                         SEQUENCE LISTING

<110>  Zymergen Inc.
 
<120>  ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF L-HOMOCYSTEINE
        BY FERMENTATION

<130>  ZMGNP023WO

<140>  PCT/US 20/______
<141>  2020-03-24

<150>  62/824,220
<151>  2019-03-26

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  433
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  1

Met Thr Val Pro Thr Leu Asn Lys Ala Ser Glu Lys Ile Ala Ser Arg 
1               5                   10                  15      


Glu Thr Leu Arg Leu Cys Thr Ala Gly Ser Val Asp Asp Gly Lys Ser 
            20                  25                  30          


Thr Phe Val Gly Arg Leu Leu His Asp Thr Lys Ser Val Leu Ala Asp 
        35                  40                  45              


Gln Leu Ala Ser Val Glu Arg Thr Ser Ala Asp Arg Gly Phe Glu Gly 
    50                  55                  60                  


Leu Asp Leu Ser Leu Leu Val Asp Gly Leu Arg Ala Glu Arg Glu Gln 
65                  70                  75                  80  


Gly Ile Thr Ile Asp Val Ala Tyr Arg Tyr Phe Ala Thr Asp Lys Arg 
                85                  90                  95      


Thr Phe Ile Leu Ala Asp Thr Pro Gly His Val Gln Tyr Thr Arg Asn 
            100                 105                 110         


Thr Val Thr Gly Val Ser Thr Ser Gln Val Val Val Leu Leu Val Asp 
        115                 120                 125             


Ala Arg His Gly Val Val Glu Gln Thr Arg Arg His Leu Ser Val Ser 
    130                 135                 140                 


Ala Leu Leu Gly Val Arg Thr Val Ile Leu Ala Val Asn Lys Ile Asp 
145                 150                 155                 160 


Leu Val Asp Tyr Ser Glu Glu Val Phe Arg Asn Ile Glu Lys Glu Phe 
                165                 170                 175     


Val Ser Leu Ala Ser Ala Leu Asp Val Thr Asp Thr His Val Val Pro 
            180                 185                 190         


Ile Ser Ala Leu Lys Gly Asp Asn Val Ala Glu Pro Ser Thr His Met 
        195                 200                 205             


Asp Trp Tyr Ala Gly Pro Thr Val Leu Glu Ile Leu Glu Asn Val Glu 
    210                 215                 220                 


Val Ser Arg Gly Arg Ala His Asp Leu Gly Phe Arg Phe Pro Ile Gln 
225                 230                 235                 240 


Tyr Val Ile Arg Glu His Ala Thr Asp Tyr Arg Gly Tyr Ala Gly Thr 
                245                 250                 255     


Ile Asn Ala Gly Ser Ile Ser Val Gly Asp Thr Val His Leu Pro Glu 
            260                 265                 270         


Gly Arg Thr Thr Gln Val Thr His Ile Asp Ser Ala Asp Gly Ser Leu 
        275                 280                 285             


Gln Thr Ala Ser Val Gly Glu Ala Val Val Leu Arg Leu Ala Gln Glu 
    290                 295                 300                 


Ile Asp Leu Ile Arg Gly Glu Leu Ile Ala Gly Ser Asp Arg Pro Glu 
305                 310                 315                 320 


Ser Val Arg Ser Phe Asn Ala Thr Val Val Gly Leu Ala Asp Arg Thr 
                325                 330                 335     


Ile Lys Pro Gly Ala Ala Val Lys Val Arg Tyr Gly Thr Glu Leu Val 
            340                 345                 350         


Arg Gly Arg Val Ala Ala Ile Glu Arg Val Leu Asp Ile Asp Gly Val 
        355                 360                 365             


Asn Asp Asn Glu Ala Pro Glu Thr Tyr Gly Leu Asn Asp Ile Ala His 
    370                 375                 380                 


Val Arg Ile Asp Val Ala Gly Glu Leu Glu Val Glu Asp Tyr Ala Ala 
385                 390                 395                 400 


Arg Gly Ala Ile Gly Ser Phe Leu Leu Ile Asp Gln Ser Ser Gly Asp 
                405                 410                 415     


Thr Leu Ala Ala Gly Leu Val Gly His Arg Leu Arg Asn Asn Trp Ser 
            420                 425                 430         


Ile 
    


<210>  2
<211>  261
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  2

Met Ser Phe Gln Leu Val Asn Ala Leu Lys Asn Thr Gly Ser Val Lys 
1               5                   10                  15      


Asp Pro Glu Ile Ser Pro Glu Gly Pro Arg Thr Thr Thr Pro Leu Ser 
            20                  25                  30          


Pro Glu Val Ala Lys His Asn Glu Glu Leu Val Glu Lys His Ala Ala 
        35                  40                  45              


Ala Leu Tyr Asp Ala Ser Ala Gln Glu Ile Leu Glu Trp Thr Ala Glu 
    50                  55                  60                  


His Thr Pro Gly Ala Ile Ala Val Thr Leu Ser Met Glu Asn Thr Val 
65                  70                  75                  80  


Leu Ala Glu Leu Ala Ala Arg His Leu Pro Glu Ala Asp Phe Leu Phe 
                85                  90                  95      


Leu Asp Thr Gly Tyr His Phe Lys Glu Thr Leu Glu Val Ala Arg Gln 
            100                 105                 110         


Val Asp Glu Arg Tyr Ser Gln Lys Leu Val Thr Ala Leu Pro Ile Leu 
        115                 120                 125             


Lys Arg Thr Glu Gln Asp Ser Ile Tyr Gly Leu Asn Leu Tyr Arg Ser 
    130                 135                 140                 


Asn Pro Ala Ala Cys Cys Arg Met Arg Lys Val Glu Pro Leu Ala Ala 
145                 150                 155                 160 


Ser Leu Ser Pro Tyr Ala Gly Trp Ile Thr Gly Leu Arg Arg Ala Asp 
                165                 170                 175     


Gly Pro Thr Arg Ala Gln Ala Pro Ala Leu Ser Leu Asp Ala Thr Gly 
            180                 185                 190         


Arg Leu Lys Ile Ser Pro Ile Ile Thr Trp Ser Leu Glu Glu Thr Asn 
        195                 200                 205             


Glu Phe Ile Ala Asp Asn Asn Leu Ile Asp His Pro Leu Thr His Gln 
    210                 215                 220                 


Gly Tyr Pro Ser Ile Gly Cys Glu Thr Cys Thr Leu Pro Val Ala Glu 
225                 230                 235                 240 


Gly Gln Asp Pro Arg Ala Gly Arg Trp Ala Gly Asn Ala Lys Thr Glu 
                245                 250                 255     


Cys Gly Leu His Ser 
            260     


<210>  3
<211>  561
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  3

Met Thr Thr Thr Thr Gly Ser Ala Arg Pro Ala Arg Ala Ala Arg Lys 
1               5                   10                  15      


Pro Lys Pro Glu Gly Gln Trp Lys Ile Asp Gly Thr Glu Pro Leu Asn 
            20                  25                  30          


His Ala Glu Glu Ile Lys Gln Glu Glu Pro Ala Phe Ala Val Lys Gln 
        35                  40                  45              


Arg Val Ile Asp Ile Tyr Ser Lys Gln Gly Phe Ser Ser Ile Ala Pro 
    50                  55                  60                  


Asp Asp Ile Ala Pro Arg Phe Lys Trp Leu Gly Ile Tyr Thr Gln Arg 
65                  70                  75                  80  


Lys Gln Asp Leu Gly Gly Glu Leu Thr Gly Gln Leu Pro Asp Asp Glu 
                85                  90                  95      


Leu Gln Asp Glu Tyr Phe Met Met Arg Val Arg Phe Asp Gly Gly Leu 
            100                 105                 110         


Ala Ser Pro Glu Arg Leu Arg Ala Val Gly Glu Ile Ser Arg Asp Tyr 
        115                 120                 125             


Ala Arg Ser Thr Ala Asp Phe Thr Asp Arg Gln Asn Ile Gln Leu His 
    130                 135                 140                 


Trp Ile Arg Ile Glu Asp Val Pro Ala Ile Trp Glu Lys Leu Glu Thr 
145                 150                 155                 160 


Val Gly Leu Ser Thr Met Leu Gly Cys Gly Asp Val Pro Arg Val Ile 
                165                 170                 175     


Leu Gly Ser Pro Val Ser Gly Val Ala Ala Glu Glu Leu Ile Asp Ala 
            180                 185                 190         


Thr Pro Ala Ile Asp Ala Ile Arg Glu Arg Tyr Leu Asp Lys Glu Glu 
        195                 200                 205             


Phe His Asn Leu Pro Arg Lys Phe Lys Thr Ala Ile Thr Gly Asn Gln 
    210                 215                 220                 


Arg Gln Asp Val Thr His Glu Ile Gln Asp Val Ser Phe Val Pro Ser 
225                 230                 235                 240 


Ile His Pro Glu Phe Gly Pro Gly Phe Glu Cys Phe Val Gly Gly Gly 
                245                 250                 255     


Leu Ser Thr Asn Pro Met Leu Ala Gln Pro Leu Gly Ser Trp Ile Pro 
            260                 265                 270         


Leu Asp Glu Val Pro Glu Val Trp Ala Gly Val Ala Gly Ile Phe Arg 
        275                 280                 285             


Asp Tyr Gly Phe Arg Arg Leu Arg Asn Arg Ala Arg Leu Lys Phe Leu 
    290                 295                 300                 


Val Ala Gln Trp Gly Ile Glu Lys Phe Arg Glu Val Leu Glu Thr Glu 
305                 310                 315                 320 


Tyr Leu Glu Arg Lys Leu Ile Asp Gly Pro Val Val Thr Thr Asn Pro 
                325                 330                 335     


Gly Tyr Arg Asp His Ile Gly Ile His Pro Gln Lys Asp Gly Lys Phe 
            340                 345                 350         


Tyr Leu Gly Val Lys Pro Thr Val Gly His Thr Thr Gly Glu Gln Leu 
        355                 360                 365             


Ile Ala Ile Ala Asp Val Ala Glu Lys His Gly Ile Thr Arg Ile Arg 
    370                 375                 380                 


Thr Thr Ala Glu Lys Glu Leu Leu Phe Leu Asp Ile Glu Arg Glu Asn 
385                 390                 395                 400 


Leu Thr Thr Val Ala Arg Asp Leu Asp Glu Ile Gly Leu Tyr Ser Ser 
                405                 410                 415     


Pro Ser Glu Phe Arg Arg Gly Ile Ile Ser Cys Thr Gly Leu Glu Phe 
            420                 425                 430         


Cys Lys Leu Ala His Ala Thr Thr Lys Ser Arg Ala Ile Glu Leu Val 
        435                 440                 445             


Asp Glu Leu Glu Glu Arg Leu Gly Asp Leu Asp Val Pro Ile Lys Ile 
    450                 455                 460                 


Ala Leu Asn Gly Cys Pro Asn Ser Cys Ala Arg Thr Gln Val Ser Asp 
465                 470                 475                 480 


Ile Gly Phe Lys Gly Gln Thr Val Thr Asp Ala Asp Gly Asn Arg Val 
                485                 490                 495     


Glu Gly Phe Gln Val His Leu Gly Gly Ser Met Asn Leu Asp Pro Asn 
            500                 505                 510         


Phe Gly Arg Lys Leu Lys Gly His Lys Val Ile Ala Asp Glu Val Gly 
        515                 520                 525             


Glu Tyr Val Thr Arg Val Val Thr His Phe Lys Glu Gln Arg His Glu 
    530                 535                 540                 


Asp Glu His Phe Arg Asp Trp Val Gln Arg Ala Ala Glu Glu Asp Leu 
545                 550                 555                 560 


Val 
    


<210>  4
<211>  262
<212>  PRT
<213>  Lactobacillus acidophilus

<400>  4

Met Ala Asn Lys Val Lys Ile Gly Ile Leu Asn Leu Met His Asp Lys 
1               5                   10                  15      


Leu Asp Thr Gln Ser His Phe Ile Lys Val Leu Pro Asn Ala Asp Leu 
            20                  25                  30          


Thr Phe Phe Tyr Pro Arg Met His Tyr Gln Asn Arg Pro Ile Pro Pro 
        35                  40                  45              


Glu Val Asn Met Thr Ser Glu Pro Leu Asp Ile Asn Arg Val Ser Glu 
    50                  55                  60                  


Phe Asp Gly Phe Ile Ile Thr Gly Ala Pro Ile Asp Gln Ile Asp Phe 
65                  70                  75                  80  


Ser Lys Ile Thr Tyr Ile Glu Glu Ile Arg Tyr Leu Leu Gln Ala Leu 
                85                  90                  95      


Asp Asn His Lys Ile Gln Gln Leu Tyr Phe Cys Trp Gly Ala Met Ala 
            100                 105                 110         


Ala Leu Asn Tyr Phe Tyr Gly Ile Lys Lys Lys Ile Leu Ala Glu Lys 
        115                 120                 125             


Ile Phe Gly Val Phe Pro His Leu Ile Thr Glu Pro His Pro Leu Leu 
    130                 135                 140                 


Ser Gly Leu Ser Gln Gly Phe Met Ala Pro His Ala Arg Tyr Ala Glu 
145                 150                 155                 160 


Met Asp Lys Lys Gln Ile Met Gln Asp Glu Arg Leu Ala Ile Asn Ala 
                165                 170                 175     


Val Asp Asp Asn Ser His Leu Phe Met Val Ser Ala Lys Asp Asn Pro 
            180                 185                 190         


Glu Arg Asn Phe Ile Phe Ser His Ile Glu Tyr Gly Lys Asp Ser Leu 
        195                 200                 205             


Arg Asp Glu Tyr Asn Arg Glu Ile Asn Ala His Pro Glu Arg His Tyr 
    210                 215                 220                 


Lys Lys Pro Ile Asn Tyr Ser Met Ser Asn Pro Ser Phe Gln Trp Gln 
225                 230                 235                 240 


Asp Thr Gln Lys Ile Phe Phe Asn Asn Trp Leu Lys Lys Val Lys Asp 
                245                 250                 255     


Asn Lys Leu Val Leu Asn 
            260         


<210>  5
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated (feedback-deregulated) sequence

<400>  5

Met Thr Ser Ala Ser Ala Pro Ser Phe Asn Pro Gly Lys Gly Pro Gly 
1               5                   10                  15      


Ser Ala Val Gly Ile Ala Leu Leu Gly Phe Gly Thr Val Gly Thr Glu 
            20                  25                  30          


Val Met Arg Leu Met Thr Glu Tyr Gly Asp Glu Leu Ala His Arg Ile 
        35                  40                  45              


Gly Gly Pro Leu Glu Val Arg Gly Ile Ala Val Ser Asp Ile Ser Lys 
    50                  55                  60                  


Pro Arg Glu Gly Val Ala Pro Glu Leu Leu Thr Glu Asp Ala Phe Ala 
65                  70                  75                  80  


Leu Ile Glu Arg Glu Asp Val Asp Ile Val Val Glu Val Ile Gly Gly 
                85                  90                  95      


Ile Glu Tyr Pro Arg Glu Val Val Leu Ala Ala Leu Lys Ala Gly Lys 
            100                 105                 110         


Ser Val Val Thr Ala Asn Lys Ala Leu Val Ala Ala His Ser Ala Glu 
        115                 120                 125             


Leu Ala Asp Ala Ala Glu Ala Ala Asn Val Asp Leu Tyr Phe Glu Ala 
    130                 135                 140                 


Ala Val Ala Gly Ala Ile Pro Val Val Gly Pro Leu Arg Arg Ser Leu 
145                 150                 155                 160 


Ala Gly Asp Gln Ile Gln Ser Val Met Gly Ile Val Asn Gly Thr Thr 
                165                 170                 175     


Asn Phe Ile Leu Asp Ala Met Asp Ser Thr Gly Ala Asp Tyr Ala Asp 
            180                 185                 190         


Ser Leu Ala Glu Ala Thr Arg Leu Gly Tyr Ala Glu Ala Asp Pro Thr 
        195                 200                 205             


Ala Asp Val Glu Gly His Asp Ala Ala Ser Lys Ala Ala Ile Leu Ala 
    210                 215                 220                 


Ser Ile Ala Phe His Thr Arg Val Thr Ala Asp Asp Val Tyr Cys Glu 
225                 230                 235                 240 


Gly Ile Ser Asn Ile Ser Ala Ala Asp Ile Glu Ala Ala Gln Gln Ala 
                245                 250                 255     


Gly His Thr Ile Lys Leu Leu Ala Ile Cys Glu Lys Phe Thr Asn Lys 
            260                 265                 270         


Glu Gly Lys Ser Ala Ile Ser Ala Arg Val His Pro Thr Leu Leu Pro 
        275                 280                 285             


Val Ser His Pro Leu Ala Ser Val Asn Lys Ser Phe Asn Ala Ile Phe 
    290                 295                 300                 


Val Glu Ala Glu Ala Ala Gly Arg Leu Met Phe Tyr Gly Asn Gly Ala 
305                 310                 315                 320 


Gly Gly Ala Pro Thr Ala Ser Ala Val Leu Gly Asp Val Val Gly Ala 
                325                 330                 335     


Ala Arg Asn Lys Val His Gly Gly Arg Ala Pro Gly Glu Ser Thr Tyr 
            340                 345                 350         


Ala Asn Leu Pro Ile Ala Asp Phe Gly Glu Thr Thr Thr Arg Tyr His 
        355                 360                 365             


Leu Asp Met Asp Val Glu Asp Arg Val Glu Val Leu Ala Glu Leu Ala 
    370                 375                 380                 


Ser Leu Phe Ser Glu Gln Gly Ile Ser Leu Arg Thr Ile Arg Gln Glu 
385                 390                 395                 400 


Glu Arg Asp Asp Asp Ala Arg Leu Ile Val Val Thr His Ser Ala Leu 
                405                 410                 415     


Glu Ser Asp Leu Ser Arg Thr Val Glu Leu Leu Lys Ala Lys Pro Val 
            420                 425                 430         


Val Lys Ala Ile Asn Ser Val Ile Arg Leu Glu Arg Asp 
        435                 440                 445 


<210>  6
<211>  427
<212>  PRT
<213>  Lactobacillus collinoides

<400>  6

Met Thr Asp Thr Ser Lys Leu His Phe Glu Thr Lys Gln Val His Ala 
1               5                   10                  15      


Gly Gln Val Val Asp Glu Thr Gly Ala Arg Ala Val Pro Ile Tyr Gln 
            20                  25                  30          


Thr Thr Ser Tyr Val Phe Lys Asp Ala Ala Gln Ala Ala Gly Arg Phe 
        35                  40                  45              


Gly Leu Thr Asp Pro Gly Asn Ile Tyr Thr Arg Leu Thr Asn Pro Thr 
    50                  55                  60                  


Thr Asp Val Leu Glu Lys Arg Val Ala Gln Leu Glu Asn Gly Thr Ala 
65                  70                  75                  80  


Gly Val Ala Leu Ala Thr Gly Ala Ala Ala Val Thr Ala Ala Ile Glu 
                85                  90                  95      


Asn Val Ala Asn Ala Gly Asp Asn Ile Val Ser Ala Ser Thr Leu Tyr 
            100                 105                 110         


Gly Gly Thr Tyr Asp Leu Phe Ser Val Thr Leu Pro Lys Leu Gly Ile 
        115                 120                 125             


Thr Thr Thr Phe Val Asp Pro Asp Asp Pro Gln Asn Phe Ala Lys Ala 
    130                 135                 140                 


Ile Asp Asp Lys Thr Lys Ala Leu Tyr Ile Glu Thr Ile Gly Asn Pro 
145                 150                 155                 160 


Gly Ile Asn Ile Ile Asp Ile Glu Ala Val Ala Lys Ile Ala His Asp 
                165                 170                 175     


Asn Gly Ile Val Leu Ile Ala Asp Asn Thr Phe Gly Thr Pro Tyr Leu 
            180                 185                 190         


Ile Gln Pro Leu Asp His Gly Val Asp Val Val Ile His Ser Ala Thr 
        195                 200                 205             


Lys Phe Ile Gly Gly His Gly Thr Thr Met Gly Gly Val Ile Val Glu 
    210                 215                 220                 


Asn Gly Lys Phe Asp Tyr Ala Lys Ser Gly Lys Tyr Pro Asp Phe Thr 
225                 230                 235                 240 


Thr Pro Asp Asp Thr Tyr Asn Gly Ile Val Trp Asn Asp Ile Asn Pro 
                245                 250                 255     


Ala Thr Phe Thr Thr Lys Val Arg Ala Gln Thr Leu Arg Asp Thr Gly 
            260                 265                 270         


Ala Thr Ile Ser Pro Phe Asn Ser Phe Leu Leu Leu Gln Gly Leu Glu 
        275                 280                 285             


Ser Leu Ser Leu Arg Val Glu Arg His Val Ser Asn Ala Gln Lys Ile 
    290                 295                 300                 


Ala Lys Phe Leu Asn Asp His Pro Lys Val Ala Trp Val Asn Tyr Pro 
305                 310                 315                 320 


Gly Leu Pro Gly Asn Lys Tyr Asn Asp Leu Ala Lys Lys Tyr Phe Pro 
                325                 330                 335     


Lys Gly Thr Gly Ser Ile Phe Thr Ile Gly Leu Lys Gly Gly Glu Lys 
            340                 345                 350         


Ala Gly Lys Asp Leu Ile Glu Lys Leu Asn Leu Phe Ser Leu Leu Ala 
        355                 360                 365             


Asn Val Gly Asp Ala Lys Ser Leu Ile Ile His Pro Ala Ser Thr Thr 
    370                 375                 380                 


His Ala Gln Leu Asn Glu Glu Gln Leu Lys Glu Thr Gly Ile Thr Pro 
385                 390                 395                 400 


Asp Leu Ile Arg Leu Ser Ile Gly Ile Glu Asn Val Asp Asp Leu Ile 
                405                 410                 415     


Ala Asp Leu Ser Gln Ala Leu Asp Gln Ile Asp 
            420                 425         


<210>  7
<211>  304
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  7

Met Thr Thr Thr Val Ala Ser Glu Leu Ser Pro His Leu Lys Asp Leu 
1               5                   10                  15      


Glu Asn Glu Ser Ile His Ile Leu Arg Glu Val Ala Gly Gln Phe Asp 
            20                  25                  30          


Lys Val Gly Leu Leu Phe Ser Gly Gly Lys Asp Ser Val Val Val Tyr 
        35                  40                  45              


Glu Leu Ala Arg Arg Ala Phe Ala Pro Ala Asn Val Pro Phe Glu Leu 
    50                  55                  60                  


Leu His Val Asp Thr Gly His Asn Phe Pro Glu Val Leu Glu Phe Arg 
65                  70                  75                  80  


Asp Asn Leu Val Glu Arg Thr Gly Ala Arg Leu Arg Val Ala Lys Val 
                85                  90                  95      


Gln Asp Trp Ile Asp Arg Gly Asp Leu Gln Glu Arg Pro Asp Gly Thr 
            100                 105                 110         


Arg Asn Pro Leu Gln Thr Val Pro Leu Val Glu Thr Ile Ala Glu Gln 
        115                 120                 125             


Gly Tyr Asp Ala Val Leu Gly Gly Ala Arg Arg Asp Glu Glu Arg Ala 
    130                 135                 140                 


Arg Ala Lys Glu Arg Val Phe Ser Val Arg Asp Ser Phe Gly Gly Trp 
145                 150                 155                 160 


Asp Pro Arg Arg Gln Arg Pro Glu Leu Trp Thr Leu Tyr Asn Gly Gly 
                165                 170                 175     


His Leu Pro Gly Glu Asn Ile Arg Val Phe Pro Ile Ser Asn Trp Thr 
            180                 185                 190         


Glu Ala Asp Ile Trp Glu Tyr Ile Gly Ala Arg Gly Ile Glu Leu Pro 
        195                 200                 205             


Pro Ile Tyr Phe Ser His Asp Arg Glu Val Phe Glu Arg Asp Gly Met 
    210                 215                 220                 


Trp Leu Thr Ala Gly Glu Trp Gly Gly Pro Lys Lys Gly Glu Glu Ile 
225                 230                 235                 240 


Val Thr Lys Thr Val Arg Tyr Arg Thr Val Gly Asp Met Ser Cys Thr 
                245                 250                 255     


Gly Ala Val Leu Ser Glu Ala Arg Thr Ile Asp Asp Val Ile Glu Glu 
            260                 265                 270         


Ile Ala Thr Ser Thr Leu Thr Glu Arg Gly Ala Thr Arg Ala Asp Asp 
        275                 280                 285             


Arg Leu Ser Glu Ser Ala Met Glu Asp Arg Lys Lys Glu Gly Tyr Phe 
    290                 295                 300                 


<210>  8
<211>  912
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  8
atgaccacaa ccgttgcatc agaactttcc ccacacctta aagatcttga aaatgaatcc       60

atccacatcc tccgcgaggt agctggccag tttgataagg tcggcctgct gttttccggc      120

ggtaaggatt ccgtcgtggt gtacgagctt gcgcgccgcg ctttcgctcc agctaacgtg      180

ccttttgaat tgctgcacgt ggacaccggc cacaacttcc cagaggtttt ggaattccgc      240

gacaacctgg tggagcgcac cggcgcccgc ctgcgcgtag ctaaagtcca ggactggatc      300

gatcgcggtg acctgcagga acgcccagac ggcacccgca acccactgca gactgtccct      360

ttggtggaga ccatcgctga gcagggctac gacgccgtgc ttggtggcgc tcgccgcgat      420

gaggagcgtg cccgcgccaa ggagcgtgtg ttctctgtgc gtgactcctt cggtggttgg      480

gatccacgcc gtcagcgccc agagctgtgg accctctaca acggtggcca cctgccaggc      540

gaaaacatcc gtgttttccc aatctccaac tggactgaag ctgacatctg ggagtacatc      600

ggcgcccgtg gcatcgaact tccaccgatc tacttctccc acgaccgcga agttttcgag      660

cgcgacggca tgtggctgac cgcaggcgag tggggtggac caaagaaggg cgaggagatc      720

gtcaccaaga ctgttcgcta ccgcaccgtc ggcgatatgt cctgcaccgg tgctgtgctc      780

tcagaagccc gcaccattga cgatgtgatc gaagagatcg ccacctccac ccttaccgaa      840

cgtggcgcaa cccgcgccga tgaccgcctc agcgaatccg caatggaaga ccgcaagaag      900

gaaggctact tc                                                          912


<210>  9
<211>  783
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  9
atgagctttc aactagttaa cgccctgaaa aatactggtt cggtaaaaga tcccgagatc       60

tcacccgaag gacctcgcac gaccacaccg ttgtcaccag aggtagcaaa acacaacgag      120

gaactcgtcg aaaagcatgc tgctgcgttg tatgacgcca gcgcgcaaga gatcctggaa      180

tggacagccg agcacacgcc gggcgctatt gcagtgacct tgagcatgga aaacaccgta      240

ctggcggagc tggctgcgcg gcacctgccg gaagctgatt tcctcttttt ggacaccggt      300

taccacttca aggaaactct tgaagttgcc cgccaggtag atgagcgtta ttcccagaag      360

cttgtcaccg cgctgccaat cctcaagcgc acggagcagg attccattta tggtctcaac      420

ctgtaccgca gcaacccagc ggcgtgctgc cgaatgcgca aagttgaacc gctggcggcg      480

tcgttaagcc catacgctgg ctggatcacc ggcctgcgcc gcgctgatgg cccaacccgt      540

gctcaagccc ctgcgctgag cttggatgcc accggcaggc tcaagatttc tccaattatc      600

acctggtcat tggaggaaac caacgagttc attgcggaca acaacctcat cgatcaccca      660

cttacccatc agggttatcc atcaattgga tgcgaaacct gcacccttcc tgttgctgaa      720

ggacaagacc ctagggccgg ccgttgggct ggaaacgcca agacagaatg cggacttcac      780

tca                                                                    783


<210>  10
<211>  1683
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  10
atgacaacaa ccaccggaag tgcccggcca gcacgtgccg ccaggaagcc taagcccgaa       60

ggccaatgga aaatcgacgg caccgagccg cttaaccatg ccgaggaaat taagcaagaa      120

gaacccgctt ttgctgtcaa gcagcgggtc attgatattt actccaagca gggtttttct      180

tccattgcac cggatgacat tgccccacgc tttaagtggt tgggcattta cacccagcgt      240

aagcaggatc tgggcggtga actgaccggt cagcttcctg atgatgagct gcaggatgag      300

tacttcatga tgcgtgtgcg ttttgatggc ggactggctt cccctgagcg cctgcgtgcc      360

gtgggtgaaa tttctaggga ttatgctcgt tccaccgcgg acttcaccga ccgccagaac      420

attcagctgc actggattcg tattgaagat gtgcctgcga tctgggagaa gctagaaacc      480

gtcggactgt ccaccatgct tggttgcggt gacgttccac gtgttatctt gggctcccca      540

gtttctggcg tagctgctga agagctgatc gatgccaccc cggctatcga tgcgattcgt      600

gagcgctacc tagacaagga agagttccac aaccttcctc gtaagtttaa gactgctatc      660

actggcaacc agcgccagga tgttacccac gaaatccagg acgtttcctt cgttccttcg      720

attcacccag aattcggccc aggatttgag tgctttgtgg gcggcggcct gtccaccaac      780

ccaatgcttg ctcagccact tggttcttgg attccacttg atgaggttcc agaagtgtgg      840

gctggcgtcg ccggaatttt ccgcgactac ggcttccgac gcctgcgtaa ccgtgctcgc      900

ctcaagttct tggtggcaca gtggggtatt gagaagttcc gtgaagttct tgagaccgaa      960

tacctcgagc gcaagctgat tgatggccca gttgttacca ccaaccctgg ctaccgtgac     1020

cacattggca ttcacccaca aaaggacggc aagttctacc tcggtgtgaa gccaaccgtt     1080

ggacacacca ccggtgagca gctcattgcc attgctgatg ttgcagaaaa gcacggcatc     1140

accaggattc gtaccacggc ggaaaaggaa ctgctcttcc tcgatattga gcgagagaac     1200

cttactaccg ttgcacgtga cctggatgaa atcggactgt actcttcacc ttccgagttc     1260

cgccgcggca tcatttcctg caccggcttg gagttctgca agcttgcgca cgcaaccacc     1320

aagtcacgag caattgagct tgtggacgaa ctggaagagc gactcggcga tttggatgtt     1380

cccatcaaga ttgccctgaa cggttgccct aactcttgtg cacgcaccca ggtttccgac     1440

atcggattca agggacagac cgtcactgat gctgacggca accgcgttga aggtttccag     1500

gttcacctgg gcggttccat gaacttggat ccaaacttcg gacgcaagct caagggccac     1560

aaggttattg ccgatgaagt gggagagtac gtcactcgcg ttgttaccca cttcaaggaa     1620

cagcgccacg aggacgagca cttccgcgat tgggtccagc gggccgctga ggaagatttg     1680

gtg                                                                   1683


<210>  11
<211>  445
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  11

Met Thr Ser Ala Ser Ala Pro Ser Phe Asn Pro Gly Lys Gly Pro Gly 
1               5                   10                  15      


Ser Ala Val Gly Ile Ala Leu Leu Gly Phe Gly Thr Val Gly Thr Glu 
            20                  25                  30          


Val Met Arg Leu Met Thr Glu Tyr Gly Asp Glu Leu Ala His Arg Ile 
        35                  40                  45              


Gly Gly Pro Leu Glu Val Arg Gly Ile Ala Val Ser Asp Ile Ser Lys 
    50                  55                  60                  


Pro Arg Glu Gly Val Ala Pro Glu Leu Leu Thr Glu Asp Ala Phe Ala 
65                  70                  75                  80  


Leu Ile Glu Arg Glu Asp Val Asp Ile Val Val Glu Val Ile Gly Gly 
                85                  90                  95      


Ile Glu Tyr Pro Arg Glu Val Val Leu Ala Ala Leu Lys Ala Gly Lys 
            100                 105                 110         


Ser Val Val Thr Ala Asn Lys Ala Leu Val Ala Ala His Ser Ala Glu 
        115                 120                 125             


Leu Ala Asp Ala Ala Glu Ala Ala Asn Val Asp Leu Tyr Phe Glu Ala 
    130                 135                 140                 


Ala Val Ala Gly Ala Ile Pro Val Val Gly Pro Leu Arg Arg Ser Leu 
145                 150                 155                 160 


Ala Gly Asp Gln Ile Gln Ser Val Met Gly Ile Val Asn Gly Thr Thr 
                165                 170                 175     


Asn Phe Ile Leu Asp Ala Met Asp Ser Thr Gly Ala Asp Tyr Ala Asp 
            180                 185                 190         


Ser Leu Ala Glu Ala Thr Arg Leu Gly Tyr Ala Glu Ala Asp Pro Thr 
        195                 200                 205             


Ala Asp Val Glu Gly His Asp Ala Ala Ser Lys Ala Ala Ile Leu Ala 
    210                 215                 220                 


Ser Ile Ala Phe His Thr Arg Val Thr Ala Asp Asp Val Tyr Cys Glu 
225                 230                 235                 240 


Gly Ile Ser Asn Ile Ser Ala Ala Asp Ile Glu Ala Ala Gln Gln Ala 
                245                 250                 255     


Gly His Thr Ile Lys Leu Leu Ala Ile Cys Glu Lys Phe Thr Asn Lys 
            260                 265                 270         


Glu Gly Lys Ser Ala Ile Ser Ala Arg Val His Pro Thr Leu Leu Pro 
        275                 280                 285             


Val Ser His Pro Leu Ala Ser Val Asn Lys Ser Phe Asn Ala Ile Phe 
    290                 295                 300                 


Val Glu Ala Glu Ala Ala Gly Arg Leu Met Phe Tyr Gly Asn Gly Ala 
305                 310                 315                 320 


Gly Gly Ala Pro Thr Ala Ser Ala Val Leu Gly Asp Val Val Gly Ala 
                325                 330                 335     


Ala Arg Asn Lys Val His Gly Gly Arg Ala Pro Gly Glu Ser Thr Tyr 
            340                 345                 350         


Ala Asn Leu Pro Ile Ala Asp Phe Gly Glu Thr Thr Thr Arg Tyr His 
        355                 360                 365             


Leu Asp Met Asp Val Glu Asp Arg Val Glu Val Leu Ala Glu Leu Ala 
    370                 375                 380                 


Ser Leu Phe Ser Glu Gln Gly Ile Ser Leu Arg Thr Ile Arg Gln Glu 
385                 390                 395                 400 


Glu Arg Asp Asp Asp Ala Arg Leu Ile Val Val Thr His Ser Ala Leu 
                405                 410                 415     


Glu Ser Asp Leu Ser Arg Thr Val Glu Leu Leu Lys Ala Lys Pro Val 
            420                 425                 430         


Val Lys Ala Ile Asn Ser Val Ile Arg Leu Glu Arg Asp 
        435                 440                 445 


