<110>    Missionary Benedictine Sisters, INC.

<120>    In vitro osteoarthritis condition model and drug screening method
         for osteoarthritis using the same

<130>    OP19-0057/PCT

<150>    KR 10-2019-0033949
<151>    2019-03-25

<160>    92

<170>    KoPatentIn 3.0

<210>    1
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Sox9 Forward


<400>    1
cagccccttc aaccttcctc                                                     20


<210>    2
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Sox9 Reverse


<400>    2
tgatggtcag cgtagtcgta tt                                                  22


<210>    3
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col2 Forward


<400>    3
cggtcctacg gtgtcagg                                                       18


<210>    4
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col2 Reverse


<400>    4
ttatacctct gcccattctg c                                                   21


<210>    5
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Agc Forward


<400>    5
ccagcctaca ccccagtg                                                       18


<210>    6
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Agc Reverse


<400>    6
gagggtggga agccatgt                                                       18


<210>    7
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ihh Forward


<400>    7
tgcattgctc tgtcaagtct g                                                   21


<210>    8
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ihh Reverse


<400>    8
gctccccgtt ctctaggc                                                       18


<210>    9
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col10 Forward


<400>    9
gcatctccca gcaccaga                                                       18


<210>    10
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col10 Reverse


<400>    10
ccatgaacca gggtcaagaa                                                     20


<210>    11
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Mmp13 Forward


<400>    11
gccagaactt cccaaccat                                                      19


<210>    12
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Mmp13 Reverse


<400>    12
tcagagccca gaattttctc c                                                   21


<210>    13
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Runx2 Forward


<400>    13
gcccaggcgt atttcaga                                                       18


<210>    14
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Runx2 Reverse


<400>    14
tgcctggctc ttcttactga g                                                   21


<210>    15
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col1a1 Forward


<400>    15
cttcacctac agcacccttg tg                                                  22


<210>    16
<211>    24
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col1a1 Reverse


<400>    16
ttggtggttt tgtattcgat gact                                                24


<210>    17
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Atf4 Forward


<400>    17
tcgatgctct gtttcgaatg g                                                   21


<210>    18
<211>    24
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Atf4 Reverse


<400>    18
aagatcacat gtgtcatcca acgt                                                24


<210>    19
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gadd45b Forward


<400>    19
gaggatgata tcgctctgca gat                                                 23


<210>    20
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gadd45b Reverse


<400>    20
acccggacga tgtcaatgtc                                                     20


<210>    21
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Axin2 Forward


<400>    21
gacgcactga ccgacgatt                                                      19


<210>    22
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Axin2 Reverse


<400>    22
ttcttactcc ccatgcggta a                                                   21


<210>    23
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Wisp1 Forward


<400>    23
gacctgaccg agttgcctaa tg                                                  22


<210>    24
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Wisp1 Reverse


<400>    24
gcgaagtctt ccccatcgt                                                      19


<210>    25
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Wnt5a Forward


<400>    25
cattggagaa ggtgcgaaga c                                                   21


<210>    26
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Wnt5a Reverse


<400>    26
ccactgtgct gcagttccat                                                     20


<210>    27
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Csf1 Forward


<400>    27
tcctcatgag caggagtatt gc                                                  22


<210>    28
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Csf1 Reverse


<400>    28
caggaccttc aggtgtccat tc                                                  22


<210>    29
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Stat1 Forward


<400>    29
tgagatgtcc cggatagtgg                                                     20


<210>    30
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Stat1 Reverse


<400>    30
cgccagagag aaattcgtgt                                                     20


<210>    31
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Irf1 Forward


<400>    31
ggaagggaag atagccgaag a                                                   21


<210>    32
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Irf1 Reverse


<400>    32
atcccttgcc atcgatgtgt                                                     20


<210>    33
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Socs3 Forward


<400>    33
ccgcttcgac tgtgtactca ag                                                  22


<210>    34
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Socs3 Reverse


<400>    34
ccgtgggtgg caaagaaa                                                       18


<210>    35
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gata3a Forward


<400>    35
cggaagaggt ggacgtactt tt                                                  22


<210>    36
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gata3a Reverse


<400>    36
cgtagccctg acggagtttc                                                     20


<210>    37
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Bax Forward


<400>    37
gtgagcggct gcttgtct                                                       18


<210>    38
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Bax Reverse


<400>    38
ggtcccgaag taggagagga                                                     20


<210>    39
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ccnd1 Forward


<400>    39
gcgtaccctg acaccaatct c                                                   21


<210>    40
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ccnd1 Reverse


<400>    40
ctcctcttcg cacttctgct c                                                   21


<210>    41
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pcna Forward


<400>    41
tttgaggcac gcctgatcc                                                      19


<210>    42
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pcna Reverse


<400>    42
ggagacgtga gacgagtcca t                                                   21


<210>    43
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hes1 Forward


<400>    43
ccagccagtg tcaacacga                                                      19


<210>    44
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hes1 Reverse


<400>    44
aatgccggga gctatctttc t                                                   21


<210>    45
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hey1 Forward


<400>    45
gcgcggacga gaatggaaa                                                      19


<210>    46
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hey1 Reverse


<400>    46
tcaggtgatc cacagtcatc tg                                                  22


<210>    47
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ptch1 Forward


<400>    47
ggaaggggca aagctacagt                                                     20


<210>    48
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ptch1 Reverse


<400>    48
tccaccgtaa aggaggctta                                                     20


<210>    49
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gli1 Forward


<400>    49
ctgactgtgc ccgagagtg                                                      19


<210>    50
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gli1 Reverse


<400>    50
cgctgctgca agaggact                                                       18


<210>    51
<211>    24
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hhip Forward


<400>    51
cccagactca caatggaaaa ctct                                                24


<210>    52
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hhip Reverse


<400>    52
ggtgtagtag ccgtttcgac aga                                                 23


<210>    53
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Fth1 Forward


<400>    53
tgaccacgtg accaacttac g                                                   21


<210>    54
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Fth1 Reverse


<400>    54
ccagggtgtg cttgtcaaag a                                                   21


<210>    55
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hmox1 Forward


<400>    55
tgaccacgtg accaacttac g                                                   21


<210>    56
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hmox1 Reverse


<400>    56
ccagggtgtg cttgtcaaag a                                                   21


<210>    57
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Txn Forward


<400>    57
atcaagccct tcttccattc c                                                   21


<210>    58
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Txn Reverse


<400>    58
tcctggcagt catccacatc                                                     20


<210>    59
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Arnt Forward


<400>    59
cctggctcga aaaccagaca                                                     20


<210>    60
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Arnt Reverse


<400>    60
tgttgccagt tcccctcaag                                                     20


<210>    61
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Serpine1 Forward


<400>    61
atgactgggt ggaaaggcat ac                                                  22


<210>    62
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Serpine1 Reverse


<400>    62
caggcgtgtc agctcgtcta                                                     20


<210>    63
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Vegfa Forward


<400>    63
gcagcttgag ttaaacgaac g                                                   21


<210>    64
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Vegfa Reverse


<400>    64
ggttcccgaa accctgag                                                       18


<210>    65
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Cycs Forward


<400>    65
ggtgatgttg aaaaaggcaa gaa                                                 23


<210>    66
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Cycs Reverse


<400>    66
ttatgcttgc ctcccttttc c                                                   21


<210>    67
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    AtpsynF1 Forward


<400>    67
cctggaatta tcccccgaat                                                     20


<210>    68
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    AtpsynF1 Reverse


<400>    68
ccaatgggca ccaggctat                                                      19


<210>    69
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Cox4i Forward


<400>    69
tcactgcgct cgttctgat                                                      19


<210>    70
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Cox4i Reverse


<400>    70
cgatcgaaag tatgagggat g                                                   21


<210>    71
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pepck Forward


<400>    71
ctggccaaga ttggtattga act                                                 23


<210>    72
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pepck Reverse


<400>    72
gatatgccca tccgagtcat g                                                   21


<210>    73
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    G6pase Forward


<400>    73
catgtaccgg aagagctgca a                                                   21


<210>    74
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    G6pase Reverse


<400>    74
ggaccaagga agccacaatg                                                     20


<210>    75
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Sod1 Forward


<400>    75
gcggtgaacc agttgtgttg                                                     20


<210>    76
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Sod1 Reverse


<400>    76
cccatactga tggacgtgga a                                                   21


<210>    77
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Sod2 Forward


<400>    77
ccacacatta acgcgcagat                                                     20


<210>    78
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Sod2 Reverse


<400>    78
tcggtggcgt tgagattgt                                                      19


<210>    79
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gpx1 Forward


<400>    79
aagtgcgaag tgaatggtga ga                                                  22


<210>    80
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gpx1 Reverse


<400>    80
gggtcgtcac tgggtgttg                                                      19


<210>    81
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Catalase Forward


<400>    81
ggcctcgcag agacctgat                                                      19


<210>    82
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Catalase Reverse


<400>    82
accccgcggt catgatatta                                                     20


<210>    83
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hk2 Forward


<400>    83
cacggagctc aaccaaaacc                                                     20


<210>    84
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Hk2 Reverse


<400>    84
ccggaaccgc ctagaaatct                                                     20


<210>    85
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ldha Forward


<400>    85
ctcaaggacc agctgattgt ga                                                  22


<210>    86
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Ldha Reverse


<400>    86
gcaccaaccc caacaactgt                                                     20


<210>    87
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pgk1 Forward


<400>    87
tggacaagct ggacgtgaag                                                     20


<210>    88
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pgk1 Reverse


<400>    88
gccttgatcc tttggttgtt tg                                                  22


<210>    89
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    iNos Forward


<400>    89
gcaagcatga cttccgagtg t                                                   21


<210>    90
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    iNos Reverse


<400>    90
gcccaaggta gagccatctg                                                     20


<210>    91
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gapdh Forward


<400>    91
tgtccgtcgt ggatctgac                                                      19


<210>    92
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Gapdh Reverse


<400>    92
cctgcttcac caccttcttg                                                     20
