                               SEQUENCE LISTING

<110> DICERNA PHARMACEUTICALS, INC.
 
<120> COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRAS ASSOCIATED 
      DISEASES OR DISORDERS

<130> 0243.0034-PCT

<140>
<141>

<150> 62/826,121
<151> 2019-03-29

<160> 55    

<170> PatentIn version 3.5

<210> 1
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 1
ggccugcuga aaaugacuga auata                                             25


<210> 2
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 2
uauauucagu cauuuucagc aggccuc                                           27


<210> 3
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
cuaaaucauu ugaagauauu cacca                                             25


<210> 4
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
uggugaauau cuucaaauga uuuagua                                           27


<210> 5
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 5
guauuugcca uaaauaauac uaaat                                             25


<210> 6
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 6
auuuaguauu auuuauggca aauacac                                           27


<210> 7
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
ggccugcuga aaaugacuga gcagccgaaa ggcugc                                 36


<210> 8
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
ucagucauuu ucagcaggcc uc                                                22


<210> 9
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
cuaaaucauu ugaagauauu gcagccgaaa ggcugc                                 36


<210> 10
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
aauaucuuca aaugauuuag ua                                                22


<210> 11
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
guauuugcca uaaauaauac gcagccgaaa ggcugc                                 36


<210> 12
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
guauuauuua uggcaaauac ac                                                22


<210> 13
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
cuaaaucauu ugaagauaua gcagccgaaa ggcugc                                 36


<210> 14
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 4'-oxymethylphosphonate uracil

<400> 14
nauaucuuca aaugauuuag gg                                                22


<210> 15
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
guauuugcca uaaauaauaa gcagccgaaa ggcugc                                 36


<210> 16
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 4'-oxymethylphosphonate uracil

<400> 16
nuauuauuua uggcaaauac gg                                                22


<210> 17
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
ucagucauuu ucagcaggcc gg                                                22


<210> 18
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
uauaucuuca aaugauuuag gg                                                22


<210> 19
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
uuauuauuua uggcaaauac gg                                                22


<210> 20
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 20
gauggagaaa ccugucucuu ggata                                             25


<210> 21
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
uauccaagag acagguuucu ccaucaa                                           27


<210> 22
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
ucuuggauau ucucgacaca gcagg                                             25


<210> 23
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
ccugcugugu cgagaauauc caagaga                                           27


<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 24
gaguacagug caaugaggga ccagt                                             25


<210> 25
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
acuggucccu cauugcacug uacuccu                                           27


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 26
uugccauaaa uaauacuaaa ucatt                                             25


<210> 27
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
aaugauuuag uauuauuuau ggcaaau                                           27


<210> 28
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 28
cauaaagaaa agaugagcaa agatg                                             25


<210> 29
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
caucuuugcu caucuuuucu uuauguu                                           27


<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 30
uacauuacac uaaauuauua gcatt                                             25


<210> 31
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
aaugcuaaua auuuagugua auguaca                                           27


<210> 32
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
cuaaauuauu agcauuuguu uuagc                                             25


<210> 33
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
gcuaaaacaa augcuaauaa uuuagug                                           27


<210> 34
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
uagcauuugu uuuagcauua ccuaa                                             25


<210> 35
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
uuagguaaug cuaaaacaaa ugcuaau                                           27


<210> 36
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 36
uauauuuaca ugcuacuaaa uuutt                                             25


<210> 37
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
aaaaauuuag uagcauguaa auauagc                                           27


<210> 38
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
gauggagaaa ccugucucuu gcagccgaaa ggcugc                                 36


<210> 39
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
aagagacagg uuucuccauc aa                                                22


<210> 40
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 40
ucuuggauau ucucgacaca gcagccgaaa ggcugc                                 36


<210> 41
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 41
ugugucgaga auauccaaga ga                                                22


<210> 42
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 42
gaguacagug caaugaggga gcagccgaaa ggcugc                                 36


<210> 43
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
ucccucauug cacuguacuc cu                                                22


<210> 44
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
uugccauaaa uaauacuaaa gcagccgaaa ggcugc                                 36


<210> 45
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 45
uuuaguauua uuuauggcaa au                                                22


<210> 46
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 46
cauaaagaaa agaugagcaa gcagccgaaa ggcugc                                 36


<210> 47
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 47
uugcucaucu uuucuuuaug uu                                                22


<210> 48
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 48
uacauuacac uaaauuauua gcagccgaaa ggcugc                                 36


<210> 49
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
uaauaauuua guguaaugua ca                                                22


<210> 50
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 50
cuaaauuauu agcauuuguu gcagccgaaa ggcugc                                 36


<210> 51
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 51
aacaaaugcu aauaauuuag ug                                                22


<210> 52
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 52
uagcauuugu uuuagcauua gcagccgaaa ggcugc                                 36


<210> 53
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 53
uaaugcuaaa acaaaugcua au                                                22


<210> 54
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 54
uauauuuaca ugcuacuaaa gcagccgaaa ggcugc                                 36


<210> 55
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 55
uuuaguagca uguaaauaua gc                                                22


