                         SEQUENCE LISTING

<110>  Kaunitz, Jonathan D.
       Akiba, Yasutada
       Oh, Suwan
 
<120>  Compositions and Methods of Treating and Preventing Systemic 
       Complications of Acute Illness

<130>  37759.0168P1

<150>  US 62/825,087
<151>  2019-03-28

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Arg 
        


<210>  3
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  4
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Tyr Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  5
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  6
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

His Val Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  8
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Ala Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  9
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D configuration

<400>  9

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Ala Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

His Gly Ala Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

His Gly Asp Ala Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  13
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

His Ala Glu Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  14
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

His Ala Asp Ala Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  15
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Ile13=desIle

<400>  15

His Ala Asp Gly Ser Phe Ser Asp Tyr Ser Lys Tyr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  16
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

His Ala Asp Gly Ser Phe Ser Asp Glu Leu Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  17
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Norleucine

<400>  17

His Ala Asp Gly Ser Phe Ser Asp Glu Leu Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  18
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  SULFATATION

<400>  18

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Lys Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  20
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Val Gln Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  AMIDATION

<400>  21

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  22
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  23
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic cosntruct

<400>  23

His Gly Asp Gly Ser Phe Ser Ala Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  24
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

His Gly Asp Gly Ser Phe Ser Asp Glu Met Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  25
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Ala Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  26
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

His Gly Asp Gly Ser Phe Ser Asp Ala Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  28
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Ala Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  29
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  30
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

His Gly Asp Gly Ala Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ala Thr 
            20                  25                  30          


Asp 
    


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ala Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  33
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Ala Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  34
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ala Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  35
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

His Gly Asp Gly Ser Phe Ala Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  36
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

His Gly Asp Gly Ser Ala Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  37
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  38
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D configuration

<400>  38

His Gly Asp Gly Ser Phe Ser Asp Glu Leu Phe Thr Ile Leu Asp Leu 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

His Gly Glu Gly Thr Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210>  40
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

His Gly Asp Gly Ser Phe Ser Asp Glu Ala Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D configuration

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  41

His Phe Asp Ala Val Phe Thr Asn Ser Tyr Arg Lys Val Leu Lys Arg 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Leu 
            20                  25          


