                         SEQUENCE LISTING

<110>  GmbH, Medigene Immunotherapies
       Bluebird bio, Inc.
 
<120>  MAGE-A4-TCRs

<130>  MED16702PCT

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Ser Asp Gln Ser Tyr Gly 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Gly Ser Tyr Asp Glu Gln Asn 
1               5               


<210>  4
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Ala Met Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe 
1               5                   10                  


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gly His Asp Arg 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Phe Asp Val Lys Asp 
1               5       


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ala Thr Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr 
1               5                   10                  15      


Phe 
    


<210>  8
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His 
    130                 135     


<210>  9
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu 
    130                 135 


<210>  10
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with mininmal murinized constant region

<400>  10

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  11
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region

<400>  11

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe 
1               5                   10                  15  


<210>  15
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Gly Asp Leu Ser 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Ala Ser Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe 
1               5                   10              


<210>  18
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
        115                 120                 125             


Gly Thr Arg Leu Phe Val Lys Ala Asn 
    130                 135         


<210>  19
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  20
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with minimal  murinized constant region

<400>  20

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
        115                 120                 125             


Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  21
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region

<400>  21

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Arg Ser Tyr His Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  22
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ser Ala Ser Asn Tyr 
1               5       


<210>  23
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Arg Ser Asn Val Gly Glu 
1               5           


<210>  24
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Ala Ala Ser Arg Gly Thr Gly Phe Gln Lys Leu Val Phe 
1               5                   10                  


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Gly His Asp Thr 
1               5   


<210>  26
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  26

Tyr Asn Asn Lys Glu Leu 
1               5       


<210>  27
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Ala Ser Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe 
1               5                   10                  15      


<210>  28
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asn 
    130             


<210>  29
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr 
    130                 


<210>  30
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region

<400>  30

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  31
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region

<400>  31

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
            260                 265                 270         


His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe 
305                 310     


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized

<400>  32
accagcgatc agagctacgg c                                                 21


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  33
cagggcagct acgacgagca gaat                                              24


<210>  34
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  34
tgtgccatga gcggcgatag cgccggcaac atgcttacat tt                          42


<210>  35
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  35
aagggccacg accgg                                                        15


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  36
agcttcgacg tgaaggac                                                     18


<210>  37
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  37
tgcgccacca gcgactggga tagaagcggc gacaaagaga cacagtactt c                51


<210>  38
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region;  codon optimized

<400>  38
atgagcctga gcagcctgct gaaggtcgtg acagcctctc tgtggctcgg acctggaatc       60

gcccagaaga tcacccagac acagcccggc atgttcgtgc aagagaaaga agccgtgaca      120

ctggactgca cctacgacac cagcgatcag agctacggcc tgttctggta caagcagcct      180

agcagcggcg agatgatctt cctgatctac cagggcagct acgacgagca gaatgccacc      240

gagggcagat acagcctgaa cttccagaag gcccggaagt ccgccaacct ggtcatttct      300

gcttctcagc tgggcgacag cgccatgtac ttttgtgcca tgagcggcga tagcgccggc      360

aacatgctta catttggcgg cggaacccgg ctgatggtca agccccatat tcagaacccc      420

gatcctgccg tgtaccagct gagagacagc aagagcagcg acaagagcgt gtgtctgttc      480

accgacttcg acagccagac caacgtgtcc cagagcaagg acagcgacgt gtacatcacc      540

gacaagaccg tgctggacat gcggagcatg gacttcaaga gcaacagcgc cgtggcctgg      600

tccaacaaga gcgatttcgc ctgcgccaac gccttcaaca atagcattat ccccgaggac      660

acattcttcc ccagctccga tgtgccctgc gacgtgaagc tggtggaaaa gagcttcgag      720

acagacacca acctgaactt ccagaacctg agcgtgatcg gcttcagaat cctgctgctg      780

aaggtggccg gcttcaatct gctgatgacc ctgagactgt ggtccagctg a               831


<210>  39
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region; codon optimized

<400>  39
atggccagcc tgctgttctt ctgcggcgcc ttttatctgc tcggcaccgg ctctatggac       60

gccgacgtta cacagacccc tcggaacaga atcaccaaga ccggcaagcg gatcatgctg      120

gaatgcagcc agaccaaggg ccacgaccgg atgtactggt acagacagga ccctggcctg      180

ggcctgagac tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatcagc      240

gacggctaca gcgtgtcaag acaggctcag gccaagttca gcctgtctct ggaaagcgct      300

atccccaacc agacagccct gtacttctgc gccaccagcg actgggatag aagcggcgac      360

aaagagacac agtacttcgg ccctggcacc agactgctgg tgctggaaga tctgaacaag      420

gtgttccctc cagaggtggc cgtgttcgag ccttctaagg ccgagattgc ccacacacag      480

aaagccacac tcgtgtgcct ggctaccggc ttctttcctg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcacagcggc gtcagcacag atccccagcc tctgaaagaa      600

cagcccgctc tgaacgacag ccggtactgt ctgagcagca gactgagagt gtccgccaca      660

ttctggcaga accccagaaa ccacttcaga tgccaggtgc agttctacgg cctgagcgag      720

aacgatgagt ggacccagga tagagccaag cctgtgacac agatcgtgtc tgccgaagcc      780

tggggcagag ccgattgtgg aattaccagc gccagctacc atcagggcgt gctgtctgcc      840

acaatcctgt acgagatcct gctgggcaaa gccactctgt acgccgtgct ggtgtctgcc      900

ctggtgctga tggccatggt caagagaaag gacttttga                             939


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  40
accagcgatc ctagctacgg c                                                 21


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  41
cagggcagct acgaccagca gaat                                              24


<210>  42
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  42
tgtgccatga gcggcggcta caccggcggc ttcaagacaa tcttt                       45


<210>  43
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  43
agcggcgacc tgagc                                                        15


<210>  44
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  44
tactacaacg gcgaggaa                                                     18


<210>  45
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  45
tgtgccagct ctggcggaga tggcgacgag cagtttttt                              39


<210>  46
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region; codon optimized

<400>  46
atgagcctga gcagcctgct gaaggtcgtg acagcctctc tgtggctcgg acctggaatc       60

gcccagaaga tcacccagac acagcccggc atgttcgtgc aagagaaaga agccgtgaca      120

ctggactgca cctacgacac cagcgatcct agctacggcc tgttctggta caagcagcct      180

agcagcggcg agatgatctt cctgatctac cagggcagct acgaccagca gaatgccacc      240

gagggcagat acagcctgaa cttccagaag gcccggaagt ccgccaacct ggtcatttct      300

gctagccagc tgggcgacag cgccatgtac ttttgtgcca tgagcggcgg ctacaccggc      360

ggcttcaaga caatctttgg cgccggaacc agactgttcg tgaaggccaa tattcagaac      420

cccgatcctg ccgtgtacca gctgagagac agcaagagca gcgacaagag cgtgtgtctg      480

ttcaccgact tcgacagcca gaccaacgtg tcccagagca aggacagcga cgtgtacatc      540

accgacaaga ccgtgctgga catgcggagc atggacttca agagcaacag cgccgtggcc      600

tggtccaaca agagcgattt cgcctgcgcc aacgccttca acaatagcat tatccccgag      660

gacacattct tccccagctc cgatgtgccc tgcgacgtga agctggtgga aaagagcttc      720

gagacagaca ccaacctgaa cttccagaac ctgagcgtga tcggcttcag aatcctgctg      780

ctgaaggtgg ccggcttcaa tctgctgatg accctgagac tgtggtccag ctga            834


<210>  47
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region; codon optimized

<400>  47
atgggcttca gactgctgtg ctgcgtggcc ttttgtctgc ttggagccgg acctgtggat       60

agcggcgtta cccagacacc taagcacctg atcacagcca caggccagcg cgtgaccctg      120

agatgttctc ctagaagcgg cgacctgagc gtgtactggt atcagcagtc tctggaccag      180

ggcctgcagt tcctgatcca gtactacaac ggcgaggaaa gagccaaggg caacatcctg      240

gaacggttca gcgcccagca gttcccagat ctgcacagcg agctgaacct gagcagcctg      300

gaactgggag atagcgccct gtacttctgt gccagctctg gcggagatgg cgacgagcag      360

ttttttggcc ctggcaccag actgaccgtg ctggaggacc tgaagaacgt gttccctccg      420

gaggtggccg tgttcgagcc cagcaaagcc gagatcgcgc acacccagaa ggccaccctg      480

gtgtgcctgg ccaccggctt ctaccccgac cacgtggagc tgagctggtg ggtgaacggc      540

aaggaggtgc acagcggcgt gagcaccgac ccccagcccc tgaaggagca gcccgccctg      600

aacgacagcc gctactgcct gagcagccgc ctgcgcgtga gcgccacctt ctggcagaac      660

ccccgcaacc acttccgctg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg      720

acccaggacc gcgccaagcc cgtgacccag atcgtgagcg ccgaggcctg gggccgcgcc      780

gactgcggca ttaccagccg cagctaccat cagggcgtgc tgagcgccac catcctgtac      840

gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgagcgccct ggtgctgatg      900

gcgatggtga agcgcaagga cagccgcggc tga                                   933


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  48
gacagcgcca gcaactac                                                     18


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  49
atccggtcca acgtgggcga g                                                 21


<210>  50
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  50
tgcgctgcca gcagaggcac cggcttccag aaactggtgt tt                          42


<210>  51
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  51
ctgggccacg acacc                                                        15


<210>  52
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  52
tacaacaaca aagagctg                                                     18


<210>  53
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized

<400>  53
tgtgccagca gccagttctg ggatggcgct ggcgacgagc agtatttt                    48


<210>  54
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region; codon optimized

<400>  54
atgaccagca tccgggccgt gttcatcttc ctgtggctgc agctggacct ggtcaacggc       60

gagaatgtgg aacagcaccc cagcacactg agcgtgcaag agggcgattc tgccgtgatc      120

aagtgcacct acagcgacag cgccagcaac tacttcccct ggtacaagca agagctgggc      180

aaaagacccc agctgatcat cgacatccgg tccaacgtgg gcgagaagaa ggaccagaga      240

atcgccgtga cactgaacaa gaccgccaag cacttcagcc tgcacatcac cgagacacag      300

cctgaggata gcgccgtgta cttttgcgct gccagcagag gcaccggctt ccagaaactg      360

gtgtttggca ccggcaccag actgctggtg tccccaaata ttcagaaccc cgatcctgcc      420

gtgtaccagc tgagagacag caagagcagc gacaagagcg tgtgtctgtt caccgacttc      480

gacagccaga ccaacgtgtc ccagagcaag gacagcgacg tgtacatcac cgacaagacc      540

gtgctggaca tgcggagcat ggacttcaag agcaacagcg ccgtggcctg gtccaacaag      600

agcgatttcg cctgcgccaa cgccttcaac aatagcatta tccccgagga cacattcttc      660

cccagctccg atgtgccctg cgacgtgaag ctggtggaaa agagcttcga gacagacacc      720

aacctgaact tccagaacct gagcgtgatc ggcttcagaa tcctgctgct gaaggtggcc      780

ggcttcaatc tgctgatgac cctgagactg tggtccagct ga                         822


<210>  55
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with minimal murinized constant region; codon optimized

<400>  55
atgggctgca gactgctgtg ctgtgtggtg ttctgcctgc tgcaagccgg acctctggat       60

acagccgtgt ctcagacccc taagtacctg gtcacccaga tgggcaacga caagagcatc      120

aagtgcgagc agaacctggg ccacgacacc atgtactggt acaagcagga cagcaagaaa      180

ttcctgaaga tcatgttcag ctacaacaac aaagagctga tcatcaacga gacagtgccc      240

aacagattca gccctaagag ccccgataag gcccacctga acctgcacat caacagcctg      300

gaactgggcg acagcgccgt gtacttttgt gccagcagcc agttctggga tggcgctggc      360

gacgagcagt attttggccc tggcaccaga ctgaccgtga ccgaggacct gaacaaggtg      420

ttccctccgg aggtggccgt gttcgagccc agcaaagccg agatcgcgca cacccagaag      480

gccaccctgg tgtgcctggc caccggcttc ttccccgacc acgtggagct gagctggtgg      540

gtgaacggca aggaggtgca cagcggcgtg agcaccgacc cccagcccct gaaggagcag      600

cccgccctga acgacagccg ctactgcctg agcagccgcc tgcgcgtgag cgccaccttc      660

tggcagaacc cccgcaacca cttccgctgc caggtgcagt tctacggcct gagcgagaac      720

gacgagtgga cccaggaccg cgccaagccc gtgacccaga tcgtgagcgc cgaggcctgg      780

ggccgcgccg actgcggcat taccagcgcg agctaccatc agggcgtgct gagcgccacc      840

atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gagcgccctg      900

gtgctgatgg cgatggtgaa gcgcaaggac ttctga                                936


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Lys Leu Tyr Gly Leu Asp Trp Ala Glu Leu 
1               5                   10  


<210>  57
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinized

<400>  57

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  58
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinized

<400>  58

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Thr Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Lys Lys Asn Ser 
305             


<210>  59
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinized

<400>  59

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
        115                 120                 125             


Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  60
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinized

<400>  60

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


<210>  61
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinized

<400>  61

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  62
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinized

<400>  62

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Thr Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  63
acttcagacc agtcgtacgg t                                                 21


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  64
cagggatcgt acgacgagca gaac                                              24


<210>  65
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  65
tgcgcaatgt ccggcgatag cgcaggaaac atgctgactt tc                          42


<210>  66
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  66
aagggccacg accgc                                                        15


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  67
tccttcgacg tgaaggac                                                     18


<210>  68
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  68
tgtgccacct cggattggga ccgatccggc gacaaggaaa ctcagtactt c                51


<210>  69
<211>  831
<212>  DNA
<213>  human optimized

<400>  69
atgagcctct cttccctgct caaagtggtc actgcctccc tgtggctggg accgggaatc       60

gcccagaaga tcactcagac ccagcctgga atgttcgtgc aagagaaaga ggccgtgacc      120

ctggattgta cttatgacac ttcagaccag tcgtacggtt tgttctggta caagcagccg      180

tcctccggag aaatgatctt cctgatctac cagggatcgt acgacgagca gaacgctacc      240

gagggcagat attccctcaa cttccaaaag gcccggaaat ccgcgaacct cgtgatctcg      300

gcctcacaac ttggggactc cgctatgtat ttctgcgcaa tgtccggcga tagcgcagga      360

aacatgctga ctttcggcgg tggaactagg ctgatggtca agccccacat tcaaaaccct      420

gacccagcag tctaccagtt gcgggattcc aagtcttccg ataaatccgt gtgtctcttt      480

acagacttcg atagccagac caacgtgtcc cagagcaaag acagcgacgt gtacattact      540

gacaagactg tgctggacat gcggtccatg gacttcaaga gcaactccgc cgtcgcttgg      600

tccaacaagt ctgactttgc gtgcgcgaac gctttcaaca acagcattat cccggaggac      660

acctttttcc cttcccccga gtcaagctgc gatgtcaagc ttgtggaaaa gtcgttcgaa      720

accgacacca acctgaactt ccagaacctg tccgtcatcg ggttccgcat tctgctgctg      780

aaggtcgccg gcttcaatct cctgatgact ctccgcttgt ggtcctcata a               831


<210>  70
<211>  936
<212>  DNA
<213>  human optimized

<400>  70
atggcgtccc tgctgttctt ctgcggtgcc ttctaccttc tgggaaccgg ctcgatggac       60

gccgacgtga cccaaacccc tcgcaaccgc atcaccaaga ctggaaagcg gatcatgctg      120

gaatgctccc agaccaaggg ccacgaccgc atgtactggt acagacagga cccgggtctg      180

ggattgcgcc tgatctacta ctccttcgac gtgaaggaca tcaacaaggg ggagatctcc      240

gatggatact cagtctcgag acaagcccag gctaagtttt ccctgtccct cgaatccgcc      300

attcccaatc agaccgcgct gtacttctgt gccacctcgg attgggaccg atccggcgac      360

aaggaaactc agtacttcgg accaggaacc aggctcctgg tgctggagga tctgaacaag      420

gtgttcccgc cggaagtggc agtgttcgag ccatccgaag ccgagatctc gcatacgcag      480

aaggccaccc tcgtgtgcct ggccactggg tttttccctg accacgtgga gctctcgtgg      540

tgggtcaacg gaaaggaagt gcacagcggt gtctcaaccg acccgcaacc tctcaaggaa      600

cagcccgcgc tcaatgattc gcggtactgc ctgagcagcc ggctcagagt gtccgccact      660

ttctggcaaa acccgcggaa ccatttccgg tgccaagtgc aattctacgg gctgtcggaa      720

aacgacgaat ggacccagga cagggccaag cccgtgaccc agattgtgtc cgctgaagcc      780

tgggggagag ctgattgcgg tttcaccagc gtgtcgtatc agcagggcgt gctgtcagcc      840

accattctgt acgaaatcct cctggggaag gccacactgt acgccgtgct cgtgtccgcc      900

ctggtgctga tggccatggt caagcggaag gacttc                                936


<210>  71
<211>  21
<212>  DNA
<213>  human optimized

<400>  71
acctccgacc cgtcctacgg g                                                 21


<210>  72
<211>  24
<212>  DNA
<213>  human optimized

<400>  72
caaggctcct atgatcagca gaac                                              24


<210>  73
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  73
tgtgccatgt cgggcggata caccggggga ttcaagacca ttttc                       45


<210>  74
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  74
tctggcgacc tctcc                                                        15


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  75
tactacaacg gagaggag                                                     18


<210>  76
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  76
tgcgcaagca gcggtggtga cggggatgaa cagttcttt                              39


<210>  77
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  77
atgtccctta gctcactgct gaaagtggtc actgcgagcc tgtggctggg accaggcatt       60

gctcaaaaga tcacccagac tcagcctggg atgttcgtgc aagagaagga agccgtgacc      120

ctcgactgca cttacgacac ctccgacccg tcctacgggc tgttctggta caagcagccg      180

tcctccggag agatgatctt cctcatctac caaggctcct atgatcagca gaacgccacc      240

gaaggacgct acagcctgaa cttccagaag gctcggaagt cggcgaacct cgtgatcagc      300

gcatcccaac tgggggacag cgccatgtac ttctgtgcca tgtcgggcgg atacaccggg      360

ggattcaaga ccattttcgg ggccggcact agactgttcg tgaaggccaa catccagaat      420

cctgatccgg cggtgtatca gctgcgcgac tccaagtctt ccgataaatc cgtgtgtctc      480

tttacagact tcgactccca aaccaacgtg tcacagtcca aggacagcga tgtgtacatc      540

accgacaaaa ccgtgctgga catgcggtcc atggacttca agtcaaacag cgcagtcgcc      600

tggtccaaca agtccgactt cgcctgtgcg aacgccttca acaactccat cattccggaa      660

gatacctttt tcccttcacc tgagtcgagc tgtgatgtga agctcgtgga aaagtcgttt      720

gaaacggaca ccaacctgaa ctttcagaac ctgtccgtga ttggtttccg catcctgctg      780

ctgaaggtcg ccggcttcaa cttgctgatg acgctccggc tgtggtcctc gtaa            834


<210>  78
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  78
atgggattcc gccttctgtg ctgcgtggcc ttctgcttgc ttggagctgg tcccgtcgac       60

tcgggagtga cccagacgcc gaagcacttg attaccgcta ctgggcagcg cgtgactctg      120

cgatgctcac cacggtctgg cgacctctcc gtgtactggt atcagcagag cctggaccag      180

ggactgcagt tcctgatcca gtactacaac ggagaggagc gggctaaggg aaacatactg      240

gagcggttct cggcgcaaca attccccgat ctgcactccg aactgaacct gtcctccctg      300

gaattgggag actccgccct gtacttctgc gcaagcagcg gtggtgacgg ggatgaacag      360

ttctttggcc ctggaaccag actcaccgtg ctcgaggacc tcaagaacgt gttcccaccc      420

gaagtcgcgg tgttcgagcc ctccgaagcg gaaatcagcc atactcagaa agccactctc      480

gtgtgcctgg ccaccggatt ctacccggac cacgtcgagc tctcttggtg ggtgaacggg      540

aaagaggtcc acagcggcgt gagcactgat ccgcagccgc tgaaggaaca acccgccttg      600

aacgactcgc ggtactgtct gtcctcccgg ctgagagtgt cggccacctt ctggcaaaac      660

cccaggaacc actttaggtg ccaagtccag ttctacggcc tgagcgaaaa cgatgagtgg      720

acccaggaca gagccaagcc tgtgacccag attgtgtcag ccgaggcttg gggtagagca      780

gactgcggat tcacctccga gtcctaccaa caaggcgtcc tctcggcgac cattctgtac      840

gaaatcctgc ttgggaaggc cactctgtac gccgtgctgg tgtccgccct ggtgctgatg      900

gccatggtca agcggaagga ctcccggggg                                       930


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  79
gactcagcat caaactat                                                     18


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  80
atccgctcca acgtcggaga g                                                 21


<210>  81
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  81
tgtgcggcct cgaggggcac tgggtttcag aagctcgtgt tc                          42


<210>  82
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  82
ctcggacacg acacc                                                        15


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  83
tacaacaaca aggaactg                                                     18


<210>  84
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  84
tgcgcgtcca gccagttctg ggacggagcg ggcgacgaac agtacttc                    48


<210>  85
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  85
atgacgtcca ttagagccgt gttcattttc ctgtggctgc aactggacct cgtgaatgga       60

gaaaacgtcg agcagcaccc atccaccctg agcgtgcagg agggagactc cgcagtcatc      120

aagtgcactt actccgactc agcatcaaac tatttcccgt ggtataagca ggaactcgga      180

aagcggcctc agctcatcat tgacatccgc tccaacgtcg gagagaagaa ggaccagaga      240

attgccgtga cactcaacaa gaccgccaag catttctccc ttcacatcac cgaaacccag      300

cccgaggaca gcgccgtcta cttttgtgcg gcctcgaggg gcactgggtt tcagaagctc      360

gtgttcggca ctgggacccg gctgctggtg tcgccaaaca tccagaatcc agaccccgcg      420

gtgtaccagc tgagagactc gaagtcttcc gataaatccg tgtgtctctt tacagacttc      480

gatagccaga ctaacgtgtc ccagtccaag gactccgatg tgtacatcac cgacaagact      540

gtgctggata tgcggagcat ggactttaag tccaattcag cggtcgcgtg gagcaacaag      600

tccgacttcg cctgcgctaa cgctttcaac aactccatta tcccggagga taccttcttc      660

ccgtcaccgg aatcctcgtg cgacgtgaag ctggtcgaga agtccttcga aaccgatacc      720

aacctgaact tccaaaacct ctccgtgatc ggcttcagaa tcctgctgct gaaagtggct      780

ggcttcaatt tgctgatgac cctgcggctc tggagcagc                             819


<210>  86
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  86
atgggttgtc ggttgctgtg ttgcgtcgtg ttctgccttc ttcaagctgg tcctctcgat       60

actgccgtga gccaaacccc taagtacctt gtcacccaaa tgggcaacga caagtccatc      120

aaatgcgaac agaacctcgg acacgacacc atgtactggt acaaacagga ttccaagaag      180

ttcctgaaga ttatgttctc atacaacaac aaggaactga ttatcaacga aactgtgccg      240

aaccggttct caccgaagtc gcctgacaag gctcatctca acttgcatat caactcgctg      300

gagctcggcg actccgccgt gtacttctgc gcgtccagcc agttctggga cggagcgggc      360

gacgaacagt acttcggccc gggcactcgg ctgaccgtga ccgaagatct gaacaaagtg      420

ttcccccccg aagtggccgt gttcgaacct tccgaggccg agatcagcca cacccaaaag      480

gccactctgg tctgcctggc caccggtttc ttccccgatc acgtggaact gtcttggtgg      540

gtgaacggaa aagaagtgca ctcgggggtg tccacggacc cccagcctct gaaggaacag      600

ccggcactga atgactcacg ctactgtctg tcgtcacggc tgcgcgtgtc ggccaccttc      660

tggcaaaacc cgcgaaacca ctttcgctgc caagtgcagt tttacgggct ttccgagaac      720

gacgagtgga ctcaggacag agcgaagccc gtgacccaaa tcgtgtccgc cgaggcctgg      780

ggacgcgccg actgcggttt cacctccgtg agctaccaac agggcgtgct gtcagctacc      840

atcctttacg agatcctcct gggaaaggcc accctctacg ccgtcctggt gtccgcactg      900

gtgctgatgg ctatggtcaa gcggaaggat                                       930


<210>  87
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  88
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  89
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
        115                 120                 125             


Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  90
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  91
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  92
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp 
305                 310 


<210>  93
<211>  1833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  93
atggcgtccc tgctgttctt ctgcggtgcc ttctaccttc tgggaaccgg ctcgatggac       60

gccgacgtga cccaaacccc tcgcaaccgc atcaccaaga ctggaaagcg gatcatgctg      120

gaatgctccc agaccaaggg ccacgaccgc atgtactggt acagacagga cccgggtctg      180

ggattgcgcc tgatctacta ctccttcgac gtgaaggaca tcaacaaggg ggagatctcc      240

gatggatact cagtctcgag acaagcccag gctaagtttt ccctgtccct cgaatccgcc      300

attcccaatc agaccgcgct gtacttctgt gccacctcgg attgggaccg atccggcgac      360

aaggaaactc agtacttcgg accaggaacc aggctcctgg tgctggagga tctgaacaag      420

gtgttcccgc cggaagtggc agtgttcgag ccatccgaag ccgagatctc gcatacgcag      480

aaggccaccc tcgtgtgcct ggccactggg tttttccctg accacgtgga gctctcgtgg      540

tgggtcaacg gaaaggaagt gcacagcggt gtctcaaccg acccgcaacc tctcaaggaa      600

cagcccgcgc tcaatgattc gcggtactgc ctgagcagcc ggctcagagt gtccgccact      660

ttctggcaaa acccgcggaa ccatttccgg tgccaagtgc aattctacgg gctgtcggaa      720

aacgacgaat ggacccagga cagggccaag cccgtgaccc agattgtgtc cgctgaagcc      780

tgggggagag ctgattgcgg tttcaccagc gtgtcgtatc agcagggcgt gctgtcagcc      840

accattctgt acgaaatcct cctggggaag gccacactgt acgccgtgct cgtgtccgcc      900

ctggtgctga tggccatggt caagcggaag gacttcggca gcggagctac caacttctcc      960

ctgctgaagc aggccggcga tgtggaagaa aatcccggac ctatgagcct ctcttccctg     1020

ctcaaagtgg tcactgcctc cctgtggctg ggaccgggaa tcgcccagaa gatcactcag     1080

acccagcctg gaatgttcgt gcaagagaaa gaggccgtga ccctggattg tacttatgac     1140

acttcagacc agtcgtacgg tttgttctgg tacaagcagc cgtcctccgg agaaatgatc     1200

ttcctgatct accagggatc gtacgacgag cagaacgcta ccgagggcag atattccctc     1260

aacttccaaa aggcccggaa atccgcgaac ctcgtgatct cggcctcaca acttggggac     1320

tccgctatgt atttctgcgc aatgtccggc gatagcgcag gaaacatgct gactttcggc     1380

ggtggaacta ggctgatggt caagccccac attcaaaacc ctgacccagc agtctaccag     1440

ttgcgggatt ccaagtcttc cgataaatcc gtgtgtctct ttacagactt cgatagccag     1500

accaacgtgt cccagagcaa agacagcgac gtgtacatta ctgacaagac tgtgctggac     1560

atgcggtcca tggacttcaa gagcaactcc gccgtcgctt ggtccaacaa gtctgacttt     1620

gcgtgcgcga acgctttcaa caacagcatt atcccggagg acaccttttt cccttccccc     1680

gagtcaagct gcgatgtcaa gcttgtggaa aagtcgttcg aaaccgacac caacctgaac     1740

ttccagaacc tgtccgtcat cgggttccgc attctgctgc tgaaggtcgc cggcttcaat     1800

ctcctgatga ctctccgctt gtggtcctca taa                                  1833


<210>  94
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  94

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser 
                325                 330                 335     


Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu Gly Pro 
            340                 345                 350         


Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln 
        355                 360                 365             


Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln 
    370                 375                 380                 


Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile 
385                 390                 395                 400 


Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly 
                405                 410                 415     


Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val 
            420                 425                 430         


Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met 
        435                 440                 445             


Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg 
    450                 455                 460                 


Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
545                 550                 555                 560 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 


<210>  95
<211>  1842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  95
atgggattcc gccttctgtg ctgcgtggcc ttctgcttgc ttggagctgg tcccgtcgac       60

tcgggagtga cccagacgcc gaagcacttg attaccgcta ctgggcagcg cgtgactctg      120

cgatgctcac cacggtctgg cgacctctcc gtgtactggt atcagcagag cctggaccag      180

ggactgcagt tcctgatcca gtactacaac ggagaggagc gggctaaggg aaacatactg      240

gagcggttct cggcgcaaca attccccgat ctgcactccg aactgaacct gtcctccctg      300

gaattgggag actccgccct gtacttctgc gcaagcagcg gtggtgacgg ggatgaacag      360

ttctttggcc ctggaaccag actcaccgtg ctcgaggacc tcaagaacgt gttcccaccc      420

gaagtcgcgg tgttcgagcc ctccgaagcg gaaatcagcc atactcagaa agccactctc      480

gtgtgcctgg ccaccggatt ctacccggac cacgtcgagc tctcttggtg ggtgaacggg      540

aaagaggtcc acagcggcgt gagcactgat ccgcagccgc tgaaggaaca acccgccttg      600

aacgactcgc ggtactgtct gtcctcccgg ctgagagtgt cggccacctt ctggcaaaac      660

cccaggaacc actttaggtg ccaagtccag ttctacggcc tgagcgaaaa cgatgagtgg      720

acccaggaca gagccaagcc tgtgacccag attgtgtcag ccgaggcttg gggtagagca      780

gactgcggat tcacctccga gtcctaccaa caaggcgtcc tctcggcgac cattctgtac      840

gaaatcctgc ttgggaaggc cactctgtac gccgtgctgg tgtccgccct ggtgctgatg      900

gccatggtca agcggaagga ctcccggggg agagcaaaga ggggatcggg agccaccaat      960

tttagcctgc tgaagcaggc cggcgatgtg gaagaaaatc ctggccccat gtcccttagc     1020

tcactgctga aagtggtcac tgcgagcctg tggctgggac caggcattgc tcaaaagatc     1080

acccagactc agcctgggat gttcgtgcaa gagaaggaag ccgtgaccct cgactgcact     1140

tacgacacct ccgacccgtc ctacgggctg ttctggtaca agcagccgtc ctccggagag     1200

atgatcttcc tcatctacca aggctcctat gatcagcaga acgccaccga aggacgctac     1260

agcctgaact tccagaaggc tcggaagtcg gcgaacctcg tgatcagcgc atcccaactg     1320

ggggacagcg ccatgtactt ctgtgccatg tcgggcggat acaccggggg attcaagacc     1380

attttcgggg ccggcactag actgttcgtg aaggccaaca tccagaatcc tgatccggcg     1440

gtgtatcagc tgcgcgactc caagtcttcc gataaatccg tgtgtctctt tacagacttc     1500

gactcccaaa ccaacgtgtc acagtccaag gacagcgatg tgtacatcac cgacaaaacc     1560

gtgctggaca tgcggtccat ggacttcaag tcaaacagcg cagtcgcctg gtccaacaag     1620

tccgacttcg cctgtgcgaa cgccttcaac aactccatca ttccggaaga tacctttttc     1680

ccttcacctg agtcgagctg tgatgtgaag ctcgtggaaa agtcgtttga aacggacacc     1740

aacctgaact ttcagaacct gtccgtgatt ggtttccgca tcctgctgct gaaggtcgcc     1800

ggcttcaact tgctgatgac gctccggctg tggtcctcgt aa                        1842


<210>  96
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  96

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                325                 330                 335     


Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
            340                 345                 350         


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
        355                 360                 365             


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
    370                 375                 380                 


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
385                 390                 395                 400 


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
                405                 410                 415     


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
            420                 425                 430         


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
        435                 440                 445             


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
    450                 455                 460                 


Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Asp Pro Ala 
465                 470                 475                 480 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
                485                 490                 495     


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
            500                 505                 510         


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
        515                 520                 525             


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
    530                 535                 540                 


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
545                 550                 555                 560 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
                565                 570                 575     


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
            580                 585                 590         


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
        595                 600                 605             


Arg Leu Trp Ser Ser 
    610             


<210>  97
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  97
atgggttgtc ggttgctgtg ttgcgtcgtg ttctgccttc ttcaagctgg tcctctcgat       60

actgccgtga gccaaacccc taagtacctt gtcacccaaa tgggcaacga caagtccatc      120

aaatgcgaac agaacctcgg acacgacacc atgtactggt acaaacagga ttccaagaag      180

ttcctgaaga ttatgttctc atacaacaac aaggaactga ttatcaacga aactgtgccg      240

aaccggttct caccgaagtc gcctgacaag gctcatctca acttgcatat caactcgctg      300

gagctcggcg actccgccgt gtacttctgc gcgtccagcc agttctggga cggagcgggc      360

gacgaacagt acttcggccc gggcactcgg ctgaccgtga ccgaagatct gaacaaagtg      420

ttcccccccg aagtggccgt gttcgaacct tccgaggccg agatcagcca cacccaaaag      480

gccactctgg tctgcctggc caccggtttc ttccccgatc acgtggaact gtcttggtgg      540

gtgaacggaa aagaagtgca ctcgggggtg tccacggacc cccagcctct gaaggaacag      600

ccggcactga atgactcacg ctactgtctg tcgtcacggc tgcgcgtgtc ggccaccttc      660

tggcaaaacc cgcgaaacca ctttcgctgc caagtgcagt tttacgggct ttccgagaac      720

gacgagtgga ctcaggacag agcgaagccc gtgacccaaa tcgtgtccgc cgaggcctgg      780

ggacgcgccg actgcggttt cacctccgtg agctaccaac agggcgtgct gtcagctacc      840

atcctttacg agatcctcct gggaaaggcc accctctacg ccgtcctggt gtccgcactg      900

gtgctgatgg ctatggtcaa gcggaaggat tttagggcca aacgcgggtc cggagcgacc      960

aacttctcgc tgttgaagca ggccggcgat gtggaagaga accctggacc gatgacgtcc     1020

attagagccg tgttcatttt cctgtggctg caactggacc tcgtgaatgg agaaaacgtc     1080

gagcagcacc catccaccct gagcgtgcag gagggagact ccgcagtcat caagtgcact     1140

tactccgact cagcatcaaa ctatttcccg tggtataagc aggaactcgg aaagcggcct     1200

cagctcatca ttgacatccg ctccaacgtc ggagagaaga aggaccagag aattgccgtg     1260

acactcaaca agaccgccaa gcatttctcc cttcacatca ccgaaaccca gcccgaggac     1320

agcgccgtct acttttgtgc ggcctcgagg ggcactgggt ttcagaagct cgtgttcggc     1380

actgggaccc ggctgctggt gtcgccaaac atccagaatc cagaccccgc ggtgtaccag     1440

ctgagagact cgaagtcttc cgataaatcc gtgtgtctct ttacagactt cgatagccag     1500

actaacgtgt cccagtccaa ggactccgat gtgtacatca ccgacaagac tgtgctggat     1560

atgcggagca tggactttaa gtccaattca gcggtcgcgt ggagcaacaa gtccgacttc     1620

gcctgcgcta acgctttcaa caactccatt atcccggagg ataccttctt cccgtcaccg     1680

gaatcctcgt gcgacgtgaa gctggtcgag aagtccttcg aaaccgatac caacctgaac     1740

ttccaaaacc tctccgtgat cggcttcaga atcctgctgc tgaaagtggc tggcttcaat     1800

ttgctgatga ccctgcggct ctggagcagc                                      1830


<210>  98
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human optimized

<400>  98

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe Arg Ala Lys Arg Gly Ser Gly Ala Thr 
305                 310                 315                 320 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                325                 330                 335     


Pro Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu 
            340                 345                 350         


Asp Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser 
        355                 360                 365             


Val Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser 
    370                 375                 380                 


Ala Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro 
385                 390                 395                 400 


Gln Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln 
                405                 410                 415     


Arg Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His 
            420                 425                 430         


Ile Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala 
        435                 440                 445             


Ser Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg 
    450                 455                 460                 


Leu Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
545                 550                 555                 560 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 


<210>  99
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-7 a complete 

<400>  99
atgagcctct cttccctgct caaagtggtc actgcctccc tgtggctggg accgggaatc       60

gcccagaaga tcactcagac ccagcctgga atgttcgtgc aagagaaaga ggccgtgacc      120

ctggattgta cttatgacac ttcagaccag tcgtacggtt tgttctggta caagcagccg      180

tcctccggag aaatgatctt cctgatctac cagggatcgt acgacgagca gaacgctacc      240

gagggcagat attccctcaa cttccaaaag gcccggaaat ccgcgaacct cgtgatctcg      300

gcctcacaac ttggggactc cgctatgtat ttctgcgcaa tgtccggcga tagcgcagga      360

aacatgctga ctttcggcgg tggaactagg ctgatggtca agccccacat tcaaaaccct      420

gacccagcag tctaccagtt gcgggattcc aagtcttccg ataaatccgt gtgtctcttt      480

acagacttcg atagccagac caacgtgtcc cagagcaaag acagcgacgt gtacattact      540

gacaagactg tgctggacat gcggtccatg gacttcaaga gcaactccgc cgtcgcttgg      600

tccaacaagt ctgactttgc gtgcgcgaac gctttcaaca acagcattat cccggaggac      660

acctttttcc cttccagcga cgtcccctgc gatgtcaagc ttgtggaaaa gtcgttcgaa      720

accgacacca acctgaactt ccagaacctg ctagtgattg tgctccgcat tctgctgctg      780

aaggtcgccg gcttcaatct cctgatgact ctccgcttgt ggtcctca                   828


<210>  100
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-7 b complete 

<400>  100
atggcgtccc tgctgttctt ctgcggtgcc ttctaccttc tgggaaccgg ctcgatggac       60

gccgacgtga cccaaacccc tcgcaaccgc atcaccaaga ctggaaagcg gatcatgctg      120

gaatgctccc agaccaaggg ccacgaccgc atgtactggt acagacagga cccgggtctg      180

ggattgcgcc tgatctacta ctccttcgac gtgaaggaca tcaacaaggg ggagatctcc      240

gatggatact cagtctcgag acaagcccag gctaagtttt ccctgtccct cgaatccgcc      300

attcccaatc agaccgcgct gtacttctgt gccacctcgg attgggaccg atccggcgac      360

aaggaaactc agtacttcgg accaggaacc aggctcctgg tgctggagga tctgaacaag      420

gtgttcccgc cggaagtggc agtgttcgag ccatccaagg cggagatcgc ccatacgcag      480

aaggccaccc tcgtgtgcct ggccactggg tttttccctg accacgtgga gctctcgtgg      540

tgggtcaacg gaaaggaagt gcacagcggt gtctcaaccg acccgcaacc tctcaaggaa      600

cagcccgcgc tcaatgattc gcggtactgc ctgagcagcc ggctcagagt gtccgccact      660

ttctggcaaa acccgcggaa ccatttccgg tgccaagtgc aattctacgg gctgtcggaa      720

aacgacgaat ggacccagga cagggccaag cccgtgaccc agattgtgtc cgctgaagcc      780

tgggggagag ctgattgcgg tatcaccagc gccagctacc accagggcgt gctgtcagcc      840

accattctgt acgaaatcct cctggggaag gccacactgt acgccgtgct cgtgtccgcc      900

ctggtgctga tggccatggt caagcggaag gacttc                                936


<210>  101
<211>  1833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-7 polycistronic construct 

<400>  101
atggcgtccc tgctgttctt ctgcggtgcc ttctaccttc tgggaaccgg ctcgatggac       60

gccgacgtga cccaaacccc tcgcaaccgc atcaccaaga ctggaaagcg gatcatgctg      120

gaatgctccc agaccaaggg ccacgaccgc atgtactggt acagacagga cccgggtctg      180

ggattgcgcc tgatctacta ctccttcgac gtgaaggaca tcaacaaggg ggagatctcc      240

gatggatact cagtctcgag acaagcccag gctaagtttt ccctgtccct cgaatccgcc      300

attcccaatc agaccgcgct gtacttctgt gccacctcgg attgggaccg atccggcgac      360

aaggaaactc agtacttcgg accaggaacc aggctcctgg tgctggagga tctgaacaag      420

gtgttcccgc cggaagtggc agtgttcgag ccatccaagg cggagatcgc ccatacgcag      480

aaggccaccc tcgtgtgcct ggccactggg tttttccctg accacgtgga gctctcgtgg      540

tgggtcaacg gaaaggaagt gcacagcggt gtctcaaccg acccgcaacc tctcaaggaa      600

cagcccgcgc tcaatgattc gcggtactgc ctgagcagcc ggctcagagt gtccgccact      660

ttctggcaaa acccgcggaa ccatttccgg tgccaagtgc aattctacgg gctgtcggaa      720

aacgacgaat ggacccagga cagggccaag cccgtgaccc agattgtgtc cgctgaagcc      780

tgggggagag ctgattgcgg tatcaccagc gccagctacc accagggcgt gctgtcagcc      840

accattctgt acgaaatcct cctggggaag gccacactgt acgccgtgct cgtgtccgcc      900

ctggtgctga tggccatggt caagcggaag gacttcggca gcggagctac caacttctcc      960

ctgctgaagc aggccggcga tgtggaagaa aatcccggac ctatgagcct ctcttccctg     1020

ctcaaagtgg tcactgcctc cctgtggctg ggaccgggaa tcgcccagaa gatcactcag     1080

acccagcctg gaatgttcgt gcaagagaaa gaggccgtga ccctggattg tacttatgac     1140

acttcagacc agtcgtacgg tttgttctgg tacaagcagc cgtcctccgg agaaatgatc     1200

ttcctgatct accagggatc gtacgacgag cagaacgcta ccgagggcag atattccctc     1260

aacttccaaa aggcccggaa atccgcgaac ctcgtgatct cggcctcaca acttggggac     1320

tccgctatgt atttctgcgc aatgtccggc gatagcgcag gaaacatgct gactttcggc     1380

ggtggaacta ggctgatggt caagccccac attcaaaacc ctgacccagc agtctaccag     1440

ttgcgggatt ccaagtcttc cgataaatcc gtgtgtctct ttacagactt cgatagccag     1500

accaacgtgt cccagagcaa agacagcgac gtgtacatta ctgacaagac tgtgctggac     1560

atgcggtcca tggacttcaa gagcaactcc gccgtcgctt ggtccaacaa gtctgacttt     1620

gcgtgcgcga acgctttcaa caacagcatt atcccggagg acaccttttt cccttccagc     1680

gacgtcccct gcgatgtcaa gcttgtggaa aagtcgttcg aaaccgacac caacctgaac     1740

ttccagaacc tgctagtgat tgtgctccgc attctgctgc tgaaggtcgc cggcttcaat     1800

ctcctgatga ctctccgctt gtggtcctca taa                                  1833


<210>  102
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-7 a complete 

<400>  102

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  103
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-7 b complete 

<400>  103

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  104
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-7 polyprotein

<400>  104

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Asp Trp Asp Arg Ser Gly Asp Lys Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser 
                325                 330                 335     


Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu Gly Pro 
            340                 345                 350         


Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln 
        355                 360                 365             


Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln 
    370                 375                 380                 


Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile 
385                 390                 395                 400 


Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly 
                405                 410                 415     


Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val 
            420                 425                 430         


Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met 
        435                 440                 445             


Ser Gly Asp Ser Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg 
    450                 455                 460                 


Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Ser 
545                 550                 555                 560 


Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 


<210>  105
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-8 a complete 

<400>  105
atgtccctta gctcactgct gaaagtggtc actgcgagcc tgtggctggg accaggcatt       60

gctcaaaaga tcacccagac tcagcctggg atgttcgtgc aagagaagga agccgtgacc      120

ctcgactgca cttacgacac ctccgacccg tcctacgggc tgttctggta caagcagccg      180

tcctccggag agatgatctt cctcatctac caaggctcct atgatcagca gaacgccacc      240

gaaggacgct acagcctgaa cttccagaag gctcggaagt cggcgaacct cgtgatcagc      300

gcatcccaac tgggggacag cgccatgtac ttctgtgcca tgtcgggcgg atacaccggg      360

ggattcaaga ccattttcgg ggccggcact agactgttcg tgaaggccaa catccagaat      420

cctgatccgg cggtgtatca gctgcgcgac tccaagtctt ccgataaatc cgtgtgtctc      480

tttacagact tcgactccca aaccaacgtg tcacagtcca aggacagcga tgtgtacatc      540

accgacaaaa ccgtgctgga catgcggtcc atggacttca agtcaaacag cgcagtcgcc      600

tggtccaaca agtccgactt cgcctgtgcg aacgccttca acaactccat cattccggaa      660

gatacctttt tcccttcaag cgacgtcccc tgtgatgtga agctcgtgga aaagtcgttt      720

gaaacggaca ccaacctgaa ctttcagaac ctgctagtga ttgtgctccg catcctgctg      780

ctgaaggtcg ccggcttcaa cttgctgatg acgctccggc tgtggtcctc g               831


<210>  106
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-8 b complete

<400>  106
atgggattcc gccttctgtg ctgcgtggcc ttctgcttgc ttggagctgg tcccgtcgac       60

tcgggagtga cccagacgcc gaagcacttg attaccgcta ctgggcagcg cgtgactctg      120

cgatgctcac cacggtctgg cgacctctcc gtgtactggt atcagcagag cctggaccag      180

ggactgcagt tcctgatcca gtactacaac ggagaggagc gggctaaggg aaacatactg      240

gagcggttct cggcgcaaca attccccgat ctgcactccg aactgaacct gtcctccctg      300

gaattgggag actccgccct gtacttctgc gcaagcagcg gtggtgacgg ggatgaacag      360

ttctttggcc ctggaaccag actcaccgtg ctcgaggacc tcaagaacgt gttcccaccc      420

gaagtcgcgg tgttcgagcc ctccaaggcg gagatcgccc atactcagaa agccactctc      480

gtgtgcctgg ccaccggatt ctacccggac cacgtcgagc tctcttggtg ggtgaacggg      540

aaagaggtcc acagcggcgt gagcactgat ccgcagccgc tgaaggaaca acccgccttg      600

aacgactcgc ggtactgtct gtcctcccgg ctgagagtgt cggccacctt ctggcaaaac      660

cccaggaacc actttaggtg ccaagtccag ttctacggcc tgagcgaaaa cgatgagtgg      720

acccaggaca gagccaagcc tgtgacccag attgtgtcag ccgaggcttg gggtagagca      780

gactgcggaa tcaccagcgc cagctaccac caaggcgtcc tctcggcgac cattctgtac      840

gaaatcctgc ttgggaaggc cactctgtac gccgtgctgg tgtccgccct ggtgctgatg      900

gccatggtca agcggaagga ctcccggggg                                       930


<210>  107
<211>  1842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-8 polycistronic construct 

<400>  107
atgggattcc gccttctgtg ctgcgtggcc ttctgcttgc ttggagctgg tcccgtcgac       60

tcgggagtga cccagacgcc gaagcacttg attaccgcta ctgggcagcg cgtgactctg      120

cgatgctcac cacggtctgg cgacctctcc gtgtactggt atcagcagag cctggaccag      180

ggactgcagt tcctgatcca gtactacaac ggagaggagc gggctaaggg aaacatactg      240

gagcggttct cggcgcaaca attccccgat ctgcactccg aactgaacct gtcctccctg      300

gaattgggag actccgccct gtacttctgc gcaagcagcg gtggtgacgg ggatgaacag      360

ttctttggcc ctggaaccag actcaccgtg ctcgaggacc tcaagaacgt gttcccaccc      420

gaagtcgcgg tgttcgagcc ctccaaggcg gagatcgccc atactcagaa agccactctc      480

gtgtgcctgg ccaccggatt ctacccggac cacgtcgagc tctcttggtg ggtgaacggg      540

aaagaggtcc acagcggcgt gagcactgat ccgcagccgc tgaaggaaca acccgccttg      600

aacgactcgc ggtactgtct gtcctcccgg ctgagagtgt cggccacctt ctggcaaaac      660

cccaggaacc actttaggtg ccaagtccag ttctacggcc tgagcgaaaa cgatgagtgg      720

acccaggaca gagccaagcc tgtgacccag attgtgtcag ccgaggcttg gggtagagca      780

gactgcggaa tcaccagcgc cagctaccac caaggcgtcc tctcggcgac cattctgtac      840

gaaatcctgc ttgggaaggc cactctgtac gccgtgctgg tgtccgccct ggtgctgatg      900

gccatggtca agcggaagga ctcccggggg agagcaaaga ggggatcggg agccaccaat      960

tttagcctgc tgaagcaggc cggcgatgtg gaagaaaatc ctggccccat gtcccttagc     1020

tcactgctga aagtggtcac tgcgagcctg tggctgggac caggcattgc tcaaaagatc     1080

acccagactc agcctgggat gttcgtgcaa gagaaggaag ccgtgaccct cgactgcact     1140

tacgacacct ccgacccgtc ctacgggctg ttctggtaca agcagccgtc ctccggagag     1200

atgatcttcc tcatctacca aggctcctat gatcagcaga acgccaccga aggacgctac     1260

agcctgaact tccagaaggc tcggaagtcg gcgaacctcg tgatcagcgc atcccaactg     1320

ggggacagcg ccatgtactt ctgtgccatg tcgggcggat acaccggggg attcaagacc     1380

attttcgggg ccggcactag actgttcgtg aaggccaaca tccagaatcc tgatccggcg     1440

gtgtatcagc tgcgcgactc caagtcttcc gataaatccg tgtgtctctt tacagacttc     1500

gactcccaaa ccaacgtgtc acagtccaag gacagcgatg tgtacatcac cgacaaaacc     1560

gtgctggaca tgcggtccat ggacttcaag tcaaacagcg cagtcgcctg gtccaacaag     1620

tccgacttcg cctgtgcgaa cgccttcaac aactccatca ttccggaaga tacctttttc     1680

ccttcaagcg acgtcccctg tgatgtgaag ctcgtggaaa agtcgtttga aacggacacc     1740

aacctgaact ttcagaacct gctagtgatt gtgctccgca tcctgctgct gaaggtcgcc     1800

ggcttcaact tgctgatgac gctccggctg tggtcctcgt aa                        1842


<210>  108
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-8 a complete 

<400>  108

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
        115                 120                 125             


Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  109
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-8 b complete 

<400>  109

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  110
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-8 polyprotein

<400>  110

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asp Gly Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                325                 330                 335     


Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
            340                 345                 350         


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
        355                 360                 365             


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
    370                 375                 380                 


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
385                 390                 395                 400 


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
                405                 410                 415     


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
            420                 425                 430         


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
        435                 440                 445             


Ala Met Ser Gly Gly Tyr Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala 
    450                 455                 460                 


Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Asp Pro Ala 
465                 470                 475                 480 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
                485                 490                 495     


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
            500                 505                 510         


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
        515                 520                 525             


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
    530                 535                 540                 


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
545                 550                 555                 560 


Pro Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
                565                 570                 575     


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu 
            580                 585                 590         


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
        595                 600                 605             


Arg Leu Trp Ser Ser 
    610             


<210>  111
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-9 a complete 

<400>  111
atgacgtcca ttagagccgt gttcattttc ctgtggctgc aactggacct cgtgaatgga       60

gaaaacgtcg agcagcaccc atccaccctg agcgtgcagg agggagactc cgcagtcatc      120

aagtgcactt actccgactc agcatcaaac tatttcccgt ggtataagca ggaactcgga      180

aagcggcctc agctcatcat tgacatccgc tccaacgtcg gagagaagaa ggaccagaga      240

attgccgtga cactcaacaa gaccgccaag catttctccc ttcacatcac cgaaacccag      300

cccgaggaca gcgccgtcta cttttgtgcg gcctcgaggg gcactgggtt tcagaagctc      360

gtgttcggca ctgggacccg gctgctggtg tcgccaaaca tccagaatcc agaccccgcg      420

gtgtaccagc tgagagactc gaagtcttcc gataaatccg tgtgtctctt tacagacttc      480

gatagccaga ctaacgtgtc ccagtccaag gactccgatg tgtacatcac cgacaagact      540

gtgctggata tgcggagcat ggactttaag tccaattcag cggtcgcgtg gagcaacaag      600

tccgacttcg cctgcgctaa cgctttcaac aactccatta tcccggagga taccttcttc      660

ccgtcaagcg acgtcccctg cgacgtgaag ctggtcgaga agtccttcga aaccgatacc      720

aacctgaact tccaaaacct cctagtgatt gtgctcagaa tcctgctgct gaaagtggct      780

ggcttcaatt tgctgatgac cctgcggctc tggagcagc                             819


<210>  112
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-9 b complete 

<400>  112
atgggttgtc ggttgctgtg ttgcgtcgtg ttctgccttc ttcaagctgg tcctctcgat       60

actgccgtga gccaaacccc taagtacctt gtcacccaaa tgggcaacga caagtccatc      120

aaatgcgaac agaacctcgg acacgacacc atgtactggt acaaacagga ttccaagaag      180

ttcctgaaga ttatgttctc atacaacaac aaggaactga ttatcaacga aactgtgccg      240

aaccggttct caccgaagtc gcctgacaag gctcatctca acttgcatat caactcgctg      300

gagctcggcg actccgccgt gtacttctgc gcgtccagcc agttctggga cggagcgggc      360

gacgaacagt acttcggccc gggcactcgg ctgaccgtga ccgaagatct gaacaaagtg      420

ttcccccccg aagtggccgt gttcgaacct tccaaggcgg agatcgccca cacccaaaag      480

gccactctgg tctgcctggc caccggtttc ttccccgatc acgtggaact gtcttggtgg      540

gtgaacggaa aagaagtgca ctcgggggtg tccacggacc cccagcctct gaaggaacag      600

ccggcactga atgactcacg ctactgtctg tcgtcacggc tgcgcgtgtc ggccaccttc      660

tggcaaaacc cgcgaaacca ctttcgctgc caagtgcagt tttacgggct ttccgagaac      720

gacgagtgga ctcaggacag agcgaagccc gtgacccaaa tcgtgtccgc cgaggcctgg      780

ggacgcgccg actgcggtat caccagcgcc agctaccacc agggcgtgct gtcagctacc      840

atcctttacg agatcctcct gggaaaggcc accctctacg ccgtcctggt gtccgcactg      900

gtgctgatgg ctatggtcaa gcggaaggat                                       930


<210>  113
<211>  1833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR-9 polycistronic construct 

<400>  113
atgggttgtc ggttgctgtg ttgcgtcgtg ttctgccttc ttcaagctgg tcctctcgat       60

actgccgtga gccaaacccc taagtacctt gtcacccaaa tgggcaacga caagtccatc      120

aaatgcgaac agaacctcgg acacgacacc atgtactggt acaaacagga ttccaagaag      180

ttcctgaaga ttatgttctc atacaacaac aaggaactga ttatcaacga aactgtgccg      240

aaccggttct caccgaagtc gcctgacaag gctcatctca acttgcatat caactcgctg      300

gagctcggcg actccgccgt gtacttctgc gcgtccagcc agttctggga cggagcgggc      360

gacgaacagt acttcggccc gggcactcgg ctgaccgtga ccgaagatct gaacaaagtg      420

ttcccccccg aagtggccgt gttcgaacct tccaaggcgg agatcgccca cacccaaaag      480

gccactctgg tctgcctggc caccggtttc ttccccgatc acgtggaact gtcttggtgg      540

gtgaacggaa aagaagtgca ctcgggggtg tccacggacc cccagcctct gaaggaacag      600

ccggcactga atgactcacg ctactgtctg tcgtcacggc tgcgcgtgtc ggccaccttc      660

tggcaaaacc cgcgaaacca ctttcgctgc caagtgcagt tttacgggct ttccgagaac      720

gacgagtgga ctcaggacag agcgaagccc gtgacccaaa tcgtgtccgc cgaggcctgg      780

ggacgcgccg actgcggtat caccagcgcc agctaccacc agggcgtgct gtcagctacc      840

atcctttacg agatcctcct gggaaaggcc accctctacg ccgtcctggt gtccgcactg      900

gtgctgatgg ctatggtcaa gcggaaggat tttagggcca aacgcgggtc cggagcgacc      960

aacttctcgc tgttgaagca ggccggcgat gtggaagaga accctggacc gatgacgtcc     1020

attagagccg tgttcatttt cctgtggctg caactggacc tcgtgaatgg agaaaacgtc     1080

gagcagcacc catccaccct gagcgtgcag gagggagact ccgcagtcat caagtgcact     1140

tactccgact cagcatcaaa ctatttcccg tggtataagc aggaactcgg aaagcggcct     1200

cagctcatca ttgacatccg ctccaacgtc ggagagaaga aggaccagag aattgccgtg     1260

acactcaaca agaccgccaa gcatttctcc cttcacatca ccgaaaccca gcccgaggac     1320

agcgccgtct acttttgtgc ggcctcgagg ggcactgggt ttcagaagct cgtgttcggc     1380

actgggaccc ggctgctggt gtcgccaaac atccagaatc cagaccccgc ggtgtaccag     1440

ctgagagact cgaagtcttc cgataaatcc gtgtgtctct ttacagactt cgatagccag     1500

actaacgtgt cccagtccaa ggactccgat gtgtacatca ccgacaagac tgtgctggat     1560

atgcggagca tggactttaa gtccaattca gcggtcgcgt ggagcaacaa gtccgacttc     1620

gcctgcgcta acgctttcaa caactccatt atcccggagg ataccttctt cccgtcaagc     1680

gacgtcccct gcgacgtgaa gctggtcgag aagtccttcg aaaccgatac caacctgaac     1740

ttccaaaacc tcctagtgat tgtgctcaga atcctgctgc tgaaagtggc tggcttcaat     1800

ttgctgatga ccctgcggct ctggagcagc taa                                  1833


<210>  114
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-9 a complete 

<400>  114

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  115
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-9 b complete 

<400>  115

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
            260                 265                 270         


His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp 
305                 310 


<210>  116
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR-9 polyprotein

<400>  116

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gln Phe Trp Asp Gly Ala Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
            260                 265                 270         


His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe Arg Ala Lys Arg Gly Ser Gly Ala Thr 
305                 310                 315                 320 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                325                 330                 335     


Pro Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu 
            340                 345                 350         


Asp Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser 
        355                 360                 365             


Val Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser 
    370                 375                 380                 


Ala Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro 
385                 390                 395                 400 


Gln Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln 
                405                 410                 415     


Arg Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His 
            420                 425                 430         


Ile Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala 
        435                 440                 445             


Ser Arg Gly Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg 
    450                 455                 460                 


Leu Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Ser 
545                 550                 555                 560 


Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 


