                         SEQUENCE LISTING

<110>  SORRENTO THERAPEUTICS, INC.
 
<120>  ENGINEERED VARIANT ANTIBODIES THAT BIND CD38

<130>  01223-0014-00PCT

<150>  US 62/825,983
<151>  2019-03-29

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 parental heavy chain, 3E10

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Trp Gly Gly Glu Phe Thr Asp Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 parental light chain, 3G3, 3E11, 3H10

<400>  2

Gln Ala Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Ser Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1, 3H10m1g

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Trp Ser Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1, 3G8m1, 3D3m1, 3E10

<400>  4

Gln Ala Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Ser Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Phe His 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Trp Gly Gly Glu Phe Thr Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  6
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Trp Gly Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Trp Ser Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8

<400>  8
000

<210>  9
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Trp Gly Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Trp Ser Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Trp Gly Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N, 3H10NS , 3H10m1g

<400>  12

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Ser Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Phe His 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Ser Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Trp Gly Gly Glu Phe Thr Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  14
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD38 IgG1: heavy chain constant region

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD38 IgG1-SPPC: heavy chain constant region

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  16
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD38 IgG4: heavy chain constant region

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD38: lambda light chain constant region

<400>  17

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CD38: kappa light chain constant region

<400>  18

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  19
<211>  300
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD38 antigen - human

<400>  19

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  20
<211>  300
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<223>  CD38 antigen - cynomolgus monkey

<400>  20

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Val Cys Leu Gly Val Cys Leu Leu Val 
            20                  25                  30          


Leu Leu Ile Leu Val Val Val Val Ala Val Val Leu Pro Arg Trp Arg 
        35                  40                  45              


Gln Gln Trp Ser Gly Ser Gly Thr Thr Ser Arg Phe Pro Glu Thr Val 
    50                  55                  60                  


Leu Ala Arg Cys Val Lys Tyr Thr Glu Val His Pro Glu Met Arg His 
65                  70                  75                  80  


Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser 
                85                  90                  95      


Lys Tyr Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Val Lys 
            100                 105                 110         


Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Thr Leu Leu Trp Ser Arg 
        115                 120                 125             


Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe 
    130                 135                 140                 


Thr Leu Glu Asp Met Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp 
145                 150                 155                 160 


Cys Gly Glu Phe Asn Thr Phe Glu Ile Asn Tyr Gln Ser Cys Pro Asp 
                165                 170                 175     


Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr 
            180                 185                 190         


Val Ser Arg Arg Phe Ala Glu Thr Ala Cys Gly Val Val His Val Met 
        195                 200                 205             


Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly 
    210                 215                 220                 


Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Ala Leu Glu 
225                 230                 235                 240 


Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln 
                245                 250                 255     


Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile 
            260                 265                 270         


Arg Phe Phe Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys 
        275                 280                 285             


Val Lys Asn Pro Glu Asp Ser Ser Cys Leu Ser Gly 
    290                 295                 300 


<210>  21
<211>  304
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  CD38 antigen - mouse

<400>  21

Met Ala Asn Tyr Glu Phe Ser Gln Val Ser Gly Asp Arg Pro Gly Cys 
1               5                   10                  15      


Arg Leu Ser Arg Lys Ala Gln Ile Gly Leu Gly Val Gly Leu Leu Val 
            20                  25                  30          


Leu Ile Ala Leu Val Val Gly Ile Val Val Ile Leu Leu Arg Pro Arg 
        35                  40                  45              


Ser Leu Leu Val Trp Thr Gly Glu Pro Thr Thr Lys His Phe Ser Asp 
    50                  55                  60                  


Ile Phe Leu Gly Arg Cys Leu Ile Tyr Thr Gln Ile Leu Arg Pro Glu 
65                  70                  75                  80  


Met Arg Asp Gln Asn Cys Gln Glu Ile Leu Ser Thr Phe Lys Gly Ala 
                85                  90                  95      


Phe Val Ser Lys Asn Pro Cys Asn Ile Thr Arg Glu Asp Tyr Ala Pro 
            100                 105                 110         


Leu Val Lys Leu Val Thr Gln Thr Ile Pro Cys Asn Lys Thr Leu Phe 
        115                 120                 125             


Trp Ser Lys Ser Lys His Leu Ala His Gln Tyr Thr Trp Ile Gln Gly 
    130                 135                 140                 


Lys Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Ile Ala Asp Asp 
145                 150                 155                 160 


Leu Arg Trp Cys Gly Asp Pro Ser Thr Ser Asp Met Asn Tyr Val Ser 
                165                 170                 175     


Cys Pro His Trp Ser Glu Asn Cys Pro Asn Asn Pro Ile Thr Val Phe 
            180                 185                 190         


Trp Lys Val Ile Ser Gln Lys Phe Ala Glu Asp Ala Cys Gly Val Val 
        195                 200                 205             


Gln Val Met Leu Asn Gly Ser Leu Arg Glu Pro Phe Tyr Lys Asn Ser 
    210                 215                 220                 


Thr Phe Gly Ser Val Glu Val Phe Ser Leu Asp Pro Asn Lys Val His 
225                 230                 235                 240 


Lys Leu Gln Ala Trp Val Met His Asp Ile Glu Gly Ala Ser Ser Asn 
                245                 250                 255     


Ala Cys Ser Ser Ser Ser Leu Asn Glu Leu Lys Met Ile Val Gln Lys 
            260                 265                 270         


Arg Asn Met Ile Phe Ala Cys Val Asp Asn Tyr Arg Pro Ala Arg Phe 
        275                 280                 285             


Leu Gln Cys Val Lys Asn Pro Glu His Pro Ser Cys Arg Leu Asn Thr 
    290                 295                 300                 


<210>  22
<211>  303
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<223>  CD38 antigen - rat

<400>  22

Met Ala Asn Tyr Glu Phe Ser Gln Val Ser Glu Asp Arg Pro Gly Cys 
1               5                   10                  15      


Arg Leu Thr Arg Lys Ala Gln Ile Gly Leu Gly Val Gly Leu Leu Leu 
            20                  25                  30          


Leu Val Ala Leu Val Val Val Val Val Ile Val Leu Trp Pro Arg Ser 
        35                  40                  45              


Pro Leu Val Trp Lys Gly Lys Pro Thr Thr Lys His Phe Ala Asp Ile 
    50                  55                  60                  


Ile Leu Gly Arg Cys Leu Ile Tyr Thr Gln Ile Leu Arg Pro Glu Met 
65                  70                  75                  80  


Arg Asp Gln Asp Cys Lys Lys Ile Leu Ser Thr Phe Lys Arg Gly Phe 
                85                  90                  95      


Ile Ser Lys Asn Pro Cys Asn Ile Thr Asn Glu Asp Tyr Ala Pro Leu 
            100                 105                 110         


Val Lys Leu Val Thr Gln Thr Ile Pro Cys Asn Lys Thr Leu Phe Trp 
        115                 120                 125             


Ser Lys Ser Lys His Leu Ala His Gln Tyr Thr Trp Ile Gln Gly Lys 
    130                 135                 140                 


Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Ile Ala Asp Asp Leu 
145                 150                 155                 160 


Arg Trp Cys Gly Asp Pro Ser Thr Ser Asp Met Asn Tyr Asp Ser Cys 
                165                 170                 175     


Pro His Trp Ser Glu Asn Cys Pro Asn Asn Pro Val Ala Val Phe Trp 
            180                 185                 190         


Asn Val Ile Ser Gln Lys Phe Ala Glu Asp Ala Cys Gly Val Val Gln 
        195                 200                 205             


Val Met Leu Asn Gly Ser Leu Ser Glu Pro Phe Tyr Arg Asn Ser Thr 
    210                 215                 220                 


Phe Gly Ser Val Glu Val Phe Asn Leu Asp Pro Asn Lys Val His Lys 
225                 230                 235                 240 


Leu Gln Ala Trp Val Met His Asp Ile Lys Gly Thr Ser Ser Asn Ala 
                245                 250                 255     


Cys Ser Ser Pro Ser Ile Asn Glu Leu Lys Ser Ile Val Asn Lys Arg 
            260                 265                 270         


Asn Met Ile Phe Ala Cys Gln Asp Asn Tyr Arg Pro Val Arg Phe Leu 
        275                 280                 285             


Gln Cys Val Lys Asn Pro Glu His Pro Ser Cys Arg Leu Asn Val 
    290                 295                 300             


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 (VH  CDR1)

<400>  23

Asp Asp Tyr Met Ser 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 (VH  CDR2)

<400>  24

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 (VH  CDR3)

<400>  25

Glu Asp Trp Gly Gly Glu Phe Thr Asp 
1               5                   


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 (VL  CDR1)

<400>  26

Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Phe Val Tyr 
1               5                   10              


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 (VL  CDR2)

<400>  27

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A2 (VL  CDR3)

<400>  28

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1 (VH  CDR1)

<400>  29

Asp Asp Tyr Met Ser 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1 (VH  CDR2)

<400>  30

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1 (VH  CDR3)

<400>  31

Glu Gly Trp Ser Gly Glu Phe Thr Asp 
1               5                   


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1 (VL  CDR1)

<400>  32

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1 (VL  CDR2)

<400>  33

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1 (VL  CDR3)

<400>  34

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1 (VH  CDR1)

<400>  35

Asp Asp Tyr Met Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1 (VH  CDR2)

<400>  36

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1 (VH  CDR3)

<400>  37

Glu Ala Trp Gly Gly Glu Phe Thr Asn 
1               5                   


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1 (VL  CDR1)

<400>  38

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1 (VL  CDR2)

<400>  39

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G8m1 (VL  CDR3)

<400>  40

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1 (VH  CDR1)

<400>  41

Asp Asp Tyr Met Ser 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1 (VH  CDR2)

<400>  42

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1 (VH  CDR3)

<400>  43

Glu Ala Trp Gly Gly Glu Phe Thr Asp 
1               5                   


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1 (VL  CDR1)

<400>  44

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1 (VL  CDR2)

<400>  45

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E3m1 (VL  CDR3)

<400>  46

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3 (VH  CDR1)

<400>  47

Asp Asp Tyr Met Ser 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3 (VH  CDR2)

<400>  48

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3 (VH  CDR3)

<400>  49

Glu Ala Trp Ser Gly Glu Phe Thr Asp 
1               5                   


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3 (VL  CDR1)

<400>  50

Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Phe Val Tyr 
1               5                   10              


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3 (VL  CDR2)

<400>  51

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3G3 (VL  CDR3)

<400>  52

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11(VH  CDR1)

<400>  53

Asp Asp Tyr Met Ser 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11(VH  CDR2)

<400>  54

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11(VH  CDR3)

<400>  55

Glu Gly Trp Gly Gly Glu Phe Thr Asp 
1               5                   


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11(VL  CDR1)

<400>  56

Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Phe Val Tyr 
1               5                   10              


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11(VL  CDR2)

<400>  57

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E11(VL  CDR3)

<400>  58

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10 (VH  CDR1)

<400>  59

Asp Asp Tyr Met Ser 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10 (VH  CDR2)

<400>  60

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10 (VH  CDR3)

<400>  61

Glu Gly Trp Ser Gly Glu Phe Thr Asp 
1               5                   


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10 (VL  CDR1)

<400>  62

Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Phe Val Tyr 
1               5                   10              


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10 (VL  CDR2)

<400>  63

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10 (VL  CDR3)

<400>  64

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N (VH  CDR1)

<400>  65

Asp Asp Tyr Met Ser 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N (VH  CDR2)

<400>  66

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N (VH  CDR3)

<400>  67

Glu Asp Trp Gly Gly Glu Phe Thr Asp 
1               5                   


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N (VL  CDR1)

<400>  68

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N (VL  CDR2)

<400>  69

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10N (VL  CDR3)

<400>  70

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS (VH  CDR1)

<400>  71

Asp Asp Tyr Met Ser 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS (VH  CDR2)

<400>  72

Ser Val Ser Ser Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS (VH  CDR3)

<400>  73

Glu Asp Trp Gly Gly Glu Phe Thr Asp 
1               5                   


<210>  74
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS (VL  CDR1)

<400>  74

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS (VL  CDR2)

<400>  75

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10NS (VL  CDR3)

<400>  76

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E10 (VH  CDR1)

<400>  77

Asp Asp Tyr Met Ser 
1               5   


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E10 (VH  CDR2)

<400>  78

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E10 (VH  CDR3)

<400>  79

Glu Asp Trp Gly Gly Glu Phe Thr Asp 
1               5                   


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E10 (VL  CDR1)

<400>  80

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E10 (VL  CDR2)

<400>  81

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3E10 (VL  CDR3)

<400>  82

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1g (VH  CDR1)

<400>  83

Asp Asp Tyr Met Ser 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1g (VH  CDR2)

<400>  84

Ser Val Ser Asn Gly Arg Pro Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1g (VH  CDR3)

<400>  85

Glu Gly Trp Ser Gly Glu Phe Thr Asp 
1               5                   


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1g (VL  CDR1)

<400>  86

Ser Gly Ser Ser Ser Asn Ile Gly Phe His Phe Val Tyr 
1               5                   10              


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1g (VL  CDR2)

<400>  87

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3H10m1g (VL  CDR3)

<400>  88

Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val 
1               5                   10      


