                         SEQUENCE LISTING

<110>  Immunetune B.V.
 
<120>  Immune-stimulatory compositions and use thereof

<130>  P122264PC00

<140>  PCT/NL2020/050225
<141>  2020-04-02

<150>  EP 19166877.1
<151>  2019-04-02

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  402
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Asp Lys Ile Leu Arg Ala Lys Arg Lys Gln Phe Ile Asn Ser 
1               5                   10                  15      


Val Ser Ile Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Glu Lys 
            20                  25                  30          


Arg Val Leu Asn Gln Glu Glu Met Asp Lys Ile Lys Leu Ala Asn Ile 
        35                  40                  45              


Thr Ala Met Asp Lys Ala Arg Asp Leu Cys Asp His Val Ser Lys Lys 
    50                  55                  60                  


Gly Pro Gln Ala Ser Gln Ile Phe Ile Thr Tyr Ile Cys Asn Glu Asp 
65                  70                  75                  80  


Cys Tyr Leu Ala Gly Ile Leu Glu Leu Gln Ser Ala Pro Ser Ala Glu 
                85                  90                  95      


Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly His Pro Ser Ser Ser 
            100                 105                 110         


Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly Thr Phe Pro Gly Leu 
        115                 120                 125             


Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys Ala Gln Lys Leu Trp 
    130                 135                 140                 


Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met Asn Thr Thr Thr Arg 
145                 150                 155                 160 


Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu Phe Gln His Leu Ser 
                165                 170                 175     


Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu Met Lys Leu Leu Leu 
            180                 185                 190         


Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu Asn Leu Thr Ala Leu 
        195                 200                 205             


Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala Cys Pro Glu His Lys 
    210                 215                 220                 


Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Gln Glu 
225                 230                 235                 240 


Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val Ser Asp Ile Leu Lys 
                245                 250                 255     


Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu Lys Cys Pro Ser Leu 
            260                 265                 270         


Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Glu Lys 
        275                 280                 285             


Gln Gly Val Val Leu Leu Lys Asp Ser Val Arg Asp Ser Glu Glu Asp 
    290                 295                 300                 


Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly Ile Lys Lys Ala His 
305                 310                 315                 320 


Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val 
                325                 330                 335     


Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe Ile Glu Ser Leu Ile 
            340                 345                 350         


Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp Leu Glu Asp Ile Phe 
        355                 360                 365             


Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu Phe Arg Leu Gln Met 
    370                 375                 380                 


Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg Phe Tyr Leu Phe Pro 
385                 390                 395                 400 


Gly His 
        


<210>  2
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_C285G

<400>  2

Met Ala Asp Lys Ile Leu Arg Ala Lys Arg Lys Gln Phe Ile Asn Ser 
1               5                   10                  15      


Val Ser Ile Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Glu Lys 
            20                  25                  30          


Arg Val Leu Asn Gln Glu Glu Met Asp Lys Ile Lys Leu Ala Asn Ile 
        35                  40                  45              


Thr Ala Met Asp Lys Ala Arg Asp Leu Cys Asp His Val Ser Lys Lys 
    50                  55                  60                  


Gly Pro Gln Ala Ser Gln Ile Phe Ile Thr Tyr Ile Cys Asn Glu Asp 
65                  70                  75                  80  


Cys Tyr Leu Ala Gly Ile Leu Glu Leu Gln Ser Ala Pro Ser Ala Glu 
                85                  90                  95      


Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly His Pro Ser Ser Ser 
            100                 105                 110         


Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly Thr Phe Pro Gly Leu 
        115                 120                 125             


Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys Ala Gln Lys Leu Trp 
    130                 135                 140                 


Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met Asn Thr Thr Thr Arg 
145                 150                 155                 160 


Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu Phe Gln His Leu Ser 
                165                 170                 175     


Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu Met Lys Leu Leu Leu 
            180                 185                 190         


Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu Asn Leu Thr Ala Leu 
        195                 200                 205             


Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala Cys Pro Glu His Lys 
    210                 215                 220                 


Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Gln Glu 
225                 230                 235                 240 


Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val Ser Asp Ile Leu Lys 
                245                 250                 255     


Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu Lys Cys Pro Ser Leu 
            260                 265                 270         


Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Gly Arg Gly Glu Lys 
        275                 280                 285             


Gln Gly Val Val Leu Leu Lys Asp Ser Val Arg Asp Ser Glu Glu Asp 
    290                 295                 300                 


Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly Ile Lys Lys Ala His 
305                 310                 315                 320 


Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val 
                325                 330                 335     


Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe Ile Glu Ser Leu Ile 
            340                 345                 350         


Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp Leu Glu Asp Ile Phe 
        355                 360                 365             


Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu Phe Arg Leu Gln Met 
    370                 375                 380                 


Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg Phe Tyr Leu Phe Pro 
385                 390                 395                 400 


Gly His 
        


<210>  3
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV

<400>  3

Met Val Leu Leu Lys Asp Ser Val Arg Asp Ser Glu Glu Asp Phe Leu 
1               5                   10                  15      


Thr Asp Ala Ile Phe Glu Asp Asp Gly Ile Lys Lys Ala His Ile Glu 
            20                  25                  30          


Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val Ser Trp 
        35                  40                  45              


Arg His Pro Val Arg Gly Ser Leu Phe Ile Glu Ser Leu Ile Lys His 
    50                  55                  60                  


Met Lys Glu Tyr Ala Trp Ser Cys Asp Leu Glu Asp Ile Phe Arg Lys 
65                  70                  75                  80  


Val Arg Phe Ser Phe Glu Gln Pro Glu Phe Arg Leu Gln Met Pro Thr 
                85                  90                  95      


Ala Asp Arg Val Thr Leu Thr Lys Arg Phe Tyr Leu Phe Pro Gly His 
            100                 105                 110         


Leu Leu Val Cys Asp Val Pro Ile Arg Ala Pro Ser Ala Glu Thr Phe 
        115                 120                 125             


Val Ala Thr Glu Asp Ser Lys Gly Gly His Pro Ser Ser Ser Glu Thr 
    130                 135                 140                 


Lys Glu Glu Gln Asn Lys Glu Asp Gly Thr Phe Pro Gly Leu Thr Gly 
145                 150                 155                 160 


Thr Leu Lys Phe Cys Pro Leu Glu Lys Ala Gln Lys Leu Trp Lys Glu 
                165                 170                 175     


Asn Pro Ser Glu Ile Tyr Pro Ile Met Asn Thr Thr Thr Arg Thr Arg 
            180                 185                 190         


Leu Ala Leu Ile Ile Cys Asn Thr Glu Phe Gln His Leu Ser Pro Arg 
        195                 200                 205             


Val Gly Ala Gln Val Asp Leu Arg Glu Met Lys Leu Leu Leu Glu Asp 
    210                 215                 220                 


Leu Gly Tyr Thr Val Lys Val Lys Glu Asn Leu Thr Ala Leu Glu Met 
225                 230                 235                 240 


Val Lys Glu Val Lys Glu Phe Ala Ala Cys Pro Glu His Lys Thr Ser 
                245                 250                 255     


Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Gln Glu Gly Ile 
            260                 265                 270         


Cys Gly Thr Thr Tyr Ser Asn Glu Val Ser Asp Ile Leu Lys Val Asp 
        275                 280                 285             


Thr Ile Phe Gln Met Met Asn Thr Leu Lys Cys Pro Ser Leu Lys Asp 
    290                 295                 300                 


Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Glu Lys Gln Gly 
305                 310                 315                 320 


Val Val Leu Leu Lys Asp 
                325     


<210>  4
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2

<400>  4

Met Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe 
        35                  40                  45              


Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp 
    50                  55                  60                  


Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu 
65                  70                  75                  80  


Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Asp Val Pro Ile Arg 
            100                 105                 110         


Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly 
        115                 120                 125             


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly 
    130                 135                 140                 


Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys 
145                 150                 155                 160 


Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met 
                165                 170                 175     


Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu 
            180                 185                 190         


Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu 
        195                 200                 205             


Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu 
    210                 215                 220                 


Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala 
225                 230                 235                 240 


Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser 
                245                 250                 255     


His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val 
            260                 265                 270         


Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu 
        275                 280                 285             


Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala 
    290                 295                 300                 


Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
305                 310                 315         


<210>  5
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Casp1 S, p10 (AA315-402)

<400>  5

Gly Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser 
1               5                   10                  15      


Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu 
            20                  25                  30          


Phe Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys 
        35                  40                  45              


Asp Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro 
    50                  55                  60                  


Glu Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys 
65                  70                  75                  80  


Arg Phe Tyr Leu Phe Pro Gly His 
                85              


<210>  6
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  6

Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly 
1               5                   10                  15      


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln 
            20                  25          


<210>  7
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  7

Leu Leu Val Cys Asp Val Pro Ile Arg 
1               5                   


<210>  8
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iCASP1

<400>  8

Met Gly Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
1               5                   10                  15      


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
            20                  25                  30          


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
        35                  40                  45              


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
    50                  55                  60                  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
65                  70                  75                  80  


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
                85                  90                  95      


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr 
            100                 105                 110         


Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
        115                 120                 125             


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
    130                 135                 140                 


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
145                 150                 155                 160 


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
                165                 170                 175     


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
            180                 185                 190         


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
        195                 200                 205             


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly 
    210                 215                 220                 


Ser Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly 
225                 230                 235                 240 


Gly His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp 
                245                 250                 255     


Gly Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu 
            260                 265                 270         


Lys Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile 
        275                 280                 285             


Met Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr 
    290                 295                 300                 


Glu Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg 
305                 310                 315                 320 


Glu Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys 
                325                 330                 335     


Glu Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala 
            340                 345                 350         


Ala Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met 
        355                 360                 365             


Ser His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu 
    370                 375                 380                 


Val Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr 
385                 390                 395                 400 


Leu Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln 
                405                 410                 415     


Ala Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp Ser Val 
            420                 425                 430         


Arg Asp Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp 
        435                 440                 445             


Gly Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser 
    450                 455                 460                 


Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu 
465                 470                 475                 480 


Phe Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys 
                485                 490                 495     


Asp Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro 
            500                 505                 510         


Glu Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys 
        515                 520                 525             


Arg Phe Tyr Leu Phe Pro Gly His 
    530                 535     


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SGGGS linker

<400>  9

Ser Gly Gly Gly Ser 
1               5   


<210>  10
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F36V-FKBP

<400>  10

Met Gly Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
1               5                   10                  15      


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
            20                  25                  30          


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
        35                  40                  45              


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
    50                  55                  60                  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
65                  70                  75                  80  


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
                85                  90                  95      


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr 
            100                 105                 110         


Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
        115                 120                 125             


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
    130                 135                 140                 


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
145                 150                 155                 160 


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
                165                 170                 175     


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
            180                 185                 190         


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
        195                 200                 205             


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    210                 215                 220 


<210>  11
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F36M-FKBP

<400>  11

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Met Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Arg Gly Val 
            100                 105                 110         


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
        115                 120                 125             


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
    130                 135                 140                 


Lys Met Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
145                 150                 155                 160 


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
                165                 170                 175     


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
            180                 185                 190         


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
        195                 200                 205             


Phe Asp Val Glu Leu Leu Lys Leu Glu 
    210                 215         


<210>  12
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCASP1

<400>  12

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Met Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Arg Gly Val 
            100                 105                 110         


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
        115                 120                 125             


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
    130                 135                 140                 


Lys Met Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
145                 150                 155                 160 


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
                165                 170                 175     


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
            180                 185                 190         


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
        195                 200                 205             


Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Ser Ala Pro 
    210                 215                 220                 


Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly His Pro 
225                 230                 235                 240 


Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly Thr Phe 
                245                 250                 255     


Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys Ala Gln 
            260                 265                 270         


Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met Asn Thr 
        275                 280                 285             


Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu Phe Gln 
    290                 295                 300                 


His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu Met Lys 
305                 310                 315                 320 


Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu Asn Leu 
                325                 330                 335     


Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala Cys Pro 
            340                 345                 350         


Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly 
        355                 360                 365             


Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val Ser Asp 
    370                 375                 380                 


Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu Lys Cys 
385                 390                 395                 400 


Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg 
                405                 410                 415     


Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp Ser Val Arg Asp Ser 
            420                 425                 430         


Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly Ile Lys 
        435                 440                 445             


Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro 
    450                 455                 460                 


Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe Ile Glu 
465                 470                 475                 480 


Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp Leu Glu 
                485                 490                 495     


Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu Phe Arg 
            500                 505                 510         


Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg Phe Tyr 
        515                 520                 525             


Leu Phe Pro Gly His 
    530             


<210>  13
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dasher GFP

<400>  13

Met Thr Ala Leu Thr Glu Gly Ala Lys Leu Phe Glu Lys Glu Ile Pro 
1               5                   10                  15      


Tyr Ile Thr Glu Leu Glu Gly Asp Val Glu Gly Met Lys Phe Ile Ile 
            20                  25                  30          


Lys Gly Glu Gly Thr Gly Asp Ala Thr Thr Gly Thr Ile Lys Ala Lys 
        35                  40                  45              


Tyr Ile Cys Thr Thr Gly Asp Leu Pro Val Pro Trp Ala Thr Leu Val 
    50                  55                  60                  


Ser Thr Leu Ser Tyr Gly Val Gln Cys Phe Ala Lys Tyr Pro Ser His 
65                  70                  75                  80  


Ile Lys Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Thr Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Glu Gly Asp Gly Val Tyr Lys Thr Arg Ala Met 
            100                 105                 110         


Val Thr Tyr Glu Arg Gly Ser Ile Tyr Asn Arg Val Thr Leu Thr Gly 
        115                 120                 125             


Glu Asn Phe Lys Lys Asp Gly His Ile Leu Arg Lys Asn Val Ala Phe 
    130                 135                 140                 


Gln Cys Pro Pro Ser Ile Leu Tyr Ile Leu Pro Asp Thr Val Asn Asn 
145                 150                 155                 160 


Gly Ile Arg Val Glu Phe Asn Gln Ala Tyr Asp Ile Glu Gly Val Thr 
                165                 170                 175     


Glu Lys Leu Val Thr Lys Cys Ser Gln Met Asn Arg Pro Leu Ala Gly 
            180                 185                 190         


Ser Ala Ala Val His Ile Pro Arg Tyr His His Ile Thr Tyr His Thr 
        195                 200                 205             


Lys Leu Ser Lys Asp Arg Asp Glu Arg Arg Asp His Met Cys Leu Val 
    210                 215                 220                 


Glu Val Val Lys Ala Val Asp Leu Asp Thr Tyr Gln 
225                 230                 235     


<210>  14
<211>  276
<212>  PRT
<213>  Mus musculus

<400>  14

Met Pro Ser Ala Phe Glu Lys Val Val Lys Asn Val Ile Lys Glu Val 
1               5                   10                  15      


Ser Gly Ser Arg Gly Asp Leu Ile Pro Val Asp Ser Leu Arg Asn Ser 
            20                  25                  30          


Thr Ser Phe Arg Pro Tyr Cys Leu Leu Asn Arg Lys Phe Ser Ser Ser 
        35                  40                  45              


Arg Phe Trp Lys Pro Arg Tyr Ser Cys Val Asn Leu Ser Ile Lys Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ala Pro Glu Pro Glu Pro Glu Cys Phe Gly Ser 
65                  70                  75                  80  


Phe Lys Val Ser Asp Val Val Asp Gly Asn Ile Gln Gly Arg Val Met 
                85                  90                  95      


Leu Ser Gly Met Gly Glu Gly Lys Ile Ser Gly Gly Ala Ala Val Ser 
            100                 105                 110         


Asp Ser Ser Ser Ala Ser Met Asn Val Cys Ile Leu Arg Val Thr Gln 
        115                 120                 125             


Lys Thr Trp Glu Thr Met Gln His Glu Arg His Leu Gln Gln Pro Glu 
    130                 135                 140                 


Asn Lys Ile Leu Gln Gln Leu Arg Ser Arg Gly Asp Asp Leu Phe Val 
145                 150                 155                 160 


Val Thr Glu Val Leu Gln Thr Lys Glu Glu Val Gln Ile Thr Glu Val 
                165                 170                 175     


His Ser Gln Glu Gly Ser Gly Gln Phe Thr Leu Pro Gly Ala Leu Cys 
            180                 185                 190         


Leu Lys Gly Glu Gly Lys Gly His Gln Ser Arg Lys Lys Met Val Thr 
        195                 200                 205             


Ile Pro Ala Gly Ser Ile Leu Ala Phe Arg Val Ala Gln Leu Leu Ile 
    210                 215                 220                 


Gly Ser Lys Trp Asp Ile Leu Leu Val Ser Asp Glu Lys Gln Arg Thr 
225                 230                 235                 240 


Phe Glu Pro Ser Ser Gly Asp Arg Lys Ala Val Gly Gln Arg His His 
                245                 250                 255     


Gly Leu Asn Val Leu Ala Ala Leu Cys Ser Ile Gly Lys Gln Leu Ser 
            260                 265                 270         


Leu Leu Ser Asp 
        275     


<210>  15
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSDMD_NTER_FLAG

<400>  15

Met Pro Ser Ala Phe Glu Lys Val Val Lys Asn Val Ile Lys Glu Val 
1               5                   10                  15      


Ser Gly Ser Arg Gly Asp Leu Ile Pro Val Asp Ser Leu Arg Asn Ser 
            20                  25                  30          


Thr Ser Phe Arg Pro Tyr Cys Leu Leu Asn Arg Lys Phe Ser Ser Ser 
        35                  40                  45              


Arg Phe Trp Lys Pro Arg Tyr Ser Cys Val Asn Leu Ser Ile Lys Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ala Pro Glu Pro Glu Pro Glu Cys Phe Gly Ser 
65                  70                  75                  80  


Phe Lys Val Ser Asp Val Val Asp Gly Asn Ile Gln Gly Arg Val Met 
                85                  90                  95      


Leu Ser Gly Met Gly Glu Gly Lys Ile Ser Gly Gly Ala Ala Val Ser 
            100                 105                 110         


Asp Ser Ser Ser Ala Ser Met Asn Val Cys Ile Leu Arg Val Thr Gln 
        115                 120                 125             


Lys Thr Trp Glu Thr Met Gln His Glu Arg His Leu Gln Gln Pro Glu 
    130                 135                 140                 


Asn Lys Ile Leu Gln Gln Leu Arg Ser Arg Gly Asp Asp Leu Phe Val 
145                 150                 155                 160 


Val Thr Glu Val Leu Gln Thr Lys Glu Glu Val Gln Ile Thr Glu Val 
                165                 170                 175     


His Ser Gln Glu Gly Ser Gly Gln Phe Thr Leu Pro Gly Ala Leu Cys 
            180                 185                 190         


Leu Lys Gly Glu Gly Lys Gly His Gln Ser Arg Lys Lys Met Val Thr 
        195                 200                 205             


Ile Pro Ala Gly Ser Ile Leu Ala Phe Arg Val Ala Gln Leu Leu Ile 
    210                 215                 220                 


Gly Ser Lys Trp Asp Ile Leu Leu Val Ser Asp Glu Lys Gln Arg Thr 
225                 230                 235                 240 


Phe Glu Pro Ser Ser Gly Asp Arg Lys Ala Val Gly Gln Arg His His 
                245                 250                 255     


Gly Leu Asn Val Leu Ala Ala Leu Cys Ser Ile Gly Lys Gln Leu Ser 
            260                 265                 270         


Leu Leu Ser Asp Asp Tyr Lys Asp Asp Asp Asp Lys 
        275                 280                 


<210>  16
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLKL_FLAG_MT

<400>  16

Met Asp Lys Leu Gly Gln Ile Ile Lys Leu Gly Gln Leu Ile Tyr Glu 
1               5                   10                  15      


Gln Cys Glu Lys Met Lys Tyr Cys Arg Lys Gln Cys Gln Arg Leu Gly 
            20                  25                  30          


Asn Arg Val His Gly Leu Leu Gln Pro Leu Gln Arg Leu Gln Ala Gln 
        35                  40                  45              


Gly Lys Lys Asn Leu Pro Asp Asp Ile Thr Ala Ala Leu Gly Arg Phe 
    50                  55                  60                  


Asp Glu Val Leu Lys Glu Ala Asn Gln Gln Ile Glu Lys Phe Ser Lys 
65                  70                  75                  80  


Lys Ser His Ile Trp Lys Phe Val Ser Val Gly Asn Asp Lys Ile Leu 
                85                  90                  95      


Phe His Glu Val Asn Glu Lys Leu Arg Asp Val Trp Glu Glu Leu Leu 
            100                 105                 110         


Leu Leu Leu Gln Val Tyr His Trp Asn Thr Val Ser Asp Val Ser Gln 
        115                 120                 125             


Pro Ala Ser Trp Gln Gln Glu Asp Arg Gln Asp Ala Glu Glu Asp Gly 
    130                 135                 140                 


Asn Glu Asn Met Lys Val Ile Leu Met Gln Leu Gln Ile Ser Val Glu 
145                 150                 155                 160 


Glu Ile Asn Lys Thr Leu Lys Gln Cys Ser Leu Lys Pro Thr Gln Glu 
                165                 170                 175     


Ile Pro Gln Asp Leu Gln Ile Lys Glu Ile Pro Lys Glu His Leu Gly 
            180                 185                 190         


Pro Pro Trp Thr Lys Leu Lys Thr Ser Lys Met Ser Thr Ile Tyr Arg 
        195                 200                 205             


Gly Glu Tyr His Arg Ser Pro Val Thr Ile Lys Val Phe Asn Asn Pro 
    210                 215                 220                 


Gln Ala Glu Ser Val Gly Ile Val Arg Phe Thr Phe Asn Asp Glu Ile 
225                 230                 235                 240 


Lys Thr Met Lys Lys Phe Asp Ser Pro Asn Ile Leu Arg Ile Phe Gly 
                245                 250                 255     


Ile Cys Ile Asp Gln Thr Val Lys Pro Pro Glu Phe Ser Ile Val Met 
            260                 265                 270         


Glu Tyr Cys Glu Leu Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys 
        275                 280                 285             


Asp Leu Thr Met Ser Val Arg Ser Leu Leu Val Leu Arg Ala Ala Arg 
    290                 295                 300                 


Gly Leu Tyr Arg Leu His His Ser Glu Thr Leu His Arg Asn Ile Ser 
305                 310                 315                 320 


Ser Ser Ser Phe Leu Val Ala Gly Gly Tyr Gln Val Lys Leu Ala Gly 
                325                 330                 335     


Phe Glu Leu Ser Lys Thr Ala Asn Ser Ile Ser Arg Thr Ala Lys Ser 
            340                 345                 350         


Thr Lys Ala Glu Arg Ser Ser Ser Thr Ile Tyr Val Ser Pro Glu Arg 
        355                 360                 365             


Leu Lys Asn Pro Phe Cys Leu Tyr Asp Ile Lys Ala Glu Ile Tyr Ser 
    370                 375                 380                 


Phe Gly Ile Val Leu Trp Glu Ile Ala Thr Gly Lys Ile Pro Phe Glu 
385                 390                 395                 400 


Gly Cys Asp Ser Lys Lys Ile Arg Glu Leu Val Ala Glu Asp Lys Lys 
                405                 410                 415     


Gln Glu Pro Val Gly Gln Asp Cys Pro Glu Leu Leu Arg Glu Ile Ile 
            420                 425                 430         


Asn Glu Cys Arg Ala His Glu Pro Ser Gln Arg Pro Ser Val Asp Gly 
        435                 440                 445             


Ile Leu Glu Arg Leu Ser Ala Val Glu Glu Ser Thr Asp Lys Lys Val 
    450                 455                 460                 


Asp Tyr Lys Asp Asp Asp Asp Lys 
465                 470         


<210>  17
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  17

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
            20                  25                  30          


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
        35                  40                  45              


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
    50                  55                  60                  


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
65                  70                  75                  80  


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
                85                  90                  95      


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
            100                 105                 110         


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
        115                 120                 125             


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
    130                 135                 140                 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
145                 150                 155                 160 


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
                165                 170             


<210>  18
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  18

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg 
            20                  25                  30          


Thr Asn Ile Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys 
        35                  40                  45              


Ile Asn Leu Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr 
    50                  55                  60                  


Glu Lys Met Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu 
65                  70                  75                  80  


Gln Asn Val Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp 
                85                  90                  95      


Asn Glu Thr Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr 
            100                 105                 110         


Val Phe Leu Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr 
        115                 120                 125             


Trp Glu Met Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg 
    130                 135                 140                 


Val Gln Arg Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met 
145                 150                 155                 160 


Val Val Arg Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu 
                165                 170                 175     


Thr Arg Asn Phe Gln Asn 
            180         


<210>  19
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ddx58_FLAG_RIGI_NTER

<400>  19

Met Asp Tyr Lys Asp Asp Asp Asp Lys Thr Ala Glu Gln Arg Gln Asn 
1               5                   10                  15      


Leu Gln Ala Phe Arg Asp Tyr Ile Lys Lys Ile Leu Asp Pro Thr Tyr 
            20                  25                  30          


Ile Leu Ser Tyr Met Ser Ser Trp Leu Glu Asp Glu Glu Val Gln Tyr 
        35                  40                  45              


Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro Met Glu Ala Ala Ser Leu 
    50                  55                  60                  


Phe Leu Gln Tyr Leu Leu Lys Leu Gln Ser Glu Gly Trp Phe Gln Ala 
65                  70                  75                  80  


Phe Leu Asp Ala Leu Tyr His Ala Gly Tyr Cys Gly Leu Cys Glu Ala 
                85                  90                  95      


Ile Glu Ser Trp Asp Phe Gln Lys Ile Glu Lys Leu Glu Glu His Arg 
            100                 105                 110         


Leu Leu Leu Arg Arg Leu Glu Pro Glu Phe Lys Ala Thr Val Asp Pro 
        115                 120                 125             


Asn Asp Ile Leu Ser Glu Leu Ser Glu Cys Leu Ile Asn Gln Glu Cys 
    130                 135                 140                 


Glu Glu Ile Arg Gln Ile Arg Asp Thr Lys Gly Arg Met Ala Gly Ala 
145                 150                 155                 160 


Glu Lys Met Ala Glu Cys Leu Ile Arg Ser Asp Lys Glu Asn Trp Pro 
                165                 170                 175     


Lys Val Leu Gln Leu Ala Leu Glu Lys Asp Asn Ser Lys Phe Ser Glu 
            180                 185                 190         


Leu Trp Ile Val Asp Lys Gly Phe Lys Arg Ala Glu Ser Lys Ala Asp 
        195                 200                 205             


Glu Asp Asp Gly Ala Glu Ala Ser Ser Ile Gln Ile Phe Ile Gln Glu 
    210                 215                 220                 


Glu Pro Glu Cys Gln Asn Leu Ser Gln Asn Pro Gly Pro Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Ser Asn Asn Leu His Ser Pro Leu Lys Pro Arg Asn Tyr Gln 
                245                 250                 255     


Leu Glu Leu Ala Leu Pro Ala Lys Lys Gly Lys Asn Thr Ile Ile Cys 
            260                 265                 270         


Ala Pro Thr Gly Cys Gly Lys Thr Phe Val Ser Leu Leu Ile Cys Glu 
        275                 280                 285             


His His Leu Lys 
    290         


<210>  20
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reps1 non relevant protein

<400>  20

Met Lys Lys Val Val Val Asn Gly Arg Val Leu Glu Leu Phe Arg Ala 
1               5                   10                  15      


Ala Gln Leu Ala Asn Asp Val Val Leu Gln Ile Met Glu Leu Cys Gly 
            20                  25                  30          


Ala Thr Arg Leu Gly Tyr Phe Gly Arg 
        35                  40      


<210>  21
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  21

Met Ala Thr Val Pro Glu Leu Asn Cys Glu Met Pro Pro Phe Asp Ser 
1               5                   10                  15      


Asp Glu Asn Asp Leu Phe Phe Glu Val Asp Gly Pro Gln Lys Met Lys 
            20                  25                  30          


Gly Cys Phe Gln Thr Phe Asp Leu Gly Cys Pro Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Gln Ile Ser Gln Gln His Ile Asn Lys Ser Phe Arg Gln Ala Val 
    50                  55                  60                  


Ser Leu Ile Val Ala Val Glu Lys Leu Trp Gln Leu Pro Val Ser Phe 
65                  70                  75                  80  


Pro Trp Thr Phe Gln Asp Glu Asp Met Ser Thr Phe Phe Ser Phe Ile 
                85                  90                  95      


Phe Glu Glu Glu Pro Ile Leu Cys Asp Ser Trp Asp Asp Asp Asp Asn 
            100                 105                 110         


Leu Leu Val Cys Asp Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
        115                 120                 125             


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
    130                 135                 140                 


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
145                 150                 155                 160 


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
                165                 170                 175     


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
            180                 185                 190         


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
        195                 200                 205             


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
    210                 215                 220                 


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
225                 230                 235                 240 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
                245                 250                 255     


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
            260                 265                 


<210>  22
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  22

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
            20                  25                  30          


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
        35                  40                  45              


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
    50                  55                  60                  


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
65                  70                  75                  80  


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
                85                  90                  95      


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
            100                 105                 110         


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
        115                 120                 125             


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
    130                 135                 140                 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
145                 150                 155                 160 


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
                165                 170             


<210>  23
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyepitope vaccine

<400>  23

Met Ala Glu Ala Gly Gln Ser Leu Val Ile Ser Ala Ser Ile Ile Val 
1               5                   10                  15      


Phe Asn Leu Leu Glu Leu Glu Gly Asp Tyr Arg Asp Asp His Ile Phe 
            20                  25                  30          


Ser Leu Tyr Phe Met Ala Ala Ala Lys Val Val Val Asn Gly Arg Val 
        35                  40                  45              


Leu Glu Leu Phe Arg Ala Ala Gln Leu Ala Asn Asp Val Val Leu Gln 
    50                  55                  60                  


Ile Met Glu Leu Cys Gly Ala Thr Arg Leu Gly Ala Ala Ala Asp Ile 
65                  70                  75                  80  


Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Met 
                85                  90                  95      


Glu Leu Met Ser Ser Ile Val His Gln Gln Val Phe Pro Thr Val Ala 
            100                 105                 110         


Ser Ala Ala Ala Gly Ile Ser Ser Ala Glu Ser Leu Lys Ile Ser Gln 
        115                 120                 125             


Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg Glu Val 
    130                 135                 140                 


Val Gly Ser Ala Glu Ala Gly Ala Ala Ala Leu Leu Pro Asp Glu Val 
145                 150                 155                 160 


Ser Gly Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr 
                165                 170                 175     


Glu Trp Thr Ser Ser Asn Val Met Glu Glu Arg Lys Ile 
            180                 185                 


<210>  24
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  24

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210>  25
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dpagt1 tumor specific adjuvant

<400>  25

Glu Ala Gly Gln Ser Leu Val Ile Ser Ala Ser Ile Ile Val Phe Asn 
1               5                   10                  15      


Leu Leu Glu Leu Glu Gly Asp Tyr Arg Asp Asp His Ile Phe Ser Leu 
            20                  25                  30          


Tyr Phe Met 
        35  


<210>  26
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reps1 tumor specific adjuvant

<400>  26

Lys Val Val Val Asn Gly Arg Val Leu Glu Leu Phe Arg Ala Ala Gln 
1               5                   10                  15      


Leu Ala Asn Asp Val Val Leu Gln Ile Met Glu Leu Cys Gly Ala Thr 
            20                  25                  30          


Arg Leu Gly 
        35  


<210>  27
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adpgk tumor-specific adjuvant

<400>  27

Asp Ile Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr 
1               5                   10                  15      


Asn Met Glu Leu Met Ser Ser Ile Val His Gln Gln Val Phe Pro Thr 
            20                  25                  30          


Val Ala Ser 
        35  


<210>  28
<211>  35
<212>  PRT
<213>  Gallus gallus

<400>  28

Gly Ile Ser Ser Ala Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala 
1               5                   10                  15      


Ala His Ala Glu Ile Asn Glu Ala Gly Arg Glu Val Val Gly Ser Ala 
            20                  25                  30          


Glu Ala Gly 
        35  


<210>  29
<211>  35
<212>  PRT
<213>  Gallus gallus

<400>  29

Leu Leu Pro Asp Glu Val Ser Gly Leu Glu Gln Leu Glu Ser Ile Ile 
1               5                   10                  15      


Asn Phe Glu Lys Leu Thr Glu Trp Thr Ser Ser Asn Val Met Glu Glu 
            20                  25                  30          


Arg Lys Ile 
        35  


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  30

Ala Ala Ala 
1           


<210>  31
<211>  312
<212>  PRT
<213>  Mus musculus

<400>  31

Met Gly Ser Thr Ala Arg Thr Gly His Phe Val Asp Gln His Arg Gln 
1               5                   10                  15      


Ala Leu Ile Ala Arg Val Thr Glu Val Asp Gly Val Leu Asp Ala Leu 
            20                  25                  30          


His Gly Ser Val Leu Thr Glu Gly Gln Tyr Gln Ala Val Arg Ala Glu 
        35                  40                  45              


Thr Thr Ser Gln Asp Lys Met Arg Lys Leu Phe Ser Phe Val Pro Ser 
    50                  55                  60                  


Trp Asn Leu Thr Cys Lys Asp Ser Leu Leu Gln Ala Leu Lys Glu Ile 
65                  70                  75                  80  


His Pro Tyr Leu Val Met Asp Leu Glu Gln Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
            100                 105                 110         


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
        115                 120                 125             


Gly Lys Lys Met Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
    130                 135                 140                 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
145                 150                 155                 160 


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
                165                 170                 175     


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
            180                 185                 190         


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Arg Gly Val Gln 
        195                 200                 205             


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
    210                 215                 220                 


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys 
225                 230                 235                 240 


Met Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
                245                 250                 255     


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
            260                 265                 270         


Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
        275                 280                 285             


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
    290                 295                 300                 


Asp Val Glu Leu Leu Lys Leu Glu 
305                 310         


<210>  32
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSDMD_WT_FLAG

<400>  32

Met Pro Ser Ala Phe Glu Lys Val Val Lys Asn Val Ile Lys Glu Val 
1               5                   10                  15      


Ser Gly Ser Arg Gly Asp Leu Ile Pro Val Asp Ser Leu Arg Asn Ser 
            20                  25                  30          


Thr Ser Phe Arg Pro Tyr Cys Leu Leu Asn Arg Lys Phe Ser Ser Ser 
        35                  40                  45              


Arg Phe Trp Lys Pro Arg Tyr Ser Cys Val Asn Leu Ser Ile Lys Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ala Pro Glu Pro Glu Pro Glu Cys Phe Gly Ser 
65                  70                  75                  80  


Phe Lys Val Ser Asp Val Val Asp Gly Asn Ile Gln Gly Arg Val Met 
                85                  90                  95      


Leu Ser Gly Met Gly Glu Gly Lys Ile Ser Gly Gly Ala Ala Val Ser 
            100                 105                 110         


Asp Ser Ser Ser Ala Ser Met Asn Val Cys Ile Leu Arg Val Thr Gln 
        115                 120                 125             


Lys Thr Trp Glu Thr Met Gln His Glu Arg His Leu Gln Gln Pro Glu 
    130                 135                 140                 


Asn Lys Ile Leu Gln Gln Leu Arg Ser Arg Gly Asp Asp Leu Phe Val 
145                 150                 155                 160 


Val Thr Glu Val Leu Gln Thr Lys Glu Glu Val Gln Ile Thr Glu Val 
                165                 170                 175     


His Ser Gln Glu Gly Ser Gly Gln Phe Thr Leu Pro Gly Ala Leu Cys 
            180                 185                 190         


Leu Lys Gly Glu Gly Lys Gly His Gln Ser Arg Lys Lys Met Val Thr 
        195                 200                 205             


Ile Pro Ala Gly Ser Ile Leu Ala Phe Arg Val Ala Gln Leu Leu Ile 
    210                 215                 220                 


Gly Ser Lys Trp Asp Ile Leu Leu Val Ser Asp Glu Lys Gln Arg Thr 
225                 230                 235                 240 


Phe Glu Pro Ser Ser Gly Asp Arg Lys Ala Val Gly Gln Arg His His 
                245                 250                 255     


Gly Leu Asn Val Leu Ala Ala Leu Cys Ser Ile Gly Lys Gln Leu Ser 
            260                 265                 270         


Leu Leu Ser Asp Gly Ile Asp Glu Glu Glu Leu Ile Glu Ala Ala Asp 
        275                 280                 285             


Phe Gln Gly Leu Tyr Ala Glu Val Lys Ala Cys Ser Ser Glu Leu Glu 
    290                 295                 300                 


Ser Leu Glu Met Glu Leu Arg Gln Gln Ile Leu Val Asn Ile Gly Lys 
305                 310                 315                 320 


Ile Leu Gln Asp Gln Pro Ser Met Glu Ala Leu Glu Ala Ser Leu Gly 
                325                 330                 335     


Gln Gly Leu Cys Ser Gly Gly Gln Val Glu Pro Leu Asp Gly Pro Ala 
            340                 345                 350         


Gly Cys Ile Leu Glu Cys Leu Val Leu Asp Ser Gly Glu Leu Val Pro 
        355                 360                 365             


Glu Leu Ala Ala Pro Ile Phe Tyr Leu Leu Gly Ala Leu Ala Val Leu 
    370                 375                 380                 


Ser Glu Thr Gln Gln Gln Leu Leu Ala Lys Ala Leu Glu Thr Thr Val 
385                 390                 395                 400 


Leu Ser Lys Gln Leu Glu Leu Val Lys His Val Leu Glu Gln Ser Thr 
                405                 410                 415     


Pro Trp Gln Glu Gln Ser Ser Val Ser Leu Pro Thr Val Leu Leu Gly 
            420                 425                 430         


Asp Cys Trp Asp Glu Lys Asn Pro Thr Trp Val Leu Leu Glu Glu Cys 
        435                 440                 445             


Gly Leu Arg Leu Gln Val Glu Ser Pro Gln Val His Trp Glu Pro Thr 
    450                 455                 460                 


Ser Leu Ile Pro Thr Ser Ala Leu Tyr Ala Ser Leu Phe Leu Leu Ser 
465                 470                 475                 480 


Ser Leu Gly Gln Lys Pro Cys Asp Tyr Lys Asp Asp Asp Asp Lys 
                485                 490                 495 


<210>  33
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1B_CALRSP

<400>  33

Met Gly Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala 
1               5                   10                  15      


Ala Ala Asp Pro Ala Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
            20                  25                  30          


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
        35                  40                  45              


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
    50                  55                  60                  


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
65                  70                  75                  80  


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
                85                  90                  95      


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
            100                 105                 110         


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
        115                 120                 125             


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
    130                 135                 140                 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
145                 150                 155                 160 


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
                165                 170             


<210>  34
<211>  178
<212>  PRT
<213>  Mus musculus

<400>  34

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Asn Phe Gly Arg Leu His Cys Thr Thr Ala Val 
            20                  25                  30          


Ile Arg Asn Ile Asn Asp Gln Val Leu Phe Val Asp Lys Arg Gln Pro 
        35                  40                  45              


Val Phe Glu Asp Met Thr Asp Ile Asp Gln Ser Ala Ser Glu Pro Gln 
    50                  55                  60                  


Thr Arg Leu Ile Ile Tyr Met Tyr Lys Asp Ser Glu Val Arg Gly Leu 
65                  70                  75                  80  


Ala Val Thr Leu Ser Val Lys Asp Ser Lys Met Ser Thr Leu Ser Cys 
                85                  90                  95      


Lys Asn Lys Ile Ile Ser Phe Glu Glu Met Asp Pro Pro Glu Asn Ile 
            100                 105                 110         


Asp Asp Ile Gln Ser Asp Leu Ile Phe Phe Gln Lys Arg Val Pro Gly 
        115                 120                 125             


His Asn Lys Met Glu Phe Glu Ser Ser Leu Tyr Glu Gly His Phe Leu 
    130                 135                 140                 


Ala Cys Gln Lys Glu Asp Asp Ala Phe Lys Leu Ile Leu Lys Lys Lys 
145                 150                 155                 160 


Asp Glu Asn Gly Asp Lys Ser Val Met Phe Thr Leu Thr Asn Leu His 
                165                 170                 175     


Gln Ser 
        


<210>  35
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2

<400>  35

Met Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
        35                  40                  45              


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    50                  55                  60                  


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
65                  70                  75                  80  


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Asp Ala Pro Val Arg 
            100                 105                 110         


Asp Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val 
        115                 120                 125             


Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met 
    130                 135                 140                 


Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu 
145                 150                 155                 160 


Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile 
                165                 170                 175     


Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu 
            180                 185                 190         


Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr 
        195                 200                 205             


Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys 
    210                 215                 220                 


Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala 
225                 230                 235                 240 


His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met 
                245                 250                 255     


Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln 
            260                 265                 270         


Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr 
        275                 280                 285             


Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln 
    290                 295                 300                 


Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
305                 310                 315             


<210>  36
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg 
            20                  25                  30          


Asp Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys 
        35                  40                  45              


Ala Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser 
    50                  55                  60                  


Met Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala 
65                  70                  75                  80  


Leu Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp 
                85                  90                  95      


Asp Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro 
            100                 105                 110         


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn 
        115                 120                 125             


Asn Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser 
    130                 135                 140                 


Thr Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly 
145                 150                 155                 160 


Gly Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
                165                 170                 


<210>  37
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Glu Val Pro Lys Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  38
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2_NTR

<400>  38

Met Gly Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys 
1               5                   10                  15      


Ser Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser 
            20                  25                  30          


Leu Phe Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser 
        35                  40                  45              


Cys Asp Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln 
    50                  55                  60                  


Pro Glu Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr 
65                  70                  75                  80  


Lys Arg Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Asp Val Pro 
                85                  90                  95      


Ile Arg Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys 
            100                 105                 110         


Gly Gly His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu 
        115                 120                 125             


Asp Gly Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu 
    130                 135                 140                 


Glu Lys Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro 
145                 150                 155                 160 


Ile Met Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn 
                165                 170                 175     


Thr Glu Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu 
            180                 185                 190         


Arg Glu Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val 
        195                 200                 205             


Lys Glu Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe 
    210                 215                 220                 


Ala Ala Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe 
225                 230                 235                 240 


Met Ser His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn 
                245                 250                 255     


Glu Val Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn 
            260                 265                 270         


Thr Leu Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile 
        275                 280                 285             


Gln Ala Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
    290                 295                 300             


<210>  39
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2_C305G

<400>  39

Met Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe 
        35                  40                  45              


Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp 
    50                  55                  60                  


Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu 
65                  70                  75                  80  


Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Asp Val Pro Ile Arg 
            100                 105                 110         


Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly 
        115                 120                 125             


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly 
    130                 135                 140                 


Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys 
145                 150                 155                 160 


Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met 
                165                 170                 175     


Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu 
            180                 185                 190         


Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu 
        195                 200                 205             


Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu 
    210                 215                 220                 


Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala 
225                 230                 235                 240 


Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser 
                245                 250                 255     


His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val 
            260                 265                 270         


Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu 
        275                 280                 285             


Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala 
    290                 295                 300                 


Gly Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
305                 310                 315         


<210>  40
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2_D108A

<400>  40

Met Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe 
        35                  40                  45              


Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp 
    50                  55                  60                  


Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu 
65                  70                  75                  80  


Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Ala Val Pro Ile Arg 
            100                 105                 110         


Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly 
        115                 120                 125             


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly 
    130                 135                 140                 


Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys 
145                 150                 155                 160 


Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met 
                165                 170                 175     


Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu 
            180                 185                 190         


Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu 
        195                 200                 205             


Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu 
    210                 215                 220                 


Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala 
225                 230                 235                 240 


Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser 
                245                 250                 255     


His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val 
            260                 265                 270         


Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu 
        275                 280                 285             


Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala 
    290                 295                 300                 


Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
305                 310                 315         


<210>  41
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2_D124A

<400>  41

Met Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe 
        35                  40                  45              


Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp 
    50                  55                  60                  


Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu 
65                  70                  75                  80  


Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Asp Val Pro Ile Arg 
            100                 105                 110         


Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Ala Ser Lys Gly Gly 
        115                 120                 125             


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly 
    130                 135                 140                 


Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys 
145                 150                 155                 160 


Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met 
                165                 170                 175     


Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu 
            180                 185                 190         


Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu 
        195                 200                 205             


Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu 
    210                 215                 220                 


Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala 
225                 230                 235                 240 


Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser 
                245                 250                 255     


His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val 
            260                 265                 270         


Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu 
        275                 280                 285             


Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala 
    290                 295                 300                 


Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
305                 310                 315         


<210>  42
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2_D143A

<400>  42

Met Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe 
        35                  40                  45              


Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp 
    50                  55                  60                  


Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu 
65                  70                  75                  80  


Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Asp Val Pro Ile Arg 
            100                 105                 110         


Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly 
        115                 120                 125             


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Ala Gly 
    130                 135                 140                 


Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys 
145                 150                 155                 160 


Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met 
                165                 170                 175     


Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu 
            180                 185                 190         


Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu 
        195                 200                 205             


Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu 
    210                 215                 220                 


Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala 
225                 230                 235                 240 


Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser 
                245                 250                 255     


His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val 
            260                 265                 270         


Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu 
        275                 280                 285             


Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala 
    290                 295                 300                 


Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
305                 310                 315         


<210>  43
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1_RV2_D108A_D124A_D143A

<400>  43

Met Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe 
        35                  40                  45              


Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp 
    50                  55                  60                  


Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu 
65                  70                  75                  80  


Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Leu Leu Val Cys Ala Val Pro Ile Arg 
            100                 105                 110         


Ala Pro Ser Ala Glu Thr Phe Val Ala Thr Glu Ala Ser Lys Gly Gly 
        115                 120                 125             


His Pro Ser Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Ala Gly 
    130                 135                 140                 


Thr Phe Pro Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys 
145                 150                 155                 160 


Ala Gln Lys Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met 
                165                 170                 175     


Asn Thr Thr Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu 
            180                 185                 190         


Phe Gln His Leu Ser Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu 
        195                 200                 205             


Met Lys Leu Leu Leu Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu 
    210                 215                 220                 


Asn Leu Thr Ala Leu Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala 
225                 230                 235                 240 


Cys Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser 
                245                 250                 255     


His Gly Ile Gln Glu Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val 
            260                 265                 270         


Ser Asp Ile Leu Lys Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu 
        275                 280                 285             


Lys Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala 
    290                 295                 300                 


Cys Arg Gly Glu Lys Gln Gly Val Val Leu Leu Lys Asp 
305                 310                 315         


<210>  44
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_C306G

<400>  44

Met Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
        35                  40                  45              


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    50                  55                  60                  


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
65                  70                  75                  80  


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Asp Ala Pro Val Arg 
            100                 105                 110         


Asp Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val 
        115                 120                 125             


Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met 
    130                 135                 140                 


Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu 
145                 150                 155                 160 


Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile 
                165                 170                 175     


Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu 
            180                 185                 190         


Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr 
        195                 200                 205             


Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys 
    210                 215                 220                 


Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala 
225                 230                 235                 240 


His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met 
                245                 250                 255     


Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln 
            260                 265                 270         


Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr 
        275                 280                 285             


Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln 
    290                 295                 300                 


Ala Gly Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
305                 310                 315             


<210>  45
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_D108A

<400>  45

Met Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
        35                  40                  45              


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    50                  55                  60                  


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
65                  70                  75                  80  


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Ala Ala Pro Val Arg 
            100                 105                 110         


Asp Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val 
        115                 120                 125             


Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met 
    130                 135                 140                 


Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu 
145                 150                 155                 160 


Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile 
                165                 170                 175     


Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu 
            180                 185                 190         


Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr 
        195                 200                 205             


Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys 
    210                 215                 220                 


Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala 
225                 230                 235                 240 


His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met 
                245                 250                 255     


Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln 
            260                 265                 270         


Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr 
        275                 280                 285             


Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln 
    290                 295                 300                 


Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
305                 310                 315             


<210>  46
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_D140A

<400>  46

Met Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
        35                  40                  45              


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    50                  55                  60                  


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
65                  70                  75                  80  


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Asp Ala Pro Val Arg 
            100                 105                 110         


Asp Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val 
        115                 120                 125             


Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Ala Asn Pro Ala Met 
    130                 135                 140                 


Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu 
145                 150                 155                 160 


Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile 
                165                 170                 175     


Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu 
            180                 185                 190         


Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr 
        195                 200                 205             


Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys 
    210                 215                 220                 


Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala 
225                 230                 235                 240 


His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met 
                245                 250                 255     


Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln 
            260                 265                 270         


Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr 
        275                 280                 285             


Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln 
    290                 295                 300                 


Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
305                 310                 315             


<210>  47
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_D124A

<400>  47

Met Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala 
1               5                   10                  15      


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
            20                  25                  30          


Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
        35                  40                  45              


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    50                  55                  60                  


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
65                  70                  75                  80  


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
                85                  90                  95      


Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Asp Ala Pro Val Arg 
            100                 105                 110         


Asp Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Ala Ser Gln Gly Val 
        115                 120                 125             


Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met 
    130                 135                 140                 


Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu 
145                 150                 155                 160 


Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile 
                165                 170                 175     


Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu 
            180                 185                 190         


Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr 
        195                 200                 205             


Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys 
    210                 215                 220                 


Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala 
225                 230                 235                 240 


His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met 
                245                 250                 255     


Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln 
            260                 265                 270         


Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr 
        275                 280                 285             


Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln 
    290                 295                 300                 


Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
305                 310                 315             


<210>  48
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_NTR2

<400>  48

Met Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys 
1               5                   10                  15      


Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val Ser Trp Arg 
            20                  25                  30          


His Pro Thr Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met 
        35                  40                  45              


Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val 
    50                  55                  60                  


Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Thr Thr 
65                  70                  75                  80  


Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu Phe Pro Gly His Ala 
                85                  90                  95      


Tyr Val His Asp Ala Pro Val Arg Asp Gln Thr Ser Gly Asn Tyr Leu 
            100                 105                 110         


Asn Met Gln Asp Ser Gln Gly Val Leu Ser Ser Phe Pro Ala Pro Gln 
        115                 120                 125             


Ala Val Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly 
    130                 135                 140                 


Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln 
145                 150                 155                 160 


Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg 
                165                 170                 175     


Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg 
            180                 185                 190         


Thr Gly Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn 
        195                 200                 205             


Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met 
    210                 215                 220                 


Thr Thr Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser 
225                 230                 235                 240 


Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile 
                245                 250                 255     


Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn 
            260                 265                 270         


Ala Ile Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp 
        275                 280                 285             


Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly 
    290                 295                 300                 


Val Val Trp Phe Lys Asp 
305                 310 


<210>  49
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_NTR

<400>  49

Met Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys 
1               5                   10                  15      


Ser Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser 
            20                  25                  30          


Val Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser 
        35                  40                  45              


Cys Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln 
    50                  55                  60                  


Pro Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr 
65                  70                  75                  80  


Arg Cys Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Asp Ala Pro 
                85                  90                  95      


Val Arg Asp Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Asp Ser Gln 
            100                 105                 110         


Gly Val Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp Asn Pro 
        115                 120                 125             


Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser 
    130                 135                 140                 


Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr 
145                 150                 155                 160 


Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys 
                165                 170                 175     


Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp 
            180                 185                 190         


Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp 
        195                 200                 205             


Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala 
    210                 215                 220                 


Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val 
225                 230                 235                 240 


Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser 
                245                 250                 255     


Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu 
            260                 265                 270         


Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile 
        275                 280                 285             


Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
    290                 295                 300                 


<210>  50
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_NTR_GSL

<400>  50

Met Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys 
1               5                   10                  15      


Ser Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser 
            20                  25                  30          


Val Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser 
        35                  40                  45              


Cys Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln 
    50                  55                  60                  


Pro Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr 
65                  70                  75                  80  


Arg Cys Phe Tyr Leu Phe Pro Gly His Gly Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val 
            100                 105                 110         


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
        115                 120                 125             


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala 
    130                 135                 140                 


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly 
145                 150                 155                 160 


Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly 
                165                 170                 175     


Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr 
            180                 185                 190         


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser 
        195                 200                 205             


Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
    210                 215                 220                 


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
225                 230                 235                 240 


Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
                245                 250                 255     


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
            260                 265                 270         


Trp Phe Lys Asp 
        275     


<210>  51
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_RV2_NTR_CCS

<400>  51

Met Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys 
1               5                   10                  15      


Ser Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser 
            20                  25                  30          


Val Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser 
        35                  40                  45              


Cys Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln 
    50                  55                  60                  


Pro Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr 
65                  70                  75                  80  


Arg Cys Phe Tyr Leu Phe Pro Gly His Ala Tyr Val His Asp Ala Pro 
                85                  90                  95      


Val Arg Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val 
            100                 105                 110         


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
        115                 120                 125             


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala 
    130                 135                 140                 


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly 
145                 150                 155                 160 


Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly 
                165                 170                 175     


Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr 
            180                 185                 190         


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser 
        195                 200                 205             


Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
    210                 215                 220                 


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
225                 230                 235                 240 


Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
                245                 250                 255     


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
            260                 265                 270         


Trp Phe Lys Asp 
        275     


<210>  52
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Asp Gln Thr Ser Gly 
                85                  90                  95      


Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val Leu Ser Ser Phe Pro 
            100                 105                 110         


Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly 
        115                 120                 125             


Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile 
    130                 135                 140                 


Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser 
145                 150                 155                 160 


Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile 
                165                 170                 175     


Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu 
            180                 185                 190         


Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala 
        195                 200                 205             


Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg Pro Glu His 
    210                 215                 220                 


Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Arg 
225                 230                 235                 240 


Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu 
                245                 250                 255     


Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser 
            260                 265                 270         


Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp 
        275                 280                 285             


Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn 
    290                 295                 300                 


Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys 
305                 310                 315                 320 


Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp 
                325                 330                 335     


Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe Ile Gly Arg 
            340                 345                 350         


Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu 
        355                 360                 365             


Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala 
    370                 375                 380                 


Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu 
385                 390                 395                 400 


Phe Pro Gly His 
                


<210>  53
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGSDMD_WT_FLAG

<400>  53

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         


Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             


Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 


Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 


Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     


Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         


Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             


Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 


Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 


Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     


Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         


Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             


Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 


Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Gln Glu Pro His Asp Tyr Lys Asp Asp Asp Asp Lys 
                485                 490         


<210>  54
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_CARD

<400>  54

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Asp 
                85                  90          


<210>  55
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_CDL

<400>  55

Gln Thr Ser Gly Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val Leu 
1               5                   10                  15      


Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp 
            20                  25          


<210>  56
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_p20

<400>  56

Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu 
1               5                   10                  15      


Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu 
            20                  25                  30          


Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile 
        35                  40                  45              


Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu 
    50                  55                  60                  


Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser 
65                  70                  75                  80  


Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu 
                85                  90                  95      


Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe 
            100                 105                 110         


Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys 
        115                 120                 125             


His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn 
    130                 135                 140                 


Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val 
145                 150                 155                 160 


Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe 
                165                 170                 175     


Lys Asp 
        


<210>  57
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_IDL

<400>  57

Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe 
1               5                   10                  15      


Glu Asp Asp 
            


<210>  58
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCASP1_p10

<400>  58

Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser 
1               5                   10                  15      


Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val 
            20                  25                  30          


Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys 
        35                  40                  45              


Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro 
    50                  55                  60                  


Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg 
65                  70                  75                  80  


Cys Phe Tyr Leu Phe Pro Gly His 
                85              


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding sequence

<400>  59

Gly Gly Val Ala Asp Leu Ile Lys Lys Phe Glu Ser Ile Ser Lys Glu 
1               5                   10                  15      


Glu 
    


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDL sequence

<400>  60

Ser Glu Glu Asp Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp 
1               5                   10                  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inter-domain linker

<400>  61

Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp 
1               5                   10                  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  63

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  64

Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser 
1               5                   10                  15  


<210>  65
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  65

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa

<400>  66

Ala Tyr Val His Asp Ala Pro Val Arg 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  67

Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   


<210>  68
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  68

Phe Pro Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr Ser 
1               5                   10                  15      


Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln 
            20                  25                  30          


Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys 
        35                  40                  45              


Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn 
    50                  55                  60  


<210>  69
<211>  59
<212>  PRT
<213>  Mus musculus

<400>  69

Ser Ser Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly Thr Phe Pro 
1               5                   10                  15      


Gly Leu Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys Ala Gln Lys 
            20                  25                  30          


Leu Trp Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met Asn Thr Thr 
        35                  40                  45              


Thr Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn 
    50                  55                  


<210>  70
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  70

Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro Pro Glu Ser 
1               5                   10                  15      


Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro His Glu Glu Phe Leu 
            20                  25                  30          


Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile Lys Glu Arg 
        35                  40                  45              


Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn 
    50                  55                  60  


<210>  71
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  71

His His Gly Glu Ala Asn Leu Glu Met Glu Glu Pro Glu Glu Ser Leu 
1               5                   10                  15      


Asn Thr Leu Lys Leu Cys Ser Pro Glu Glu Phe Thr Arg Leu Cys Arg 
            20                  25                  30          


Glu Lys Thr Gln Glu Ile Tyr Pro Ile Lys Glu Ala Asn Gly Arg Thr 
        35                  40                  45              


Arg Lys Ala Leu Ile Ile Cys Asn 
    50                  55      


<210>  72
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  72

Thr Ser Val Lys Pro Leu Leu Gln Ile Glu Ala Gly Pro Pro Glu Ser 
1               5                   10                  15      


Ala Glu Ser Thr Asn Ile Leu Lys Leu Cys Pro Arg Glu Glu Phe Leu 
            20                  25                  30          


Arg Leu Cys Lys Lys Asn His Asp Glu Ile Tyr Pro Ile Lys Lys Arg 
        35                  40                  45              


Glu Asp Arg Arg Arg Leu Ala Leu Ile Ile Cys Asn 
    50                  55                  60  


<210>  73
<211>  60
<212>  PRT
<213>  Mus musculus

<400>  73

Ala His Glu Ser His Leu Met Leu Thr Ala Pro His Gly Leu Gln Ser 
1               5                   10                  15      


Ser Glu Val Gln Asp Thr Leu Lys Leu Cys Pro Arg Asp Gln Phe Cys 
            20                  25                  30          


Lys Ile Lys Thr Glu Arg Ala Lys Glu Ile Tyr Pro Val Met Glu Lys 
        35                  40                  45              


Glu Gly Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn 
    50                  55                  60  


<210>  74
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  74

Val Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser 
1               5                   10                  15      


Cys Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln 
            20                  25                  30          


Pro Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr 
        35                  40                  45              


Arg Cys Phe Tyr Leu Phe Pro Gly His 
    50                  55          


<210>  75
<211>  57
<212>  PRT
<213>  Mus musculus

<400>  75

Leu Phe Ile Glu Ser Leu Ile Lys His Met Lys Glu Tyr Ala Trp Ser 
1               5                   10                  15      


Cys Asp Leu Glu Asp Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln 
            20                  25                  30          


Pro Glu Phe Arg Leu Gln Met Pro Thr Ala Asp Arg Val Thr Leu Thr 
        35                  40                  45              


Lys Arg Phe Tyr Leu Phe Pro Gly His 
    50                  55          


<210>  76
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  76

Ile Phe Ile Thr Gln Leu Ile Thr Cys Phe Gln Lys Tyr Ser Trp Cys 
1               5                   10                  15      


Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe Glu Thr 
            20                  25                  30          


Pro Arg Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Leu Ser Met Thr 
        35                  40                  45              


Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    50                  55          


<210>  77
<211>  57
<212>  PRT
<213>  Mus musculus

<400>  77

Tyr Phe Ile Thr Arg Leu Ile Ser Cys Phe Arg Lys His Ala Cys Ser 
1               5                   10                  15      


Cys His Leu Phe Asp Ile Phe Leu Lys Val Gln Gln Ser Phe Glu Lys 
            20                  25                  30          


Ala Ser Ile His Ser Gln Met Pro Thr Ile Asp Arg Ala Thr Leu Thr 
        35                  40                  45              


Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    50                  55          


<210>  78
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  78

Ile Phe Ile Thr Glu Leu Ile Thr Cys Phe Gln Lys Tyr Ser Cys Cys 
1               5                   10                  15      


Cys His Leu Met Glu Ile Phe Arg Lys Val Gln Lys Ser Phe Glu Val 
            20                  25                  30          


Pro Gln Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Ala Thr Leu Thr 
        35                  40                  45              


Arg Asp Phe Tyr Leu Phe Pro Gly Asn 
    50                  55          


<210>  79
<211>  57
<212>  PRT
<213>  Mus musculus

<400>  79

Leu Phe Ile Ser Lys Leu Ile Asp Cys Phe Lys Lys Tyr Cys Trp Cys 
1               5                   10                  15      


Tyr His Leu Glu Glu Ile Phe Arg Lys Val Gln His Ser Phe Glu Val 
            20                  25                  30          


Pro Gly Glu Leu Thr Gln Met Pro Thr Ile Glu Arg Val Ser Met Thr 
        35                  40                  45              


Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    50                  55          


