                         SEQUENCE LISTING

<110>  Rush University Medical Center
       149 BIO LLC
       Gupta, Vineet
       Barbosa, Antonio J.
 
<120>  REAGENTS AND ASSAYS USING MODIFIED INTEGRIN DOMAINS

<130>  42960-317688 (R601-PCT)

<150>  62/827,461
<151>  2019-04-01

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  1135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A domain

<400>  1

Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
1               5                   10                  15      


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
            20                  25                  30          


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
        35                  40                  45              


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
    50                  55                  60                  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
65                  70                  75                  80  


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
                85                  90                  95      


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
            100                 105                 110         


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
        115                 120                 125             


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
    130                 135                 140                 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
145                 150                 155                 160 


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
                165                 170                 175     


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
            180                 185                 190         


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
        195                 200                 205             


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
    210                 215                 220                 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
225                 230                 235                 240 


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
                245                 250                 255     


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
            260                 265                 270         


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
        275                 280                 285             


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
    290                 295                 300                 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
305                 310                 315                 320 


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
                325                 330                 335     


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
            340                 345                 350         


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
        355                 360                 365             


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
    370                 375                 380                 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
385                 390                 395                 400 


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
                405                 410                 415     


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
            420                 425                 430         


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
        435                 440                 445             


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
    450                 455                 460                 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
465                 470                 475                 480 


Pro Arg Gly Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu 
                485                 490                 495     


Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
            500                 505                 510         


Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly 
        515                 520                 525             


Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly 
    530                 535                 540                 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu 
545                 550                 555                 560 


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp 
                565                 570                 575     


Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly His 
            580                 585                 590         


Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met 
        595                 600                 605             


Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp 
    610                 615                 620                 


Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu His 
625                 630                 635                 640 


Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser 
                645                 650                 655     


Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg 
            660                 665                 670         


Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val 
        675                 680                 685             


Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn 
    690                 695                 700                 


Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser 
705                 710                 715                 720 


Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu 
                725                 730                 735     


Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys 
            740                 745                 750         


Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe 
        755                 760                 765             


Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe 
    770                 775                 780                 


Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr 
785                 790                 795                 800 


Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser 
                805                 810                 815     


Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu 
            820                 825                 830         


Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys 
        835                 840                 845             


Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn 
    850                 855                 860                 


Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu 
865                 870                 875                 880 


Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys 
                885                 890                 895     


Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val 
            900                 905                 910         


Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser 
        915                 920                 925             


Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn Leu 
    930                 935                 940                 


Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg 
945                 950                 955                 960 


Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu 
                965                 970                 975     


Asn Leu Ser Ser Thr Cys His Thr Lys Glu Arg Leu Pro Ser His Ser 
            980                 985                 990         


Asp Phe Leu Ala Glu Leu Arg Lys  Ala Pro Val Val Asn  Cys Ser Ile 
        995                 1000                 1005             


Ala Val  Cys Gln Arg Ile Gln  Cys Asp Ile Pro Phe  Phe Gly Ile 
    1010                 1015                 1020             


Gln Glu  Glu Phe Asn Ala Thr  Leu Lys Gly Asn Leu  Ser Phe Asp 
    1025                 1030                 1035             


Trp Tyr  Ile Lys Thr Ser His  Asn His Leu Leu Ile  Val Ser Thr 
    1040                 1045                 1050             


Ala Glu  Ile Leu Phe Asn Asp  Ser Val Phe Thr Leu  Leu Pro Gly 
    1055                 1060                 1065             


Gln Gly  Ala Phe Val Arg Ser  Gln Thr Glu Thr Lys  Val Glu Pro 
    1070                 1075                 1080             


Phe Glu  Val Pro Asn Pro Leu  Pro Leu Ile Val Gly  Ser Ser Val 
    1085                 1090                 1095             


Gly Gly  Leu Leu Leu Leu Ala  Leu Ile Thr Ala Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Leu Gly  Phe Phe Lys Arg Gln  Tyr Lys Asp Met Met  Ser Glu Gly 
    1115                 1120                 1125             


Gly Pro  Pro Gly Ala Glu Gln  
    1130                 1135 


<210>  2
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b mutated

<400>  2

Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
1               5                   10                  15      


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
            20                  25                  30          


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
        35                  40                  45              


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
    50                  55                  60                  


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
65                  70                  75                  80  


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
                85                  90                  95      


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
            100                 105                 110         


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
        115                 120                 125             


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
    130                 135                 140                 


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
145                 150                 155                 160 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
                165                 170                 175     


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
            180                 185                 190         


<210>  3
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b mutated

<400>  3

Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ser Gly Ser 
1               5                   10                  15      


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
            20                  25                  30          


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
        35                  40                  45              


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
    50                  55                  60                  


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
65                  70                  75                  80  


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
                85                  90                  95      


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
            100                 105                 110         


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
        115                 120                 125             


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
    130                 135                 140                 


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
145                 150                 155                 160 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
                165                 170                 175     


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
            180                 185                 190         


<210>  4
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cd11b mutated

<400>  4

Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ser Gly Ser 
1               5                   10                  15      


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
            20                  25                  30          


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
        35                  40                  45              


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
    50                  55                  60                  


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
65                  70                  75                  80  


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
                85                  90                  95      


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
            100                 105                 110         


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
        115                 120                 125             


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
    130                 135                 140                 


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
145                 150                 155                 160 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
                165                 170                 175     


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ala Phe Ala Ile Glu 
            180                 185                 190         


<210>  5
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b mutated

<400>  5

Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ser Gly Ser 
1               5                   10                  15      


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
            20                  25                  30          


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
        35                  40                  45              


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
    50                  55                  60                  


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
65                  70                  75                  80  


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
                85                  90                  95      


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
            100                 105                 110         


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
        115                 120                 125             


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
    130                 135                 140                 


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
145                 150                 155                 160 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Trp Glu Ala 
                165                 170                 175     


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
            180                 185                 190         


<210>  6
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b mutated

<400>  6

Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ala Gly Ala 
1               5                   10                  15      


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
            20                  25                  30          


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
        35                  40                  45              


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
    50                  55                  60                  


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
65                  70                  75                  80  


Ala His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
                85                  90                  95      


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
            100                 105                 110         


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
        115                 120                 125             


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
    130                 135                 140                 


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
145                 150                 155                 160 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
                165                 170                 175     


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
            180                 185                 190         


<210>  7
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b mutated

<400>  7

Ser Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly 
1               5                   10                  15      


Ser Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr 
            20                  25                  30          


Val Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln 
        35                  40                  45              


Tyr Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn 
    50                  55                  60                  


Asn Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly 
65                  70                  75                  80  


Arg Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe 
                85                  90                  95      


Asn Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val 
            100                 105                 110         


Ile Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val 
        115                 120                 125             


Ile Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val 
    130                 135                 140                 


Gly Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile 
145                 150                 155                 160 


Ala Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu 
                165                 170                 175     


Ala Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile 
            180                 185                 190         


Glu 
    


<210>  8
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IBTR1

<400>  8

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  9
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB2

<400>  9

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val Gln Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  10
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB3

<400>  10

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  11
<211>  1822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB1-4

<400>  11

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Gly  Cys Gly Trp Lys Phe  Glu Pro Leu Leu Gly  Glu Glu Leu 
    1370                 1375                 1380             


Asp Leu  Arg Arg Val Thr Trp  Arg Leu Pro Pro Glu  Leu Ile Pro 
    1385                 1390                 1395             


Arg Leu  Ser Ala Ser Ser Gly  Arg Ser Ser Asp Ala  Glu Ala Pro 
    1400                 1405                 1410             


His Gly  Pro Pro Asp Asp Gly  Gly Ala Gly Gly Lys  Gly Gly Ser 
    1415                 1420                 1425             


Leu Pro  Arg Ser Ala Thr Pro  Gly Pro Pro Gly Glu  His Leu Val 
    1430                 1435                 1440             


Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly Ser Thr  Asn Ser Leu 
    1445                 1450                 1455             


His Arg  Met Thr Thr Thr Ser  Ala Ala Ala Tyr Gly  Thr His Leu 
    1460                 1465                 1470             


Ser Pro  His Val Pro His Arg  Val Leu Ser Thr Ser  Ser Thr Leu 
    1475                 1480                 1485             


Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser Glu His  Ser His Ser 
    1490                 1495                 1500             


Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu Thr Ser  Val Ser Ser 
    1505                 1510                 1515             


His Asp  Ser Arg Leu Thr Ala  Gly Val Pro Asp Thr  Pro Thr Arg 
    1520                 1525                 1530             


Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser Leu Arg  Val Ser Trp 
    1535                 1540                 1545             


Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln Gly Tyr  Ser Val Glu 
    1550                 1555                 1560             


Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His Arg Leu  Asn Ile Pro 
    1565                 1570                 1575             


Asn Pro  Ala Gln Thr Ser Val  Val Val Glu Asp Leu  Leu Pro Asn 
    1580                 1585                 1590             


His Ser  Tyr Val Phe Arg Val  Arg Ala Gln Ser Gln  Glu Gly Trp 
    1595                 1600                 1605             


Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile Glu Ser  Gln Val His 
    1610                 1615                 1620             


Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly Ser Ala  Phe Thr Leu 
    1625                 1630                 1635             


Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val Phe Thr  Ala Leu Ser 
    1640                 1645                 1650             


Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg Pro Arg  Arg Pro Asn 
    1655                 1660                 1665             


Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys Glu Met  Ala Gln Gly 
    1670                 1675                 1680             


Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp Gly Asp  Ser Pro Glu 
    1685                 1690                 1695             


Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu Asn Val  Pro Tyr Lys 
    1700                 1705                 1710             


Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly Phe Gly  Pro Glu Arg 
    1715                 1720                 1725             


Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp Gly Gly  Pro Phe Pro 
    1730                 1735                 1740             


Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln His Pro  Leu Gln Ser 
    1745                 1750                 1755             


Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr Ser Ala  Thr Glu Pro 
    1760                 1765                 1770             


Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala Gln His  Leu Glu Ala 
    1775                 1780                 1785             


Gly Gly  Ser Leu Thr Arg His  Val Thr Gln Glu Phe  Val Ser Arg 
    1790                 1795                 1800             


Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr His Met  Asp Gln Gln 
    1805                 1810                 1815             


Phe Phe  Gln Thr 
    1820         


<210>  12
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB1-5

<400>  12

Met Pro Arg Ala Pro Ala Pro Leu Tyr Ala Cys Leu Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Leu Pro Arg Leu Ala Gly Leu Asn Ile Cys Thr Ser Gly Ser 
            20                  25                  30          


Ala Thr Ser Cys Glu Glu Cys Leu Leu Ile His Pro Lys Cys Ala Trp 
        35                  40                  45              


Cys Ser Lys Glu Asp Phe Gly Ser Pro Arg Ser Ile Thr Ser Arg Cys 
    50                  55                  60                  


Asp Leu Arg Ala Asn Leu Val Lys Asn Gly Cys Gly Gly Glu Ile Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Phe His Val Leu Arg Ser Leu Pro Leu Ser Ser 
                85                  90                  95      


Lys Gly Ser Gly Ser Ala Gly Trp Asp Val Ile Gln Met Thr Pro Gln 
            100                 105                 110         


Glu Ile Ala Val Asn Leu Arg Pro Gly Asp Lys Thr Thr Phe Gln Leu 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Leu Ser Met Lys Asp Asp Leu Asp Asn Ile Arg Ser Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg 
                165                 170                 175     


Leu Gly Phe Gly Ser Phe Val Asp Lys Asp Ile Ser Pro Phe Ser Tyr 
            180                 185                 190         


Thr Ala Pro Arg Tyr Gln Thr Asn Pro Cys Ile Gly Tyr Lys Leu Phe 
        195                 200                 205             


Pro Asn Cys Val Pro Ser Phe Gly Phe Arg His Leu Leu Pro Leu Thr 
    210                 215                 220                 


Asp Arg Val Asp Ser Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser 
225                 230                 235                 240 


Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Val Leu Gln Ala 
                245                 250                 255     


Ala Val Cys Lys Glu Lys Ile Gly Trp Arg Lys Asp Ala Leu His Leu 
            260                 265                 270         


Leu Val Phe Thr Thr Asp Asp Val Pro His Ile Ala Leu Asp Gly Lys 
        275                 280                 285             


Leu Gly Gly Leu Val Gln Pro His Asp Gly Gln Cys His Leu Asn Glu 
    290                 295                 300                 


Ala Asn Glu Tyr Thr Ala Ser Asn Gln Met Asp Tyr Pro Ser Leu Ala 
305                 310                 315                 320 


Leu Leu Gly Glu Lys Leu Ala Glu Asn Asn Ile Asn Leu Ile Phe Ala 
                325                 330                 335     


Val Thr Lys Asn His Tyr Met Leu Tyr Lys Asn Phe Thr Ala Leu Ile 
            340                 345                 350         


Pro Gly Thr Thr Val Glu Ile Leu Asp Gly Asp Ser Lys Asn Ile Ile 
        355                 360                 365             


Gln Leu Ile Ile Asn Ala Tyr Asn Ser Ile Arg Ser Lys Val Glu Leu 
    370                 375                 380                 


Ser Val Trp Asp Gln Pro Glu Asp Leu Asn Leu Phe Phe Thr Ala Thr 
385                 390                 395                 400 


Cys Gln Asp Gly Val Ser Tyr Pro Gly Gln Arg Lys Cys Glu Gly Leu 
                405                 410                 415     


Lys Ile Gly Asp Thr Ala Ser Phe Glu Val Ser Leu Glu Ala Arg Ser 
            420                 425                 430         


Cys Pro Ser Arg His Thr Glu His Val Phe Ala Leu Arg Pro Val Gly 
        435                 440                 445             


Phe Arg Asp Ser Leu Glu Val Gly Val Thr Tyr Asn Cys Thr Cys Gly 
    450                 455                 460                 


Cys Ser Val Gly Leu Glu Pro Asn Ser Ala Arg Cys Asn Gly Ser Gly 
465                 470                 475                 480 


Thr Tyr Val Cys Gly Leu Cys Glu Cys Ser Pro Gly Tyr Leu Gly Thr 
                485                 490                 495     


Arg Cys Glu Cys Gln Asp Gly Glu Asn Gln Ser Val Tyr Gln Asn Leu 
            500                 505                 510         


Cys Arg Glu Ala Glu Gly Lys Pro Leu Cys Ser Gly Arg Gly Asp Cys 
        515                 520                 525             


Ser Cys Asn Gln Cys Ser Cys Phe Glu Ser Glu Phe Gly Lys Ile Tyr 
    530                 535                 540                 


Gly Pro Phe Cys Glu Cys Asp Asn Phe Ser Cys Ala Arg Asn Lys Gly 
545                 550                 555                 560 


Val Leu Cys Ser Gly His Gly Glu Cys His Cys Gly Glu Cys Lys Cys 
                565                 570                 575     


His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser Thr Asp Ile Ser 
            580                 585                 590         


Thr Cys Arg Gly Arg Asp Gly Gln Ile Cys Ser Glu Arg Gly His Cys 
        595                 600                 605             


Leu Cys Gly Gln Cys Gln Cys Thr Glu Pro Gly Ala Phe Gly Glu Met 
    610                 615                 620                 


Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Ser Thr Lys Arg Asp 
625                 630                 635                 640 


Cys Val Glu Cys Leu Leu Leu His Ser Gly Lys Pro Asp Asn Gln Thr 
                645                 650                 655     


Cys His Ser Leu Cys Arg Asp Glu Val Ile Thr Trp Val Asp Thr Ile 
            660                 665                 670         


Val Lys Asp Asp Gln Glu Ala Val Leu Cys Phe Tyr Lys Thr Ala Lys 
        675                 680                 685             


Asp Cys Val Met Met Phe Thr Tyr Val Glu Leu Pro Ser Gly Lys Ser 
    690                 695                 700                 


Asn Leu Thr Val Leu Arg Glu Pro Glu Cys Gly Asn Thr Pro Asn Ala 
705                 710                 715                 720 


Met Thr Ile Leu Leu Ala Val Val Gly Ser Ile Leu Leu Val Gly Leu 
                725                 730                 735     


Ala Leu Leu Ala Ile Trp Lys Leu Leu Val Thr Ile His Asp Arg Arg 
            740                 745                 750         


Glu Phe Ala Lys Phe Gln Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met 
        755                 760                 765             


Ala Ser Asn Pro Leu Tyr Arg Lys Pro Ile Ser Thr His Thr Val Asp 
    770                 775                 780                 


Phe Thr Phe Asn Lys Phe Asn Lys Ser Tyr Asn Gly Thr Val Asp 
785                 790                 795                 


<210>  13
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB1-6

<400>  13

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  14
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB1-7

<400>  14

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  15
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITB1-8

<400>  15

Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu 
1               5                   10                  15      


Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val 
            20                  25                  30          


Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala 
        35                  40                  45              


Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu 
    50                  55                  60                  


Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser 
65                  70                  75                  80  


Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val 
                85                  90                  95      


Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn 
            100                 105                 110         


Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg 
        115                 120                 125             


Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys 
    130                 135                 140                 


Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys 
                165                 170                 175     


Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val 
            180                 185                 190         


Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His 
        195                 200                 205             


Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr 
    210                 215                 220                 


Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala 
225                 230                 235                 240 


Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly 
                245                 250                 255     


Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp 
            260                 265                 270         


Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser 
        275                 280                 285             


His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp 
    290                 295                 300                 


Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met 
305                 310                 315                 320 


Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn 
                325                 330                 335     


Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys 
            340                 345                 350         


Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser 
        355                 360                 365             


Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr 
385                 390                 395                 400 


Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met 
                405                 410                 415     


Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val 
            420                 425                 430         


Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala 
        435                 440                 445             


Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His 
    450                 455                 460                 


Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys 
465                 470                 475                 480 


Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu 
                485                 490                 495     


Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys 
            500                 505                 510         


Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys 
        515                 520                 525             


Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys 
    530                 535                 540                 


Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu 
545                 550                 555                 560 


Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser 
                565                 570                 575     


Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His 
            580                 585                 590         


Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val 
        595                 600                 605             


Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys 
    610                 615                 620                 


Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys 
625                 630                 635                 640 


Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln 
                645                 650                 655     


Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln 
            660                 665                 670         


Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile 
        675                 680                 685             


Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile 
    690                 695                 700                 


Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser 
                725                 730                 735     


Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile 
            740                 745                 750         


Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn 
        755                 760                 765             


Phe 
    


<210>  16
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain CD11bA WT (WT residues 132-321)

<400>  16

Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Phe 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  17
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutation CD11bA - D140A

<400>  17

Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Phe 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  18
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutations CD11bA - D140A/F275S

<400>  18

Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Ser 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  19
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutations (underlined) CD11bA 
       - D140A/F275S/F302G

<400>  19

Asp Ser Asp Ile Ala Phe Leu Ile Ala Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Ser 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Gly Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  20
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutation (underlined) CD11bA -
       D242A

<400>  20

Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Ala Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Phe 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  21
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutation (underlined) CD11bA -
       F275S

<400>  21

Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Ser 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  22
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutations (underlined) CD11bA 
       - F275S/F302G

<400>  22

Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Ser 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Gly Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  23
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11b A-domain with designed point mutations (underlined) CD11bA 
       - D242A/F275S/F302G

<400>  23

Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser Ile Ile Pro 
1               5                   10                  15      


His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln 
            20                  25                  30          


Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu 
        35                  40                  45              


Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro 
    50                  55                  60                  


Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr 
65                  70                  75                  80  


Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn 
                85                  90                  95      


Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Ala Gly 
            100                 105                 110         


Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala 
        115                 120                 125             


Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Ser 
    130                 135                 140                 


Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro 
145                 150                 155                 160 


Pro Arg Asp His Val Phe Gln Val Asn Asn Gly Glu Ala Leu Lys Thr 
                165                 170                 175     


Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190 


<210>  24
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain CD11aA WT, WT residues 128-321

<400>  24

Gly Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  25
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain with designed point mutation (underlined) CD11aA -
       D137A

<400>  25

Gly Asn Val Asp Leu Val Phe Leu Phe Ala Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  26
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain with designed point mutation (underlined) CD11aA -
       D238A

<400>  26

Gly Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Ala 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  27
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain with designed point mutation (underlined) CD11aA -
       F264S

<400>  27

Gly Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Ser Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  28
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain with designed point mutations (underlined) CD11aA 
       - F264S/F291G

<400>  28

Gly Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Ser Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Gly Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  29
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain with designed point mutations (underlined) CD11aA 
       - D137A/F264S/F291G

<400>  29

Gly Asn Val Asp Leu Val Phe Leu Phe Ala Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Ser Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Gly Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  30
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11a A-domain with designed point mutations (underlined) CD11aA 
       - D238A/F264S/F291G

<400>  30

Gly Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln 
1               5                   10                  15      


Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys 
            20                  25                  30          


Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr 
        35                  40                  45              


Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp 
    50                  55                  60                  


Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn 
65                  70                  75                  80  


Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu 
                85                  90                  95      


Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Ala 
            100                 105                 110         


Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile 
        115                 120                 125             


Arg Tyr Ile Ile Gly Ile Gly Lys His Ser Gln Thr Lys Glu Ser Gln 
    130                 135                 140                 


Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys 
145                 150                 155                 160 


Ile Leu Asp Thr Gly Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln 
                165                 170                 175     


Lys Lys Ile Tyr Val Ile Glu Gly 
            180                 


<210>  31
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain WT 129-319

<400>  31

Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  32
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain with designed point mutation (underlined) CD11cA -
       D138A

<400>  32

Gln Glu Gln Asp Ile Val Phe Leu Ile Ala Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  33
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain with designed point mutation (underlined) CD11cA -
       D240A

<400>  33

Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Ala 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  34
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain with designed point mutation (underlined) CD11cA -
       F275S

<400>  34

Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Ser Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  35
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain with designed point mutations (underlined) CD11cA 
       - F275S/F302G

<400>  35

Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Ser Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Gly Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  36
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain with designed point mutations (underlined) CD11cA 
       - D240A/F275S/F302G

<400>  36

Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Ala 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Ser Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Gly Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  37
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11c A-domain with designed point mutations (underlined) CD11cA 
       - D138A/F275S/F302G

<400>  37

Gln Glu Gln Asp Ile Val Phe Leu Ile Ala Gly Ser Gly Ser Ile Ser 
1               5                   10                  15      


Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala Val Ile Ser 
            20                  25                  30          


Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln Phe Ser Asn 
        35                  40                  45              


Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg Ser Ser Asn 
    50                  55                  60                  


Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly Phe Thr Tyr 
65                  70                  75                  80  


Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe His Ala Ser 
                85                  90                  95      


Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val Ile Pro Met 
        115                 120                 125             


Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly Leu Ala 
    130                 135                 140                 


Ser Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile Ala Ser Lys 
145                 150                 155                 160 


Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Gly Asp Ala Leu Lys 
                165                 170                 175     


Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile Glu Gly 
            180                 185                 190     


<210>  38
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11d A-domain WT: residues 147-337

<400>  38

Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Asp 
1               5                   10                  15      


Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly 
            20                  25                  30          


Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn 
        35                  40                  45              


Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser 
    50                  55                  60                  


Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe 
65                  70                  75                  80  


Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys 
                85                  90                  95      


Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln 
        115                 120                 125             


Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala 
    130                 135                 140                 


Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala 
145                 150                 155                 160 


Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala Leu Gly 
                165                 170                 175     


Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly 
            180                 185                 190     


<210>  39
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11d A-domain with designed point mutation (underlined) CD11dA -
       D156A

<400>  39

Gln Glu Met Asp Ile Val Phe Leu Ile Ala Gly Ser Gly Ser Ile Asp 
1               5                   10                  15      


Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly 
            20                  25                  30          


Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn 
        35                  40                  45              


Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser 
    50                  55                  60                  


Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe 
65                  70                  75                  80  


Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys 
                85                  90                  95      


Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln 
        115                 120                 125             


Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala 
    130                 135                 140                 


Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala 
145                 150                 155                 160 


Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala Leu Gly 
                165                 170                 175     


Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly 
            180                 185                 190     


<210>  40
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11d A-domain with designed point mutations (underlined) CD11dA 
       - F291S/F318G

<400>  40

Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Asp 
1               5                   10                  15      


Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly 
            20                  25                  30          


Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn 
        35                  40                  45              


Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser 
    50                  55                  60                  


Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe 
65                  70                  75                  80  


Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys 
                85                  90                  95      


Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln 
        115                 120                 125             


Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala 
    130                 135                 140                 


Ser Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala 
145                 150                 155                 160 


Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Gly Ala Ala Leu Gly 
                165                 170                 175     


Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly 
            180                 185                 190     


<210>  41
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11d A-domain with designed point mutation (underlined) CD11dA -
       D258A

<400>  41

Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Asp 
1               5                   10                  15      


Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly 
            20                  25                  30          


Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn 
        35                  40                  45              


Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser 
    50                  55                  60                  


Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe 
65                  70                  75                  80  


Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys 
                85                  90                  95      


Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Ala 
            100                 105                 110         


Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln 
        115                 120                 125             


Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala 
    130                 135                 140                 


Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala 
145                 150                 155                 160 


Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala Leu Gly 
                165                 170                 175     


Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly 
            180                 185                 190     


<210>  42
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11d A-domain with designed point mutations (underlined) CD11dA 
       - D258A/F291S/F318G

<400>  42

Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Asp 
1               5                   10                  15      


Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly 
            20                  25                  30          


Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn 
        35                  40                  45              


Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser 
    50                  55                  60                  


Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe 
65                  70                  75                  80  


Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys 
                85                  90                  95      


Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Ala 
            100                 105                 110         


Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln 
        115                 120                 125             


Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala 
    130                 135                 140                 


Ser Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala 
145                 150                 155                 160 


Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Gly Ala Ala Leu Gly 
                165                 170                 175     


Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly 
            180                 185                 190     


<210>  43
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD11d A-domain with designed point mutations (underlined) CD11dA 
       - D156A/F291S/F318G

<400>  43

Gln Glu Met Asp Ile Val Phe Leu Ile Ala Gly Ser Gly Ser Ile Asp 
1               5                   10                  15      


Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly 
            20                  25                  30          


Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn 
        35                  40                  45              


Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser 
    50                  55                  60                  


Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe 
65                  70                  75                  80  


Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys 
                85                  90                  95      


Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Asp 
            100                 105                 110         


Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln 
        115                 120                 125             


Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala 
    130                 135                 140                 


Ser Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala 
145                 150                 155                 160 


Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Gly Ala Ala Leu Gly 
                165                 170                 175     


Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly 
            180                 185                 190     


<210>  44
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Integrin beta7 (ITGB7) betaI-domain with designed point mutation 
       (underlined) and deletions: Beta7-C272S-delSDL1-delSDL2

<400>  44

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val Pro Ser Lys 
    50                  55                  60                  


Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln Ser Pro Phe 
65                  70                  75                  80  


Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln Ala Phe Glu 
                85                  90                  95      


Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp Ser Pro Glu 
            100                 105                 110         


Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln Glu Gln Ile 
        115                 120                 125             


Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser Asp Asp Thr 
    130                 135                 140                 


Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe Met Pro Ser 
145                 150                 155                 160 


Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser Arg Ser Thr 
                165                 170                 175     


Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala Leu Ser Ala 
            180                 185                 190         


Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro Val 
        195                 200                 205             


Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu Leu 
    210                 215                 220                 


Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr Asn 
225                 230                 235                 240 


Ser Leu Ser Ser Thr Val 
                245     


<210>  45
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residue C272 is replaced with Serine (to remove one Cysteine 
       site) and SDL1 (K200-F228) and SDL2 (A296-P329) residues are 
       deleted from the WT sequence

<400>  45

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  46
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1-D159A

<400>  46

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Ala Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  47
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1- V171A

<400>  47

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Ala Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  48
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1- L381A

<400>  48

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Val Gln Ala Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  49
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1- D159A/V171A

<400>  49

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Ala Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Ala Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  50
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1- D159A/L381A

<400>  50

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Ala Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Val Gln Ala Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  51
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1- V379A

<400>  51

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Ala Gln Leu Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  52
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta7Protein1 with additional designed point mutation 
       (underlined): beta7Protein1- D159A/V379A

<400>  52

Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Ala Leu Ser Tyr Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
            20                  25                  30          


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
    50                  55                  60                  


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Ser Gln 
                85                  90                  95      


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
            100                 105                 110         


Asp Asp Thr Phe His Thr Ser Val Gly Gln Val Ala Gln Ala Leu Ser 
        115                 120                 125             


Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro 
    130                 135                 140                 


Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu 
145                 150                 155                 160 


Leu Ser Glu Asp Ser Ser Asn Val Ala Gln Leu Ile Met Asp Ala Tyr 
                165                 170                 175     


Asn Ser Leu Ser Ser Thr Val 
            180             


<210>  53
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Integrin beta4 (ITGB4) betaI-domain with designed point mutation 
       (underlined) and deletions: Beta4-C244S-delSDL1-delSDL2

<400>  53

Leu Glu Ser Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser 
1               5                   10                  15      


Met Ser Asp Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala 
            20                  25                  30          


Arg Val Leu Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys 
        35                  40                  45              


Phe Val Asp Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys 
    50                  55                  60                  


Leu Lys Glu Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn 
65                  70                  75                  80  


Val Ile Ser Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln 
                85                  90                  95      


Gly Glu Arg Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp 
            100                 105                 110         


Ala Ile Leu Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro 
        115                 120                 125             


Asp Ser Thr His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr 
    130                 135                 140                 


Glu Ala Asp Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp 
145                 150                 155                 160 


Glu Arg Cys His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr 
                165                 170                 175     


Gln Asp Tyr Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His 
            180                 185                 190         


Asn Ile Ile Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr 
        195                 200                 205             


Glu Lys Leu His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln 
    210                 215                 220                 


Glu Asp Ser Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Asn Leu 
                245 


<210>  54
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residue C244 is replaced with Serine (to remove one Cysteine 
       site) and SDL1 (K177-F201) and SDL2 (E269-P305) residues are 
       deleted from the WT sequence

<400>  54

Leu Glu Ser Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser 
1               5                   10                  15      


Met Ser Asp Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala 
            20                  25                  30          


Arg Val Leu Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys 
        35                  40                  45              


Phe Val Asp Ser Phe Lys Asn Val Ile Ser Leu Thr Glu Asp Val Asp 
    50                  55                  60                  


Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg Ile Ser Gly Asn Leu Asp 
65                  70                  75                  80  


Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Thr Ala Val Ser Thr 
                85                  90                  95      


Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr His Leu Leu Val Phe Ser 
            100                 105                 110         


Thr Glu Ser Ala Phe His Tyr Ser Val Pro Thr Leu Val Arg Leu Leu 
        115                 120                 125             


Ala Lys His Asn Ile Ile Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr 
    130                 135                 140                 


Ser Tyr Tyr Glu Lys Leu His Thr Tyr Phe Pro Val Ser Ser Leu Gly 
145                 150                 155                 160 


Val Leu Gln Glu Asp Ser Ser Asn Ile Val Glu Leu Leu Glu Glu Ala 
                165                 170                 175     


Phe Asn Arg Ile Arg Ser Asn Leu 
            180                 


<210>  55
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Integrin beta5 (ITGB5) betaI-domain with designed point mutation 
       (bolded) and deletions: Beta5-C257S-delSDL1-delSDL2 
       (beta5Protein1)

<400>  55

Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Leu Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Asp Asn Ile Arg Ser Leu Gly Thr Lys Leu Ala 
            20                  25                  30          


Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Lys Asp Ile Ser Pro Phe Ser Tyr Thr Ala Pro Arg Tyr 
    50                  55                  60                  


Gln Thr Asn Pro Cys Ile Gly Tyr Lys Leu Phe Pro Asn Cys Val Pro 
65                  70                  75                  80  


Ser Phe Gly Phe Arg His Leu Leu Pro Leu Thr Asp Arg Val Asp Ser 
                85                  90                  95      


Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser Arg Arg Asp Ala Pro 
            100                 105                 110         


Glu Gly Gly Phe Asp Ala Val Leu Gln Ala Ala Val Cys Lys Glu Lys 
        115                 120                 125             


Ile Gly Trp Arg Lys Asp Ala Leu His Leu Leu Val Phe Thr Thr Asp 
    130                 135                 140                 


Asp Val Pro His Ile Ala Leu Asp Gly Lys Leu Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro His Asp Gly Gln Cys His Leu Asn Glu Ala Asn Glu Tyr Thr Ala 
                165                 170                 175     


Ser Asn Gln Met Asp Tyr Pro Ser Leu Ala Leu Leu Gly Glu Lys Leu 
            180                 185                 190         


Ala Glu Asn Asn Ile Asn Leu Ile Phe Ala Val Thr Lys Asn His Tyr 
        195                 200                 205             


Met Leu Tyr Lys Asn Phe Thr Ala Leu Ile Pro Gly Thr Thr Val Glu 
    210                 215                 220                 


Ile Leu Asp Gly Asp Ser Lys Asn Ile Ile Gln Leu Ile Ile Asn Ala 
225                 230                 235                 240 


Tyr Asn Ser Ile Arg Ser Lys Val 
                245             


<210>  56
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residue C257 is replaced with Serine (to remove one Cysteine 
       site) and SDL1 (K184-F214) and SDL2 (A282-P315) residues are 
       deleted from the WT sequence

<400>  56

Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Leu Ser 
1               5                   10                  15      


Met Lys Asp Asp Leu Asp Asn Ile Arg Ser Leu Gly Thr Lys Leu Ala 
            20                  25                  30          


Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
        35                  40                  45              


Phe Val Asp Gly Phe Arg His Leu Leu Pro Leu Thr Asp Arg Val Asp 
    50                  55                  60                  


Ser Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser Arg Arg Asp Ala 
65                  70                  75                  80  


Pro Glu Gly Gly Phe Asp Ala Val Leu Gln Ala Ala Val Ser Lys Glu 
                85                  90                  95      


Lys Ile Gly Trp Arg Lys Asp Ala Leu His Leu Leu Val Phe Thr Thr 
            100                 105                 110         


Asp Asp Val Pro His Ile Ser Leu Ala Leu Leu Gly Glu Lys Leu Ala 
        115                 120                 125             


Glu Asn Asn Ile Asn Leu Ile Phe Ala Val Thr Lys Asn His Tyr Met 
    130                 135                 140                 


Leu Tyr Lys Asn Phe Thr Ala Leu Ile Pro Gly Thr Thr Val Glu Ile 
145                 150                 155                 160 


Leu Asp Gly Asp Ser Lys Asn Ile Ile Gln Leu Ile Ile Asn Ala Tyr 
                165                 170                 175     


Asn Ser Ile Arg Ser Lys Val 
            180             


<210>  57
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Integrin beta6 (ITGB6) betaI-domain with designed point mutation 
       (underlined) and deletions: Beta6-C247S-delSDL1-SDL2

<400>  57

Thr Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala 
1               5                   10                  15      


Ser Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu 
            20                  25                  30          


Ser Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly 
        35                  40                  45              


Ser Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu 
    50                  55                  60                  


Glu Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr 
65                  70                  75                  80  


Phe Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe 
                85                  90                  95      


Asn Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro 
            100                 105                 110         


Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys 
        115                 120                 125             


Ile Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp 
    130                 135                 140                 


Ala Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile 
145                 150                 155                 160 


Pro Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met 
                165                 170                 175     


Ser Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu 
            180                 185                 190         


Val Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val 
        195                 200                 205             


His Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly 
    210                 215                 220                 


Leu Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala 
225                 230                 235                 240 


Tyr Glu Glu Leu Arg Ser Glu Val 
                245             


<210>  58
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residue C247 is replaced with Serine (to remove one Cysteine 
       site) and SDL1 (K174-F202) and SDL2 (G272-P305) residues are 
       deleted from the WT sequence

<400>  58

Thr Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala 
1               5                   10                  15      


Ser Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu 
            20                  25                  30          


Ser Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly 
        35                  40                  45              


Ser Phe Val Glu Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala 
    50                  55                  60                  


Glu Arg Phe Asn Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile 
65                  70                  75                  80  


Asp Thr Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Ser 
                85                  90                  95      


Lys Glu Lys Ile Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe 
            100                 105                 110         


Val Ser Asp Ala Asp Ser His Phe Thr Ile Gly Gln Leu Ile Asp Lys 
        115                 120                 125             


Leu Val Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln 
    130                 135                 140                 


Val His Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val 
145                 150                 155                 160 


Gly Leu Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser 
                165                 170                 175     


Ala Tyr Glu Glu Leu Arg Ser Glu Val 
            180                 185 


<210>  59
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Integrin beta8 (ITGB8) betaI-domain with designed point mutation 
       (underlined) and deletions: Beta8-C265S-delSDL1-SDL2

<400>  59

Leu Lys Lys Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala 
1               5                   10                  15      


Ser Met His Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu 
            20                  25                  30          


Ser Arg Lys Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly 
        35                  40                  45              


Ser Tyr Val Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu 
    50                  55                  60                  


Arg Ile His Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro 
65                  70                  75                  80  


His Gly Tyr Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe 
                85                  90                  95      


Glu Lys Ala Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro 
            100                 105                 110         


Glu Gly Gly Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His 
        115                 120                 125             


Ile Gly Trp Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp 
    130                 135                 140                 


Gln Thr Ser His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val 
145                 150                 155                 160 


Pro Asn Asp Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser 
                165                 170                 175     


Thr Thr Met Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile 
            180                 185                 190         


Asp Asn Asn Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His 
        195                 200                 205             


Trp Tyr Lys Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu 
    210                 215                 220                 


Ile Glu Ser Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr 
225                 230                 235                 240 


Gln Lys Leu Ile Ser Glu Val 
                245         


<210>  60
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  residue C265 is replaced with Serine (to remove one Cysteine 
       site) and SDL1 (K193-H221) and SDL2 (A290-P322) residues are 
       deleted from the WT sequence

<400>  60

Leu Lys Lys Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala 
1               5                   10                  15      


Ser Met His Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu 
            20                  25                  30          


Ser Arg Lys Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly 
        35                  40                  45              


Ser Tyr Val Asp Gly Tyr Ile His Val Leu Ser Leu Thr Glu Asn Ile 
    50                  55                  60                  


Thr Glu Phe Glu Lys Ala Val His Arg Gln Lys Ile Ser Gly Asn Ile 
65                  70                  75                  80  


Asp Thr Pro Glu Gly Gly Phe Asp Ala Met Leu Gln Ala Ala Val Ser 
                85                  90                  95      


Glu Ser His Ile Gly Trp Arg Lys Glu Ala Lys Arg Leu Leu Leu Val 
            100                 105                 110         


Met Thr Asp Gln Thr Ser His Leu Ser Leu Gly Gln Leu Ser Glu Lys 
        115                 120                 125             


Leu Ile Asp Asn Asn Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln 
    130                 135                 140                 


Phe His Trp Tyr Lys Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala 
145                 150                 155                 160 


Gly Glu Ile Glu Ser Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu 
                165                 170                 175     


Ala Tyr Gln Lys Leu Ile Ser Glu Val 
            180                 185 


<210>  61
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 2

<400>  61
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatct ggtattcggc      300

ggagggacca agctgaccgt cctaggtgag ggtaaatctt ccggatctgg ttccgaatcc      360

aaagctagcc aggttcagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca      420

gtgaaggtct cctgcaaggc ttctggatac accttcaccg gctactatat gcactgggtg      480

cgacaggccc ctggacaagg gcttgagtgg atgggatgga tcaaccctaa cagtggtggc      540

acaaactatg cacagaagtt tcagggctgg gtcaccatga ccagggacac gtccatcagc      600

acagcctaca tggagctgag caggctgaga tctgacgaca cggccgtgta ttactgtgcg      660

cgctacatgg ttcggggagg agggattgac tactggggcc agggcaccct ggtcaccgtc      720

tcctca                                                                 726


<210>  62
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 3


<220>
<221>  misc_feature
<222>  (696)..(696)
<223>  n is a, c, g, or t

<400>  62
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccacctcagg aaatacagct tccttgacca tcactggggc tcaggcggag      240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatct ggtattcggc      300

ggagggacca agctcaccgt cctaggtgag ggtaaatctt ccggatctgg ttccgaatcc      360

aaagctagcc aggtgcagct gcaggagtcg ggcccaggac tggtgaaccc ttcacagacc      420

ctgtccctca cctgcactgt ctctggtggc tccatcagca gtggtggtta ctactggagc      480

tggatccgcc agcacccagg gaagggcctg gagtggattg ggtacatctc ttacagtggg      540

agcacctact acaacccctc cctcaagagt cgagttacca tatcagtaga cacatctaag      600

aaccagttct ccctgaagct gagctctgtg actgccgcgg acacggccgt gtattactgt      660

gcgagaggtc ggacttggtt cgacccctgg ggccanggca ccctggtcac cgtctcctca      720


<210>  63
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 5

<400>  63
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccacctcggg aaattttgct tccttgacca tcacgggggc tcaggcggaa      240

gatggggctg actattactg tcactcccgg gacagcagtg gcaaccatct ggttttcggc      300

ggggggacca agctcaccgt cctaggtgag ggtaaatctt ccggatctgg ttccgaatcc      360

aaagctagcg aggtgcagct ggtgcagtct ggggcagagg tgaaaaagcc gggggagtct      420

ctgaagatct cctgtaaggg ttctggatac agctttacca gctactggat cggctgggtg      480

cgccagatgc ccgggaaagg cctggagtgg atggggatca tctatcctgg tgactctgat      540

accagataca gcccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccatcagc      600

accgcctacc tgcagtggag cagcctgaag gcctcggaca ccgccatgta ttactgtgcg      660

agacgtgcta ggggtgcttt tgatatctgg ggccaaggaa ccctggtcac cgtctcctca      720


<210>  64
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 6

<400>  64
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctctttat      300

gtcttcggag ctgggaccaa gctgaccgtc ctaggtgagg gtaaatcttc cggatctggt      360

tccgaatcca aagctagcca ggtgcagctg caggagtcgg gcccaggact ggtgaagcct      420

tcggagaccc tgtccctcac gtgcagtgtc tctggtggct ccaccagtag ttactactgg      480

agctggatcc ggcagccccc agggaagggg ctggagtgga ttgggtatat ctcgaacagt      540

gggagcacca actacaaccc ctccctcaag agtcgagtca ccatgtcaat agacacgtcc      600

aacaaccagt tctccctgaa gttgagttct gtgaccgccg cagacacggc cgtctattac      660

tgtgcgagcc acttgggagc tacctggcgg tggggccagg gaaccctggt caccgtctcc      720

tca                                                                    723


<210>  65
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 11

<400>  65
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag ccactggatt caccttcagt aactatggca tacactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt acatcatatg atggaagtaa taaatattat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agttgaggac acggctgtgt attactgtgc caaagatcgt      300

ggttactaca catacgtatt tgactattgg ggccggggaa ccctggtcac cgtctcctca      360

ggcgagggta aatcttccgg atctggttcc gaatccaaag ctagcgatgt tgtgatgacc      420

cagactccac tctccctgcc cgtcacccct ggagagccgg ccgccatctc ctgcaggtct      480

agtcagagcc tcctgcatag taatggatac aactatttgg attggtacct gcagaagcca      540

gggcagtctc cacagctcct gatctatttg ggttctaatc gggcctccgg ggtccctgac      600

aggttcagtg gcagtggatc aggcacagat tttacactga aaatcagcag agtggaggct      660

gaggatgttg gggtttatta ctgcatgcaa gctgtacaaa ctgtcgac                   708


<210>  66
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 13

<400>  66
gaagtgcagc tgctggaaag cggcggtggt ctggttcagc cgggtggcag cctgcgtctg       60

agctgtgcgg cgagcggctt tacctttagc agcgatttaa tgagctgggt gcgtcaggca      120

ccgggcaaag gcctggaatg ggtgagcgcg attagcggca gcggcggcag cacctattat      180

gcggatagcg tgaaaggccg ttttaccatt agccgtgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg tgcggaagat accgcggtgt attattgcgc gaaaaatgag      300

gttatctttg attattgggg ccagggcacc ctggttaccg ttagcagcgc gagcaccaaa      360

ggcctgagca tgtttgatta ttggggccag ggcaccaaag tggaaattaa a               411


<210>  67
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 14

<400>  67
gatgttgtga tgacccagtc tccactctcc ctgcccgcca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacactgatg gaaacaccta cttgaattgg      120

tttcagcaga ggcccggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctcatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgca tgcaaggtac acactggcct      300

ccgacgttcg gccaagggac caaggtggaa atcaaagagg gtaaatcttc cggatctggt      360

tccgaatcca aagctagcga ggtgcagctg gtgcagtctg gggctgaggt gaagaagcct      420

ggggcctcag tgaaggtctc ctgcaaggct tctggaggca ccttcagcag ctatgctatc      480

agctgggtgc gacaggcccc tggacaaggg cttgagtgga tgggagggat catccctatc      540

tttggtacag caaactacgc acagaagttc cagggcagag tcacgattac cgcggacgaa      600

tccacgagca cagcctacat ggagctgagc agcctgagat ctgaggacac ggccgtgtat      660

tactgtgcga gtagcggggt tgactactgg ggccagggca ccctggtcac cgtctcctca      720


<210>  68
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 8

<400>  68
gatgtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtacag cctctggatt caccttcagt aactatgcca tgaactgggt ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcagtt atttcaagta gtggtagtcg ccgaaactat      180

gcagactccg tgaaaggccg attcaccatc tccagagaca acgccaagag cacgctgtat      240

ctgcaaatga acagcctgaa acctgaggat acggccgtat attactgtgc aaaggttcga      300

gatgcaggct actacagatg gaacctgaat gaccttgatt accggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  69
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15      


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240 


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285             


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415     


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445             


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460                 


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480 


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495     


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510         


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525             


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540                 


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560 


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575     


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590         


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605             


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620                 


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640 


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655     


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670         


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685             


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700                 


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720 


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735     


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750         


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765             


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780                 


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800 


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815     


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830         


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845             


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860                 


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880 


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895     


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910         


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925             


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940                 


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960 


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975     


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990         


Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn 
        995                 1000                 1005             


Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser 
    1010                 1015                 1020             


Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro 
    1025                 1030                 1035             


Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn 
    1100                 1105                 1110             


Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210>  70
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  71
<211>  1051
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  72
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  73
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  74
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Leu Leu Phe Leu Thr Ser Val Ser Tyr Thr Asp Pro Asp 
            260                 265                 270         


Gln Phe Val Tyr Lys Thr Arg Pro Pro Arg Glu Gln Pro Asp Thr Phe 
        275                 280                 285             


Pro Asp Val Met Met Asn Ser Tyr Leu Gly Phe Ser Leu Asp Ser Gly 
    290                 295                 300                 


Lys Gly Ile Val Ser Lys Asp Glu Ile Thr Phe Val Ser Gly Ala Pro 
305                 310                 315                 320 


Arg Ala Asn His Ser Gly Ala Val Val Leu Leu Lys Arg Asp Met Lys 
                325                 330                 335     


Ser Ala His Leu Leu Pro Glu His Ile Phe Asp Gly Glu Gly Leu Ala 
            340                 345                 350         


Ser Ser Phe Gly Tyr Asp Val Ala Val Val Asp Leu Asn Lys Asp Gly 
        355                 360                 365             


Trp Gln Asp Ile Val Ile Gly Ala Pro Gln Tyr Phe Asp Arg Asp Gly 
    370                 375                 380                 


Glu Val Gly Gly Ala Val Tyr Val Tyr Met Asn Gln Gln Gly Arg Trp 
385                 390                 395                 400 


Asn Asn Val Lys Pro Ile Arg Leu Asn Gly Thr Lys Asp Ser Met Phe 
                405                 410                 415     


Gly Ile Ala Val Lys Asn Ile Gly Asp Ile Asn Gln Asp Gly Tyr Pro 
            420                 425                 430         


Asp Ile Ala Val Gly Ala Pro Tyr Asp Asp Leu Gly Lys Val Phe Ile 
        435                 440                 445             


Tyr His Gly Ser Ala Asn Gly Ile Asn Thr Lys Pro Thr Gln Val Leu 
    450                 455                 460                 


Lys Gly Ile Ser Pro Tyr Phe Gly Tyr Ser Ile Ala Gly Asn Met Asp 
465                 470                 475                 480 


Leu Asp Arg Asn Ser Tyr Pro Asp Val Ala Val Gly Ser Leu Ser Asp 
                485                 490                 495     


Ser Val Thr Ile Phe Arg Ser Arg Pro Val Ile Asn Ile Gln Lys Thr 
            500                 505                 510         


Ile Thr Val Thr Pro Asn Arg Ile Asp Leu Arg Gln Lys Thr Ala Cys 
        515                 520                 525             


Gly Ala Pro Ser Gly Ile Cys Leu Gln Val Lys Ser Cys Phe Glu Tyr 
    530                 535                 540                 


Thr Ala Asn Pro Ala Gly Tyr Asn Pro Ser Ile Ser Ile Val Gly Thr 
545                 550                 555                 560 


Leu Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser Ser Arg Val 
                565                 570                 575     


Gln Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln Glu Leu Thr 
            580                 585                 590         


Leu Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr Leu Trp Leu 
        595                 600                 605             


Gln Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile Thr Ala Ser 
    610                 615                 620                 


Val Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn Ser Leu Pro 
625                 630                 635                 640 


Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr Ala His Ile 
                645                 650                 655     


Asp Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn Val Cys Asn 
            660                 665                 670         


Ser Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu Gly Asn Gln 
        675                 680                 685             


Asp Lys Phe Ser Tyr Leu Pro Ile Gln Lys Gly Val Pro Glu Leu Val 
    690                 695                 700                 


Leu Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val Thr Asn Ser 
705                 710                 715                 720 


Pro Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp Ala His Glu 
                725                 730                 735     


Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser Ala Tyr 
            740                 745                 750         


Arg Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys Val Ala Asn 
        755                 760                 765             


Gln Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro Phe Lys Arg 
    770                 775                 780                 


Asn Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr Glu Val Thr 
785                 790                 795                 800 


Phe Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu Thr Thr Ser 
                805                 810                 815     


Asn Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys Val Val Ile 
            820                 825                 830         


Glu Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser Gln Val Tyr 
        835                 840                 845             


Phe Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser Glu Asp Glu 
    850                 855                 860                 


Val Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn Leu Gly Lys 
865                 870                 875                 880 


Pro Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln Trp Pro Lys 
                885                 890                 895     


Glu Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys Val Glu Ser 
            900                 905                 910         


Lys Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu Ile Asn Ser 
        915                 920                 925             


Leu Asn Leu Thr Glu Ser His Asn Ser Arg Lys Lys Arg Glu Ile Thr 
    930                 935                 940                 


Glu Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe Ala Glu Arg 
945                 950                 955                 960 


Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys Val Asn Ile 
                965                 970                 975     


Arg Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu Ile Leu Arg 
            980                 985                 990         


Ser Arg Leu Trp Asn Ser Thr Phe  Leu Glu Glu Tyr Ser  Lys Leu Asn 
        995                 1000                 1005             


Tyr Leu  Asp Ile Leu Met Arg  Ala Phe Ile Asp Val  Thr Ala Ala 
    1010                 1015                 1020             


Ala Glu  Asn Ile Arg Leu Pro  Asn Ala Gly Thr Gln  Val Arg Val 
    1025                 1030                 1035             


Thr Val  Phe Pro Ser Lys Thr  Val Ala Gln Tyr Ser  Gly Val Pro 
    1040                 1045                 1050             


Trp Trp  Ile Ile Leu Val Ala  Ile Leu Ala Gly Ile  Leu Met Leu 
    1055                 1060                 1065             


Ala Leu  Leu Val Phe Ile Leu  Trp Lys Cys Gly Phe  Phe Lys Arg 
    1070                 1075                 1080             


Ser Arg  Tyr Asp Asp Ser Val  Pro Arg Tyr His Ala  Val Arg Ile 
    1085                 1090                 1095             


Arg Lys  Glu Glu Arg Glu Ile  Lys Asp Glu Lys Tyr  Ile Asp Asn 
    1100                 1105                 1110             


Leu Glu  Lys Lys Gln Trp Ile  Thr Lys Trp Asn Glu  Asn Glu Ser 
    1115                 1120                 1125             


Tyr Ser  
    1130 


<210>  75
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile Cys 
1               5                   10                  15      


Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg Ala Val 
            20                  25                  30          


Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Phe Ser Val Ala Leu His Arg Gln Leu Gln Pro 
    50                  55                  60                  


Arg Pro Gln Ser Trp Leu Leu Val Gly Ala Pro Gln Ala Leu Ala Leu 
65                  70                  75                  80  


Pro Gly Gln Gln Ala Asn Arg Thr Gly Gly Leu Phe Ala Cys Pro Leu 
                85                  90                  95      


Ser Leu Glu Glu Thr Asp Cys Tyr Arg Val Asp Ile Asp Gln Gly Ala 
            100                 105                 110         


Asp Met Gln Lys Glu Ser Lys Glu Asn Gln Trp Leu Gly Val Ser Val 
        115                 120                 125             


Arg Ser Gln Gly Pro Gly Gly Lys Ile Val Thr Cys Ala His Arg Tyr 
    130                 135                 140                 


Glu Ala Arg Gln Arg Val Asp Gln Ile Leu Glu Thr Arg Asp Met Ile 
145                 150                 155                 160 


Gly Arg Cys Phe Val Leu Ser Gln Asp Leu Ala Ile Arg Asp Glu Leu 
                165                 170                 175     


Asp Gly Gly Glu Trp Lys Phe Cys Glu Gly Arg Pro Gln Gly His Glu 
            180                 185                 190         


Gln Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Ala Phe Ser Pro Asp 
        195                 200                 205             


Ser His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly 
    210                 215                 220                 


Thr Ala Arg Val Glu Leu Cys Ala Gln Gly Ser Ala Asp Leu Ala His 
225                 230                 235                 240 


Leu Asp Asp Gly Pro Tyr Glu Ala Gly Gly Glu Lys Glu Gln Asp Pro 
                245                 250                 255     


Arg Leu Ile Pro Val Pro Ala Asn Ser Tyr Phe Gly Leu Leu Phe Val 
            260                 265                 270         


Thr Asn Ile Asp Ser Ser Asp Pro Asp Gln Leu Val Tyr Lys Thr Leu 
        275                 280                 285             


Asp Pro Ala Asp Arg Leu Pro Gly Pro Ala Gly Asp Leu Ala Leu Asn 
    290                 295                 300                 


Ser Tyr Leu Gly Phe Ser Ile Asp Ser Gly Lys Gly Leu Val Arg Ala 
305                 310                 315                 320 


Glu Glu Leu Ser Phe Val Ala Gly Ala Pro Arg Ala Asn His Lys Gly 
                325                 330                 335     


Ala Val Val Ile Leu Arg Lys Asp Ser Ala Ser Arg Leu Val Pro Glu 
            340                 345                 350         


Val Met Leu Ser Gly Glu Arg Leu Thr Ser Gly Phe Gly Tyr Ser Leu 
        355                 360                 365             


Ala Val Ala Asp Leu Asn Ser Asp Gly Trp Pro Asp Leu Ile Val Gly 
    370                 375                 380                 


Ala Pro Tyr Phe Phe Glu Arg Gln Glu Glu Leu Gly Gly Ala Val Tyr 
385                 390                 395                 400 


Val Tyr Leu Asn Gln Gly Gly His Trp Ala Gly Ile Ser Pro Leu Arg 
                405                 410                 415     


Leu Cys Gly Ser Pro Asp Ser Met Phe Gly Ile Ser Leu Ala Val Leu 
            420                 425                 430         


Gly Asp Leu Asn Gln Asp Gly Phe Pro Asp Ile Ala Val Gly Ala Pro 
        435                 440                 445             


Phe Asp Gly Asp Gly Lys Val Phe Ile Tyr His Gly Ser Ser Leu Gly 
    450                 455                 460                 


Val Val Ala Lys Pro Ser Gln Val Leu Glu Gly Glu Ala Val Gly Ile 
465                 470                 475                 480 


Lys Ser Phe Gly Tyr Ser Leu Ser Gly Ser Leu Asp Met Asp Gly Asn 
                485                 490                 495     


Gln Tyr Pro Asp Leu Leu Val Gly Ser Leu Ala Asp Thr Ala Val Leu 
            500                 505                 510         


Phe Arg Ala Arg Pro Ile Leu His Val Ser His Glu Val Ser Ile Ala 
        515                 520                 525             


Pro Arg Ser Ile Asp Leu Glu Gln Pro Asn Cys Ala Gly Gly His Ser 
    530                 535                 540                 


Val Cys Val Asp Leu Arg Val Cys Phe Ser Tyr Ile Ala Val Pro Ser 
545                 550                 555                 560 


Ser Tyr Ser Pro Thr Val Ala Leu Asp Tyr Val Leu Asp Ala Asp Thr 
                565                 570                 575     


Asp Arg Arg Leu Arg Gly Gln Val Pro Arg Val Thr Phe Leu Ser Arg 
            580                 585                 590         


Asn Leu Glu Glu Pro Lys His Gln Ala Ser Gly Thr Val Trp Leu Lys 
        595                 600                 605             


His Gln His Asp Arg Val Cys Gly Asp Ala Met Phe Gln Leu Gln Glu 
    610                 615                 620                 


Asn Val Lys Asp Lys Leu Arg Ala Ile Val Val Thr Leu Ser Tyr Ser 
625                 630                 635                 640 


Leu Gln Thr Pro Arg Leu Arg Arg Gln Ala Pro Gly Gln Gly Leu Pro 
                645                 650                 655     


Pro Val Ala Pro Ile Leu Asn Ala His Gln Pro Ser Thr Gln Arg Ala 
            660                 665                 670         


Glu Ile His Phe Leu Lys Gln Gly Cys Gly Glu Asp Lys Ile Cys Gln 
        675                 680                 685             


Ser Asn Leu Gln Leu Val Arg Ala Arg Phe Cys Thr Arg Val Ser Asp 
    690                 695                 700                 


Thr Glu Phe Gln Pro Leu Pro Met Asp Val Asp Gly Thr Thr Ala Leu 
705                 710                 715                 720 


Phe Ala Leu Ser Gly Gln Pro Val Ile Gly Leu Glu Leu Met Val Thr 
                725                 730                 735     


Asn Leu Pro Ser Asp Pro Ala Gln Pro Gln Ala Asp Gly Asp Asp Ala 
            740                 745                 750         


His Glu Ala Gln Leu Leu Val Met Leu Pro Asp Ser Leu His Tyr Ser 
        755                 760                 765             


Gly Val Arg Ala Leu Asp Pro Ala Glu Lys Pro Leu Cys Leu Ser Asn 
    770                 775                 780                 


Glu Asn Ala Ser His Val Glu Cys Glu Leu Gly Asn Pro Met Lys Arg 
785                 790                 795                 800 


Gly Ala Gln Val Thr Phe Tyr Leu Ile Leu Ser Thr Ser Gly Ile Ser 
                805                 810                 815     


Ile Glu Thr Thr Glu Leu Glu Val Glu Leu Leu Leu Ala Thr Ile Ser 
            820                 825                 830         


Glu Gln Glu Leu His Pro Val Ser Ala Arg Ala Arg Val Phe Ile Glu 
        835                 840                 845             


Leu Pro Leu Ser Ile Ala Gly Met Ala Ile Pro Gln Gln Leu Phe Phe 
    850                 855                 860                 


Ser Gly Val Val Arg Gly Glu Arg Ala Met Gln Ser Glu Arg Asp Val 
865                 870                 875                 880 


Gly Ser Lys Val Lys Tyr Glu Val Thr Val Ser Asn Gln Gly Gln Ser 
                885                 890                 895     


Leu Arg Thr Leu Gly Ser Ala Phe Leu Asn Ile Met Trp Pro His Glu 
            900                 905                 910         


Ile Ala Asn Gly Lys Trp Leu Leu Tyr Pro Met Gln Val Glu Leu Glu 
        915                 920                 925             


Gly Gly Gln Gly Pro Gly Gln Lys Gly Leu Cys Ser Pro Arg Pro Asn 
    930                 935                 940                 


Ile Leu His Leu Asp Val Asp Ser Arg Asp Arg Arg Arg Arg Glu Leu 
945                 950                 955                 960 


Glu Pro Pro Glu Gln Gln Glu Pro Gly Glu Arg Gln Glu Pro Ser Met 
                965                 970                 975     


Ser Trp Trp Pro Val Ser Ser Ala Glu Lys Lys Lys Asn Ile Thr Leu 
            980                 985                 990         


Asp Cys Ala Arg Gly Thr Ala Asn  Cys Val Val Phe Ser  Cys Pro Leu 
        995                 1000                 1005             


Tyr Ser  Phe Asp Arg Ala Ala  Val Leu His Val Trp  Gly Arg Leu 
    1010                 1015                 1020             


Trp Asn  Ser Thr Phe Leu Glu  Glu Tyr Ser Ala Val  Lys Ser Leu 
    1025                 1030                 1035             


Glu Val  Ile Val Arg Ala Asn  Ile Thr Val Lys Ser  Ser Ile Lys 
    1040                 1045                 1050             


Asn Leu  Met Leu Arg Asp Ala  Ser Thr Val Ile Pro  Val Met Val 
    1055                 1060                 1065             


Tyr Leu  Asp Pro Met Ala Val  Val Ala Glu Gly Val  Pro Trp Trp 
    1070                 1075                 1080             


Val Ile  Leu Leu Ala Val Leu  Ala Gly Leu Leu Val  Leu Ala Leu 
    1085                 1090                 1095             


Leu Val  Leu Leu Leu Trp Lys  Met Gly Phe Phe Lys  Arg Ala Lys 
    1100                 1105                 1110             


His Pro  Glu Ala Thr Val Pro  Gln Tyr His Ala Val  Lys Ile Pro 
    1115                 1120                 1125             


Arg Glu  Asp Arg Gln Gln Phe  Lys Glu Glu Lys Thr  Gly Thr Ile 
    1130                 1135                 1140             


Leu Arg  Asn Asn Trp Gly Ser  Pro Arg Arg Glu Gly  Pro Asp Ala 
    1145                 1150                 1155             


His Pro  Ile Leu Ala Ala Asp  Gly His Pro Glu Leu  Gly Pro Asp 
    1160                 1165                 1170             


Gly His  Pro Gly Pro Gly Thr  Ala 
    1175                 1180     


<210>  76
<211>  1063
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Pro Gly Ala Ser Arg Gly Pro Arg Gly Ser Gln Ala Pro Leu 
1               5                   10                  15      


Ile Ala Pro Leu Cys Cys Ala Ala Ala Ala Leu Gly Met Leu Leu Trp 
            20                  25                  30          


Ser Pro Ala Cys Gln Ala Phe Asn Leu Asp Val Glu Lys Leu Thr Val 
        35                  40                  45              


Tyr Ser Gly Pro Lys Gly Ser Tyr Phe Gly Tyr Ala Val Asp Phe His 
    50                  55                  60                  


Ile Pro Asp Ala Arg Thr Ala Ser Val Leu Val Gly Ala Pro Lys Ala 
65                  70                  75                  80  


Asn Thr Ser Gln Pro Asp Ile Val Glu Gly Gly Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Trp Pro Ala Glu Gly Ser Ala Gln Cys Arg Gln Ile Pro Phe Asp 
            100                 105                 110         


Thr Thr Asn Asn Arg Lys Ile Arg Val Asn Gly Thr Lys Glu Pro Ile 
        115                 120                 125             


Glu Phe Lys Ser Asn Gln Trp Phe Gly Ala Thr Val Lys Ala His Lys 
    130                 135                 140                 


Gly Lys Val Val Ala Cys Ala Pro Leu Tyr His Trp Arg Thr Leu Lys 
145                 150                 155                 160 


Pro Thr Pro Glu Lys Asp Pro Val Gly Thr Cys Tyr Val Ala Ile Gln 
                165                 170                 175     


Asn Phe Ser Ala Tyr Ala Glu Phe Ser Pro Cys Arg Asn Ser Asn Ala 
            180                 185                 190         


Asp Pro Glu Gly Gln Gly Tyr Cys Gln Ala Gly Phe Ser Leu Asp Phe 
        195                 200                 205             


Tyr Lys Asn Gly Asp Leu Ile Val Gly Gly Pro Gly Ser Phe Tyr Trp 
    210                 215                 220                 


Gln Gly Gln Val Ile Thr Ala Ser Val Ala Asp Ile Ile Ala Asn Tyr 
225                 230                 235                 240 


Ser Phe Lys Asp Ile Leu Arg Lys Leu Ala Gly Glu Lys Gln Thr Glu 
                245                 250                 255     


Val Ala Pro Ala Ser Tyr Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala 
            260                 265                 270         


Ala Gly Glu Phe Thr Gly Asp Ser Gln Gln Glu Leu Val Ala Gly Ile 
        275                 280                 285             


Pro Arg Gly Ala Gln Asn Phe Gly Tyr Val Ser Ile Ile Asn Ser Thr 
    290                 295                 300                 


Asp Met Thr Phe Ile Gln Asn Phe Thr Gly Glu Gln Met Ala Ser Tyr 
305                 310                 315                 320 


Phe Gly Tyr Thr Val Val Val Ser Asp Val Asn Ser Asp Gly Leu Asp 
                325                 330                 335     


Asp Val Leu Val Gly Ala Pro Leu Phe Met Glu Arg Glu Phe Glu Ser 
            340                 345                 350         


Asn Pro Arg Glu Val Gly Gln Ile Tyr Leu Tyr Leu Gln Val Ser Ser 
        355                 360                 365             


Leu Leu Phe Arg Asp Pro Gln Ile Leu Thr Gly Thr Glu Thr Phe Gly 
    370                 375                 380                 


Arg Phe Gly Ser Ala Met Ala His Leu Gly Asp Leu Asn Gln Asp Gly 
385                 390                 395                 400 


Tyr Asn Asp Ile Ala Ile Gly Val Pro Phe Ala Gly Lys Asp Gln Arg 
                405                 410                 415     


Gly Lys Val Leu Ile Tyr Asn Gly Asn Lys Asp Gly Leu Asn Thr Lys 
            420                 425                 430         


Pro Ser Gln Val Leu Gln Gly Val Trp Ala Ser His Ala Val Pro Ser 
        435                 440                 445             


Gly Phe Gly Phe Thr Leu Arg Gly Asp Ser Asp Ile Asp Lys Asn Asp 
    450                 455                 460                 


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Thr Gly Lys Val Ala Val 
465                 470                 475                 480 


Tyr Arg Ala Arg Pro Val Val Thr Val Asp Ala Gln Leu Leu Leu His 
                485                 490                 495     


Pro Met Ile Ile Asn Leu Glu Asn Lys Thr Cys Gln Val Pro Asp Ser 
            500                 505                 510         


Met Thr Ser Ala Ala Cys Phe Ser Leu Arg Val Cys Ala Ser Val Thr 
        515                 520                 525             


Gly Gln Ser Ile Ala Asn Thr Ile Val Leu Met Ala Glu Val Gln Leu 
    530                 535                 540                 


Asp Ser Leu Lys Gln Lys Gly Ala Ile Lys Arg Thr Leu Phe Leu Asp 
545                 550                 555                 560 


Asn His Gln Ala His Arg Val Phe Pro Leu Val Ile Lys Arg Gln Lys 
                565                 570                 575     


Ser His Gln Cys Gln Asp Phe Ile Val Tyr Leu Arg Asp Glu Thr Glu 
            580                 585                 590         


Phe Arg Asp Lys Leu Ser Pro Ile Asn Ile Ser Leu Asn Tyr Ser Leu 
        595                 600                 605             


Asp Glu Ser Thr Phe Lys Glu Gly Leu Glu Val Lys Pro Ile Leu Asn 
    610                 615                 620                 


Tyr Tyr Arg Glu Asn Ile Val Ser Glu Gln Ala His Ile Leu Val Asp 
625                 630                 635                 640 


Cys Gly Glu Asp Asn Leu Cys Val Pro Asp Leu Lys Leu Ser Ala Arg 
                645                 650                 655     


Pro Asp Lys His Gln Val Ile Ile Gly Asp Glu Asn His Leu Met Leu 
            660                 665                 670         


Ile Ile Asn Ala Arg Asn Glu Gly Glu Gly Ala Tyr Glu Ala Glu Leu 
        675                 680                 685             


Phe Val Met Ile Pro Glu Glu Ala Asp Tyr Val Gly Ile Glu Arg Asn 
    690                 695                 700                 


Asn Lys Gly Phe Arg Pro Leu Ser Cys Glu Tyr Lys Met Glu Asn Val 
705                 710                 715                 720 


Thr Arg Met Val Val Cys Asp Leu Gly Asn Pro Met Val Ser Gly Thr 
                725                 730                 735     


Asn Tyr Ser Leu Gly Leu Arg Phe Ala Val Pro Arg Leu Glu Lys Thr 
            740                 745                 750         


Asn Met Ser Ile Asn Phe Asp Leu Gln Ile Arg Ser Ser Asn Lys Asp 
        755                 760                 765             


Asn Pro Asp Ser Asn Phe Val Ser Leu Gln Ile Asn Ile Thr Ala Val 
    770                 775                 780                 


Ala Gln Val Glu Ile Arg Gly Val Ser His Pro Pro Gln Ile Val Leu 
785                 790                 795                 800 


Pro Ile His Asn Trp Glu Pro Glu Glu Glu Pro His Lys Glu Glu Glu 
                805                 810                 815     


Val Gly Pro Leu Val Glu His Ile Tyr Glu Leu His Asn Ile Gly Pro 
            820                 825                 830         


Ser Thr Ile Ser Asp Thr Ile Leu Glu Val Gly Trp Pro Phe Ser Ala 
        835                 840                 845             


Arg Asp Glu Phe Leu Leu Tyr Ile Phe His Ile Gln Thr Leu Gly Pro 
    850                 855                 860                 


Leu Gln Cys Gln Pro Asn Pro Asn Ile Asn Pro Gln Asp Ile Lys Pro 
865                 870                 875                 880 


Ala Ala Ser Pro Glu Asp Thr Pro Glu Leu Ser Ala Phe Leu Arg Asn 
                885                 890                 895     


Ser Thr Ile Pro His Leu Val Arg Lys Arg Asp Val His Val Val Glu 
            900                 905                 910         


Phe His Arg Gln Ser Pro Ala Lys Ile Leu Asn Cys Thr Asn Ile Glu 
        915                 920                 925             


Cys Leu Gln Ile Ser Cys Ala Val Gly Arg Leu Glu Gly Gly Glu Ser 
    930                 935                 940                 


Ala Val Leu Lys Val Arg Ser Arg Leu Trp Ala His Thr Phe Leu Gln 
945                 950                 955                 960 


Arg Lys Asn Asp Pro Tyr Ala Leu Ala Ser Leu Val Ser Phe Glu Val 
                965                 970                 975     


Lys Lys Met Pro Tyr Thr Asp Gln Pro Ala Lys Leu Pro Glu Gly Ser 
            980                 985                 990         


Ile Val Ile Lys Thr Ser Val Ile  Trp Ala Thr Pro Asn  Val Ser Phe 
        995                 1000                 1005             


Ser Ile  Pro Leu Trp Val Ile  Ile Leu Ala Ile Leu  Leu Gly Leu 
    1010                 1015                 1020             


Leu Val  Leu Ala Ile Leu Thr  Leu Ala Leu Trp Lys  Cys Gly Phe 
    1025                 1030                 1035             


Phe Asp  Arg Ala Arg Pro Pro  Gln Glu Asp Met Thr  Asp Arg Glu 
    1040                 1045                 1050             


Gln Leu  Thr Asn Asp Lys Thr  Pro Glu Ala 
    1055                 1060             


<210>  77
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Gly Pro Ala Ala Pro Arg Gly Ala Gly Arg Leu Arg Ala Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Val Ala Gly Ile Pro Ala Gly Ala Tyr Asn Leu 
            20                  25                  30          


Asp Pro Gln Arg Pro Val His Phe Gln Gly Pro Ala Asp Ser Phe Phe 
        35                  40                  45              


Gly Tyr Ala Val Leu Glu His Phe His Asp Asn Thr Arg Trp Val Leu 
    50                  55                  60                  


Val Gly Ala Pro Lys Ala Asp Ser Lys Tyr Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Pro Gly Ala Val Phe Lys Cys Arg Val His Thr Asn Pro Asp Arg Arg 
                85                  90                  95      


Cys Thr Glu Leu Asp Met Ala Arg Gly Lys Asn Arg Gly Thr Ser Cys 
            100                 105                 110         


Gly Lys Thr Cys Arg Glu Asp Arg Asp Asp Glu Trp Met Gly Val Ser 
        115                 120                 125             


Leu Ala Arg Gln Pro Lys Ala Asp Gly Arg Val Leu Ala Cys Ala His 
    130                 135                 140                 


Arg Trp Lys Asn Ile Tyr Tyr Glu Ala Asp His Ile Leu Pro His Gly 
145                 150                 155                 160 


Phe Cys Tyr Ile Ile Pro Ser Asn Leu Gln Ala Lys Gly Arg Thr Leu 
                165                 170                 175     


Ile Pro Cys Tyr Glu Glu Tyr Lys Lys Lys Tyr Gly Glu Glu His Gly 
            180                 185                 190         


Ser Cys Gln Ala Gly Ile Ala Gly Phe Phe Thr Glu Glu Leu Val Val 
        195                 200                 205             


Met Gly Ala Pro Gly Ser Phe Tyr Trp Ala Gly Thr Ile Lys Val Leu 
    210                 215                 220                 


Asn Leu Thr Asp Asn Thr Tyr Leu Lys Leu Asn Asp Glu Val Ile Met 
225                 230                 235                 240 


Asn Arg Arg Tyr Thr Tyr Leu Gly Tyr Ala Val Thr Ala Gly His Phe 
                245                 250                 255     


Ser His Pro Ser Thr Ile Asp Val Val Gly Gly Ala Pro Gln Asp Lys 
            260                 265                 270         


Gly Ile Gly Lys Val Tyr Ile Phe Arg Ala Asp Arg Arg Ser Gly Thr 
        275                 280                 285             


Leu Ile Lys Ile Phe Gln Ala Ser Gly Lys Lys Met Gly Ser Tyr Phe 
    290                 295                 300                 


Gly Ser Ser Leu Cys Ala Val Asp Leu Asn Gly Asp Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Leu Val Gly Ala Pro Met Phe Ser Glu Ile Arg Asp Glu Gly Gln 
                325                 330                 335     


Val Thr Val Tyr Ile Asn Arg Gly Asn Gly Ala Leu Glu Glu Gln Leu 
            340                 345                 350         


Ala Leu Thr Gly Asp Gly Ala Tyr Asn Ala His Phe Gly Glu Ser Ile 
        355                 360                 365             


Ala Ser Leu Asp Asp Leu Asp Asn Asp Gly Phe Pro Asp Val Ala Ile 
    370                 375                 380                 


Gly Ala Pro Lys Glu Asp Asp Phe Ala Gly Ala Val Tyr Ile Tyr His 
385                 390                 395                 400 


Gly Asp Ala Gly Gly Ile Val Pro Gln Tyr Ser Met Lys Leu Ser Gly 
                405                 410                 415     


Gln Lys Ile Asn Pro Val Leu Arg Met Phe Gly Gln Ser Ile Ser Gly 
            420                 425                 430         


Gly Ile Asp Met Asp Gly Asn Gly Tyr Pro Asp Val Thr Val Gly Ala 
        435                 440                 445             


Phe Met Ser Asp Ser Val Val Leu Leu Arg Ala Arg Pro Val Ile Thr 
    450                 455                 460                 


Val Asp Val Ser Ile Phe Leu Pro Gly Ser Ile Asn Ile Thr Ala Pro 
465                 470                 475                 480 


Gln Cys His Asp Gly Gln Gln Pro Val Asn Cys Leu Asn Val Thr Thr 
                485                 490                 495     


Cys Phe Ser Phe His Gly Lys His Val Pro Gly Glu Ile Gly Leu Asn 
            500                 505                 510         


Tyr Val Leu Met Ala Asp Val Ala Lys Lys Glu Lys Gly Gln Met Pro 
        515                 520                 525             


Arg Val Tyr Phe Val Leu Leu Gly Glu Thr Met Gly Gln Val Thr Glu 
    530                 535                 540                 


Lys Leu Gln Leu Thr Tyr Met Glu Glu Thr Cys Arg His Tyr Val Ala 
545                 550                 555                 560 


His Val Lys Arg Arg Val Gln Asp Val Ile Ser Pro Ile Val Phe Glu 
                565                 570                 575     


Ala Ala Tyr Ser Leu Ser Glu His Val Thr Gly Glu Glu Glu Arg Glu 
            580                 585                 590         


Leu Pro Pro Leu Thr Pro Val Leu Arg Trp Lys Lys Gly Gln Lys Ile 
        595                 600                 605             


Ala Gln Lys Asn Gln Thr Val Phe Glu Arg Asn Cys Arg Ser Glu Asp 
    610                 615                 620                 


Cys Ala Ala Asp Leu Gln Leu Gln Gly Lys Leu Leu Leu Ser Ser Met 
625                 630                 635                 640 


Asp Glu Lys Thr Leu Tyr Leu Ala Leu Gly Ala Val Lys Asn Ile Ser 
                645                 650                 655     


Leu Asn Ile Ser Ile Ser Asn Leu Gly Asp Asp Ala Tyr Asp Ala Asn 
            660                 665                 670         


Val Ser Phe Asn Val Ser Arg Glu Leu Phe Phe Ile Asn Met Trp Gln 
        675                 680                 685             


Lys Glu Glu Met Gly Ile Ser Cys Glu Leu Leu Glu Ser Asp Phe Leu 
    690                 695                 700                 


Lys Cys Ser Val Gly Phe Pro Phe Met Arg Ser Lys Ser Lys Tyr Glu 
705                 710                 715                 720 


Phe Ser Val Ile Phe Asp Thr Ser His Leu Ser Gly Glu Glu Glu Val 
                725                 730                 735     


Leu Ser Phe Ile Val Thr Ala Gln Ser Gly Asn Thr Glu Arg Ser Glu 
            740                 745                 750         


Ser Leu His Asp Asn Thr Leu Val Leu Met Val Pro Leu Met His Glu 
        755                 760                 765             


Val Asp Thr Ser Ile Thr Gly Ile Met Ser Pro Thr Ser Phe Val Tyr 
    770                 775                 780                 


Gly Glu Ser Val Asp Ala Ala Asn Phe Ile Gln Leu Asp Asp Leu Glu 
785                 790                 795                 800 


Cys His Phe Gln Pro Ile Asn Ile Thr Leu Gln Val Tyr Asn Thr Gly 
                805                 810                 815     


Pro Ser Thr Leu Pro Gly Ser Ser Val Ser Ile Ser Phe Pro Asn Arg 
            820                 825                 830         


Leu Ser Ser Gly Gly Ala Glu Met Phe His Val Gln Glu Met Val Val 
        835                 840                 845             


Gly Gln Glu Lys Gly Asn Cys Ser Phe Gln Lys Asn Pro Thr Pro Cys 
    850                 855                 860                 


Ile Ile Pro Gln Glu Gln Glu Asn Ile Phe His Thr Ile Phe Ala Phe 
865                 870                 875                 880 


Phe Thr Lys Ser Gly Arg Lys Val Leu Asp Cys Glu Lys Pro Gly Ile 
                885                 890                 895     


Ser Cys Leu Thr Ala His Cys Asn Phe Ser Ala Leu Ala Lys Glu Glu 
            900                 905                 910         


Ser Arg Thr Ile Asp Ile Tyr Met Leu Leu Asn Thr Glu Ile Leu Lys 
        915                 920                 925             


Lys Asp Ser Ser Ser Val Ile Gln Phe Met Ser Arg Ala Lys Val Lys 
    930                 935                 940                 


Val Asp Pro Ala Leu Arg Val Val Glu Ile Ala His Gly Asn Pro Glu 
945                 950                 955                 960 


Glu Val Thr Val Val Phe Glu Ala Leu His Asn Leu Glu Pro Arg Gly 
                965                 970                 975     


Tyr Val Val Gly Trp Ile Ile Ala Ile Ser Leu Leu Val Gly Ile Leu 
            980                 985                 990         


Ile Phe Leu Leu Leu Ala Val Leu  Leu Trp Lys Met Gly  Phe Phe Arg 
        995                 1000                 1005             


Arg Arg  Tyr Lys Glu Ile Ile  Glu Ala Glu Lys Asn  Arg Lys Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ser Trp Asp Trp  Val Gln Lys Asn Gln  
    1025                 1030                 1035 


<210>  78
<211>  1167
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Leu Pro Phe Val Thr His Leu Phe Leu Pro Leu Val Phe Leu 
1               5                   10                  15      


Thr Gly Leu Cys Ser Pro Phe Asn Leu Asp Glu His His Pro Arg Leu 
            20                  25                  30          


Phe Pro Gly Pro Pro Glu Ala Glu Phe Gly Tyr Ser Val Leu Gln His 
        35                  40                  45              


Val Gly Gly Gly Gln Arg Trp Met Leu Val Gly Ala Pro Trp Asp Gly 
    50                  55                  60                  


Pro Ser Gly Asp Arg Arg Gly Asp Val Tyr Arg Cys Pro Val Gly Gly 
65                  70                  75                  80  


Ala His Asn Ala Pro Cys Ala Lys Gly His Leu Gly Asp Tyr Gln Leu 
                85                  90                  95      


Gly Asn Ser Ser His Pro Ala Val Asn Met His Leu Gly Met Ser Leu 
            100                 105                 110         


Leu Glu Thr Asp Gly Asp Gly Gly Phe Met Ala Cys Ala Pro Leu Trp 
        115                 120                 125             


Ser Arg Ala Cys Gly Ser Ser Val Phe Ser Ser Gly Ile Cys Ala Arg 
    130                 135                 140                 


Val Asp Ala Ser Phe Gln Pro Gln Gly Ser Leu Ala Pro Thr Ala Gln 
145                 150                 155                 160 


Arg Cys Pro Thr Tyr Met Asp Val Val Ile Val Leu Asp Gly Ser Asn 
                165                 170                 175     


Ser Ile Tyr Pro Trp Ser Glu Val Gln Thr Phe Leu Arg Arg Leu Val 
            180                 185                 190         


Gly Lys Leu Phe Ile Asp Pro Glu Gln Ile Gln Val Gly Leu Val Gln 
        195                 200                 205             


Tyr Gly Glu Ser Pro Val His Glu Trp Ser Leu Gly Asp Phe Arg Thr 
    210                 215                 220                 


Lys Glu Glu Val Val Arg Ala Ala Lys Asn Leu Ser Arg Arg Glu Gly 
225                 230                 235                 240 


Arg Glu Thr Lys Thr Ala Gln Ala Ile Met Val Ala Cys Thr Glu Gly 
                245                 250                 255     


Phe Ser Gln Ser His Gly Gly Arg Pro Glu Ala Ala Arg Leu Leu Val 
            260                 265                 270         


Val Val Thr Asp Gly Glu Ser His Asp Gly Glu Glu Leu Pro Ala Ala 
        275                 280                 285             


Leu Lys Ala Cys Glu Ala Gly Arg Val Thr Arg Tyr Gly Ile Ala Val 
    290                 295                 300                 


Leu Gly His Tyr Leu Arg Arg Gln Arg Asp Pro Ser Ser Phe Leu Arg 
305                 310                 315                 320 


Glu Ile Arg Thr Ile Ala Ser Asp Pro Asp Glu Arg Phe Phe Phe Asn 
                325                 330                 335     


Val Thr Asp Glu Ala Ala Leu Thr Asp Ile Val Asp Ala Leu Gly Asp 
            340                 345                 350         


Arg Ile Phe Gly Leu Glu Gly Ser His Ala Glu Asn Glu Ser Ser Phe 
        355                 360                 365             


Gly Leu Glu Met Ser Gln Ile Gly Phe Ser Thr His Arg Leu Lys Asp 
    370                 375                 380                 


Gly Ile Leu Phe Gly Met Val Gly Ala Tyr Asp Trp Gly Gly Ser Val 
385                 390                 395                 400 


Leu Trp Leu Glu Gly Gly His Arg Leu Phe Pro Pro Arg Met Ala Leu 
                405                 410                 415     


Glu Asp Glu Phe Pro Pro Ala Leu Gln Asn His Ala Ala Tyr Leu Gly 
            420                 425                 430         


Tyr Ser Val Ser Ser Met Leu Leu Arg Gly Gly Arg Arg Leu Phe Leu 
        435                 440                 445             


Ser Gly Ala Pro Arg Phe Arg His Arg Gly Lys Val Ile Ala Phe Gln 
    450                 455                 460                 


Leu Lys Lys Asp Gly Ala Val Arg Val Ala Gln Ser Leu Gln Gly Glu 
465                 470                 475                 480 


Gln Ile Gly Ser Tyr Phe Gly Ser Glu Leu Cys Pro Leu Asp Thr Asp 
                485                 490                 495     


Arg Asp Gly Thr Thr Asp Val Leu Leu Val Ala Ala Pro Met Phe Leu 
            500                 505                 510         


Gly Pro Gln Asn Lys Glu Thr Gly Arg Val Tyr Val Tyr Leu Val Gly 
        515                 520                 525             


Gln Gln Ser Leu Leu Thr Leu Gln Gly Thr Leu Gln Pro Glu Pro Pro 
    530                 535                 540                 


Gln Asp Ala Arg Phe Gly Phe Ala Met Gly Ala Leu Pro Asp Leu Asn 
545                 550                 555                 560 


Gln Asp Gly Phe Ala Asp Val Ala Val Gly Ala Pro Leu Glu Asp Gly 
                565                 570                 575     


His Gln Gly Ala Leu Tyr Leu Tyr His Gly Thr Gln Ser Gly Val Arg 
            580                 585                 590         


Pro His Pro Ala Gln Arg Ile Ala Ala Ala Ser Met Pro His Ala Leu 
        595                 600                 605             


Ser Tyr Phe Gly Arg Ser Val Asp Gly Arg Leu Asp Leu Asp Gly Asp 
    610                 615                 620                 


Asp Leu Val Asp Val Ala Val Gly Ala Gln Gly Ala Ala Ile Leu Leu 
625                 630                 635                 640 


Ser Ser Arg Pro Ile Val His Leu Thr Pro Ser Leu Glu Val Thr Pro 
                645                 650                 655     


Gln Ala Ile Ser Val Val Gln Arg Asp Cys Arg Arg Arg Gly Gln Glu 
            660                 665                 670         


Ala Val Cys Leu Thr Ala Ala Leu Cys Phe Gln Val Thr Ser Arg Thr 
        675                 680                 685             


Pro Gly Arg Trp Asp His Gln Phe Tyr Met Arg Phe Thr Ala Ser Leu 
    690                 695                 700                 


Asp Glu Trp Thr Ala Gly Ala Arg Ala Ala Phe Asp Gly Ser Gly Gln 
705                 710                 715                 720 


Arg Leu Ser Pro Arg Arg Leu Arg Leu Ser Val Gly Asn Val Thr Cys 
                725                 730                 735     


Glu Gln Leu His Phe His Val Leu Asp Thr Ser Asp Tyr Leu Arg Pro 
            740                 745                 750         


Val Ala Leu Thr Val Thr Phe Ala Leu Asp Asn Thr Thr Lys Pro Gly 
        755                 760                 765             


Pro Val Leu Asn Glu Gly Ser Pro Thr Ser Ile Gln Lys Leu Val Pro 
    770                 775                 780                 


Phe Ser Lys Asp Cys Gly Pro Asp Asn Glu Cys Val Thr Asp Leu Val 
785                 790                 795                 800 


Leu Gln Val Asn Met Asp Ile Arg Gly Ser Arg Lys Ala Pro Phe Val 
                805                 810                 815     


Val Arg Gly Gly Arg Arg Lys Val Leu Val Ser Thr Thr Leu Glu Asn 
            820                 825                 830         


Arg Lys Glu Asn Ala Tyr Asn Thr Ser Leu Ser Leu Ile Phe Ser Arg 
        835                 840                 845             


Asn Leu His Leu Ala Ser Leu Thr Pro Gln Arg Glu Ser Pro Ile Lys 
    850                 855                 860                 


Val Glu Cys Ala Ala Pro Ser Ala His Ala Arg Leu Cys Ser Val Gly 
865                 870                 875                 880 


His Pro Val Phe Gln Thr Gly Ala Lys Val Thr Phe Leu Leu Glu Phe 
                885                 890                 895     


Glu Phe Ser Cys Ser Ser Leu Leu Ser Gln Val Phe Val Lys Leu Thr 
            900                 905                 910         


Ala Ser Ser Asp Ser Leu Glu Arg Asn Gly Thr Leu Gln Asp Asn Thr 
        915                 920                 925             


Ala Gln Thr Ser Ala Tyr Ile Gln Tyr Glu Pro His Leu Leu Phe Ser 
    930                 935                 940                 


Ser Glu Ser Thr Leu His Arg Tyr Glu Val His Pro Tyr Gly Thr Leu 
945                 950                 955                 960 


Pro Val Gly Pro Gly Pro Glu Phe Lys Thr Thr Leu Arg Val Gln Asn 
                965                 970                 975     


Leu Gly Cys Tyr Val Val Ser Gly Leu Ile Ile Ser Ala Leu Leu Pro 
            980                 985                 990         


Ala Val Ala His Gly Gly Asn Tyr  Phe Leu Ser Leu Ser  Gln Val Ile 
        995                 1000                 1005             


Thr Asn  Asn Ala Ser Cys Ile  Val Gln Asn Leu Thr  Glu Pro Pro 
    1010                 1015                 1020             


Gly Pro  Pro Val His Pro Glu  Glu Leu Gln His Thr  Asn Arg Leu 
    1025                 1030                 1035             


Asn Gly  Ser Asn Thr Gln Cys  Gln Val Val Arg Cys  His Leu Gly 
    1040                 1045                 1050             


Gln Leu  Ala Lys Gly Thr Glu  Val Ser Val Gly Leu  Leu Arg Leu 
    1055                 1060                 1065             


Val His  Asn Glu Phe Phe Arg  Arg Ala Lys Phe Lys  Ser Leu Thr 
    1070                 1075                 1080             


Val Val  Ser Thr Phe Glu Leu  Gly Thr Glu Glu Gly  Ser Val Leu 
    1085                 1090                 1095             


Gln Leu  Thr Glu Ala Ser Arg  Trp Ser Glu Ser Leu  Leu Glu Val 
    1100                 1105                 1110             


Val Gln  Thr Arg Pro Ile Leu  Ile Ser Leu Trp Ile  Leu Ile Gly 
    1115                 1120                 1125             


Ser Val  Leu Gly Gly Leu Leu  Leu Leu Ala Leu Leu  Val Phe Cys 
    1130                 1135                 1140             


Leu Trp  Lys Leu Gly Phe Phe  Ala His Lys Lys Ile  Pro Glu Glu 
    1145                 1150                 1155             


Glu Lys  Arg Glu Glu Lys Leu  Glu Gln 
    1160                 1165         


<210>  79
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Asp Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp 
1               5                   10                  15      


Pro Gly Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val 
            20                  25                  30          


Ile Pro Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His 
        35                  40                  45              


Asp Ile Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His 
65                  70                  75                  80  


Gly Asn Cys Thr Lys Leu Asn Leu Gly Arg Val Thr Leu Ser Asn Val 
                85                  90                  95      


Ser Glu Arg Lys Asp Asn Met Arg Leu Gly Leu Ser Leu Ala Thr Asn 
            100                 105                 110         


Pro Lys Asp Asn Ser Phe Leu Ala Cys Ser Pro Leu Trp Ser His Glu 
        115                 120                 125             


Cys Gly Ser Ser Tyr Tyr Thr Thr Gly Met Cys Ser Arg Val Asn Ser 
    130                 135                 140                 


Asn Phe Arg Phe Ser Lys Thr Val Ala Pro Ala Leu Gln Arg Cys Gln 
145                 150                 155                 160 


Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr 
                165                 170                 175     


Pro Trp Val Glu Val Gln His Phe Leu Ile Asn Ile Leu Lys Lys Phe 
            180                 185                 190         


Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val Val Gln Tyr Gly Glu 
        195                 200                 205             


Asp Val Val His Glu Phe His Leu Asn Asp Tyr Arg Ser Val Lys Asp 
    210                 215                 220                 


Val Val Glu Ala Ala Ser His Ile Glu Gln Arg Gly Gly Thr Glu Thr 
225                 230                 235                 240 


Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Ser Glu Ala Phe Gln Lys 
                245                 250                 255     


Gly Gly Arg Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly 
            260                 265                 270         


Glu Ser His Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu 
        275                 280                 285             


Arg Asp Asn Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn 
    290                 295                 300                 


Arg Arg Gly Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile 
305                 310                 315                 320 


Ala Ser Asp Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala 
                325                 330                 335     


Ala Leu Lys Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu 
            340                 345                 350         


Glu Gly Thr Asn Lys Asn Glu Thr Ser Phe Gly Leu Glu Met Ser Gln 
        355                 360                 365             


Thr Gly Phe Ser Ser His Val Val Glu Asp Gly Val Leu Leu Gly Ala 
    370                 375                 380                 


Val Gly Ala Tyr Asp Trp Asn Gly Ala Val Leu Lys Glu Thr Ser Ala 
385                 390                 395                 400 


Gly Lys Val Ile Pro Leu Arg Glu Ser Tyr Leu Lys Glu Phe Pro Glu 
                405                 410                 415     


Glu Leu Lys Asn His Gly Ala Tyr Leu Gly Tyr Thr Val Thr Ser Val 
            420                 425                 430         


Val Ser Ser Arg Gln Gly Arg Val Tyr Val Ala Gly Ala Pro Arg Phe 
        435                 440                 445             


Asn His Thr Gly Lys Val Ile Leu Phe Thr Met His Asn Asn Arg Ser 
    450                 455                 460                 


Leu Thr Ile His Gln Ala Met Arg Gly Gln Gln Ile Gly Ser Tyr Phe 
465                 470                 475                 480 


Gly Ser Glu Ile Thr Ser Val Asp Ile Asp Gly Asp Gly Val Thr Asp 
                485                 490                 495     


Val Leu Leu Val Gly Ala Pro Met Tyr Phe Asn Glu Gly Arg Glu Arg 
            500                 505                 510         


Gly Lys Val Tyr Val Tyr Glu Leu Arg Gln Asn Leu Phe Val Tyr Asn 
        515                 520                 525             


Gly Thr Leu Lys Asp Ser His Ser Tyr Gln Asn Ala Arg Phe Gly Ser 
    530                 535                 540                 


Ser Ile Ala Ser Val Arg Asp Leu Asn Gln Asp Ser Tyr Asn Asp Val 
545                 550                 555                 560 


Val Val Gly Ala Pro Leu Glu Asp Asn His Ala Gly Ala Ile Tyr Ile 
                565                 570                 575     


Phe His Gly Phe Arg Gly Ser Ile Leu Lys Thr Pro Lys Gln Arg Ile 
            580                 585                 590         


Thr Ala Ser Glu Leu Ala Thr Gly Leu Gln Tyr Phe Gly Cys Ser Ile 
        595                 600                 605             


His Gly Gln Leu Asp Leu Asn Glu Asp Gly Leu Ile Asp Leu Ala Val 
    610                 615                 620                 


Gly Ala Leu Gly Asn Ala Val Ile Leu Trp Ser Arg Pro Val Val Gln 
625                 630                 635                 640 


Ile Asn Ala Ser Leu His Phe Glu Pro Ser Lys Ile Asn Ile Phe His 
                645                 650                 655     


Arg Asp Cys Lys Arg Ser Gly Arg Asp Ala Thr Cys Leu Ala Ala Phe 
            660                 665                 670         


Leu Cys Phe Thr Pro Ile Phe Leu Ala Pro His Phe Gln Thr Thr Thr 
        675                 680                 685             


Val Gly Ile Arg Tyr Asn Ala Thr Met Asp Glu Arg Arg Tyr Thr Pro 
    690                 695                 700                 


Arg Ala His Leu Asp Glu Gly Gly Asp Arg Phe Thr Asn Arg Ala Val 
705                 710                 715                 720 


Leu Leu Ser Ser Gly Gln Glu Leu Cys Glu Arg Ile Asn Phe His Val 
                725                 730                 735     


Leu Asp Thr Ala Asp Tyr Val Lys Pro Val Thr Phe Ser Val Glu Tyr 
            740                 745                 750         


Ser Leu Glu Asp Pro Asp His Gly Pro Met Leu Asp Asp Gly Trp Pro 
        755                 760                 765             


Thr Thr Leu Arg Val Ser Val Pro Phe Trp Asn Gly Cys Asn Glu Asp 
    770                 775                 780                 


Glu His Cys Val Pro Asp Leu Val Leu Asp Ala Arg Ser Asp Leu Pro 
785                 790                 795                 800 


Thr Ala Met Glu Tyr Cys Gln Arg Val Leu Arg Lys Pro Ala Gln Asp 
                805                 810                 815     


Cys Ser Ala Tyr Thr Leu Ser Phe Asp Thr Thr Val Phe Ile Ile Glu 
            820                 825                 830         


Ser Thr Arg Gln Arg Val Ala Val Glu Ala Thr Leu Glu Asn Arg Gly 
        835                 840                 845             


Glu Asn Ala Tyr Ser Thr Val Leu Asn Ile Ser Gln Ser Ala Asn Leu 
    850                 855                 860                 


Gln Phe Ala Ser Leu Ile Gln Lys Glu Asp Ser Asp Gly Ser Ile Glu 
865                 870                 875                 880 


Cys Val Asn Glu Glu Arg Arg Leu Gln Lys Gln Val Cys Asn Val Ser 
                885                 890                 895     


Tyr Pro Phe Phe Arg Ala Lys Ala Lys Val Ala Phe Arg Leu Asp Phe 
            900                 905                 910         


Glu Phe Ser Lys Ser Ile Phe Leu His His Leu Glu Ile Glu Leu Ala 
        915                 920                 925             


Ala Gly Ser Asp Ser Asn Glu Arg Asp Ser Thr Lys Glu Asp Asn Val 
    930                 935                 940                 


Ala Pro Leu Arg Phe His Leu Lys Tyr Glu Ala Asp Val Leu Phe Thr 
945                 950                 955                 960 


Arg Ser Ser Ser Leu Ser His Tyr Glu Val Lys Pro Asn Ser Ser Leu 
                965                 970                 975     


Glu Arg Tyr Asp Gly Ile Gly Pro Pro Phe Ser Cys Ile Phe Arg Ile 
            980                 985                 990         


Gln Asn Leu Gly Leu Phe Pro Ile  His Gly Met Met Met  Lys Ile Thr 
        995                 1000                 1005             


Ile Pro  Ile Ala Thr Arg Ser  Gly Asn Arg Leu Leu  Lys Leu Arg 
    1010                 1015                 1020             


Asp Phe  Leu Thr Asp Glu Ala  Asn Thr Ser Cys Asn  Ile Trp Gly 
    1025                 1030                 1035             


Asn Ser  Thr Glu Tyr Arg Pro  Thr Pro Val Glu Glu  Asp Leu Arg 
    1040                 1045                 1050             


Arg Ala  Pro Gln Leu Asn His  Ser Asn Ser Asp Val  Val Ser Ile 
    1055                 1060                 1065             


Asn Cys  Asn Ile Arg Leu Val  Pro Asn Gln Glu Ile  Asn Phe His 
    1070                 1075                 1080             


Leu Leu  Gly Asn Leu Trp Leu  Arg Ser Leu Lys Ala  Leu Lys Tyr 
    1085                 1090                 1095             


Lys Ser  Met Lys Ile Met Val  Asn Ala Ala Leu Gln  Arg Gln Phe 
    1100                 1105                 1110             


His Ser  Pro Phe Ile Phe Arg  Glu Glu Asp Pro Ser  Arg Gln Ile 
    1115                 1120                 1125             


Val Phe  Glu Ile Ser Lys Gln  Glu Asp Trp Gln Val  Pro Ile Trp 
    1130                 1135                 1140             


Ile Ile  Val Gly Ser Thr Leu  Gly Gly Leu Leu Leu  Leu Ala Leu 
    1145                 1150                 1155             


Leu Val  Leu Ala Leu Trp Lys  Leu Gly Phe Phe Arg  Ser Ala Arg 
    1160                 1165                 1170             


Arg Arg  Arg Glu Pro Gly Leu  Asp Pro Thr Pro Lys  Val Leu Glu 
    1175                 1180                 1185             


<210>  80
<211>  1048
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Gln Asp 
                165                 170                 175     


Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser Ile Asp 
            180                 185                 190         


Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser Phe Tyr 
        195                 200                 205             


Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys 
    210                 215                 220                 


Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr 
225                 230                 235                 240 


Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val 
                245                 250                 255     


Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly 
            260                 265                 270         


Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly 
        275                 280                 285             


Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala 
    290                 295                 300                 


Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr 
305                 310                 315                 320 


Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp 
                325                 330                 335     


Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala 
            340                 345                 350         


Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala 
        355                 360                 365             


Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly 
    370                 375                 380                 


Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys 
385                 390                 395                 400 


Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val 
                405                 410                 415     


Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro 
            420                 425                 430         


Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly 
        435                 440                 445             


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu 
    450                 455                 460                 


Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr 
465                 470                 475                 480 


Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr 
                485                 490                 495     


Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp 
            500                 505                 510         


Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu 
        515                 520                 525             


Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu 
    530                 535                 540                 


Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly 
545                 550                 555                 560 


Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser 
                565                 570                 575     


Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg 
            580                 585                 590         


Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu 
        595                 600                 605             


Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu 
    610                 615                 620                 


Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val 
625                 630                 635                 640 


Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr 
                645                 650                 655     


Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu 
            660                 665                 670         


Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg 
        675                 680                 685             


Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn 
    690                 695                 700                 


Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly 
705                 710                 715                 720 


Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu 
                725                 730                 735     


Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu 
            740                 745                 750         


Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val 
        755                 760                 765             


Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His Val Phe 
    770                 775                 780                 


Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu 
785                 790                 795                 800 


Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly 
                805                 810                 815     


Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys 
            820                 825                 830         


Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly 
        835                 840                 845             


Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys 
    850                 855                 860                 


Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln 
865                 870                 875                 880 


Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu 
                885                 890                 895     


Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile 
            900                 905                 910         


Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr 
        915                 920                 925             


Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln 
    930                 935                 940                 


Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu 
945                 950                 955                 960 


Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu 
                965                 970                 975     


Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val 
            980                 985                 990         


Pro Val Trp Val Ile Ile Leu Ala  Val Leu Ala Gly Leu  Leu Leu Leu 
        995                 1000                 1005             


Ala Val  Leu Val Phe Val Met  Tyr Arg Met Gly Phe  Phe Lys Arg 
    1010                 1015                 1020             


Val Arg  Pro Pro Gln Glu Glu  Gln Glu Arg Glu Gln  Leu Gln Pro 
    1025                 1030                 1035             


His Glu  Asn Gly Glu Gly Asn  Ser Glu Thr 
    1040                 1045             


<210>  81
<211>  1039
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg Ala Ile Pro Ile Trp Trp Val  Leu Val Gly Val Leu  Gly Gly Leu 
        995                 1000                 1005             


Leu Leu  Leu Thr Ile Leu Val  Leu Ala Met Trp Lys  Val Gly Phe 
    1010                 1015                 1020             


Phe Lys  Arg Asn Arg Pro Pro  Leu Glu Glu Asp Asp  Glu Glu Gly 
    1025                 1030                 1035             


Glu 
    


<210>  82
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp 
            100                 105                 110         


Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu 
        115                 120                 125             


Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg 
    130                 135                 140                 


Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu 
145                 150                 155                 160 


Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu 
                165                 170                 175     


Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln 
            180                 185                 190         


Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe 
        195                 200                 205             


Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val 
    210                 215                 220                 


Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val 
225                 230                 235                 240 


Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr 
                245                 250                 255     


Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn 
            260                 265                 270         


Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys 
        275                 280                 285             


His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser 
    290                 295                 300                 


Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu 
305                 310                 315                 320 


Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly 
                325                 330                 335     


Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser 
            340                 345                 350         


Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val 
        355                 360                 365             


Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu 
    370                 375                 380                 


Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg 
385                 390                 395                 400 


Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys 
                405                 410                 415     


Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg 
            420                 425                 430         


Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val 
        435                 440                 445             


Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu 
    450                 455                 460                 


Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile 
465                 470                 475                 480 


Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile 
                485                 490                 495     


Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly 
            500                 505                 510         


Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu 
        515                 520                 525             


Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro 
    530                 535                 540                 


Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly 
545                 550                 555                 560 


Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser 
                565                 570                 575     


Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu 
            580                 585                 590         


Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile 
        595                 600                 605             


Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe 
    610                 615                 620                 


Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr 
625                 630                 635                 640 


Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile 
                645                 650                 655     


Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr 
            660                 665                 670         


Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe 
        675                 680                 685             


Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser 
    690                 695                 700                 


Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp 
705                 710                 715                 720 


Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu 
                725                 730                 735     


Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro 
            740                 745                 750         


Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser 
    770                 775                 780                 


Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser 
785                 790                 795                 800 


Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp 
                805                 810                 815     


Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val 
            820                 825                 830         


Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu 
        835                 840                 845             


Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser 
    850                 855                 860                 


Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe 
865                 870                 875                 880 


Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala 
                885                 890                 895     


Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser 
            900                 905                 910         


Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln 
        915                 920                 925             


Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro 
    930                 935                 940                 


Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser 
945                 950                 955                 960 


Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro 
                965                 970                 975     


Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met 
            980                 985                 990         


Glu Pro Pro Val Pro Cys His Tyr  Glu Asp Leu Glu Arg  Leu Pro Asp 
        995                 1000                 1005             


Ala Ala  Glu Pro Cys Leu Pro  Gly Ala Leu Phe Arg  Cys Pro Val 
    1010                 1015                 1020             


Val Phe  Arg Gln Glu Ile Leu  Val Gln Val Ile Gly  Thr Leu Glu 
    1025                 1030                 1035             


Leu Val  Gly Glu Ile Glu Ala  Ser Ser Met Phe Ser  Leu Cys Ser 
    1040                 1045                 1050             


Ser Leu  Ser Ile Ser Phe Asn  Ser Ser Lys His Phe  His Leu Tyr 
    1055                 1060                 1065             


Gly Ser  Asn Ala Ser Leu Ala  Gln Val Val Met Lys  Val Asp Val 
    1070                 1075                 1080             


Val Tyr  Glu Lys Gln Met Leu  Tyr Leu Tyr Val Leu  Ser Gly Ile 
    1085                 1090                 1095             


Gly Gly  Leu Leu Leu Leu Leu  Leu Ile Phe Ile Val  Leu Tyr Lys 
    1100                 1105                 1110             


Val Gly  Phe Phe Lys Arg Asn  Leu Lys Glu Lys Met  Glu Ala Gly 
    1115                 1120                 1125             


Arg Gly  Val Pro Asn Gly Ile  Pro Ala Glu Asp Ser  Glu Gln Leu 
    1130                 1135                 1140             


Ala Ser  Gly Gln Glu Ala Gly  Asp Pro Gly Cys Leu  Lys Pro Leu 
    1145                 1150                 1155             


His Glu  Lys Asp Ser Glu Ser  Gly Gly Gly Lys Asp  
    1160                 1165                 1170 


<210>  83
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu 
            500                 505                 510         


Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly His 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met 
    610                 615                 620                 


Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp 
625                 630                 635                 640 


Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu His 
                645                 650                 655     


Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser 
            660                 665                 670         


Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg 
        675                 680                 685             


Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val 
    690                 695                 700                 


Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn 
705                 710                 715                 720 


Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser 
                725                 730                 735     


Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu 
            740                 745                 750         


Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys 
        755                 760                 765             


Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe 
    770                 775                 780                 


Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe 
785                 790                 795                 800 


Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr 
                805                 810                 815     


Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser 
            820                 825                 830         


Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu 
        835                 840                 845             


Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys 
    850                 855                 860                 


Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn 
865                 870                 875                 880 


Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu 
                885                 890                 895     


Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys 
            900                 905                 910         


Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val 
        915                 920                 925             


Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser 
    930                 935                 940                 


Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg 
                965                 970                 975     


Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu 
            980                 985                 990         


Asn Leu Ser Ser Thr Cys His Thr  Lys Glu Arg Leu Pro  Ser His Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala Glu Leu Arg  Lys Ala Pro Val Val  Asn Cys Ser 
    1010                 1015                 1020             


Ile Ala  Val Cys Gln Arg Ile  Gln Cys Asp Ile Pro  Phe Phe Gly 
    1025                 1030                 1035             


Ile Gln  Glu Glu Phe Asn Ala  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Asp Trp  Tyr Ile Lys Thr Ser  His Asn His Leu Leu  Ile Val Ser 
    1055                 1060                 1065             


Thr Ala  Glu Ile Leu Phe Asn  Asp Ser Val Phe Thr  Leu Leu Pro 
    1070                 1075                 1080             


Gly Gln  Gly Ala Phe Val Arg  Ser Gln Thr Glu Thr  Lys Val Glu 
    1085                 1090                 1095             


Pro Phe  Glu Val Pro Asn Pro  Leu Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Val Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Ala Leu Tyr 
    1115                 1120                 1125             


Lys Leu  Gly Phe Phe Lys Arg  Gln Tyr Lys Asp Met  Met Ser Glu 
    1130                 1135                 1140             


Gly Gly  Pro Pro Gly Ala Glu  Pro Gln 
    1145                 1150         


<210>  84
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


