                         SEQUENCE LISTING

<110>  Thomas Jefferson University
       Andrews, David W.
       Hooper, Douglas C.
 
<120>  Methods for Treating Cancers Using Antisense

<130>  205961-5009-00WO

<150>  US 62/825,516
<151>  2019-03-28

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOBEL phosphorothioate AS ODN


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  May be joined by a phosphorothioate linkage

<400>  1
tcctccggag ccagactt                                                     18


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  2
ttctccactc gtcggcc                                                      17


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  3
acaggccgtg tcgttgtc                                                     18


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  4
gcactcgccg tcgtggat                                                     18


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  5
cggatatggt cgttctcc                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  6
tctcagcctc gtggttgc                                                     18


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  7
ttgcggcctc gttcactg                                                     18


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  8
aagcttcgtt gagaaact                                                     18


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  9
ggacttgctc gttggaca                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  10
ggctgtctct cgtcgaag                                                     18


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDT1220 phosphorothioate AS ODN


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  May be joined by a phosphorothioate linkage

<400>  11
cagatttctc cactcgtcgg                                                   20


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  12
ccggagccag acttcat                                                      17


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  13
ctgctcctcc tctaggatga                                                   20


<210>  14
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Insulin-like Growth Factor Receptor (IGF-1R) 
       antisense oligodeoxynucleotide (AS-ODN)

<400>  14
ccctcctccg gagcc                                                        15


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DWA phosphorothioate AS ODN


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  May be joined by a phosphorothioate linkage

<400>  15
ggaccctcct ccggagcc                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DWA locked nucleic acid AS ODN


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  May be joined by a locked nucleic acid linkage

<220>
<221>  misc_feature
<222>  (6)..(13)
<223>  May be joined by a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  May be joined by a locked nucleic acid linkage

<400>  16
ggaccctcct ccggagcc                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DWA phosphodiester AS ODN


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  May be joined by a phosphodiester linkage

<400>  17
ggaccctcct ccggagcc                                                     18


<210>  18
<211>  927
<212>  RNA
<213>  Homo sapiens

<400>  18
cuuuguuuuc uuuucuuccu cacagaccuu cgggcaagga ccuucacaag ggaugcagua       60

caugcucugg cugccguugc ggaugaagcc cgaggggcac uccugcaugc acucgccguc      120

guggaucaca aaccccucgg agucgcugcu cucggcgcug aggauguugg cgcagaaguc      180

acgguccaca cagcgccagc ccucaaaccu guagguguug ggcgggcagg caggcacaca      240

gacaccggca uaguaguagu ggcggcaagc uacacaggcc gugucguugu caggcgcgcu      300

gcagcugccc aggcacucgg gguggcagca cucauuguuc ucggugcacg cccgcuuccc      360

acacgugcuu gggcacauuu ucuggcagcg guuugugguc cagcagcggu aguuguacuc      420

auuguugaug guggucuucu cacacaucgg cuucuccucc auggucccug gacacagguc      480

cccacauucc uuugggggcu uauuccccac aauguaguua uuggacaccg cauccaggau      540

cagggaccag uccacagugg agagguaaca gaggucagca uuuuucacaa uccugauggc      600

cccccgagua auguuccuca gguuguaaag cccaauaucc uugagauugg ucaucucgaa      660

gaugaccagg gcguaguugu agaagaguuu ccagccgcgg augaccguga gguuggggaa      720

gaggucuccg aggcucucga ggccagccac ucggaacagc agcaaguacu cgguaaugac      780

cgugagcuug gggaagcggu agcugcggua guccucggcc uuggagauga gcaggaugug      840

gagguagccc ucgaucaccg ugcaguucuc caggcgcuuc agcugcugau agucguugcg      900

gaugucgaug ccuggcccgc agauuuc                                          927


<210>  19
<211>  4104
<212>  DNA
<213>  Homo sapiens

<400>  19
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttca tccatctgat catcgctctg     2820

cccgtcgctg tcctgttgat cgtgggaggg ttggtgatta tgctgtacgt cttccataga     2880

aagagaaata acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac     2940

ttcagcgctg ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc     3000

atgagccggg aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt     3060

gtggtgaaag atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc     3120

atgcgtgaga ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac     3180

catgtggtgc gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa     3240

ctgatgacac ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat     3300

aatccagtcc tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca     3360

gacggcatgg catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat     3420

tgcatggtag ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc     3480

tatgagacag actattaccg gaaaggaggg aaagggctgc tgcccgtgcg ctggatgtct     3540

cctgagtccc tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc     3600

gtcctctggg agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa     3660

gtccttcgct tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg     3720

ctgtttgaac tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg     3780

gagatcatca gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac     3840

tacagcgagg agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg     3900

gagagcgtcc ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac     3960

tcaggacaca aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc     4020

gacgagagac agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg     4080

ctgccccagt cttcgacctg ctga                                            4104


