                         SEQUENCE LISTING

<110>  INSTITUT CURIE
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
 
<120>  INTERLEUKIN-2 VARIANTS WITH MODIFIED BIOLOGICAL ACTIVITY

<130>  BEP190944 EP 

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  homo sapiens

<400>  1

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  2
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-WT

<400>  2

Ala Pro Thr Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  3
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-V1

<400>  3

Ala Pro Thr Ser Ser Thr Lys Glu Thr Gln Glu Gln Leu Glu Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu Gln Leu Ile Leu Lys Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Asn Asn Ile Asn Lys Ile Val Leu Lys Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Lys Arg Trp Ile Ala Phe Cys Gln Lys Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  4
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-V2

<400>  4

Ala Pro Thr Ser Ser Thr Lys Glu Thr Gln Glu Gln Leu Glu Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu Gln Leu Ile Leu Lys Gly Ile Asn Asn Pro Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Gln 
        35                  40                  45              


Ala Thr Ser Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Glu 
65                  70                  75                  80  


Pro Arg Asn Leu Ile Asn Asn Ile Asn Lys Ile Val Leu Lys Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Lys Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
        115                 120                 125             


Ser Arg Ser Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  5
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-V3

<400>  5

Ala Pro Thr Ser Ser Thr Lys Glu Thr Gln Glu Gln Leu Glu Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu Gln Leu Ile Leu Lys Gly Ile Asn Asn Pro Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Gln 
        35                  40                  45              


Ala Thr Ser Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Glu 
65                  70                  75                  80  


Pro Arg Asn Leu Ile Asn Asn Ile Asn Lys Ile Val Leu Lys Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        115                 120                 125             


Ser Arg Ser Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  6
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-V4

<400>  6

Ala Pro Thr Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Pro Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  7
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-V5

<400>  7

Ala Pro Thr Ser Ser Thr Lys Glu Thr Gln Glu Gln Leu Glu Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu Gln Leu Ile Leu Lys Gly Ile Asn Asn Pro Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Asn Asn Ile Asn Lys Ile Val Leu Lys Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Lys Arg Trp Ile Ala Phe Cys Gln Lys Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  8
<211>  171
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide IL2-V6

<400>  8

Ala Pro Thr Ser Ser Thr Lys Glu Thr Gln Glu Gln Leu Glu Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu Gln Leu Ile Leu Lys Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Gln 
        35                  40                  45              


Ala Thr Ser Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Glu 
65                  70                  75                  80  


Pro Arg Asn Leu Ile Asn Asn Ile Asn Lys Ile Val Leu Lys Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Lys Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
        115                 120                 125             


Ser Arg Ser Thr Gly Ala Leu Val Pro Arg Gly Ser Ser Ala Trp Ser 
    130                 135                 140                 


His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                165                 170     


<210>  9
<211>  531
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding IL2-v1

<400>  9
accggtgccc ccaccagctc cacaaaggag acccaggagc agctggagag gctgctgagg       60

gacctgcagc tgatcctgaa gggcatcaac aattacaaga acccaaagct gacacggatg      120

ctgaccttca agttttatat gcccaagaag gccacagagc tgaagcacct gcagtgcctg      180

gaggaggagc tgaagcctct ggaggaggtg ctgaacctgg cccagtccaa gaatttccac      240

ctgcggccaa gagacctgat caacaatatc aataagatcg tgctgaagct gaagggctct      300

gagaccacct tcatgtgcga gtacgccgat gagaccgcca caatcgtgga gttcctgaag      360

cggtggatcg ccttttgtca gaagatcatc tctaccctga caggcgccct ggtgcccagg      420

ggctctagcg cctggagcca ccctcagttc gagaagggag gaggaagcgg aggaggatcc      480

ggaggcggct ccgcctggtc tcaccctcag tttgagaagt agtaactcga g               531


<210>  10
<211>  531
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding IL2-v2

<400>  10
accggtgccc ccaccagctc cacaaaggag acccaggagc agctggagcg gctgctgaga       60

gacctgcagc tgatcctgaa gggcatcaac aatcccaaga accctaagct gacacggatg      120

ctgaccttca agttttacat gcctaagcag gccacaagcc tgaagcacct gcagtgcctg      180

gaggaggagc tgaagcctct ggaggaggtg ctgaacctgg cccagtccaa gaatttccac      240

ctggagccac ggaacctgat caacaatatc aataagatcg tgctgaagct gaagggctct      300

gagaccacct tcatgtgcga gtatgccgat gagaccgcca caatcgtgga gttcctgaag      360

aggtggatcg ccttttgtca gtccatcatc tccaggtcta ccggcgccct ggtgccacgc      420

ggctctagcg cctggtctca cccacagttc gagaagggag gaggatctgg aggaggaagc      480

ggaggcggca gcgcctggtc ccacccccag tttgagaagt agtaactcga g               531


<210>  11
<211>  531
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding IL2-v3

<400>  11
accggtgccc ccaccagctc cacaaaggag acccaggagc agctggagcg gctgctgaga       60

gacctgcagc tgatcctgaa gggcatcaac aatcccaaga accctaagct gacacggatg      120

ctgaccttca agttttacat gcctaagcag gccacaagcc tgaagcacct gcagtgcctg      180

gaggaggagc tgaagcctct ggaggaggtg ctgaacctgg cccagtccaa gaatttccac      240

ctggagccac ggaacctgat caacaatatc aataagatcg tgctgaagct gaagggctct      300

gagaccacct tcatgtgcga gtatgccgat gagaccgcca caatcgtgga gttcctgaac      360

aggtggatca ccttttgtca gtccatcatc tccaggtcta ccggcgccct ggtgccacgc      420

ggctctagcg cctggtctca cccacagttc gagaagggag gaggatctgg aggaggaagc      480

ggaggcggca gcgcctggtc ccacccccag tttgagaagt agtaactcga g               531


<210>  12
<211>  531
<212>  DNA
<213>  synthetic polynucleotide encoding IL2-v4

<400>  12
accggtgccc ccaccagctc cacaaagaag acccagctgc agctggagca cctgctgctg       60

gacctgcaga tgatcctgaa cggcatcaac aatcccaaga atccaaagct gacacggatg      120

ctgaccttca agttttatat gcccaagaag gccacagagc tgaagcacct gcagtgcctg      180

gaggaggagc tgaagcctct ggaggaggtg ctgaacctgg cccagtccaa gaatttccac      240

ctgcggccaa gagacctgat ctctaacatc aatgtgatcg tgctggagct gaagggcagc      300

gagaccacct tcatgtgcga gtacgccgat gagaccgcca caatcgtgga gttcctgaac      360

aggtggatca ccttttgtca gtccatcatc tctaccctga caggcgccct ggtgccccgc      420

ggctctagcg cctggtccca ccctcagttc gagaagggag gaggatctgg aggaggaagc      480

ggaggcggca gcgcctggag ccatcctcag tttgagaagt agtaactcga g               531


<210>  13
<211>  531
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding IL2-v5

<400>  13
accggtgccc ccaccagctc cacaaaggag acccaggagc agctggagag gctgctgagg       60

gacctgcagc tgatcctgaa gggcatcaac aatcccaaga acccaaagct gacacggatg      120

ctgaccttca agttttatat gcccaagaag gccacagagc tgaagcacct gcagtgcctg      180

gaggaggagc tgaagcctct ggaggaggtg ctgaacctgg cccagtccaa gaatttccac      240

ctgcggccaa gagacctgat caacaatatc aataagatcg tgctgaagct gaagggctct      300

gagaccacct tcatgtgcga gtacgccgat gagaccgcca caatcgtgga gttcctgaag      360

cggtggatcg ccttttgtca gaagatcatc tctaccctga caggcgccct ggtgcccagg      420

ggctctagcg cctggagcca ccctcagttc gagaagggag gaggaagcgg aggaggatcc      480

ggaggcggct ccgcctggtc tcaccctcag tttgagaagt agtaactcga g               531


<210>  14
<211>  531
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding IL-2v6

<400>  14
accggtgccc ccaccagctc cacaaaggag acccaggagc agctggagcg gctgctgaga       60

gacctgcagc tgatcctgaa gggcatcaac aattacaaga accctaagct gacacggatg      120

ctgaccttca agttttacat gcctaagcag gccacaagcc tgaagcacct gcagtgcctg      180

gaggaggagc tgaagcctct ggaggaggtg ctgaacctgg cccagtccaa gaatttccac      240

ctggagccac ggaacctgat caacaatatc aataagatcg tgctgaagct gaagggctct      300

gagaccacct tcatgtgcga gtatgccgat gagaccgcca caatcgtgga gttcctgaag      360

aggtggatcg ccttttgtca gtccatcatc tccaggtcta ccggcgccct ggtgccacgc      420

ggctctagcg cctggtctca cccacagttc gagaagggag gaggatctgg aggaggaagc      480

ggaggcggca gcgcctggtc ccacccccag tttgagaagt agtaactcga g               531


<210>  15
<211>  153
<212>  PRT
<213>  Hylobates lar

<400>  15

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  16
<211>  154
<212>  PRT
<213>  Macaca mulatta

<400>  16

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Asp Thr Lys Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Leu Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  17
<211>  154
<212>  PRT
<213>  Macaca nemestrina

<400>  17

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Asp Thr Lys Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Leu Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  18
<211>  154
<212>  PRT
<213>  Macaca fascicularis

<400>  18

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Arg His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Ser Phe His Leu Arg Asp Thr Lys Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Leu Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  19
<211>  154
<212>  PRT
<213>  Cercocebus torquatus

<400>  19

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Arg Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Asp Thr Lys Asp Leu Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Leu Met Cys Glu Tyr 
        115                 120                 125             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  20
<211>  154
<212>  PRT
<213>  Aotus vociferans

<400>  20

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Ile Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Leu Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Asp Thr Arg Asp Ile Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Leu Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Thr Cys Glu Tyr 
        115                 120                 125             


Asp Asp Asp Thr Ala Thr Ile Ile Glu Phe Leu Asn Gly Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  21
<211>  154
<212>  PRT
<213>  Papio hamadryas

<400>  21

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Ile Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Leu Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Asp Thr Arg Asp Ile Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Leu Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Thr Cys Glu Tyr 
        115                 120                 125             


Asp Asp Asp Thr Ala Thr Ile Ile Glu Phe Leu Asn Gly Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 


<210>  22
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  22

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Pro Thr Ser Ser Pro Thr Ser 
            20                  25                  30          


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  23
<211>  155
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Ala Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Pro Ala Lys Glu Thr Gln Gln 
            20                  25                  30          


His Leu Glu Gln Leu Leu Leu Asp Leu Gln Val Leu Leu Arg Gly Ile 
        35                  40                  45              


Asp Asn Tyr Lys Asn Leu Lys Leu Pro Met Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Asn Glu Leu Gly Ala Leu Gln Arg Val Leu Asp Leu Thr Gln Ser Lys 
                85                  90                  95      


Ser Phe His Leu Glu Asp Ala Gly Asn Phe Ile Ser Asn Ile Arg Val 
            100                 105                 110         


Thr Val Val Lys Leu Lys Gly Ser Glu Asn Lys Phe Glu Cys Gln Phe 
        115                 120                 125             


Asp Asp Glu Pro Ala Thr Val Val Glu Phe Leu Arg Arg Trp Ile Ala 
    130                 135                 140                 


Ile Cys Gln Ser Ile Ile Ser Thr Met Thr Gln 
145                 150                 155 


<210>  24
<211>  155
<212>  PRT
<213>  Meriones unguiculatus

<400>  24

Met Tyr Ser Arg Gln Leu Ala Ser Cys Val Ala Leu Ala Leu Val Leu 
1               5                   10                  15      


Leu Ala Asn Ser Ala Pro Thr Ser Ser Pro Ala Lys Glu Ala Gln Gln 
            20                  25                  30          


Tyr Leu Glu Gln Leu Leu Leu Asp Leu Gln Gln Leu Leu Arg Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Pro Met Leu Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Arg Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Gly Pro Leu His Asp Val Leu Asn Leu Val Gln Ser Lys 
                85                  90                  95      


Asn Leu Tyr Leu Glu Asp Ala Gly Asn Phe Ile Ser Asn Ile Arg Val 
            100                 105                 110         


Thr Val Met Lys Leu Lys Gly Ser Glu Asn Thr Leu Asn Cys Glu Phe 
        115                 120                 125             


Asp Asp Glu Thr Val Thr Val Val Glu Phe Leu Ser Arg Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ala Ile Ser Thr Met Thr Gln 
145                 150                 155 


<210>  25
<211>  152
<212>  PRT
<213>  Cavia porcellus

<400>  25

Met Tyr Lys Thr Leu Leu Leu Ser Cys Leu Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Leu Thr Ser Ser Ala Pro Thr Ser Ser Ser Pro Lys Gln Thr Gln Asp 
            20                  25                  30          


Arg Leu Glu Leu Leu Leu Arg Asp Leu Gln Thr Leu Leu Glu Gly Val 
        35                  40                  45              


Thr Ser Asn Pro Arg Leu Pro Lys Met Leu Lys Leu Lys Leu Tyr Pro 
    50                  55                  60                  


Pro Lys Met Val Ser Glu Leu Gln His Leu Gln Cys Leu Glu Glu Glu 
65                  70                  75                  80  


Leu Arg Ala Val Glu Gln Val Leu Asn Leu Ala Glu His Lys Asn Phe 
                85                  90                  95      


Pro Leu Ile His Thr Lys Asp Phe Ile Ser Asn Ile Asn Val Thr Val 
            100                 105                 110         


Leu Ser Leu Lys Gly Ser Glu Thr Ala Phe Val Cys Asp Leu Glu Asp 
        115                 120                 125             


Glu Ser Val Asn Ile Val Glu Phe Leu Lys Arg Trp Thr Ala Phe Cys 
    130                 135                 140                 


Gln Lys Ile Met Ser Arg Leu Thr 
145                 150         


<210>  26
<211>  153
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Met Tyr Lys Val Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Leu Thr Ser Ser Ala Pro Thr Ser Ser Ser Thr Lys Glu Thr Gln Glu 
            20                  25                  30          


Gln Leu Asp Gln Leu Leu Leu Asp Leu Gln Val Leu Leu Lys Gly Val 
        35                  40                  45              


Asn Asp Tyr Lys Asn Ser Lys Leu Ser Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Val Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Gly Lys 
                85                  90                  95      


Asn Ser His Gly Gly Asn Thr Arg Glu Ser Ile Ser Asn Ile Asn Val 
            100                 105                 110         


Thr Val Leu Lys Leu Lys Gly Ser Glu Thr Phe Met Cys Glu Tyr Asp 
        115                 120                 125             


Glu Thr Val Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
    130                 135                 140                 


Gln Ser Ile Ile Ser Ala Ser Ser Ser 
145                 150             


<210>  27
<211>  155
<212>  PRT
<213>  Bos taurus

<400>  27

Met Tyr Lys Ile Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Gly Asn Thr Met Lys 
            20                  25                  30          


Glu Val Lys Ser Leu Leu Leu Asp Leu Gln Leu Leu Leu Glu Lys Val 
        35                  40                  45              


Lys Asn Pro Glu Asn Leu Lys Leu Ser Arg Met His Thr Phe Asp Phe 
    50                  55                  60                  


Tyr Val Pro Lys Val Asn Ala Thr Glu Leu Lys His Leu Lys Cys Leu 
65                  70                  75                  80  


Leu Glu Glu Leu Lys Leu Leu Glu Glu Val Leu Asn Leu Ala Pro Ser 
                85                  90                  95      


Lys Asn Leu Asn Pro Arg Glu Ile Lys Asp Ser Met Asp Asn Ile Lys 
            100                 105                 110         


Arg Ile Val Leu Glu Leu Gln Gly Ser Glu Thr Arg Phe Thr Cys Glu 
        115                 120                 125             


Tyr Asp Asp Ala Thr Val Asn Ala Val Glu Phe Leu Asn Lys Trp Ile 
    130                 135                 140                 


Thr Phe Cys Gln Ser Ile Tyr Ser Thr Met Thr 
145                 150                 155 


<210>  28
<211>  155
<212>  PRT
<213>  Ovis aries

<400>  28

Met Tyr Lys Ile Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Gly Asn Thr Met Lys 
            20                  25                  30          


Glu Val Lys Ser Leu Leu Leu Asp Leu Gln Leu Leu Leu Glu Lys Val 
        35                  40                  45              


Lys Asn Pro Glu Asn Leu Lys Leu Ser Arg Met His Thr Phe Asn Phe 
    50                  55                  60                  


Tyr Met Pro Lys Val Asn Ala Thr Glu Leu Lys His Leu Lys Cys Leu 
65                  70                  75                  80  


Leu Glu Glu Leu Lys Leu Leu Glu Glu Val Leu Asp Leu Ala Pro Ser 
                85                  90                  95      


Lys Asn Leu Asn Thr Arg Glu Ile Lys Asp Ser Met Asp Asn Ile Lys 
            100                 105                 110         


Arg Ile Val Leu Glu Leu Gln Gly Ser Glu Thr Arg Phe Thr Cys Glu 
        115                 120                 125             


Tyr Asp Asp Ala Thr Val Lys Ala Val Glu Phe Leu Asn Lys Trp Ile 
    130                 135                 140                 


Thr Phe Cys Gln Ser Ile Tyr Ser Thr Met Thr 
145                 150                 155 


<210>  29
<211>  162
<212>  PRT
<213>  Cervus elaphus

<400>  29

Met Tyr Lys Ile Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Gly Asn Thr Met Lys 
            20                  25                  30          


Glu Val Lys Ser Leu Leu Leu Asp Leu Gln Leu Leu Leu Glu Lys Val 
        35                  40                  45              


Lys Asn Pro Glu Asn Leu Lys Leu Ser Lys Met His Thr Phe Asn Phe 
    50                  55                  60                  


Phe Met Pro Lys Val Asn Ala Thr Glu Leu Lys His Leu Asn Cys Leu 
65                  70                  75                  80  


Leu Glu Glu Leu Lys Leu Leu Glu Asp Val Leu Ser Leu Ser Pro Ser 
                85                  90                  95      


Lys Asn Leu Asn Pro Lys Glu Ile Lys Asp Ser Met Asp Glu Ile Lys 
            100                 105                 110         


Asp Leu Met Asp Asn Ile Lys Arg Ile Val Leu Glu Leu Gln Gly Ser 
        115                 120                 125             


Glu Thr Ser Phe Lys Cys Glu Tyr Asp Ala Ala Thr Val Lys Ala Val 
    130                 135                 140                 


Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Arg Ile Tyr Ser Thr 
145                 150                 155                 160 


Met Thr 
        


<210>  30
<211>  155
<212>  PRT
<213>  Capra hircus

<400>  30

Met Tyr Lys Ile Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Gly Asn Thr Met Lys 
            20                  25                  30          


Glu Val Lys Ser Leu Leu Leu Asp Leu Gln Leu Leu Leu Glu Lys Val 
        35                  40                  45              


Lys Asn Pro Glu Asn Leu Lys Leu Ser Arg Met His Thr Phe Asn Phe 
    50                  55                  60                  


Tyr Met Pro Lys Val Asn Ala Thr Glu Leu Lys His Leu Lys Cys Leu 
65                  70                  75                  80  


Leu Glu Glu Leu Lys Leu Leu Glu Glu Val Leu Asp Leu Ala Pro Ser 
                85                  90                  95      


Lys Asn Leu Asn Thr Arg Glu Ile Lys Asp Ser Met Asp Asn Ile Lys 
            100                 105                 110         


Arg Ile Val Leu Glu Leu Gln Gly Ser Glu Thr Arg Phe Thr Cys Glu 
        115                 120                 125             


Tyr Asp Asp Ala Thr Val Lys Ala Val Glu Phe Leu Asn Lys Trp Ile 
    130                 135                 140                 


Thr Phe Cys Gln Ser Ile Tyr Ser Thr Met Thr 
145                 150                 155 


<210>  31
<211>  154
<212>  PRT
<213>  Delphinapterus leucas

<400>  31

Met Tyr Lys Met Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Glu Asn Thr Lys Lys 
            20                  25                  30          


Gln Val Gln Ser Leu Leu Gln Asp Leu His Leu Leu Leu Lys Glu Ile 
        35                  40                  45              


Asn Asn Tyr Glu Asn Leu Lys Leu Phe Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Ala 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Asp Val Leu Asn Val Ala Gln Ser Lys 
                85                  90                  95      


Thr Gln Asn Ser Ile Asp Ile Lys Asp Leu Met Asp Asn Ile Asn Arg 
            100                 105                 110         


Ile Val Leu Thr Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Glu Tyr 
        115                 120                 125             


Asp Asp Glu Thr Val Thr Ala Val Glu Phe Leu Asn Lys Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Tyr Ser Thr Met Thr 
145                 150                 


<210>  32
<211>  154
<212>  PRT
<213>  Orcinus orca

<400>  32

Met Tyr Lys Met Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Glu Asn Thr Lys Lys 
            20                  25                  30          


Gln Val Gln Ser Leu Leu Gln Asp Leu His Leu Leu Leu Lys Glu Ile 
        35                  40                  45              


Asn Asn Tyr Glu Asn Leu Lys Leu Phe Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Ala 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Asp Val Leu Asn Val Ala Gln Ser Lys 
                85                  90                  95      


Thr Gln Asn Ser Ile Asp Ile Lys Asp Leu Met Asp Asn Ile Asn Arg 
            100                 105                 110         


Ile Val Leu Thr Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Glu Tyr 
        115                 120                 125             


Asp Asp Glu Thr Val Thr Ala Val Glu Leu Leu Asn Lys Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Tyr Ser Thr Met Thr 
145                 150                 


<210>  33
<211>  155
<212>  PRT
<213>  Sus scrofa

<400>  33

Met Tyr Lys Met Gln Leu Leu Cys Cys Ile Ala Leu Thr Leu Ala Leu 
1               5                   10                  15      


Met Ala Asn Gly Ala Pro Thr Ser Ser Ser Thr Lys Asn Thr Lys Lys 
            20                  25                  30          


Gln Leu Glu Pro Leu Leu Leu Asp Leu Gln Leu Leu Leu Lys Glu Val 
        35                  40                  45              


Lys Asn Tyr Glu Asn Ala Asp Leu Ser Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Gln Ala Thr Glu Leu Lys His Leu Gln Cys Leu Val 
65                  70                  75                  80  


Glu Glu Leu Lys Ala Leu Glu Gly Val Leu Asn Leu Gly Gln Ser Lys 
                85                  90                  95      


Asn Ser Asp Ser Ala Asn Ile Lys Glu Ser Met Asn Asn Ile Asn Val 
            100                 105                 110         


Thr Val Leu Glu Leu Lys Val Arg Tyr Tyr Phe Ile Cys Ser Pro Gly 
        115                 120                 125             


Asn Lys Ile Asn Gly Arg Ala Phe Gln Gly Gly Ile Lys Phe Leu Val 
    130                 135                 140                 


Phe Val Lys Tyr Ser Cys Ile Leu Ser Ala Leu 
145                 150                 155 


<210>  34
<211>  149
<212>  PRT
<213>  Equus caballus

<400>  34

Met Tyr Lys Met Gln Leu Leu Ala Cys Ile Ala Leu Thr Leu Ala Val 
1               5                   10                  15      


Leu Ala Asn Ser Ala Pro Thr Ser Ser Ser Lys Arg Glu Thr Gln Gln 
            20                  25                  30          


Gln Leu Lys Gln Leu Gln Met Asp Leu Lys Leu Leu Leu Glu Gly Val 
        35                  40                  45              


Asn Asn Asn Lys Asn Pro Lys Leu Ser Lys Met Leu Thr Phe Lys Ile 
    50                  55                  60                  


Asn Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Met Leu Lys Asn Phe Leu Ser Lys 
                85                  90                  95      


Asp Ile Lys Glu Leu Met Ser Asn Ile Asn Val Thr Val Leu Gly Leu 
            100                 105                 110         


Lys Gly Ser Glu Thr Arg Phe Thr Cys Glu Tyr Asp Asp Glu Thr Gly 
        115                 120                 125             


Thr Ile Val Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Ser Ile 
    130                 135                 140                 


Phe Ser Thr Met Thr 
145                 


<210>  35
<211>  154
<212>  PRT
<213>  Felis catus

<400>  35

Met Tyr Lys Ile Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Ile Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr Gln Gln 
            20                  25                  30          


Gln Leu Glu Gln Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly Val 
        35                  40                  45              


Asn Asn Pro Glu Asn Pro Lys Leu Ser Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Val Pro Lys Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu Val 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Asn His Ile Lys Glu Leu Met Ser Asn Ile Asn Val 
            100                 105                 110         


Thr Val Leu Lys Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Asn Tyr 
        115                 120                 125             


Asp Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Lys Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr 
145                 150                 


<210>  36
<211>  155
<212>  PRT
<213>  Canis lupus

<400>  36

Met Tyr Lys Ile Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Val Leu 
1               5                   10                  15      


Val Ala Asn Ser Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu 
            20                  25                  30          


Gln Gln Met Glu Arg Leu Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly 
        35                  40                  45              


Val Asn Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Thr Pro Lys Lys Ala Thr Glu Phe Thr His Leu Gln Cys Leu 
65                  70                  75                  80  


Ala Glu Glu Leu Lys Asn Leu Glu Glu Val Leu Gly Leu Pro Gln Ser 
                85                  90                  95      


Lys Asn Val His Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn Met Asn 
            100                 105                 110         


Val Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu 
        115                 120                 125             


Tyr Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile 
    130                 135                 140                 


Thr Phe Cys Gln Ser Ile Tyr Ser Thr Met Thr 
145                 150                 155 


<210>  37
<211>  154
<212>  PRT
<213>  Halichoerus grypus

<400>  37

Met Tyr Lys Met Gln Leu Leu Ser Cys Ile Ala Leu Thr Leu Val Leu 
1               5                   10                  15      


Val Ala Asn Ser Ala Pro Thr Thr Ser Ser Ser Thr Lys Glu Thr Gln 
            20                  25                  30          


Gln Gln Leu Glu Gln Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly 
        35                  40                  45              


Val Asn Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys 
    50                  55                  60                  


Phe Tyr Thr Pro Lys Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu 
65                  70                  75                  80  


Pro Glu Glu Leu Lys Leu Leu Glu Glu Val Leu Tyr Leu Ala Pro Asn 
                85                  90                  95      


Lys Asn Phe His Leu Thr Asp Ile Lys Glu Leu Met Ser Asn Ile Asn 
            100                 105                 110         


Val Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Arg Phe Lys Cys Glu 
        115                 120                 125             


Tyr Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile 
    130                 135                 140                 


Thr Phe Cys Ser Ile Phe Ser Thr Leu Thr 
145                 150                 


<210>  38
<211>  154
<212>  PRT
<213>  Mirounga angustirostris

<400>  38

Met Cys Lys Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Val Leu 
1               5                   10                  15      


Val Ala Asn Ser Ala Pro Thr Thr Ser Ser Thr Lys Glu Thr Gln Gln 
            20                  25                  30          


Gln Leu Glu Gln Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly Val 
        35                  40                  45              


Asn Asn Tyr Glu Asp Pro Lys Leu Ser Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Thr Pro Lys Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu Ala 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Thr Asp Ile Lys Glu Leu Met Ser Asn Ile Asn Val 
            100                 105                 110         


Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Arg Phe Lys Cys Glu Tyr 
        115                 120                 125             


Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile Thr 
    130                 135                 140                 


Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr 
145                 150                 


<210>  39
<211>  143
<212>  PRT
<213>  Gallus gallus

<400>  39

Met Met Cys Lys Val Leu Ile Phe Gly Cys Ile Ser Val Ala Met Leu 
1               5                   10                  15      


Met Thr Thr Ala Tyr Gly Ala Ser Leu Ser Ser Ala Lys Arg Lys Pro 
            20                  25                  30          


Leu Gln Thr Leu Ile Lys Asp Leu Glu Ile Leu Glu Asn Ile Lys Asn 
        35                  40                  45              


Lys Ile His Leu Glu Leu Tyr Thr Pro Thr Glu Thr Gln Glu Cys Thr 
    50                  55                  60                  


Gln Gln Thr Leu Gln Cys Tyr Leu Gly Glu Val Val Thr Leu Lys Lys 
65                  70                  75                  80  


Glu Thr Glu Asp Asp Thr Glu Ile Lys Glu Glu Phe Val Thr Ala Ile 
                85                  90                  95      


Gln Asn Ile Glu Lys Asn Leu Lys Ser Leu Thr Gly Leu Asn His Thr 
            100                 105                 110         


Gly Ser Glu Cys Lys Ile Cys Glu Ala Asn Asn Lys Lys Lys Phe Pro 
        115                 120                 125             


Asp Phe Leu His Glu Leu Thr Asn Phe Val Arg Tyr Leu Gln Lys 
    130                 135                 140             


