                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Method for the generation of an FcRn expressing cell by targeted 
       integration of multiple expression cassettes in a defined 
       organization

<130>  P35375-WO

<150>  EP19166030.7
<151>  2019-03-29

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Escherichia coli

<400>  1

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  2
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIS-AVITAG

<400>  2

His His His His His His His His His His Ile Gly Leu Asn Asp Ile 
1               5                   10                  15      


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
            20                  25      


<210>  3
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
1               5                   10                  15      


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala Glu Pro Cys 
        35                  40                  45              


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
65                  70                  75                  80  


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
                85                  90                  95      


Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
            100                 105                 110         


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
        115                 120                 125             


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
    130                 135                 140                 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
145                 150                 155                 160 


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
                165                 170                 175     


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly 
            180                 185                 190         


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
        195                 200                 205             


Gln Leu Arg Phe Leu Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly 
    210                 215                 220                 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
                245                 250                 255     


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys 
            260                 265                 270         


Ser Ser 
        


<210>  4
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu a-FcRn w/ tag w/ leader

<400>  4

Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
1               5                   10                  15      


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala Glu Pro Cys 
        35                  40                  45              


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
65                  70                  75                  80  


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
                85                  90                  95      


Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
            100                 105                 110         


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
        115                 120                 125             


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
    130                 135                 140                 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
145                 150                 155                 160 


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
                165                 170                 175     


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly 
            180                 185                 190         


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
        195                 200                 205             


Gln Leu Arg Phe Leu Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly 
    210                 215                 220                 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
                245                 250                 255     


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys 
            260                 265                 270         


Ser Ser Leu Glu His His His His His His His His His His Ile Gly 
        275                 280                 285             


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    290                 295                 300         


<210>  5
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
            20                  25                  30          


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
        35                  40                  45              


Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala Glu Pro Cys 
    50                  55                  60                  


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
65                  70                  75                  80  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
                85                  90                  95      


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
            100                 105                 110         


Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
        115                 120                 125             


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
    130                 135                 140                 


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
145                 150                 155                 160 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
                165                 170                 175     


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
            180                 185                 190         


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly 
        195                 200                 205             


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
    210                 215                 220                 


Gln Leu Arg Phe Leu Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly 
225                 230                 235                 240 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
                245                 250                 255     


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
            260                 265                 270         


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys 
        275                 280                 285             


Ser Ser 
    290 


<210>  6
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu a-FcRn w/ tag w/ leader

<400>  6

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
            20                  25                  30          


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
        35                  40                  45              


Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala Glu Pro Cys 
    50                  55                  60                  


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
65                  70                  75                  80  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
                85                  90                  95      


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
            100                 105                 110         


Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
        115                 120                 125             


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
    130                 135                 140                 


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
145                 150                 155                 160 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
                165                 170                 175     


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
            180                 185                 190         


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly 
        195                 200                 205             


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
    210                 215                 220                 


Gln Leu Arg Phe Leu Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly 
225                 230                 235                 240 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
                245                 250                 255     


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
            260                 265                 270         


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys 
        275                 280                 285             


Ser Ser Leu Glu His His His His His His His His His His Ile Gly 
    290                 295                 300                 


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
305                 310                 315             


<210>  7
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  8
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  9
<211>  274
<212>  PRT
<213>  Macaca fascicularis

<400>  9

Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
1               5                   10                  15      


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Ser Tyr Asp Ser Leu Arg Gly Gln Ala Glu Pro Cys 
        35                  40                  45              


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
65                  70                  75                  80  


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
                85                  90                  95      


Glu Leu Ser Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
            100                 105                 110         


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
        115                 120                 125             


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
    130                 135                 140                 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
145                 150                 155                 160 


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
                165                 170                 175     


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn Pro Gly 
            180                 185                 190         


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
        195                 200                 205             


Gln Leu Arg Phe Leu Arg Asn Gly Met Ala Ala Gly Thr Gly Gln Gly 
    210                 215                 220                 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
                245                 250                 255     


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Thr Pro Ala Lys 
            260                 265                 270         


Ser Ser 
        


<210>  10
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cy a-FcRn w/ tag w/ leader

<400>  10

Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
1               5                   10                  15      


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Ser Tyr Asp Ser Leu Arg Gly Gln Ala Glu Pro Cys 
        35                  40                  45              


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
65                  70                  75                  80  


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
                85                  90                  95      


Glu Leu Ser Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
            100                 105                 110         


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
        115                 120                 125             


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
    130                 135                 140                 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
145                 150                 155                 160 


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
                165                 170                 175     


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn Pro Gly 
            180                 185                 190         


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
        195                 200                 205             


Gln Leu Arg Phe Leu Arg Asn Gly Met Ala Ala Gly Thr Gly Gln Gly 
    210                 215                 220                 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
                245                 250                 255     


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Thr Pro Ala Lys 
            260                 265                 270         


Ser Ser Leu Glu His His His His His His His His His His Ile Gly 
        275                 280                 285             


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    290                 295                 300         


<210>  11
<211>  290
<212>  PRT
<213>  Macaca fascicularis

<400>  11

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
            20                  25                  30          


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
        35                  40                  45              


Gln Gln Tyr Leu Ser Tyr Asp Ser Leu Arg Gly Gln Ala Glu Pro Cys 
    50                  55                  60                  


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
65                  70                  75                  80  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
                85                  90                  95      


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
            100                 105                 110         


Glu Leu Ser Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
        115                 120                 125             


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
    130                 135                 140                 


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
145                 150                 155                 160 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
                165                 170                 175     


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
            180                 185                 190         


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn Pro Gly 
        195                 200                 205             


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
    210                 215                 220                 


Gln Leu Arg Phe Leu Arg Asn Gly Met Ala Ala Gly Thr Gly Gln Gly 
225                 230                 235                 240 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
                245                 250                 255     


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
            260                 265                 270         


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Thr Pro Ala Lys 
        275                 280                 285             


Ser Ser 
    290 


<210>  12
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cy a-FcRn w/ tag w/ leader

<400>  12

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
            20                  25                  30          


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
        35                  40                  45              


Gln Gln Tyr Leu Ser Tyr Asp Ser Leu Arg Gly Gln Ala Glu Pro Cys 
    50                  55                  60                  


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
65                  70                  75                  80  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
                85                  90                  95      


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
            100                 105                 110         


Glu Leu Ser Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
        115                 120                 125             


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
    130                 135                 140                 


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
145                 150                 155                 160 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
                165                 170                 175     


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
            180                 185                 190         


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn Pro Gly 
        195                 200                 205             


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
    210                 215                 220                 


Gln Leu Arg Phe Leu Arg Asn Gly Met Ala Ala Gly Thr Gly Gln Gly 
225                 230                 235                 240 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
                245                 250                 255     


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
            260                 265                 270         


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Thr Pro Ala Lys 
        275                 280                 285             


Ser Ser Leu Glu His His His His His His His His His His Ile Gly 
    290                 295                 300                 


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
305                 310                 315             


<210>  13
<211>  95
<212>  PRT
<213>  Macaca fascicularis

<400>  13

Pro Lys Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro 
1               5                   10                  15      


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
            20                  25                  30          


Val Asp Leu Leu Lys Asn Gly Glu Lys Met Gly Lys Val Glu His Ser 
        35                  40                  45              


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
    50                  55                  60                  


Glu Phe Thr Pro Asn Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
65                  70                  75                  80  


Val Thr Leu Ser Gly Pro Arg Thr Val Lys Trp Asp Arg Asp Met 
                85                  90                  95  


<210>  14
<211>  119
<212>  PRT
<213>  Macaca fascicularis

<400>  14

Met Ser Pro Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Met Gly Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Asn Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gly Pro Arg Thr 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  15
<211>  276
<212>  PRT
<213>  Mus musculus

<400>  15

Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu Thr Ala Val Ser Asn 
1               5                   10                  15      


Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln Glu Ala Asp Pro Cys 
        35                  40                  45              


Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe Leu Glu Ala Leu Lys 
65                  70                  75                  80  


Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr Leu Gln Gly Leu Leu 
                85                  90                  95      


Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val Pro Thr Ala Val Phe 
            100                 105                 110         


Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn Pro Arg Ile Gly Asn 
        115                 120                 125             


Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val Ala Asn Leu Trp Met 
    130                 135                 140                 


Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu Phe Leu Leu Asn Ser 
145                 150                 155                 160 


Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg Gly Arg Arg Asn Leu 
                165                 170                 175     


Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn 
            180                 185                 190         


Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe Ser Phe Tyr Pro Pro 
        195                 200                 205             


Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu Ala Ser Gly Ser Gly 
    210                 215                 220                 


Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser Phe His Ala Trp Ser 
225                 230                 235                 240 


Leu Leu Glu Val Lys Arg Gly Asp Glu His His Tyr Gln Cys Gln Val 
                245                 250                 255     


Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val Asp Leu Asp Ser Ser 
            260                 265                 270         


Ala Arg Ser Ser 
        275     


<210>  16
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu a-FcRn w/ tag w/ leader

<400>  16

Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu Thr Ala Val Ser Asn 
1               5                   10                  15      


Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln Glu Ala Asp Pro Cys 
        35                  40                  45              


Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe Leu Glu Ala Leu Lys 
65                  70                  75                  80  


Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr Leu Gln Gly Leu Leu 
                85                  90                  95      


Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val Pro Thr Ala Val Phe 
            100                 105                 110         


Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn Pro Arg Ile Gly Asn 
        115                 120                 125             


Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val Ala Asn Leu Trp Met 
    130                 135                 140                 


Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu Phe Leu Leu Asn Ser 
145                 150                 155                 160 


Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg Gly Arg Arg Asn Leu 
                165                 170                 175     


Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn 
            180                 185                 190         


Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe Ser Phe Tyr Pro Pro 
        195                 200                 205             


Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu Ala Ser Gly Ser Gly 
    210                 215                 220                 


Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser Phe His Ala Trp Ser 
225                 230                 235                 240 


Leu Leu Glu Val Lys Arg Gly Asp Glu His His Tyr Gln Cys Gln Val 
                245                 250                 255     


Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val Asp Leu Asp Ser Ser 
            260                 265                 270         


Ala Arg Ser Ser Leu Glu His His His His His His His His His His 
        275                 280                 285             


Ile Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    290                 295                 300                 


<210>  17
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  17

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu Thr Ala Val Ser Asn 
            20                  25                  30          


Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr Gly Trp Leu Gly Pro 
        35                  40                  45              


Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln Glu Ala Asp Pro Cys 
    50                  55                  60                  


Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
65                  70                  75                  80  


Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe Leu Glu Ala Leu Lys 
                85                  90                  95      


Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr Leu Gln Gly Leu Leu 
            100                 105                 110         


Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val Pro Thr Ala Val Phe 
        115                 120                 125             


Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn Pro Arg Ile Gly Asn 
    130                 135                 140                 


Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val Ala Asn Leu Trp Met 
145                 150                 155                 160 


Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu Phe Leu Leu Asn Ser 
                165                 170                 175     


Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg Gly Arg Arg Asn Leu 
            180                 185                 190         


Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn 
        195                 200                 205             


Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe Ser Phe Tyr Pro Pro 
    210                 215                 220                 


Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu Ala Ser Gly Ser Gly 
225                 230                 235                 240 


Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser Phe His Ala Trp Ser 
                245                 250                 255     


Leu Leu Glu Val Lys Arg Gly Asp Glu His His Tyr Gln Cys Gln Val 
            260                 265                 270         


Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val Asp Leu Asp Ser Ser 
        275                 280                 285             


Ala Arg Ser Ser 
    290         


<210>  18
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu a-FcRn w/ tag w/ leader

<400>  18

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu Thr Ala Val Ser Asn 
            20                  25                  30          


Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr Gly Trp Leu Gly Pro 
        35                  40                  45              


Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln Glu Ala Asp Pro Cys 
    50                  55                  60                  


Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
65                  70                  75                  80  


Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe Leu Glu Ala Leu Lys 
                85                  90                  95      


Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr Leu Gln Gly Leu Leu 
            100                 105                 110         


Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val Pro Thr Ala Val Phe 
        115                 120                 125             


Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn Pro Arg Ile Gly Asn 
    130                 135                 140                 


Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val Ala Asn Leu Trp Met 
145                 150                 155                 160 


Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu Phe Leu Leu Asn Ser 
                165                 170                 175     


Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg Gly Arg Arg Asn Leu 
            180                 185                 190         


Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn 
        195                 200                 205             


Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe Ser Phe Tyr Pro Pro 
    210                 215                 220                 


Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu Ala Ser Gly Ser Gly 
225                 230                 235                 240 


Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser Phe His Ala Trp Ser 
                245                 250                 255     


Leu Leu Glu Val Lys Arg Gly Asp Glu His His Tyr Gln Cys Gln Val 
            260                 265                 270         


Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val Asp Leu Asp Ser Ser 
        275                 280                 285             


Ala Arg Ser Ser Leu Glu His His His His His His His His His His 
    290                 295                 300                 


Ile Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
305                 310                 315                 320 


<210>  19
<211>  95
<212>  PRT
<213>  Mus musculus

<400>  19

Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro 
1               5                   10                  15      


Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu 
            20                  25                  30          


Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser 
        35                  40                  45              


Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr 
    50                  55                  60                  


Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His 
65                  70                  75                  80  


Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met 
                85                  90                  95  


<210>  20
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr 
        35                  40                  45              


Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Thr Tyr Ala Cys Arg Val Lys His Asp Ser Met Ala Glu Pro Lys Thr 
            100                 105                 110         


Val Tyr Trp Asp Arg Asp Met 
        115                 


<210>  21
<211>  330
<212>  PRT
<213>  Escherichia coli

<400>  21

Ala Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Arg Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Ile Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Val 
145                 150                 155                 160 


Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Met Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile 
    210                 215                 220                 


Thr Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala 
225                 230                 235                 240 


Met Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu 
                245                 250                 255     


Gly Leu Ala Pro Tyr Leu Ser Arg Trp Glu Lys Leu Asp Asn Phe Ile 
            260                 265                 270         


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile 
        275                 280                 285             


Ser Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Ile Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu 
305                 310                 315                 320 


Lys Gly Gly Ser Asp Tyr Lys Asp Glu Leu 
                325                 330 


<210>  22
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3

<400>  22
ataacttcgt ataaagtctc ctatacgaag ttat                                   34


<210>  23
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2L

<400>  23
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  24
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  loxFas

<400>  24
acaacttcgt atataccttt ctatacgaag ttgt                                   34


<210>  25
<211>  608
<212>  DNA
<213>  Human cytomegalovirus

<400>  25
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattagc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctccg tttagtgaac      600

gtcagatc                                                               608


<210>  26
<211>  696
<212>  DNA
<213>  Human cytomegalovirus

<400>  26
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattagc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctccg tttagtgaac      600

gtcagatcta gctctgggag aggagcccag cactagaagt cggcggtgtt tccattcggt      660

gatcagcact gaacacagag gaagcttgcc gccacc                                696


<210>  27
<211>  2125
<212>  DNA
<213>  Human cytomegalovirus

<400>  27
ctgcagtgaa taataaaatg tgtgtttgtc cgaaatacgc gttttgagat ttctgtcgcc       60

gactaaattc atgtcgcgcg atagtggtgt ttatcgccga tagagatggc gatattggaa      120

aaatcgatat ttgaaaatat ggcatattga aaatgtcgcc gatgtgagtt tctgtgtaac      180

tgatatcgcc atttttccaa aagtgatttt tgggcatacg cgatatctgg cgatagcgct      240

tatatcgttt acgggggatg gcgatagacg actttggtga cttgggcgat tctgtgtgtc      300

gcaaatatcg cagtttcgat ataggtgaca gacgatatga ggctatatcg ccgatagagg      360

cgacatcaag ctggcacatg gccaatgcat atcgatctat acattgaatc aatattggcc      420

attagccata ttattcattg gttatatagc ataaatcaat attggctatt ggccattgca      480

tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc      540

atgttgacat tgattattga ctagttatta atagtaatca attacggggt cattagttca      600

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc      660

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      720

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      780

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      840

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      900

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg      960

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     1020

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     1080

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa     1140

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     1200

ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc gtgccaagag     1260

tgacgtaagt accgcctata gagtctatag gcccaccccc ttggcttctt atgcatgcta     1320

tactgttttt ggcttggggt ctatacaccc ccgcttcctc atgttatagg tgatggtata     1380

gcttagccta taggtgtggg ttattgacca ttattgacca ctcccctatt ggtgacgata     1440

ctttccatta ctaatccata acatggctct ttgccacaac tctctttatt ggctatatgc     1500

caatacactg tccttcagag actgacacgg actctgtatt tttacaggat ggggtctcat     1560

ttattattta caaattcaca tatacaacac caccgtcccc agtgcccgca gtttttatta     1620

aacataacgt gggatctcca cgcgaatctc gggtacgtgt tccggacatg ggctcttctc     1680

cggtagcggc ggagcttcta catccgagcc ctgctcccat gcctccagcg actcatggtc     1740

gctcggcagc tccttgctcc taacagtgga ggccagactt aggcacagca cgatgcccac     1800

caccaccagt gtgccgcaca aggccgtggc ggtagggtat gtgtctgaaa atgagctcgg     1860

ggagcgggct tgcaccgctg acgcatttgg aagacttaag gcagcggcag aagaagatgc     1920

aggcagctga gttgttgtgt tctgataaga gtcagaggta actcccgttg cggtgctgtt     1980

aacggtggag ggcagtgtag tctgagcagt actcgttgct gccgcgcgcg ccaccagaca     2040

taatagctga cagactaaca gactgttcct ttccatgggt cttttctgca gtcaccgtcc     2100

ttgacacggt ttaaacgccg ccacc                                           2125


<210>  28
<211>  129
<212>  DNA
<213>  Simian virus 40

<400>  28
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcacc attctagttg tggtttgtcc aaactcatca atgtatctta      120

tcatgtctg                                                              129


<210>  29
<211>  225
<212>  DNA
<213>  Bos taurus

<400>  29
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  30
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  30
caggataata tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta       60

ttttattttt gag                                                          73


<210>  31
<211>  288
<212>  DNA
<213>  Simian virus 40

<400>  31
agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca       60

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa      120

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag      180

aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag      240

gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcg                   288


<210>  32
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  green fluorescent protein encoding nucleic acid

<400>  32
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtcc      720

ggactcagat ctcgagctca agcttcgaat tctgcagtcg acggtaccgc gggcccggga      780

tccaccggat ctagatga                                                    798


