                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Posey, Avery
       June, Carl
 
<120>  Tn-MUC1 Chimeric Antigen Receptor (CAR) T Cell Therapy

<130>  046483-7229WO1(02184)

<150>  U.S. Provisional Application No. 62/824,532
<151>  2019-03-27

<150>  U.S. Provisional Application No. 62/881,269
<151>  2019-07-31

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5BBz)

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1476


<210>  2
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5BBz)

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  3
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  5e5

<400>  3
caggtgcagc tgcagcagtc tgatgccgag ctcgtgaagc ctggcagcag cgtgaagatc       60

agctgcaagg ccagcggcta caccttcacc gaccacgcca tccactgggt caagcagaag      120

cctgagcagg gcctggagtg gatcggccac ttcagccccg gcaacaccga catcaagtac      180

aacgacaagt tcaagggcaa ggccaccctg accgtggaca gaagcagcag caccgcctac      240

atgcagctga acagcctgac cagcgaggac agcgccgtgt acttctgcaa gaccagcacc      300

ttctttttcg actactgggg ccagggcaca accctgacag tgtctagcgg aggcggagga      360

tctggcggcg gaggaagtgg cggaggggga tctgaactcg tgatgaccca gagccccagc      420

tctctgacag tgacagccgg cgagaaagtg accatgatct gcaagtcctc ccagagcctg      480

ctgaactccg gcgaccagaa gaactacctg acctggtatc agcagaaacc cggccagccc      540

cccaagctgc tgatcttttg ggccagcacc cgggaaagcg gcgtgcccga tagattcaca      600

ggcagcggct ccggcaccga ctttaccctg accatcagct ccgtgcaggc cgaggacctg      660

gccgtgtatt actgccagaa cgactacagc taccccctga ccttcggagc cggcaccaag      720

ctggaactga ag                                                          732


<210>  4
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  5e5

<400>  4

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
    130                 135                 140                 


Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu 
145                 150                 155                 160 


Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys 
                


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<220>
<223>  5e5

<400>  5

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<220>
<223>  5e5

<400>  6

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  7
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM

<220>
<223>  CD8alpha

<400>  7

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  8
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TM

<220>
<223>  CD8alpha

<400>  8
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  4-1BB

<400>  9

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  10
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  4-1BB

<400>  10
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD3zeta

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD3zeta

<400>  12
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  13
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  CD8

<400>  13

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  14
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  CD8

<400>  14
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM

<220>
<223>  CD28

<400>  15

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  16
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TM

<220>
<223>  CD28

<400>  16
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  17
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD28

<400>  17

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  18
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD28

<400>  18
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC

<220>
<223>  CDR1

<400>  19

Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr 
1               5                   10                  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC

<220>
<223>  CDR2

<400>  20

Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser 
1               5                   10      


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC

<220>
<223>  CDR3

<400>  21

Gln Asn Asp Tyr Ser Tyr Pro Leu 
1               5               


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC

<220>
<223>  CDR1

<400>  22

Tyr Thr Phe Thr Asp His Ala Ile His 
1               5                   


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC

<220>
<223>  CDR2

<400>  23

Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr 
1               5                   10                  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC

<220>
<223>  CDR3

<400>  24

Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
1               5                   


<210>  25
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  ICOS

<400>  25

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  26
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  ICOS

<400>  26
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atctagactc acagatgtga cccta                      105


<210>  27
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  ICOS

<400>  27
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga cccta                      105


<210>  28
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD2

<400>  28

Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu 
1               5                   10                  15      


Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His 
            20                  25                  30          


Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro 
        35                  40                  45              


Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro 
    50                  55                  60                  


Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala 
65                  70                  75                  80  


Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg 
                85                  90                  95      


Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu 
            100                 105                 110         


Ser Pro Ser Ser Asn 
        115         


<210>  29
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD2

<400>  29
accaaaagga aaaaacagag gagtcggaga aatgatgagg agctggagac aagagcccac       60

agagtagcta ctgaagaaag gggccggaag ccccaccaaa ttccagcttc aacccctcag      120

aatccagcaa cttcccaaca tcctcctcca ccacctggtc atcgttccca ggcacctagt      180

catcgtcccc cgcctcctgg acaccgtgtt cagcaccagc ctcagaagag gcctcctgct      240

ccgtcgggca cacaagttca ccagcagaaa ggcccgcccc tccccagacc tcgagttcag      300

ccaaaacctc cccatggggc agcagaaaac tcattgtccc cttcctctaa t               351


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD3zeta (Q14K)

<400>  30

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  31
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD3zeta (Q14K)

<400>  31
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  32
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD28 (YMFM)

<400>  32

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Phe Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  33
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD28 (YMFM)

<400>  33
aggagtaaga ggagcaggct cctgcacagt gactacatgt tcatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  34
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD27

<400>  34

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  35
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  CD27

<400>  35
caacgaagga aatatagatc aaacaaagga gaaagtcctg tggagcctgc agagccttgt       60

cgttacagct gccccaggga ggaggagggc agcaccatcc ccatccagga ggattaccga      120

aaaccggagc ctgcctgctc cccc                                             144


<210>  36
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  OX40

<400>  36

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  37
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Domain

<220>
<223>  OX40

<400>  37
gccctgtacc tgctccgcag ggaccagagg ctgccccccg atgcccacaa gccccctggg       60

ggaggcagtt tcaggacccc catccaagag gagcaggccg acgcccactc caccctggcc      120

aagatc                                                                 126


<210>  38
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e528z)

<400>  38
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atttttgggt gctggtggtg      960

gttggtggag tcctggcttg ctatagcttg ctagtaacag tggcctttat tattttctgg     1020

gtgaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc     1080

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     1140

cgctccagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1200

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1260

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1482


<210>  39
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e528z)

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  40
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e528z YMFM)

<400>  40
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atttttgggt gctggtggtg      960

gttggtggag tcctggcttg ctatagcttg ctagtaacag tggcctttat tattttctgg     1020

gtgaggagta agaggagcag gctcctgcac agtgactaca tgttcatgac tccccgccgc     1080

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     1140

cgctccagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1200

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1260

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1482


<210>  41
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e528z YMFM)

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Phe Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  42
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e527z)

<400>  42
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgccaacga     1020

aggaaatata gatcaaacaa aggagaaagt cctgtggagc ctgcagagcc ttgtcgttac     1080

agctgcccca gggaggagga gggcagcacc atccccatcc aggaggatta ccgaaaaccg     1140

gagcctgcct gctcccccag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1200

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1260

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1320

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1380

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1440

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1494


<210>  43
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e527z)

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val 
            340                 345                 350         


Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly 
        355                 360                 365             


Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys 
    370                 375                 380                 


Ser Pro Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  44
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5Ox40z)

<400>  44
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcgccctg     1020

tacctgctcc gcagggacca gaggctgccc cccgatgccc acaagccccc tgggggaggc     1080

agtttcagga cccccatcca agaggagcag gccgacgccc actccaccct ggccaagatc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1476


<210>  45
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5Ox40z)

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
            340                 345                 350         


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
        355                 360                 365             


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  46
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5 CD2z)

<400>  46
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaccaaa     1020

aggaaaaaac agaggagtcg gagaaatgat gaggagctgg agacaagagc ccacagagta     1080

gctactgaag aaaggggccg gaagccccac caaattccag cttcaacccc tcagaatcca     1140

gcaacttccc aacatcctcc tccaccacct ggtcatcgtt cccaggcacc tagtcatcgt     1200

cccccgcctc ctggacaccg tgttcagcac cagcctcaga agaggcctcc tgctccgtcg     1260

ggcacacaag ttcaccagca gaaaggcccg cccctcccca gacctcgagt tcagccaaaa     1320

cctccccatg gggcagcaga aaactcattg tccccttcct ctaatatcga tagagtgaag     1380

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1440

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1500

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1560

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1620

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1680

cttcacatgc aggccctgcc ccctcgc                                         1707


<210>  47
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5 CD2z)

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu 
            340                 345                 350         


Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys 
        355                 360                 365             


Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln 
    370                 375                 380                 


His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg 
385                 390                 395                 400 


Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro 
                405                 410                 415     


Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu 
            420                 425                 430         


Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn 
        435                 440                 445             


Ser Leu Ser Pro Ser Ser Asn Ile Asp Arg Val Lys Phe Ser Arg Ser 
    450                 455                 460                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
465                 470                 475                 480 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                485                 490                 495     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            500                 505                 510         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        515                 520                 525             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    530                 535                 540                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
545                 550                 555                 560 


Leu His Met Gln Ala Leu Pro Pro Arg 
                565                 


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<220>
<223>  CD8alpha

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  49
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5ICOSz)

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp 
65                  70                  75                  80  


Ile Lys Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile 
                165                 170                 175     


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr 
            180                 185                 190         


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly 
305                 310                 315                 320 


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
                325                 330                 335     


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
            340                 345                 350         


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
        355                 360                 365             


Thr Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  50
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5ICOSz)

<400>  50
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtatca gcagaaaccc      600

ggccagcccc ccaagctgct gatcttttgg gccagcaccc gggaaagcgg cgtgcccgat      660

agattcacag gcagcggctc cggcaccgac tttaccctga ccatcagctc cgtgcaggcc      720

gaggacctgg ccgtgtatta ctgccagaac gactacagct accccctgac cttcggagcc      780

ggcaccaagc tggaactgaa gtccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atttctggtt acccatagga      960

tgtgcagcct ttgttgtagt ctgcattttg ggatgcatac ttatttgttg gcttacaaaa     1020

aagaagtatt catccagtgt gcacgaccct aacggtgaat acatgttcat gagagcagtg     1080

aacacagcca aaaaatccag actcacagat gtgaccctaa gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgc                                                      1455


<210>  51
<211>  1456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  Tn-MUC1 (5e5ICOSz-2)

<400>  51
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcagct gcagcagtct gatgccgagc tcgtgaagcc tggcagcagc      120

gtgaagatca gctgcaaggc cagcggctac accttcaccg accacgccat ccactgggtc      180

aagcagaagc ctgagcaggg cctggagtgg atcggccact tcagccccgg caacaccgac      240

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag aagcagcagc      300

accgcctaca tgcagctgaa cagcctgacc agcgaggaca gcgccgtgta cttctgcaag      360

accagcacct tctttttcga ctactggggc cagggcacaa ccctgacagt gtctagcgga      420

ggcggaggat ctggcggcgg aggaagtggc ggagggggat ctgaactcgt gatgacccag      480

agccccagct ctctgacagt gacagccggc gagaaagtga ccatgatctg caagtcctcc      540

cagagcctgc tgaactccgg cgaccagaag aactacctga cctggtattc agcagaaacc      600

cggccagccc cccaagctgc tgatcttttg ggccagcacc cgggaaagcg gcgtgcccga      660

tagattcaca ggcagcggct ccggcaccga ctttaccctg accatcagct ccgtgcaggc      720

cgaggacctg gccgtgtatt actgccagaa cgactacagc taccccctga ccttcggagc      780

cggcaccaag ctggaactga agtccggaac cacgacgcca gcgccgcgac caccaacacc      840

ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc      900

ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatttctggt tacccatagg      960

atgtgcagcc tttgttgtag tctgcatttt gggatgcata cttatttgtt ggcttacaaa     1020

aaagaagtat tcatccagtg tgcacgaccc taacggtgaa tacatgttca tgagagcagt     1080

gaacacagcc aaaaaatcta gactcacaga tgtgacccta agagtgaagt tcagcaggag     1140

cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg     1200

acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg     1260

aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat     1320

ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga     1380

tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca     1440

ggccctgccc cctcgc                                                     1456


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  1

<400>  52

Gly Ser Gly Gly Ser 
1               5   


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  2

<400>  53

Gly Gly Gly Ser 
1               


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  3

<400>  54

Gly Gly Gly Gly Ser 
1               5   


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  4

<400>  55

Gly Gly Ser Gly 
1               


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  5

<400>  56

Gly Gly Ser Gly Gly 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  6

<400>  57

Gly Ser Gly Ser Gly 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  7

<400>  58

Gly Ser Gly Gly Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  8

<400>  59

Gly Gly Gly Ser Gly 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  9

<400>  60

Gly Ser Ser Ser Gly 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  10

<400>  61

Gly Gly Gly Gly Ser 
1               5   


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  11

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  11

<400>  63
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  1

<400>  64

Asp Lys Thr His Thr 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  2

<400>  65

Cys Pro Pro Cys 
1               


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  3

<400>  66

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  4

<400>  67

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  5

<400>  68

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  6

<400>  69

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  7

<400>  70

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  Hu IgG1

<400>  71

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  Hu IgG2

<400>  72

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  Hu IgG3

<400>  73

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  Hu IgG4

<400>  74

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  Hu IgG1 H229Y

<400>  75

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  76
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  TGFbRII-DN

<400>  76

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Ser Gly 
        195                 200     


<210>  77
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  TGFbRII-DN

<400>  77
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

gga                                                                    603


<210>  78
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1-CTM-CD28

<400>  78

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        195                 200                 205             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    210                 215                 220                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235             


<210>  79
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1-CTM-CD28

<400>  79
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctcc            714


<210>  80
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1-PTM-CD28

<400>  80

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Arg 
            180                 185                 190         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230         


<210>  81
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1-PTM-CD28

<400>  81
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctcc                                696


<210>  82
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1A132L-PTM-CD28

<400>  82

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Arg 
            180                 185                 190         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230         


<210>  83
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1A132L-PTM-CD28

<400>  83
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgc                                   693


<210>  84
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1-4-1BB

<400>  84

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235         


<210>  85
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1-4-1BB

<400>  85
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact g               711


<210>  86
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1A132L-4-1BB

<400>  86

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235         


<210>  87
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  PD1A132L-4-1BB

<400>  87
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact g               711


<210>  88
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  TGFbR-IL12Rb1

<400>  88

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro 
145                 150                 155                 160 


Cys Ala Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln 
                165                 170                 175     


Trp Ile Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala 
            180                 185                 190         


Leu Val Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu 
        195                 200                 205             


Glu Lys Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr 
    210                 215                 220                 


Glu Leu Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
225                 230                 235             


<210>  89
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  TGFbR-IL12Rb1

<400>  89
atggaggcgg cggtcgctgc tccgcgtccc cggctgctcc tcctcgtgct ggcggcggcg       60

gcggcggcgg cggcggcgct gctcccgggg gcgacggcgt tacagtgttt ctgccacctc      120

tgtacaaaag acaattttac ttgtgtgaca gatgggctct gctttgtctc tgtcacagag      180

accacagaca aagttataca caacagcatg tgtatagctg aaattgactt aattcctcga      240

gataggccgt ttgtatgtgc accctcttca aaaactgggt ctgtgactac aacatattgc      300

tgcaatcagg accattgcaa taaaatagaa cttccaacta ctgtaaagtc atcacctggc      360

cttggtcctg tggaactggc agctgtcatt gctggaccag tgtgcttcgt ctgcatctca      420

ctcatgttga tggtctatat cagggccgca cggcacctgt gcccgccgct gcccacaccc      480

tgtgccagct ccgccattga gttccctgga gggaaggaga cttggcagtg gatcaaccca      540

gtggacttcc aggaagaggc atccctgcag gaggccctgg tggtagagat gtcctgggac      600

aaaggcgaga ggactgagcc tctcgagaag acagagctac ctgagggtgc ccctgagctg      660

gccctggata cagagttgtc cttggaggat ggagacaggt gcaaggccaa gatg            714


<210>  90
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  TGFbR-IL12Rb2

<400>  90

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Gln Gln Lys Val Phe 
            180                 185                 190         


Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro 
        195                 200                 205             


Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu 
    210                 215                 220                 


Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro 
225                 230                 235                 240 


Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val Leu His Gln Val Thr 
                245                 250                 255     


Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys 
            260                 265                 270         


Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met Met His Ser Ala 
        275                 280                 285             


Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu 
    290                 295                 300                 


Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro 
305                 310                 315                 320 


Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro 
                325                 330                 335     


Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His 
            340                 345                 350         


Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile 
        355                 360                 365             


Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser 
    370                 375                 380                 


Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser 
385                 390                 395                 400 


Leu Met Leu 
            


<210>  91
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  TGFbR-IL12Rb2

<400>  91
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ccagcaaaag gtgtttgttc tcctagcagc cctcagacct      600

cagtggtgta gcagagaaat tccagatcca gcaaatagca cttgcgctaa gaaatatccc      660

attgcagagg agaagacaca gctgcccttg gacaggctcc tgatagactg gcccacgcct      720

gaagatcctg aaccgctggt catcagtgaa gtccttcatc aagtgacccc agttttcaga      780

catcccccct gctccaactg gccacaaagg gaaaaaggaa tccaaggtca tcaggcctct      840

gagaaagaca tgatgcacag tgcctcaagc ccaccacctc caagagctct ccaagctgag      900

agcagacaac tggtggatct gtacaaggtg ctggagagca ggggctccga cccaaagcca      960

gaaaacccag cctgtccctg gacggtgctc ccagcaggtg accttcccac ccatgatggc     1020

tacttaccct ccaacataga tgacctcccc tcacatgagg cacctctcgc tgactctctg     1080

gaagaactgg agcctcagca catctccctt tctgttttcc cctcaagttc tcttcaccca     1140

ctcaccttct cctgtggtga taagctgact ctggatcagt taaagatgag gtgtgactcc     1200

ctcatgctc                                                             1209


<210>  92
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  Tim3-CD28

<400>  92

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Phe Trp Val Leu Val Val Val Gly 
        195                 200                 205             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    210                 215                 220                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
225                 230                 235                 240 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                245                 250                 255     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            260                 265             


<210>  93
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Receptor

<220>
<223>  Tim3-CD28

<400>  93
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctcc                                             804


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  T2A

<400>  94

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  95
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  T2A

<400>  95
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer

<220>
<223>  T2A

<400>  96

Ser Gly Arg Ser Gly Gly Gly 
1               5           


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer

<220>
<223>  T2A

<400>  97
tccggaagat ctggcggcgg a                                                 21


<210>  98
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  F2A

<400>  98

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  99
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  F2A

<400>  99
gtgaaacaga ctttgaattt tgaccttctc aagttggcgg gagacgtgga gtccaaccca       60

gggccg                                                                  66


<210>  100
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage

<220>
<223>  1


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  100

Arg Xaa Lys Arg 
1               


<210>  101
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage

<220>
<223>  2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  101

Arg Xaa Arg Arg 
1               


<210>  102
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage

<220>
<223>  3


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Arg Xaa Xaa Arg 
1               


<210>  103
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage

<220>
<223>  4

<400>  103

Arg Gly Lys Arg 
1               


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage

<220>
<223>  5


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is K or R

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is K or R

<400>  104

Xaa Arg Xaa Xaa Arg 
1               5   


<210>  105
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  F-GS2-T2A

<400>  105
cgtgcgaaga ggggcggcgg gggctccggc gggggaggca gtgagggccg cggctccctg       60

ctgacctgcg gagatgtaga agagaaccca ggcccc                                 96


<210>  106
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<220>
<223>  F-GS2-T2A

<400>  106

Arg Ala Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25                  30          


