                         SEQUENCE LISTING

<110>  NantCell
 
<120>  RECOMBINANT erIL-15 NK CELLS

<130>  102538.0075PCT

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized IL-15

<400>  1
atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa       60

aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgataaccg      120

ccaccatgcg catcagcaag ccccacctgc gcagcatcag catccagtgc tacctgtgcc      180

tgctgctgaa cagccacttc ctgaccgagg ccggcatcca cgtgttcatc ctgggctgct      240

tcagcgccgg cctgcccaag accgaggcca actgggtgaa cgtgatcagc gacctgaaga      300

agatcgagga cctgatccag agcatgcaca tcgacgccac cctgtacacc gagagcgacg      360

tgcaccccag ctgcaaggtg accgccatga agtgcttcct gctggagctg caggtgatca      420

gcctggagag cggcgacgcc agcatccacg acaccgtgga gaacctgatc atcctggcca      480

acaacagcct gagcagcaac ggcaacgtga ccgagagcgg ctgcaaggag tgcgaggagc      540

tggaggagaa gaacatcaag gagttcctgc agagcttcgt gcacatcgtg cagatgttca      600

tcaacaccag cggctccgag aaggacgagc tgtaa                                 635


<210>  2
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  long signal peptide variant (LSP-IL-15)

<400>  2
atgcgcatca gcaagcccca cctgcgcagc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac cgaggccggc atccacgtgt tcatcctggg ctgcttcagc      120

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac      240

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg      300

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag      420

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac      480

accagctaa                                                              489


<210>  3
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  long signal peptide variant (LSP-IL-15) peptide seq

<400>  3

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  4
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  erIL-15 Long Signal Peptide nt seq

<400>  4
atgcgcatca gcaagcccca cctgcgcagc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac cgaggccggc atccacgtgt tcatcctggg ctgcttcagc      120

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac      240

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg      300

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag      420

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac      480

accagcggct ccgagaagga cgagctgtaa                                       510


<210>  5
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  erIl-15 Long Signal Peptide peptide seq

<400>  5

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Ser Glu Lys Asp Glu Leu 
                165                 


<210>  6
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15 Short Signal Peptide nt seq

<400>  6
atggtgctgg gcaccatcga cctgtgcagc tgcttcagcg ccggcctgcc caagaccgag       60

gccaactggg tgaacgtgat cagcgacctg aagaagatcg aggacctgat ccagagcatg      120

cacatcgacg ccaccctgta caccgagagc gacgtgcacc ccagctgcaa ggtgaccgcc      180

atgaagtgct tcctgctgga gctgcaggtg atcagcctgg agagcggcga cgccagcatc      240

cacgacaccg tggagaacct gatcatcctg gccaacaaca gcctgagcag caacggcaac      300

gtgaccgaga gcggctgcaa ggagtgcgag gagctggagg agaagaacat caaggagttc      360

ctgcagagct tcgtgcacat cgtgcagatg ttcatcaaca ccagctaa                   408


<210>  7
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15 Peptide Seq

<400>  7

Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


