                               SEQUENCE LISTING

<110> SIGILON THERAPEUTICS, INC.
 
<120> COMPOSITIONS, DEVICES AND METHODS FOR TREATING FABRY DISEASE

<130> S2225-7028WO

<140>
<141>

<150> 62/907,380
<151> 2019-09-27

<150> 62/824,969
<151> 2019-03-27

<160> 51    

<170> PatentIn version 3.5

<210> 1
<211> 429
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 2
<211> 1290
<212> DNA
<213> Homo sapiens

<400> 2
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagattggt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210> 3
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgcagctga gaaaccccga actgcacctg ggatgtgccc tggctctgag atttctggcc       60

ctggtgtctt gggacatccc tggcgctaga gccctggata atggcctggc cagaacacct      120

acaatgggct ggctgcactg ggagagattc atgtgcaacc tggactgcca agaggaaccc      180

gacagctgca tcagcgagaa gctgttcatg gaaatggccg agctgatggt gtccgaaggc      240

tggaaggatg ccggctacga gtacctgtgc atcgacgact gttggatggc ccctcagaga      300

gactctgagg gcagactgca ggccgatcct cagagatttc cccacggcat tagacagctg      360

gccaactacg tgcacagcaa gggcctgaag ctgggcatct atgccgacgt gggcaacaag      420

acctgtgccg gctttcctgg cagcttcggc tactacgata tcgacgccca gaccttcgcc      480

gattggggag tcgatctgct gaagttcgac ggctgctact gcgacagcct ggaaaatctg      540

gccgacggct acaagcacat gtcactggcc ctgaatcgga ccggcagatc catcgtgtac      600

agctgcgagt ggcccctgta catgtggccc ttccagaagc ctaactacac cgagatcaga      660

cagtactgca accactggcg gaacttcgcc gacatcgacg atagctggaa gtccatcaag      720

agcatcctgg actggaccag cttcaatcaa gagcggatcg tggacgtggc aggacctggc      780

ggatggaacg atcctgacat gctggtcatc ggcaacttcg gcctgagctg gaaccagcaa      840

gtgacccaga tggccctgtg ggccattatg gccgctcctc tgttcatgag caacgacctg      900

agacacatca gccctcaggc caaggctctg ctgcaggaca aggatgtgat cgctatcaac      960

caggatcctc tgggcaagca gggctaccag ctgagacagg gcgacaattt cgaagtgtgg     1020

gaaagacccc tgagcggact ggcttgggcc gtcgccatga tcaacagaca agagatcggc     1080

ggaccccggt cctacacaat tgccgtggct tctctcggca aaggcgtggc ctgtaatccc     1140

gcctgcttta tcacacagct gctgcccgtg aagagaaagc tgggctttta cgagtggacc     1200

agcagactgc ggagccacat caatcctacc ggcacagtgc tgctgcagct ggaaaacacc     1260

atgcagatga gcctgaagga cctgctgtaa                                      1290


<210> 4
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgcagctgc gcaaccccga gctgcacctg ggctgcgccc tggccctgcg cttcctggcc       60

ctggtgagct gggacatccc cggcgcccgc gccctggaca acggcctggc ccgcaccccc      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc tggactgcca ggaggagccc      180

gacagctgca tcagcgagaa gctgttcatg gagatggccg agctgatggt gagcgagggc      240

tggaaggacg ccggctacga gtacctgtgc atcgacgact gctggatggc cccccagcgc      300

gacagcgagg gccgcctgca ggccgacccc cagcgcttcc cccacggcat ccgccagctg      360

gccaactacg tgcacagcaa gggcctgaag ctgggcatct acgccgacgt gggcaacaag      420

acctgcgccg gcttccccgg cagcttcggc tactacgaca tcgacgccca gaccttcgcc      480

gactggggcg tggacctgct gaagttcgac ggctgctact gcgacagcct ggagaacctg      540

gccgacggct acaagcacat gagcctggcc ctgaaccgca ccggccgcag catcgtgtac      600

agctgcgagt ggcccctgta catgtggccc ttccagaagc ccaactacac cgagatccgc      660

cagtactgca accactggcg caacttcgcc gacatcgacg acagctggaa gagcatcaag      720

agcatcctgg actggaccag cttcaaccag gagcgcatcg tggacgtggc cggccccggc      780

ggctggaacg accccgacat gctggtgatc ggcaacttcg gcctgagctg gaaccagcag      840

gtgacccaga tggccctgtg ggccatcatg gccgcccccc tgttcatgag caacgacctg      900

cgccacatca gcccccaggc caaggccctg ctgcaggaca aggacgtgat cgccatcaac      960

caggaccccc tgggcaagca gggctaccag ctgcgccagg gcgacaactt cgaggtgtgg     1020

gagcgccccc tgagcggcct ggcctgggcc gtggccatga tcaaccgcca ggagatcggc     1080

ggcccccgca gctacaccat cgccgtggcc agcctgggca agggcgtggc ctgcaacccc     1140

gcctgcttca tcacccagct gctgcccgtg aagcgcaagc tgggcttcta cgagtggacc     1200

agccgcctgc gcagccacat caaccccacc ggcaccgtgc tgctgcagct ggagaacacc     1260

atgcagatga gcctgaagga cctgctgtaa                                      1290


<210> 5
<211> 419
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met 
            20                  25                  30          


Gly Trp Leu His Trp Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu 
        35                  40                  45              


Glu Pro Asp Ser Cys Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu 
    50                  55                  60                  


Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys 
65                  70                  75                  80  


Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu 
                85                  90                  95      


Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn 
            100                 105                 110         


Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly 
        115                 120                 125             


Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile 
    130                 135                 140                 


Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp 
145                 150                 155                 160 


Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His 
                165                 170                 175     


Met Ser Leu Ala Leu Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys 
            180                 185                 190         


Glu Trp Pro Leu Tyr Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu 
        195                 200                 205             


Ile Arg Gln Tyr Cys Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp 
    210                 215                 220                 


Ser Trp Lys Ser Ile Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln 
225                 230                 235                 240 


Glu Arg Ile Val Asp Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp 
                245                 250                 255     


Met Leu Val Ile Gly Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr 
            260                 265                 270         


Gln Met Ala Leu Trp Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn 
        275                 280                 285             


Asp Leu Arg His Ile Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys 
    290                 295                 300                 


Asp Val Ile Ala Ile Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln 
305                 310                 315                 320 


Leu Arg Gln Gly Asp Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly 
                325                 330                 335     


Leu Ala Trp Ala Val Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro 
            340                 345                 350         


Arg Ser Tyr Thr Ile Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys 
        355                 360                 365             


Asn Pro Ala Cys Phe Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu 
    370                 375                 380                 


Gly Phe Tyr Glu Trp Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr 
385                 390                 395                 400 


Gly Thr Val Leu Leu Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys 
                405                 410                 415     


Asp Leu Leu 
            


<210> 6
<211> 1260
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctt       60

gctctggaca acggcctggc ccgcaccccc accatgggct ggctgcactg ggagcgcttc      120

atgtgcaacc tggactgcca ggaggagccc gacagctgca tcagcgagaa gctgttcatg      180

gagatggccg agctgatggt gagcgagggc tggaaggacg ccggctacga gtacctgtgc      240

atcgacgact gctggatggc cccccagcgc gacagcgagg gccgcctgca ggccgacccc      300

cagcgcttcc cccacggcat ccgccagctg gccaactacg tgcacagcaa gggcctgaag      360

ctgggcatct acgccgacgt gggcaacaag acctgcgccg gcttccccgg cagcttcggc      420

tactacgaca tcgacgccca gaccttcgcc gactggggcg tggacctgct gaagttcgac      480

ggctgctact gcgacagcct ggagaacctg gccgacggct acaagcacat gagcctggcc      540

ctgaaccgca ccggccgcag catcgtgtac agctgcgagt ggcccctgta catgtggccc      600

ttccagaagc ccaactacac cgagatccgc cagtactgca accactggcg caacttcgcc      660

gacatcgacg acagctggaa gagcatcaag agcatcctgg actggaccag cttcaaccag      720

gagcgcatcg tggacgtggc cggccccggc ggctggaacg accccgacat gctggtgatc      780

ggcaacttcg gcctgagctg gaaccagcag gtgacccaga tggccctgtg ggccatcatg      840

gccgcccccc tgttcatgag caacgacctg cgccacatca gcccccaggc caaggccctg      900

ctgcaggaca aggacgtgat cgccatcaac caggaccccc tgggcaagca gggctaccag      960

ctgcgccagg gcgacaactt cgaggtgtgg gagcgccccc tgagcggcct ggcctgggcc     1020

gtggccatga tcaaccgcca ggagatcggc ggcccccgca gctacaccat cgccgtggcc     1080

agcctgggca agggcgtggc ctgcaacccc gcctgcttca tcacccagct gctgcccgtg     1140

aagcgcaagc tgggcttcta cgagtggacc agccgcctgc gcagccacat caaccccacc     1200

ggcaccgtgc tgctgcagct ggagaacacc atgcagatga gcctgaagga cctgctgtaa     1260


<210> 7
<211> 530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met 
            20                  25                  30          


Gly Trp Leu His Trp Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu 
        35                  40                  45              


Glu Pro Asp Ser Cys Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu 
    50                  55                  60                  


Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys 
65                  70                  75                  80  


Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu 
                85                  90                  95      


Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn 
            100                 105                 110         


Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly 
        115                 120                 125             


Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile 
    130                 135                 140                 


Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp 
145                 150                 155                 160 


Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His 
                165                 170                 175     


Met Ser Leu Ala Leu Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys 
            180                 185                 190         


Glu Trp Pro Leu Tyr Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu 
        195                 200                 205             


Ile Arg Gln Tyr Cys Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp 
    210                 215                 220                 


Ser Trp Lys Ser Ile Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln 
225                 230                 235                 240 


Glu Arg Ile Val Asp Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp 
                245                 250                 255     


Met Leu Val Ile Gly Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr 
            260                 265                 270         


Gln Met Ala Leu Trp Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn 
        275                 280                 285             


Asp Leu Arg His Ile Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys 
    290                 295                 300                 


Asp Val Ile Ala Ile Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln 
305                 310                 315                 320 


Leu Arg Gln Gly Asp Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly 
                325                 330                 335     


Leu Ala Trp Ala Val Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro 
            340                 345                 350         


Arg Ser Tyr Thr Ile Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys 
        355                 360                 365             


Asn Pro Ala Cys Phe Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu 
    370                 375                 380                 


Gly Phe Tyr Glu Trp Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr 
385                 390                 395                 400 


Gly Thr Val Leu Leu Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys 
                405                 410                 415     


Asp Leu Leu Gly Gly Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe 
            420                 425                 430         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        435                 440                 445             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    450                 455                 460                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
465                 470                 475                 480 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                485                 490                 495     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            500                 505                 510         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        515                 520                 525             


Glu Cys 
    530 


<210> 8
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            20                  25                  30          


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        35                  40                  45              


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    50                  55                  60                  


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
65                  70                  75                  80  


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                85                  90                  95      


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            100                 105                 110         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     


<210> 9
<211> 1593
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctt       60

gctctggaca acggcctggc ccgcaccccc accatgggct ggctgcactg ggagcgcttc      120

atgtgcaacc tggactgcca ggaggagccc gacagctgca tcagcgagaa gctgttcatg      180

gagatggccg agctgatggt gagcgagggc tggaaggacg ccggctacga gtacctgtgc      240

atcgacgact gctggatggc cccccagcgc gacagcgagg gccgcctgca ggccgacccc      300

cagcgcttcc cccacggcat ccgccagctg gccaactacg tgcacagcaa gggcctgaag      360

ctgggcatct acgccgacgt gggcaacaag acctgcgccg gcttccccgg cagcttcggc      420

tactacgaca tcgacgccca gaccttcgcc gactggggcg tggacctgct gaagttcgac      480

ggctgctact gcgacagcct ggagaacctg gccgacggct acaagcacat gagcctggcc      540

ctgaaccgca ccggccgcag catcgtgtac agctgcgagt ggcccctgta catgtggccc      600

ttccagaagc ccaactacac cgagatccgc cagtactgca accactggcg caacttcgcc      660

gacatcgacg acagctggaa gagcatcaag agcatcctgg actggaccag cttcaaccag      720

gagcgcatcg tggacgtggc cggccccggc ggctggaacg accccgacat gctggtgatc      780

ggcaacttcg gcctgagctg gaaccagcag gtgacccaga tggccctgtg ggccatcatg      840

gccgcccccc tgttcatgag caacgacctg cgccacatca gcccccaggc caaggccctg      900

ctgcaggaca aggacgtgat cgccatcaac caggaccccc tgggcaagca gggctaccag      960

ctgcgccagg gcgacaactt cgaggtgtgg gagcgccccc tgagcggcct ggcctgggcc     1020

gtggccatga tcaaccgcca ggagatcggc ggcccccgca gctacaccat cgccgtggcc     1080

agcctgggca agggcgtggc ctgcaacccc gcctgcttca tcacccagct gctgcccgtg     1140

aagcgcaagc tgggcttcta cgagtggacc agccgcctgc gcagccacat caaccccacc     1200

ggcaccgtgc tgctgcagct ggagaacacc atgcagatga gcctgaagga cctgctgggc     1260

ggcagcagcc gcaccgtggc cgcccccagc gtgttcatct tcccccccag cgacgagcag     1320

ctgaagagcg gcaccgccag cgtggtgtgc ctgctgaaca acttctaccc ccgcgaggcc     1380

aaggtgcagt ggaaggtgga caacgccctg cagagcggca acagccagga gagcgtgacc     1440

gagcaggaca gcaaggacag cacctacagc ctgagcagca ccctgaccct gagcaaggcc     1500

gactacgaga agcacaaggt gtacgcctgc gaggtgaccc accagggcct gagcagcccc     1560

gtgaccaaga gcttcaaccg cggcgagtgc taa                                  1593


<210> 10
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctt       60

gctgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      120

ggcggcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      180

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccccgccgt gctgcagagc      240

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      300

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      360

cccaagagct gcgacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc      420

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      480

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      540

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac      600

aacagcacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc      660

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg cccccatcga gaagaccatc      720

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac      780

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac      840

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc      900

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc      960

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1020

acccagaaga gcctgagcct gagccccggc aagtaa                               1056


<210> 11
<211> 777
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met 
            20                  25                  30          


Gly Trp Leu His Trp Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu 
        35                  40                  45              


Glu Pro Asp Ser Cys Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu 
    50                  55                  60                  


Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys 
65                  70                  75                  80  


Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu 
                85                  90                  95      


Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn 
            100                 105                 110         


Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly 
        115                 120                 125             


Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile 
    130                 135                 140                 


Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp 
145                 150                 155                 160 


Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His 
                165                 170                 175     


Met Ser Leu Ala Leu Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys 
            180                 185                 190         


Glu Trp Pro Leu Tyr Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu 
        195                 200                 205             


Ile Arg Gln Tyr Cys Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp 
    210                 215                 220                 


Ser Trp Lys Ser Ile Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln 
225                 230                 235                 240 


Glu Arg Ile Val Asp Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp 
                245                 250                 255     


Met Leu Val Ile Gly Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr 
            260                 265                 270         


Gln Met Ala Leu Trp Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn 
        275                 280                 285             


Asp Leu Arg His Ile Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys 
    290                 295                 300                 


Asp Val Ile Ala Ile Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln 
305                 310                 315                 320 


Leu Arg Gln Gly Asp Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly 
                325                 330                 335     


Leu Ala Trp Ala Val Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro 
            340                 345                 350         


Arg Ser Tyr Thr Ile Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys 
        355                 360                 365             


Asn Pro Ala Cys Phe Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu 
    370                 375                 380                 


Gly Phe Tyr Glu Trp Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr 
385                 390                 395                 400 


Gly Thr Val Leu Leu Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys 
                405                 410                 415     


Asp Leu Leu Gly Gly Ser Ser Glu Val Gln Leu Gln Ala Ser Gly Gly 
            420                 425                 430         


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        435                 440                 445             


Gly Phe Lys Ile Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro 
    450                 455                 460                 


Gly Lys Glu Arg Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn 
465                 470                 475                 480 


Thr Phe Tyr Ser Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                485                 490                 495     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            500                 505                 510         


Asp Thr Ala Asp Tyr Tyr Cys Ala Ala Gly Ser Thr Ser Thr Ala Thr 
        515                 520                 525             


Pro Leu Arg Val Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser 
    530                 535                 540                 


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                565                 570                 575     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            580                 585                 590         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        595                 600                 605             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    610                 615                 620                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
625                 630                 635                 640 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                645                 650                 655     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            660                 665                 670         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        675                 680                 685             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    690                 695                 700                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                725                 730                 735     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            740                 745                 750         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        755                 760                 765             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775         


<210> 12
<211> 2334
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctt       60

gctctggaca acggcctggc ccgcaccccc accatgggct ggctgcactg ggagcgcttc      120

atgtgcaacc tggactgcca ggaggagccc gacagctgca tcagcgagaa gctgttcatg      180

gagatggccg agctgatggt gagcgagggc tggaaggacg ccggctacga gtacctgtgc      240

atcgacgact gctggatggc cccccagcgc gacagcgagg gccgcctgca ggccgacccc      300

cagcgcttcc cccacggcat ccgccagctg gccaactacg tgcacagcaa gggcctgaag      360

ctgggcatct acgccgacgt gggcaacaag acctgcgccg gcttccccgg cagcttcggc      420

tactacgaca tcgacgccca gaccttcgcc gactggggcg tggacctgct gaagttcgac      480

ggctgctact gcgacagcct ggagaacctg gccgacggct acaagcacat gagcctggcc      540

ctgaaccgca ccggccgcag catcgtgtac agctgcgagt ggcccctgta catgtggccc      600

ttccagaagc ccaactacac cgagatccgc cagtactgca accactggcg caacttcgcc      660

gacatcgacg acagctggaa gagcatcaag agcatcctgg actggaccag cttcaaccag      720

gagcgcatcg tggacgtggc cggccccggc ggctggaacg accccgacat gctggtgatc      780

ggcaacttcg gcctgagctg gaaccagcag gtgacccaga tggccctgtg ggccatcatg      840

gccgcccccc tgttcatgag caacgacctg cgccacatca gcccccaggc caaggccctg      900

ctgcaggaca aggacgtgat cgccatcaac caggaccccc tgggcaagca gggctaccag      960

ctgcgccagg gcgacaactt cgaggtgtgg gagcgccccc tgagcggcct ggcctgggcc     1020

gtggccatga tcaaccgcca ggagatcggc ggcccccgca gctacaccat cgccgtggcc     1080

agcctgggca agggcgtggc ctgcaacccc gcctgcttca tcacccagct gctgcccgtg     1140

aagcgcaagc tgggcttcta cgagtggacc agccgcctgc gcagccacat caaccccacc     1200

ggcaccgtgc tgctgcagct ggagaacacc atgcagatga gcctgaagga cctgctgggc     1260

ggcagcagcg aggtgcagct gcaggccagc ggcggcggcc tggtgcaggc cggcggcagc     1320

ctgcgcctga gctgcgccgc cagcggcttc aagatcaccc actacaccat gggctggttc     1380

cgccaggccc ccggcaagga gcgcgagttc gtgagccgca tcacctgggg cggcgacaac     1440

accttctaca gcaacagcgt gaagggccgc ttcaccatca gccgcgacaa cgccaagaac     1500

accgtgtacc tgcagatgaa cagcctgaag cccgaggaca ccgccgacta ctactgcgcc     1560

gccggcagca ccagcaccgc cacccccctg cgcgtggact actggggcaa gggcacccag     1620

gtgaccgtga gcagcgagcc caagagcagc gacaagaccc acacctgccc cccctgcccc     1680

gcccccgagc tgctgggcgg ccccagcgtg ttcctgttcc cccccaagcc caaggacacc     1740

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac     1800

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag     1860

ccccgcgagg agcagtacaa cagcacctac cgcgtggtga gcgtgctgac cgtgctgcac     1920

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgcc     1980

cccatcgaga agaccatcag caaggccaag ggccagcccc gcgagcccca ggtgtacacc     2040

ctgcccccca gccgcgacga gctgaccaag aaccaggtga gcctgacctg cctggtgaag     2100

ggcttctacc ccagcgacat cgccgtggag tgggagagca acggccagcc cgagaacaac     2160

tacaagacca ccccccccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     2220

accgtggaca agagccgctg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     2280

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggcaa gtaa           2334


<210> 13
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met 
            20                  25                  30          


Gly Trp Leu His Trp Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu 
        35                  40                  45              


Glu Pro Asp Ser Cys Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu 
    50                  55                  60                  


Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys 
65                  70                  75                  80  


Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu 
                85                  90                  95      


Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn 
            100                 105                 110         


Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly 
        115                 120                 125             


Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile 
    130                 135                 140                 


Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp 
145                 150                 155                 160 


Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His 
                165                 170                 175     


Met Ser Leu Ala Leu Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys 
            180                 185                 190         


Glu Trp Pro Leu Tyr Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu 
        195                 200                 205             


Ile Arg Gln Tyr Cys Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp 
    210                 215                 220                 


Ser Trp Lys Ser Ile Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln 
225                 230                 235                 240 


Glu Arg Ile Val Asp Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp 
                245                 250                 255     


Met Leu Val Ile Gly Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr 
            260                 265                 270         


Gln Met Ala Leu Trp Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn 
        275                 280                 285             


Asp Leu Arg His Ile Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys 
    290                 295                 300                 


Asp Val Ile Ala Ile Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln 
305                 310                 315                 320 


Leu Arg Gln Gly Asp Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly 
                325                 330                 335     


Leu Ala Trp Ala Val Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro 
            340                 345                 350         


Arg Ser Tyr Thr Ile Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys 
        355                 360                 365             


Asn Pro Ala Cys Phe Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu 
    370                 375                 380                 


Gly Phe Tyr Glu Trp Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr 
385                 390                 395                 400 


Gly Thr Val Leu Leu Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys 
                405                 410                 415     


Asp Leu Leu Gly Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            420                 425                 430         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        435                 440                 445             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    450                 455                 460                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
465                 470                 475                 480 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                485                 490                 495     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            500                 505                 510         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        515                 520                 525             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    530                 535                 540                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
545                 550                 555                 560 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                565                 570                 575     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            580                 585                 590         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        595                 600                 605             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    610                 615                 620                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
625                 630                 635                 640 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 655 


<210> 14
<211> 1968
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctt       60

gctctggaca acggcctggc ccgcaccccc accatgggct ggctgcactg ggagcgcttc      120

atgtgcaacc tggactgcca ggaggagccc gacagctgca tcagcgagaa gctgttcatg      180

gagatggccg agctgatggt gagcgagggc tggaaggacg ccggctacga gtacctgtgc      240

atcgacgact gctggatggc cccccagcgc gacagcgagg gccgcctgca ggccgacccc      300

cagcgcttcc cccacggcat ccgccagctg gccaactacg tgcacagcaa gggcctgaag      360

ctgggcatct acgccgacgt gggcaacaag acctgcgccg gcttccccgg cagcttcggc      420

tactacgaca tcgacgccca gaccttcgcc gactggggcg tggacctgct gaagttcgac      480

ggctgctact gcgacagcct ggagaacctg gccgacggct acaagcacat gagcctggcc      540

ctgaaccgca ccggccgcag catcgtgtac agctgcgagt ggcccctgta catgtggccc      600

ttccagaagc ccaactacac cgagatccgc cagtactgca accactggcg caacttcgcc      660

gacatcgacg acagctggaa gagcatcaag agcatcctgg actggaccag cttcaaccag      720

gagcgcatcg tggacgtggc cggccccggc ggctggaacg accccgacat gctggtgatc      780

ggcaacttcg gcctgagctg gaaccagcag gtgacccaga tggccctgtg ggccatcatg      840

gccgcccccc tgttcatgag caacgacctg cgccacatca gcccccaggc caaggccctg      900

ctgcaggaca aggacgtgat cgccatcaac caggaccccc tgggcaagca gggctaccag      960

ctgcgccagg gcgacaactt cgaggtgtgg gagcgccccc tgagcggcct ggcctgggcc     1020

gtggccatga tcaaccgcca ggagatcggc ggcccccgca gctacaccat cgccgtggcc     1080

agcctgggca agggcgtggc ctgcaacccc gcctgcttca tcacccagct gctgcccgtg     1140

aagcgcaagc tgggcttcta cgagtggacc agccgcctgc gcagccacat caaccccacc     1200

ggcaccgtgc tgctgcagct ggagaacacc atgcagatga gcctgaagga cctgctgggc     1260

ggcagcagcg agcccaagag cagcgacaag acccacacct gccccccctg ccccgccccc     1320

gagctgctgg gcggccccag cgtgttcctg ttccccccca agcccaagga caccctgatg     1380

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag     1440

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagccccgc     1500

gaggagcagt acaacagcac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1560

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgcccccatc     1620

gagaagacca tcagcaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1680

cccagccgcg acgagctgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1740

taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag     1800

accacccccc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1860

gacaagagcc gctggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1920

cacaaccact acacccagaa gagcctgagc ctgagccccg gcaagtaa                  1968


<210> 15
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala 
            20      


<210> 16
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctt       60

gct                                                                     63


<210> 17
<211> 6164
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgctcg acattgatta ttgactagtt      360

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta      420

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt      480

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg      540

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta      600

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga      660

ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg      720

tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa      780

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      840

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      900

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      960

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg cgctgccttc     1020

gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt     1080

tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg     1140

tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagg     1200

gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt gtgtgtgtgc gtggggagcg     1260

ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg cgggcgcggc gcggggcttt     1320

gtgcgctccg cagtgtgcgc gaggggagcg cggccggggg cggtgccccg cggtgcgggg     1380

ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg     1440

gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc ccctccccga gttgctgagc     1500

acggcccggc ttcgggtgcg gggctccgta cggggcgtgg cgcggggctc gccgtgccgg     1560

gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg     1620

gctcggggga ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc     1680

gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa     1740

tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga     1800

agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc     1860

gccgtcccct tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg     1920

ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac cggcggctct agagcctctg     1980

ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg ctggttattg     2040

tgctgtctca tcattttggc aaagaattgc aagtttgtac aaaaaagcag gctgccaccg     2100

aattcgcggc cgctaaaccc agctttcttg tacaaagtgg caactttatt atacatagtt     2160

gatcctcagg tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa tgccctggct     2220

cacaaatacc actgagatct ttttccctct gccaaaaatt atggggacat catgaagccc     2280

cttgagcatc tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg     2340

aattttttgt gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag     2400

aatgagtatt tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa     2460

ggttggctat aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc     2520

catagaaaag ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt     2580

tctttaacat ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc     2640

tgactactcc cagtcatagc tgtccctctt ctcttatgga gatccctcga cctgcagccc     2700

aagcttggat ccctcgagtt aattaacgag agcataatat tgatatgtgc caaagttgtt     2760

tctgactgac taataagtat aatttgtttc tattatgtat aggttaagct aattacttat     2820

tttataatac aacatgactg tttttaaagt acaaaataag tttatttttg taaaagagag     2880

aatgtttaaa agttttgtta ctttatagaa gaaattttga gtttttgttt ttttttaata     2940

aataaataaa cataaataaa ttgtttgttg aatttattat tagtatgtaa gtgtaaatat     3000

aataaaactt aatatctatt caaattaata aataaacctc gatatacaga ccgataaaac     3060

acatgcgtca attttacgca tgattatctt taacgtacgt cacaatatga ttatctttct     3120

agggttaaat aatagtttct aattttttta ttattcagcc tgctgtcgtg aataccgagc     3180

tccaattcgc cctatagtga gtcgtattac aattcactgg ccgtcgtttt acaacgtcgt     3240

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc     3300

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg     3360

aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     3420

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     3480

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     3540

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     3600

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     3660

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     3720

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     3780

taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc ttacaattta ggtggcactt     3840

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     3900

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     3960

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     4020

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac     4080

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg     4140

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc     4200

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg     4260

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat     4320

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg     4380

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg     4440

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc     4500

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt     4560

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct     4620

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc     4680

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca     4740

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct     4800

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     4860

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     4920

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     4980

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     5040

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     5100

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag     5160

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     5220

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     5280

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     5340

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     5400

ttcccgaaga gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     5460

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     5520

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     5580

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     5640

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     5700

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     5760

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     5820

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc     5880

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa     5940

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctcg     6000

aaattaaccc tcactaaagg gaacaaaagc tggtacctcg cgcgacttgg tttgccattc     6060

tttagcgcgc gtcgcgtcac acagcttggc cacaatgtgg tttttgtcaa acgaagattc     6120

tatgacgtgt ttaaagttta ggtcgagtaa agcgcaaatc tttt                      6164


<210> 18
<211> 1733
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
ctcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca     1440

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     1500

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc     1560

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg     1620

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1680

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttg            1733


<210> 19
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gccacc                                                                   6


<210> 20
<211> 522
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
tcctcaggtg caggctgcct atcagaaggt ggtggctggt gtggccaatg ccctggctca       60

caaataccac tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct      120

tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa      180

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa      240

tgagtatttg gtttagagtt tggcaacata tgcccatatg ctggctgcca tgaacaaagg      300

ttggctataa agaggtcatc agtatatgaa acagccccct gctgtccatt ccttattcca      360

tagaaaagcc ttgacttgag gttagatttt ttttatattt tgttttgtgt tatttttttc      420

tttaacatcc ctaaaatttt ccttacatgt tttactagcc agatttttcc tcctctcctg      480

actactccca gtcatagctg tccctcttct cttatggaga tc                         522


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ser Trp Glu Leu Tyr Tyr Pro Leu Arg Ala Asn Leu 
1               5                   10          


<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
His Ala Val Asp Ile 
1               5   


<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Asp Gly Glu Ala 
1               


<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Phe Tyr Phe Asp Leu Arg 
1               5       


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 4-hydroxyproline

<400> 25
Gly Phe Pro Gly Glu Arg 
1               5       


<210> 26
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (19)..(19)
<223> 4-hydroxyproline

<400> 26
Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
1               5                   10                  15      


Gly Phe Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro 
        35          


<210> 27
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Val Ala Pro Gly 
1               


<210> 28
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Arg Gly Asp 
1           


<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Pro Arg 
1           


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Lys Gln Ala Gly Asp Val 
1               5       


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Pro His Ser Arg Asn 
1               5   


<210> 32
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Pro His Ser Arg Asn Gly Gly Gly Gly Gly Gly Arg Gly Asp Ser 
1               5                   10                  15  


<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Arg Glu Asp Val 
1               


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Ile Lys Val Ala Val 
1               5   


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Ser Arg Ala Arg Lys Gln Ala Ala Ser Ile Lys Val Ala Val Ala Asp 
1               5                   10                  15      


Arg 
    


<210> 36
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Leu Arg Glu 
1           


<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Lys Gln Leu Arg Glu Gln 
1               5       


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Tyr Ile Gly Ser Arg 
1               5   


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Ser Val Val Tyr Gly Leu Arg 
1               5           


<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Ala Glu Ile Asp Gly Ile Glu Leu 
1               5               


<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Val Thr Cys Gly 
1               


<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Ser Val Thr Cys Gly 
1               5   


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Arg Gly Asp 
1               


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Arg Gly Asp Ser Pro 
1               5       


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gly Gly Arg Gly Asp Ser Pro 
1               5           


<210> 46
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gly Gly Gly Arg Gly Asp Ser Pro 
1               5               


<210> 47
<211> 4347
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgctcg acattgatta ttgactagtt      360

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta      420

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt      480

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg      540

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta      600

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga      660

ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg      720

tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa      780

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      840

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      900

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      960

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg cgctgccttc     1020

gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt     1080

tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg     1140

tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagg     1200

gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt gtgtgtgtgc gtggggagcg     1260

ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg cgggcgcggc gcggggcttt     1320

gtgcgctccg cagtgtgcgc gaggggagcg cggccggggg cggtgccccg cggtgcgggg     1380

ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg     1440

gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc ccctccccga gttgctgagc     1500

acggcccggc ttcgggtgcg gggctccgta cggggcgtgg cgcggggctc gccgtgccgg     1560

gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg     1620

gctcggggga ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc     1680

gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa     1740

tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga     1800

agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc     1860

gccgtcccct tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg     1920

ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac cggcggctct agagcctctg     1980

ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg ctggttattg     2040

tgctgtctca tcattttggc aaagaattgc aagtttgtac aaaaaagcag gctgccacca     2100

tgggctggcg agctgctggt gcacttctgc tggctctgct gcttcatggc agactgcttg     2160

ctctggacaa cggcctggcc cgcaccccca ccatgggctg gctgcactgg gagcgcttca     2220

tgtgcaacct ggactgccag gaggagcccg acagctgcat cagcgagaag ctgttcatgg     2280

agatggccga gctgatggtg agcgagggct ggaaggacgc cggctacgag tacctgtgca     2340

tcgacgactg ctggatggcc ccccagcgcg acagcgaggg ccgcctgcag gccgaccccc     2400

agcgcttccc ccacggcatc cgccagctgg ccaactacgt gcacagcaag ggcctgaagc     2460

tgggcatcta cgccgacgtg ggcaacaaga cctgcgccgg cttccccggc agcttcggct     2520

actacgacat cgacgcccag accttcgccg actggggcgt ggacctgctg aagttcgacg     2580

gctgctactg cgacagcctg gagaacctgg ccgacggcta caagcacatg agcctggccc     2640

tgaaccgcac cggccgcagc atcgtgtaca gctgcgagtg gcccctgtac atgtggccct     2700

tccagaagcc caactacacc gagatccgcc agtactgcaa ccactggcgc aacttcgccg     2760

acatcgacga cagctggaag agcatcaaga gcatcctgga ctggaccagc ttcaaccagg     2820

agcgcatcgt ggacgtggcc ggccccggcg gctggaacga ccccgacatg ctggtgatcg     2880

gcaacttcgg cctgagctgg aaccagcagg tgacccagat ggccctgtgg gccatcatgg     2940

ccgcccccct gttcatgagc aacgacctgc gccacatcag cccccaggcc aaggccctgc     3000

tgcaggacaa ggacgtgatc gccatcaacc aggaccccct gggcaagcag ggctaccagc     3060

tgcgccaggg cgacaacttc gaggtgtggg agcgccccct gagcggcctg gcctgggccg     3120

tggccatgat caaccgccag gagatcggcg gcccccgcag ctacaccatc gccgtggcca     3180

gcctgggcaa gggcgtggcc tgcaaccccg cctgcttcat cacccagctg ctgcccgtga     3240

agcgcaagct gggcttctac gagtggacca gccgcctgcg cagccacatc aaccccaccg     3300

gcaccgtgct gctgcagctg gagaacacca tgcagatgag cctgaaggac ctgctgtaac     3360

aactttatta tacatagttg atcctcaggt gcaggctgcc tatcagaagg tggtggctgg     3420

tgtggccaat gccctggctc acaaatacca ctgagatctt tttccctctg ccaaaaatta     3480

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3540

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc     3600

aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccatat     3660

gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga aacagccccc     3720

tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt     3780

ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc     3840

cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc tcttatggag     3900

atccctcgac ctgcagccca agcttggatc cctcgagtta attaacgaga gcataatatt     3960

gatatgtgcc aaagttgttt ctgactgact aataagtata atttgtttct attatgtata     4020

ggttaagcta attacttatt ttataataca acatgactgt ttttaaagta caaaataagt     4080

ttatttttgt aaaagagaga atgtttaaaa gttttgttac tttatagaag aaattttgag     4140

tttttgtttt tttttaataa ataaataaac ataaataaat tgtttgttga atttattatt     4200

agtatgtaag tgtaaatata ataaaactta atatctattc aaattaataa ataaacctcg     4260

atatacagac cgataaaaca catgcgtcaa ttttacgcat gattatcttt aacgtacgtc     4320

acaatatgat tatctttcta gggttaa                                         4347


<210> 48
<211> 7383
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 48
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgctcg acattgatta ttgactagtt      360

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta      420

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt      480

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg      540

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta      600

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga      660

ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg      720

tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa      780

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      840

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      900

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      960

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg cgctgccttc     1020

gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt     1080

tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg     1140

tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagg     1200

gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt gtgtgtgtgc gtggggagcg     1260

ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg cgggcgcggc gcggggcttt     1320

gtgcgctccg cagtgtgcgc gaggggagcg cggccggggg cggtgccccg cggtgcgggg     1380

ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg     1440

gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc ccctccccga gttgctgagc     1500

acggcccggc ttcgggtgcg gggctccgta cggggcgtgg cgcggggctc gccgtgccgg     1560

gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg     1620

gctcggggga ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc     1680

gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa     1740

tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga     1800

agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc     1860

gccgtcccct tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg     1920

ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac cggcggctct agagcctctg     1980

ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg ctggttattg     2040

tgctgtctca tcattttggc aaagaattgc aagtttgtac aaaaaagcag gctgccacca     2100

tgggctggcg agctgctggt gcacttctgc tggctctgct gcttcatggc agactgcttg     2160

ctctggacaa cggcctggcc cgcaccccca ccatgggctg gctgcactgg gagcgcttca     2220

tgtgcaacct ggactgccag gaggagcccg acagctgcat cagcgagaag ctgttcatgg     2280

agatggccga gctgatggtg agcgagggct ggaaggacgc cggctacgag tacctgtgca     2340

tcgacgactg ctggatggcc ccccagcgcg acagcgaggg ccgcctgcag gccgaccccc     2400

agcgcttccc ccacggcatc cgccagctgg ccaactacgt gcacagcaag ggcctgaagc     2460

tgggcatcta cgccgacgtg ggcaacaaga cctgcgccgg cttccccggc agcttcggct     2520

actacgacat cgacgcccag accttcgccg actggggcgt ggacctgctg aagttcgacg     2580

gctgctactg cgacagcctg gagaacctgg ccgacggcta caagcacatg agcctggccc     2640

tgaaccgcac cggccgcagc atcgtgtaca gctgcgagtg gcccctgtac atgtggccct     2700

tccagaagcc caactacacc gagatccgcc agtactgcaa ccactggcgc aacttcgccg     2760

acatcgacga cagctggaag agcatcaaga gcatcctgga ctggaccagc ttcaaccagg     2820

agcgcatcgt ggacgtggcc ggccccggcg gctggaacga ccccgacatg ctggtgatcg     2880

gcaacttcgg cctgagctgg aaccagcagg tgacccagat ggccctgtgg gccatcatgg     2940

ccgcccccct gttcatgagc aacgacctgc gccacatcag cccccaggcc aaggccctgc     3000

tgcaggacaa ggacgtgatc gccatcaacc aggaccccct gggcaagcag ggctaccagc     3060

tgcgccaggg cgacaacttc gaggtgtggg agcgccccct gagcggcctg gcctgggccg     3120

tggccatgat caaccgccag gagatcggcg gcccccgcag ctacaccatc gccgtggcca     3180

gcctgggcaa gggcgtggcc tgcaaccccg cctgcttcat cacccagctg ctgcccgtga     3240

agcgcaagct gggcttctac gagtggacca gccgcctgcg cagccacatc aaccccaccg     3300

gcaccgtgct gctgcagctg gagaacacca tgcagatgag cctgaaggac ctgctgtaac     3360

aactttatta tacatagttg atcctcaggt gcaggctgcc tatcagaagg tggtggctgg     3420

tgtggccaat gccctggctc acaaatacca ctgagatctt tttccctctg ccaaaaatta     3480

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3540

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc     3600

aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccatat     3660

gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga aacagccccc     3720

tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt     3780

ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc     3840

cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc tcttatggag     3900

atccctcgac ctgcagccca agcttggatc cctcgagtta attaacgaga gcataatatt     3960

gatatgtgcc aaagttgttt ctgactgact aataagtata atttgtttct attatgtata     4020

ggttaagcta attacttatt ttataataca acatgactgt ttttaaagta caaaataagt     4080

ttatttttgt aaaagagaga atgtttaaaa gttttgttac tttatagaag aaattttgag     4140

tttttgtttt tttttaataa ataaataaac ataaataaat tgtttgttga atttattatt     4200

agtatgtaag tgtaaatata ataaaactta atatctattc aaattaataa ataaacctcg     4260

atatacagac cgataaaaca catgcgtcaa ttttacgcat gattatcttt aacgtacgtc     4320

acaatatgat tatctttcta gggttaaata atagtttcta atttttttat tattcagcct     4380

gctgtcgtga ataccgagct ccaattcgcc ctatagtgag tcgtattaca attcactggc     4440

cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc     4500

agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     4560

ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc     4620

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     4680

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     4740

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     4800

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     4860

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     4920

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg     4980

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct     5040

tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     5100

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     5160

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt     5220

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct     5280

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc     5340

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta     5400

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac     5460

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc     5520

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac     5580

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg     5640

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac     5700

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc     5760

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt     5820

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga     5880

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc     5940

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag     6000

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca     6060

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc     6120

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     6180

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     6240

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     6300

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt     6360

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     6420

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     6480

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     6540

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     6600

ctatgagaaa gcgccacgct tcccgaagag agaaaggcgg acaggtatcc ggtaagcggc     6660

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     6720

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     6780

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc     6840

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt     6900

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca     6960

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg     7020

attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac     7080

gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg     7140

gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac     7200

catgattacg ccaagctcga aattaaccct cactaaaggg aacaaaagct ggtacctcgc     7260

gcgacttggt ttgccattct ttagcgcgcg tcgcgtcaca cagcttggcc acaatgtggt     7320

ttttgtcaaa cgaagattct atgacgtgtt taaagtttag gtcgagtaaa gcgcaaatct     7380

ttt                                                                   7383


<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Arg Gly Asp Ser Pro 
1               5   


<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(3)
<223> This region may encompass 1-3 residues

<400> 50
Gly Gly Gly Arg Gly Asp 
1               5       


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(3)
<223> This region may encompass 1-3 residues

<400> 51
Gly Gly Gly Arg Gly Asp Ser Pro 
1               5               


