                         б

<110>  ϺҽҩŹɷ޹˾
 
<120>  һְԭʶϸӦ

<130>  0124-PA-002

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  242
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  GC33

<400>  1

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  2
<211>  258
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P4G2

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu 
        


<210>  3
<211>  1518
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  GC33CAR

<400>  3
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagcccttta tctttacccg ttacacccgg tgagcccgct      120

agcatctctt gtagaagcag ccagtcttta gtgcacagca acggcaacac atatttacac      180

tggtatttac agaagcccgg tcagagcccc cagctgctga tctacaaggt gagcaatcgt      240

ttctccggcg tgcccgatag attcagcggc agcggctccg gaaccgactt cactttaaag      300

atcagcagag tggaggccga ggacgtgggt gtgtactact gctcccagaa cacccacgtg      360

ccccctacat tcggtcaagg taccaaactg gagatcaaag gtggcggtgg ctcgggcggt      420

ggtgggtcgg gtggcggcgg atctcaagtt cagctggtgc agagcggcgc cgaggtcaaa      480

aaacccggag ccagcgtgaa ggtgtcttgt aaagccagcg gctacacctt taccgactat      540

gagatgcact gggtgagaca agctcccggt caaggtctgg aatggatggg cgctttagac      600

cccaagactg gtgacacagc ctactcccag aagttcaagg gtcgtgtgac tttaacagcc      660

gacgagtcca ccagcacagc ctacatggaa ctgagctctt taaggagcga ggacaccgcc      720

gtgtattact gcactcgttt ctacagctac acctactggg gccaaggtac tttagtgaca      780

gtgagcagct tcgtgccggt cttcctgcca gcgaagccca ccacgacgcc agcgccgcga      840

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      960

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     1020

tactgcaacc acaggaaccg tttctctgtt gttaaacggg gcagaaagaa gctcctgtat     1080

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1140

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1200

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1260

cgaagagagg agtacgatgt tttggacaaa agaagaggcc gggaccctga gatgggggga     1320

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1380

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1440

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1500

gccctgcccc ctcgctaa                                                   1518


<210>  4
<211>  882
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  P4G2CAR

<400>  4
atggctctgc ccgtgaccgc tctgctgctg cctctcgctc tgctgctgca tgccgccaga       60

cccggctccc aagtgcaact ccagcaatcc ggacccggac tggtgacacc ctcccaaaca      120

ctgtccctca catgcgccat cagcggagat tccgtgtcct ccaacagcgc tacatggaat      180

tggattagac agagcccttc cagaggactg gagtggctcg gaagaacata ctacagatcc      240

aagtggtata acgactacgc cgtgtccgtg aagtctagaa tgagcatcaa ccccgacacc      300

agcaagaacc agttttctct gcagctgaac agcgtgacac ccgaggacac cgctgtgtac      360

tactgcgcca gaggcatgat gacctactac tacggcatgg acgtctgggg acaaggcacc      420

accgtgacag tgagcagcgg cattctgggc tccggaggag gcggaagcgg aggcggaggc      480

agcggaggcg gcggaagcca acccgtgctc acacaaagct cctctctgag cgctagcccc      540

ggcgcctccg cttctctgac atgtacactg aggagcggca tcaacgtcgg accctataga      600

atctactggt accagcagaa gcccggcagc cccccccaat atctgctgaa ctacaagtcc      660

gactccgaca agcagcaagg cagcggcgtg ccttctagat tcagcggcag caaggacgct      720

agcgccaacg ccggagtgct gctgatctcc ggactgagaa gcgaggacga ggccgactac      780

tattgcatga tctggcactc cagcgccgct gtctttggag gaggcacaca gctgacagtg      840

ctgagcgcca gcttcgtgcc cgtgttcctc cccgccaaac cc                         882


<210>  5
<211>  505
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  GC33CAR


<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr 
        195                 200                 205             


Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala Lys 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Phe Ser Val Val Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505 


<210>  6
<211>  294
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P4G2CAR

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
        35                  40                  45              


Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser 
65                  70                  75                  80  


Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile 
                85                  90                  95      


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
            100                 105                 110         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser 
            180                 185                 190         


Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys 
    210                 215                 220                 


Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala 
225                 230                 235                 240 


Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp 
                245                 250                 255     


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe 
            260                 265                 270         


Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala Ser Phe Val Pro Val 
        275                 280                 285             


Phe Leu Pro Ala Lys Pro 
    290                 


<210>  7
<211>  3282
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  GC33CAR-IRES-S1PR1

<400>  7
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagcccttta tctttacccg ttacacccgg tgagcccgct      120

agcatctctt gtagaagcag ccagtcttta gtgcacagca acggcaacac atatttacac      180

tggtatttac agaagcccgg tcagagcccc cagctgctga tctacaaggt gagcaatcgt      240

ttctccggcg tgcccgatag attcagcggc agcggctccg gaaccgactt cactttaaag      300

atcagcagag tggaggccga ggacgtgggt gtgtactact gctcccagaa cacccacgtg      360

ccccctacat tcggtcaagg taccaaactg gagatcaaag gtggcggtgg ctcgggcggt      420

ggtgggtcgg gtggcggcgg atctcaagtt cagctggtgc agagcggcgc cgaggtcaaa      480

aaacccggag ccagcgtgaa ggtgtcttgt aaagccagcg gctacacctt taccgactat      540

gagatgcact gggtgagaca agctcccggt caaggtctgg aatggatggg cgctttagac      600

cccaagactg gtgacacagc ctactcccag aagttcaagg gtcgtgtgac tttaacagcc      660

gacgagtcca ccagcacagc ctacatggaa ctgagctctt taaggagcga ggacaccgcc      720

gtgtattact gcactcgttt ctacagctac acctactggg gccaaggtac tttagtgaca      780

gtgagcagct tcgtgccggt cttcctgcca gcgaagccca ccacgacgcc agcgccgcga      840

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      960

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     1020

tactgcaacc acaggaaccg tttctctgtt gttaaacggg gcagaaagaa gctcctgtat     1080

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1140

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1200

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1260

cgaagagagg agtacgatgt tttggacaaa agaagaggcc gggaccctga gatgggggga     1320

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1380

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1440

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1500

gccctgcccc ctcgctaagg atcccgcccc tctccctccc ccccccctaa cgttactggc     1560

cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg     1620

ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct     1680

aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca     1740

gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg     1800

aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct     1860

gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa     1920

tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt     1980

atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa     2040

aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa     2100

gcttgccaca acccacaatc tagaatgggg cccaccagcg tcccgctggt caaggcccac     2160

cgcagctcgg tctctgacta cgtcaactat gatatcatcg tccggcatta caactacacg     2220

ggaaagctga atatcagcgc ggacaaggag aacagcatta aactgacctc ggtggtgttc     2280

attctcatct gctgctttat catcctggag aacatctttg tcttgctgac catttggaaa     2340

accaagaaat tccaccgacc catgtactat tttattggca atctggccct ctcagacctg     2400

ttggcaggag tagcctacac agctaacctg ctcttgtctg gggccaccac ctacaagctc     2460

actcccgccc agtggtttct gcgggaaggg agtatgtttg tggccctgtc agcctccgtg     2520

ttcagtctcc tcgccatcgc cattgagcgc tatatcacaa tgctgaaaat gaaactccac     2580

aacgggagca ataacttccg cctcttcctg ctaatcagcg cctgctgggt catctccctc     2640

atcctgggtg gcctgcctat catgggctgg aactgcatca gtgcgctgtc cagctgctcc     2700

accgtgctgc cgctctacca caagcactat atcctcttct gcaccacggt cttcactctg     2760

cttctgctct ccatcgtcat tctgtactgc agaatctact ccttggtcag gactcggagc     2820

cgccgcctga cgttccgcaa gaacatttcc aaggccagcc gcagctctga gaagtcgctg     2880

gcgctgctca agaccgtaat tatcgtcctg agcgtcttca tcgcctgctg ggcaccgctc     2940

ttcatcctgc tcctgctgga tgtgggctgc aaggtgaaga cctgtgacat cctcttcaga     3000

gcggagtact tcctggtgtt agctgtgctc aactccggca ccaaccccat catttacact     3060

ctgaccaaca aggagatgcg tcgggccttc atccggatca tgtcctgctg caagtgcccg     3120

agcggagact ctgctggcaa attcaagcga cccatcatcg ccggcatgga attcagccgc     3180

agcaaatcgg acaattcctc ccacccccag aaagacgaag gggacaaccc agagaccatt     3240

atgtcttctg gaaacgtcaa ctcttcttcc ggaagcggat aa                        3282


<210>  8
<211>  2727
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S1PR1-2A-GC33CAR

<400>  8
atggggccca ccagcgtccc gctggtcaag gcccaccgca gctcggtctc tgactacgtc       60

aactatgata tcatcgtccg gcattacaac tacacgggaa agctgaatat cagcgcggac      120

aaggagaaca gcattaaact gacctcggtg gtgttcattc tcatctgctg ctttatcatc      180

ctggagaaca tctttgtctt gctgaccatt tggaaaacca agaaattcca ccgacccatg      240

tactatttta ttggcaatct ggccctctca gacctgttgg caggagtagc ctacacagct      300

aacctgctct tgtctggggc caccacctac aagctcactc ccgcccagtg gtttctgcgg      360

gaagggagta tgtttgtggc cctgtcagcc tccgtgttca gtctcctcgc catcgccatt      420

gagcgctata tcacaatgct gaaaatgaaa ctccacaacg ggagcaataa cttccgcctc      480

ttcctgctaa tcagcgcctg ctgggtcatc tccctcatcc tgggtggcct gcctatcatg      540

ggctggaact gcatcagtgc gctgtccagc tgctccaccg tgctgccgct ctaccacaag      600

cactatatcc tcttctgcac cacggtcttc actctgcttc tgctctccat cgtcattctg      660

tactgcagaa tctactcctt ggtcaggact cggagccgcc gcctgacgtt ccgcaagaac      720

atttccaagg ccagccgcag ctctgagaag tcgctggcgc tgctcaagac cgtaattatc      780

gtcctgagcg tcttcatcgc ctgctgggca ccgctcttca tcctgctcct gctggatgtg      840

ggctgcaagg tgaagacctg tgacatcctc ttcagagcgg agtacttcct ggtgttagct      900

gtgctcaact ccggcaccaa ccccatcatt tacactctga ccaacaagga gatgcgtcgg      960

gccttcatcc ggatcatgtc ctgctgcaag tgcccgagcg gagactctgc tggcaaattc     1020

aagcgaccca tcatcgccgg catggaattc agccgcagca aatcggacaa ttcctcccac     1080

ccccagaaag acgaagggga caacccagag accattatgt cttctggaaa cgtcaactct     1140

tcttccggaa gcggaggaag cggagagggc agaggaagtc tgctaacatg cggtgacgtc     1200

gaggagaatc ctggacctat ggccttacca gtgaccgcct tgctcctgcc gctggccttg     1260

ctgctccacg ccgccaggcc ggacgtggtg atgacccaga gccctttatc tttacccgtt     1320

acacccggtg agcccgctag catctcttgt agaagcagcc agtctttagt gcacagcaac     1380

ggcaacacat atttacactg gtatttacag aagcccggtc agagccccca gctgctgatc     1440

tacaaggtga gcaatcgttt ctccggcgtg cccgatagat tcagcggcag cggctccgga     1500

accgacttca ctttaaagat cagcagagtg gaggccgagg acgtgggtgt gtactactgc     1560

tcccagaaca cccacgtgcc ccctacattc ggtcaaggta ccaaactgga gatcaaaggt     1620

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctcaagttca gctggtgcag     1680

agcggcgccg aggtcaaaaa acccggagcc agcgtgaagg tgtcttgtaa agccagcggc     1740

tacaccttta ccgactatga gatgcactgg gtgagacaag ctcccggtca aggtctggaa     1800

tggatgggcg ctttagaccc caagactggt gacacagcct actcccagaa gttcaagggt     1860

cgtgtgactt taacagccga cgagtccacc agcacagcct acatggaact gagctcttta     1920

aggagcgagg acaccgccgt gtattactgc actcgtttct acagctacac ctactggggc     1980

caaggtactt tagtgacagt gagcagcttc gtgccggtct tcctgccagc gaagcccacc     2040

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc     2100

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac     2160

ttcgcctgtg atttctggtt acccatagga tgtgcagcct ttgttgtagt ctgcattttg     2220

ggatgcatac ttatttgttg gcttacacgt ttctctgttg ttaaacgggg cagaaagaag     2280

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     2340

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     2400

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     2460

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     2520

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     2580

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     2640

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     2700

cacatgcagg ccctgccccc tcgctaa                                         2727


<210>  9
<211>  2799
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S1PR1-2A-P4G2CAR

<400>  9
atggggccca ccagcgtccc gctggtcaag gcccaccgca gctcggtctc tgactacgtc       60

aactatgata tcatcgtccg gcattacaac tacacgggaa agctgaatat cagcgcggac      120

aaggagaaca gcattaaact gacctcggtg gtgttcattc tcatctgctg ctttatcatc      180

ctggagaaca tctttgtctt gctgaccatt tggaaaacca agaaattcca ccgacccatg      240

tactatttta ttggcaatct ggccctctca gacctgttgg caggagtagc ctacacagct      300

aacctgctct tgtctggggc caccacctac aagctcactc ccgcccagtg gtttctgcgg      360

gaagggagta tgtttgtggc cctgtcagcc tccgtgttca gtctcctcgc catcgccatt      420

gagcgctata tcacaatgct gaaaatgaaa ctccacaacg ggagcaataa cttccgcctc      480

ttcctgctaa tcagcgcctg ctgggtcatc tccctcatcc tgggtggcct gcctatcatg      540

ggctggaact gcatcagtgc gctgtccagc tgctccaccg tgctgccgct ctaccacaag      600

cactatatcc tcttctgcac cacggtcttc actctgcttc tgctctccat cgtcattctg      660

tactgcagaa tctactcctt ggtcaggact cggagccgcc gcctgacgtt ccgcaagaac      720

atttccaagg ccagccgcag ctctgagaag tcgctggcgc tgctcaagac cgtaattatc      780

gtcctgagcg tcttcatcgc ctgctgggca ccgctcttca tcctgctcct gctggatgtg      840

ggctgcaagg tgaagacctg tgacatcctc ttcagagcgg agtacttcct ggtgttagct      900

gtgctcaact ccggcaccaa ccccatcatt tacactctga ccaacaagga gatgcgtcgg      960

gccttcatcc ggatcatgtc ctgctgcaag tgcccgagcg gagactctgc tggcaaattc     1020

aagcgaccca tcatcgccgg catggaattc agccgcagca aatcggacaa ttcctcccac     1080

ccccagaaag acgaagggga caacccagag accattatgt cttctggaaa cgtcaactct     1140

tcttccggaa gcggaggaag cggagagggc agaggaagtc tgctaacatg cggtgacgtc     1200

gaggagaatc ctggacctat ggctctgccc gtgaccgctc tgctgctgcc tctcgctctg     1260

ctgctgcatg ccgccagacc cggctcccaa gtgcaactcc agcaatccgg acccggactg     1320

gtgacaccct cccaaacact gtccctcaca tgcgccatca gcggagattc cgtgtcctcc     1380

aacagcgcta catggaattg gattagacag agcccttcca gaggactgga gtggctcgga     1440

agaacatact acagatccaa gtggtataac gactacgccg tgtccgtgaa gtctagaatg     1500

agcatcaacc ccgacaccag caagaaccag ttttctctgc agctgaacag cgtgacaccc     1560

gaggacaccg ctgtgtacta ctgcgccaga ggcatgatga cctactacta cggcatggac     1620

gtctggggac aaggcaccac cgtgacagtg agcagcggca ttctgggctc cggaggaggc     1680

ggaagcggag gcggaggcag cggaggcggc ggaagccaac ccgtgctcac acaaagctcc     1740

tctctgagcg ctagccccgg cgcctccgct tctctgacat gtacactgag gagcggcatc     1800

aacgtcggac cctatagaat ctactggtac cagcagaagc ccggcagccc cccccaatat     1860

ctgctgaact acaagtccga ctccgacaag cagcaaggca gcggcgtgcc ttctagattc     1920

agcggcagca aggacgctag cgccaacgcc ggagtgctgc tgatctccgg actgagaagc     1980

gaggacgagg ccgactacta ttgcatgatc tggcactcca gcgccgctgt ctttggagga     2040

ggcacacagc tgacagtgct gagcgccagc ttcgtgcccg tgttcctccc cgccaaaccc     2100

accacaacac ccgcccctag accccctaca cccgccccta ccatcgcttc ccagcctctg     2160

tctctgagac ccgaggcttg tagacccgcc gctggaggag ctgtgcatac aagaggactg     2220

gacttcgctt gcgacatcta tatttgggct cccctcgctg gaacatgcgg agtgctgctg     2280

ctgtctctgg tgatcacact gtactgcaac catagaaaca gattctccgt ggtgaagaga     2340

ggaagaaaga aactgctcta catcttcaag cagcccttca tgaggcccgt gcagaccaca     2400

caagaggagg acggatgtag ctgtagattc cccgaagagg aggagggagg atgtgagctg     2460

agagtgaagt tctctagatc cgccgatgcc cccgcctacc agcaaggcca gaaccagctc     2520

tataacgagc tcaatctggg aagaagagag gagtacgacg tgctggacaa gaggagggga     2580

agagaccccg aaatgggcgg caagcccaga aggaaaaacc cccaagaggg actgtacaac     2640

gaactgcaga aggacaagat ggctgaggcc tacagcgaaa tcggcatgaa aggcgagagg     2700

aggagaggca aaggacacga cggactctat caaggcctca gcaccgccac caaggacacc     2760

tacgatgctc tgcatatgca agctctgccc cctagataa                            2799


<210>  10
<211>  2484
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S1PR1-IRES-GFP

<400>  10
atggggccca ccagcgtccc gctggtcaag gcccaccgca gctcggtctc tgactacgtc       60

aactatgata tcatcgtccg gcattacaac tacacgggaa agctgaatat cagcgcggac      120

aaggagaaca gcattaaact gacctcggtg gtgttcattc tcatctgctg ctttatcatc      180

ctggagaaca tctttgtctt gctgaccatt tggaaaacca agaaattcca ccgacccatg      240

tactatttta ttggcaatct ggccctctca gacctgttgg caggagtagc ctacacagct      300

aacctgctct tgtctggggc caccacctac aagctcactc ccgcccagtg gtttctgcgg      360

gaagggagta tgtttgtggc cctgtcagcc tccgtgttca gtctcctcgc catcgccatt      420

gagcgctata tcacaatgct gaaaatgaaa ctccacaacg ggagcaataa cttccgcctc      480

ttcctgctaa tcagcgcctg ctgggtcatc tccctcatcc tgggtggcct gcctatcatg      540

ggctggaact gcatcagtgc gctgtccagc tgctccaccg tgctgccgct ctaccacaag      600

cactatatcc tcttctgcac cacggtcttc actctgcttc tgctctccat cgtcattctg      660

tactgcagaa tctactcctt ggtcaggact cggagccgcc gcctgacgtt ccgcaagaac      720

atttccaagg ccagccgcag ctctgagaag tcgctggcgc tgctcaagac cgtaattatc      780

gtcctgagcg tcttcatcgc ctgctgggca ccgctcttca tcctgctcct gctggatgtg      840

ggctgcaagg tgaagacctg tgacatcctc ttcagagcgg agtacttcct ggtgttagct      900

gtgctcaact ccggcaccaa ccccatcatt tacactctga ccaacaagga gatgcgtcgg      960

gccttcatcc ggatcatgtc ctgctgcaag tgcccgagcg gagactctgc tggcaaattc     1020

aagcgaccca tcatcgccgg catggaattc agccgcagca aatcggacaa ttcctcccac     1080

ccccagaaag acgaagggga caacccagag accattatgt cttctggaaa cgtcaactct     1140

tcttccggaa gcggataagg atcccgcccc tctccctccc ccccccctaa cgttactggc     1200

cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg     1260

ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct     1320

aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca     1380

gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg     1440

aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct     1500

gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa     1560

tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt     1620

atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa     1680

aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa     1740

gcttgccaca acccacaatc tagaatggtg agcaagggcg aggagctgtt caccggggtg     1800

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     1860

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     1920

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc     1980

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     2040

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     2100

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     2160

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     2220

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     2280

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     2340

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     2400

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     2460

ggcatggacg agctgtacaa gtaa                                            2484


<210>  11
<211>  2844
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  GC33CAR-IRES-GFP

<400>  11
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgtgg tgatgaccca gagcccttta tctttacccg ttacacccgg tgagcccgct      120

agcatctctt gtagaagcag ccagtcttta gtgcacagca acggcaacac atatttacac      180

tggtatttac agaagcccgg tcagagcccc cagctgctga tctacaaggt gagcaatcgt      240

ttctccggcg tgcccgatag attcagcggc agcggctccg gaaccgactt cactttaaag      300

atcagcagag tggaggccga ggacgtgggt gtgtactact gctcccagaa cacccacgtg      360

ccccctacat tcggtcaagg taccaaactg gagatcaaag gtggcggtgg ctcgggcggt      420

ggtgggtcgg gtggcggcgg atctcaagtt cagctggtgc agagcggcgc cgaggtcaaa      480

aaacccggag ccagcgtgaa ggtgtcttgt aaagccagcg gctacacctt taccgactat      540

gagatgcact gggtgagaca agctcccggt caaggtctgg aatggatggg cgctttagac      600

cccaagactg gtgacacagc ctactcccag aagttcaagg gtcgtgtgac tttaacagcc      660

gacgagtcca ccagcacagc ctacatggaa ctgagctctt taaggagcga ggacaccgcc      720

gtgtattact gcactcgttt ctacagctac acctactggg gccaaggtac tttagtgaca      780

gtgagcagct tcgtgccggt cttcctgcca gcgaagccca ccacgacgcc agcgccgcga      840

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      960

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     1020

tactgcaacc acaggaaccg tttctctgtt gttaaacggg gcagaaagaa gctcctgtat     1080

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1140

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1200

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1260

cgaagagagg agtacgatgt tttggacaaa agaagaggcc gggaccctga gatgggggga     1320

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1380

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1440

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1500

gccctgcccc ctcgctaagg atcccgcccc tctccctccc ccccccctaa cgttactggc     1560

cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg     1620

ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct     1680

aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca     1740

gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg     1800

aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct     1860

gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa     1920

tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt     1980

atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa     2040

aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa     2100

gcttgccaca acccacaatc tagaatggtg agcaagggcg aggagctgtt caccggggtg     2160

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     2220

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     2280

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc     2340

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     2400

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     2460

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     2520

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     2580

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     2640

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     2700

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     2760

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     2820

ggcatggacg agctgtacaa gtaa                                            2844


<210>  12
<211>  3282
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S1PR1-IRES-GC33CAR

<400>  12
atggggccca ccagcgtccc gctggtcaag gcccaccgca gctcggtctc tgactacgtc       60

aactatgata tcatcgtccg gcattacaac tacacgggaa agctgaatat cagcgcggac      120

aaggagaaca gcattaaact gacctcggtg gtgttcattc tcatctgctg ctttatcatc      180

ctggagaaca tctttgtctt gctgaccatt tggaaaacca agaaattcca ccgacccatg      240

tactatttta ttggcaatct ggccctctca gacctgttgg caggagtagc ctacacagct      300

aacctgctct tgtctggggc caccacctac aagctcactc ccgcccagtg gtttctgcgg      360

gaagggagta tgtttgtggc cctgtcagcc tccgtgttca gtctcctcgc catcgccatt      420

gagcgctata tcacaatgct gaaaatgaaa ctccacaacg ggagcaataa cttccgcctc      480

ttcctgctaa tcagcgcctg ctgggtcatc tccctcatcc tgggtggcct gcctatcatg      540

ggctggaact gcatcagtgc gctgtccagc tgctccaccg tgctgccgct ctaccacaag      600

cactatatcc tcttctgcac cacggtcttc actctgcttc tgctctccat cgtcattctg      660

tactgcagaa tctactcctt ggtcaggact cggagccgcc gcctgacgtt ccgcaagaac      720

atttccaagg ccagccgcag ctctgagaag tcgctggcgc tgctcaagac cgtaattatc      780

gtcctgagcg tcttcatcgc ctgctgggca ccgctcttca tcctgctcct gctggatgtg      840

ggctgcaagg tgaagacctg tgacatcctc ttcagagcgg agtacttcct ggtgttagct      900

gtgctcaact ccggcaccaa ccccatcatt tacactctga ccaacaagga gatgcgtcgg      960

gccttcatcc ggatcatgtc ctgctgcaag tgcccgagcg gagactctgc tggcaaattc     1020

aagcgaccca tcatcgccgg catggaattc agccgcagca aatcggacaa ttcctcccac     1080

ccccagaaag acgaagggga caacccagag accattatgt cttctggaaa cgtcaactct     1140

tcttccggaa gcggataagg atcccgcccc tctccctccc ccccccctaa cgttactggc     1200

cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg     1260

ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct     1320

aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca     1380

gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg     1440

aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct     1500

gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa     1560

tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt     1620

atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa     1680

aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa     1740

gcttgccaca acccacaatc tagaatggcc ttaccagtga ccgccttgct cctgccgctg     1800

gccttgctgc tccacgccgc caggccggac gtggtgatga cccagagccc tttatcttta     1860

cccgttacac ccggtgagcc cgctagcatc tcttgtagaa gcagccagtc tttagtgcac     1920

agcaacggca acacatattt acactggtat ttacagaagc ccggtcagag cccccagctg     1980

ctgatctaca aggtgagcaa tcgtttctcc ggcgtgcccg atagattcag cggcagcggc     2040

tccggaaccg acttcacttt aaagatcagc agagtggagg ccgaggacgt gggtgtgtac     2100

tactgctccc agaacaccca cgtgccccct acattcggtc aaggtaccaa actggagatc     2160

aaaggtggcg gtggctcggg cggtggtggg tcgggtggcg gcggatctca agttcagctg     2220

gtgcagagcg gcgccgaggt caaaaaaccc ggagccagcg tgaaggtgtc ttgtaaagcc     2280

agcggctaca cctttaccga ctatgagatg cactgggtga gacaagctcc cggtcaaggt     2340

ctggaatgga tgggcgcttt agaccccaag actggtgaca cagcctactc ccagaagttc     2400

aagggtcgtg tgactttaac agccgacgag tccaccagca cagcctacat ggaactgagc     2460

tctttaagga gcgaggacac cgccgtgtat tactgcactc gtttctacag ctacacctac     2520

tggggccaag gtactttagt gacagtgagc agcttcgtgc cggtcttcct gccagcgaag     2580

cccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     2640

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     2700

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     2760

ctcctgtcac tggttatcac cctttactgc aaccacagga accgtttctc tgttgttaaa     2820

cggggcagaa agaagctcct gtatatattc aaacaaccat ttatgagacc agtacaaact     2880

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     2940

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     3000

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caaaagaaga     3060

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     3120

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     3180

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     3240

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        3282


<210>  13
<211>  574
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  IRES

<400>  13
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg       60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg      120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg      180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca      240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct      300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca      360

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa      420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg      480

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg      540

ggacgtggtt ttcctttgaa aaacacgatg ataa                                  574


<210>  14
<211>  54
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  2A

<400>  14
gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg acct             54


<210>  15
<211>  720
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  GFP

<400>  15
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


