly Arg Gln Asn Lys Pro Pro Ser 
1               5                   10                  15      


Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys 
            20                  25                  30          


Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile 
        35                  40                  45              


Pro Asn Lys Glu Glu Glu Glu Glu Ser Glu Glu Ser Gly Gly Ser Gly 
    50                  55                  60                  


Ser Trp Glu Glu Trp Asn Ala Lys Trp Asp Glu Trp Arg Asn Asp Gln 
65                  70                  75                  80  


Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg Asp Asp Trp Ala Tyr 
                85                  90                  95      


Trp Thr Leu Thr Trp Arg Tyr Gly Glu Leu Tyr Ser Arg Leu Ala Arg 
            100                 105                 110         


Ile Glu Arg Arg Val Glu Glu Leu Arg Arg Leu Leu Gln Leu Ile Arg 
        115                 120                 125             


His Glu Asn Arg Met Val Leu Gln Phe Val Arg Ala Leu Ser Met Gln 
    130                 135                 140                 


Ala Arg Arg Leu Glu Ser Lys Leu Glu Glu Glu Glu Glu Ser Glu Glu 
145                 150                 155                 160 


Ser Gly Gly Arg Lys Asn Pro Pro Lys Lys Pro Lys Asp Asp Tyr His 
                165                 170                 175     


Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Gly Asn Asn Gln 
            180                 185                 190         


Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro Asn Lys Lys Glu Glu Ser 
        195                 200                 205             


Glu Glu Ser Gly Gly 
    210             


<210>  7
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV Gcc A2-A2-foldon strain chimera sequence

<400>  7

Met Glu Glu Ser Glu Glu Ser Gly Gly Arg Gln Asn Lys Pro Pro Ser 
1               5                   10                  15      


Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys 
            20                  25                  30          


Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile 
        35                  40                  45              


Pro Asn Lys Lys Glu Glu Glu Glu Glu Ser Glu Glu Ser Gly Gly Arg 
    50                  55                  60                  


Gln Asn Lys Pro Pro Ser Lys Pro Asn Asn Asp Phe His Phe Glu Val 
65                  70                  75                  80  


Phe Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp 
                85                  90                  95      


Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys Glu Glu Glu Ser Ser Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Ser Ser Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    130                 135                 140                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
145                 150                 155                 160 


Phe Leu Gly Ser Gly Leu Glu Val Leu Phe Gln Gly Pro Leu Glu His 
                165                 170                 175     


His His His His His 
            180     


<210>  8
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV Gcc B1-B1-foldon strain chimera sequence

<400>  8

Met Glu Glu Ser Glu Glu Ser Gly Gly Arg Lys Asn Pro Pro Lys Lys 
1               5                   10                  15      


Pro Lys Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser 
            20                  25                  30          


Ile Cys Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro 
        35                  40                  45              


Asn Lys Lys Glu Glu Glu Glu Glu Ser Glu Glu Ser Gly Gly Arg Lys 
    50                  55                  60                  


Asn Pro Pro Lys Lys Pro Lys Asp Asp Tyr His Phe Glu Val Phe Asn 
65                  70                  75                  80  


Phe Val Pro Cys Ser Ile Cys Gly Asn Asn Gln Leu Cys Lys Ser Ile 
                85                  90                  95      


Cys Lys Thr Ile Pro Asn Lys Lys Glu Glu Glu Ser Ser Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Ser Ser Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
    130                 135                 140                 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
145                 150                 155                 160 


Gly Ser Gly Leu Glu Val Leu Phe Gln Gly Pro Leu Glu His His His 
                165                 170                 175     


His His His 
            


<210>  9
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: alpha- sequence

<400>  9

Asp Glu Trp Arg Asn Asp Gln Asn Asp Trp Arg Glu Asp Trp Gln Ala 
1               5                   10                  15      


Trp Arg Asp Asp Trp Ala Tyr Trp Thr Leu Thr Trp Arg Tyr Gly Glu 
            20                  25                  30          


Leu Tyr Ser Arg Leu Ala Arg Ile Glu Arg Arg Val Glu Glu Leu Arg 
        35                  40                  45              


Arg Leu Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe 
    50                  55                  60                  


Val Arg Ala Leu Ser Met Gln Ala Arg Arg 
65                  70                  


<210>  10
<211>  40
<212>  PRT
<213>  Human respiratory syncytial virus B


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  RSV Gcc (central conserved region) B1 strain res 151-193. As 
       described in Murata et al. (2010) Vaccine 28:6242-6246 at Fig. 1.

<400>  10

Arg Leu Lys Asn Pro Pro Lys Lys Pro Lys Asp Asp Tyr His Phe Glu 
1               5                   10                  15      


Val Phe Asn Phe Val Pro Cys Ser Ile Cys Gly Asn Asn Gln Leu Cys 
            20                  25                  30          


Lys Ser Ile Cys Lys Thr Ile Pro 
        35                  40  


<210>  11
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Foldon

<400>  11

Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
1               5                   10                  15      


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser 
            20                  25                  30          


Gly Leu Glu Val Leu Phe Gln Gly Pro Leu Glu 
        35                  40              


<210>  12
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV G peptide A2 (aa 151-193) for conjugation with 
       N-terminal Azido linker and flanking glutamates


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Azido-PEG4 at 5' end

<400>  12

Ser Gly Gly Ser Ser Gly Ser Ser Glu Glu Glu Gly Gly Ser Arg Gln 
1               5                   10                  15      


Asn Lys Pro Pro Asn Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe 
            20                  25                  30          


Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala 
        35                  40                  45              


Ile Cys Lys Arg Ile Pro Asn Lys Lys Glu Glu Glu 
    50                  55                  60  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 30 amino acid foldon

<400>  13

Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
1               5                   10                  15      


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25                  30  


<210>  14
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RSV Gcc B1-A2-30 aa foldon strain chimera sequence

<400>  14

Met Glu Glu Ser Glu Glu Ser Gly Gly Arg Lys Asn Pro Pro Lys Lys 
1               5                   10                  15      


Pro Lys Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser 
            20                  25                  30          


Ile Cys Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro 
        35                  40                  45              


Asn Lys Lys Glu Glu Glu Glu Glu Ser Glu Glu Ser Gly Gly Arg Gln 
    50                  55                  60                  


Asn Lys Pro Pro Ser Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe 
65                  70                  75                  80  


Asn Phe Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala 
                85                  90                  95      


Ile Cys Lys Arg Ile Pro Asn Lys Lys Glu Glu Glu Ser Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Ser Ser Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
    130                 135                 140                 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
145                 150                 155                 160 


Leu 
    


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  15

Gly Gly Gly Ser 
1               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  16

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  17

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65

<400>  65
000

<210>  66

<400>  66
000

<210>  67

<400>  67
000

<210>  68

<400>  68
000

<210>  69

<400>  69
000

<210>  70

<400>  70
000

<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin-N19Q/C31S/S26C

<400>  201

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Cys 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  202
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin-N19Q/C31S/S72C

<400>  202

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Cys Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  203
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin-N19Q/C31S/A75C

<400>  203

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Cys Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  204
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin- N19Q/C31S/K79C

<400>  204

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Cys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  205
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin-N19Q/C31S/S100C

<400>  205

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Cys Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  206
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin-N19Q/C31S/S111C

<400>  206

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Cys Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  207
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: bfpFerritin-N19Q/C31S/E12C

<400>  207

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Cys Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Ser Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  208
<211>  173
<212>  PRT
<213>  Helicobacter pylori J99


<220>
<221>  misc_feature
<222>  (1)..(173)
<223>  Exemplary H. pylori Ferritin with bullfrog linker

<400>  208

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  209
<211>  166
<212>  PRT
<213>  Helicobacter pylori J99


<220>
<221>  misc_feature
<222>  (1)..(166)
<223>  Exemplary wild-type H. pylori ferritin (without bullfrog linker 
       or N-terminal Met)

<400>  209

Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu 
1               5                   10                  15      


Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr 
            20                  25                  30          


His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu 
        35                  40                  45              


Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn 
    50                  55                  60                  


Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu 
65                  70                  75                  80  


Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile 
                85                  90                  95      


Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp 
            100                 105                 110         


His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu 
        115                 120                 125             


Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly 
    130                 135                 140                 


Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile 
145                 150                 155                 160 


Ala Lys Ser Arg Lys Ser 
                165     


<210>  210
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CpG (ISS-1018)

<400>  210
tgactgtgaa cgttcgagat ga                                                22


<210>  211
<211>  191
<212>  PRT
<213>  Trichoplusia ni


<220>
<221>  misc_feature
<222>  (1)..(191)
<223>  Trichoplusia ni heavy chain ferritin

<400>  211

Thr Gln Cys Asn Val Asn Pro Val Gln Ile Pro Lys Asp Trp Ile Thr 
1               5                   10                  15      


Met His Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu 
            20                  25                  30          


Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys 
        35                  40                  45              


Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala 
    50                  55                  60                  


Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met 
65                  70                  75                  80  


Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro 
                85                  90                  95      


Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala 
            100                 105                 110         


Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys 
        115                 120                 125             


Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr 
    130                 135                 140                 


Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu 
145                 150                 155                 160 


Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala 
                165                 170                 175     


Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
            180                 185                 190     


<210>  212
<211>  212
<212>  PRT
<213>  Trichoplusia ni


<220>
<221>  misc_feature
<222>  (1)..(212)
<223>  Trichoplusia ni light chain ferritin

<400>  212

Ala Asp Thr Cys Tyr Asn Asp Val Ala Leu Asp Cys Gly Ile Thr Ser 
1               5                   10                  15      


Asn Ser Leu Ala Leu Pro Arg Cys Asn Ala Val Tyr Gly Glu Tyr Gly 
            20                  25                  30          


Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His 
        35                  40                  45              


Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn 
    50                  55                  60                  


Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser 
65                  70                  75                  80  


Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys 
                85                  90                  95      


Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu 
            100                 105                 110         


Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys 
        115                 120                 125             


Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His 
    130                 135                 140                 


Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala 
145                 150                 155                 160 


Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg 
                165                 170                 175     


Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn 
            180                 185                 190         


Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu 
        195                 200                 205             


Gln Lys Thr Val 
    210         


<210>  213
<211>  174
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  misc_feature
<222>  (1)..(174)
<223>  Pyrococcus furiosus ferritin

<400>  213

Met Leu Ser Glu Arg Met Leu Lys Ala Leu Asn Asp Gln Leu Asn Arg 
1               5                   10                  15      


Glu Leu Tyr Ser Ala Tyr Leu Tyr Phe Ala Met Ala Ala Tyr Phe Glu 
            20                  25                  30          


Asp Leu Gly Leu Glu Gly Phe Ala Asn Trp Met Lys Ala Gln Ala Glu 
        35                  40                  45              


Glu Glu Ile Gly His Ala Leu Arg Phe Tyr Asn Tyr Ile Tyr Asp Arg 
    50                  55                  60                  


Asn Gly Arg Val Glu Leu Asp Glu Ile Pro Lys Pro Pro Lys Glu Trp 
65                  70                  75                  80  


Glu Ser Pro Leu Lys Ala Phe Glu Ala Ala Tyr Glu His Glu Lys Phe 
                85                  90                  95      


Ile Ser Lys Ser Ile Tyr Glu Leu Ala Ala Leu Ala Glu Glu Glu Lys 
            100                 105                 110         


Asp Tyr Ser Thr Arg Ala Phe Leu Glu Trp Phe Ile Asn Glu Gln Val 
        115                 120                 125             


Glu Glu Glu Ala Ser Val Lys Lys Ile Leu Asp Lys Leu Lys Phe Ala 
    130                 135                 140                 


Lys Asp Ser Pro Gln Ile Leu Phe Met Leu Asp Lys Glu Leu Ser Ala 
145                 150                 155                 160 


Arg Ala Pro Lys Leu Pro Gly Leu Leu Met Gln Gly Gly Glu 
                165                 170                 


<210>  214
<211>  183
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(183)
<223>  human heavy chain ferritin

<400>  214

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Gln 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Gln Glu Ser 
            180             


<210>  215
<211>  204
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(204)
<223>  human light chain ferritin

<400>  215

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala Ser Ser 
            20                  25                  30          


Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser 
        35                  40                  45              


Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly 
    50                  55                  60                  


Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe 
65                  70                  75                  80  


Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu 
                85                  90                  95      


Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys 
            100                 105                 110         


Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala 
        115                 120                 125             


Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His 
    130                 135                 140                 


Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu 
145                 150                 155                 160 


Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp 
                165                 170                 175     


His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly 
            180                 185                 190         


Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
        195                 200                 


<210>  216
<211>  154
<212>  PRT
<213>  Aquifex aeolicus


<220>
<221>  misc_feature
<222>  (1)..(154)
<223>  lumazine synthase from Aquifex aeolicus

<400>  216

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Cys Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asn Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  217
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Bullfrog linker

<400>  217

Glu Ser Gln Val Arg Gln Gln Phe 
1               5               


<210>  218
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cysteine-Thrombin-His Linker

<400>  218

Cys Leu Val Pro Arg Gly Ser Leu Glu His His His His His His 
1               5                   10                  15  


<210>  219
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: E. coli 6,7-dimethyl-8-ribityllumazine synthase

<400>  219

Met Asn Ile Ile Glu Ala Asn Val Ala Thr Pro Asp Ala Arg Val Ala 
1               5                   10                  15      


Ile Thr Ile Ala Arg Phe Asn Asn Phe Ile Asn Asp Ser Leu Leu Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Leu Lys Arg Ile Gly Gln Val Lys Asp Glu Asn 
        35                  40                  45              


Ile Thr Val Val Trp Val Pro Gly Ala Tyr Glu Leu Pro Leu Ala Ala 
    50                  55                  60                  


Gly Ala Leu Ala Lys Thr Gly Lys Tyr Asp Ala Val Ile Ala Leu Gly 
65                  70                  75                  80  


Thr Val Ile Arg Gly Gly Thr Ala His Phe Glu Tyr Val Ala Gly Gly 
                85                  90                  95      


Ala Ser Asn Gly Leu Ala His Val Ala Gln Asp Ser Glu Ile Pro Val 
            100                 105                 110         


Ala Phe Gly Val Leu Thr Thr Glu Ser Ile Glu Gln Ala Ile Glu Arg 
        115                 120                 125             


Ala Gly Thr Lys Ala Gly Asn Lys Gly Ala Glu Ala Ala Leu Thr Ala 
    130                 135                 140                 


Leu Glu Met Ile Asn Val Leu Lys Ala Ile Lys Ala 
145                 150                 155     


<210>  220
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 16 amino acid linker

<400>  220

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  221
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 28 amino acid linker

<400>  221

Gly Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25              


<210>  222
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 46 amino acid linker

<400>  222

Gly Gly Ser Gly Ser Ala Ser Ser Gly Ala Ser Ala Ser Gly Ser Ser 
1               5                   10                  15      


Asn Gly Ser Gly Ser Gly Ser Gly Ser Asn Ser Ser Ala Ser Ser Gly 
            20                  25                  30          


Ala Ser Ser Gly Gly Ala Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40                  45      


<210>  223
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FR1

<400>  223

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Gly Gly Ser Gly Gly Ser Gly 
            20                  25      


<210>  224
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FR2

<400>  224

Gly Gly Ser Gly Ser Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30          


<210>  225

<400>  225
000

<210>  226
<211>  299
<212>  PRT
<213>  Human respiratory syncytial virus B


<220>
<221>  misc_feature
<222>  (1)..(299)
<223>  RSV G B strain Native

<400>  226

Met Ser Lys His Lys Asn Gln Arg Thr Ala Arg Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Ile Val Ile Ser Ser Cys Leu Tyr Arg 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Ala Leu Ser Val Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Ala Ala Ile Ile Phe Ile Ile Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Val Thr Val Gln Thr Ile Lys 
65                  70                  75                  80  


Asn His Thr Glu Lys Asn Ile Thr Thr Tyr Leu Thr Gln Val Pro Pro 
                85                  90                  95      


Glu Arg Val Ser Ser Ser Lys Gln Pro Thr Thr Thr Ser Pro Ile His 
            100                 105                 110         


Thr Asn Ser Ala Thr Thr Ser Pro Asn Thr Lys Ser Glu Thr His His 
        115                 120                 125             


Thr Thr Ala Gln Thr Lys Gly Arg Thr Thr Thr Ser Thr Gln Thr Asn 
    130                 135                 140                 


Lys Pro Ser Thr Lys Pro Arg Leu Lys Asn Pro Pro Lys Lys Pro Lys 
145                 150                 155                 160 


Asp Asp Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Gly Asn Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro Ser Asn 
            180                 185                 190         


Lys Pro Lys Lys Lys Pro Thr Ile Lys Pro Thr Asn Lys Pro Thr Thr 
        195                 200                 205             


Lys Thr Thr Asn Lys Arg Asp Pro Lys Thr Pro Ala Lys Thr Thr Lys 
    210                 215                 220                 


Lys Glu Thr Thr Thr Asn Pro Thr Lys Lys Pro Thr Leu Thr Thr Thr 
225                 230                 235                 240 


Glu Arg Asp Thr Ser Thr Ser Gln Ser Thr Val Leu Asp Thr Thr Thr 
                245                 250                 255     


Leu Glu His Thr Ile Gln Gln Gln Ser Leu His Ser Thr Thr Pro Glu 
            260                 265                 270         


Asn Thr Pro Asn Ser Thr Gln Thr Pro Thr Ala Ser Glu Pro Ser Thr 
        275                 280                 285             


Ser Asn Ser Thr Gln Asn Thr Gln Ser His Ala 
    290                 295                 


