                         SEQUENCE LISTING

<110>  UMC Utrecht Holding B.V.
 
<120>  ENGINEERED IGA ANTIBODIES AND METHODS OF USE

<130>  P126851PC00

<140>  PCT/NL2020/050217
<141>  2020-03-27

<150>  US 62/824,864
<151>  2019-03-27

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2m1

<400>  1

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  2
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2m2

<400>  2

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  3
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2_A0A286YEY5

<400>  3

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Ser Cys Cys Val Ala Asp Trp Gln Met Pro Pro Pro Tyr Val Val 
                325                 330                 335     


Leu Asp Leu Pro Gln Glu Thr Leu Glu Glu Glu Thr Pro Gly Ala Asn 
            340                 345                 350         


Leu Trp Pro Thr Thr Ile Thr Phe Leu Thr Leu Phe Leu Leu Ser Leu 
        355                 360                 365             


Phe Tyr Ser Thr Ala Leu Thr Val Thr Ser Val Arg Gly Pro Ser Gly 
    370                 375                 380                 


Lys Arg Glu Gly Pro Gln Tyr 
385                 390     


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dinutuximab (also called Ch14.18 or Unituxin)

<400>  4

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dinutuximab (also called Ch14.18 or Unituxin)

<400>  5

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 epitope

<400>  6

Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser Thr 
1               5                   10                  15      


Gln Tyr Cys Tyr Ser 
            20      


<210>  7
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UMAB10

<400>  7

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Phe Thr Phe Pro Ser Tyr 
            20                  25                  30          


Asn Leu His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Ser Asn Val Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UMAB10

<400>  8

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Asp Leu Lys 
            100                 105     


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tail piece

<400>  9

Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp Gly Thr 
1               5                   10                  15      


Cys Tyr 
        


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  10

Glu Phe Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  11

Ile Arg Asn Arg Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  12

Ala Arg Val Ser Asn Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  13

Gln Ser Leu Leu Lys Asn Asn Gly Asn Thr Phe Leu 
1               5                   10          


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  14

Lys Val Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  15

Ser Gln Ser Thr His Ile Pro Tyr Thr 
1               5                   


<210>  16
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA3.0+

<400>  16

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Gln Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr 
        


<210>  17
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA3.0min

<400>  17

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys 
        


<210>  18
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NG

<400>  18

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Gly Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys 
        


<210>  19
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NQ

<400>  19

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Gln Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys 
        


<210>  20
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NT

<400>  20

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Thr Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys 
        


<210>  21
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NLT-TIS

<400>  21

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Thr Ile Ser Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys 
        


<210>  22
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA2m1

<400>  22
gccagcccca ccagccccaa ggtgttcccc ctgagcctgg acagcacccc ccaggacggc       60

aacgtggtgg tggcctgcct ggtgcagggc ttcttccccc aggagcccct gagcgtgacc      120

tggagcgaga gcggccagaa cgtgaccgcc aggaacttcc cccccagcca ggacgccagc      180

ggcgacctgt acaccaccag cagccagctg accctgcccg ccacccagtg ccccgacggc      240

aagagcgtga cctgccacgt gaagcactac accaacccca gccaggacgt gaccgtgccc      300

tgccccgtgc cccccccccc cccctgctgc caccccaggc tgagcctgca caggcccgcc      360

ctggaggacc tgctgctggg cagcgaggcc aacctgacct gcaccctgac cggcctgagg      420

gacgccagcg gcgccacctt cacctggacc cccagcagcg gcaagagcgc cgtgcagggc      480

ccccccgaga gggacctgtg cggctgctac agcgtgagca gcgtgctgcc cggctgcgcc      540

cagccctgga accacggcga gaccttcacc tgcaccgccg cccaccccga gctgaagacc      600

cccctgaccg ccaacatcac caagagcggc aacaccttca ggcccgaggt gcacctgctg      660

ccccccccca gcgaggagct ggccctgaac gagctggtga ccctgacctg cctggccagg      720

ggcttcagcc ccaaggacgt gctggtgagg tggctgcagg gcagccagga gctgcccagg      780

gagaagtacc tgacctgggc cagcaggcag gagcccagcc agggcaccac caccttcgcc      840

gtgaccagca tcctgagggt ggccgccgag gactggaaga agggcgacac cttcagctgc      900

atggtgggcc acgaggccct gcccctggcc ttcacccaga agaccatcga caggctggcc      960

ggcaagccca cccacgtgaa cgtgagcgtg gtgatggccg aggtggacgg cacctgctac     1020


<210>  23
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA2m2

<400>  23
gccagcccca ccagccccaa ggtgttcccc ctgagcctgg acagcacccc ccaggacggc       60

aacgtggtgg tggcctgcct ggtgcagggc ttcttccccc aggagcccct gagcgtgacc      120

tggagcgaga gcggccagaa cgtgaccgcc aggaacttcc cccccagcca ggacgccagc      180

ggcgacctgt acaccaccag cagccagctg accctgcccg ccacccagtg ccccgacggc      240

aagagcgtga cctgccacgt gaagcactac accaacagca gccaggacgt gaccgtgccc      300

tgcagggtgc cccccccccc cccctgctgc caccccaggc tgagcctgca caggcccgcc      360

ctggaggacc tgctgctggg cagcgaggcc aacctgacct gcaccctgac cggcctgagg      420

gacgccagcg gcgccacctt cacctggacc cccagcagcg gcaagagcgc cgtgcagggc      480

ccccccgaga gggacctgtg cggctgctac agcgtgagca gcgtgctgcc cggctgcgcc      540

cagccctgga accacggcga gaccttcacc tgcaccgccg cccaccccga gctgaagacc      600

cccctgaccg ccaacatcac caagagcggc aacaccttca ggcccgaggt gcacctgctg      660

ccccccccca gcgaggagct ggccctgaac gagctggtga ccctgacctg cctggccagg      720

ggcttcagcc ccaaggacgt gctggtgagg tggctgcagg gcagccagga gctgcccagg      780

gagaagtacc tgacctgggc cagcaggcag gagcccagcc agggcaccac cacctacgcc      840

gtgaccagca tcctgagggt ggccgccgag gactggaaga agggcgagac cttcagctgc      900

atggtgggcc acgaggccct gcccctggcc ttcacccaga agaccatcga caggatggcc      960

ggcaagccca cccacatcaa cgtgagcgtg gtgatggccg aggccgacgg cacctgctac     1020


<210>  24
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA2_A0A286YEY5

<400>  24
gccagcccca ccagccccaa ggtgttcccc ctgagcctgg acagcacccc ccaggacggc       60

aacgtggtgg tggcctgcct ggtgcagggc ttcttccccc aggagcccct gagcgtgacc      120

tggagcgaga gcggccagaa cgtgaccgcc aggaacttcc cccccagcca ggacgccagc      180

ggcgacctgt acaccaccag cagccagctg accctgcccg ccacccagtg ccccgacggc      240

aagagcgtga cctgccacgt gaagcactac accaacagca gccaggacgt gaccgtgccc      300

tgcagggtgc cccccccccc cccctgctgc caccccaggc tgagcctgca caggcccgcc      360

ctggaggacc tgctgctggg cagcgaggcc aacctgacct gcaccctgac cggcctgagg      420

gacgccagcg gcgccacctt cacctggacc cccagcagcg gcaagagcgc cgtgcagggc      480

ccccccgaga gggacctgtg cggctgctac agcgtgagca gcgtgctgcc cggctgcgcc      540

cagccctgga accacggcga gaccttcacc tgcaccgccg cccaccccga gctgaagacc      600

cccctgaccg ccaacatcac caagagcggc aacaccttca ggcccgaggt gcacctgctg      660

ccccccccca gcgaggagct ggccctgaac gagctggtga ccctgacctg cctggccagg      720

ggcttcagcc ccaaggacgt gctggtgagg tggctgcagg gcagccagga gctgcccagg      780

gagaagtacc tgacctgggc cagcaggcag gagcccagcc agggcaccac cacctacgcc      840

gtgaccagca tcctgagggt ggccgccgag gactggaaga agggcgagac cttcagctgc      900

atggtgggcc acgaggccct gcccctggcc ttcacccaga agaccatcga caggatggcc      960

ggcagctgct gcgtggccga ctggcagatg ccccccccct acgtggtgct ggacctgccc     1020

caggagaccc tggaggagga gacccccggc gccaacctgt ggcccaccac catcaccttc     1080

ctgaccctgt tcctgctgag cctgttctac agcaccgccc tgaccgtgac cagcgtgagg     1140

ggccccagcg gcaagaggga gggcccccag tac                                  1173


<210>  25
<211>  1014
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA3.0+

<400>  25
gctagcccaa cctctcctaa ggtgttccct ctgagcctgg acagcacccc tcaggatgga       60

aatgtggtgg tggcctgtct ggtgcaggga ttcttcccac aagagcccct gtccgtgact      120

tggagcgaat ctggacaggg cgtgaccgcc agaaacttcc caccttctca ggacgcctct      180

ggcgacctgt acaccacctc ttctcagctg accctgcctg ccacacagtg ccctgatggc      240

aagtctgtga cctgccacgt gaagcactac accaatccta gccaggacgt gaccgtgcct      300

tgcagagttc ctcctcctcc accttgctgt caccctcggc tgtctctgca cagacccgct      360

ctggaagatc tgctgctggg ctctgaggcc aacctgacat gtaccctgac cggcctgaga      420

gatgcttctg gcgccacctt tacctggaca ccttccagcg gaaagtccgc tgttcaggga      480

cctcctgaga gggacctgtg cggctgttac tctgtgtcta gtgtgctgcc tggcagcgcc      540

cagccttgga atcatggcga gacattcacc tgtaccgctg ctcaccccga gctgaaaacc      600

cctctgaccg ccacactgtc caagtccggc aacaccttcc ggcctgaagt gcatctgctg      660

cctccaccta gcgaggaact ggccctgaat gagctggtca ccctgacctg tctggccagg      720

ggctttagcc ctaaggacgt gctcgttaga tggctgcagg gctcccaaga gctgcccaga      780

gagaagtatc tgacctgggc ctctcggcaa gagccatctc agggcaccac aacctttgcc      840

gtgaccagca tcctgagagt ggccgccgaa gattggaaga agggcgacac cttcagctgc      900

atggtcggac atgaagccct gcctctggct ttcacccaga aaaccatcga cagactggcc      960

ggcaagccca cccatgtcca agtgtctgtt gtcatggcgg aggtggacgg cacc           1014


<210>  26
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA3.0min

<400>  26
gctagcccaa cctctcctaa ggtgttccct ctgagcctgg acagcacccc tcaggatgga       60

aatgtggtgg tggcctgtct ggtgcaggga ttcttcccac aagagcccct gtccgtgact      120

tggagcgaat ctggacaggg cgtgaccgcc agaaacttcc caccttctca ggacgcctct      180

ggcgacctgt acaccacctc ttctcagctg accctgcctg ccacacagtg ccctgatggc      240

aagtctgtga cctgccacgt gaagcactac accaatccta gccaggacgt gaccgtgcct      300

tgcagagttc ctcctcctcc accttgctgt caccctcggc tgtctctgca cagacccgct      360

ctggaagatc tgctgctggg ctctgaggcc aacctgacat gtaccctgac cggcctgaga      420

gatgcttctg gcgccacctt tacctggaca ccttccagcg gaaagtccgc tgttcaggga      480

cctcctgaga gggacctgtg cggctgttac tctgtgtcta gtgtgctgcc tggcagcgcc      540

cagccttgga atcatggcga gacattcacc tgtaccgctg ctcaccccga gctgaaaacc      600

cctctgaccg ccacactgtc caagtccggc aacaccttcc ggcctgaagt gcatctgctg      660

cctccaccta gcgaggaact ggccctgaat gagctggtca ccctgacctg tctggccagg      720

ggctttagcc ctaaggacgt gctcgttaga tggctgcagg gctcccaaga gctgcccaga      780

gagaagtatc tgacctgggc ctctcggcaa gagccatctc agggcaccac aacctttgcc      840

gtgaccagca tcctgagagt ggccgccgaa gattggaaga agggcgacac cttcagctgc      900

atggtcggac atgaagccct gcctctggct ttcacccaga aaaccatcga cagactggcc      960

ggcaag                                                                 966


<210>  27
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NG

<400>  27
gctagcccaa cctctcctaa ggtgttccct ctgagcctgg acagcacccc tcaggatgga       60

aatgtggtgg tggcctgtct ggtgcaggga ttcttcccac aagagcccct gtccgtgact      120

tggagcgaat ctggacaggg cgtgaccgcc agaaacttcc caccttctca ggacgcctct      180

ggcgacctgt acaccacctc ttctcagctg accctgcctg ccacacagtg ccctgatggc      240

aagtctgtga cctgccacgt gaagcactac accaatccta gccaggacgt gaccgtgcct      300

tgcagagttc ctcctcctcc accttgctgt caccctcggc tgtctctgca cagacccgct      360

ctggaagatc tgctgctggg ctctgaggcc ggcctgacat gtaccctgac cggcctgaga      420

gatgcttctg gcgccacctt tacctggaca ccttccagcg gaaagtccgc tgttcaggga      480

cctcctgaga gggacctgtg cggctgttac tctgtgtcta gtgtgctgcc tggcagcgcc      540

cagccttgga atcatggcga gacattcacc tgtaccgctg ctcaccccga gctgaaaacc      600

cctctgaccg ccacactgtc caagtccggc aacaccttcc ggcctgaagt gcatctgctg      660

cctccaccta gcgaggaact ggccctgaat gagctggtca ccctgacctg tctggccagg      720

ggctttagcc ctaaggacgt gctcgttaga tggctgcagg gctcccaaga gctgcccaga      780

gagaagtatc tgacctgggc ctctcggcaa gagccatctc agggcaccac aacctttgcc      840

gtgaccagca tcctgagagt ggccgccgaa gattggaaga agggcgacac cttcagctgc      900

atggtcggac atgaagccct gcctctggct ttcacccaga aaaccatcga cagactggcc      960

ggcaag                                                                 966


<210>  28
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NQ

<400>  28
gctagcccaa cctctcctaa ggtgttccct ctgagcctgg acagcacccc tcaggatgga       60

aatgtggtgg tggcctgtct ggtgcaggga ttcttcccac aagagcccct gtccgtgact      120

tggagcgaat ctggacaggg cgtgaccgcc agaaacttcc caccttctca ggacgcctct      180

ggcgacctgt acaccacctc ttctcagctg accctgcctg ccacacagtg ccctgatggc      240

aagtctgtga cctgccacgt gaagcactac accaatccta gccaggacgt gaccgtgcct      300

tgcagagttc ctcctcctcc accttgctgt caccctcggc tgtctctgca cagacccgct      360

ctggaagatc tgctgctggg ctctgaggcc cagctgacat gtaccctgac cggcctgaga      420

gatgcttctg gcgccacctt tacctggaca ccttccagcg gaaagtccgc tgttcaggga      480

cctcctgaga gggacctgtg cggctgttac tctgtgtcta gtgtgctgcc tggcagcgcc      540

cagccttgga atcatggcga gacattcacc tgtaccgctg ctcaccccga gctgaaaacc      600

cctctgaccg ccacactgtc caagtccggc aacaccttcc ggcctgaagt gcatctgctg      660

cctccaccta gcgaggaact ggccctgaat gagctggtca ccctgacctg tctggccagg      720

ggctttagcc ctaaggacgt gctcgttaga tggctgcagg gctcccaaga gctgcccaga      780

gagaagtatc tgacctgggc ctctcggcaa gagccatctc agggcaccac aacctttgcc      840

gtgaccagca tcctgagagt ggccgccgaa gattggaaga agggcgacac cttcagctgc      900

atggtcggac atgaagccct gcctctggct ttcacccaga aaaccatcga cagactggcc      960

ggcaag                                                                 966


<210>  29
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NT

<400>  29
gctagcccaa cctctcctaa ggtgttccct ctgagcctgg acagcacccc tcaggatgga       60

aatgtggtgg tggcctgtct ggtgcaggga ttcttcccac aagagcccct gtccgtgact      120

tggagcgaat ctggacaggg cgtgaccgcc agaaacttcc caccttctca ggacgcctct      180

ggcgacctgt acaccacctc ttctcagctg accctgcctg ccacacagtg ccctgatggc      240

aagtctgtga cctgccacgt gaagcactac accaatccta gccaggacgt gaccgtgcct      300

tgcagagttc ctcctcctcc accttgctgt caccctcggc tgtctctgca cagacccgct      360

ctggaagatc tgctgctggg ctctgaggcc accctgacat gtaccctgac cggcctgaga      420

gatgcttctg gcgccacctt tacctggaca ccttccagcg gaaagtccgc tgttcaggga      480

cctcctgaga gggacctgtg cggctgttac tctgtgtcta gtgtgctgcc tggcagcgcc      540

cagccttgga atcatggcga gacattcacc tgtaccgctg ctcaccccga gctgaaaacc      600

cctctgaccg ccacactgtc caagtccggc aacaccttcc ggcctgaagt gcatctgctg      660

cctccaccta gcgaggaact ggccctgaat gagctggtca ccctgacctg tctggccagg      720

ggctttagcc ctaaggacgt gctcgttaga tggctgcagg gctcccaaga gctgcccaga      780

gagaagtatc tgacctgggc ctctcggcaa gagccatctc agggcaccac aacctttgcc      840

gtgaccagca tcctgagagt ggccgccgaa gattggaaga agggcgacac cttcagctgc      900

atggtcggac atgaagccct gcctctggct ttcacccaga aaaccatcga cagactggcc      960

ggcaag                                                                 966


<210>  30
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA4.0_NLT-TIS

<400>  30
gctagcccaa cctctcctaa ggtgttccct ctgagcctgg acagcacccc tcaggatgga       60

aatgtggtgg tggcctgtct ggtgcaggga ttcttcccac aagagcccct gtccgtgact      120

tggagcgaat ctggacaggg cgtgaccgcc agaaacttcc caccttctca ggacgcctct      180

ggcgacctgt acaccacctc ttctcagctg accctgcctg ccacacagtg ccctgatggc      240

aagtctgtga cctgccacgt gaagcactac accaatccta gccaggacgt gaccgtgcct      300

tgcagagttc ctcctcctcc accttgctgt caccctcggc tgtctctgca cagacccgct      360

ctggaagatc tgctgctggg ctctgaggcc accatcagct gtaccctgac cggcctgaga      420

gatgcttctg gcgccacctt tacctggaca ccttccagcg gaaagtccgc tgttcaggga      480

cctcctgaga gggacctgtg cggctgttac tctgtgtcta gtgtgctgcc tggcagcgcc      540

cagccttgga atcatggcga gacattcacc tgtaccgctg ctcaccccga gctgaaaacc      600

cctctgaccg ccacactgtc caagtccggc aacaccttcc ggcctgaagt gcatctgctg      660

cctccaccta gcgaggaact ggccctgaat gagctggtca ccctgacctg tctggccagg      720

ggctttagcc ctaaggacgt gctcgttaga tggctgcagg gctcccaaga gctgcccaga      780

gagaagtatc tgacctgggc ctctcggcaa gagccatctc agggcaccac aacctttgcc      840

gtgaccagca tcctgagagt ggccgccgaa gattggaaga agggcgacac cttcagctgc      900

atggtcggac atgaagccct gcctctggct ttcacccaga aaaccatcga cagactggcc      960

ggcaag                                                                 966


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kappa light chain constant domain

<400>  31

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  32
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  kappa light chain constant domain

<400>  32
cggacagtgg ccgctccttc cgtgttcatc ttcccacctt ccgacgagca gctgaagtcc       60

ggcacagcta gcgtggtctg cctgctgaac aacttctacc ctcgggaagc caaggtgcag      120

tggaaggtgg acaatgccct gcagtccggc aactcccaag agtctgtgac cgagcaggac      180

tccaaggaca gcacctacag cctgtcctcc acactgaccc tgtccaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaagtgacc catcagggcc tgtctagccc tgtgaccaag      300

tctttcaacc ggggcgagtg t                                                321


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Obinutuzumab

<400>  33

Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Dinutuximab (also called Ch14.18 or Unituxin)

<400>  34

Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 Trastuzumab

<400>  35

Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 TA99

<400>  36

Gly Phe Asn Ile Lys Asp Tyr Phe Leu His 
1               5                   10  


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  37

Gly Tyr Ser Ile Thr Ser Gly Tyr Gly Trp Asn 
1               5                   10      


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 2.3D11

<400>  38

Ser Gly Val Ser Ile Arg Ser Ile Asn Trp Trp Asn 
1               5                   10          


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 C47A8-CQ

<400>  39

Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10      


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 UMAB10

<400>  40

Gly Phe Thr Phe Pro Ser Tyr Asn Leu His 
1               5                   10  


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Obinutuzumab

<400>  41

Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Dinutuximab (also called Ch14.18 or Unituxin)

<400>  42

Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Trastuzumab

<400>  43

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 TA99

<400>  44

Trp Ile Asn Pro Asp Asn Gly Asn Thr Val Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  45

Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile Lys Ser 
1               5                   10                  15      


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 2.3D11

<400>  46

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 C47A8-CQ

<400>  47

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 UMAB10

<400>  48

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Obinutuzumab

<400>  49

Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr 
1               5                   10  


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Dinutuximab (also called Ch14.18 or Unituxin)

<400>  50

Gly Met Glu Tyr 
1               


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 Trastuzumab

<400>  51

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 TA99

<400>  52

Arg Asp Tyr Thr Tyr Glu Lys Ala Ala Leu Asp Tyr 
1               5                   10          


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  53

Gln Thr Gly Tyr Phe Asp Tyr 
1               5           


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 2.3D11

<400>  54

Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15      


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 C47A8-CQ

<400>  55

Ser Thr Leu Trp Phe Ser Glu Phe Asp Tyr 
1               5                   10  


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 UMAB10

<400>  56

Ser Ala Tyr Tyr Gly Ser Asn Val Trp Phe Phe Asp Val 
1               5                   10              


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 Obinutuzumab

<400>  57

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 Dinutuximab (also called Ch14.18 or Unituxin)

<400>  58

Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 Trastuzumab

<400>  59

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 TA99

<400>  60

Arg Ala Ser Gly Asn Ile Tyr Asn Tyr Leu Ala 
1               5                   10      


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1

<400>  61

Lys Ser Ser Gln Ser Leu Phe Asn Ser Asn Ala Lys Thr Asn Tyr Leu 
1               5                   10                  15      


Asn 
    


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 2.3D11

<400>  62

Arg Ala Ser Glu Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 C47A8-CQ

<400>  63

Ser Gly Thr Ser Ser Asp Val Gly Gly His Asn Tyr Val Ser 
1               5                   10                  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 UMAB10

<400>  64

Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
1               5                   10  


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 Obinutuzumab

<400>  65

Gln Met Ser Asn Leu Val Ser 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 Dinutuximab (also called Ch14.18 or Unituxin)

<400>  66

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 Trastuzumab

<400>  67

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 TA99

<400>  68

Asp Ala Lys Thr Leu Ala Asp 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2

<400>  69

Tyr Ala Ser Thr Arg His Thr 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 2.3D11

<400>  70

Gly Ala Phe Asn Arg Ala Thr 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 C47A8-CQ

<400>  71

Asp Val Thr Lys Arg Pro Ser 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 UMAB10

<400>  72

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 Obinutuzumab

<400>  73

Ala Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 Dinutuximab (also called Ch14.18 or Unituxin)

<400>  74

Ser Gln Ser Thr His Val Pro Pro Leu Thr 
1               5                   10  


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 Trastuzumab

<400>  75

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 TA99

<400>  76

Gln His Phe Trp Ser Leu Pro 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3

<400>  77

Gln Gln Trp Tyr Asp Tyr Pro Tyr Thr 
1               5                   


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 2.3D11

<400>  78

Gln Gln Arg Ser Asp Trp Phe Thr 
1               5               


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 C47A8-CQ

<400>  79

Gln Ser Tyr Ala Gly Ser Arg Val Tyr Val 
1               5                   10  


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 UMAB10

<400>  80

Gln Gln Trp Ile Ser Asn Pro Pro Thr 
1               5                   


<210>  81
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Obinutuzu-mab

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  82
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  83
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TA99

<400>  83

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Asn Gly Asn Thr Val Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Thr Ala Ser Leu Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Arg Asp Tyr Thr Tyr Glu Lys Ala Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Thr 
        115                 120     


<210>  84
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab

<400>  84

Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln Lys Val Glu Trp 
        35                  40                  45              


Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  85
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11

<400>  85

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile Arg Ser Ile 
            20                  25                  30          


Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  86
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C47A8-CQ

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Leu Trp Phe Ser Glu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Obinutuzumab

<400>  87
caggtgcaat tggtgcagtc tggcgctgaa gttaagaagc ctgggagttc agtgaaggtc       60

tcctgcaagg cttccggata cgccttcagc tattcttgga tcaattgggt gcggcaggcg      120

cctggacaag ggctcgagtg gatgggacgg atctttcccg gcgatgggga tactgactac      180

aatgggaaat tcaagggcag agtcacaatt accgccgaca aatccactag cacagcctat      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagaaatgtc      300

tttgatggtt actggcttgt ttactggggc cagggaaccc tggtcaccgt ctcgaca         357


<210>  88
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dinutuximab (also called Ch14.18 or Unituxin)

<400>  88
gaagtgcagc tggtgcagag cggcgcggaa gtggaaaaac cgggcgcgag cgtgaaaatt       60

agctgcaaag cgagcggcag cagctttacc ggctataaca tgaactgggt gcgccagaac      120

attggcaaaa gcctggaatg gattggcgcg attgatccgt attatggcgg caccagctat      180

aaccagaaat ttaaaggccg cgcgaccctg accgtggata aaagcaccag caccgcgtat      240

atgcatctga aaagcctgcg cagcgaagat accgcggtgt attattgcgt gagcggcatg      300

gaatattggg gccagggcac cagcgtgacc gtgagcagc                             339


<210>  89
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Trastuzumab

<400>  89
gaggtgcagc tggtcgagag cggcggaggg ctggtgcagc caggcggcag cctgaggctg       60

tcctgcgccg ccagcggctt caacatcaag gacacctaca tccactgggt gcggcaggcc      120

ccaggcaagg gcctggagtg ggtggccagg atctacccca ccaacggcta caccagatac      180

gccgacagcg tgaagggcag gttcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcag cagatggggc      300

ggggacggct tctacgctat ggactactgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  90
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TA99

<400>  90
gaggttcagt tgcagcagtc tggcgccgaa ctcgttagac ctggcgctct ggttaagctg       60

tcctgcaaga cctccggctt caatatcaag gactacttcc tgcactgggt ccgacagagg      120

cctgaccaag gactggaatg gatcggctgg atcaaccccg acaacggcaa caccgtgtac      180

gaccctaagt tccagggcac cgcttctctg accgccgaca cctcttccaa taccgtgtac      240

ctgcagctgt ccggcctgac ctctgaggat accgccgtgt acttctgcac cagacgggac      300

tacacctacg agaaggccgc tctggattat tggggccagg gcacaaccgt gaccgtgtct      360

aca                                                                    363


<210>  91
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ab

<400>  91
caggtgaaac tggaagaaag cggcccgggc ctggtgaacc cgagccagag cctgagcctg       60

agctgcagcg tgaccggcta tagcattacc agcggctatg gctggaactg gattcgccag      120

tttccgggcc agaaagtgga atggatgggc tttatttatt atgaaggcag cacctattat      180

aacccgagca ttaaaagccg cattagcatt acccgcgata ccagcaaaaa ccagtttttt      240

ctgcaggtga acagcgtgac caccgaagat accgcgacct attattgcgc gcgccagacc      300

ggctattttg attattgggg ccagggcacc atggtgaccg tgagcagcgg tgagtgc         357


<210>  92
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.3D11

<400>  92
caggtgcagc tgcaggaaag cggcccgggc ctggtgaaac cgagcggcac cctgagcctg       60

acctgcgcgg tgagcggcgt gagcattcgc agcattaact ggtggaactg ggtgcgccag      120

ccgccgggca aaggcctgga atggattggc gaaatttatc atagcggcag caccaactat      180

aacccgagcc tgaaaagccg cgtgaccatt agcgtggata aaagcaaaaa ccagtttagc      240

ctgaaactga acagcgtgac cgcggcggat accgcggtgt attattgcgc gcgcgatggc      300

ggcattgcgg tgaccgatta ttattattat ggcctggatg tgtggggcca gggcaccacc      360

gtgaccgtga gcagc                                                       375


<210>  93
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C47A8-CQ

<400>  93
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc agctattata tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatgggcatt attaacccga gcggcggcag caccagctat      180

gcgcagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcagcacc      300

ctgtggttta gcgaatttga ttattggggc cagggcaccc tggtgaccgt gagcagc         357


<210>  94
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UMAB10

<400>  94
caagcctacc tgcagcagtc tggcgccgat ctcgtgcggc ctggcgcctc tgtgaagatg       60

agctgtaaag ccagcggctt caccttcccc agctacaacc tgcactgggt caagcagacc      120

cccagacagg gcctggaatg gatcggagcc atctaccccg gcaacggcga cacctcctac      180

aaccagaagt tcaagggcaa ggccaccctg accgtggaca agagcagcag caccgcctac      240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt acttctgtgc cagaagcgcc      300

tactacggca gcaacgtgtg gttcttcgac gtgtggggca ccggcaccac cgtgacagtg      360

tcatct                                                                 366


<210>  95
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Obinutuzu-mab

<400>  95

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  96
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  97
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TA99

<400>  97

Ile Gln Met Ser Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile Tyr Asn Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val Tyr 
        35                  40                  45              


Asp Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Ser Leu Gln Thr Glu 
65                  70                  75                  80  


Asp Ser Gly Asn Tyr Tyr Cys Gln His Phe Trp Ser Leu Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  98
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab

<400>  98

Asp Val Met Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Asn Tyr Leu Asn Trp Tyr Met Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Thr Tyr Tyr Ala Ser Thr Arg His Thr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Asp Glu Asp Gln Ala Phe Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Trp Tyr Asp Tyr Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  99
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11

<400>  99

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  100
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C47A8-CQ

<400>  100

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Ser Ser Asp Val Gly Gly His 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ser 
                85                  90                  95      


Arg Val Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  101
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Obinutuzumab

<400>  101
gatatcgtga tgacccagac acctctgagc ctgcctgtga cacctggcga gcctgcttcc       60

atctcctgcc ggtcctctaa gtccctgctg cactctaacg gcatcaccta cctgtactgg      120

tatctgcaga agcccggcca gtctcctcag ctgctgatct accagatgtc caacctggtg      180

tctggcgtgc ccgacagatt ttccggctct ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactattgtg cccagaacct ggaactgccc      300

tacacctttg gcggaggcac caaggtggaa atcaag                                336


<210>  102
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dinutuximab (also called Ch14.18 or Unituxin)

<400>  102
gaaattgtga tgacccagag cccggcgacc ctgagcgtga gcccgggcga acgcgcgacc       60

ctgagctgcc gcagcagcca gagcctggtg catcgcaacg gcaacaccta tctgcattgg      120

tatctgcaga aaccgggcca gagcccgaaa ctgctgattc ataaagtgag caaccgcttt      180

agcggcgtgc cggatcgctt tagcggcagc ggcagcggca ccgattttac cctgaaaatt      240

agccgcgtgg aagcggaaga tctgggcgtg tatttttgca gccagagcac ccatgtgccg      300

ccgctgacct ttggcgcggg caccaaactg gaactgaaa                             339


<210>  103
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Trastuzumab

<400>  103
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgta gagccagcca ggacgtgaac accgccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctccttcc tgtactctgg cgtgccctcc      180

agattctccg gcagcagatc tggcaccgac tttaccctga caatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag cactacacca cacctccaac ctttggccag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  104
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TA99

<400>  104
atccagatga gtcagtctcc ggcctcccta tctgcatctg tgggagaaac tgtcaccatc       60

acatgtcgag caagtggaaa tatttacaat tatttagcat ggtatcagca gaaacaggga      120

aaatctcctc acctcctggt ctatgatgca aaaaccttag cagatggtgt gccatcaagg      180

ttcagtggca gtggctcagg gacacaatat tctctcaaga ttagcagcct tcagactgaa      240

gattctggga attattactg tcaacatttt tggagtcttc cattcacgtt cggctcgggg      300

accaagctgg aaataaaa                                                    318


<210>  105
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ab

<400>  105
gatgtgatga tgacccagag cccgagcagc atgagcgtga gcgcgggcga aaaagcgacc       60

attagctgca aaagcagcca gagcctgttt aacagcaacg cgaaaaccaa ctatctgaac      120

tggtatatgc agaaaccggg ccagagcccg aaactgctga cctattatgc gagcacccgc      180

cataccggcg tgccggatcg ctttcgcggc agcggcagcg gcaccgattt taccctgacc      240

attagcagcg tgcaggatga agatcaggcg ttttattatt gccagcagtg gtatgattat      300

ccgtatacct ttggcgcggg caccaaactg gaaattaaa                             339


<210>  106
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.3D11

<400>  106
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcgcgagcga aagcgtgagc agcaacctgg cgtggtatca gcagaaaccg      120

ggccaggcgc cgcgcctgct gatttatggc gcgtttaacc gcgcgaccgg cattccggcg      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg      240

gaagattttg cggtgtatta ttgccagcag cgcagcgatt ggtttacctt tggcggcggc      300

accaaagtgg aaattaaa                                                    318


<210>  107
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C47A8-CQ

<400>  107
cagagcgtgc tgacccagcc gagcagcgtg agcgcgagcc cgggccagag cattaccatt       60

agctgcagcg gcaccagcag cgatgtgggc ggccataact atgtgagctg gtatcagcag      120

catccgggca aagcgccgaa actgatgatt tatgatgtga ccaaacgccc gagcggcgtg      180

ccggatcgct ttagcggcag caaaagcggc aacaccgcga gcctgaccgt gagcggcctg      240

caggcggaag atgaagcgga ttattattgc cagagctatg cgggcagccg cgtgtatgtg      300

tttggcaccg gcaccaaact gaccgtgctg                                       330


<210>  108
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UMAB10

<400>  108
cagatcgtgc tgagccagag ccccgccatc ctgagtgcta gccctggcga gaaagtgacc       60

atgacctgca gagccagcag cagcgtgtcc tacatggact ggtatcagca gaagcccggc      120

agcagcccca agccctggat ctacgccaca agcaatctgg ccagcggcgt gcccacaaga      180

ttttccggca gcggctctgg caccagctac agcctgacca tcagccgggt ggaagccgaa      240

gatgccgcca cctactactg ccagcagtgg atcagcaacc cccccacctt tggagccggc      300

accaagctgg atctgaag                                                    318


<210>  109
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1 domain of WT IgA2 heavy chain constant region

<400>  109

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro 
            100         


<210>  110
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2 domain of WT IgA2 heavy chain constant region

<400>  110

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser 
            100     


<210>  111
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3 domain of WT IgA2 heavy chain constant region including 
       C-terminal Tail-piece

<400>  111

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  integrin-binding peptide

<400>  112

Cys Tyr Gly Gly Arg Gly Asp Thr Pro 
1               5                   


<210>  113
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F CH1 gDNA

<400>  113

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro 
            100         


<210>  114
<211>  307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgHA2*01 F CH1 gDNA

<400>  114
gcatccccga ccagccccaa ggtcttcccg ctgagcctcg acagcacccc ccaagatggg       60

aacgtggtcg tcgcatgcct ggtccagggc ttcttccccc caggagccac tcagtgtgac      120

ctggagcgaa agcggacaga acgtgaccgc cagaaacttc ccacctagcc aggatgcctc      180

cggggacctg tacaccacga gcagccagct gaccctgccg gccacacagt gcccagacgg      240

caagtccgtg acatgccacg tgaagcacta cacgaatccc agccaggatg tgactgtgcc      300

ctgccca                                                                307


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F H gDNA

<400>  115

Val Pro Pro Pro Pro Pro 
1               5       


<210>  116
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F H gDNA

<400>  116
gttcccccac ctccccca                                                     18


<210>  117
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F CH2 gDNA

<400>  117

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser 
            100     


<210>  118
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F CH2 gDNA

<400>  118
tgctgccacc cccgactgtc gctgcaccga ccggccctcg aggacctgct cttaggttca       60

gaagcgaacc tcacgtgcac actgaccggc ctgagagatg cctctggtgc caccttcacc      120

tggacgccct caagtgggaa gagcgctgtt caaggaccac ctgagcgtga cctctgtggc      180

tgctacagcg tgtccagtgt cctgcctggc tgtgcccagc catggaacca tggggagacc      240

ttcacctgca ctgctgccca ccccgagttg aagaccccac taaccgccaa catcacaaaa      300

tcc                                                                    303


<210>  119
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F CH3-CH3 gDNA

<400>  119

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  120
<211>  394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHA2*01 F CH3-CHS gDNA

<400>  120
ggaaacacat tccggcccga ggtccacctg ctgccgccgc cgtcggagga gctggccctg       60

aacgagctgg tgacgctgac gtgcctggca cgtggcttca gccccaagga tgtgctggtt      120

cgctggctgc aggggtcaca ggagctgccc cgcgagaagt acctgacttg ggcatcccgg      180

caggagcccc agccagggca ccaccacctt cgctgtgacc agcatactgc gcgtggcagc      240

cgaggactgg aagaaggggg acaccttctc ctgcatggtg ggccacgagg ccctgccgct      300

ggccttcaca cagaagacca tcgaccgctt ggcgggtaaa cccacccatg tcaatgtgtc      360

tgtttgcatg gcggaggtgg acggcacctg ctac                                  394


<210>  121
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  121

Gln Ile Val Leu Ser Gln Ser Pro Ala Val Leu Phe Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120     


