                         SEQUENCE LISTING

<110>  Lankenau Institute of Medical Research
 
<120>  ANTI-NMDA Receptor Antibodies and Methods of Use

<130>  MLH108PCT

<150>  US 62/826552
<151>  2019-03-29

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  DNA
<213>  artificial sequence

<220>
<223>  5F5 heavy chain nt sequence

<400>  1
caggtgcagc tggtggagtc tggaggaggc gtggtccggc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt acctatagtc ttcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggttggagtt attttatatg atggcagcaa aaaatattat      180

gcagactccg tgaggggccg attcaccatc tccagagaca attccaagag cacgctaaat      240

ctggatatga gcagcctgag acctgacgac acggctgtgt attactgtgc gagagaccca      300

atagcagtgg ctcccaggcc cagcggcatg gtcccccagg gatttgacta ttggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  2
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5F5 light chain nt

<400>  2
cagtctgtcg tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga agaaattttg tattctggta tcggcagctc      120

ccaggaacgg cccccaaagt cctcatctat aagaatattc agcggccctc aggggtccct      180

gaccgaatct ctggctccag gtctggctcc tcagcctccc tggccatcag tggactccgg      240

tccgaggatg aggctgatta ttactgtgca tcatgggatg acagcctgag tggtgtggtg      300

ttcggcgggg ggaccaagct gaccgtccta a                                     331


<210>  3
<211>  392
<212>  DNA
<213>  artificial

<220>
<223>  2G6 heavy chain nt

<400>  3
caggtgcagc tgcaggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctgggtt cagcttcaat gcctttgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcacgc atatcacatt atggaagtga tgactactat      180

gcagactctg tgaagggccg attcaccatc tccagagaca attcccagaa cactctgttt      240

ctgcaaatga acagcctgaa agccgaggac acgggtgtgt attactgttg gaggggattt      300

actctggttc ggggagttat ttcgagaaat cccattaatc gattctccgg tatggacgtc      360

tggggccaag ggaccacggt caccgtctct tc                                    392


<210>  4
<211>  325
<212>  DNA
<213>  artificial

<220>
<223>  2G6 light chain nt

<400>  4
tcctatgagc tgatgcagcc accctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaaa tatgcttatt ggtaccagca gaagtcaggc      120

caggccccta tactggtcat ctatgaggac aacaaacgac cctccgggat ccctgagaga      180

ttctctggct ccagctcagg gacaatggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actacttctg ttattcaaca gacagcagtg gtaatcatgg ggtattcggc      300

ggagggacca agctgaccgt cctaa                                            325


<210>  5
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1D1 heavy chain nt

<400>  5
ttggtgcagc tggtggagtc cgggggaggc gtggtccagt ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttccat acctttacta tacactgggt ccgccaggct      120

ccaggcaagg ggctggactg ggtaacagct atatattttg atggaaccaa aaaatactac      180

gcagactccg tgaagggccg attcaccgtc tccagagaca actccaagaa cacggtatat      240

ctgcaaatga acggcctgag aggtgaggac acggctgtct attactgtgc gagagcccga      300

tacagctatg gcctttcctt tgactactgg ggccagggaa ccccggtcac cgtctcctct      360

g                                                                      361


<210>  6
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1D1 light chain nt

<400>  6
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg caagcagctc ctaccttggg agtaattatg tatcttggta ccagcaactc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgatcctc agggatttct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggacatcac cggcctgcag      240

actggggacg aggccgacta ttactgcgga gcatgggaca gcagcctgag tgtcgtggtt      300

ttcggcggag ggaccaagct gaccgtccta a                                     331


<210>  7
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NMDAR amino terminal domain

<400>  7

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr 
    


<210>  8
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion proteinof N-terminal extracellular domain of human GluN1 
       fused to the Myc epitope tag, a 6XHIS tag, the Tobacco Etch Virus
       (TEV) protease cleavage site and TM domain of human PDGFR


<220>
<221>  ATD
<222>  (1)..(561)
<223>  Human NR1 amino terminal domain

<220>
<221>  Myc
<222>  (562)..(571)
<223>  MYC domain

<220>
<221>  polyHIS
<222>  (572)..(577)
<223>  polyHis sequence

<220>
<221>  Tev
<222>  (578)..(585)
<223>  Tev protease

<220>
<221>  DOMAIN
<222>  (586)..(635)
<223>  transmembrane domain of human PDGFR

<400>  8

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His 
                565                 570                 575     


His Glu Asn Leu Tyr Phe Gln Gly Gly Asn Ala Val Gly Gln Asp Thr 
            580                 585                 590         


Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val Val Val 
        595                 600                 605             


Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser Leu Ile 
    610                 615                 620                 


Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
625                 630                 635 


<210>  9
<211>  1926
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the fusion protein of SEQ ID NO: 8

<400>  9
ggatccgcca ccatgagcac catgcgcctg ctgacgctcg ccctgctgtt ctcctgctcc       60

gtcgcccgtg ccgcgtgcga ccccaagatc gtcaacattg gcgcggtgct gagcacgcgg      120

aagcacgagc agatgttccg cgaggccgtg aaccaggcca acaagcggca cggctcctgg      180

aagattcagc tcaatgccac ctccgtcacg cacaagccca acgccatcca gatggctctg      240

tcggtgtgcg aggacctcat ctccagccag gtctacgcca tcctagttag ccatccacct      300

acccccaacg accacttcac tcccacccct gtctcctaca cagccggctt ctaccgcata      360

cccgtgctgg ggctgaccac ccgcatgtcc atctactcgg acaagagcat ccacctgagc      420

ttcctgcgca ccgtgccgcc ctactcccac cagtccagcg tgtggtttga gatgatgcgt      480

gtctacagct ggaaccacat catcctgctg gtcagcgacg accacgaggg ccgggcggct      540

cagaaacgcc tggagacgct gctggaggag cgtgagtcca aggcagagaa ggtgctgcag      600

tttgacccag ggaccaagaa cgtgacggcc ctgctgatgg aggcgaaaga gctggaggcc      660

cgggtcatca tcctttctgc cagcgaggac gatgctgcca ctgtataccg cgcagccgcg      720

atgctgaaca tgacgggctc cgggtacgtg tggctggtcg gcgagcgcga gatctcgggg      780

aacgccctgc gctacgcccc agacggcatc ctcgggctgc agctcatcaa cggcaagaac      840

gagtcggccc acatcagcga cgccgtgggc gtggtggccc aggccgtgca cgagctcctc      900

gagaaggaga acatcaccga cccgccgcgg ggctgcgtgg gcaacaccaa catctggaag      960

accgggccgc tcttcaagag agtgctgatg tcttccaagt atgcggatgg ggtgactggt     1020

cgcgtggagt tcaatgagga tggggaccgg aagttcgcca actacagcat catgaacctg     1080

cagaaccgca agctggtgca agtgggcatc tacaatggca cccacgtcat ccctaatgac     1140

aggaagatca tctggccagg cggagagaca gagaagcctc gagggtacca gatgtccacc     1200

agactgaaga ttgtgacgat ccaccaggag cccttcgtgt acgtcaagcc cacgctgagt     1260

gatgggacat gcaaggagga gttcacagtc aacggcgacc cagtcaagaa ggtgatctgc     1320

accgggccca acgacacgtc gccgggcagc ccccgccaca cggtgcctca gtgttgctac     1380

ggcttttgca tcgacctgct catcaagctg gcacggacca tgaacttcac ctacgaggtg     1440

cacctggtgg cagatggcaa gttcggcaca caggagcggg tgaacaacag caacaagaag     1500

gagtggaatg ggatgatggg cgagctgctc agcgggcagg cagacatgat cgtggcgccg     1560

ctaaccataa acaacgagcg cgcgcagtac atcgagtttt ccaagccctt caagtaccag     1620

ggcctgacta ttctggtcaa gaaggagatt ccccggagca cgctggactc gttcatgcag     1680

ccgttccaga gcacagaaca aaaactcatc tcagaagagg atctgcatca tcaccatcac     1740

cacgaaaacc tgtattttca gggcggcaac gctgtgggcc aggacacgca ggaggtcatc     1800

gtggtgccac actccttgcc ctttaaggtg gtggtgatct cagccatcct ggccctggtg     1860

gtgctcacca tcatctccct tatcatcctc atcatgcttt ggcagaagaa gccacgttag     1920

gaattc                                                                1926


<210>  10
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F5 heavy chain AA


<220>
<221>  CDR
<222>  (97)..(117)
<223>  CDR region

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Leu Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Asn 
65                  70                  75                  80  


Leu Asp Met Ser Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ile Ala Val Ala Pro Arg Pro Ser Gly Met Val Pro 
            100                 105                 110         


Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  11
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F5 light chain AA


<220>
<221>  CDR
<222>  (88)..(101)
<223>  CDR region

<400>  11

Gln Ser Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Phe Val Phe Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Lys Asn Ile Gln Arg Pro Ser Gly Val Pro Asp Arg Ile Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  12
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G6 heavy chain AA


<220>
<221>  CDR
<222>  (97)..(120)
<223>  CDR region

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Ala Phe 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Ser His Tyr Gly Ser Asp Asp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Trp Arg Gly Phe Thr Leu Val Arg Gly Val Ile Ser Arg Asn Pro Ile 
            100                 105                 110         


Asn Arg Phe Ser Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser 
    130 


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2G6 light chain AA


<220>
<221>  CDR
<222>  (87)..(99)
<223>  CDR region

<400>  13

Ser Tyr Glu Leu Met Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D1 heavy chain AA


<220>
<221>  CDR
<222>  (97)..(109)
<223>  CDR region

<400>  14

Leu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe His Thr Phe 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Thr Ala Ile Tyr Phe Asp Gly Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Tyr Ser Tyr Gly Leu Ser Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Pro Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D1 light chain AA


<220>
<221>  CDR
<222>  (91)..(101)
<223>  CDR region

<400>  15

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Tyr Leu Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Ser Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV protease site

<400>  16

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV protease site

<400>  17

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


