                         SEQUENCE LISTING

<110>  The General Hospital Corporation
       President and Fellows of Harvard College
 
<120>  METHODS TO ENHANCE T CELL REGENERATION

<130>  51395-002WO3

<150>  US 62/945,290
<151>  2019-12-09

<150>  US 62/828,384
<151>  2019-04-02

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Leu Gln Gln Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys 
1               5                   10                  15      


Lys Asn Trp Tyr Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu 
            20                  25                  30          


Tyr Glu Cys Cys Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys 
        35                  40                  45              


Pro Ala Val Leu Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val 
    50                  55                  60                  


Gly Ala Thr Thr Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu 
65                  70                  75                  80  


Glu Ile Glu Gly Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu 
                85                  90                  95      


Ala Trp Asp Asn Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn 
            100                 105                 110         


Val Asn Val Glu Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys 
        115                 120                 125             


Arg Met Leu Thr Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met 
    130                 135                 140                 


Tyr Asn Asn Leu Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val 
145                 150                 155                 160 


Thr Val Asn Cys Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn 
                165                 170                 175     


Gly Val Val His Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser 
            180                 185                 190         


Ile Gln Asp Phe Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala 
        195                 200                 205             


Ala Ala Ile Thr Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His 
    210                 215                 220                 


Phe Thr Leu Phe Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg 
225                 230                 235                 240 


Gly Val Leu Glu Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu 
                245                 250                 255     


Met Lys Tyr His Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met 
            260                 265                 270         


Gly Gly Ala Val Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly 
        275                 280                 285             


Cys Asp Gly Asp Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys 
    290                 295                 300                 


Lys Asp Ile Val Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val 
305                 310                 315                 320 


Leu Ile Pro Asp Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln 
                325                 330                 335     


Gln Thr Thr Phe Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala 
            340                 345                 350         


Leu Arg Pro Asp Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala 
        355                 360                 365             


Phe Ser Asp Asp Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile 
    370                 375                 380                 


Leu Gln Asn His Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr 
385                 390                 395                 400 


Asn Gly Gln Ile Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe 
                405                 410                 415     


Val Tyr Arg Thr Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly 
            420                 425                 430         


Ser Lys Gln Gly Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile 
        435                 440                 445             


Lys Pro Ala Glu Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg 
    450                 455                 460                 


Phe Ser Thr Phe Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu 
465                 470                 475                 480 


Leu Thr Gln Pro Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala 
                485                 490                 495     


Phe Lys Gly Met Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys 
            500                 505                 510         


Asn Ala Leu Gln Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe 
        515                 520                 525             


Ile Gly Lys Gly Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr 
    530                 535                 540                 


Gln Gly Ser Lys Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val 
545                 550                 555                 560 


Asn Glu Leu Lys Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val 
                565                 570                 575     


Ile His Val Val Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly 
            580                 585                 590         


Asn Asp Gln Leu Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln 
        595                 600                 605             


Ile Lys Phe Val Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val 
    610                 615                 620                 


Tyr Lys Pro Ile Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro 
625                 630                 635                 640 


Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly 
                645                 650                 655     


Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu 
            660                 665                 670         


Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys 
        675                 680                 685             


Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys 
    690                 695                 700                 


Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys 
705                 710                 715                 720 


Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
                725                 730                 735 


<210>  2
<211>  3130
<212>  DNA
<213>  Homo sapiens

<400>  2
gccagttctc ttcggggact aactgcaacg gagagactca agatgattcc ctttttaccc       60

atgttttctc tactattgct gcttattgtt aaccctataa acgccaacaa tcattatgac      120

aagatcttgg ctcatagtcg tatcaggggt cgggaccaag gcccaaatgt ctgtgccctt      180

caacagattt tgggcaccaa aaagaaatac ttcagcactt gtaagaactg gtataaaaag      240

tccatctgtg gacagaaaac gactgtgtta tatgaatgtt gccctggtta tatgagaatg      300

gaaggaatga aaggctgccc agcagttttg cccattgacc atgtttatgg cactctgggc      360

atcgtgggag ccaccacaac gcagcgctat tctgacgcct caaaactgag ggaggagatc      420

gagggaaagg gatccttcac ttactttgca ccgagtaatg aggcttggga caacttggat      480

tctgatatcc gtagaggttt ggagagcaac gtgaatgttg aattactgaa tgctttacat      540

agtcacatga ttaataagag aatgttgacc aaggacttaa aaaatggcat gattattcct      600

tcaatgtata acaatttggg gcttttcatt aaccattatc ctaatggggt tgtcactgtt      660

aattgtgctc gaatcatcca tgggaaccag attgcaacaa atggtgttgt ccatgtcatt      720

gaccgtgtgc ttacacaaat tggtacctca attcaagact tcattgaagc agaagatgac      780

ctttcatctt ttagagcagc tgccatcaca tcggacatat tggaggccct tggaagagac      840

ggtcacttca cactctttgc tcccaccaat gaggcttttg agaaacttcc acgaggtgtc      900

ctagaaagga tcatgggaga caaagtggct tccgaagctc ttatgaagta ccacatctta      960

aatactctcc agtgttctga gtctattatg ggaggagcag tctttgagac gctggaagga     1020

aatacaattg agataggatg tgacggtgac agtataacag taaatggaat caaaatggtg     1080

aacaaaaagg atattgtgac aaataatggt gtgatccatt tgattgatca ggtcctaatt     1140

cctgattctg ccaaacaagt tattgagctg gctggaaaac agcaaaccac cttcacggat     1200

cttgtggccc aattaggctt ggcatctgct ctgaggccag atggagaata cactttgctg     1260

gcacctgtga ataatgcatt ttctgatgat actctcagca tggatcagcg cctccttaaa     1320

ttaattctgc agaatcacat attgaaagta aaagttggcc ttaatgagct ttacaacggg     1380

caaatactgg aaaccatcgg aggcaaacag ctcagagtct tcgtatatcg tacagctgtc     1440

tgcattgaaa attcatgcat ggagaaaggg agtaagcaag ggagaaacgg tgcgattcac     1500

atattccgcg agatcatcaa gccagcagag aaatccctcc atgaaaagtt aaaacaagat     1560

aagcgcttta gcaccttcct cagcctactt gaagctgcag acttgaaaga gctcctgaca     1620

caacctggag actggacatt atttgtgcca accaatgatg cttttaaggg aatgactagt     1680

gaagaaaaag aaattctgat acgggacaaa aatgctcttc aaaacatcat tctttatcac     1740

ctgacaccag gagttttcat tggaaaagga tttgaacctg gtgttactaa cattttaaag     1800

accacacaag gaagcaaaat ctttctgaaa gaagtaaatg atacacttct ggtgaatgaa     1860

ttgaaatcaa aagaatctga catcatgaca acaaatggtg taattcatgt tgtagataaa     1920

ctcctctatc cagcagacac acctgttgga aatgatcaac tgctggaaat acttaataaa     1980

ttaatcaaat acatccaaat taagtttgtt cgtggtagca ccttcaaaga aatccccgtg     2040

actgtctata agccaattat taaaaaatac accaaaatca ttgatggagt gcctgtggaa     2100

ataactgaaa aagagacacg agaagaacga atcattacag gtcctgaaat aaaatacact     2160

aggatttcta ctggaggtgg agaaacagaa gaaactctga agaaattgtt acaagaagag     2220

gtcaccaagg tcaccaaatt cattgaaggt ggtgatggtc atttatttga agatgaagaa     2280

attaaaagac tgcttcaggg agacacaccc gtgaggaagt tgcaagccaa caaaaaagtt     2340

caaggatcta gaagacgatt aagggaaggt cgttctcagt gaaaatccaa aaaccagaaa     2400

aaaatgttta tacaacccta agtcaataac ctgaccttag aaaattgtga gagccaagtt     2460

gacttcagga actgaaacat cagcacaaag aagcaatcat caaataattc tgaacacaaa     2520

tttaatattt ttttttctga atgagaaaca tgagggaaat tgtggagtta gcctcctgtg     2580

gtaaaggaat tgaagaaaat ataacacctt acaccctttt tcatcttgac attaaaagtt     2640

ctggctaact ttggaatcca ttagagaaaa atccttgtca ccagattcat tacaattcaa     2700

atcgaagagt tgtgaactgt tatcccattg aaaagaccga gccttgtatg tatgttatgg     2760

atacataaaa tgcacgcaag ccattatctc tccatgggaa gctaagttat aaaaataggt     2820

gcttggtgta caaaactttt tatatcaaaa ggctttgcac atttctatat gagtgggttt     2880

actggtaaat tatgttattt tttacaacta attttgtact ctcagaatgt ttgtcatatg     2940

cttcttgcaa tgcatatttt ttaatctcaa acgtttcaat aaaaccattt ttcagatata     3000

aagagaatta cttcaaattg agtaattcag aaaaactcaa gatttaagtt aaaaagtggt     3060

ttggacttgg gaacaggact ttatacctct tttactgtaa caagtactca ttaaaggaaa     3120

ttgaatgaaa                                                            3130


<210>  3
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Gly Trp Ala Gly Gly Val Gly Thr Arg Cys 
    770                 775                 780                 


Gln Arg Asn Leu Ser His Ala Gln Ala Gln Ala Leu Leu Ala Gly Arg 
785                 790                 795                 800 


Pro Leu Leu Ser Gly Leu Pro 
                805         


<210>  4
<211>  2856
<212>  DNA
<213>  Homo sapiens

<400>  4
attactgttg gagctacagg gagagaaaca gaggaggaga ctgcaagaga tcattggagg       60

ccgtgggcac gctctttact ccatgtgtgg gacattcatt gcggaataac atcggaggag      120

aagtttccca gagctatggg gacttcccat ccggcgttcc tggtcttagg ctgtcttctc      180

acagggctga gcctaatcct ctgccagctt tcattaccct ctatccttcc aaatgaaaat      240

gaaaaggttg tgcagctgaa ttcatccttt tctctgagat gctttgggga gagtgaagtg      300

agctggcagt accccatgtc tgaagaagag agctccgatg tggaaatcag aaatgaagaa      360

aacaacagcg gcctttttgt gacggtcttg gaagtgagca gtgcctcggc ggcccacaca      420

gggttgtaca cttgctatta caaccacact cagacagaag agaatgagct tgaaggcagg      480

cacatttaca tctatgtgcc agacccagat gtagcctttg tacctctagg aatgacggat      540

tatttagtca tcgtggagga tgatgattct gccattatac cttgtcgcac aactgatccc      600

gagactcctg taaccttaca caacagtgag ggggtggtac ctgcctccta cgacagcaga      660

cagggcttta atgggacctt cactgtaggg ccctatatct gtgaggccac cgtcaaagga      720

aagaagttcc agaccatccc atttaatgtt tatgctttaa aagcaacatc agagctggat      780

ctagaaatgg aagctcttaa aaccgtgtat aagtcagggg aaacgattgt ggtcacctgt      840

gctgttttta acaatgaggt ggttgacctt caatggactt accctggaga agtgaaaggc      900

aaaggcatca caatgctgga agaaatcaaa gtcccatcca tcaaattggt gtacactttg      960

acggtccccg aggccacggt gaaagacagt ggagattacg aatgtgctgc ccgccaggct     1020

accagggagg tcaaagaaat gaagaaagtc actatttctg tccatgagaa aggtttcatt     1080

gaaatcaaac ccaccttcag ccagttggaa gctgtcaacc tgcatgaagt caaacatttt     1140

gttgtagagg tgcgggccta cccacctccc aggatatcct ggctgaaaaa caatctgact     1200

ctgattgaaa atctcactga gatcaccact gatgtggaaa agattcagga aataaggtat     1260

cgaagcaaat taaagctgat ccgtgctaag gaagaagaca gtggccatta tactattgta     1320

gctcaaaatg aagatgctgt gaagagctat acttttgaac tgttaactca agttccttca     1380

tccattctgg acttggtcga tgatcaccat ggctcaactg ggggacagac ggtgaggtgc     1440

acagctgaag gcacgccgct tcctgatatt gagtggatga tatgcaaaga tattaagaaa     1500

tgtaataatg aaacttcctg gactattttg gccaacaatg tctcaaacat catcacggag     1560

atccactccc gagacaggag taccgtggag ggccgtgtga ctttcgccaa agtggaggag     1620

accatcgccg tgcgatgcct ggctaagaat ctccttggag ctgagaaccg agagctgaag     1680

ctggtggctc ccaccctgcg ttctgaactc acggtggctg ctgcagtcct ggtgctgttg     1740

gtgattgtga tcatctcact tattgtcctg gttgtcattt ggaaacagaa accgaggtat     1800

gaaattcgct ggagggtcat tgaatcaatc agcccagatg gacatgaata tatttatgtg     1860

gacccgatgc agctgcctta tgactcaaga tgggagtttc caagagatgg actagtgctt     1920

ggtcgggtct tggggtctgg agcgtttggg aaggtggttg aaggaacagc ctatggatta     1980

agccggtccc aacctgtcat gaaagttgca gtgaagatgc taaaacccac ggccagatcc     2040

agtgaaaaac aagctctcat gtctgaactg aagataatga ctcacctggg gccacatttg     2100

aacattgtaa acttgctggg agcctgcacc aagtcaggcc ccatttacat catcacagag     2160

tattgcttct atggagattt ggtcaactat ttgcataaga atagggatag cttcctgagc     2220

caccacccag agaagccaaa gaaagagctg gatatctttg gattgaaccc tgctgatgaa     2280

agcacacgga gctatgttat tttatctttt gaaaacaatg gtgactacat ggacatgaag     2340

caggctgata ctacacagta tgtccccatg ctagaaagga aagaggtttc taaatattcc     2400

gacatccaga gatcactcta tgatcgtcca gcctcatata agaagaaatc tatgttaggc     2460

tgggctggtg gagttggcac gagatgtcag aggaacctga gtcatgctca ggcccaagcc     2520

ctgttggcag gcagaccact gctttctggc cttccgtgac tatctgaaaa aaatcgtgaa     2580

tggctagagc tactcttcac ttgctgaaca ttttcaaaaa gaattgagaa cttctggatt     2640

aaattgcctt cttcctcgaa aaccctggga cccttccaga tgggactaac tggggaaagt     2700

ggacaagtta caaacaaaga aactcaaagg aaagtcattg gcactgatct ctaagatgct     2760

atcacatgtg attggtggtt gattttatta acaaattata agcaaagtac tacaaaggtg     2820

gctttaaaaa gaaaataaag caattcacag aaacta                               2856


<210>  5
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  6
<211>  2551
<212>  DNA
<213>  Homo sapiens

<400>  6
agtccggggg catcgcgatg ctgctgcgcc tgttgctggc ctgggcggcc gcagggccca       60

cactgggcca ggacccctgg gctgctgagc cccgtgccgc ctgcggcccc agcagctgct      120

acgctctctt cccacggcgc cgcaccttcc tggaggcctg gcgggcctgc cgcgagctgg      180

ggggcgacct ggccactcct cggacccccg aggaggccca gcgtgtggac agcctggtgg      240

gtgcgggccc agccagccgg ctgctgtgga tcgggctgca gcggcaggcc cggcaatgcc      300

agctgcagcg cccactgcgc ggcttcacgt ggaccacagg ggaccaggac acggctttca      360

ccaactgggc ccagccagcc tctggaggcc cctgcccggc ccagcgctgt gtggccctgg      420

aggcaagtgg cgagcaccgc tggctggagg gctcgtgcac gctggctgtc gacggctacc      480

tgtgccagtt tggcttcgag ggcgcctgcc cggcgctgca agatgaggcg ggccaggccg      540

gcccagccgt gtataccacg cccttccacc tggtctccac agagtttgag tggctgccct      600

tcggctctgt ggccgctgtg cagtgccagg ctggcagggg agcctctctg ctctgcgtga      660

agcagcctga gggaggtgtg ggctggtcac gggctgggcc cctgtgcctg gggactggct      720

gcagccctga caacgggggc tgcgaacacg aatgtgtgga ggaggtggat ggtcacgtgt      780

cctgccgctg cactgagggc ttccggctgg cagcagacgg gcgcagttgc gaggacccct      840

gtgcccaggc tccgtgcgag cagcagtgtg agcccggtgg gccacaaggc tacagctgcc      900

actgtcgcct gggtttccgg ccagcggagg atgatccgca ccgctgtgtg gacacagatg      960

agtgccagat tgccggtgtg tgccagcaga tgtgtgtcaa ctacgttggt ggcttcgagt     1020

gttattgtag cgagggacat gagctggagg ctgatggcat cagctgcagc cctgcagggg     1080

ccatgggtgc ccaggcttcc caggacctcg gagatgagtt gctggatgac ggggaggatg     1140

aggaagatga agacgaggcc tggaaggcct tcaacggtgg ctggacggag atgcctggga     1200

tcctgtggat ggagcctacg cagccgcctg actttgccct ggcctataga ccgagcttcc     1260

cagaggacag agagccacag ataccctacc cggagcccac ctggccaccc ccgctcagtg     1320

cccccagggt cccctaccac tcctcagtgc tctccgtcac ccggcctgtg gtggtctctg     1380

ccacgcatcc cacactgcct tctgcccacc agcctcctgt gatccctgcc acacacccag     1440

ctttgtcccg tgaccaccag atccccgtga tcgcagccaa ctatccagat ctgccttctg     1500

cctaccaacc cggtattctc tctgtctctc attcagcaca gcctcctgcc caccagcccc     1560

ctatgatctc aaccaaatat ccggagctct tccctgccca ccagtccccc atgtttccag     1620

acacccgggt cgctggcacc cagaccacca ctcatttgcc tggaatccca cctaaccatg     1680

cccctctggt caccaccctc ggtgcccagc taccccctca agccccagat gcccttgtcc     1740

tcagaaccca ggccacccag cttcccatta tcccaactgc ccagccctct ctgaccacca     1800

cctccaggtc ccctgtgtct cctgcccatc aaatctctgt gcctgctgcc acccagcccg     1860

cagccctccc caccctcctg ccctctcaga gccccactaa ccagacctca cccatcagcc     1920

ctacacatcc ccattccaaa gccccccaaa tcccaaggga agatggcccc agtcccaagt     1980

tggccctgtg gctgccctca ccagctccca cagcagcccc aacagccctg ggggaggctg     2040

gtcttgccga gcacagccag agggatgacc ggtggctgct ggtggcactc ctggtgccaa     2100

cgtgtgtctt tttggtggtc ctgcttgcac tgggcatcgt gtactgcacc cgctgtggcc     2160

cccatgcacc caacaagcgc atcactgact gctatcgctg ggtcatccat gctgggagca     2220

agagcccaac agaacccatg ccccccaggg gcagcctcac aggggtgcag acctgcagaa     2280

ccagcgtgtg atggggtgca gacccccctc atggagtatg gggcgctgga cacatggccg     2340

gggctgcacc agggacccat gggggctgcc cagctggaca gatggcttcc tgctccccag     2400

gcccagccag ggtcctctct caaccactag acttggctct caggaactct gcttcctggc     2460

ccagcgctcg tgaccaagga tacaccaaag cccttaagac ctcagggggc gggtgctggg     2520

gtcttctcca ataaatgggg tgtcaacctt a                                    2551


<210>  7
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  8
<211>  1101
<212>  DNA
<213>  Homo sapiens

<400>  8
cctttcactt tcggtctctg gctgtcaccc ggcttggccc cttccacacc caactggggc       60

aagcctgacc cggcgacagg aggcatgagg ggcccccggc cgaaatgaca gtgctggcgc      120

cagcctggag cccaacaacc tatctcctcc tgctgctgct gctgagctcg ggactcagtg      180

ggacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct gtcaaaatcc      240

gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc aacctgcagg      300

acgaggagct ctgcgggggc ctctggcggc tggtcctggc acagcgctgg atggagcggc      360

tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac acggagatac      420

actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc gtccagacca      480

acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag ccctggatca      540

ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc tcaaccctgc      600

cacccccatg gagtccccgg cccctggagg ccacagcccc gacagccccg cagccccctc      660

tgctcctcct actgctgctg cccgtgggcc tcctgctgct ggccgctgcc tggtgcctgc      720

actggcagag gacgcggcgg aggacacccc gccctgggga gcaggtgccc cccgtcccca      780

gtccccagga cctgctgctt gtggagcact gacctggcca aggcctcatc ctgcggagcc      840

ttaaacaacg cagtgagaca gacatctatc atcccatttt acaggggagg atactgaggc      900

acacagaggg gagtcaccag ccagaggatg catagcctgg acacagagga agttggctag      960

aggccggtcc cttccttggg cccctctcat tccctcccca gaatggaggc aacgccagaa     1020

tccagcaccg gccccattta cccaactctg tacaaagccc ttgtccccat gaaattgtat     1080

ataaatcatc cttttctacc a                                               1101


<210>  9
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  10
<211>  683
<212>  DNA
<213>  Homo sapiens

<400>  10
attcccagcc tcacatcact cacaccttgc atttcacccc tgcatcccag tcgccctgca       60

gcctcacaca gatcctgcac acacccagac agctggcgct cacacattca ccgttggcct      120

gcctctgttc accctccatg gccctgctac tggccctcag cctgctggtt ctctggactt      180

ccccagcccc aactctgagt ggcaccaatg atgctgaaga ctgctgcctg tctgtgaccc      240

agaaacccat ccctgggtac atcgtgagga acttccacta ccttctcatc aaggatggct      300

gcagggtgcc tgctgtagtg ttcaccacac tgaggggccg ccagctctgt gcacccccag      360

accagccctg ggtagaacgc atcatccaga gactgcagag gacctcagcc aagatgaagc      420

gccgcagcag ttaacctatg accgtgcaga gggagcccgg agtccgagtc aagcattgtg      480

aattattacc taacctgggg aaccgaggac cagaaggaag gaccaggctt ccagctcctc      540

tgcaccagac ctgaccagcc aggacagggc ctggggtgtg tgtgagtgtg agtgtgagcg      600

agagggtgag tgtggtcaga gtaaagctgc tccaccccca gattgcaatg ctaccaataa      660

agccgcctgg tgtttacaac taa                                              683


<210>  11
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  12
<211>  3545
<212>  DNA
<213>  Homo sapiens

<400>  12
gccgccgccg ccgtcgccgc cgccggagtc ctcgccccgc cgcgctgcgc ccggctcgcg       60

ctgcgctagt cgctccgctt cccacacccc gccggggact ggcagccgcc gccgcacatc      120

tgccgccaca gcctccgccg gctacccgaa cgttctcggg gccagcgccg agtggatcac      180

cggggaccgc gaggcacccg cgcgccgcag accccgcgcg ggctggagca cccggcagag      240

cgcgccacag cgccgtggcc tctgctgccc gggctgcgcc agagccgcgg acgggcgcgc      300

agagcgccgg ggactccgga gccgatccct agcgccgcga tgcggagcac ctactgcagg      360

agatcggggg cctgggacgc gctggccgag gtgtgatcgg accccaggct agccacaaag      420

ggcacttggc cccagggcta ggagagcgag gggagagcac agccacccgc ctcggcggcc      480

cgggactcgg ctcgactcgc cggagaatgc gcccgaggac gacggggcgc cagagccgcg      540

gtgctttcaa ctggcgagcg cgaatggggg tgcactggag taaggcagag tgatgcgggg      600

gggcaactcg cctggcaccg agatcgccgc cgtgcccttc cctggacccg gcgtcgccca      660

ggatggctgc cccgagccat gggccgcggc ggagctagcg cggagcgccc gaccctcgac      720

ccccgagtcc cggagccggc cccgcgcggg gccacgcgtc cctcgggcgc tggttcctaa      780

ggaggacgac agcaccagct tctcctttct cccttccctt ccctgccccg cactcctccc      840

cctgctcgct gttgttgtgt gtcagcactt ggctggggac ttcttgaact tgcagggaga      900

ataacttgcg caccccactt tgcgccggtg cctttgcccc agcggagcct gcttcgccat      960

ctccgagccc caccgcccct ccactcctcg gccttgcccg acactgagac gctgttccca     1020

gcgtgaaaag agagactgcg cggccggcac ccgggagaag gaggaggcaa agaaaaggaa     1080

cggacattcg gtccttgcgc caggtccttt gaccagagtt tttccatgtg gacgctcttt     1140

caatggacgt gtccccgcgt gcttcttaga cggactgcgg tctcctaaag gtcgaccatg     1200

gtggccggga cccgctgtct tctagcgttg ctgcttcccc aggtcctcct gggcggcgcg     1260

gctggcctcg ttccggagct gggccgcagg aagttcgcgg cggcgtcgtc gggccgcccc     1320

tcatcccagc cctctgacga ggtcctgagc gagttcgagt tgcggctgct cagcatgttc     1380

ggcctgaaac agagacccac ccccagcagg gacgccgtgg tgccccccta catgctagac     1440

ctgtatcgca ggcactcagg tcagccgggc tcacccgccc cagaccaccg gttggagagg     1500

gcagccagcc gagccaacac tgtgcgcagc ttccaccatg aagaatcttt ggaagaacta     1560

ccagaaacga gtgggaaaac aacccggaga ttcttcttta atttaagttc tatccccacg     1620

gaggagttta tcacctcagc agagcttcag gttttccgag aacagatgca agatgcttta     1680

ggaaacaata gcagtttcca tcaccgaatt aatatttatg aaatcataaa acctgcaaca     1740

gccaactcga aattccccgt gaccagactt ttggacacca ggttggtgaa tcagaatgca     1800

agcaggtggg aaagttttga tgtcaccccc gctgtgatgc ggtggactgc acagggacac     1860

gccaaccatg gattcgtggt ggaagtggcc cacttggagg agaaacaagg tgtctccaag     1920

agacatgtta ggataagcag gtctttgcac caagatgaac acagctggtc acagataagg     1980

ccattgctag taacttttgg ccatgatgga aaagggcatc ctctccacaa aagagaaaaa     2040

cgtcaagcca aacacaaaca gcggaaacgc cttaagtcca gctgtaagag acaccctttg     2100

tacgtggact tcagtgacgt ggggtggaat gactggattg tggctccccc ggggtatcac     2160

gccttttact gccacggaga atgccctttt cctctggctg atcatctgaa ctccactaat     2220

catgccattg ttcagacgtt ggtcaactct gttaactcta agattcctaa ggcatgctgt     2280

gtcccgacag aactcagtgc tatctcgatg ctgtaccttg acgagaatga aaaggttgta     2340

ttaaagaact atcaggacat ggttgtggag ggttgtgggt gtcgctagta cagcaaaatt     2400

aaatacataa atatatatat atatatatat tttagaaaaa agaaaaaaac aaacaaacaa     2460

aaaaacccca ccccagttga cactttaata tttcccaatg aagactttat ttatggaatg     2520

gaatggaaaa aaaaacagct attttgaaaa tatatttata tctacgaaaa gaagttggga     2580

aaacaaatat tttaatcaga gaattattcc ttaaagattt aaaatgtatt tagttgtaca     2640

ttttatatgg gttcaacccc agcacatgaa gtataatggt cagatttatt ttgtatttat     2700

ttactattat aaccactttt taggaaaaaa atagctaatt tgtatttata tgtaatcaaa     2760

agaagtatcg ggtttgtaca taattttcca aaaattgtag ttgttttcag ttgtgtgtat     2820

ttaagatgaa aagtctacat ggaaggttac tctggcaaag tgcttagcac gtttgctttt     2880

ttgcagtgct actgttgagt tcacaagttc aagtccagaa aaaaaaagtg gataatccac     2940

tctgctgact ttcaagatta ttatattatt caattctcag gaatgttgca gagtgattgt     3000

ccaatccatg agaatttaca tccttattag gtggaatatt tggataagaa ccagacattg     3060

ctgatctatt atagaaactc tcctcctgcc ccttaattta cagaaagaat aaagcaggat     3120

ccatagaaat aattaggaaa acgatgaacc tgcaggaaag tgaatgatgg tttgttgttc     3180

ttctttccta aattagtgat cccttcaaag gggctgatct ggccaaagta ttcaataaaa     3240

cgtaagattt cttcattatt gatattgtgg tcatatatat ttaaaattga tatctcgtgg     3300

ccctcatcaa gggttggaaa tttatttgtg ttttaccttt acctcatctg agagctcttt     3360

attctccaaa gaacccagtt ttctaacttt ttgcccaaca cgcagcaaaa ttatgcacat     3420

cgtgttttct gcccaccctc tgttctctga cctatcagct tgcttttctt tccaaggttg     3480

tgtgtttgaa cacatttctc caaatgttaa acctatttca gataataaat atcaaatctc     3540

tggca                                                                 3545


<210>  13
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


<210>  14
<211>  1931
<212>  DNA
<213>  Homo sapiens

<400>  14
ggaagatgcg agaaggcaga ggaggaggga gggagggaag gagcgcggag cccggcccgg       60

aagctaggtg agtgtggcat ccgagctgag ggacgcgagc ctgagacgcc gctgctgctc      120

cggctgagta tctagcttgt ctccccgatg ggattcccgt ccaagctatc tcgagcctgc      180

agcgccacag tccccggccc tcgcccaggt tcactgcaac cgttcagagg tccccaggag      240

ctgctgctgg cgagcccgct actgcaggga cctatggagc cattccgtag tgccatcccg      300

agcaacgcac tgctgcagct tccctgagcc tttccagcaa gtttgttcaa gattggctgt      360

caagaatcat ggactgttat tatatgcctt gttttctgtc aagacaccat gattcctggt      420

aaccgaatgc tgatggtcgt tttattatgc caagtcctgc taggaggcgc gagccatgct      480

agtttgatac ctgagacggg gaagaaaaaa gtcgccgaga ttcagggcca cgcgggagga      540

cgccgctcag ggcagagcca tgagctcctg cgggacttcg aggcgacact tctgcagatg      600

tttgggctgc gccgccgccc gcagcctagc aagagtgccg tcattccgga ctacatgcgg      660

gatctttacc ggcttcagtc tggggaggag gaggaagagc agatccacag cactggtctt      720

gagtatcctg agcgcccggc cagccgggcc aacaccgtga ggagcttcca ccacgaagaa      780

catctggaga acatcccagg gaccagtgaa aactctgctt ttcgtttcct ctttaacctc      840

agcagcatcc ctgagaacga ggtgatctcc tctgcagagc ttcggctctt ccgggagcag      900

gtggaccagg gccctgattg ggaaaggggc ttccaccgta taaacattta tgaggttatg      960

aagcccccag cagaagtggt gcctgggcac ctcatcacac gactactgga cacgagactg     1020

gtccaccaca atgtgacacg gtgggaaact tttgatgtga gccctgcggt ccttcgctgg     1080

acccgggaga agcagccaaa ctatgggcta gccattgagg tgactcacct ccatcagact     1140

cggacccacc agggccagca tgtcaggatt agccgatcgt tacctcaagg gagtgggaat     1200

tgggcccagc tccggcccct cctggtcacc tttggccatg atggccgggg ccatgccttg     1260

acccgacgcc ggagggccaa gcgtagccct aagcatcact cacagcgggc caggaagaag     1320

aataagaact gccggcgcca ctcgctctat gtggacttca gcgatgtggg ctggaatgac     1380

tggattgtgg ccccaccagg ctaccaggcc ttctactgcc atggggactg cccctttcca     1440

ctggctgacc acctcaactc aaccaaccat gccattgtgc agaccctggt caattctgtc     1500

aattccagta tccccaaagc ctgttgtgtg cccactgaac tgagtgccat ctccatgctg     1560

tacctggatg agtatgataa ggtggtactg aaaaattatc aggagatggt agtagaggga     1620

tgtgggtgcc gctgagatca ggcagtcctt gaggatagac agatatacac accacacaca     1680

cacaccacat acaccacaca cacacgttcc catccactca cccacacact acacagactg     1740

cttccttata gctggacttt tatttaaaaa aaaaaaaaaa aaaggaaaaa atccctaaac     1800

attcaccttg accttattta tgactttacg tgcaaatgtt ttgaccatat tgatcatata     1860

ttttgacaaa atatatttat aactacgtat taaaagaaaa aaataaaatg agtcattatt     1920

ttaaaggtaa a                                                          1931


<210>  15
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  16
<211>  2015
<212>  DNA
<213>  Homo sapiens

<400>  16
cttttcgcca ggggttggga ctccgggtgg caggcgcccg ggggaatccc agctgactcg       60

ctcactgcct tcgaagtccg gcgccccccg ggagggaact gggtggccgc accctcccgg      120

ctgcggtggc tgtcgccccc caccctgcag ccaggactcg atggagaatc cattccaata      180

tatggccatg tggctctttg gagcaatgtt ccatcatgtt ccatgctgct gacgtcacat      240

ggagcacaga aatcaatgtt agcagatagc cagcccatac aagatcgtat tgtattgtag      300

gaggcattgt ggatggatgg ctgctggaaa ccccttgcca tagccagctc ttcttcaata      360

cttaaggatt taccgtggct ttgagtaatg agaatttcga aaccacattt gagaagtatt      420

tccatccagt gctacttgtg tttacttcta aacagtcatt ttctaactga agctggcatt      480

catgtcttca ttttgggctg tttcagtgca gggcttccta aaacagaagc caactgggtg      540

aatgtaataa gtgatttgaa aaaaattgaa gatcttattc aatctatgca tattgatgct      600

actttatata cggaaagtga tgttcacccc agttgcaaag taacagcaat gaagtgcttt      660

ctcttggagt tacaagttat ttcacttgag tccggagatg caagtattca tgatacagta      720

gaaaatctga tcatcctagc aaacaacagt ttgtcttcta atgggaatgt aacagaatct      780

ggatgcaaag aatgtgagga actggaggaa aaaaatatta aagaattttt gcagagtttt      840

gtacatattg tccaaatgtt catcaacact tcttgattgc aattgattct ttttaaagtg      900

tttctgttat taacaaacat cactctgctg cttagacata acaaaacact cggcatttca      960

aatgtgctgt caaaacaagt ttttctgtca agaagatgat cagaccttgg atcagatgaa     1020

ctcttagaaa tgaaggcaga aaaatgtcat tgagtaatat agtgactatg aacttctctc     1080

agacttactt tactcatttt tttaatttat tattgaaatt gtacatattt gtggaataat     1140

gtaaaatgtt gaataaaaat atgtacaagt gttgtttttt aagttgcact gatattttac     1200

ctcttattgc aaaatagcat ttgtttaagg gtgatagtca aattatgtat tggtggggct     1260

gggtaccaat gctgcaggtc aacagctatg ctggtaggct cctgccagtg tggaaccact     1320

gactactggc tctcattgac ttccttacta agcatagcaa acagaggaag aatttgttat     1380

cagtaagaaa aagaagaact atatgtgaat cctcttcttt atactgtaat ttagttattg     1440

atgtataaag caactgttat gaaataaaga aattgcaata actggcatat aatgtccatc     1500

agtaaatctt ggtggtggtg gcaataataa acttctactg ataggtagaa tggtgtgcaa     1560

gcttgtccaa tcacggattg caggccacat gcggcccagg acaactttga atgtggccca     1620

acacaaattc ataaactttc atacatctcg tttttagctc atcagctatc attagcggta     1680

gtgtatttaa agtgtggccc aagacaattc ttcttattcc aatgtggccc agggaaatca     1740

aaagattgga tgcccctggt atagaaaact aatagtgaca gtgttcatat ttcatgcttt     1800

cccaaataca ggtattttat tttcacattc tttttgccat gtttatataa taataaagaa     1860

aaaccctgtt gatttgttgg agccattgtt atctgacaga aaataattgt ttatattttt     1920

tgcactacac tgtctaaaat tagcaagctc tcttctaatg gaactgtaag aaagatgaaa     1980

tatttttgtt ttattataaa tttatttcac cttaa                                2015


<210>  17
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  18
<211>  1444
<212>  DNA
<213>  Homo sapiens

<400>  18
atttcgcttt cattttgggc cgagctggag gcggcggggc cgtcccggaa cggctgcggc       60

cgggcacccc gggagttaat ccgaaagcgc cgcaagcccc gcgggccggc cgcaccgcac      120

gtgtcaccga gaagctgatg tagagagaga cacagaagga gacagaaagc aagagaccag      180

agtcccggga aagtcctgcc gcgcctcggg acaattataa aaatgtggcc ccctgggtca      240

gcctcccagc caccgccctc acctgccgcg gccacaggtc tgcatccagc ggctcgccct      300

gtgtccctgc agtgccggct cagcatgtgt ccagcgcgca gcctcctcct tgtggctacc      360

ctggtcctcc tggaccacct cagtttggcc agaaacctcc ccgtggccac tccagaccca      420

ggaatgttcc catgccttca ccactcccaa aacctgctga gggccgtcag caacatgctc      480

cagaaggcca gacaaactct agaattttac ccttgcactt ctgaagagat tgatcatgaa      540

gatatcacaa aagataaaac cagcacagtg gaggcctgtt taccattgga attaaccaag      600

aatgagagtt gcctaaattc cagagagacc tctttcataa ctaatgggag ttgcctggcc      660

tccagaaaga cctcttttat gatggccctg tgccttagta gtatttatga agacttgaag      720

atgtaccagg tggagttcaa gaccatgaat gcaaagcttc tgatggatcc taagaggcag      780

atctttctag atcaaaacat gctggcagtt attgatgagc tgatgcaggc cctgaatttc      840

aacagtgaga ctgtgccaca aaaatcctcc cttgaagaac cggattttta taaaactaaa      900

atcaagctct gcatacttct tcatgctttc agaattcggg cagtgactat tgatagagtg      960

atgagctatc tgaatgcttc ctaaaaagcg aggtccctcc aaaccgttgt catttttata     1020

aaactttgaa atgaggaaac tttgatagga tgtggattaa gaactaggga gggggaaaga     1080

aggatgggac tattacatcc acatgatacc tctgatcaag tatttttgac atttactgtg     1140

gataaattgt ttttaagttt tcatgaatga attgctaaga agggaaaata tccatcctga     1200

aggtgttttt cattcacttt aatagaaggg caaatattta taagctattt ctgtaccaaa     1260

gtgtttgtgg aaacaaacat gtaagcataa cttattttaa aatatttatt tatataactt     1320

ggtaatcatg aaagcatctg agctaactta tatttattta tgttatattt attaaattat     1380

ttatcaagtg tatttgaaaa atatttttaa gtgttctaaa aataaaagta ttgaattaaa     1440

gtga                                                                  1444


<210>  19
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg Leu Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr 
1               5                   10                  15      


Thr Ala Arg Val Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro 
            20                  25                  30          


Lys Ile Arg Tyr Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr 
        35                  40                  45              


Pro His Cys Glu Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser 
    50                  55                  60                  


Arg Tyr Arg Gly Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr 
65                  70                  75                  80  


Lys Arg Phe Ile Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val 
                85                  90                  95      


Tyr Glu Glu 
            


<210>  20
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  20
gtggagagag cgcggagaca agcgcagagc gcagcgcacg gccacagaca gccctgggca       60

tccaccgacg gcgcagccgg agccagcaga gccggaaggc gcgccccggg cagagaaagc      120

cgagcagagc tgggtggcgt ctccgggccg ccgctccgac gggccagcgc cctccccatg      180

tccctgctcc cacgccgcgc ccctccggtc agcatgaggc tcctggcggc cgcgctgctc      240

ctgctgctgc tggcgctgta caccgcgcgt gtggacgggt ccaaatgcaa gtgctcccgg      300

aagggaccca agatccgcta cagcgacgtg aagaagctgg aaatgaagcc aaagtacccg      360

cactgcgagg agaagatggt tatcatcacc accaagagcg tgtccaggta ccgaggtcag      420

gagcactgcc tgcaccccaa gctgcagagc accaagcgct tcatcaagtg gtacaacgcc      480

tggaacgaga agcgcagggt ctacgaagaa tagggtgaaa aacctcagaa gggaaaactc      540

caaaccagtt gggagacttg tgcaaaggac tttgcagatt aaaaaaaaaa aaaaaaaaaa      600

aaaaaaaaaa aaaaaaaaaa aaagcctttc tttctcacag gcataagaca caaattatat      660

attgttatga agcacttttt accaacggtc agtttttaca ttttatagct gcgtgcgaaa      720

ggcttccaga tgggagaccc atctctcttg tgctccagac ttcatcacag gctgcttttt      780

atcaaaaagg ggaaaactca tgcctttcct ttttaaaaaa tgcttttttg tatttgtcca      840

tacgtcacta tacatctgag ctttataagc gcccgggagg aacaatgagc ttggtggaca      900

catttcattg cagtgttgct ccattcctag cttgggaagc ttccgcttag aggtcctggc      960

gcctcggcac agctgccacg ggctctcctg ggcttatggc cggtcacagc ctcagtgtga     1020

ctccacagtg gcccctgtag ccgggcaagc aggagcaggt ctctctgcat ctgttctctg     1080

aggaactcaa gtttggttgc cagaaaaatg tgcttcattc ccccctggtt aatttttaca     1140

caccctagga aacatttcca agatcctgtg atggcgagac aaatgatcct taaagaaggt     1200

gtggggtctt tcccaacctg aggatttctg aaaggttcac aggttcaata tttaatgctt     1260

cagaagcatg tgaggttccc aacactgtca gcaaaaacct taggagaaaa cttaaaaata     1320

tatgaataca tgcgcaatac acagctacag acacacattc tgttgacaag ggaaaacctt     1380

caaagcatgt ttctttccct caccacaaca gaacatgcag tactaaagca atatatttgt     1440

gattccccat gtaattcttc aatgttaaac agtgcagtcc tctttcgaaa gctaagatga     1500

ccatgcgccc tttcctctgt acatataccc ttaagaacgc cccctccaca cactgccccc     1560

cagtatatgc cgcattgtac tgctgtgtta tatgctatgt acatgtcaga aaccattagc     1620

attgcatgca ggtttcatat tctttctaag atggaaagta ataaaatata tttgaaatgt     1680

accaaaa                                                               1687


<210>  21
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 
                85                  90                  95      


Pro 
    


<210>  22
<211>  1005
<212>  DNA
<213>  Homo sapiens

<400>  22
agagaggctg agaccaaccc agaaaccacc acctctcacg ccaaagctca caccttcagc       60

ctccaacatg aaggtctccg cagcacttct gtggctgctg ctcatagcag ctgccttcag      120

cccccagggg ctcgctgggc cagcttctgt cccaaccacc tgctgcttta acctggccaa      180

taggaagata ccccttcagc gactagagag ctacaggaga atcaccagtg gcaaatgtcc      240

ccagaaagct gtgatcttca agaccaaact ggccaaggat atctgtgccg accccaagaa      300

gaagtgggtg caggattcca tgaagtatct ggaccaaaaa tctccaactc caaagccata      360

aataatcacc atttttgaaa ccaaaccaga gcctgagtgt tgcctaattt gttttccctt      420

cttacaatgc attctgaggt aacctcatta tcagtccaaa gggcatgggt tttattatat      480

atatatattt ttttttttaa aaaaaaaacg tattgcattt aatttattga ggctttaaaa      540

cttatcctcc atgaatatca gttattttta aactgtaaag ctttgtgcag attctttacc      600

ccctgggagc cccaattcga tcccctgtca cgtgtgggca atgttccccc tctcctctct      660

tcctccctgg aatcttgtaa aggtcctggc aaagatgatc agtatgaaaa tgtcattgtt      720

cttgtgaacc caaagtgtga ctcattaaat ggaagtaaat gttgttttag gaatacataa      780

agtatgtgca tattttatta tagtcactag ttgtaatttt tttgtgggaa atccacactg      840

agctgagggg gacaaagatg gctgtggcca agaggggctt ggttaagggg gtgggaacta      900

tgtccctggg aaatgagttt ttggcttagc tggtcttcat tgaaatgcag ggtgaaactg      960

acaaacccat tccagccctc tattcccatt ttcaacagta tttcc                     1005


<210>  23
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  24
<211>  1175
<212>  DNA
<213>  Homo sapiens

<400>  24
gagacattcc tcaattgctt agacatattc tgagcctaca gcagaggaac ctccagtctc       60

agcaccatga atcaaactgc cattctgatt tgctgcctta tctttctgac tctaagtggc      120

attcaaggag tacctctctc tagaactgta cgctgtacct gcatcagcat tagtaatcaa      180

cctgttaatc caaggtcttt agaaaaactt gaaattattc ctgcaagcca attttgtcca      240

cgtgttgaga tcattgctac aatgaaaaag aagggtgaga agagatgtct gaatccagaa      300

tcgaaggcca tcaagaattt actgaaagca gttagcaagg aaaggtctaa aagatctcct      360

taaaaccaga ggggagcaaa atcgatgcag tgcttccaag gatggaccac acagaggctg      420

cctctcccat cacttcccta catggagtat atgtcaagcc ataattgttc ttagtttgca      480

gttacactaa aaggtgacca atgatggtca ccaaatcagc tgctactact cctgtaggaa      540

ggttaatgtt catcatccta agctattcag taataactct accctggcac tataatgtaa      600

gctctactga ggtgctatgt tcttagtgga tgttctgacc ctgcttcaaa tatttccctc      660

acctttccca tcttccaagg gtactaagga atctttctgc tttggggttt atcagaattc      720

tcagaatctc aaataactaa aaggtatgca atcaaatctg ctttttaaag aatgctcttt      780

acttcatgga cttccactgc catcctccca aggggcccaa attctttcag tggctaccta      840

catacaattc caaacacata caggaaggta gaaatatctg aaaatgtatg tgtaagtatt      900

cttatttaat gaaagactgt acaaagtaga agtcttagat gtatatattt cctatattgt      960

tttcagtgta catggaataa catgtaatta agtactatgt atcaatgagt aacaggaaaa     1020

ttttaaaaat acagatagat atatgctctg catgttacat aagataaatg tgctgaatgg     1080

ttttcaaaat aaaaatgagg tactctcctg gaaatattaa gaaagactat ctaaatgttg     1140

aaagatcaaa aggttaataa agtaattata actaa                                1175


<210>  25
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                  15      


Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                  25                  30          


Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                  40                  45              


Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                  55                  60                  


Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                  70                  75                  80  


Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val 
                85                  90                  95      


Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly His 
            100                 105                 110         


Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn Val 
        115                 120                 125             


Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser Val 
    130                 135                 140                 


Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg Pro 
145                 150                 155                 160 


Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys 
                165                 170                 175     


Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val 
            180                 185                 190         


Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala Ala 
        195                 200                 205             


Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro His 
    210                 215                 220                 


Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu Leu 
225                 230                 235                 240 


Pro 
    


<210>  26
<211>  1772
<212>  DNA
<213>  Homo sapiens

<400>  26
agacgggaag cctggactgt gggttggggg cagcctcagc ctctccaacc tggcacccac       60

tgcccgtggc ccttaggcac ctgcttgggg tcctggagcc ccttaaggcc accagcaaat      120

cctaggagac cgagtcttgg cacgtgaaca gagccagatt tcacactgag cagctgcagt      180

cggagaaatc agagaaagcg tcacccagcc ccagattccg aggggcctgc cagggactct      240

ctcctcctgc tccttggaaa ggaagacccc gaaagacccc caagccaccg gctcagacct      300

gcttctgggc tgccatggga cttgcggcca ccgccccccg gctgtcctcc acgctgccgg      360

gcagataagg gcagctgctg cccttggggc acctgctcac tcccgcagcc cagccactcc      420

tccagggcca gcccttccct gactgagtga ccacctctgc tgccccgagg ccatgtaggc      480

cgtgcttagg cctctgtgga cacactgctg gggacggcgc ctgagctctc agggggacga      540

ggaacaccac catgccccgg ggcttcacct ggctgcgcta tcttgggatc ttccttggcg      600

tggccttggg gaatgagcct ttggagatgt ggcccttgac gcagaatgag gagtgcactg      660

tcacgggttt tctgcgggac aagctgcagt acaggagccg acttcagtac atgaaacact      720

acttccccat caactacaag atcagtgtgc cttacgaggg ggtgttcaga atcgccaacg      780

tcaccaggct gagggcccag gtgagcgagc gggagctgcg gtatctgtgg gtcttggtga      840

gcctcagtgc cactgagtcg gtgcaggacg tgctgctcga gggccaccca tcctggaagt      900

acctgcagga ggtggagacg ctgctgctga atgtccagca gggcctcacg gatgtggagg      960

tcagccccaa ggtggaatcc gtgttgtccc tcttgaatgc cccagggcca aacctgaagc     1020

tggtgcggcc caaagccctg ctggacaact gcttccgggt catggagctg ctgtactgct     1080

cctgctgtaa acaaagctcc gtcctaaact ggcaggactg tgaggtgcca agtcctcagt     1140

cttgcagccc agagccctca ttgcagtatg cggccaccca gctgtaccct ccgcccccgt     1200

ggtcccccag ctccccgcct cactccacgg gctcggtgag gccggtcagg gcacagggcg     1260

agggcctctt gccctgagca ccctggatgg tgactgcgga taggggcagc cagaccagct     1320

cccacaggag ttcaactggg tctgagactt caaggggtgg tggtgggagc cccccttggg     1380

agaggacccc tgggaagggt gtttttcctt tgagggggat tctgtgccac agcagggctc     1440

agcttcctgc cttccatagc tgtcatggcc tcacctggag cggaggggac ctggggacct     1500

gaaggtggat ggggacacag ctcctggctt ctcctggtgc tgccctcact gtccccccgc     1560

ctaaaggggg tactgagcct cctgtggccc gcagcagtga gggcacagct gtgggttgca     1620

ggggagacag ccagcacggc gtggccattc tatgaccccc cagcctggca gactggggag     1680

ctgggggcag agggcggtgc caagtgccac atcttgccat agtggatgct cttccagttt     1740

cttttttcta ttaaacaccc cacttccttt gg                                   1772


<210>  27
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Gly Cys Pro Ser Leu Met Glu Pro Pro 
625                 630                 635                 640 


Ser Pro Arg Glu Asp Met Arg Leu Leu Tyr Leu Gly Phe Gln Leu Met 
                645                 650                 655     


Leu Phe Ser Tyr Val Lys Val Asn Arg Arg Phe Cys Leu Leu Gly Val 
            660                 665                 670         


Phe Ile Lys Leu Pro Phe Leu Tyr Val Val Ala Thr Glu Ser Pro Thr 
        675                 680                 685             


Thr Leu Thr Ser Leu 
    690             


<210>  28
<211>  6901
<212>  DNA
<213>  Homo sapiens

<400>  28
attccgcggc cgccgccagc tgaggggagc gtcgcgggcc gaggagcaga tgccgcgggg       60

gccgctcgca gccgccgctg acttgtgaat gggaccggga ctggggccgg gactgacacc      120

gcagcgcttg ccctgcgcca gggactggcg gctcggaggt tgcgtccacc ctcaagggcc      180

ccagaaatca ctgtgttttc agctcagcgg ccctgtgaca ttccttcgtg ttgtcatttg      240

ttgagtgacc aatcagatgg gtggagtgtg ttacagaaat tggcagcaag tatccaatgg      300

gtgaagaaga agctaactgg ggacgtgggc agccctgacg tgatgagctc aaccagcaga      360

gacattccat cccaagagag gtctgcgtga cgcgtccggg aggccaccct cagcaagacc      420

accgtacagt tggtggaagg ggtgacagct gcattctcct gtgcctacca cgtaaccaaa      480

aatgaaggag aactactgtt tacaagccgc cctggtgtgc ctgggcatgc tgtgccacag      540

ccatgccttt gccccagagc ggcgggggca cctgcggccc tccttccatg ggcaccatga      600

gaagggcaag gaggggcagg tgctacagcg ctccaagcgt ggctgggtct ggaaccagtt      660

cttcgtgata gaggagtaca ccgggcctga ccccgtgctt gtgggcaggc ttcattcaga      720

tattgactct ggtgatggga acattaaata cattctctca ggggaaggag ctggaaccat      780

ttttgtgatt gatgacaaat cagggaacat tcatgccacc aagacgttgg atcgagaaga      840

gagagcccag tacacgttga tggctcaggc ggtggacagg gacaccaatc ggccactgga      900

gccaccgtcg gaattcattg tcaaggtcca ggacattaat gacaaccctc cggagttcct      960

gcacgagacc tatcatgcca acgtgcctga gaggtccaat gtgggaacgt cagtaatcca     1020

ggtgacagct tcagatgcag atgaccccac ttatggaaat agcgccaagt tagtgtacag     1080

tatcctcgaa ggacaaccct atttttcggt ggaagcacag acaggtatca tcagaacagc     1140

cctacccaac atggacaggg aggccaagga ggagtaccac gtggtgatcc aggccaagga     1200

catgggtgga catatgggcg gactctcagg gacaaccaaa gtgacgatca cactgaccga     1260

tgtcaatgac aacccaccaa agtttccgca gagcgtatac cagatgtctg tgtcagaagc     1320

agccgtccct ggggaggaag taggaagagt gaaagctaaa gatccagaca ttggagaaaa     1380

tggcttagtc acatacaata ttgttgatgg agatggtatg gaatcgtttg aaatcacaac     1440

ggactatgaa acacaggagg gggtgataaa gctgaaaaag cctgtagatt ttgaaaccaa     1500

aagagcctat agcttgaagg tagaggcagc caacgtgcac atcgacccga agtttatcag     1560

caatggccct ttcaaggaca ctgtgaccgt caagatctca gtagaagatg ctgatgagcc     1620

ccctatgttc ttggccccaa gttacatcca cgaagtccaa gaaaatgcag ctgctggcac     1680

cgtggttggg agagtgcatg ccaaagaccc tgatgctgcc aacagcccga taaggtattc     1740

catcgatcgt cacactgacc tcgacagatt tttcactatt aatccagagg atggttttat     1800

taaaactaca aaacctctgg atagagagga aacagcctgg ctcaacatca ctgtctttgc     1860

agcagaaatc cacaatcggc atcaggaagc caaagtccca gtggccatta gggtccttga     1920

tgtcaacgat aatgctccca agtttgctgc cccttatgaa ggtttcatct gtgagagtga     1980

tcagaccaag ccactttcca accagccaat tgttacaatt agtgcagatg acaaggatga     2040

cacggccaat ggaccaagat ttatcttcag cctaccccct gaaatcattc acaatccaaa     2100

tttcacagtc agagacaacc gagataacac agcaggcgtg tacgcccggc gtggagggtt     2160

cagtcggcag aagcaggact tgtaccttct gcccatagtg atcagcgatg gcggcatccc     2220

gcccatgagt agcaccaaca ccctcaccat caaagtctgc gggtgcgacg tgaacggggc     2280

actgctctcc tgcaacgcag aggcctacat tctgaacgcc ggcctgagca caggcgccct     2340

gatcgccatc ctcgcctgca tcgtcattct cctgggttgc ccaagcttaa tggaaccccc     2400

ctctcccagg gaagacatga gattgcttta tctgggcttc cagctgatgc tattttccta     2460

tgttaaagta aacagaagat tttgtcttct gggggtcttt ataaaacttc ctttcctcta     2520

tgtggtggct acagagagtc caaccacact tacgtcattg tagtattgtt tgtgaccctg     2580

agaaggcaaa agaaagaacc actcattgtc tttgaggaag aagatgtccg tgagaacatc     2640

attacttatg atgatgaagg gggtggggaa gaagacacag aagcctttga tattgccacc     2700

ctccagaatc ctgatggtat caatggattt atcccccgca aagacatcaa acctgagtat     2760

cagtacatgc ctagacctgg gctccggcca gcgcccaaca gcgtggatgt cgatgacttc     2820

atcaacacga gaatacagga ggcagacaat gaccccacgg ctcctcctta tgactccatt     2880

caaatctacg gttatgaagg caggggctca gtggccgggt ccctgagctc cctagagtcg     2940

gccaccacag attcagactt ggactatgat tatctacaga actggggacc tcgttttaag     3000

aaactagcag atttgtatgg ttccaaagac acttttgatg acgattctta acaataacga     3060

tacaaatttg gccttaagaa ctgtgtctgg cgttctcaag aatctagaag atgtgtaaac     3120

aggtattttt ttaaatcaag gaaaggctca tttaaaacag gcaaagtttt acagagagga     3180

tacatttaat aaaactgcga ggacatcaaa gtggtaaata ctgtgaaata ccttttctca     3240

caaaaaggca aatattgaag ttgtttatca acttcgctag aaaaaaaaaa cacttggcat     3300

acaaaatatt taagtgaagg agaagtctaa cgctgaactg acaatgaagg gaaattgttt     3360

atgtgttatg aacatccaag tctttcttct tttttaagtt gtcaaagaag cttccacaaa     3420

attagaaagg acaacagttc tgagctgtaa tttcgcctta aactctggac actctatatg     3480

tagtgcattt ttaaacttga aatatataat attcagccag cttaaaccca tacaatgtat     3540

gtacaataca atgtacaatt atgtctcttg agcatcaatc ttgttactgc tgattcttgt     3600

aaatcttttt gcttctactt tcatcttaaa ctaatacgtg ccagatataa ctgtcttgtt     3660

tcagtgagag acgccctatt tctatgtcat ttttaatgta tctatttgta caattttaaa     3720

gttcttattt tagtatacgt ataaatatca gtattctgac atgtaagaaa atgttacggc     3780

atcacactta tattttatga acattgtact gttgctttaa tatgagcttc aatataagaa     3840

gcaatctttg aaataaaaaa agattttttt ttaattctgg gtttgattct taacattgaa     3900

acaaacgtta agtatttcta atgatccatt tatatttcta atttaattgt gatcttttaa     3960

taaccctatt tatgatctgt tgttgtctgt ctgctgcttt tattgtttat ttaaaatcaa     4020

atatgtttta caaatgtttt ttcagacaag attctgtaac atcatgtaaa gcttttttgt     4080

acattcttgg tgttaacctc ctggcttctc ttcacacaca tcttctaaaa aagaaggatg     4140

tgaaagaact aggtcagtct atgactttgc aatatgtgtt atatagtatg catttatctt     4200

gtatatcagt aatttgatgg ttatgagaga tgaatccatg agggaatgga gctatcagaa     4260

ctctaatgtt ccaggtatac attctatgcc ccacactgag cactggggaa ctgggggact     4320

agagtcaaaa atataaattt gcccagactc taatgttatt ctattttttc ttctgttgaa     4380

cttaccaggc tattgtaaga ctcttgatag ttgaaactgc ttatttttcc tcctgtaatt     4440

ttaactaatt gtaaaatgat gtggcatttt atgttttaat gagaatgggc gattcattta     4500

aaaaagcttt gtttagaata tgcttggggc cgtaagctca gaatgagggc agggaccatt     4560

ttggattctg agagtcgatg ccatttggtc caggagtgtg tctacagtcc cctgcattcc     4620

agctagtttc ttggggattg aaacttatgt gaagggcatt tcacctgttc agttgggcca     4680

aaggtcaaaa cgtagcaata cttggggaaa gaccacataa agtcacactg caagtgcttt     4740

ccctctttcc ccctacacac agggcacgtg ctttttcttg gattgcagac aatttttaca     4800

gtttttttct gactttattg tgaaagtttg tttcaagcat ttcttgatat catgttatgt     4860

actattttta tgatttagtc aacatgcata caaagaaatg ttttttatga agtgctcact     4920

tccattttac tttgcattga aatcaaattg ggctgaacac ttcaatggaa tacattttgt     4980

ggacaatgtc actttagaat ctttcatctc agtgaaggat tacacattct caatacttcc     5040

ataattgcag gttgtgttca tttttttata tagtttttgt aatccaaaga atattttgct     5100

agatttgcac agatctccaa ttgaatttgc aatgaagaaa taactcaaaa ggaatatgaa     5160

tagcatttaa ataagtatac agctgtaagt aaccctgtca ccatggatga tccttttctc     5220

taggaatgta tttggattag agatgacaac tacattttcg catttttatg ttgaagtctt     5280

ttttaaaaag gctgtttact tttcagtagt taagaatact tgtttttctt tttctttttt     5340

tttttttttt ttacctttta ttttttcgtt aagcctctat tgtttgtaga acactcttag     5400

aaacttggaa ataaaatgtc tttcccaact agtggagtcc tttttcattt ggagcacatt     5460

gccttaaaag aagtcttaat ttaaacggtc cttccttatt ctaaagtaat cactgtttta     5520

taccatctat gcagctaaaa gaaggaacat gcttctgttc ttttcctcaa gtaatggtta     5580

ttgtttctag tcatcattca ttcattgatt cattcattaa ttcatcaaaa tcttatttta     5640

taaaccctgt tccacttact ggaggattca gaatgaatct tactaccttt tctgacatct     5700

tttgataatt cagccctgta ccaaagtatc caccttgttg tcttataatc acctatttac     5760

ctatttgccc tcctagaaaa tgcaagaaga tattttctct ccttccaaat tgaaggaaga     5820

acataaaaga tataacagga aggagatggt gagatataga gtgtgagcgg aaattaggcc     5880

agctgtggca attctggaca gatcttgggt ttagctaagt tatttctttt aggcctgggt     5940

ttctgggggt gacagggaag ataaaagagt agtttatttg cacctcttgg agaattgctt     6000

aaaaatatag agatcatggc tctgtatgtc aggtggaacc aggtcaggag tatttgaaac     6060

tgctcctggg tcattgtgac atatccttca catctttttg agaaacttta taagacaatg     6120

ggggtgaatg ggggctgggc agttggagtc tctgagcaga agaggggcaa aatttatttg     6180

gcaggcagtg tggaggacag attaggagca tataaaccca gaggtgtgcc ccaggagggc     6240

ttttgcaaag gtcaatatga gatagaatga gggcctgaaa taattcagta atttggagat     6300

ggagaagagg aaagacttct ctgctcttgc actgccatca gcctggtctg ggccatggtc     6360

atctctgacc cggaagactg accccacctc ttggctcacc ctctgcctcc caacctcctc     6420

ttcacaaaga agccagaggg atacttttaa cacacaaccc agatcacatg acttcgtaac     6480

ttaaacctct tcactggctt cccaaagact taaaatgaat tctgatgcct ttattttatt     6540

gctttacatg aacagggccc tgcgaacctc tccagtgtca ttccactcca tcctcctttc     6600

agtgcacgat gctccagcca cactggccat ctttcggttc ctgatacaaa aaaaaacacg     6660

ttccttttcc atggaaagca ggtcaccctt gttattttgt atcgatgaca actctttaaa     6720

cttattttgc tttttggctt tatgtatgtg tgtgggtggg tgggactgac tgccccacta     6780

gaatgtaagc tccatgaggg cagggaatct tgctttcttg tttaccattg tatactcagt     6840

tctttacaca gtgcctgaaa cataacaggt acacaataaa tatctattga atgaaagcaa     6900

a                                                                     6901


