                         SEQUENCE LISTING

<110>  QUEEN MARY UNIVERSITY OF LONDON
 
<120>  TREATMENT AND DIAGNOSIS OF MENTAL DISORDERS

<130>  007647654

<140>  PCT/EP2020/059466
<141>  2020-04-02

<150>  GB 1904717.4
<151>  2019-04-03

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  198
<212>  PRT
<213>  Homo sapiens TDRP

<400>  1

Met Trp Lys Leu Gly Arg Gly Arg Val Leu Leu Asp Glu Pro Pro Glu 
1               5                   10                  15      


Glu Glu Asp Gly Leu Arg Gly Gly Pro Pro Pro Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gln Ala Gln Val Gln Gly Ala Ser Phe Arg Gly Trp Lys Glu Val 
        35                  40                  45              


Thr Ser Leu Phe Asn Lys Asp Asp Glu Gln His Leu Leu Glu Arg Cys 
    50                  55                  60                  


Lys Ser Pro Lys Ser Lys Gly Thr Asn Leu Arg Leu Lys Glu Glu Leu 
65                  70                  75                  80  


Lys Ala Glu Lys Lys Ser Gly Phe Trp Asp Asn Leu Val Leu Lys Gln 
                85                  90                  95      


Asn Ile Gln Ser Lys Lys Pro Asp Glu Ile Glu Gly Trp Glu Pro Pro 
            100                 105                 110         


Lys Leu Ala Leu Glu Asp Ile Ser Ala Asp Pro Glu Asp Thr Val Gly 
        115                 120                 125             


Gly His Pro Ser Trp Ser Gly Trp Glu Asp Asp Ala Lys Gly Ser Thr 
    130                 135                 140                 


Lys Tyr Thr Ser Leu Ala Ser Ser Ala Asn Ser Ser Arg Trp Ser Leu 
145                 150                 155                 160 


Arg Ala Ala Gly Arg Leu Ile Lys Glu Val Trp Ile Asn Phe Ser Gln 
                165                 170                 175     


Leu Ile Ile Ser Phe Arg Lys His Cys Leu Ala His Tyr Arg Glu Leu 
            180                 185                 190         


Arg Leu Cys Ile Lys Tyr 
        195             


<210>  2
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TDRP binding sequence

<400>  2

Met Trp Lys Leu Gly Arg Gly Arg Val Leu Leu Asp Glu Pro Pro Glu 
1               5                   10                  15      


Glu Glu Asp Gly Leu Arg Gly Gly Pro Pro Pro Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gln Ala Gln Val Gln Gly Ala Ser Phe Arg Gly Trp Lys Glu Val 
        35                  40                  45              


Thr Ser Leu Phe Asn Lys Asp Asp Glu Gln His Leu Leu Glu Arg Cys 
    50                  55                  60                  


Lys Ser Pro Lys Ser Lys Gly Thr Asn Leu Arg Leu Lys Glu Glu Leu 
65                  70                  75                  80  


Lys Ala Glu Lys Lys Ser Gly Phe Trp Asp Asn Leu Val Leu Lys Gln 
                85                  90                  95      


Asn Ile Gln Ser Lys Lys Pro Asp Glu Ile Glu Gly Trp Glu Pro Pro 
            100                 105                 110         


Lys Leu Ala Leu Glu Asp Ile Ser Ala Asp Pro Glu Asp Thr Val Gly 
        115                 120                 125             


Gly His Pro Ser Trp Ser Gly Trp Glu Asp Asp Ala Lys Gly Ser Thr 
    130                 135                 140                 


Lys Tyr Thr Ser Leu Ala Ser Ser Ala Asn Ser Ser Arg Trp Ser Leu 
145                 150                 155                 160 


Arg Ala Ala Gly Arg Leu Val Ser Ile Arg Arg Gln Ser Lys Gly His 
                165                 170                 175     


Leu Thr Asp Ser Pro Glu Glu Ala Glu 
            180                 185 


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VHCDR1

<400>  3

Asn Val Ala Met Tyr 
1               5   


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VHCDR2

<400>  4

Arg Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VHCDR3

<400>  5

Trp Val Ile Val Pro Leu Tyr Phe Asp Tyr 
1               5                   10  


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VLCDR1

<400>  6

Arg Ser Ser Lys Ser Leu Leu Ser Ser Lys Gly Ile Thr Ser Leu Tyr 
1               5                   10                  15      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VLCDR1

<400>  7

Lys Ser Leu Leu Ser Ser Lys Gly Ile Thr Ser 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VLCDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Xaa Met Ser Asn Leu Ala Ser 
1               5           


<210>  9
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VLCDR2

<400>  9

Gln Met Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VLCDR3

<400>  10

Gly His Arg Leu Gln Thr Pro Phe Thr 
1               5                   


<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VH

<400>  11

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asn Val 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Trp Val Ile Val Pro Leu Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1B10 VH coding

<400>  12
gcggtgcagc tggttgagtc tggtggagga ttggtgcagc ctgaggagtc attgaaaatc       60

tcatgtgcag cttctggaat caccttcagt aatgttgcca tgtactgggt ccgccaggct      120

ccaggaaagg gtctggaatg ggttgctcgc ataagaagta aagctaataa ttatgcaaca      180

tattatgctg attcagtgaa aggcagattc accatctcca gagatgattc aaaaagcatg      240

gtctacctac aaatggataa cttgaaaact gaggacacag ccatgtacta ttgttcagca      300

tgggttatag tgcccctata ttttgattac tggggccaag gagtcatggt cacagtctcc      360

tca                                                                    363


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VL)


<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa = independently any amino acid; preferably Q

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa = independently any amino acid; preferably S

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa = independently any amino acid; preferably K

<400>  13

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Val Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Ser Ser 
            20                  25                  30          


Lys Gly Ile Thr Ser Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Lys Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Xaa Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Xaa Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Xaa Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly His Arg 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B10 VL

<400>  14

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Val Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Ser Ser 
            20                  25                  30          


Lys Gly Ile Thr Ser Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Lys Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Lys Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly His Arg 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1B10 VL coding


<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (205)..(205)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (245)..(245)
<223>  n is a, c, g, or t

<400>  15
gatattgtga tgactcaagc tccactctct gtatctgtca ctcctggaga gtcagcttcc       60

atctcctgca gntctagtaa gagtctgcta agtagtaagg gcatcacttc cttgtattgg      120

taccttcaga ggccaggaaa gtctcctcag ctcctgatat atcngatgtc caaccttgcc      180

tcaggagttc cagacaggtt tagtngcagt gggtcagaaa ccgattttac actgaaaatc      240

agtanggtgg aggctgagga tgttggtgtt tattactgtg gacatcgtct acaaactcca      300

ttcacgttcg gctcagggac gaaattggaa ataaaa                                336


<210>  16
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1B10 VL coding

<400>  16
gatattgtga tgactcaagc tccactctct gtatctgtca ctcctggaga gtcagcttcc       60

atctcctgca ggtctagtaa gagtctgcta agtagtaagg gcatcacttc cttgtattgg      120

taccttcaga ggccaggaaa gtctcctcag ctcctgatat atcagatgtc caaccttgcc      180

tcaggagttc cagacaggtt tagtagcagt gggtcagaaa ccgattttac actgaaaatc      240

agtaaggtgg aggctgagga tgttggtgtt tattactgtg gacatcgtct acaaactcca      300

ttcacgttcg gctcagggac gaaattggaa ataaaa                                336


<210>  17
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2610019F03Rik (aa 2-190)

<400>  17

Trp Lys Leu Ser Arg Ser Arg Val Leu Leu Asp Glu Pro Pro Glu Glu 
1               5                   10                  15      


Glu Asp Val Leu Arg Gly Ala Pro Pro Ala Ser Ala Ala Ala Pro Ala 
            20                  25                  30          


Ser Val Arg Ala Arg Val Gly Ala Gln Gly Ala Ser Leu Arg Gly Trp 
        35                  40                  45              


Lys Glu Ala Thr Ser Leu Phe Asn Lys Asp Asp Glu Glu His Leu Leu 
    50                  55                  60                  


Glu Thr Ser Arg Ser Pro Lys Ser Lys Gly Thr Asn Gln Arg Leu Arg 
65                  70                  75                  80  


Glu Glu Leu Lys Ala Glu Lys Lys Ser Gly Phe Trp Asp Ala Leu Val 
                85                  90                  95      


Leu Lys Gln Asn Ala Gln Pro Lys Lys Pro Asp Gln Ile Glu Gly Trp 
            100                 105                 110         


Glu Pro Pro Lys Leu Thr Ala Glu Asp Val Val Ala Asp His Thr Glu 
        115                 120                 125             


Asp Asp Arg Ser Gly Cys Pro Pro Trp Ser Ala Trp Glu Asp Asp Thr 
    130                 135                 140                 


Lys Gly Ser Thr Lys Tyr Thr Ser Leu Ala Asn Ser Ala Ser Ser Ser 
145                 150                 155                 160 


Arg Trp Ser Leu Arg Ser Ala Gly Lys Leu Val Ser Ile Arg Arg Gln 
                165                 170                 175     


Ser Lys Gly His Leu Thr Glu Thr Cys Glu Glu Gly Glu 
            180                 185                 


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VHCDR1

<400>  18

Gly Phe Thr Phe Ser Asp Tyr Asn 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VHCDR2

<400>  19

Ile Ile Tyr Asp Gly Asp Arg Thr 
1               5               


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VHCDR3

<400>  20

Ala Thr Gly Leu Ala Tyr 
1               5       


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11C4 VLCDR1

<400>  21

Gln Ser Leu Leu Tyr Ser Glu Asn Lys Lys Asn Tyr 
1               5                   10          


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VLCDR2

<400>  22

Trp Ala Ser 
1           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VLCDR3

<400>  23

Gln Gln Tyr Tyr Asn Phe Pro Ser Thr 
1               5                   


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VH

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Lys Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ile Tyr Asp Gly Asp Arg Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  25
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1C4 VH coding

<400>  25
atggacatca ggctcagctt ggttttcctt gtccttttca taaaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg cggaggctta gtacagcctg gaaggtccct gaaactctcc      120

tgtgcagcct caggattcac tttcagtgac tataacatgg cctgggtccg ccaggctcca      180

aagaggggtc tggagtgggt cgcaaccatt atttatgatg gtgataggac ttactatcga      240

gactccgtga agggccgatt cactatctcc agagataaag caaaaaccac cctatatttg      300

caaatggaca gtctgaggtc tgaggacacg gccacttatt actgtgcaac agggcttgct      360

tactggggcc aaggcactct ggtcactgtc tcttcag                               397


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4 VL

<400>  26

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Gln Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Glu Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Phe Pro Ser Thr Phe Gly Thr Gly Thr Thr Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  27
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1C4 VL coding

<400>  27
atggaatcac agacccaggt cctcatgtcc ctgctgctct gggtatctgg tacctgtggg       60

gacattgtga tgacccagac tccatcctcc caggctgtgt caccagggga gaaggtcact      120

atgagctgca agtccagtca gagtctttta tacagtgaaa acaaaaagaa ctacttggcc      180

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      240

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactctgacc      300

atcagcagtg tgcaggcaga agacctggct gtttattact gccagcaata ctataacttt      360

ccgagcacgt ttggaactgg gaccacgctg gagctgaaac                            400


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AnxA1tg primer

<400>  28
gtatggaatc tctctttgcc aagc                                              24


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AnxA1tg primer

<400>  29
achgatatgc acatcaggag gg                                                22


