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<110>  The Penn State Research Foundation
 
<120>  METHODS AND MATERIALS FOR TREATING CANCER

<130>  14017-0091WO1

<150>  US 62/823,702
<151>  2019-03-26

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Thr Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  2
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Asp Val 
1               5                   10                  15      


Leu Val Leu Leu Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro 
            20                  25                  30          


Leu Ser Ser Ser Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser 
        35                  40                  45              


Gly Gly Ala Arg Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg 
    50                  55                  60                  


Gly Gly Val Ala Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu 
65                  70                  75                  80  


Gly Leu Val His Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val 
                85                  90                  95      


Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 
            100                 105                 110         


Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 
        115                 120                 125             


Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 
    130                 135                 140                 


Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 
145                 150                 155                 160 


Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu 
            180                 185                 190         


Ser Pro Gly Gly Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro 
        195                 200                 205             


Ser Pro Ala Ser Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser 
    210                 215                 220                 


Ser Val Ser Ser Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro 
225                 230                 235                 240 


Ala Ser Pro Ala Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro 
                245                 250                 255     


Asp Lys His Arg Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile 
            260                 265                 270         


<210>  3
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  4
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Ser Lys Thr Leu Val Asp Met Asp Met Ala Asp Tyr Ser 
1               5                   10                  15      


Ala Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Val Gln 
            20                  25                  30          


Val Leu Thr Met Gly Asn Asp Thr Ser Pro Ser Glu Gly Thr Asn Leu 
        35                  40                  45              


Asn Ala Pro Asn Ser Leu Gly Val Ser Ala Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Ala Leu Leu Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Arg Gln Ile Thr Ser Pro Val Ser Gly Ile Asn Gly Asp Ile 
                165                 170                 175     


Arg Ala Lys Lys Ile Ala Ser Ile Ala Asp Val Cys Glu Ser Met Lys 
            180                 185                 190         


Glu Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Pro Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Val Phe Lys 
225                 230                 235                 240 


Asp Val Leu Leu Leu Gly Asn Asp Tyr Ile Val Pro Arg His Cys Pro 
                245                 250                 255     


Glu Leu Ala Glu Met Ser Arg Val Ser Ile Arg Ile Leu Asp Glu Leu 
            260                 265                 270         


Val Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Tyr 
        275                 280                 285             


Leu Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp 
    290                 295                 300                 


Pro Gly Lys Ile Lys Arg Leu Arg Ser Gln Val Gln Val Ser Leu Glu 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu 
                325                 330                 335     


Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile 
            340                 345                 350         


Glu Gln Ile Gln Phe Ile Lys Leu Phe Gly Met Ala Lys Ile Asp Asn 
        355                 360                 365             


Leu Leu Gln Glu Met Leu Leu Gly Gly Ser Pro Ser Asp Ala Pro His 
    370                 375                 380                 


Ala His His Pro Leu His Pro His Leu Met Gln Glu His Met Gly Thr 
385                 390                 395                 400 


Asn Val Ile Val Ala Asn Thr Met Pro Thr His Leu Ser Asn Gly Gln 
                405                 410                 415     


Met Ser Thr Pro Glu Thr Pro Gln Pro Ser Pro Pro Gly Gly Ser Gly 
            420                 425                 430         


Ser Glu Pro Tyr Lys Leu Leu Pro Gly Ala Val Ala Thr Ile Val Lys 
        435                 440                 445             


Pro Leu Ser Ala Ile Pro Gln Pro Thr Ile Thr Lys Gln Glu Val Ile 
    450                 455                 460                 


<210>  5
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser 
            260                 265                 270         


Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly 
        275                 280                 285             


Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 


His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     


Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         


Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             


His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 


Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 


Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser 
                405                 410                 415     


Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly 
            420                 425                 430         


Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val 
        435                 440                 445             


Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455         


<210>  6
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Val Asp Met 
        195                 200                 205             


Phe Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met 
    210                 215                 220                 


Ser Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn 
225                 230                 235                 240 


Ala Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile 
                245                 250                 255     


Lys Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys 
            260                 265                 270         


Ala Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu 
        275                 280                 285             


Gly Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly 
    290                 295                 300                 


Val Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys 
305                 310                 315                 320 


Arg Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser 
                325                 330                 335     


Gly Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser 
            340                 345                 350         


Asn Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu 
        355                 360                 365             


Pro Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr 
    370                 375                 380                 


Phe Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val 
385                 390                 395                 400 


Leu Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser 
                405                 410                 415     


Gln Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val 
            420                 425                 430         


Leu Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440             


