                         SEQUENCE LISTING

<110>  CELLDEX THERAPEUTICS, INC.
 
<120>  Anti-Axl Antibodies and Uses Thereof

<130>  12638-156-228

<140>  PCT/US2020/025368 
<141>  2020-03-27

<150>  US 62/826,909
<151>  2019-03-29 

<160>  135   

<170>  PatentIn version 3.5

<210>  1
<211>  104
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Axl extracelullar domain 1 (Ig-like domain 1)

<400>  1

Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly 
1               5                   10                  15      


Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro Pro 
            20                  25                  30          


Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser 
        35                  40                  45              


Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile 
    50                  55                  60                  


Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly 
65                  70                  75                  80  


Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser Gln 
                85                  90                  95      


Pro Gly Tyr Val Gly Leu Glu Gly 
            100                 


<210>  2
<211>  90
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Axl extracelullar domain 2 (Ig-like domain 2)

<400>  2

Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala Ala Asn 
1               5                   10                  15      


Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu Pro Val 
            20                  25                  30          


Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala Pro Gly 
        35                  40                  45              


His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys Thr Ser 
    50                  55                  60                  


Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr Ser Arg 
65                  70                  75                  80  


Thr Ala Thr Ile Thr Val Leu Pro Gln Gln 
                85                  90  


<210>  3
<211>  104
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Axl extracelullar domain 3 (Fnlll-like domain 1)

<400>  3

Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val 
1               5                   10                  15      


Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr 
            20                  25                  30          


Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln Ala Gly Glu 
        35                  40                  45              


Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser Val Pro Pro 
    50                  55                  60                  


His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro Tyr His Ile 
65                  70                  75                  80  


Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr His Trp 
                85                  90                  95      


Leu Pro Val Glu Thr Pro Glu Gly 
            100                 


<210>  4
<211>  111
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Axl extracelullar domain 4 (Fnlll-like domain 2)

<400>  4

Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser 
1               5                   10                  15      


Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr 
            20                  25                  30          


Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val 
        35                  40                  45              


Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly 
    50                  55                  60                  


Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala 
65                  70                  75                  80  


Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg 
                85                  90                  95      


Pro Gly Gln Ala Gln Pro Val His Gln Leu Val Lys Glu Pro Ser 
            100                 105                 110     


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon heavy chain variable region


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Leu or Val)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Lys or Gln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Gly or Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is an amino acid with a positively charged 
side chain (for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is Ala or Thr

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Ala or Gly)

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa is Asp, Asn or Glu

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa is an amino acid with a polar side chain 
(for example, Asn or Ser)

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa is Thr, Ser or Ile

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa is an amino acid with an aliphatic or hydrophobic 
side chain (for example, Leu or Ala)

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa is an amino acid with a positively charged 
side chain (for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa is Thr or Ala 

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa is Leu or Thr

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Ser or Ala

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Xaa Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Ser Lys Xaa Xaa 
65                  70                  75                  80  


Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Leu Arg Leu Phe Ala Tyr Trp Gly Gln Gly Thr Xaa 
            100                 105                 110         


Val Thr Val Ser Xaa 
        115         


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon light chain variable region

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Lys Ser Leu Leu His Arg 
            20                  25                  30          


Gln Gly Ile Thr Tyr Val Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Val 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Met Ser Thr Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gly Gln Leu 
                85                  90                  95      


Leu Glu Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 heavy chain variable region 

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Leu Arg Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 heavy chain variable region

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Leu Arg Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 heavy chain variable region

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Leu Arg Leu Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 heavy chain variable region

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Leu Arg Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  mouse

<220>
<223>  Ab301 heavy chain variable region

<400>  11

Glu Val Lys Leu Glu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Met 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Ile Arg Ser Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Leu Arg Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  12
<211>  112
<212>  PRT
<213>  mouse

<220>
<223>  Ab301 light chain variable region

<400>  12

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Ile Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Pro Ser Met Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 
            20                  25                  30          


Asn Gly Ile Thr Tyr Val Tyr Trp Tyr Leu Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Thr Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Lys Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Gly Gln Leu 
                85                  90                  95      


Leu Glu Asn Pro Tyr Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab302 heavy chain variable region

<400>  13
gaggtgcagc tggtggaatc cggcggaggt ttagtgaagc ccggtggctc tttaaagctg       60

agctgtgccg cctccggctt caccttctcc gactactgga tggagtgggt gcggcaagct      120

cccggtaagg gtttagagtg ggtggccgag atccggaaca aggtgaacaa ctacgccacc      180

tactacggca agtccgtgaa gggccggttc accatctccc gggacgactc caagaacact      240

ttatatttac agatgaactc tttaaagacc gaggacaccg ccgtgtatta ctgcaacact      300

ttacggctgt ttgcctactg gggccaaggt actttagtga cagtgtcctc c               351


<210>  14
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305 light chain variable region

<400>  14
gacatccaga tgacacagag cccttcctct ttatccgctt ccgtgggaga tcgtgtgacc       60

atcacttgtc gttcctccaa gtctttactg cataggcaag gtatcaccta cgtgtactgg      120

taccagcaga agcccggcaa ggtgcccaag ctgctgatct atcgtatgtc cactttagct      180

tccggcgtgc cttctcgttt ttctggctcc ggctctggca cagacttcac tttaaccatc      240

tcctctttac agcccgagga cgtggccaca tactactgcg gccagctgct ggagaatccc      300

tacaccttcg gccaaggtac caagctggag atcaag                                336


<210>  15
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab303 heavy chain variable region

<400>  15
gaggtgcagc tggtggagtc cggaggaggc gtggtgcaac ccggtcgttc tttaaggctg       60

tcttgtgctg cttccggctt caccttctcc gactactgga tggagtgggt gaggcaagct      120

cccggtaaag gactggagtg ggtggccgag atccggaaca aggtgaacaa ctacgccacc      180

tactacggca agagcgtgaa gggtcgtttc accatctctc gtgacaactc caagaacact      240

ttatatttac agatgaactc cttacgtgcc gaggacaccg ccgtgtacta ctgcaacact      300

ttacggctgt tcgcttactg gggacaaggt actttagtga ccgtgtcctc c               351


<210>  16
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab304 heavy chain variable region

<400>  16
gaggtgcagc tggtggagtc cggaggcgga ctggtgcaac ccggtggatc tctgaggctg       60

tcttgtgccg cttccggctt caccttctcc gactactgga tggagtgggt gaggcaagct      120

cccggcaaag gactggagtg ggtcggcgag atccggaaca aggtgaacaa ctacgccacc      180

tactacggca agtccgtgaa gggtcgtttc accatctctc gtgacgagag caagaactct      240

ttatatttac agatgaactc tttaaagacc gaggacaccg ccgtgtacta ctgcaacact      300

ttacgtctgt tcgcctattg gggccaaggt accacagtga ccgtgtcctc c               351


<210>  17
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab305 heavy chain variable region

<400>  17
gaggtgcagc tggtggaatc cggcggagga ctggtgcagc ccggtcgttc tttaaggctg       60

tcttgtacag cctccggctt caccttcagc gactactgga tggagtgggt gaggcaagct      120

cccggtaagg gactggagtg ggtgggcgag atccggaaca aggtgaacaa ctacgccacc      180

tactacggca agagcgtgaa gggtcgtttc accatctctc gtgacgattc caagtccatc      240

gcctatttac agatgaactc tttaaagacc gaggacaccg ccgtgtacta ctgcaacact      300

ttacggctgt tcgcctattg gggccaaggt actttagtga ccgtgtccgc c               351


<210>  18
<211>  351
<212>  DNA
<213>  mouse

<220>
<223>  Ab301 heavy chain variable region

<400>  18
gaggtgaagc tggaagcctc cggcggagga ctggtgcagc ccggtatgag cgtgaagctg       60

agctgcacca ccagcggctt caccttcagc gactactgga tggagtgggt gaggcaagct      120

cccggtaaag gtttagagtg ggtggccgaa attcgtaaca aggtgaacaa ctacgccacc      180

tactacggca agtccgtgaa gggtcgtttt accatctctc gtgacgacag caagagcatc      240

gtgtatttac agatgaacag cattcgtagc gaggacaccg gcatctacta ctgcaacact      300

ttaaggctgt tcgcctactg gggacaaggt actttagtga ccgtgtccgc c               351


<210>  19
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab301 light chain variable region

<400>  19
gacattgtga tgacccaagc tcctttatcc atcagcgtga cacccggtga gagccccagc       60

atgagctgtc gtagcagcaa gtctttactg catcgtaacg gcatcaccta cgtgtactgg      120

tatttacaga agcccggcaa gagcccccag ctgctgatct atcgtatgag cacactggcc      180

agcggcgtgc ccgatagatt ctccggcagc ggcagcgaga ccgacttcac tttaaagatc      240

aacaaggtgg aggccgagga cgtgggcatc tactactgcg gccagctgct ggagaatccc      300

tacaccttcg gcgccggcac aaggctggag atcaag                                336


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR1 (Kabat)

<400>  20

Asp Tyr Trp Met Glu 
1               5   


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR2 (Kabat)

<400>  21

Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr Tyr Gly Lys Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR3 (Kabat, Chothia and AbM)

<400>  22

Leu Arg Leu Phe Ala Tyr 
1               5       


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR1 (Chothia)

<400>  23

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR2 (Chothia)

<400>  24

Arg Asn Lys Val Asn Asn Tyr Ala 
1               5               


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR1 (AbM)

<400>  25

Gly Phe Thr Phe Ser Asp Tyr Trp Met Glu 
1               5                   10  


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR2 (AbM)

<400>  26

Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr 
1               5                   10          


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR1 (Contact)

<400>  27

Ser Asp Tyr Trp Met Glu 
1               5       


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH CDR2 (Contact)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Ala or Gly)

<400>  28

Trp Val Xaa Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr 
1               5                   10                  15  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VH CDR3 (Contact)

<400>  29

Asn Thr Leu Arg Leu Phe Ala 
1               5           


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL CDR1 (Kabat, Chothia and AbM)

<400>  30

Arg Ser Ser Lys Ser Leu Leu His Arg Gln Gly Ile Thr Tyr Val Tyr 
1               5                   10                  15      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VL CDR2 (Kabat, Chothia and AbM)
<400>  31

Arg Met Ser Thr Leu Ala Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VL CDR3 (Kabat, Chothia, AbM, IMGT)

<400>  32

Gly Gln Leu Leu Glu Asn Pro Tyr Thr 
1               5                   


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL CDR1 (Contact)

<400>  33

Leu His Arg Gln Gly Ile Thr Tyr Val Tyr Trp Tyr 
1               5                   10          


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VL CDR2 (Contact)

<400>  34

Leu Leu Ile Tyr Arg Met Ser Thr Leu Ala 
1               5                   10  


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303/304/305/Abcon VL CDR3 (Contact)

<400>  35

Gly Gln Leu Leu Glu Asn Pro Tyr 
1               5               


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/Ab302/303 VH CDR2 (Contact)

<400>  36

Trp Val Ala Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304/305 VH CDR2 (Contact)

<400>  37

Trp Val Gly Glu Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr Tyr 
1               5                   10                  15  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL CDR1 (Kabat, Chothia, AbM)

<400>  38

Arg Ser Ser Lys Ser Leu Leu His Arg Asn Gly Ile Thr Tyr Val Tyr 
1               5                   10                  15      


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL CDR1 (Contact)

<400>  39

Leu His Arg Asn Gly Ile Thr Tyr Val Tyr Trp Tyr 
1               5                   10          


<210>  40
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR1 (Kabat)


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Leu or Val)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Lys or Gln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Gly or Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is an amino acid with a positively charged side chain 
(for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is Ala or Thr

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR2 (Kabat and AbM)


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Ala or Gly)

<400>  41

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Xaa 
1               5                   10                  


<210>  42
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR3 (Kabat)


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Asp, Asn or Glu

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is an amino acid with a polar side chain 
(for example, Asn or Ser)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Thr, Ser or Ile

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is an amino acid with an aliphatic or hydrophobic side chain 
(for example, Leu or Ala)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is an amino acid with a positively charged side chain 
(for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Thr or Ala

<400>  42

Arg Phe Thr Ile Ser Arg Asp Xaa Ser Lys Xaa Xaa Xaa Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
            20                  25                  30          


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR4 (Kabat, Chothia, AbM, IMGT)


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Leu or Thr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Ser or Ala

<400>  43

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Xaa 
1               5                   10      


<210>  44
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR1 (Chothia, AbM, IMGT)


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is an amino acid with an aliphatic side chain
 (for example, Leu or Val)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Lys or Gln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Gly or Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is an amino acid with a positively charged side chain 
(for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is Ala or Thr

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Ala Ser 
            20                  25  


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR2 (Chothia)


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Ala or Gly)

<400>  45

Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Xaa Glu Ile 
            


<210>  46
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR3 (Chothia)


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa is Asp, Asn or Glu

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is an amino acid with a polar side chain 
(for example, Asn or Ser)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is Thr, Ser or Ile

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa  is an amino acid with an aliphatic or hydrophobic side 
chain (for example, Leu or Ala)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is an amino acid with a positively charged 
side chain (for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is Thr or Ala

<400>  46

Thr Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Xaa Ser Lys Xaa Xaa Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
        35                  40      


<210>  47
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR3 (AbM)


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is Asp, Asn or Glu

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is an amino acid with a polar side chain 
(for example, Asn or Ser)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Thr, Ser or Ile

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa  is an amino acid with an aliphatic or hydrophobic side 
chain (for example, Leu or Ala)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is an amino acid with a positively charged 
side chain (for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is Thr or Ala

<400>  47

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Ser 
1               5                   10                  15      


Lys Xaa Xaa Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Asn Thr 
        35                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR1 (Contact)


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is an amino acid with an aliphatic side chain 
(for example, Leu or Val)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Lys or Gln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Gly or Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is an amino acid with a positively charged side chain 
(for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is Ala or Thr

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303/304/305/Abcon VH FR2 (Contact)

<400>  49

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
1               5                   10      


<210>  50
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR3 (Contact)


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is Asp, Asn or Glu

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is an amino acid with a polar side chain 
(for example, Asn or Ser)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Thr, Ser or Ile

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa  is an amino acid with an aliphatic or hydrophobic side 
chain (for example, Leu or Ala)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is an amino acid with a positively charged 
side chain (for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is Thr or Ala

<400>  50

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Ser 
1               5                   10                  15      


Lys Xaa Xaa Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR4 (Contact)


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Leu or Thr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Ser or Ala

<400>  51

Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Xaa 
1               5                   10          


<210>  52
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR1 (Kabat, Chothia, AbM)

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR2 (Kabat, Chothia, AbM)

<400>  53

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  54
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR3 (Kabat, Chothia, AbM)

<400>  54

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR4 (Kabat, Chothia, AbM)

<400>  55

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR1 (Contact)

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Lys Ser Leu 
            20                  25                  


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR2 (Contact)

<400>  57

Gln Gln Lys Pro Gly Lys Val Pro Lys 
1               5                   


<210>  58
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR3 (Contact)

<400>  58

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr 
            20                  25                  30          


Cys 
    


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR4 (Contact)

<400>  59

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10      


<210>  60
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR1 (Kabat)

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303 VH FR2 (Kabat)

<400>  61

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  62
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR3 (Kabat)

<400>  62

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
            20                  25                  30          


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303 VH FR4 (Kabat, Chothia, AbM, IMGT)

<400>  63

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  64
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR1 (Chothia, AbM, IMGT)

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  65
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303 VH FR2 (Chothia)

<400>  65

Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Glu Ile 
            


<210>  66
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR3 (Chothia)

<400>  66

Thr Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
        35                  40      


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303 VH FR2 (AbM)

<400>  67

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  68
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR3 (AbM)

<400>  68

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Asn Thr 
        35                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR1 (Contact)

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  70
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR3 (Contact)

<400>  70

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  71
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR1 (Kabat)

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  72
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR3 (Kabat)

<400>  72

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
            20                  25                  30          


<210>  73
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR1 (Chothia, AbM, IMGT)

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  74
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR3 (Chothia)

<400>  74

Thr Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
        35                  40      


<210>  75
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR3 (AbM)

<400>  75

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Asn Thr 
        35                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR1 (Contact)

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  77
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR3 (Contact)

<400>  77

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303 VH FR4 (Contact)

<400>  78

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  79
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR1 (Kabat)

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304/305 VH FR2 (Kabat)

<400>  80

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  81
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR3 (Kabat)

<400>  81

Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
            20                  25                  30          


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR4 (Kabat, Chothia, AbM INGT)

<400>  82

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR1 (Chothia, AbM INGT)

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR2 (Chothia)

<400>  84

Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Gly Glu Ile 
            


<210>  85
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR3 (Chothia)

<400>  85

Thr Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Glu Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
        35                  40      


<210>  86
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304/305 VH FR2 (AbM)

<400>  86

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  87
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR3 (AbM)

<400>  87

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Asn Thr 
        35                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR1 (Contact)

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  89
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR3 (Contact)

<400>  89

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR4 (Contact)

<400>  90

Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10          


<210>  91
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR1 (Kabat)

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  92
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR3 (Kabat)

<400>  92

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
            20                  25                  30          


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/305 VH FR4 (Kabat, Chothia, AbM, IMGT)

<400>  93

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  94
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR1 (Chothia, AbM, INGT)

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  95
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR3 (Chothia)

<400>  95

Thr Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
        35                  40      


<210>  96
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR3 (AbM)

<400>  96

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
1               5                   10                  15      


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Asn Thr 
        35                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR1 (Contact)

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  98
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR3 (Contact)

<400>  98

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
1               5                   10                  15      


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/305 VH FR4 (Contact)

<400>  99

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10          


<210>  100
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR1 (Kabat)

<400>  100

Glu Val Lys Leu Glu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Met 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  101
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR3 (Kabat)

<400>  101

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Ile Arg Ser Glu Asp Thr Gly Ile Tyr Tyr Cys Asn Thr 
            20                  25                  30          


<210>  102
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR1 (Chothia, AbM, IMGT)

<400>  102

Glu Val Lys Leu Glu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Met 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser 
            20                  25  


<210>  103
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR3 (Chothia)

<400>  103

Thr Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Ser Ile Val Tyr Leu Gln Met Asn Ser Ile Arg Ser Glu 
            20                  25                  30          


Asp Thr Gly Ile Tyr Tyr Cys Asn Thr 
        35                  40      


<210>  104
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR3 (AbM)

<400>  104

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
1               5                   10                  15      


Lys Ser Ile Val Tyr Leu Gln Met Asn Ser Ile Arg Ser Glu Asp Thr 
            20                  25                  30          


Gly Ile Tyr Tyr Cys Asn Thr 
        35                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR1 (Contact)

<400>  105

Glu Val Lys Leu Glu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Met 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe 
            20                  25                  


<210>  106
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR3 (Contact)

<400>  106

Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
1               5                   10                  15      


Lys Ser Ile Val Tyr Leu Gln Met Asn Ser Ile Arg Ser Glu Asp Thr 
            20                  25                  30          


Gly Ile Tyr Tyr Cys 
        35          


<210>  107
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR1 (Kabat, Chothia, AbM)

<400>  107

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Ile Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Pro Ser Met Ser Cys 
            20              


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR2 (Kabat, Chothia, AbM)

<400>  108

Trp Tyr Leu Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  109
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR3 (Kabat, Chothia, AbM)

<400>  109

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Asn Lys Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR4 (Kabat, Chothia, AbM, IMGT)

<400>  110

Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR1 (Contact)

<400>  111

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Ile Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Pro Ser Met Ser Cys Arg Ser Ser Lys Ser Leu 
            20                  25                  


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR2 (Contact)

<400>  112

Leu Gln Lys Pro Gly Lys Ser Pro Gln 
1               5                   


<210>  113
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR3 (Contact)

<400>  113

Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe 
1               5                   10                  15      


Thr Leu Lys Ile Asn Lys Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr 
            20                  25                  30          


Cys 
    


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR4 (Contact)

<400>  114

Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
1               5                   10      


<210>  115
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab305 VH FR3 (IMGT)

<400>  115

Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  116
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VH FR3 (IMGT)

<400>  116

Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Lys Ser Ile Val Tyr Leu Gln Met Asn Ser Ile Arg Ser Glu Asp 
            20                  25                  30          


Thr Gly Ile Tyr Tyr Cys 
        35              


<210>  117
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR1 (IMGT)

<400>  117

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Ile Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Pro Ser Met Ser Cys Arg Ser Ser 
            20                  25      


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR2 (IMGT)

<400>  118

Val Tyr Trp Tyr Leu Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  119
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL FR3 (IMGT)

<400>  119

Thr Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Asn Lys Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303/304/305/Abcon VH CDR1 (IMGT)

<400>  120

Gly Phe Thr Phe Ser Asp Tyr Trp 
1               5               


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303/304/305/Abcon VH CDR2 (IMGT)

<400>  121

Ile Arg Asn Lys Val Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303/304/305/Abcon VH CDR3 (IMGT)

<400>  122

Asn Thr Leu Arg Leu Phe Ala Tyr 
1               5               


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL CDR1 (IMGT)

<400>  123

Lys Ser Leu Leu His Arg Gln Gly Ile Thr Tyr 
1               5                   10      


<210>  124
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303/304/305/Abcon VL CDR2 (IMGT)

<400>  124

Arg Met Ser 
1           


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR2 (IMGT)


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is an amino acid with an aliphatic side chain
 (for example, Ala or Gly)

<400>  125

Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Xaa 
1               5                   10                  15      


Glu 
    


<210>  126
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abcon VH FR3 (IMGT)


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Asp, Asn or Glu

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is an amino acid with a polar side chain 
(for example, Asn or Ser)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is Thr, Ser or Ile

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is an amino acid with an aliphatic or hydrophobic side 
chain (for example, Leu or Ala)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is an amino acid with a positively charged 
side chain (for example, Lys or Arg)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is Thr or Ala

<400>  126

Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa 
1               5                   10                  15      


Ser Lys Xaa Xaa Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  127
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR1 (IMGT)

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser 
            20                  25      


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR2 (IMGT)

<400>  128

Val Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  129
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302/303/304/305/Abcon VL FR3 (IMGT)

<400>  129

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301 VL CDR1 (IMGT)

<400>  130

Lys Ser Leu Leu His Arg Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab301/302/303 VH FR2 (IMGT)

<400>  131

Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Glu 
    


<210>  132
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab302 VH FR3 (IMGT)

<400>  132

Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  133
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab303 VH FR3 (IMGT)

<400>  133

Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304/305 VH FR2 (IMGT)

<400>  134

Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  15      


Glu 
    


<210>  135
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab304 VH FR3 (IMGT)

<400>  135

Tyr Tyr Gly Lys Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu 
1               5                   10                  15      


Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


