﻿                         序列表

<110>  中山大学

<120>  慢性炎症和病毒感染的诊断和治疗

<150>  201910256220.3
<151>  2019-04-01

<150>  202010122554.4
<151>  2020-02-27

<160>  25

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Phe Ala Gln Asp Phe 
    50                  55                  60                  
Gln Gly Arg Phe Thr Phe Thr Leu Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Tyr Gly Tyr Ser Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210>  2
<211>  286
<212>  PRT
<213>  智人(Homo sapiens)

<400>  2
Met Ser Ala Pro Leu Asp Ala Ala Leu His Ala Leu Gln Glu Glu Gln 
1               5                   10                  15      
Ala Arg Leu Lys Met Arg Leu Trp Asp Leu Gln Gln Leu Arg Lys Glu 
            20                  25                  30          
Leu Gly Asp Ser Pro Lys Asp Lys Val Pro Phe Ser Val Pro Lys Ile 
        35                  40                  45              
Pro Leu Val Phe Arg Gly His Thr Gln Gln Asp Pro Glu Val Pro Lys 
    50                  55                  60                  
Ser Leu Val Ser Asn Leu Arg Ile His Cys Pro Leu Leu Ala Gly Ser 
65                  70                  75                  80  
Ala Leu Ile Thr Phe Asp Asp Pro Lys Val Ala Glu Gln Val Leu Gln 
                85                  90                  95      
Gln Lys Glu His Thr Ile Asn Met Glu Glu Cys Arg Leu Arg Val Gln 
            100                 105                 110         
Val Gln Pro Leu Glu Leu Pro Met Val Thr Thr Ile Gln Val Met Ser 
        115                 120                 125             
Gln Leu Ser Gly Arg Arg Val Leu Val Thr Gly Phe Pro Ala Ser Leu 
    130                 135                 140                 
Arg Leu Ser Glu Glu Glu Leu Leu Asp Lys Leu Glu Ile Phe Phe Gly 
145                 150                 155                 160 
Lys Thr Arg Asn Gly Gly Gly Asp Val Asp Val Arg Glu Leu Leu Pro 
                165                 170                 175     
Gly Ser Val Met Leu Gly Phe Ala Arg Asp Gly Val Ala Gln Arg Leu 
            180                 185                 190         
Cys Gln Ile Gly Gln Phe Thr Val Pro Leu Gly Gly Gln Gln Val Pro 
        195                 200                 205             
Leu Arg Val Ser Pro Tyr Val Asn Gly Glu Ile Gln Lys Ala Glu Ile 
    210                 215                 220                 
Arg Ser Gln Pro Val Pro Arg Ser Val Leu Val Leu Asn Ile Pro Asp 
225                 230                 235                 240 
Ile Leu Asp Gly Pro Glu Leu His Asp Val Leu Glu Ile His Phe Gln 
                245                 250                 255     
Lys Pro Thr Arg Gly Gly Gly Glu Val Glu Ala Leu Thr Val Val Pro 
            260                 265                 270         
Gln Gly Gln Gln Gly Leu Ala Val Phe Thr Ser Glu Ser Gly 
        275                 280                 285      

<210>  3
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Met Thr Cys Gln Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Gln Pro Glu 
65                  70                  75                  80  
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  4
<211>  286
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  4
Met Ser Val Thr Leu Gln Thr Val Leu Tyr Ser Leu Gln Glu Glu Gln 
1               5                   10                  15      
Ala Arg Leu Lys Met Arg Leu Gln Glu Leu Gln Gln Leu Lys Arg Glu 
            20                  25                  30          
Arg Thr Gly Ser Pro Gly Ala Lys Ile Pro Phe Ser Val Pro Glu Val 
        35                  40                  45              
Pro Leu Val Phe Gln Gly Gln Thr Lys Gln Gly Arg Gln Val Pro Lys 
    50                  55                  60                  
Phe Val Val Ser Asn Leu Lys Val Cys Cys Pro Leu Pro Glu Gly Ser 
65                  70                  75                  80  
Ala Leu Val Thr Phe Glu Asp Pro Lys Val Val Asp Arg Leu Leu Gln 
                85                  90                  95      
Gln Lys Glu His Arg Val Asn Leu Glu Asp Cys Trp Leu Arg Val Gln 
            100                 105                 110         
Val Gln Pro Leu Glu Leu Pro Val Val Thr Asn Ile Gln Val Ser Ser 
        115                 120                 125             
Gln Pro Asp Asn His Arg Val Leu Val Ser Gly Phe Pro Ala Gly Leu 
    130                 135                 140                 
Arg Leu Ser Glu Glu Glu Leu Leu Asp Lys Leu Glu Ile Phe Phe Gly 
145                 150                 155                 160 
Lys Ala Lys Asn Gly Gly Gly Asp Val Glu Thr Arg Glu Met Leu Gln 
                165                 170                 175     
Gly Thr Val Met Leu Gly Phe Ala Asp Glu Glu Val Ala Gln His Leu 
            180                 185                 190         
Cys Gln Ile Gly Gln Phe Arg Val Pro Leu Asp Arg Gln Gln Val Leu 
        195                 200                 205             
Leu Arg Val Ser Pro Tyr Val Ser Gly Glu Ile Gln Lys Ala Glu Ile 
    210                 215                 220                 
Lys Phe Gln Gln Ala Pro His Ser Val Leu Val Thr Asn Ile Pro Asp 
225                 230                 235                 240 
Val Met Asp Ala Gln Glu Leu His Asp Ile Leu Glu Ile His Phe Gln 
                245                 250                 255     
Lys Pro Thr Arg Gly Gly Gly Glu Val Glu Ala Leu Thr Val Val Pro 
            260                 265                 270         
Ser Gly Gln Gln Gly Leu Ala Ile Phe Thr Ser Glu Ser Ser 
        275                 280                 285     

<210>  5
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Phe Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Phe Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Ile Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Tyr Gly Tyr Ser Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210>  6
<211>  314
<212>  PRT
<213>  小家鼠(Mus musculus)

<400>  6
Met Asp Ala Asp Lys Asp Asn Ile Lys Gln Ala Cys Asp Glu Arg Ser 
1               5                   10                  15      
Ala Glu Met Asp Asp Met Arg Gly Glu Gln Ser Met Gly Leu Val His 
            20                  25                  30          
Glu Ile Met Ser Glu Asn Lys Glu Leu Asp Glu Glu Ile Lys Lys Leu 
        35                  40                  45              
Glu Ala Glu Leu Gln Ser Asp Ala Arg Glu Phe Gln Ile Lys Glu Asn 
    50                  55                  60                  
Val Pro Glu Lys Lys Leu Lys Leu Thr Ser Val Glu Ser Pro Lys Asp 
65                  70                  75                  80  
Gly Cys His Phe Ser Asn Ser Ser Cys Ser Phe Gln Val Ser Ser Gln 
                85                  90                  95      
Ile Leu Tyr Glu Leu Gln Glu Gly Gln Ala Leu Ile Thr Phe Glu Lys 
            100                 105                 110         
Glu Glu Val Ala Gln Asn Val Ile Ser Met Gly Asn His Val Val Gln 
        115                 120                 125             
Met Glu Gly Thr Pro Val Lys Val Ser Ala His Pro Val Pro Leu Asn 
    130                 135                 140                 
Thr Gly Val Arg Phe Gln Val His Val Asp Ile Ser Lys Met Lys Ile 
145                 150                 155                 160 
Asn Val Thr Gly Ile Pro Asp Glu Leu Ser Glu Glu Gln Thr Arg Asp 
                165                 170                 175     
Lys Leu Glu Leu Ser Phe Cys Lys Ser Arg Asn Gly Gly Gly Glu Val 
            180                 185                 190         
Glu Ser Val Asp Tyr Asp Arg Lys Ser Arg Ser Ala Val Ile Thr Phe 
        195                 200                 205             
Val Glu Thr Gly Val Val Asp Lys Ile Leu Lys Lys Lys Thr Tyr Pro 
    210                 215                 220                 
Leu Tyr Met Asn Gln Lys Cys His Ser Val Ala Val Ser Pro Cys Ile 
225                 230                 235                 240 
Glu Arg Cys Leu Glu Lys Tyr Gln Val Phe Ser Ala Val Ser Lys Lys 
                245                 250                 255     
Thr Val Leu Leu Thr Gly Leu Glu Gly Ile Pro Val Asp Glu Glu Thr 
            260                 265                 270         
Gly Glu Asp Leu Leu Asn Ile His Phe Gln Arg Lys Asn Asn Gly Gly 
        275                 280                 285             
Gly Glu Val Glu Val Val Lys Cys Ser Leu Asp Gln Ser Phe Ala Ala 
    290                 295                 300                 
Tyr Phe Lys Glu Glu Ala Arg Glu Thr Ile 
305                 310                 

<210>  7
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Met Thr Cys Gln Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Gln Pro Glu 
65                  70                  75                  80  
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  8
<211>  307
<212>  PRT
<213>  智人(Homo sapiens)

<400>  8
Met Glu Ala Asp Lys Asp Asp Thr Gln Gln Ile Leu Lys Glu His Ser 
1               5                   10                  15      
Pro Asp Glu Phe Ile Lys Asp Glu Gln Asn Lys Gly Leu Ile Asp Glu 
            20                  25                  30          
Ile Thr Lys Lys Asn Ile Gln Leu Lys Lys Glu Ile Gln Lys Leu Glu 
        35                  40                  45              
Thr Glu Leu Gln Glu Ala Thr Lys Glu Phe Gln Ile Lys Glu Asp Ile 
    50                  55                  60                  
Pro Glu Thr Lys Met Lys Phe Leu Ser Val Glu Thr Pro Glu Asn Asp 
65                  70                  75                  80  
Ser Gln Leu Ser Asn Ile Ser Cys Ser Phe Gln Val Ser Ser Lys Val 
                85                  90                  95      
Pro Tyr Glu Ile Gln Lys Gly Gln Ala Leu Ile Thr Phe Glu Lys Glu 
            100                 105                 110         
Glu Val Ala Gln Asn Val Val Ser Met Ser Lys His His Val Gln Ile 
        115                 120                 125             
Lys Asp Val Asn Leu Glu Val Thr Ala Lys Pro Val Pro Leu Asn Ser 
    130                 135                 140                 
Gly Val Arg Phe Gln Val Tyr Val Glu Val Ser Lys Met Lys Ile Asn 
145                 150                 155                 160 
Val Thr Glu Ile Pro Asp Thr Leu Arg Glu Asp Gln Met Arg Asp Lys 
                165                 170                 175     
Leu Glu Leu Ser Phe Ser Lys Phe Arg Asn Gly Gly Gly Glu Val Asp 
            180                 185                 190         
Arg Val Asp Tyr Asp Arg Gln Ser Gly Ser Ala Val Ile Thr Phe Val 
        195                 200                 205             
Glu Ile Gly Val Ala Asp Lys Ile Leu Lys Lys Lys Glu Tyr Pro Leu 
    210                 215                 220                 
Tyr Ile Asn Gln Thr Cys His Arg Val Thr Val Ser Pro Tyr Thr Glu 
225                 230                 235                 240 
Ile His Leu Lys Lys Tyr Gln Ile Phe Ser Gly Thr Ser Lys Arg Thr 
                245                 250                 255     
Val Leu Leu Thr Gly Met Glu Gly Ile Gln Met Asp Glu Glu Ile Val 
            260                 265                 270         
Glu Asp Leu Ile Asn Ile His Phe Gln Arg Ala Lys Asn Gly Gly Gly 
        275                 280                 285             
Glu Val Asp Val Val Lys Cys Ser Leu Gly Gln Pro His Ile Ala Tyr 
    290                 295                 300                 
Phe Glu Glu 
305         

<210>  9
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Val Gln Leu Val Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
1               5                   10                  15      
Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
            20                  25                  30          
Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
        35                  40                  45              
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Phe Ala Asp Asp Phe Lys 
    50                  55                  60                  
Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
65                  70                  75                  80  
Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Tyr Gly Tyr Ser Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr 
        115                 120 

<210>  10
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  11
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Val Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Phe Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Tyr Gly Tyr Ser Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210>  12
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  13
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               

<210>  14
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               

<210>  15
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Tyr Gly Tyr Ser Trp Ala Met Asp Tyr 
1               5                   

<210>  16
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Ser Ser Ser Val Ser Tyr 
1               5       

<210>  17
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Asp Thr Ser 
1           

<210>  18
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Trp Ser Ser Asn Pro Pro Ile 
1               5           

<210>  19
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Gly Tyr Thr Phe Pro Asn Tyr Gly 
1               5               

<210>  20
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  20
Trp Ser Pro Tyr Pro Pro Ile 
1               5           

<210>  21
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Trp Ser Ser Asn Ser Trp Ser 
1               5           

<210>  22
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  22
Trp Ser Pro Leu Pro Pro Ile 
1               5           

<210>  23
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  23
Trp Ser Pro Arg Pro Pro Ile 
1               5           

<210>  24
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  24
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  25
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  25
Gln Val Gln Leu Val Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Tyr Gly Tyr Ser Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

