                         SEQUENCE LISTING

<110>  Orionis Biosciences, Inc.
       Orionis Biosciences BV
       Kley, Nikolai
       Tavernier, Jan
       Depla, Erik
       Zabeau, Lennart
 
<120>  CHIMERIC PROTEINS AND CHIMERIC PROTEIN COMPLEXES DIRECTED TO 
       FMS-LIKE TYROSINE KINASE 3 (FLT3)

<130>  ORN-062PC_B/114384/5062

<150>  US 62/825,580
<151>  2019-03-28

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  2
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro 
145                 150                 155             


<210>  3
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala 
145                 150                 155 


<210>  4
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro 
    130                 


<210>  5
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 
1               5                   10                  15      


Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 
            20                  25                  30          


Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 
        35                  40                  45              


Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 
    50                  55                  60                  


Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 
65                  70                  75                  80  


Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 
                85                  90                  95      


Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu 
            100                 105                 110         


Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 
        115                 120                 125             


Cys 
    


<210>  6
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  7
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Trp Arg Ala 
    130                 135                 140                 


Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu 
145                 150                 155                 160 


Arg Ser Lys Glu 
                


<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10

Gly Gly Gly Gly Ser 
1               5   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  16
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  17
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18

Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  21

Glu Ala Ala Ala Lys 
1               5   


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  22

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  23

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  25

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  26

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala 
            20          


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  27

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


<210>  28
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  28

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  29

Pro Ala Pro Ala Pro 
1               5   


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  30

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  31

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  32

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33

Gly Gly Gly Ser Glu 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  34

Gly Ser Glu Ser Gly 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35

Gly Ser Glu Gly Ser 
1               5   


<210>  36
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser Ser Ser 
1               5                   10                  15      


Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37

Cys Pro Pro Cys 
1               


<210>  38
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  38

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  39
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  39

Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln Lys 
1               5                   10                  15      


Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu Gln 
            20                  25                  30          


Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu 
        115                 120                 125             


Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210>  40
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  40

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            180                 185                 190         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        195                 200                 205             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  41
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  41

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            260                 265                 270         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 
        275                 280                 285             


Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu 
    290                 295                 300                 


Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg 
305                 310                 315                 320 


His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys 
                325                 330                 335     


Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn 
            340                 345                 350         


Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu 
        355                 360                 365             


Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala 
    370                 375                 380                 


Cys Val Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu 
385                 390                 395                 400 


Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr 
                405                 410                 415     


Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala 
            420                 425                 430         


Glu Ile Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu 
        435                 440                 445             


Arg Ser Lys Glu 
    450         


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  42

Cys Pro Pro Cys 
1               


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  43

Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  44

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  45

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  


<210>  46
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  46

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
305                 310                 315                 320 


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys 
    


<210>  47
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  47

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        435                 440                 445             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp Leu 
    450                 455                 460                 


Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala 
465                 470                 475                 480 


Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp 
                485                 490                 495     


Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu 
            500                 505                 510         


Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe 
        515                 520                 525             


Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys 
    530                 535                 540                 


Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val 
545                 550                 555                 560 


Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp Ser 
                565                 570                 575     


Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys 
            580                 585                 590         


Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile 
        595                 600                 605             


Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser 
    610                 615                 620                 


Lys Glu 
625     


<210>  48
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  48

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Asp 
145                 150                 155                 160 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            180                 185                 190         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        195                 200                 205             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    210                 215                 220                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
225                 230                 235                 240 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                245                 250                 255     


Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            260                 265                 270         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
        275                 280                 285             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    290                 295                 300                 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
305                 310                 315                 320 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        355                 360                 365             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    370                 375                 380                 


Gly Lys 
385     


<210>  49
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  49

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Asp 
145                 150                 155                 160 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            180                 185                 190         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        195                 200                 205             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    210                 215                 220                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
225                 230                 235                 240 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                245                 250                 255     


Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            260                 265                 270         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        275                 280                 285             


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    290                 295                 300                 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
305                 310                 315                 320 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        355                 360                 365             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    370                 375                 380                 


Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp 
        435                 440                 445             


Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu 
    450                 455                 460                 


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
465                 470                 475                 480 


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala 
                485                 490                 495     


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
            500                 505                 510         


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
        515                 520                 525             


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
    530                 535                 540                 


Val Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp 
545                 550                 555                 560 


Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu 
                565                 570                 575     


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
            580                 585                 590         


Ile Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
        595                 600                 605             


Ser Lys Glu 
    610     


<210>  50
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  50

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
145                 150                 155                 160 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                165                 170                 175     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            180                 185                 190         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        195                 200                 205             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    210                 215                 220                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
225                 230                 235                 240 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala 
                245                 250                 255     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            260                 265                 270         


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        275                 280                 285             


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
    290                 295                 300                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375     


<210>  51
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  51

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
145                 150                 155                 160 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                165                 170                 175     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            180                 185                 190         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        195                 200                 205             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    210                 215                 220                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
225                 230                 235                 240 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala 
                245                 250                 255     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            260                 265                 270         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        275                 280                 285             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    290                 295                 300                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                405                 410                 415     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            420                 425                 430         


Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg 
        435                 440                 445             


Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser 
    450                 455                 460                 


Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly 
465                 470                 475                 480 


Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile 
                485                 490                 495     


Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp 
            500                 505                 510         


Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu 
        515                 520                 525             


Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Glu Glu Thr 
    530                 535                 540                 


Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln 
545                 550                 555                 560 


Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
                565                 570                 575     


Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe Ser Leu Ser Thr Asn 
            580                 585                 590         


Leu Gln Glu Ser Leu Arg Ser Lys Glu 
        595                 600     


<210>  52
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  52

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
305                 310                 315                 320 


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys 
    


<210>  53
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  53

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        435                 440                 445             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp Leu 
    450                 455                 460                 


Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala 
465                 470                 475                 480 


Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp 
                485                 490                 495     


Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu 
            500                 505                 510         


Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe 
        515                 520                 525             


Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys 
    530                 535                 540                 


Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val 
545                 550                 555                 560 


Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp Ser 
                565                 570                 575     


Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys 
            580                 585                 590         


Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile 
        595                 600                 605             


Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser 
    610                 615                 620                 


Lys Glu 
625     


<210>  54
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  54

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Asp 
145                 150                 155                 160 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            180                 185                 190         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        195                 200                 205             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    210                 215                 220                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
225                 230                 235                 240 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                245                 250                 255     


Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            260                 265                 270         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
        275                 280                 285             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    290                 295                 300                 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
305                 310                 315                 320 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        355                 360                 365             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    370                 375                 380                 


Gly Lys 
385     


<210>  55
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  55

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Ser Asp 
145                 150                 155                 160 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            180                 185                 190         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        195                 200                 205             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    210                 215                 220                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
225                 230                 235                 240 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                245                 250                 255     


Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            260                 265                 270         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        275                 280                 285             


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    290                 295                 300                 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
305                 310                 315                 320 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        355                 360                 365             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    370                 375                 380                 


Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp 
        435                 440                 445             


Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu 
    450                 455                 460                 


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
465                 470                 475                 480 


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala 
                485                 490                 495     


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
            500                 505                 510         


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
        515                 520                 525             


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
    530                 535                 540                 


Val Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp 
545                 550                 555                 560 


Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu 
                565                 570                 575     


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
            580                 585                 590         


Ile Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
        595                 600                 605             


Ser Lys Glu 
    610     


<210>  56
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  56

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
145                 150                 155                 160 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                165                 170                 175     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            180                 185                 190         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        195                 200                 205             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    210                 215                 220                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
225                 230                 235                 240 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala 
                245                 250                 255     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            260                 265                 270         


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        275                 280                 285             


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
    290                 295                 300                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375     


<210>  57
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  57

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
145                 150                 155                 160 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                165                 170                 175     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            180                 185                 190         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        195                 200                 205             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    210                 215                 220                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
225                 230                 235                 240 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala 
                245                 250                 255     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            260                 265                 270         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        275                 280                 285             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    290                 295                 300                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                405                 410                 415     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            420                 425                 430         


Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg 
        435                 440                 445             


Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser 
    450                 455                 460                 


Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly 
465                 470                 475                 480 


Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile 
                485                 490                 495     


Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp 
            500                 505                 510         


Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu 
        515                 520                 525             


Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Glu Glu Thr 
    530                 535                 540                 


Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln 
545                 550                 555                 560 


Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
                565                 570                 575     


Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe Ser Leu Ser Thr Asn 
            580                 585                 590         


Leu Gln Glu Ser Leu Arg Ser Lys Glu 
        595                 600     


<210>  58
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  58

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro 
                165                 170                 175     


Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 
            180                 185                 190         


Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 
        195                 200                 205             


Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 
    210                 215                 220                 


Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 
225                 230                 235                 240 


Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 
                245                 250                 255     


Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln 
            260                 265                 270         


Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln 
        275                 280                 285             


Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr 
305                 310                 315                 320 


Ala Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                325                 330                 335     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            340                 345                 350         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
        355                 360                 365             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    370                 375                 380                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
385                 390                 395                 400 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                405                 410                 415     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            420                 425                 430         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        435                 440                 445             


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    450                 455                 460                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
465                 470                 475                 480 


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                485                 490                 495     


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            500                 505                 510         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        515                 520                 525             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
    530                 535                 540                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
545                 550                 555                 560 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                565                 570                 575     


Pro Gly Lys 
            


<210>  59
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  59

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            260                 265                 270         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 
        275                 280                 285             


Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu 
    290                 295                 300                 


Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg 
305                 310                 315                 320 


His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys 
                325                 330                 335     


Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn 
            340                 345                 350         


Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu 
        355                 360                 365             


Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala 
    370                 375                 380                 


Cys Val Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu 
385                 390                 395                 400 


Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr 
                405                 410                 415     


Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala 
            420                 425                 430         


Glu Ile Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu 
        435                 440                 445             


Arg Ser Lys Glu 
    450         


<210>  60
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  60

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser 
                165                 170                 175     


Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 
            180                 185                 190         


Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 
        195                 200                 205             


Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 
    210                 215                 220                 


Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
225                 230                 235                 240 


Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 
                245                 250                 255     


Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 
            260                 265                 270         


Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 
        275                 280                 285             


Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 
    290                 295                 300                 


Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Pro Thr Ala Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            340                 345                 350         


Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        355                 360                 365             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala 
    450                 455                 460                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                485                 490                 495     


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
    530                 535                 540                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     


Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 


<210>  61
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  61

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser 
                165                 170                 175     


Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 
            180                 185                 190         


Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 
        195                 200                 205             


Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 
    210                 215                 220                 


Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
225                 230                 235                 240 


Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 
                245                 250                 255     


Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 
            260                 265                 270         


Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 
        275                 280                 285             


Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 
    290                 295                 300                 


Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Pro Thr Ala Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            340                 345                 350         


Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        355                 360                 365             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala 
    450                 455                 460                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                485                 490                 495     


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
    530                 535                 540                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     


Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 


<210>  62
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  62

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro 
                165                 170                 175     


Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 
            180                 185                 190         


Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 
        195                 200                 205             


Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 
    210                 215                 220                 


Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 
225                 230                 235                 240 


Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 
                245                 250                 255     


Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln 
            260                 265                 270         


Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln 
        275                 280                 285             


Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys Thr His Thr 
            340                 345                 350         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        355                 360                 365             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    370                 375                 380                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
385                 390                 395                 400 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                405                 410                 415     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            420                 425                 430         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        435                 440                 445             


Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    450                 455                 460                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
465                 470                 475                 480 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
                485                 490                 495     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            500                 505                 510         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        515                 520                 525             


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    530                 535                 540                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
545                 550                 555                 560 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570                 


<210>  63
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  63

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro 
                165                 170                 175     


Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 
            180                 185                 190         


Asp Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 
        195                 200                 205             


Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 
    210                 215                 220                 


Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 
225                 230                 235                 240 


Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 
                245                 250                 255     


Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln 
            260                 265                 270         


Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln 
        275                 280                 285             


Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys Thr His Thr 
            340                 345                 350         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        355                 360                 365             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    370                 375                 380                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
385                 390                 395                 400 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                405                 410                 415     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            420                 425                 430         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        435                 440                 445             


Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    450                 455                 460                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
465                 470                 475                 480 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
                485                 490                 495     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            500                 505                 510         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        515                 520                 525             


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    530                 535                 540                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
545                 550                 555                 560 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570                 


<210>  64
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  64

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 
145                 150                 155                 160 


Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 
                165                 170                 175     


Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 
            180                 185                 190         


Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 
        195                 200                 205             


Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 
    210                 215                 220                 


Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 
225                 230                 235                 240 


Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 
                245                 250                 255     


Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 
            260                 265                 270         


Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    290                 295                 300                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
305                 310                 315                 320 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                325                 330                 335     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            340                 345                 350         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        355                 360                 365             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    370                 375                 380                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
385                 390                 395                 400 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val 
                405                 410                 415     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            420                 425                 430         


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
        435                 440                 445             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
    450                 455                 460                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
465                 470                 475                 480 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                485                 490                 495     


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            500                 505                 510         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        515                 520                 525             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535                 540 


<210>  65
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  65

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 
145                 150                 155                 160 


Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp 
                165                 170                 175     


Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 
            180                 185                 190         


Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 
        195                 200                 205             


Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 
    210                 215                 220                 


Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 
225                 230                 235                 240 


Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 
                245                 250                 255     


Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 
            260                 265                 270         


Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    290                 295                 300                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
305                 310                 315                 320 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                325                 330                 335     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            340                 345                 350         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        355                 360                 365             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    370                 375                 380                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
385                 390                 395                 400 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Gln Val 
                405                 410                 415     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            420                 425                 430         


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
        435                 440                 445             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
    450                 455                 460                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
465                 470                 475                 480 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                485                 490                 495     


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            500                 505                 510         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        515                 520                 525             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535                 540 


<210>  66
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  66

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            260                 265                 270         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 
        275                 280                 285             


Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu 
    290                 295                 300                 


Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg 
305                 310                 315                 320 


His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys 
                325                 330                 335     


Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn 
            340                 345                 350         


Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu 
        355                 360                 365             


Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala 
    370                 375                 380                 


Cys Val Ile Gln Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu 
385                 390                 395                 400 


Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr 
                405                 410                 415     


Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala 
            420                 425                 430         


Glu Ile Met Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu 
        435                 440                 445             


Arg Ser Lys Glu 
    450         


<210>  67
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  67

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser 
                165                 170                 175     


Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 
            180                 185                 190         


Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 
        195                 200                 205             


Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 
    210                 215                 220                 


Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
225                 230                 235                 240 


Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 
                245                 250                 255     


Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 
            260                 265                 270         


Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 
        275                 280                 285             


Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 
    290                 295                 300                 


Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Pro Thr Ala Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            340                 345                 350         


Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        355                 360                 365             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe 
    370                 375                 380                 


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
385                 390                 395                 400 


Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met 
                405                 410                 415     


Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala 
            420                 425                 430         


Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln 
        435                 440                 445             


Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Glu Glu 
    450                 455                 460                 


Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe 
465                 470                 475                 480 


Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala 
                485                 490                 495     


Trp Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe Ser Leu Ser Thr 
            500                 505                 510         


Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
        515                 520         


<210>  68
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  68

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser 
                165                 170                 175     


Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 
            180                 185                 190         


Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 
        195                 200                 205             


Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 
    210                 215                 220                 


Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
225                 230                 235                 240 


Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 
                245                 250                 255     


Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 
            260                 265                 270         


Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 
        275                 280                 285             


Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 
    290                 295                 300                 


Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Pro Thr Ala Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            340                 345                 350         


Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        355                 360                 365             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe 
    370                 375                 380                 


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
385                 390                 395                 400 


Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met 
                405                 410                 415     


Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala 
            420                 425                 430         


Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln 
        435                 440                 445             


Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Glu Glu 
    450                 455                 460                 


Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe 
465                 470                 475                 480 


Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala 
                485                 490                 495     


Trp Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe Ser Leu Ser Thr 
            500                 505                 510         


Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
        515                 520         


<210>  69
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  69

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro 
                165                 170                 175     


Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 
            180                 185                 190         


Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 
        195                 200                 205             


Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 
    210                 215                 220                 


Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 
225                 230                 235                 240 


Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 
                245                 250                 255     


Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln 
            260                 265                 270         


Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln 
        275                 280                 285             


Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln 
            340                 345                 350         


Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met 
        355                 360                 365             


Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly 
    370                 375                 380                 


Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile 
385                 390                 395                 400 


Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr 
                405                 410                 415     


Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr 
            420                 425                 430         


Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln 
        435                 440                 445             


Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu 
    450                 455                 460                 


Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys 
465                 470                 475                 480 


Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Ala 
                485                 490                 495     


Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            500                 505                 510         


<210>  70
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  70

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro 
                165                 170                 175     


Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 
            180                 185                 190         


Asp Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 
        195                 200                 205             


Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 
    210                 215                 220                 


Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 
225                 230                 235                 240 


Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 
                245                 250                 255     


Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln 
            260                 265                 270         


Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln 
        275                 280                 285             


Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln 
            340                 345                 350         


Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met 
        355                 360                 365             


Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly 
    370                 375                 380                 


Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile 
385                 390                 395                 400 


Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr 
                405                 410                 415     


Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr 
            420                 425                 430         


Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln 
        435                 440                 445             


Gly Val Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu 
    450                 455                 460                 


Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys 
465                 470                 475                 480 


Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Ala 
                485                 490                 495     


Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            500                 505                 510         


<210>  71
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  71

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 
145                 150                 155                 160 


Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 
                165                 170                 175     


Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 
            180                 185                 190         


Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 
        195                 200                 205             


Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 
    210                 215                 220                 


Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 
225                 230                 235                 240 


Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 
                245                 250                 255     


Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 
            260                 265                 270         


Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    290                 295                 300                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His 
305                 310                 315                 320 


Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys 
                325                 330                 335     


Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro 
            340                 345                 350         


Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val 
        355                 360                 365             


Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp 
    370                 375                 380                 


Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu 
385                 390                 395                 400 


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val 
                405                 410                 415     


Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val 
            420                 425                 430         


Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr 
        435                 440                 445             


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe 
    450                 455                 460                 


Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
465                 470                 475             


<210>  72
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  72

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 
145                 150                 155                 160 


Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Asp 
                165                 170                 175     


Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 
            180                 185                 190         


Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 
        195                 200                 205             


Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 
    210                 215                 220                 


Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 
225                 230                 235                 240 


Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 
                245                 250                 255     


Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 
            260                 265                 270         


Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Gly Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    290                 295                 300                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His 
305                 310                 315                 320 


Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys 
                325                 330                 335     


Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro 
            340                 345                 350         


Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val 
        355                 360                 365             


Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp 
    370                 375                 380                 


Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu 
385                 390                 395                 400 


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val 
                405                 410                 415     


Gly Val Glu Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val 
            420                 425                 430         


Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr 
        435                 440                 445             


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe 
    450                 455                 460                 


Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
465                 470                 475             


<210>  73
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  73

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Val Asp Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Arg 
                165                 170                 175     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            180                 185                 190         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        195                 200                 205             


Gly Ser Gly Gly Ser Gly Gly Ser Ala Ala Ala Met Cys Asp Leu Pro 
    210                 215                 220                 


Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln 
225                 230                 235                 240 


Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe 
                245                 250                 255     


Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr 
            260                 265                 270         


Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser 
        275                 280                 285             


Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe 
    290                 295                 300                 


Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile 
305                 310                 315                 320 


Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile 
                325                 330                 335     


Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu 
            340                 345                 350         


Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met 
        355                 360                 365             


Ala Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys 
    370                 375                 380                 


Glu 
385 


<210>  74
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  74

Cys Asp Leu Pro Glu Thr His Ser Leu Asp Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Ser Arg Ile Ser Pro Ser Ser Cys Leu Met Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Pro Ala Ile Ser Val Leu His Glu Leu Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Asp 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Ala Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


